Hosaka Masahiro 穂坂正博

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HOSAKA Masahiro 穂坂正博

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Researcher Number	80311603
Other IDs	https://orcid.org/0000-0002-1422-1774
Affiliation (Current)	2025: 秋田県立大学, 生物資源科学部, 教授
Affiliation (based on the past Project Information) *help	2011 – 2024: 秋田県立大学, 生物資源科学部, 教授 2007 – 2010: Gunma University, Institute for Molecular & Cellular Regulation, Department of Molecular Medicine, Associate Professor 2003 – 2006: 群馬大学, 生体調節研究所, 助教授 1999 – 2002: 群馬大学, 生体調節研究所, 講師
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Neuroscience in general / Neurochemistry/Neuropharmacology / Functional biochemistry / Basic Section 38030:Applied biochemistry-related / Chemical biology / Applied pharmacology / Biological Sciences Except Principal Investigator General anatomy (including Histology/Embryology) / Basic Section 48010:Anatomy-related / General anatomy (including histology/embryology) / Biomedical engineering/Biological material science
Keywords	Principal Investigator 分泌顆粒 / ペプチドホルモン / 選別輸送 / コレステロール / ATPase / 内分泌細胞 / 神経内分泌細胞 / セクレトグラニンIII / グラニンタンパク質 / プロセッシング酵素 … More / cholesterol / secretogranin III / secretory granule / Synapsin / シナプシン / イリジウム錯体 / イメージング / 顆粒膜 / プロホルモン / カルボキシペプチターゼE / セレクトグラニンIII / セクレトグラニン / ホルモン修飾酵素 / 酸素応答 / NASH / 非アルコール性脂肪性肝炎 / peptide hormones / sorting / lipid composition / synaptic-like micro-vesicle / neuroendocrine cells / pHプローブ / 選別輪送 / 脂質組成 / 神経様小胞 / carboxypeptidase E / sorting mechanism / neuro-peptide / peptide-hormone / neuroendocrine cell / リピッドラフト / スフィンゴリピッド / リポソーム / 神経ペプチド / Secretory Granules / Secretogranin III / Chromogranin A / Synaptic Vesicles / セレクトグラニン / クロモグラニン / Sensory nerve ending / Cyclosporine A / Phosphorylation / Dimerization / 小胞輸送 / 神経 / 末梢神経 / サイクロスポリンA / リン酸化 / 二量体 / ホルモン分泌 / 膜脂質組成 / ホルモンと生理活性物質 / 可視化 / 腫瘍 / 低酸素病態 / 脂質 / 神経分泌細胞 / トランスゴルジネットワーク … More Except Principal Investigator ゴルジ装置 / 免疫組織化学 / 電子顕微鏡観察 / 性腺刺激ホルモン産生細胞 / 下垂体前葉 / 細胞内小胞輸送 / コルヒチン / 細胞極性 / 中心小体 / 微小管 / 電子顕微鏡 / 分泌顆粒 / 内分泌細胞 / 視床下部 / 下垂体後葉 / 生活習慣病 / ストレス応答 / 膵島β細胞 / プロセシング / ホルモン分泌調節 / グラニン蛋白 / ホルモン分泌 / 分泌経路 / 実験内分泌学 / 分泌細胞 / 微小管構築 / 甲状腺濾胞上皮細胞 / 実験内分泌学的動物モデル / 分泌顆粒形成 / 深達度 / 長波長化 / 癌の面像診断 / 酸素濃度 / 二色発光 / 癌の画像診断 / In vivoイメージング / 酸素消光 / リン光 / 発光プローブ / 低酸素病態 / イリジウム錯体 / 有機EL / 分子イメージング / ホルモン療法 / 粗面小胞体 / 細胞内膜系小器官 / leuprorelin / LHRH誘導体 Less

セクレトグラニンに依存しない分泌顆粒へのホルモン選別輸送機構を探索するPrincipal Investigator
- Principal Investigator
  
  穂坂正博
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Akita Prefectural University
Sorting mechanism of processing enzymes to the secretory granules.Principal Investigator
- Principal Investigator
  
  Masahiro Hosaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Akita Prefectural University
Physiological significance of the granin protein family in the endocrine function, revealed by analyzing the phenotypes of newly established Sg2- and Sg3-deficient mice.
- Principal Investigator
  
  Watanabe Tsuyoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Asahikawa Medical College
Oxygen response in neuro-endocrine cells.Principal Investigator
- Principal Investigator
  
  Hosaka Masahiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Akita Prefectural University
non-alcoholic steatohepatitis imaging with iridium cpmplexesPrincipal Investigator
- Principal Investigator
  
  Hosaka Masahiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  Akita Prefectural University
Diversity in the global organization of the Golgi apparatus in differentiated secretory cells.
- Principal Investigator
  
  WATANABE Tsuyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Asahikawa Medical College
Study for protein binding to the cholesterol-rich secretory granule membrane in neuroendocrine cellsPrincipal Investigator
- Principal Investigator
  
  HOSAKA Masahiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Akita Prefectural University
The cholesterol metabolism of neuroendocrine cells and crosstalk of the hormone secretionPrincipal Investigator
- Principal Investigator
  
  HOSAKA Masahiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Akita Prefectural University
  Gunma University
Characteristics in the overall organization and dynamics of the Golgi apparatus in the anterior pituitary endocrine cells.
- Principal Investigator
  
  WATANABE Tsuyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Asahikawa Medical College
Phosphorescent Light-emitting lridium Complexes Serve as a Hypoxia-sensing Probe for Tumor Imaging in Living Animals.Principal Investigator
- Principal Investigator
  
  HOSAKA Masahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Applied pharmacology
- Research Institution
  Akita Prefectural University
  Gunma University
Research and development of hypoxia-detecting luminescent probe iridium complex and its application to endoscopic imaging probes
- Principal Investigator
  
  TAKEUCHI Toshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Gunma University
Effects of LHRH analogues on the ultrastructure of male rat pituitary gonadotropes
- Principal Investigator
  
  WATANABE Tsuyoshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Asahikawa Medical College
The formation mechanisms of secretory granules and synaptic-like micro-vesicles by the lead of cholesterol in endocrine cells.Principal Investigator
- Principal Investigator
  
  HOSAKA Masahiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Gunma University
神経内分泌細胞の調節性分泌経路へのタンパク質選別輸送機構の解明Principal Investigator
- Principal Investigator
  
  穂坂正博
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
A study for the sorting mechanism of proteins to Secretory Granules in Neuroendocrine cells : Emerging Concepts with Granins.Principal Investigator
- Principal Investigator
  
  HOSAKA Masanori
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Gunma University
The study for the function of synapsins in Synaptic vesicles and secretory granulesPrincipal Investigator
- Principal Investigator
  
  HOSAKA Masahiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Gunma University
Roles for Synapsins in Regulation of Synaptic Vesicle Traffic.Principal Investigator
- Principal Investigator
  
  HOSAKA Masahiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Gunma University

[Book] 実験医学増刊Vol.30 No.72012
- Author(s)
  飛田成史、吉原利忠、穂坂正博、竹内利行
- Total Pages
  226
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22570133
[Book] 疾患克服をめざしたケミカルバイオロジー; りん光プローブの設計・開発に基づくin vivo低酸素環境イメージング2012
- Author(s)
  飛田成史、吉原利忠、穂坂正博、竹内利行
- Publisher
  実験医学増刊
- Data Source
  KAKENHI-PROJECT-22570133
[Book] 実験医学増刊Vol. 30 N0. 7, リン光プローブの設計・開発に基づくin vivo低酸素環境イメージング2012
- Author(s)
  飛田成史, 吉原利忠, 穂坂正博, 竹内利行
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21200077
[Book] リン光プローブの設計・開発に基づくin vivo低酸素環境イメージング2012
- Author(s)
  飛田成史、吉原利忠, 穂坂正博、竹内利行
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21300159
[Book] 第一線の科学者が語る生活習慣病研究の最前線―メタボ・老化・がん研究からiPS細胞まで2012
- Author(s)
  北村忠弘、北川浩史、　穂坂正博、小島至　著
- Total Pages
  69
- Publisher
  上毛新聞社
- Data Source
  KAKENHI-PROJECT-22570133
[Book] リン光プローブの設計・開発に基づくin vivo低酸素環境イメージング2012
- Author(s)
  飛田成史, 吉原利忠, 穂坂正博, 竹内利行
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21300159
[Book] 実験医学増刊Vol.30 No.72012
- Author(s)
  飛田成史、吉原利忠、穂坂正博、竹内利行
- Total Pages
  226
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21200077
[Book] Medical Science Digest 35, りん光分子プローブを用いた癌環境イメージング-低酸素の可視化2009
- Author(s)
  飛田成史, 吉原利忠, 穂坂正博, 竹内利行
- Data Source
  KAKENHI-PROJECT-21200077
[Book] 第一線の科学者が語る生活習慣病研究の最前線-メタボ・老化・がん研究から iPS細胞まで
- Author(s)
  北村忠弘、北川浩史、穂坂正博、小島至著
- Publisher
  上毛新聞社
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Phogrin Regulates High-Fat Diet-Induced Compensatory Pancreatic β-Cell Growth by Switching Binding Partners2024
- Author(s)
  Kubota Chisato、Torii Ryoko、Hosaka Masahiro、Takeuchi Toshiyuki、Gomi Hiroshi、Torii Seiji
- Journal Title
  
  Nutrients
  
  Volume: 16 Issue: 1 Pages: 169-169
- DOI
  10.3390/nu16010169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06070
[Journal Article] Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene2023
- Author(s)
  Yasui Tadashi、Mashiko Mutsumi、Obi Akihiro、Mori Hiroyuki、Ito-Murata Moeko、Hayakawa Hiroki、Kikuchi Shota、Hosaka Masahiro、Kubota Chisato、Torii Seiji、Gomi Hiroshi
- Journal Title
  
  Histochemistry and Cell Biology
  
  Volume: 161 Issue: 3 Pages: 223-238
- DOI
  10.1007/s00418-023-02256-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06070
[Journal Article] Differential Expression of Secretogranins II and III in Canine Adrenal Chromaffin Cells and Pheochromocytomas2022
- Author(s)
  Gomi Hiroshi、Nagumo Takahiro、Asano Kazushi、Konosu Makoto、Yasui Tadashi、Torii Seiji、Hosaka Masahiro
- Journal Title
  
  Journal of Histochemistry & Cytochemistry
  
  Volume: 70 Issue: 5 Pages: 335-356
- DOI
  10.1369/00221554221091000
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05310, KAKENHI-PROJECT-20K06418, KAKENHI-PROJECT-21K06070, KAKENHI-PROJECT-22H04922
[Journal Article] Expression pattern of the LacZ reporter in secretogranin III gene-trapped mice2021
- Author(s)
  Hiroshi Gomi, Airi Hinata, Tadashi Yasui, Seiji Torii, Masahiro Hosaka
- Journal Title
  
  Journal of Histochemistry & Cytochemistry
  
  Volume: 69(4) Issue: 4 Pages: 229-243
- DOI
  10.1369/0022155421996845
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06418, KAKENHI-PUBLICLY-20H05310, KAKENHI-PROJECT-17K08528, KAKENHI-PROJECT-18K05443, KAKENHI-PROJECT-21K06070
[Journal Article] Culture in 10% O2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of processing enzymes2019
- Author(s)
  Sato E, Maeda Y, Sato Y, Hinata A, Gomi H, Koga D, Torii S, Watanabe T, Hosaka M
- Journal Title
  
  Biochem. J.
  
