Nobukuni Yoshitaka 信國好俊

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NOBUKUNI Yoshitaka 信國好俊

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Researcher Number	80295641
Other IDs
Affiliation (Current)	2025: 久留米大学, 付置研究所, 研究員
Affiliation (based on the past Project Information) *help	2009 – 2015: Hiroshima University, 原爆放射線医科学研究所, 准教授 2004: Kanazawa University, Graduate School of Medical Science, Lecturer, 医学系研究科, 講師 2003 – 2004: 広島大学, 原爆放射線医科学研究所, 助教授 2002: Kanazawa University, Graduate School of Medical Science, Assistant Professor, 医学系研究科, 講師 1998 – 2000: 京都府立医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Hygiene / General medical chemistry / Pathological medical chemistry / Biological Sciences Except Principal Investigator Hygiene / Environmental pharmacy
Keywords	Principal Investigator ジーントラップ / UBC9 / UBE2I / 遺伝子機能 / 遺伝子 / 挿入変異 / ribozyme / gene structure / gene function / UBE21 … More / リボザイム / 遺伝子構造 / 活性酸素 / P450 / 責任遺伝子 / ヒ素 / 責任遺伝子探索 / トキシコゲノミクス / ゲノム機能 / 抗がん剤耐性 / 薬毒物耐性 / 薬毒物感受性 / 三酸化ヒ素 / 脂質輸送 / 脂質代謝 / 分子疫学 / 候補遺伝子解析 / ジーントラップ挿入変異 / 細胞機能遺伝学 / ゲノム機能学 / コレステロール代謝・輸送 / ゲノム / レステロール / 高脂血症 / 脂質 / 予防医学 / 衛生 / CHO細胞 / 挿入変異細胞ライブラリー / ジフタマイド / ジフテリア毒素 / 蛋白合成制御 / 代謝輸送 / コレステロール / ライブラリー / 変異細胞 … More Except Principal Investigator indomethacin / CRH / myeloperoxidase / myoglobin / homoglobin / myocardial infarction / immunohistochemistry / heart / nitrotyrosine / peoxidase / 好酸球 / HPLC / 免疫組織 / ニトロ化 / ミクロペルオキシダーゼ / チトクロームC / 虚血 / NO / 亜硝酸 / 心筋細胞 / ミエロペルオキシダーゼ / ミオグロビン / ヘモグロビン / 心筋梗塞 / 免疫組織化学 / 心臓 / ニトロチロシン / ペルオキシダーゼ / fetus / SAR / heat / pregnancy / uteroplacental blood flow / microwaves / 妊娠 / オピオイド系 / 視床下部 / 子宮胎盤循環 / 胎児 / マイクロ波 / 内皮細胞 / 毒性 / 有機化学物質 / CHO細胞 / 血管内皮細胞 / ジーントラップ法 / 有機金属化合物 / ハイブリッド分子 / アンチモン / ビスマス / 細胞毒性 Less

Functional genetic screening of the genes involved in the arsenite sensitivityPrincipal Investigator
- Principal Investigator
  
  Nobukuni Yoshitaka
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  Hiroshima University
Modification of organometallic compound cytotoxicity by incorporated metal atoms and molecular mechanisms underlying the toxicity
- Principal Investigator
  
  YAMAMOTO Chika
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Toho University
  Hokuriku University
Clarification of the genes involved in the hyperlipidemia and the application to the preventive medicinePrincipal Investigator
- Principal Investigator
  
  NOBUKUNI Yoshitaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Hiroshima University
ジーントラップ法を用いた蛋白合成制御とその異常による発がん機構の解明Principal Investigator
- Principal Investigator
  
  信國好俊
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hiroshima University
Generation mechanisms of nitrogen dioxide-like species from cardiovascular system.
- Principal Investigator
  
  OGINO Keiki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Kanazawa University
Study on preventing systems of fetus for uteroplacental circulatory disturbances and uteroplacental dysfunctions produced by microwaves
- Principal Investigator
  
  NAKAMURA Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Kanazawa University
ジーントラップ挿入変異ライブラリーを用いた高脂血症発症に関与する遺伝子群の同定Principal Investigator
- Principal Investigator
  
  信国好俊
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Prefectural University of Medicine
Functional and structural analyses of the ubiquitin conjugating enzyme UBE2I genePrincipal Investigator
- Principal Investigator
  
  NOBUKUNI Yoshitaka
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto prefectural university of medicine

All 2016 2015 2014 2013 2012 2011 2010 2009 2005 2004 Other

All Journal Article Presentation

[Journal Article] Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 22005
- Author(s)
  Nobukuni Y., Kohno K., Miyagawa K.
- Journal Title
  
