Kanda Takeshi 神田武志

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KANDA Takeshi 神田武志

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Researcher Number	80317114
Other IDs
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 島根大学, 学術研究院医学・看護学系, 教授 2017 – 2022: 慶應義塾大学, 医学部(信濃町), 講師 2018: 慶應義塾大学, 腎臓内分泌代謝内科, 講師 2016: 慶應義塾大学, 保健管理センター(日吉), 講師 2013 – 2015: 慶應義塾大学, 保健管理センター, 講師 2005: 慶應大, 医学部, 助手 2002 – 2005: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Endocrinology / Basic Section 54040:Metabolism and endocrinology-related / Basic Section 53040:Nephrology-related / Metabolomics / Kidney internal medicine Except Principal Investigator Basic Section 53040:Nephrology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Kidney internal medicine / Circulatory organs internal medicine
Keywords	Principal Investigator 内皮細胞 / 肥満 / インスリン抵抗性 / Rhoキナーゼ / 褐色脂肪 / 褐色脂肪組織 / ＮＡＤ代謝産物 / 心血管疾患 / NAD / NAD代謝 … More / 動脈硬化 / 慢性腎臓病 / 脂質吸収 / 内分泌学 / 血管内皮細胞 / グレリン / レプチン / 高血圧 / p27 / 細胞増殖 / 腎障害 … More Except Principal Investigator NAD代謝 / 慢性腎臓病 / atRA / eNOS / DDAH / ADMA / 肥満関連腎症 / スタチン / ライソゾーム / p62 / Rhoキナーゼ / Rho / mTOR / オートファジー / エピゲノム変化 / 代謝腎臓病 / DNA損傷修復 / ニコチン酸代謝 / DNA損傷 / エピゲノム / 臨床 / シグナル伝達 / 薬理学 / 糖尿病 / 内科 / ＮＡＤ代謝 / NNMT / 心腎連関 / 腎線維化 / インスリン抵抗性 / 筋萎縮 / 無菌マウス / サルコペニア / 腎性インスリン抵抗性症候群 / 腸内細菌 / グレリン / NAD / SGLT2 / 臓器連関 / MKD / coronary endothelial dysfunction / chronic kidney disease / ATRA / 慢性腎不全 / 冠動脈内皮機能障害 / 慢性腎障害 Less

Autophagy impairment in obesity induced renal injuries
- Principal Investigator
  
  徳山博文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokyo Dental College
血管内皮細胞による褐色／ベージュ脂肪細胞の制御機構の解明Principal Investigator
- Principal Investigator
  
  神田武志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Shimane University
Spiral progression of DNA damage repair, epigenetic alterations and metabolic changes in metabolic kidney diseases
- Principal Investigator
  
  ITOH Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Keio University
The role of NAD metabolites in progression of arteriosclerosis in chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  KANDA TAKESHI
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Shimane University
  Keio University
The significant role of the kidney as a central organ for metabolic organ interrelationship
- Principal Investigator
  
  Itoh Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
the role of endothelial cells on adipocyte metabolismPrincipal Investigator
- Principal Investigator
  
  Kanda Takeshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Keio University
The role of endothelial leptin receptor in lifestyle-related diseases.Principal Investigator
- Principal Investigator
  
  KANDA Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Keio University
メタボリックシンドロームの代謝・循環異常のターゲットとしてのRhoキナーゼの役割Principal Investigator
- Principal Investigator
  
  神田武志
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Keio University
The investigation of inducing factors of cardiovascular events in early stage of chronic kidney disease
- Principal Investigator
  
  HAYASHI Koichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University
病態腎におけるRhoおよびRhoキナーゼ作用の分子メカニズムの検討Principal Investigator
- Principal Investigator
  
  神田武志
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2004

All Journal Article Presentation

[Journal Article] Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by inhibiting monocyte/macrophage TNF-α expression2023
- Author(s)
  Yoichi Oshima, Shu Wakino, Takeshi Kanda, Takaya Tajima, Tomoaki Itoh, Kiyotaka Uchiyama, Keiko Yoshimoto, Jumpei Sasabe, Masato Yasui, Hiroshi Itoh
- Journal Title
  
  Sci Rep
  
  Volume: 13 Issue: 1 Pages: 3331-3331
- DOI
  10.1038/s41598-023-30056-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08527, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20H00535
[Journal Article] The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease2022
- Author(s)
  Takahashi R, Kanda T, Komatsu M, Itoh T, Minakuchi H, Urai H, Kuroita T, Shigaki S, Tsukamoto T, Higuchi N, Ikeda M, Yamanaka R, Yoshimura N, Ono T, Yukioka H, Hasegawa K, Tokuyama H, Wakino S, Itoh H.
- Journal Title
  
