熊本浩樹クマモトヒロキ

Researcher Number	80297019
Other IDs
Affiliation (Current)	2025: 日本薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 日本薬科大学, 薬学部, 准教授 2006 – 2007: 昭和大学, 薬学部, 講師 2004: 昭和大学, 薬学部, 講師 2003: 昭和大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator Basic Section 54030:Infectious disease medicine-related
Keywords	Principal Investigator SAHase / クロスカップリング / ビニルスタナン / 脱硫的スタニル化 / ラジカル反応 / ネプラノシンA / 炭素置換 / 抗HIV / スタニル化 / リチウム化 … More / d4T / 抗マラリア剤 / 抗HIV剤 / 脱硫的スタニル化反応 / 金属-スルホキシド交換反応 / スタニルマイグレーション / スタブジン / d4ヌクレオシド … More Except Principal Investigator 新規核酸系抗HBV化合物 / HBV / B型慢性肝炎 / cccDNA / ヒト肝キメラマウス / 抗ウイルス薬開発 / ヒトB型肝炎ウイルス / HBV感染症 Less

Does cccDNA depletion by complete blockage of HBV replication result in a cure for hepatitis B? -Elucidation using PXB mice model-
- Principal Investigator
  
  鍬田伸好 (東伸好)
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Center for Global Health and Medicine
新規SAHase 阻害剤;塩基部,糖部修飾型ヌクレオシドの合成と生物活性の探索Principal Investigator
- Principal Investigator
  
  熊本浩樹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
糖部2',3'炭素置換d4ヌクレオシドの新規合成法の開発と抗HIV活性の探索Principal Investigator
- Principal Investigator
  
  熊本浩樹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University

All 2023 2008 2007

All Journal Article Presentation

[Journal Article] Synthesis of (±)-9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-l-yl]-9H-adenine (BCA) derivatives branched at the 4'-position based on intramolecular SH2'-cyclization2008
- Author(s)
  熊本浩樹
- Journal Title
  
  Tetrahedron 64
  
  Pages: 1494-1505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790090
[Journal Article] Preparation of acyclic nucleoside phosphonate analogues based on cross-metathesis2008
- Author(s)
  熊本浩樹
- Journal Title
  
  Tetrahedron 64
  
  Pages: 3517-3526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790090
[Journal Article] Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation2007
- Author(s)
  熊本浩樹
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 145-146
- Data Source
  KAKENHI-PROJECT-18790090
[Journal Article] Synthesis of novel 4'-modified neplanocin A analogues and their inhibitory activity against S-adenosyl-L-homocysteine hydrolase2007
- Author(s)
  熊本浩樹
- Journal Title
  
  Nucleosides Nucleotides, Nucleic Acids 26
  
  Pages: 733-736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790090
[Presentation] 新規核酸系抗HBV化合物, E-CFCP,によるcccDNAの減衰/枯渇効果の検討2023
- Author(s)
  鍬田伸好, 林佐奈衣,熊本浩樹,青木宏美, 井本修平,田中靖人,満屋裕明
- Organizer
  第31回日本抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K27645
[Presentation] ラジカル閉環反応を鍵段階とする(±)-4'-炭素置換-bishydroxymethyl cyclopentenyl adenine (BCA)の合成と抗HIV作用の検討2007
- Author(s)
  熊本浩樹
- Organizer
  第17回抗ウイルス化学療法研究会
- Place of Presentation
  高松
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-18790090
[Presentation] Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation2007
- Author(s)
  熊本浩樹
- Organizer
  5th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-18790090
[Presentation] 脱硫的スタニル化反応を鍵とする新規5'-炭素置換ネプラノシンAおよびノルネプラノシンA類の合成2007
- Author(s)
  熊本浩樹
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2007-03-26
- Data Source
  KAKENHI-PROJECT-18790090
[Presentation] Radical-mediated Sulfur-extrusive stannylation: Application for the synthesis of novel neplanocin A analogues2007
- Author(s)
  熊本浩樹
- Organizer
  ational Conference on the Coordination and Organometallic Chemistry of Germanium,
- Place of Presentation
  Galway(ireland)
- Year and Date
  2007-07-12
- Data Source
  KAKENHI-PROJECT-18790090

1. 鍬田伸好 (60361218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 林佐奈衣 (10597587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 青木宏美 (90970351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 東伸好

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

熊本 浩樹 クマモト ヒロキ

Research Projects

Research Products

Co-Researchers

Does cccDNA depletion by complete blockage of HBV replication result in a cure for hepatitis B? -Elucidation using PXB mice model-

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規SAHase 阻害剤;塩基部,糖部修飾型ヌクレオシドの合成と生物活性の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

糖部2',3'炭素置換d4ヌクレオシドの新規合成法の開発と抗HIV活性の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthesis of (±)-9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-l-yl]-9H-adenine (BCA) derivatives branched at the 4'-position based on intramolecular SH2'-cyclization2008

Author(s)

Journal Title

Data Source

[Journal Article] Preparation of acyclic nucleoside phosphonate analogues based on cross-metathesis2008

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation2007

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of novel 4'-modified neplanocin A analogues and their inhibitory activity against S-adenosyl-L-homocysteine hydrolase2007

Author(s)

Journal Title

Data Source

[Presentation] 新規核酸系抗HBV化合物, E-CFCP,によるcccDNAの減衰/枯渇効果の検討2023

Author(s)

Organizer

Data Source

[Presentation] ラジカル閉環反応を鍵段階とする(±)-4'-炭素置換-bishydroxymethyl cyclopentenyl adenine (BCA)の合成と抗HIV作用の検討2007

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation2007

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 脱硫的スタニル化反応を鍵とする新規5'-炭素置換ネプラノシンAおよびノルネプラノシンA類の合成2007

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Radical-mediated Sulfur-extrusive stannylation: Application for the synthesis of novel neplanocin A analogues2007

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

熊本浩樹クマモトヒロキ