  Volume: 476 Issue: 5 Pages: 827-842
- DOI
  10.1042/bcj20180832
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08458, KAKENHI-PROJECT-17K08528, KAKENHI-PROJECT-18K05443, KAKENHI-PROJECT-16K08078, KAKENHI-PROJECT-17K08505
[Journal Article] Oxygen Imaging of Living Cells and Tissues Using Luminescent Molecular Probes2017
- Author(s)
  T. Yoshihara, Y. Hirakawa, M. Hosaka, M. Nangaku and S. Tobita
- Journal Title
  
  J. Photochem. Photobiol. C: Photochem. Rev.
  
  Volume: 30 Pages: 71-95
- DOI
  10.1016/j.jphotochemrev.2017.01.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26702011, KAKENHI-PROJECT-16K13103, KAKENHI-PLANNED-26111012
[Journal Article] TORC1 activity is partially reduced under nitrogen starvation conditions in sake yeast Kyokai no. 7, Saccharomyces cerevisiae.2016
- Author(s)
  Nakazawa N., Sato A., Hosaka M.
- Journal Title
  
  J Biosci Bioeng.
  
  Volume: 121 Issue: 3 Pages: 247-252
- DOI
  10.1016/j.jbiosc.2015.07.002
- NAID
  110010051474
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440052
[Journal Article] Mitochondria-targeted oxygen probes based on cationic iridium complexes with a 5-amino-1, 10-phenanthroline ligand.2015
- Author(s)
  Yoshihara T., Murayama S., Masuda T., Kikuchi T., Yoshida K., Hosaka M., Tobita S.
- Journal Title
  
  Journal of Photochemistry and Photobiology A: Chemistry
  
  Volume: 299 Pages: 172-182
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25440052
[Journal Article] Expression of Secretogranin III in Chicken Endocrine Cells: Its Relevance to the Secretory Granule Properties of Peptide Prohormone Processing and Bioactive Amine Content.2015
- Author(s)
  Gomi H, Morikawa S, Shinmura N, Moki H, Yasui T, Tsukise A, Torii S, Watanabe T, Maeda Y, Hosaka M
- Journal Title
  
  J Histochem Cytochem
  
  Volume: 印刷中 Issue: 5 Pages: 350-366
- DOI
  10.1369/0022155415575032
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390050, KAKENHI-PROJECT-25440052, KAKENHI-PROJECT-25450471
[Journal Article] Intracellular and in vivo oxygen sensing using phosphorescent Ir(III) complexes with a modified acetylacetonato ligand2015
- Author(s)
  Yoshihara T, Hosaka M, Terata M, Ichikawa K, Murayama S, Tanaka A, Mori M, Itabashi H, Takeuchi T, Tobita S.
- Journal Title
  
  Anal. Chem.
  
  Volume: 87 Issue: 5 Pages: 2710-2717
- DOI
  10.1021/ac5040067
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23310157, KAKENHI-PROJECT-24651256, KAKENHI-PROJECT-25440052, KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-26702011
[Journal Article] Silylation Improves the Photodynamic Activity of Tetraphenylporphyrin Derivatives In Vitro and In Vivo.2014
- Author(s)
  Horiuchi H., Hosaka M, Mashio H., Terata M., Ishida S., Kyusin S., Okutsu T., Takeuchi T., Hiratsuka H.
- Journal Title
  
  Chemistry
  
  Volume: 20 Pages: 6054-6060
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440052
[Journal Article] Functional Implications of the Golgi and Microtubular Network in Gonadotropes2014
- Author(s)
  ②Watanabe T, Bochimoto H, Koga D, Hosaka M, Ushiki T
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: vol.385(1-2) Issue: 1-2 Pages: 88-96
- DOI
  10.1016/j.mce.2013.10.003
- NAID
  120005496543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890012, KAKENHI-PROJECT-25440052
[Journal Article] Silylation improves photodynamic activity of tetraphenylporphyrin derivative in vitro and in vivo.2014
- Author(s)
  Horiuch H, Hosaka M, Mashio H,Ishida S, Kyushin S, Okutsu T, Takeuchi T, Hiratsuka H.
- Journal Title
  
  Chemistry - A European J
  
  Volume: 20 Issue: 20 Pages: 1-8
- DOI
  10.1002/chem.201303120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24651256, KAKENHI-PROJECT-24655137, KAKENHI-PROJECT-25410083, KAKENHI-PROJECT-25440052, KAKENHI-PROJECT-26620023
[Journal Article] Functional Implications of the Golgi and Microtubular Network in Gonadotropes.2014
- Author(s)
  Watanabe, T., Bochimoto, H., Koga, D., Hosaka, M., Ushiki, T.
- Journal Title
  
  Mol Cell Endocrinol.
  
  Volume: 385 Pages: 88-96
- NAID
  120005496543
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440052
[Journal Article] Multiple sorting systems for secretory granules ensure the regulated secretion of peotide hormones2013
- Author(s)
  Sun, M., Watanabe, T., Bochimoto, H., Sakai, Y., Torii, S., Takeuchi, T., Hosaka, M.
- Journal Title
  
  Traffic
  
  Volume: 14 Pages: 205-218
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Multiple sorting systems for secretory granules ensure the regulated secretion of peptide hormones.2013
- Author(s)
  Sun M
- Journal Title
  
  Traffic
  
  Volume: 14 Issue: 2 Pages: 205-218
- DOI
  10.1111/tra.12029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689007, KAKENHI-PROJECT-22570133, KAKENHI-PROJECT-22590185, KAKENHI-PROJECT-24890012, KAKENHI-PROJECT-25440052
[Journal Article] Chronic exercise enhances insulin secretion ability of pancreatic islets without change in insulin content in non-diabetic rats2013
- Author(s)
  Tsuchiya, M., Manabe Y., Yamada, K., Furuichi, Y., Hosaka, M., Fujii, N.
- Journal Title
  
  BBRC
  
  Volume: 430 Pages: 676-682
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Chronic exercise enhances insulin secretion ability of pancreatic islets without change in insulin content in non-diabetic rats.2013
- Author(s)
  Tsuchiya M, Manabe Y, Yamada K, Furuichi Y, Hosaka M, Fujii NL.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 11 Issue: 2 Pages: 676-682
- DOI
  10.1016/j.bbrc.2012.11.092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00173, KAKENHI-PROJECT-22570133, KAKENHI-PROJECT-24700700, KAKENHI-PROJECT-25440052
[Journal Article] Intact structure of EGAM1 homeoproteins and basic amino acid residues in the common homeodomain of EGAM1 and EGAM1C contribute to their nuclear localization in mouse embryonic stem cells.2013
- Author(s)
  Sato, S., Morita, S., Iha, M., Mori, Y., Sugawara, S., Kasuga, K., Kojima, I., Ozaki, N., Muraguchi, H., Okano, K., Iwashita, J., Murata, J., Hosaka, M., Kobayashi, M.
- Journal Title
  
  J Biosci Bioeng
  
  Volume: S1389-1723 Issue: 2 Pages: 49-2
- DOI
  10.1016/j.jbiosc.2013.02.007
- NAID
  110009657192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570238, KAKENHI-PROJECT-24580413, KAKENHI-PROJECT-25440052
[Journal Article] A unique ball-shaped Golgi apparatus in the rat pituitary gonadotrope: its functional implications in relation to the arrangement of the microtubule network.2012
- Author(s)
  Watanabe T, Sakai Y, Koga D, Bochimoto H, Hira Y, Hosaka M, Ushiki T.
- Journal Title
  
  J Histochem Cytochem.
  
  Volume: 60 Issue: 8 Pages: 588-602
- DOI
  10.1369/0022155412448791
- NAID
  120006522770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570133, KAKENHI-PROJECT-22590185
[Journal Article] Iridium Complex Probes for Monitoring of Cellular Oxygen Levels and Imaging of Hypoxic Tissues.2012
- Author(s)
  Yoshihara, T., Kobayashi, A., Oda, M., Hosaka, M., Takeuchi, T., Tobita, S.
- Journal Title
  
  Proc. SPIE
  
  Volume: 8233
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] A unique ball-shapeed Golgi apparatus in the rat pituitary ganadotrope: its functional implications in relation to the arrangement of microtuble network2012
- Author(s)
  Watanabe, T., Sakai, Y., Koga, D., Bochimoto, H., Hira, Y., Hosaka, M., Ushiki, T.
- Journal Title
  
  J. Histochem. Cytochem
  
  Volume: 60 Pages: 588-602
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Ratiometric Molecular Sensor for Monitoring Oxygen Levels in Living Cells2012
- Author(s)
  Yoshihara, T., Yamaguchi, Y., Hosaka, M., Takeuchi, T., Tobita, S.
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 51 Pages: 4418-4151
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Iridium Complex Probes for Monitoring of Cellular Oxygen Levels and Imaging of Hypoxic Tissues2012
- Author(s)
  Yoshihara, T., Kobayashi, A., Oda, M., Hosaka, M., Takeuchi, T., Tobita, S.
- Journal Title
  
  Proc.SPIE
  
  Volume: 8233 Pages: 82330A-82330A
- DOI
  10.1117/12.910170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200077, KAKENHI-PROJECT-23500511
[Journal Article] Ratiometric Molecular Sensor for Monitoring Oxygen Levels in Living Cells2012
- Author(s)
  Yoshihara, T., Yamaguchi, Y., Hosaka, M., Takeuchi, T., Tobita, S.
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 51 Issue: 17 Pages: 4148-4151
- DOI
  10.1002/anie.201107557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200077, KAKENHI-PROJECT-21300159, KAKENHI-PROJECT-23500511, KAKENHI-PROJECT-24651256
[Journal Article] Ratiometric Molecular Sensor for Monitoring Oxygen Levels in Living Cells.2012
- Author(s)
  Yoshihara, T., Yamaguchi, Y. , Hosaka, M., Takeuchi, T., Tobita, S.
- Journal Title
  
  Angew Chem Int Ed Engl.
  