  J Biol Chem. 280
  
  Pages: 10572-10577
- NAID
  130007000772
- Data Source
  KAKENHI-PROJECT-15659074
[Journal Article] Induction of myeloperoxidase and nitrotyrosine formation in a human eosinophilic leukemia cell line, Eol-1.2004
- Author(s)
  Kodama N, Kambaayashi Y, Kubo M, Yoneyama S, Nobukuni Y, Nakamura H, Ogino K
- Journal Title
  
  Biochem Funct 22
  
  Pages: 105-112
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370120
[Journal Article] Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with Japanese cedar pollinosis.2004
- Author(s)
  Nakamura H, Higashikawa F, Miyagawa K, Nobukuni Y, Endo T, Imai T, Ozasa K, Motohashi Y, Matsuzaki I, Sasahara S, Hatta K, Ogino K, Eboshida A.
- Journal Title
  
  Int Arch Allergy Immunol 135・1
  
  Pages: 40-43
- Data Source
  KAKENHI-PROJECT-14370120
[Journal Article] Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with Japanese cedar pollinosis.2004
- Author(s)
  Nakamura, H., Higashikawa, F., Miyagawa, K., Nobukuni, Y., Endo, T., Imai, T., Ozasa, K., Motohashi, Y., Matsuzaki, I., Sasahara, S., Hatta, K., Ogino, k., Eboshida, A.
- Journal Title
  
  Int.Arch.Allergy Immunol. 135
  
  Pages: 40-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370120
[Journal Article] Induction of myeloperoxidase and nitrotyrosine formation in a human leukemia cell line, EoL-1.2004
- Author(s)
  Kodama N, Kambayashi Y, Kubo M, Yoneyama S, Nobukuni Y, Nakamura H, Ogino K.
- Journal Title
  
  Cell Biochem Funct 22・2
  
  Pages: 105-112
- Data Source
  KAKENHI-PROJECT-14370120
[Journal Article] Induction of myeloperoxidase and nitrotyrosine formation in a human eosinophilic leukemia cell line, EoL-1.2004
- Author(s)
  Kodama, N., Kambayashi, Y., Kubo, M., Yoneyama, S., Nobukuni, Y., Nakamura, H., Ogino, K.
- Journal Title
  