  Sci Rep
  
  Volume: 12(1) Issue: 1 Pages: 6398-6399
- DOI
  10.1038/s41598-022-10476-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-22K08354, KAKENHI-PROJECT-21K18270
[Journal Article] Proximal-tubule molecular relay from early Protein diaphanous homolog 1 to late Rho-associated protein kinase 1 regulates kidney function in obesity-induced kidney damage2022
- Author(s)
  Ida-Naitoh Makiko、Tokuyama Hirobumi、Futatsugi Koji、Yasuda Marie、Adachi Keika、Kanda Takeshi、Tanabe Yoshiyuki、Wakino Shu、Itoh Hiroshi
- Journal Title
  
  Kidney International
  
  Volume: 102 Issue: 4 Pages: 798-814
- DOI
  10.1016/j.kint.2022.05.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20H00535
[Journal Article] Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy.2021
- Author(s)
  Yasuda I, Hasegawa K, Sakamaki Y, Muraoka H, Kawaguchi T, Kusahana E, Ono T, Kanda T, Tokuyama H, Wakino S, Itoh H.
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 11 Issue: 6 Pages: 1355-1370
- DOI
  10.1681/asn.2020081188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08218, KAKENHI-PROJECT-19K08732, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20H00535
[Journal Article] Low birth weight trends: possible impacts on the prevalences of hypertension and chronic kidney disease2020
- Author(s)
  Kanda Takeshi、Murai-Takeda Ayano、Kawabe Hiroshi、Itoh Hiroshi
- Journal Title
  
  Hypertension Research
  
  Volume: 43 Issue: 9 Pages: 859-868
- DOI
  10.1038/s41440-020-0451-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00535
[Journal Article] The effect of aldosterone and aldosterone blockade on the progression of chronic kidney disease: a randomized placebo-controlled clinical trial2020
- Author(s)
  Minakuchi Hitoshi、Wakino Shu、Urai Hidenori、Kurokochi Arata、Hasegawa Kazuhiro、Kanda Takeshi、Tokuyama Hirobumi、Itoh Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1
- DOI
  10.1038/s41598-020-73638-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00535
[Journal Article] Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy.2019
- Author(s)
  Muraoka H, Hasegawa K, Sakamaki Y, Minakuchi H, Kawaguchi T, Yasuda I, Kanda T, Tokuyama H, Wakino S, Itoh H.
- Journal Title
  
  Cell Rep.
  
  Volume: 27(1) Issue: 1 Pages: 199-212
- DOI
  10.1016/j.celrep.2019.03.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08218, KAKENHI-PROJECT-17H01562, KAKENHI-PROJECT-17H06270
[Journal Article] β-hydroxybutyrate attenuates renal ischemia-reperfusion injury through its anti-pyroptotic effects.2019
- Author(s)
  Tajima T, Yoshifuji A, Matsui A, Itoh T, Uchiyama K, Kanda T, Tokuyama H, Wakino S, Itoh H.
- Journal Title
  
  Kidney Int.
  
  Volume: 95 Issue: 5 Pages: 1120-1137
- DOI
  10.1016/j.kint.2018.11.034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01562, KAKENHI-PROJECT-18K08218, KAKENHI-PROJECT-17H06270
[Journal Article] Rho/Rho kinase as a molecular target for insulin resistance and hypertension2004
- Author(s)
  Takeshi kanda, et al.
- Journal Title
  