  Volume: 51 Pages: 4148-4151
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] A radiometric molecular sensor for monitoring oxygen levels of living cells2012
- Author(s)
  Yoshihara T, Yamaguchi Y, Hosaka M, Takeuchi T, Tobita S
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 51 Pages: 4148-4151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300159
[Journal Article] Development of Iridium(III) Complexes with High Cellular Uptake Efficiency2011
- Author(s)
  Yoshihara, T., Ichikawa, K., Hosaka, M., Takeuchi, T., Tobita, S.
- Journal Title
  
  Photomedicine and Photobiology
  
  Volume: 33 Pages: 15-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages2011
- Author(s)
  Yamaguchi, R., Hosaka, M., Torii, S., Hou, N., Saito, N., Yoshimoto, Y., Imai., H., Takeuchi, T.
- Journal Title
  
  Brain Res
  
  Volume: 1397 Pages: 55-65
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Luminal Interaction of Phogrin with Carboxypeptidase E for Effective Targeting to Secretory Granules.2011
- Author(s)
  Saito, N., Takeuchi, T., Kawano, A., Hosaka, M., Hou, N., Torii, S.
- Journal Title
  
  Traffic
  
  Volume: 12 Pages: 499-506
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Silylation Enhancement of Photodynamic Activity of Tetraphenylporphyrin Derivative.2011
- Author(s)
  Horiuchi, H., Kameya, T., Hosaka, M., Yoshimura, K., Kyushin, S., Matsumoto, H., Okutsu, T., Takeuchi, T., Hiratsuka, H.
- Journal Title
  
  J. Photochem. Photobiol.
  
  Volume: 221 Pages: 98-104
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Cyclophilin C-associated protein regulation of microglia/macrophage functions via NFAT activation in focal cerebral ischemia2011
- Author(s)
  Yamaguchi R, Hosaka M, Torii S, Hou N, Imai H, Saito N, Yoshimoto Y, Takeuchi T
- Journal Title
  
  Brain Res
  
  Volume: 1397 Pages: 55-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300159
[Journal Article] Silylation Enhancement of Photodynamic Activity of Tetraphenylporphyrin Derivative2011
- Author(s)
  Horiuchi, H., Kameya, T., Hosaka, M., Yoshimura, K., Kyushin, S., Matsumoto, H., Okutsu, T., Takeuchi, T., Hiratsuka, H.
- Journal Title
  
  J. Photochem. Photobiol
  
  Volume: 221 Pages: 98-104
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Luminal Interaction of Phogrin with Carboxypeptidase E for Effective Targeting to Secretory Granules2011
- Author(s)
  Saito, N., Takeuchi, T., Kawano, A., Hosaka, M., Hou, N., Torii, S.
- Journal Title
  
  Traffic
  
  Volume: 12 Pages: 499-506
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Silylation Enhancement of Photodynamic Activity of Tetraphenylporphyrin Derivative.J.Photochem.Photobiol.2011
- Author(s)
  Horiuchi, H., Kameya, T., Hosaka, M., Yoshimura, K., Kyushin, S., Matsumoto, H., Okutsu, T., Takeuchi, T., Hiratsuka, H.
- Journal Title
  
  J.Photochem.Photobiol.
  
  Volume: 221 Issue: 1 Pages: 98-104
- DOI
  10.1016/j.jphotochem.2011.04.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570133, KAKENHI-PROJECT-23750145
[Journal Article] Development of Iridium(III) Complexes with High Cellular Uptake Efficiency.2011
- Author(s)
  Yoshihara, T., Ichikawa, K., Hosaka, M., Takeuchi, T., Tobita, S.
- Journal Title
  
  Photomedicine and Photobiology
  
  Volume: 33 Pages: 15-16
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Luminal interaction between phogrin and carboxypeptidase E assists their effective targeting into secretory granules2011
- Author(s)
  Saito N, Takeuchi T, Kawano A, Hosaka M, Hou N, Torii S
- Journal Title
  
  Traffic
  
  Volume: 12 Pages: 499-506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300159
[Journal Article] Secretogranin lll : a bridge between core homone aggregates and the secretory granule membrane.2010
- Author(s)
  Hosaka M, Watanabe T
- Journal Title
  
  Endocrine J
  
  Volume: 57 Pages: 275-286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Phosphorescent light-emitting iridium complexes serves as a hypoxia-sensing probe for tumor imaging in living animals.2010
- Author(s)
  Zhang S, Hosaka M, Yoshihara T, Negishi K, Iida Y, Tobita S, Takeuchi T
- Journal Title
  
  Cancer Research (In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300159
[Journal Article] (The first two authors contributed equally to this work.): Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic beta-Cells2010
- Author(s)
  Tsuchiya, M., Hosaka, M., Moriguchi, T., Zhang, S., Suda, M., Yokota-Hashimoto, H., Shinozuka, K., Takeuchi, T
- Journal Title
  
  Endocrinology
  
  Volume: 151 Pages: 4705-4716
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Phosphorescent light-emitting iridium complexes serves as a hypoxia-sensing probe for tumor imaging in living animals.2010
- Author(s)
  Zhang S, Hosaka M, Yoshihara T, Negishi K, lida Y, Tobita S, Takeuchi T
- Journal Title
  
  Cancer Research
  
  Volume: 70 Pages: 4490-4498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300159
[Journal Article] Cholesterol biosynthetic intermediates enhance regulated insulin secretion and secretory granule formation in pancreatic-cells2010
- Author(s)
  Tsuchiya M, Hosaka M, Moriguchi T, Zhang S-J, Suda M, Hashimoto-Yokota H, Shinozuka K, Takeuchi T
- Journal Title
  
  Endocrinology
  
  Volume: 151 Pages: 16-4705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300159
[Journal Article] Iridium complex, a phosphorescent light-emitting diode material2010
- Author(s)
  Zhang S, Hosaka M, Yoshihara T, Negishi K, Iida Y, Tobita S, Takeuchi T
- Journal Title
  
  serves as anovel tool for imaging hypoxic cancertissues Cancer Res
  
  Volume: 70 Pages: 4490-4498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300159
[Journal Article] Secretogranin III: a Bridge between Core Hormone Aggregates and the Secretory Granule Membrane2010
- Author(s)
  Hosaka M, Watanabe T
- Journal Title
  
  Endocr J
  
  Volume: 57 Issue: 4 Pages: 275-286
- DOI
  10.1507/endocrj.K10E-038
- NAID
  10029584142
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590185
[Journal Article] Phosphorescent Light-emtting lridium Complexes Serve as a Hypoxia-sensing Probe for Tumor lmaging in Living Animals.2010
- Author(s)
  Zhang, S., Hosaka, M., Yoshihara, T., Negishi, K., lida, Y., Tobita, S., Takeuchi, T
- Journal Title
  
  Cancer Research
  
  Volume: 70 Pages: 4490-4498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Phosphorescent Light-emitting Iridium Complexes Serve as a Hypoxia-sensing Probe for Tumor Imaging in Living Animals.2010
- Author(s)
  Zhang, S., Hosaka, M., Yoshihara, T., Negishi, K., Iida, Y., Tobita, S., Takeuchi, T. (The first three authors contributed equally to this work.)
- Journal Title
  
  Cancer Research
  
  Volume: 70 Pages: 4490-4498
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Secretograin lll : a bridge between core hormone aggregates and the secretory granule membrane2010
- Author(s)
  Hosaka M, Watanabe T
- Journal Title
  
  Endocrine J
  
  Volume: 57 Pages: 275-286
- Data Source
  KAKENHI-PROJECT-22590185
[Journal Article] Secretogranin III : a bridge between core hormone aggregates and the secretory granule membrane.2010
- Author(s)
  Hosaka M, Watanabe T
- Journal Title
  
  Endocrine J
  
  Volume: 57 Pages: 275-286
- NAID
  10029584142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] (The first three authors contributed equally to this work.): Phosphorescent Light-emitting Iridium Complexes Serve as a Hypoxia-sensing Probe for Tumor Imaging in Living Animals2010
- Author(s)
  Zhang, S., Hosaka, M., Yoshihara, T., Negishi, K., Iida, Y., Tobita, S., Takeuchi, T.
- Journal Title
  
  Cancer Research
  
  Volume: 70 Pages: 4490-4498
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic beta-Cells.2010
- Author(s)
  Tsuchiya, M., Hosaka, M., Moriguchi, T., Zhang, S., Suda, M., Yokota-Hashimoto, H., Shinozuka, K., Takeuchi, T
- Journal Title
  
  Endocrinology
  
  Volume: 151 Pages: 4705-4716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic beta-Cells.2010
- Author(s)
  Tsuchiya, M., Hosaka, M., Moriguchi, T., Zhang, S., Suda, M., Yokota-Hashimoto, H., Shinozuka, K., Takeuchi, T. (The first two authors contributed equally to this work.)
- Journal Title
  
  Endocrinology
  
  Volume: 151 Pages: 4705-4716
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Secretogranin III: a bridge between core hormone aggregates and the secretory granule membrane.2010
- Author(s)
  Hosaka, M., Watanabe, T.
- Journal Title
  
  Endocrine J.
  