  Biochem.Funct. 22
  
  Pages: 105-112
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370120
[Presentation] 抗腫瘍活性物質･薬毒物感受性関連遺伝子群のゲノム機能学的探索法の開発2016
- Author(s)
  信國好俊、升本順子、沼本通孝、鍛冶利幸、好光健彦
- Organizer
  第43会日本毒性学会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 三酸化ヒ素感受性に関与する遺伝子群の探索と毒性発現機構について2015
- Author(s)
  信國好俊、升本順子、沼本通孝
- Organizer
  第14回分子予防環境医学研究会
- Place of Presentation
  大阪
- Year and Date
  2015-02-14
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 三酸化ヒ素感受性と発がん性の関連性について2015
- Author(s)
  信國好俊、升本順子、沼本通孝
- Organizer
  第85回日本衛生学会学術総会
- Place of Presentation
  和歌山
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 抗腫瘍活性物質感受性関連遺伝子群のゲノム機能学的包括的探索法の開発2015
- Author(s)
  信國好俊、升本順子、沼本通孝、好光健彦
- Organizer
  第42会日本毒性学会
- Place of Presentation
  金沢
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 抗腫瘍活性物質感受性関連遺伝子群のゲノム機能学的包括的探索法の開発2015
- Author(s)
  信國好俊、升本順子、沼本通孝、好光健彦
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 三酸化ヒ素感受性決定要因の多様性について2015
- Author(s)
  信國好俊、升本順子、沼本通孝
- Organizer
  第21回ヒ素シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2015-11-15
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 三酸化ヒ素毒性発現発現におけるシトクロムP450系の関与2014
- Author(s)
  信國好俊、升本順子
- Organizer
  第84回日本衛生学会学術総会
- Place of Presentation
  岡山
- Year and Date
  2014-05-27
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 抗腫瘍活性物質感受性に関与する遺伝子群のゲノム機能学的探索2014
- Author(s)
  信國好俊、升本順子、沼本通孝、好光健彦
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-03
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 三酸化ヒ素感受性関連遺伝子群の探索と活性酸素発生機構の検討2013
- Author(s)
  信國好俊、升本順子、沼本通孝
- Organizer
  第12回分子予防医学研究会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 有機カルコゲン化合物の細胞毒性2013
- Author(s)
  橋谷珠世,岡崎貴大,郡久美子,山本千夏,藤原泰之,信國好俊,栗田城治,鍜冶利幸
- Organizer
  フォーラム2013:衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Year and Date
  2013-09-13
- Data Source
  KAKENHI-PROJECT-23590156
[Presentation] 三酸化ヒ素感受性関連遺伝子群の探索とヒ素誘導性アポトーシスの検討2013
- Author(s)
  信國好俊、升本順子、沼本通孝
- Organizer
  第83回日本衛生学会学術総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] PI3 kinase negatively regulates apolipoprotein-dependent HDL generatio2012
- Author(s)
  Sumiko Abe-Dohmae, Yoshitaka Nobukuni, Narehiko Hayashi, Yoshiaki Marumo, Junko Masumoto, Shinji Yokoyama
- Organizer
  HDL Satellite Symposium 2012
- Place of Presentation
  Cairns, Australia
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] ヒ素感受性に関与する遺伝子群の探索とヒ素誘導性アポトーシスの検討2012
- Author(s)
  信國好俊、升本順子、沼本通孝
- Organizer
  第18回ヒ素シンポジウム
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] PI3 kinase negatively regulates apollpoprotein-dependent HDL generatio2012
- Author(s)
  Sumiko Abe-Dohmae, Yoshitaka Nobukuni, Narehiko Hayashi, Yoshiaki Marurao, Jyunko Masumoto, Shinji Yokoyama
- Organizer
  HDL Satellite Symposium 2012
- Place of Presentation
  Cairns, Australia
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] PI3 kinase inhibits HDL generation through reducing protein levels of ABCA1 and ABCA72012
- Author(s)
  Sumiko Abe-Dohmae, Yoshitaka Nobukuni, Narehiko Hayashi, Yoshiaki Marumo, Junko Masumoto, Shinji Yokoyama
- Organizer
  The 16th International Symposium on Atherosclerosis
- Place of Presentation
  Sydney, Australia
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] 細胞内コレステロール代謝輸送関連遺伝子群の探索と予防医学への応用2012
- Author(s)
  信國好俊、升本順子、堂前純子、林希彦、丸林義晃、横山信治
- Organizer
  第82回日本衛生学会学術総会
- Place of Presentation
  京都
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] 細胞内コレステロール代謝輸送におけるPIK3CA機能の解析2011
- Author(s)
  信國好俊、升本順子
- Organizer
  第81回日本衛生学会学術総会
- Place of Presentation
  (東京での予定であったが地震災害のため総会中止、紙上発表)
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] PI3キナーゼによるアポリポタンパク質依存性HDL新生反応の制御 Effect of PI3 kinase on apolipoprotein-mediated HDL generation2011
- Author(s)
  堂前純子、信國好俊、林希彦、丸茂義晃、升本順子、横山信治
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] PI3 kinase inhibits ABCA1- and ABCA7-mediated HDL generation through reducing their protein levels2011
- Author(s)
  Sumiko Abe-Dohmae, Yoshitaka Nobukuni, Narehiko Hayashi, Yoshiaki Marumo, Junko Masumoto, Shinji Yokoyama
- Organizer
  第43回日本動脈硬化学会総会・学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] 細胞内コレステロール代謝輸送におけるPIK3CA機能の解析2011
- Author(s)
  信國好俊、升本順子
- Organizer
  第81回日本衛生学会学術総会
- Place of Presentation
  (東京での予定であったが地震災害のため総会中止、紙上発表)
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] ヒ素感受性に関与する遺伝子群の探索2011
- Author(s)
  信國好俊、升本順子、安武章
- Organizer
  第16回ヒ素シンポジウム
- Place of Presentation
  旭川
- Year and Date
  2011-02-06
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] PI3キナーゼによるアポリポタンパク質依存性HDL新生反応の制御Effect of PI3 kinase on apolipoprotein-mediated HDL generation2011
- Author(s)
  堂前純子、信國好俊、林希彦、丸茂義晃、升本順子、横山信治
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] Functional genomics approach to identify the genes involved in hyperlipidemia2010
- Author(s)
  Yoshitaka Nobukuni, Junko Masumoto
- Organizer
  日本動脈硬化学会総会・学術集会
- Place of Presentation
  岐阜
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] ヒ素感受性に関与する遺伝子群解明への新たな試み2010
- Author(s)
  信國好俊
- Organizer
  第80回日本衛生学会学術総会シンポジウム
- Place of Presentation
  仙台(招待講演)
- Year and Date
  2010-05-09
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] 高脂血症発症関連遺伝子群の解明と予防医学への応用2010
- Author(s)
  信國好俊、升本順子、烏帽子田彰
- Organizer
  第80回日本衛生学会学術総会
- Place of Presentation
  仙台
- Year and Date
  2010-05-10
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] 高脂血症発症関連遺伝子群の解明と予防医学への応用2010
- Author(s)
  信國好俊、升本順子、烏帽子田彰
- Organizer
  第80回日本衛生学会学術総会
- Place of Presentation
  仙台
- Year and Date
  2010-05-10
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] ヒ素感受性に関与する遺伝子群解明への新たな試み2010
- Author(s)
  信國好俊
- Organizer
  第80回日本衛生学会学術総会シンポジウム
- Place of Presentation
  仙台(招待講演)
- Year and Date
  2010-05-09
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] ヒ素感受性に関与する遺伝子群解明への取り組み2009
- Author(s)
  信國好俊, 升本順子, 安武章
- Organizer
  第９回分子予防環境医学研究会
- Place of Presentation
  東京
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] ヒ素感受性に関与する遺伝子群解明への取り組み2009
- Author(s)
  信國好俊, 升本順子, 安武章
- Organizer
  第9回分子予防環境医学研究会
- Place of Presentation
  東京
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21390188
[Presentation] ゲノム機能学的解析による薬毒物感受性に関与する遺伝子群の解明：三酸化ヒ素およびAgelastatin A感受性関連遺伝子群の探索
- Author(s)
  信國好俊、升本順子、沼本通孝、好光健彦
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] Agelastatin Aの抗腫瘍作用と感受性に関与する遺伝子群の探索
- Author(s)
  信國好俊、升本順子、好光健彦
- Organizer
  第13回分子予防環境医学研究会
- Place of Presentation
  和歌山
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 三酸化ヒ素毒性発現におけるシトクロムP450系の関与
- Author(s)
  信國好俊、升本順子
- Organizer
  第84回日本衛生学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-24659301
[Presentation] 有機カルコゲン化合物の細胞毒性
- Author(s)
  橋谷珠世，岡崎貴大，郡久美子，山本千夏、藤原泰之，信國好俊，栗田城治，鍜冶利幸
- Organizer
  フォーラム2013衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-23590156

