Saiki Yuriko 齋木由利子

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SAIKI Yuriko 齋木由利子

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Researcher Number	80311223
Other IDs
Affiliation (Current)	2025: 東北大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 東北大学, 医学系研究科, 准教授 2018: 東北大学, 医学系研究科, 准教授 2016 – 2017: 東北大学, 医学系研究科, 助教 2013 – 2015: 東北大学, 医学(系)研究科(研究院), 助教 2002: The Cancer Institute, Department of Carcinogenesis, Associate, 癌研究所・発がん研究部, 研究員 2001: 財団法人癌研究会, 癌研究所・発がん研究部, 研究員 2000: (財)癌研究会, 癌研究所・発がん研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 49020:Human pathology-related / Digestive surgery Except Principal Investigator Otorhinolaryngology / Cardiovascular surgery / Pathological medical chemistry
Keywords	Principal Investigator Dusp6 / 非アルコール性脂肪肝 / Cyp4A / NAFLD / モデルマウス / DUSP6 / 膵がんマウスモデル / 発がんモデルマウス / 膵臓がん / マウスモデル … More / 膵がん / 腫瘍抑制因子 / ERK / pancreatic cancer / マイクロRNA / エピジェネティクス / タキサン耐性 / head and neck cancer / esophagel cancer / ABCB1 / chemosensitivity / microRNA / esophageal cancer … More Except Principal Investigator 頭頸部癌 / マイクロＲＮＡ / マイクロRNA / アポトーシス / PPAR-γ / 肺動脈性肺高血圧 / 肺高血圧 / 肺静脈狭窄症 / 肺血管病変 / 肺高血圧症 / 肺生検 / 肺動脈性肺高血圧症 / 先天性心疾患 / microRNA / リンパ節転移 / マウス / 遠隔転移 / 頭頸部外科学 / 非扁平上皮癌 / がん関連蛋白 / DIGR method / EWS -ATF1 / EWS -FLI1 / transcriptional regulation / clear cell sarcoma / Ewing sarcoma / target gene / chimeric transcription factor / 転写因子 / 標的遣伝子 / DIGR法 / EWS-ATF1 / EWS-FLI1 / 転写調節 / 明細胞肉腫 / Ewing肉腫 / 標的遺伝子 / キメラ型転写因子 / マイクロアレイ / トランスレーショナルリサーチ / 癌 / 質量分析計 / 血清マーカー / ヒト乳頭腫ウイルス / 中咽頭癌 / 原発不明頭頸部癌 / 鼻副鼻腔癌 / 鼻副鼻腔内反性乳頭腫 / ヒトパピローマウイルス / HPV Less

二重特異性フォスファターゼ６（DUSP6)の非アルコール性肝炎における役割の解明Principal Investigator
- Principal Investigator
  
  齋木由利子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tohoku University
Treatment Strategies for DUSP6 Inactivated Pancreatic CancerPrincipal Investigator
- Principal Investigator
  
  Saiki Yuriko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Tohoku University
Identification of novel therapeutic markers of head and neck non-squamous cell carcinoma
- Principal Investigator
  
  Kato Kengo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tohoku University
Identification of microRNAs associated with distant metastasis in model mouse
- Principal Investigator
  
  Sagai Shun
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tohoku University
Clarification of the mechanism of pulmonary arteriopathy associated with congenital heart diseases and development of new treatment using lung biopsy speciments
- Principal Investigator
  
  Saiki Yoshikatsu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Tohoku University
Chemosensitivity and microRNA signature in esophageal cancerPrincipal Investigator
- Principal Investigator
  
  Saiki Yuriko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Identification of serum and salivary markers of head and neck cancers by mass spectrometer
- Principal Investigator
  
  Ogawa Takenori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tohoku University
Analysis of abnormal micro RNA expression associated with HPV-related head and neck carcinogenesis and prognosis using microarray.
- Principal Investigator
  
  Ishida Eiichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tohoku University
Identification of target genes for chimeric transcription factors in malignant mesenchymal tumors
- Principal Investigator
  
  NAKAMURA Takuro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Japanese Foundation for Cancer Research