  Volume: 57 Pages: 275-286
- NAID
  10029584142
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Secretogranin III: a bridge between core hormone aggregates and the secretory granule membrane2010
- Author(s)
  Hosaka M, Watanabe T
- Journal Title
  
  Endocrine J
  
  Volume: 57 Pages: 275-286
- NAID
  10029584142
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Secretogranin II Binds to Secretogranin III and Forms Secretory Granules with Orexin, Neuropeptide Y and Proopiomelanocortin.2009
- Author(s)
  Hotta, K., Hosaka, M., Tanabe, A., Takeuchi, T. (The first two authors contributed equally to this work.)
- Journal Title
  
  J. Endocrinol.
  
  Volume: 202 Pages: 13-14
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Cholesterol Analogs Labeled with Novel Silylated Fluorescent Compounds.2009
- Author(s)
  Moriguchi, T., Hosaka, M., Yosinari, A., Ozaki, A., Takeuchi, T., Shinozuka, K.
- Journal Title
  
  Chemistry Letters
  
  Volume: 38 Pages: 966-967
- NAID
  10025547099
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Development of photodetection method of trmor using phosphorescence of iridium(III) complexes.2009
- Author(s)
  Yoshihara T, Kasahara Y, Negishi K, Hosaka M, Takeuchi T, Tobita S
- Journal Title
  
  Photomedicine and Photobiology 31
  
  Pages: 13-14
- Data Source
  KAKENHI-PROJECT-21300159
[Journal Article] Development of photodetection method of tumor using phosphorescence of iridium(III)complexes2009
- Author(s)
  Yoshihara T, Karasawa Y, Negishi K, Fushiya M, Hosaka M, Takeuchi T, Tobita S
- Journal Title
  
  Photomedicine and Photobiology 31
  
  Pages: 13-14
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Cholesterol Analogs Labeled with Novel Silylated Fluorescent Compounds2009
- Author(s)
  Moriguchi T, Hosaka M, Yosinari A, Ozaki A, Takeuchi T, Shinozuka K
- Journal Title
  
  Chem Lett
  
  Volume: 38 Pages: 966-967
- NAID
  10025547099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300159
[Journal Article] Development of photodetection method of tumor using phosphorescence of iridium(III) complexes.2009
- Author(s)
  Yoshihara, T., Karasawa, Y., Negishi, K., Fushiya, M., Hosaka, M., Takeuchi, T., Tobita, S.
- Journal Title
  
  Photomedicine and Photobiology
  
  Volume: 31 Pages: 13-14
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Effects of a depot formulation of the GnRH agonist leuprorelin on the ultrastrucure of male rat pitultray gonadotropes2008
- Author(s)
  Kitahara, K. Sakai, Y., Hosaka, M. Hira, Y., Kakizaki, H., Watanabe, T.
- Journal Title
  
  Arch Histol Cytol 70
  
  Pages: 79-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] 内分泌細胞における分泌顆粒形成機構2008
- Author(s)
  渡部剛、阪井裕子、平義樹、暮地本宙己、穂坂正博
- Journal Title
  
  顕微鏡 43
  
  Pages: 29-34
- NAID
  10021151701
- Data Source
  KAKENHI-PROJECT-18590177
[Journal Article] Sorting mechanism of peptide hormones to secretory granules by the lead of cholesterol-binding protein, secretogranin III, in endocrine cells2008
- Author(s)
  Takeuchi T, and Hosaka, M.
- Journal Title
  
  Current Diabetes Rev 4
  
  Pages: 31-38
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] Sorting mechanism of peptide hormones to secretory granules by the lead of cholesterol-binding protein secretogranin III in endocrine cells2008
- Author(s)
  Takeuchi T, and Hosaka M.
- Journal Title
  
  Current Diabetes Rev 4
  
  Pages: 31-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] A subset of p23 localized on secretory granules in pancreatic beta-cells2007
- Author(s)
  Hosaka, M., Watanabe, T., Yamauchi, Y., Sakai, Y., Suda, M., Mizutani, S., Takeuchi, T., Isobe, T., Izumi, T.
- Journal Title
  
  J Histochem. Cytochem 55
  
  Pages: 235-245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] ホルモンが分泌穎粒へ選別されるメカニズム2007
- Author(s)
  穂坂正博
- Journal Title
  
  生化学(社団法人生化学) 79
  
  Pages: 166-170
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] Effects of adepot formulation of the GnRH agonist leuprorelin on the ultrastructure of male rat pituitary gonadotropes2007
- Author(s)
  Kitahara K, Sakai Y, Hosaka M, Hira Y,Kakizaki H, Watanabe T
- Journal Title
  
  Arch Histol Cytol 70
  
  Pages: 79-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590177
[Journal Article] A Subset of p23 Localized on Secretory Granules in Pancreatic β-cells.2007
- Author(s)
  Hosaka M, Watanabe T, Yamauchi Y, Sakai Y, Suda M, Mizutani S, Takeuchi T, Isobe T, Izumi T.
- Journal Title
  
  J Histochem Cytochem 55
  
  Pages: 235-245
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] A subset of p23 localized on secretory granules in pancreatic beta-cells.2007
- Author(s)
  Hosaka, M., Watanabe, T., Yamauchi, Y., Sakai, Y., Suda, M., Mizutani, S., Takeuchi, T., Isobe, T., Izumi, T.
- Journal Title
  
  J. Histochem. Cytochem. 55
  
  Pages: 235-245
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] ホルモンが分泌穎粒へ選別されるメカニズム2007
- Author(s)
  穂坂正博
- Journal Title
  
  化学(社団法人生化学 79
  
  Pages: 166-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] Molecular probes for sensing the cholesterol composition of subcellular organelle membranes.2006
- Author(s)
  Wang, R., Hosaka, M., Han, L., Yokota-Hashimoto, H., Suda, M., Mitsushims, D., Torii, S., Takeuchi, T.
- Journal Title
  
  Biochim. Biophys. Acta. 1761
  
  Pages: 1169-1181
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] Molecular probes for sensing the cholesterol composition of subcellular organelle membranes2006
- Author(s)
  Wang, R., Hosaka, M., Han, L., Yokota-Hashimoto, H., Suda, M., Mitsushims, D., Torii, S., Takeuchi, T.
- Journal Title
  
  Biochim. Biophys. Acta 1761
  
  Pages: 1169-1181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] Molecular probes for sensing the cholesterol composition of subcellular organelle membranes.2006
- Author(s)
  Wang R, Hosaka M, Han L, Yokota-Hashimoto H, Suda M, Mitsushima D, Torii S, Takeuchi T.
- Journal Title
  
  BBA-Mol Cell Biol Lipids 1761
  
  Pages: 1169-1181
- Data Source
  KAKENHI-PROJECT-18500235
[Journal Article] Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granule.2005
- Author(s)
  Hosaka M, Watanabe T, Sakai Y, Kato T, Takeuchi T.
- Journal Title
  
  J Cell Sci 118
  
  Pages: 4785-4795
- Data Source
  KAKENHI-PROJECT-16044206
[Journal Article] Immunocytochemical localization of secretograin III in the endocrine pancreas of male rats.2004
- Author(s)
  Sakai Y, Hosaka M, Yoshinaga A, Hira Y, Harumi T, Watanabe T.
- Journal Title
  
  Arch.Histol.Cytol. 67
  
  Pages: 57-64
- Data Source
  KAKENHI-PROJECT-16044206
[Journal Article] Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A.2004
- Author(s)
  Hosaka, M., Suda, M., Sakai, Y., Izumi, T, Watanabe, T., Takeuchi, T.
- Journal Title
  
  J.Biol.Chem. 30
  
  Pages: 3627-3634
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500205
[Journal Article] PTHrP induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-jun N-terminal kinase in pancreatic b-cells.2004
- Author(s)
  Zhang, B., Hosaka, M., Sawada, Y., Torii, S., Mizutani, S., Ogata, M., Izumi, T., Takeuchi, T.
- Journal Title
  
  Diabetes 52
  
  Pages: 2720-2730
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500205
[Journal Article] Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats.2004
- Author(s)
  Sakai, Y., Hosaka M., Yoshinaga, A., Hira, Y., Harumi, T., Watanabe, T.
- Journal Title
  
  Arch Histol Cytol. 67
  
  Pages: 57-64
- NAID
  10012846445
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500205
[Journal Article] Angiogenic enfothelium-specific nestin expression is enhanced by the first intron of the nestin gene.2004
- Author(s)
  Aihara M, Sugawara K, Torii S, Hosaka M, Kurihara H, Saito N
- Journal Title
  
  Laboratory Investigation 84
  
  Pages: 1581-1592
- Data Source
  KAKENHI-PROJECT-15500205
[Journal Article] Functional localization of proprotein -convertase furin and its substrate TGFb in EGF receptor-expressing gastric chief cells.2004
- Author(s)
  Fujisawa, T., Kamimura, H., Hosaka, M., Torii, S., Izumi, T., Kuwano, H., Takeuchi, T.
- Journal Title
  
  Growth Factors 22
  
  Pages: 51-59
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500205
[Journal Article] Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats.2004
- Author(s)
  Sakai, Y., Hosaka, M., Yoshinaga, A., Hira, Y., Harumi, T., Watanabe, T.
- Journal Title
  
  Arch Histol Cytol. 67
  
  Pages: 57-64
- NAID
  10012846445
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500205
[Journal Article] Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene.2004
- Author(s)
  Aihara M, Sugawara K, Torii S, Hosaka M, Kurihara H, Saito N.
- Journal Title
  
  Laboratory Investigation 84
  
  Pages: 1581-1592
- Data Source
  KAKENHI-PROJECT-16044206
[Journal Article] Angiogenic Endothelium-specific Nestin Expression is enhanced by the First Intron of the Nestin Gene.2004
- Author(s)
  Aihara, M., Sugawara, K., Torii, S., Hosaka.M., Kurihara, H., Saito, N., Takeuchi, T.
- Journal Title
  
  Lab.Invest. 84
  
  Pages: 1581-1592
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500205
[Journal Article] Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats.2004
- Author(s)
  Sakai Y, Hosaka M, Yoshinaga A, Hira Y, Harumi T, Watanabe T
- Journal Title
  
  Arch.Histol.Cytol. 67
  
  Pages: 57-64
- NAID
  10012846445
- Data Source
  KAKENHI-PROJECT-15500205
[Journal Article] Angiogenic Endothelium-specific Nestin Expression is enhanced by the First Intron of the Nestin Gene.2004
- Author(s)
  Aihara, M., Sugawara, K., Torii, S., Hosaka M, Kurihara, H., Saito, N., Takeuchi, T.
- Journal Title
  
  Lab.Invest. 84
  
  Pages: 1581-1592
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500205
[Journal Article] Functional localization of proprotein-convertase furin and its substrate TGFb in EGF receptor-expressing gastric chief cells.2004
- Author(s)
  Fujisawa, T., Kamimura, H., Hosaka, M., Torii, S., Izumi, T., Kuwano, H., Takeuchi, T.
- Journal Title
  
  Growth Factors 22
  
  Pages: 51-59
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500205
[Journal Article] A unique ball-shapeed Golgi apparatus in the rat pituitary ganadotrope : its functional implications in relation to the arrangement of microtuble network
- Author(s)
  Watanabe, T., Sakai, Y., Koga, D., Bochimoto, H., Hira, Y., Hosaka, M., Ushiki, T.
- Journal Title
  
  J.Histochem.Cytochem.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570133
[Journal Article] Sustained treatment with a GnRH agonist (leuprorelin) affects the ultrastructural characteristics of membranous organelles in male rat pituitary gonadotropes
- Author(s)
  Bochimoto H, Koga D, Sakai Y, Hira Y, Hosaka M, Ushiki T, Watanabe T
- Journal Title
  
  Arch Histol Cytol
  
  Volume: (in press)
- NAID
  130005087927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590185
[Journal Article] Phosphorescent Light-emitting Iridium Complexes Serve as a Hypoxia-sensing Probe for Tumor Imaging in Living Animals
- Author(s)
  Zhang S, Hosaka M, Yoshihara T, Negishi K, Iida Y, Tobita S, Takeuchi, T
- Journal Title
  
  Cancer Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Luminal Interaction of Phogrin with Carboxypeptidase E for Effective Targeting to Secretory Granules.
- Author(s)
  Saito, N., Takeuchi, T., Kawano, A., Hosaka, M., Hou, N., Torii, S.
- Journal Title
  
  Traffic
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages.
- Author(s)
  Yamaguchi, R., Hosaka, M., Torii, S., Hou, N., Saito, N., Yoshimoto, Y., Imai., H., Takeuchi, T.
- Journal Title
  
  Brain Res.
  