1. NAKAMURA Hiroyuki (30231476)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. KAMBAYASHI Yasuhiro (20345630)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. OGINO Keiki (70204104)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. DOUMAE Sumiko (70227700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. EBOSHIDA Akira (50168811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. FUJIMOTO Nariaki (40243612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAMOTO Chika (70230571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. YASUIKE Shuji (10230210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKEDA Junji (50163407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KATO Masashi (10281073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 石田万里 (30359898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 長瀬博文 (00251918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nobukuni Yoshitaka 信國 好俊

NOBUKUNI Yoshitaka 信國 好俊

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Functional genetic screening of the genes involved in the arsenite sensitivityPrincipal Investigator

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Modification of organometallic compound cytotoxicity by incorporated metal atoms and molecular mechanisms underlying the toxicity

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Clarification of the genes involved in the hyperlipidemia and the application to the preventive medicinePrincipal Investigator

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ジーントラップ法を用いた蛋白合成制御とその異常による発がん機構の解明Principal Investigator

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Generation mechanisms of nitrogen dioxide-like species from cardiovascular system.

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Study on preventing systems of fetus for uteroplacental circulatory disturbances and uteroplacental dysfunctions produced by microwaves

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ジーントラップ挿入変異ライブラリーを用いた高脂血症発症に関与する遺伝子群の同定Principal Investigator

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Functional and structural analyses of the ubiquitin conjugating enzyme UBE2I genePrincipal Investigator

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[Journal Article] Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 22005

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[Journal Article] Induction of myeloperoxidase and nitrotyrosine formation in a human eosinophilic leukemia cell line, Eol-1.2004

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[Journal Article] Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with Japanese cedar pollinosis.2004

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[Journal Article] Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with Japanese cedar pollinosis.2004

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[Journal Article] Induction of myeloperoxidase and nitrotyrosine formation in a human leukemia cell line, EoL-1.2004

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[Journal Article] Induction of myeloperoxidase and nitrotyrosine formation in a human eosinophilic leukemia cell line, EoL-1.2004

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Nobukuni Yoshitaka 信國好俊

NOBUKUNI Yoshitaka 信國好俊

[Presentation] 抗腫瘍活性物質感受性関連遺伝子群のゲノム機能学的包括的探索法の開発2015