All 2023 2022 2021 2018 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Ablation of Dual-Specificity Phosphatase 6 Protects against Nonalcoholic Fatty Liver Disease via Cytochrome P450 4A and Mitogen-Activated Protein Kinase2023
- Author(s)
  Jiang Can、Saiki Yuriko、Hirota Shuto、Iwata Kosei、Wang Xinyue、Ito Yutaka、Murakami Keigo、Imura Takehiro、Inoue Jun、Masamune Atsushi、Hirayama Akiyoshi、Goto Masafumi、Furukawa Toru
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 193 Issue: 12 Pages: 1988-2000
- DOI
  10.1016/j.ajpath.2023.09.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06477
[Journal Article] Genetic Mutations of Pancreatic Cancer and Genetically Engineered Mouse Models2021
- Author(s)
  Saiki Yuriko、Jiang Can、Ohmuraya Masaki、Furukawa Toru
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 1 Pages: 71-71
- DOI
  10.3390/cancers14010071
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08405, KAKENHI-PROJECT-20K07386
[Journal Article] Evidence of Pulmonary Vascular Reverse Remodeling After Pulmonary Artery Banding Performed in Early Infancy in Patients With Congenital Heart Defects2018
- Author(s)
  Masaki Naoki、Saiki Yuriko、Endo Masato、Maeda Kay、Adachi Osamu、Akiyama Masatoshi、Kawamoto Shunsuke、Saiki Yoshikatsu
- Journal Title
  
  Circ J
  
  Volume: 82 Issue: 3 Pages: 684-690
- DOI
  10.1253/circj.CJ-17-0379
- NAID
  130006394538
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Data Source
  KAKENHI-PROJECT-16K15627
[Journal Article] Is Trisomy 21 a Risk Factor for Rapid Progression of Pulmonary Arteriopathy?　― Revisiting Histopathological Characteristics Using 282 Lung Biopsy Specimens ―2018
- Author(s)
  Masaki Naoki、Saiki Yuriko、Endo Masato、Maeda Kay、Adachi Osamu、Akiyama Masatoshi、Kawamoto Shunsuke、Saiki Yoshikatsu
- Journal Title
  
  Circ J
  
  Volume: 82 Issue: 6 Pages: 1682-1687
- DOI
  10.1253/circj.CJ-17-0754
- NAID
  130006744320
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2018-05-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15627
[Journal Article] Surgical technique for allogeneic uterus transplantation in macaques2016
- Author(s)
  Obara H, Kisu I, Kato Y, Yamada Y, Matsubara K, Emoto K, Adachi M, Matoba Y, Umene K, Nogami Y, Banno K, Tsuchiya H, Itagaki I, Kawamoto I, Nakagawa T, Ishigak Hi, Itoh Y, Ogasawara K, Saiki Y, Sato S-i, Nakagawa N, Shiina T, Aoki D, Kitagawa Y
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 35989-35989
- DOI
  10.1038/srep35989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26640053, KAKENHI-PROJECT-15K10084
[Journal Article] Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK.2015
- Author(s)
  Nakano T, Saiki Y, Kudo C, Hirayama A, Mizuguchi Y, Fujiwara S, Soga T, Sunamura M, Matsumura N, Motoi F, Unno M, Horii A.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 464 Issue: 4 Pages: 1084-1089
- DOI
  10.1016/j.bbrc.2015.07.080
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460468, KAKENHI-PROJECT-25462673
[Journal Article] S100A4 is frequently overexpressed in lung cancer cells and promotes cell growth and cell motility.2014
- Author(s)
  Chen N, Sato D, Saiki Y, Sunamura M, Fukushige S, Horii A
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 447(3) Pages: 459-464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462673
[Journal Article] Molecular pathology of pancreatic cancer.2014
- Author(s)
  Saiki Y, Horii A.
- Journal Title
  
  Pathol Int
  
  Volume: 64 Issue: 1 Pages: 10-19
- DOI
  10.1111/pin.12114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-25462673
[Journal Article] The expression of S100A4 in human pancreatic cancer is associated with invasion2013
- Author(s)
  Tsukamoto N, et al
- Journal Title
  