  Volume: 1397 Pages: 55-65
- Data Source
  KAKENHI-PROJECT-21200077
[Journal Article] Luminal Interaction of Phogrin with Carboxypeptidase E for Effective Taraetina to Secretory Granules.
- Author(s)
  Saito, N., Takeuchi, T., Kawano, A., Hosaka, M, Hou, N., Torii, S
- Journal Title
  
  Traffic
  
  Volume: Inpress
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570133
[Patent] 非アルコール性脂肪性肝炎（NASH）診断薬2016
- Inventor(s)
  穂坂正博，畠恵司，樋渡一之，佐々木玲，高橋純一郎
- Industrial Property Rights Holder
  穂坂正博，畠恵司，樋渡一之，佐々木玲，高橋純一郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-003717
- Filing Date
  2016-01-12
- Data Source
  KAKENHI-PROJECT-25440052
[Patent] 含ケイ素置換基を導入した化合物、並びにそれを含む一重項酸素発生剤及び癌治療薬2013
- Inventor(s)
  堀内宏明、穂坂正博、平塚浩士、竹内利行、久新荘一郎、石田真太郎
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2012-531819
- Filing Date
  2013-02-05
- Data Source
  KAKENHI-PROJECT-22570133
[Patent] 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法2013
- Inventor(s)
  吉原利忠、飛田成史、竹内利行、穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Filing Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-22570133
[Patent] 含ケイ素蛍光化合物および該化合物を用いた蛍光標識剤2012
- Inventor(s)
  篠塚和夫, 森口朋尚, 竹内利行, 穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Acquisition Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] 含ケイ素蛍光化合物および該化合物を用いた蛍光標識剤2012
- Inventor(s)
  篠塚和夫、森口朋尚、竹内利行、穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Filing Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-22570133
[Patent] 酸素濃度測定試薬および酸素濃度測定方法2012
- Inventor(s)
  飛田成史, 吉原利忠, 竹内利行, 穂坂正博
- Industrial Property Rights Holder
  群馬大学
- Acquisition Date
  2012-02-24
- Data Source
  KAKENHI-PROJECT-21200077
[Patent] 酸素濃度測定試薬および酸素濃度測定方法2012
- Inventor(s)
  飛田成史, 吉原利忠, 竹内利行, 穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Acquisition Date
  2012-02-24
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] 抗DNP抗体を用いたコレステロール結合体2011
- Inventor(s)
  竹内利行, 穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Acquisition Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] Novel compound and functional luminescent probe comprising the same2011
- Inventor(s)
  飛田成史, 吉原利忠, 竹内利行, 穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Filing Date
  2011
- Overseas
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] 含ケイ素置換基を導入した化合物、並びにそれを含む一重項酸素発生剤及び癌治療薬2011
- Inventor(s)
  堀内宏明, 穂坂正博, 平塚浩司, 竹内利行, 久新荘一郎, 石田真太郎
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Filing Date
  2011-09-02
- Overseas
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] 新規化合物およびそれを含む機能性プローブNovel compound and functional luminescent probe comprising same2010
- Inventor(s)
  飛田成史, 吉原利忠, 穂坂正博, 竹内利行
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Filing Date
  2010-04-22
- Overseas
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] 新規化合物およびそれを含む機能性プローブNovel compound and functional luminescent probe comprising same2010
- Inventor(s)
  飛田成史, 吉原利忠, 穂坂正博, 竹内利行
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Filing Date
  2010-04-22
- Overseas
- Data Source
  KAKENHI-PROJECT-22570133
[Patent] 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法2010
- Inventor(s)
  吉原利忠, 穂坂正博, 竹内利行, 飛田成史
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2010-005220
- Filing Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] 新規化合物およびそれを含む機能性プローブNovel compound and functional luminescent probe comprising same2010
- Inventor(s)
  飛田成史, 吉原利忠, 穂坂正博, 竹内利行
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Filing Date
  2010-04-22
- Overseas
- Data Source
  KAKENHI-PROJECT-21200077
[Patent] 新規化合物およびそれを含む機能性プローブ:Novel compound and functionalluminescent probe comprising same2010
- Inventor(s)
  飛田成史, 吉原利忠, 穂坂正博, 竹内利行
- Industrial Property Rights Holder
  群馬大学
- Filing Date
  2010-04-22
- Overseas
- Data Source
  KAKENHI-PROJECT-21200077
[Patent] Novel Compound and Functional Luminescent Probe Comprising the Same (新規化合物およびそれを含む機能性発光プローブ)2009
- Inventor(s)
  飛田成史,吉原利忠,穂坂正博,竹内利行
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Filing Date
  2009-10-16
- Overseas
- Data Source
  KAKENHI-PROJECT-22570133
[Patent] 新規錯体化合物、並びにそれを用いた酸素濃度測定試薬および癌の診断薬2009
- Inventor(s)
  飛田成史, 吉原利忠, 竹内利行, 穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2009-166878
- Filing Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] Novel Compound and Functional Luminescent Probe Comprising the Same (新規化合物およびそれを含む機能性発光プローブ)2009
- Inventor(s)
  飛田成史,吉原利忠,穂坂正博,竹内利行
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Filing Date
  2009-10-16
- Overseas
- Data Source
  KAKENHI-PROJECT-22570133
[Patent] コレステロール含有膜のコレステロール含量の測定方法2009
- Inventor(s)
  竹内利行, 穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Acquisition Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] Novel compound and functional luminescent probe comprising the same2009
- Inventor(s)
  飛田成史, 吉原利忠, 竹内利行, 穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Filing Date
  2009-10-16
- Overseas
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] 新規化合物およびそれを含む機能性発光プローブ2009
- Inventor(s)
  飛田成史,吉原利忠,穂坂正博,竹内利行
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2010-533937
- Filing Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-22570133
[Patent] 新規化合物およびそれを含む酸素濃度に依存して発光色が変化する機能性プローブ2009
- Inventor(s)
  飛田成史, 吉原利忠, 竹内利行, 穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2010-533937
- Filing Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-21300159
[Patent] 含ケイ素蛍光化合物および該化合物を用いた蛍光標識剤2007
- Inventor(s)
  篠塚和夫森口朋尚竹内利行穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2007-075414
- Filing Date
  2007-04-19
- Data Source
  KAKENHI-PROJECT-18500235
[Patent] 抗DNP抗体を用いたコレステロール結合体2007
- Inventor(s)
  竹内利行穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2007-214640
- Filing Date
  2007-08-21
- Data Source
  KAKENHI-PROJECT-18500235
[Patent] 「含ケイ素蛍光化合物および該化合物を用いた蛍光標識剤」2007
- Inventor(s)
  篠塚和夫、森口朋尚、竹内利行、穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2007-075414
- Filing Date
  2007-04-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Patent] 「新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法」2007
- Inventor(s)
  吉原利忠、飛田成史、竹内利行、穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2007-110515
- Filing Date
  2007-03-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Patent] 「抗DNP抗体を用いたコレステロール結合体」2007
- Inventor(s)
  竹内利行、穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2007-214640
- Filing Date
  2007-08-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Patent] 酸素濃度測定試薬および酸素濃度測定方法2007
- Inventor(s)
  吉原利忠飛田成史竹内利行穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2007-126518
- Filing Date
  2007-05-19
- Data Source
  KAKENHI-PROJECT-18500235
[Patent] 「新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法」2007
- Inventor(s)
  山田圭一、穂坂正博、吉原利忠、片貝良一、飛田成史、竹内利行
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2007-262203
- Filing Date
  2007-10-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Patent] 「酸素濃度測定試薬および酸素濃度測定方法」2007
- Inventor(s)
  吉原利忠、飛田成史、竹内利行、穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2007-126518
- Filing Date
  2007-05-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Patent] 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法2007
- Inventor(s)
  山田圭一穂坂正博吉原利忠片貝良一飛田成史竹内利行
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2007-262203
- Filing Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18500235
[Patent] 「含ケイ素蛍光化合物および該化合物を用いた蛍光標識剤」2006
- Inventor(s)
  篠塚和夫、森口朋尚、竹内利行、穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2006-276757
- Filing Date
  2006-10-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Patent] 「コレステロール結合剤およびコレステロール検出キット」2006
- Inventor(s)
  竹内利行、穂坂正博
- Industrial Property Rights Holder
  国立大学法人群馬大学
- Industrial Property Number
  2006-161408
- Filing Date
  2006-06-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] 分泌顆粒へのホルモン輸送機構が冗長性を持つ意義:生活習慣病の危険因子としてのグラニンタンパク質不全2024
- Author(s)
  穂坂正博、五味浩司、渡部剛
- Organizer
  先端モデル動物支援プラットフォーム成果発表会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03411
[Presentation] 分泌顆粒へのホルモン輸送機構が冗長性を持つ意義：生活習慣病の危険因子としてのグラニンタンパク質不全2024
- Author(s)
  穂坂正博、五味浩司、渡部剛
- Organizer
  先端モデル動物支援プラットフォーム成果発表会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06070
[Presentation] セクレトグラニンが制御する下垂体前葉ホルモンの分泌/産生2023
- Author(s)
  河田秋音、平島優花、五味浩司、渡部剛、穂坂正博
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H03411
[Presentation] インスリン分泌でセクレトグラニンIIが果たす役割を個体レベルで明らかにする2023
- Author(s)
  平島優花、河田秋音、五味浩司、渡部剛、穂坂正博
- Organizer
  第89回日本生化学会東北支部例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06070
[Presentation] インスリン分泌でセクレトグラニンが果たす役割2023
- Author(s)
  平島優花、河田秋音、五味浩司、渡部剛、穂坂正博
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06070
[Presentation] セクレトグラニンが制御する下垂体前葉ホルモンの分泌／産生2023
- Author(s)
  河田秋音、平島優花、五味浩司、渡部剛、穂坂正博
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06070
[Presentation] インスリン分泌でセクレトグラニンが果たす役割2023
- Author(s)
  平島優花、河田秋音、五味浩司、渡部剛、穂坂正博
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H03411
[Presentation] グラニンタンパク質が制御する下垂体前葉ホルモンの分泌/産生を明らかにする2023
- Author(s)
  河田秋音、平島優花、五味浩司、渡部剛、穂坂正博
- Organizer
  第89回日本生化学会東北支部例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06070
[Presentation] コルヒチン脳室内投与ラットの視床下部神経分泌細胞におけるグラニン蛋白発現部位の同定2022
- Author(s)
  森永涼介、甲賀大輔、穂坂正博、渡部剛
- Organizer
  日本解剖学会第68回東北・北海道連合支部学術集会
- Data Source
  KAKENHI-PROJECT-20H03411
[Presentation] The role of secretogranin III in the endocrine cells of the adrenal gland2022
- Author(s)
  岩﨑拓美、五味浩司、渡部剛、穂坂正博
- Organizer
  第95回日本生化学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06070
[Presentation] 内分泌細胞でペプチドホルモンがゴルジ体から分泌顆粒へ輸送される機構について2022
- Author(s)
  穂坂正博
- Organizer
  日本大学獣医学科
- Invited
- Data Source
  KAKENHI-PROJECT-21K06070
[Presentation] 視床下部下垂体系におけるグラニン蛋白の局在と機能的意義2022
- Author(s)
  森永涼介、甲賀大輔、穂坂正博、渡部剛
- Organizer
  日本解剖学会第127回総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-20H03411
[Presentation] 視床下部-下垂体系におけるグラニン蛋白の発現パターンの差異2021
- Author(s)
  森永涼介、甲賀大輔、穂坂正博、渡部剛
- Organizer
  日本解剖学会第67回東北・北海道連合支部学術集会
- Data Source
  KAKENHI-PROJECT-20H03411
[Presentation] 内分泌細胞の高コレステロール組成分泌顆粒膜に結合するタンパク質群の探索2021
- Author(s)
  安達美喜、渡部剛、穂坂正博
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06070