  Annual Meeting of the American Heart Association 2004, New Orleans 110
- Data Source
  KAKENHI-PROJECT-16790512
[Presentation] NAD+ Metabolite, 2-Py Has a Potent Anti-Fibrotic and Anti-Inflammatory Activity in the Mouse Unilaterally Ureter-Obstructed Kidney2019
- Author(s)
  Yoshimura N, Yamada K, Ono T, Notoya M, Sakamoto S, Yukioka H, Takahashi R, Kanda T, Wakino S, Itoh H
- Organizer
  American Society of Nephrology, Kidney Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01562
[Presentation] グレリンは血管内皮グレリン受容体を介して白色脂肪組織での脂質の取り込みを増加させ体重増加に寄与する2019
- Author(s)
  浦井秀徳、神田武志、小松素明、黒河内新、高橋利奈、長谷川一宏、徳山博文、脇野修、伊藤裕
- Organizer
  日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-16K09812
[Presentation] 腎機能障害進展におけるNAD代謝産物の意義2019
- Author(s)
  高橋利奈, 神田武志, 水口斉, 浦井秀徳, 黒河内新, 紫垣修
- Organizer
  日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-17H01562
[Presentation] 腎機能障害進行におけるNAD代謝産物の変動2018
- Author(s)
  北濱利奈, 神田武志, 水口斉, 浦井秀徳, 黒河内新, 長谷川一宏, 徳山博文, 脇野修, 伊藤裕
- Organizer
  日本心血管内分泌学会
- Data Source
  KAKENHI-PROJECT-17H01562
[Presentation] グレリン、レプチンは血管内皮細胞を介して白色脂肪組織での脂質の取り込みを調節する2018
- Author(s)
  神田武志、脇野修、伊藤裕
- Organizer
  第22回日本心血管内分泌代謝学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09812
[Presentation] NNMT活性化はNAD+代謝経路を調節することにより非アルコール性脂肪肝炎の進展に寄与する2018
- Author(s)
  神田武志, 小松素明, 浦井秀徳, 黒河内新, 北濱利奈, 脇野修, 伊藤裕
- Organizer
  日本心血管内分泌学会
- Data Source
  KAKENHI-PROJECT-17H01562
[Presentation] 慢性腎臓病におけるNAD代謝産物の意義2018
- Author(s)
  北濱利奈, 神田武志, 水口斉, 浦井秀徳, 黒河内新, 長谷川一宏, 徳山博文, 脇野修, 伊藤裕
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-17H01562
[Presentation] グレリン、レプチンは血管内皮細胞を介して白色脂肪組織での脂質の取り込みを調節する2018
- Author(s)
  神田武志
- Organizer
  日本心血管内分泌代謝学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09812
[Presentation] NNMT活性化はNAD+およびメチオニン代謝経路を調節することによってNAFLD/NASHの悪化に寄与する2017
- Author(s)
  神田武志, 小松素明, 浦井秀徳, 黒河内新, 北濱利奈, 脇野修, 伊藤裕
- Organizer
  日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-17H01562
[Presentation] 血管内皮グレリン受容体は白色脂肪組織での脂質の取り込みを制御する2017
- Author(s)
  浦井秀徳, 神田武志, 小松素明, 長谷川一宏, 徳山博文, 脇野修, 伊藤裕
- Organizer
  日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H01562
[Presentation] 血管内皮グレリン受容体は血圧と代謝応答を制御する2016
- Author(s)
  浦井秀徳，神田武志，小松素明、長谷川一宏，徳山博文，脇野修，伊藤裕
- Organizer
  第20回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  東京コンベンションホール(東京)
- Year and Date
  2016-12-16
- Data Source
  KAKENHI-PROJECT-16K09812
[Presentation] 血管内皮レプチン受容体の脂質吸収における役割2015
- Author(s)
  浦井秀徳，神田武志，林香、河邉博史、脇野修，伊藤裕
- Organizer
  第19回　日本心血管内分泌代謝学会学術総会
- Place of Presentation
  神戸国際会議場（神戸市）
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-25461396

1. WAKINO Shu (50265823)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
2. ITOH Hiroshi (40252457)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
3. 徳山博文 (50276250)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. 長谷川一宏 (30424162)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. KOMATSU Motoaki (70528687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HAYASHI Koichi (80164937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 林香 (60445294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOSHIMOTO Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kanda Takeshi 神田 武志

KANDA Takeshi 神田 武志

Research Projects

Research Products

Co-Researchers

Autophagy impairment in obesity induced renal injuries

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血管内皮細胞による褐色／ベージュ脂肪細胞の制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Spiral progression of DNA damage repair, epigenetic alterations and metabolic changes in metabolic kidney diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of NAD metabolites in progression of arteriosclerosis in chronic kidney diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The significant role of the kidney as a central organ for metabolic organ interrelationship

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

the role of endothelial cells on adipocyte metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of endothelial leptin receptor in lifestyle-related diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

メタボリックシンドロームの代謝・循環異常のターゲットとしてのRhoキナーゼの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The investigation of inducing factors of cardiovascular events in early stage of chronic kidney disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

病態腎におけるRhoおよびRhoキナーゼ作用の分子メカニズムの検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by inhibiting monocyte/macrophage TNF-α expression2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proximal-tubule molecular relay from early Protein diaphanous homolog 1 to late Rho-associated protein kinase 1 regulates kidney function in obesity-induced kidney damage2022

Author(s)

Journal Title

DOI

Data Source

Kanda Takeshi 神田武志

KANDA Takeshi 神田武志