  Pancreas
  
  Volume: 42(6) Issue: 6 Pages: 1027-33
- DOI
  10.1097/mpa.0b013e31828804e7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390253, KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-25462673
[Journal Article] Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer2013
- Author(s)
  Yamamura A, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 441(1) Issue: 1 Pages: 102-7
- DOI
  10.1016/j.bbrc.2013.10.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390253, KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-24590471, KAKENHI-PUBLICLY-25118720, KAKENHI-PROJECT-25293081, KAKENHI-PROJECT-25462673
[Presentation] The role of the DUSP6/CYP4A axis in the pathogenesis of nonalcoholic fatty liver disease.2023
- Author(s)
  Yuriko Saiki1, Can Jiang1, Shuto Hirota1, Kengo Murakami1, Toru Furkawa1
- Organizer
  The 112 th Annual Meeting fo the Japanese Society of Pathology
- Data Source
  KAKENHI-PROJECT-23K06477
[Presentation] 16)Dual specificity phosphatase 6 deficiency improves insulin sensitivity and protects against obesity in mice2022
- Author(s)
  Can Jiang, Yuriko Saiki, Toru Furukawa.
- Organizer
  International Association of Pancreatology and Japan Pancreas Society Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07386
[Presentation] 17)Loss of Dusp6 enhance the KrasG12D-driven pancreatic carcinogenesis2022
- Author(s)
  Akiyuki Sasaki,Yuriko Saiki, Jiang Can, Toru Furukawa
- Organizer
  JCA-AACR Conference on Advances in Pancreatic Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07386
[Presentation] The role of Human papilloma virus type 16 associated with malignant transformation of sinonasal squamous cell carcinoma2016
- Author(s)
  Takenori Ogawa,Eiichi Ishida,Kenjiro Higashi,Yuriko Saiki,Shun Sagai,Ayako Nakanome,Akira Okoshi,Masayuki Shirakura,Yukio Katori,Akira Horii
- Organizer
  World Skull Base 2016
- Place of Presentation
  Osaka, Osaka international convention center
- Year and Date
  2016-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462673
[Presentation] ABCB1 in side populations is a key ABC transporter essential for acquired taxane-chemoresistance in esophageal cancer cells2015
- Author(s)
  齋木由利子
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際展示場（名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K10084

1. Ogawa TAKENORI (50375060)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
2. HORII Akira (40249983)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
3. Ishida Eiichi (50644811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. NAKAMURA Takuro (00180373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Takeuchi Hiroya (20265838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Sunamura Makoto (10201584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Kato Kengo (40455788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Sagai Shun (90375014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Saiki Yoshikatsu (50372298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 小玉哲也 (40271986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 森士朗 (80230069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 川本俊輔 (20400244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 遠藤雅人 (90282128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 古川徹 (30282122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. OHMURAYA Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. TSUCHIYA Hideaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 伊藤靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 小笠原一誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saiki Yuriko 齋木 由利子

SAIKI Yuriko 齋木 由利子

Research Projects

Research Products

Co-Researchers

二重特異性フォスファターゼ６（DUSP6)の非アルコール性肝炎における役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Treatment Strategies for DUSP6 Inactivated Pancreatic CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel therapeutic markers of head and neck non-squamous cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of microRNAs associated with distant metastasis in model mouse

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of the mechanism of pulmonary arteriopathy associated with congenital heart diseases and development of new treatment using lung biopsy speciments

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemosensitivity and microRNA signature in esophageal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of serum and salivary markers of head and neck cancers by mass spectrometer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of abnormal micro RNA expression associated with HPV-related head and neck carcinogenesis and prognosis using microarray.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of target genes for chimeric transcription factors in malignant mesenchymal tumors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Ablation of Dual-Specificity Phosphatase 6 Protects against Nonalcoholic Fatty Liver Disease via Cytochrome P450 4A and Mitogen-Activated Protein Kinase2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic Mutations of Pancreatic Cancer and Genetically Engineered Mouse Models2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evidence of Pulmonary Vascular Reverse Remodeling After Pulmonary Artery Banding Performed in Early Infancy in Patients With Congenital Heart Defects2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Is Trisomy 21 a Risk Factor for Rapid Progression of Pulmonary Arteriopathy? ― Revisiting Histopathological Characteristics Using 282 Lung Biopsy Specimens ―2018

Author(s)

Journal Title

Saiki Yuriko 齋木由利子

SAIKI Yuriko 齋木由利子

[Journal Article] Is Trisomy 21 a Risk Factor for Rapid Progression of Pulmonary Arteriopathy?　― Revisiting Histopathological Characteristics Using 282 Lung Biopsy Specimens ―2018