[Presentation] セクレトグラニンIII欠損マウスにおいて高脂肪/高糖質食負荷時に顕在化する耐糖能異常2021
- Author(s)
  渡部剛、甲賀大輔、森永涼介、穂坂正博
- Organizer
  第126回日本解剖学会全国学術集会/第98回日本生理学会大会合同大会
- Data Source
  KAKENHI-PROJECT-20H03411
[Presentation] 内分泌細胞の高コレステロール組成分泌顆粒膜に結合するタンパク質群を探索する2020
- Author(s)
  安達美喜、渡辺剛，穂坂正博
- Organizer
  日本生化学会東北支部第86回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-18K05443
[Presentation] ストレス負荷で顕在化するホルモン輸送不全の謎：生活習慣病の危険因子としてのグラニンタンパク質欠損2020
- Author(s)
  穂坂正博
- Organizer
  先端モデル動物支援プラットフォーム
- Invited
- Data Source
  KAKENHI-PROJECT-18K05443
[Presentation] Research for maturation of the secretory granule in endocrine cells2019
- Author(s)
  Tsuchiya A., Tsushima K., Hosaka M.
- Organizer
  第92回日本生化学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05443
[Presentation] 内分泌細胞でペプチドホルモンがゴルジ体から分泌顆粒へ輸送される機構について2019
- Author(s)
  穂坂正博
- Organizer
  研究セミナー（鳥取大学医学部）
- Invited
- Data Source
  KAKENHI-PROJECT-18K05443
[Presentation] Expression of secretogranin III in a living animal Expression of secretogranin III in a living animal2019
- Author(s)
  Hinata A., Yasui T., Gomi H., Hosaka M.
- Organizer
  第92回日本生化学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05443
[Presentation] 分泌顆粒形成におけるグラニンタンパク質の役割（セクレトグラニンIIIが糖代謝に与える影響）2018
- Author(s)
  穂坂正博
- Organizer
  宮崎大学医学部（中里クレスト班）
- Data Source
  KAKENHI-PROJECT-18K05443
[Presentation] 非アルコール性脂肪性肝炎（NASH）をイリジウム錯体の発光で探索する2017
- Author(s)
  2.栢森藍佳、畠恵司、樋渡一之、佐々木玲、高橋純一郎、鳥居征司、吉原利忠、飛田成史、穂坂正博
- Organizer
  第90回生化学会
- Data Source
  KAKENHI-PROJECT-16K13103
[Presentation] 非アルコール性脂肪性肝炎（NASH）を光で探す2016
- Author(s)
  栢森　藍佳、畠　恵司、樋渡　一之、佐々木　玲、高橋　純一郎、鳥居　征司、吉原　利忠、飛田　成史、穂坂　正博
- Organizer
  第82回生化学会東北支部会
- Place of Presentation
  弘前大学（青森県弘前市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-16K13103
[Presentation] 非アルコール性脂肪性肝炎（NASH）をイリジウム錯体で探す2016
- Author(s)
  栢森　藍佳、畠　恵司、樋渡　一之、佐々木　玲、高橋　純一郎、鳥居　征司、吉原　利忠、飛田　成史、穂坂　正博
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K13103
[Presentation] セクレトグラニンIIIが膵島インスリン生合成と分泌で果たす役割について2015
- Author(s)
  前田佳紀、工藤咲希、暮地本宙己、村田知里、鳥居征司、渡部剛、穂坂正博
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] 脳下垂体内分泌細胞の低酸素環境におけるホルモン分泌の解析2015
- Author(s)
  佐藤瑛理、前田佳紀、暮地本宙己、渡部剛、穂坂正博
- Organizer
  第81回日本生化学会東北支部例会
- Place of Presentation
  仙台
- Year and Date
  2015-05-09
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] セクレトグラニンIIIが生体のインスリン生合成と分泌で果たす役割2015
- Author(s)
  前田佳紀、工藤咲希、暮地本宙己、村田知里、鳥居征司、渡部剛、穂坂正博
- Organizer
  第81回日本生化学会東北支部例会
- Place of Presentation
  仙台
- Year and Date
  2015-05-09
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] 脳下垂体内分泌細胞の低酸素環境におけるACTH分泌について2015
- Author(s)
  佐藤瑛理、前田佳紀、暮地本宙己、渡部剛、穂坂正博
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] 生体の低酸素病態をイメージングするプローブの開発：高輝度改良体BTPDMの検証2014
- Author(s)
  寺田幹、吉原利忠、飛田成史、穂坂正博
- Organizer
  第80回生化学会東北支部例会
- Place of Presentation
  秋田
- Year and Date
  2014-05-10
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] 内分泌細胞の分泌顆粒に局在するセクレトグラニンIIIの役割2014
- Author(s)
  前田佳紀、暮地本宙己、村田知里、鳥居征司、渡部剛、穂坂正博
- Organizer
  第80回生化学会東北支部例会
- Place of Presentation
  秋田
- Year and Date
  2014-05-10
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] 分泌顆粒形成でセクレトグラニンIIIが果たす役割2013
- Author(s)
  穂坂正博、暮地本宙己、渡部剛
- Organizer
  第28回日本下垂体研究会
- Place of Presentation
  花巻温泉（ホテル千秋閣：岩手）
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] Multiple sorting systems for the secretory granules ensure the regulated secretion of peptide hormones in endocrine cells2013
- Author(s)
  Masahiro Hosaka, Hiroki Bochimoto, Tsuyoshi Watanabe
- Organizer
  第65回日本細胞生物学会
- Place of Presentation
  ウインクあいち（愛知県産業労働センター；名古屋））
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] GnRH レセプター刺激を受けたラット下垂体前葉性腺刺激ホルモン産生細胞に出現する粗面小胞体の変化2013
- Author(s)
  暮地本宙己、甲賀大輔、穂坂正博、牛木辰男、渡部剛
- Organizer
  第118回日本解剖学会全国学術集会
- Place of Presentation
  高松
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-22590185
[Presentation] イリジウム錯体を発光プローブとする低酸素病態のイメージング：高輝度改良体BTPDMの検証2013
- Author(s)
  寺田幹、吉原利忠、飛田成史、穂坂正博
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] 様々な分泌刺激に対する細胞内膜系小器官の応答の解析: 下垂体前葉性腺刺激ホルモン産生細胞をモデルとして2012
- Author(s)
  暮地本宙己、甲賀大輔、穂坂正博、牛木辰男、渡部剛
- Organizer
  第117回日本解剖学会全国学術集会・シンポジウム「細胞外シグナルと下垂体細胞の発達、機能発現への形態学的アプローチ」
- Place of Presentation
  甲府
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-22590185
[Presentation] 様々な分泌刺激に対する細胞内膜系小器官の応答の解析:下垂体前葉性腺刺激ホルモン産生細胞をモデルとして2012
- Author(s)
  暮地本宙己、甲賀大輔、穂坂正博、牛木辰男、渡部剛
- Organizer
  第117回日本解剖学会総会
- Place of Presentation
  甲府
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] コルヒチン投与による性腺刺激ホルモン産生細胞(LH/FSH 産生細胞)のゴルジ装置の微細構造変化2012
- Author(s)
  渡部剛、暮地本宙己、穂坂正博
- Organizer
  第58回日本解剖学会東北・北海道連合支部学術集会
- Place of Presentation
  山形
- Year and Date
  2012-09-22
- Data Source
  KAKENHI-PROJECT-22590185
[Presentation] 低酸素病態イメージングプローブの開発:イリジウム錯体による腫瘍のイメージング2012
- Author(s)
  穂坂正博、寺田幹、吉原利忠、竹内利行、飛田成史
- Organizer
  第78回日本生化学会東北支部例会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] Iridium complex probes for monitoring of cellular oxygen levels and imaging of hypoxic tissues2012
- Author(s)
  Tobita S, Yoshihara T, Kobayashi A, ichikawa K, Hosaka M, Takeuchi T
- Organizer
  BiOS SPIE Photonics West
- Place of Presentation
  San Francisco, USA
- Year and Date
  2012-01-24
- Data Source
  KAKENHI-PROJECT-21300159
[Presentation] 様々な分泌刺激に対する細胞内膜系小器官の応答の解析:下垂体前葉性腺刺激ホルモン産生細胞をモデルとして2012
- Author(s)
  暮地本宙己、甲賀大輔、穂坂正博、牛木辰男、渡部剛
- Organizer
  第117回日本解剖学会総会
- Place of Presentation
  甲府市
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] イリジウム錯体で低酸素病態をイメージングする2012
- Author(s)
  寺田幹、吉原利忠、飛田成史、穂坂正博
- Organizer
  第21回秋田応用生命科学研究会
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] Iridiumcomplex probes for monitoring of cellular oxygen levels and imaging of hypoxic tissues2012
- Author(s)
  Tobita, S., Yoshihara, T., Kobayashi, A., Ichikawa, K., Hosaka, M., Takeuchi, T
- Organizer
  SPIE
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] Iridiumcomplex probes for monitoring of cellular oxygen levels and imaging of hypoxic tissues2012
- Author(s)
  Tobita, S., Yoshihara, T., Kobayashi, A., Ichikawa, K., Hosaka, M., Takeuchi, T
- Organizer
  SPIE
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] 内分泌細胞の分泌顆粒形成におけるグラニンタンパク質の役割2012
- Author(s)
  穂坂正博, 孫夢, 鳥居征司, 竹内利行, 暮地本宙己, 渡部剛
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] 様々な分泌刺激に対する細胞内膜系小器官の応答の解析:下垂体前葉性腺刺激ホルモン産生細胞をモデルとして：2012
- Author(s)
  暮地本宙己, 甲賀大輔, 穂坂正博, 牛木辰男, 渡部剛
- Organizer
  第１１７回日本解剖学会総会
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 内分泌細胞の分泌顆粒形成におけるグラニンタンパク質の役割2012
- Author(s)
  穂坂正博, 孫夢, 鳥居征司, 竹内利行, 暮地本宙己, 渡部剛
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] Iridiumcomplex probes for monitoring of cellular oxygen levels and imaging of hypoxictissues2012
- Author(s)
  Tobita, S., Yoshihara, T., Kobayashi, A., Ichikawa, K., Hosaka, M., Takeuchi, T
- Organizer
  SPIE
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] Iridium complex probes for monitoring of cellular oxygen levels and imaging of hypoxic tissues2012
- Author(s)
  Tobita S, Yoshihara T, Kobayashi A, ichikawa K, Hosaka M, Takeuchi T
- Organizer
  BiOS SPIE Photonics West
- Place of Presentation
  San Francisco
- Year and Date
  2012-01-24
- Data Source
  KAKENHI-PROJECT-21300159
[Presentation] 内分泌細胞の分泌顆粒形成におけるグラニンタンパク質の役割2012
- Author(s)
  穂坂正博、孫夢、暮地本宙己、渡部剛
- Organizer
  第20回秋田応用生命科学研究会
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] Iridiumcomplex probes for monitoring of cellular oxygen levels and imaging of hypoxictissues2012
- Author(s)
  Tobita, S., Yoshihara, T., Kobayashi, A., Ichikawa, K., Hosaka, M., Takeuchi,T
- Organizer
  SPIE
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] 高い酸素応答性を有する近赤外発光イリジウム錯体の開発と光物理特性2011
- Author(s)
  八木橋美樹, 吉原利忠, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  2011年光化学討論会
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 神経内分泌細胞の分泌顆粒形成機序2011
- Author(s)
  穂坂正博
- Organizer
  第18回秋田応用生命科学研究会
- Place of Presentation
  秋田市
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] 神経内分泌細胞の分泌顆粒形成機序2011
- Author(s)
  穂坂正博
- Organizer
  第18回秋田応用生命科学研究会
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] がんの光イメージングのためのりん光プローブ分子の開発2011
- Author(s)
  吉原利忠, 市川和貴, 八木橋美樹, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  第６回日本分子イメージング学会学術大会
- Year and Date
  2011-05-22
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] イリジウム錯体のりん光を用いた低酸素がん腫瘍イメージング:配位子の構造が細胞内動態に及ぼす影響2011
- Author(s)
  市川和貴, 吉原利忠, 小林敦, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  第5回分子科学討論会
- Place of Presentation
  札幌市
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] Developments of Hypoxia-Sensing Probes with High Cellular Uptake Efficiency2011
- Author(s)
  Yoshihara, T., Ichikawa, K., Hosaka, M., Takeuchi, T., Tobita, S.
- Organizer
  The First International Symposium on Element Innovation
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] In vivoりん光寿命計測による低酸素組織内酸素レベルの可視化2011
- Author(s)
  飛田成史, 小林敦, 吉原利忠, 穂坂正博, 竹内利行
- Organizer
  日本分子イメージング学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-21300159
[Presentation] 生体内低酸素領域を識別するためのイリジウム錯体の開発および生体内発光特性2011
- Author(s)
  吉原利忠, 市川和貴, 大堀優佳, 小林敦, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  第5回分子科学討論会
- Place of Presentation
  札幌市
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] がんの光イメージングのためのりん光プローブ分子の開発2011
- Author(s)
  吉原利忠、市川和貴、八木橋美樹、穂坂正博、竹内利行、飛田成史
- Organizer
  第6回日本分子イメージング学会学術大会
- Place of Presentation
  神戸市
- Year and Date
  2011-05-22
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] イリジウム錯体のりん光寿命測定によるin vivo酸素濃度計測2011
- Author(s)
  小林敦, 吉原利忠, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  第５回分子科学討論会
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 近赤外りん光を示すイリジウム錯体を用いた低酸素がん腫瘍イメージング2011
- Author(s)
  大堀優佳, 吉原利忠, 小林敦, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  第5回分子科学討論会
- Place of Presentation
  札幌市
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 高い酸素応答性を有する近赤外発光イリジウム錯体の開発と光物理特性2011
- Author(s)
  八木橋美樹、吉原利忠、穂坂正博, 竹内利行、飛田成史
- Organizer
  2011年光化学討論会
- Place of Presentation
  宮崎市
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] AtT-20 細胞におけるセクレトグラニンIII (SgIII) の発現抑制はトランスゴルジネットワーク(TGN) の空胞化と調節性分泌の部分障害を誘起する2011
- Author(s)
  渡部剛、暮地本宙己、穂坂正博
- Organizer
  第57回日本解剖学会東北・北海道連合支部学術集会
- Place of Presentation
  盛岡
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22590185
[Presentation] イリジウム錯体のりん光寿命測定によるin vivo酸素濃度計測2011
- Author(s)
  小林敦, 吉原利忠, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  第5回分子科学討論会
- Place of Presentation
  札幌市
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 近赤外りん光を示すイリジウム錯体を用いた低酸素がん腫瘍イメージング2011
- Author(s)
  大堀優佳, 吉原利忠, 小林敦, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  第５回分子科学討論会
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 生体内低酸素領域を識別するためのイリジウム錯体の開発および生体内発光特性2011
- Author(s)
  吉原利忠, 市川和貴, 大堀優佳, 小林敦, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  第５回分子科学討論会
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 高い細胞膜透過性を示すイリジウム錯体の開発およびin vivo光イメージング2011
- Author(s)
  吉原利忠、市川和貴、穂坂正博、竹内利行、飛田成史
- Organizer
  第33回日本光医学・光生物学会
- Place of Presentation
  大阪市
- Year and Date
  2011-07-23
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] イリジウム錯体のりん光を用いた低酸素がん腫瘍イメージング:配位子の構造が細胞内動態に及ぼす影響2011
- Author(s)
  市川和貴, 吉原利忠, 小林敦, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  第５回分子科学討論会
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] アミノクマリン誘導体を蛍光団とする蛍光性コレステロールの開発と光物理特性2011
- Author(s)
  追川竜介、吉原利忠、村瀬秋子、穂坂正博、飛田成史
- Organizer
  2011年光化学討論会
- Place of Presentation
  宮崎市
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 「内分泌細胞の分泌顆粒形成におけるグラニン蛋白の役割」第88回日本生理学会大会/第116回日本解剖学会全国学術集会・合同大会2011
- Author(s)
  渡部剛、暮地本宙己、穂坂正博
- Organizer
  シンポジウム「内分泌細胞における新たな分泌制御機構と分泌現象」
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590185
[Presentation] アミノクマリン誘導体を蛍光団とする蛍光性コレステロールの開発と光物理特性2011
- Author(s)
  追川竜介, 吉原利忠, 村瀬秋子, 穂坂正博, 飛田成史
- Organizer
  2011年光化学討論会
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues.2010
- Author(s)
  Masahiro Hosaka
- Organizer
  2010 World Molecular Imaging Congress
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] Phosphorescent light-emitting iridium complexes serves as a hypoxia-sensing probe for tumor imaging living animals2010
- Author(s)
  Takeuchi T, Zhang S, Negishi K, Yoshihara T, Hosaka M, Tobita S.
- Organizer
  BiOS SPIE Photonics West
- Place of Presentation
  San Francisco, U.S.A.
- Year and Date
  2010-01-25
- Data Source
  KAKENHI-PROJECT-21300159
[Presentation] Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues2010
- Author(s)
  Masahiro Hosaka
- Organizer
  2010 World Molecular Imaging Congress
- Place of Presentation
  京都
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues2010
- Author(s)
  Masahiro Hosaka
- Organizer
  2010 World Molecular Imaging Congress
- Place of Presentation
  Kyoto
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] Phosphorescent light-emitting iridium complexes serves as a hypoxiasensingprobe for tumor imaging in living animals2010
- Author(s)
  Takeuchi T, Zhang S, Negishi K, Yoshihara T, Hosaka M, Tobita S
- Organizer
  BiOS SPIE Photonics West
- Place of Presentation
  San Francisco, USA
- Year and Date
  2010-01-25
- Data Source
  KAKENHI-PROJECT-21300159
[Presentation] lridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues2010
- Author(s)
  Masahiro Hosaka
- Organizer
  2010 World Molecular lmaging Congress
- Place of Presentation
  京都
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] 低酸素環境感知プローブイリジウム錯体による腫瘍イメージング2009
- Author(s)
  穂坂正博、吉原利忠、張少娟、飯田靖彦、遠藤啓吾、飛田成史、竹内利行
- Organizer
  日本生化学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] イリジウム錯体のリン光を利用した癌の光検出法の開発2009
- Author(s)
  吉原利忠, 根岸一也, 伏屋昌則, 穂坂正博, 張少娟, 竹内利行, 飛田成史
- Organizer
  日本光医学会・光生物学会
- Place of Presentation
  大阪梅田スカイビル
- Year and Date
  2009-07-24
- Data Source
  KAKENHI-PROJECT-21300159
[Presentation] Sorting mechanism of regulated secretory proteins by Secretogranin III2009
- Author(s)
  穂坂正博
- Organizer
  15th International Symposia on Chromaffin Cell Biology
- Place of Presentation
  Merida, MEXICO
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 癌のin vivoりん光イメージングを指向したイリジウム錯体の改良2009
- Author(s)
  吉原利忠, 根岸一也, 伏屋昌則, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  日本分子イメージング学会
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 癌の in vivo りん光イメージングを指向したイリジウム錯体の改良2009
- Author(s)
  吉原利忠、根岸一也、伏屋昌則、穂坂正博、竹内利行、飛田成史
- Organizer
  日本分子イメージング学会
- Place of Presentation
  学術総合センター
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 低酸素環境感知プローブイリジウム錯体による腫瘍イメージング2009
- Author(s)
  穂坂正博, 吉原利忠, 張少娟, 飯田靖彦, 遠藤啓吾, 飛田成史, 竹内利行
- Organizer
  日本生化学会
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] イリジウム錯体の燐光を利用した癌の光検出法の開発2009
- Author(s)
  吉原利忠, 唐澤靖幸, 根岸一也, 伏屋昌則, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  日本光医学会・光生物学会
- Year and Date
  2009-07-24
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] イリジウム錯休の燐光を利用した癌の光検出法の開発2009
- Author(s)
  吉原利忠, 唐澤靖幸, 根岸一也, 伏屋昌則, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  日本光医学会・光生物学会
- Place of Presentation
  梅田スカイビル
- Year and Date
  2009-07-24
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] Sorting mechanism of regulated secretory proteins by Secretogranin III2009
- Author(s)
  Masahiro Hosaka
- Organizer
  15th International Symposia on Chromaffin Cell Biology
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21200077
[Presentation] 内分泌細胞における分泌顆粒形成とそれに係わるグラニン蛋白と脂質ラフトの役割分泌現象と生体膜、そしてその可視化2008
- Author(s)
  渡部剛、阪井裕子、穂坂正博
- Organizer
  第81回日本内分泌学会学術総会シンポジウム
- Place of Presentation
  青森
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-18590177
[Presentation] A large form of Secretogranin III functions as a sorting receptor for chromogranin A in PC12 cells2007
- Author(s)
  穂坂正博, 韓路, 渡部剛, 竹内利行
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] A large form of Secretogranin III functions as a sorting receptor for chromogranin A in PC12 cells2007
- Author(s)
  穂坂正博, 韓路, 渡部剛, 竹内利行
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] A large form of Secretogranin III functions as a sorting receptor for chromoeranin A in PC12 cells2007
- Author(s)
  Masahiro Hosaka, Lu Han, Tsuyoshi Watanabe, Toshiyuki Takeuchi
- Organizer
  Biochemistry and Molecular Biology 2007
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] The sorting mechanism to Secretory Granules: Emerging Concepts with Secretogranin III2006
- Author(s)
  穂坂正博
- Organizer
  Gordon Research Conferences
- Place of Presentation
  USA
- Year and Date
  2006-07-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] 分泌顆粒へのペプチドホルモン選別輸送機構2006
- Author(s)
  穂坂正博
- Organizer
  第21回日本下垂体研究会
- Place of Presentation
  静岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] The sorting mechanism to Secretory Granules2006
- Author(s)
  Masahiro Hosaka
- Organizer
  24th JES Summer Seminar on Endocrinology & Metabolism
- Place of Presentation
  Kanagawa
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] The sorting mechanism to Secretory Granules: Emerging Concents with Secretogranin III2006
- Author(s)
  Masahiro Hosaka
- Organizer
  National Institute of Health
- Place of Presentation
  USA
- Year and Date
  2006-07-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] 神経・内分泌細胞における分泌蛋白の動線の再考-ゴルジ装置の極性が示すもの-平義樹ゴルジ装置と物質輸送のイメージング2006
- Author(s)
  渡部剛、穂坂正博、阪井裕子、平義樹
- Organizer
  NPO法人綜合画像研究支援・第3回可視化技術ワークショップ
- Place of Presentation
  東京
- Year and Date
  2006-11-11
- Data Source
  KAKENHI-PROJECT-18590177
[Presentation] 神経内分泌細胞の分泌顆粒形成機構解析2006
- Author(s)
  穂坂正博
- Organizer
  第24回内分泌代謝学サマーセミナー
- Place of Presentation
  神奈川
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] The sorting mechanism to Secretory Granules2006
- Author(s)
  Masahiro Hosaka
- Organizer
  The Japan society for pituitary research
- Place of Presentation
  Shizuoka
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] The sorting mechanism to Secretory Granules: Emerging Concepts with Secretogranin III2006
- Author(s)
  Masahiro Hosaka
- Organizer
  National Institute of Health (USA)
- Place of Presentation
  Washington
- Year and Date
  2006-07-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] The sorting mechanism to Secretory Granules: Emerging Concepts with Secretogranin III2006
- Author(s)
  Masahiro Hosaka
- Organizer
  Gordon Research Conferences
- Place of Presentation
  Boston
- Year and Date
  2006-07-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500235
[Presentation] ；イリジウム錯体を発光プローブとする低酸素病態のイメージング：改良体の組織浸潤性と組織集積および細胞内分布について
- Author(s)
  寺田幹、吉原利忠、鳥居征司、飛田成史、穂坂正博
- Organizer
  第87回生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] Golgi Apparatus Structures and Function: Sorting Mechanisms of Prohormones from the Trans-Golgi Network to Secretory Granules: Concepts with Granin-Family Protein
- Author(s)
  Masahiro Hosaka
- Organizer
  Gordon Research Conferences
- Place of Presentation
  New London, U.S.A.
- Year and Date
  2014-07-20 – 2014-07-25
- Invited
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] 低酸素病態イメージングプローブの開発：イリジウム錯体による腫瘍のイメージング
- Author(s)
  穂坂正博、寺田幹、吉原利忠、竹内利行、飛田成史
- Organizer
  第78回日本生化学会東北支部例会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] 内分泌細胞の分泌顆粒形成におけるグラニンタンパク質の役割
- Author(s)
  穂坂正博、暮地本宙己、渡部剛
- Organizer
  第7９回日本生化学会東北支部会例会
- Place of Presentation
  東北大学（仙台）
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] 神経内分泌細胞の分泌顆粒に局在するセクレトグラニンIIIの生体で果たす役割
- Author(s)
  前田佳紀、暮地本宙己、村田知里、鳥居征司、渡部剛、穂坂正博
- Organizer
  第87回生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] イリジウム錯体で低酸素病態をイメージングする
- Author(s)
  寺田幹、吉原利忠、飛田成史、穂坂正博
- Organizer
  第21回秋田応用生命科学研究会
- Place of Presentation
  秋田市
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] GnRHアゴニスト持続投与によりラットLH/FSH 産生細胞で生じるLH 分泌・産生機能の変化
- Author(s)
  暮地本宙己、穂坂正博、板東良雄、甲賀大輔、平義樹、牛木辰男、渡部剛
- Organizer
  日本解剖学会第60回東北・北海道連合支部学術集会
- Place of Presentation
  福島
- Year and Date
  2014-09-06 – 2014-09-07
- Data Source
  KAKENHI-PROJECT-25440052
[Presentation] 内分泌細胞の分泌顆粒形成におけるグラニンタンパク質の役割
- Author(s)
  穂坂正博、孫夢、暮地本宙己、渡部剛
- Organizer
  第20回秋田応用生命科学研究会
- Place of Presentation
  秋田市
- Data Source
  KAKENHI-PROJECT-22570133
[Presentation] 高い細胞膜透過性を示すイリジウム錯体の開発およびin vivo光イメージング
- Author(s)
  吉原利忠, 市川和貴, 穂坂正博, 竹内利行, 飛田成史
- Organizer
  第33回日本光医学・光生物学会
- Data Source
  KAKENHI-PROJECT-21200077

1. WATANABE Tsuyoshi (80220903)

# of Collaborated Projects: 7 results

# of Collaborated Products: 41 results
2. TOBITA Seiji (30164007)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
3. YAMADA Keiichi (70323334)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Bochimoto Hiroki (60632841)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
5. SAKAI Yuko (40041826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. YOSHIHARA Toshitada (10375561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 40 results
7. IIDA Yasuhiko (60252425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. TAKEUCHI Toshiyuki (00109977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
9. 甲賀大輔 (30467071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 鳥居征司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 五味浩司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 岩下淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosaka Masahiro 穂坂 正博

HOSAKA Masahiro 穂坂 正博

Research Projects

Research Products

Co-Researchers

セクレトグラニンに依存しない分泌顆粒へのホルモン選別輸送機構を探索するPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Sorting mechanism of processing enzymes to the secretory granules.Principal Investigator

Principal Investigator

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Review Section

Research Institution

Physiological significance of the granin protein family in the endocrine function, revealed by analyzing the phenotypes of newly established Sg2- and Sg3-deficient mice.

Principal Investigator

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Review Section

Research Institution

Oxygen response in neuro-endocrine cells.Principal Investigator

Principal Investigator

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Review Section

Research Institution

non-alcoholic steatohepatitis imaging with iridium cpmplexesPrincipal Investigator

Principal Investigator

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Research Category

Research Field

Research Institution

Diversity in the global organization of the Golgi apparatus in differentiated secretory cells.

Principal Investigator

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Research Institution

Study for protein binding to the cholesterol-rich secretory granule membrane in neuroendocrine cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

The cholesterol metabolism of neuroendocrine cells and crosstalk of the hormone secretionPrincipal Investigator

Principal Investigator

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Research Institution

Characteristics in the overall organization and dynamics of the Golgi apparatus in the anterior pituitary endocrine cells.

Principal Investigator

Project Period (FY)

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Research Institution

Phosphorescent Light-emitting lridium Complexes Serve as a Hypoxia-sensing Probe for Tumor Imaging in Living Animals.Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Research and development of hypoxia-detecting luminescent probe iridium complex and its application to endoscopic imaging probes

Principal Investigator

Project Period (FY)

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Research Institution

Effects of LHRH analogues on the ultrastructure of male rat pituitary gonadotropes

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

The formation mechanisms of secretory granules and synaptic-like micro-vesicles by the lead of cholesterol in endocrine cells.Principal Investigator

Principal Investigator

Project Period (FY)

Hosaka Masahiro 穂坂正博

HOSAKA Masahiro 穂坂正博

[Book] 第一線の科学者が語る生活習慣病研究の最前線―メタボ・老化・がん研究からiPS細胞まで2012

[Book] 第一線の科学者が語る生活習慣病研究の最前線-メタボ・老化・がん研究から iPS細胞まで