TOMISUGI Yoshikazu 富杉佳計

Researcher Number	80322311
Affiliation (based on the past Project Information) *help	2008: 大阪大学, 大学院薬学研究科, 助教 2007: 大阪大学, 大学院・薬学研究科, 助教 2007: Osaka University, Graduate School of Pharmaceutical Sciences, Assistant Professor 2006: 大阪大学, 大学院薬学研究科, 助手 2003 – 2004: 熊本大学, 大学院・医学薬学研究部, 助手 2001 – 2002: 熊本大学, 薬学部, 助手
Review Section/Research Field	Except Principal Investigator Physical pharmacy / Physical pharmacy / Drug development chemistry
Keywords	Except Principal Investigator Drug Metabolism / Resonance Raman Spectroscopy / 薬物代謝 / 共鳴ラマン分光 / シトクロムP450 / Single Nucleotide Polymorphism / Cvtochrome P450 / 一塩基多型 / Substrate Specificity / Binding Constant … More / Equilibrium Dialysis / Cytochrome P450 / 平衡透析 / 基質特異性 / 結合定数 / 平衡誘析 / Heme Protein / Transcription Factor / Resonance Ramen Spectroscopy / Sensor Protein / Gas Molecules / シグナル伝達 / ガスセンサー / ヘムタンパク質 / 転写因子 / 共鳴ラマンスペクトル / センサータンパク質 / ガス分子 / 有機化学 / 生物物理 / 薬学 / インシリコ創薬 / 分子認識 / ポルフィリン / 四重鎖 / 核酸 / テロメラーゼ / テロメア Less

Predicition and verification for the structures and thermodynamic properties of telomeric DNA quadruplex/porphyrin complexes
- Principal Investigator
  
  ISHIKAWA Yoshinobu
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Shizuoka
  Kumamoto University
A Comprehensive Study on the Effect of Human Genetic Polymorphism on the Drug Metabolizing, Properties of CYP
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
A Comprehensive Study on the Effects of Genetic Polymorphism on the Drug Metabolizing Activity of Human CYP
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Studies on the Signal Transduction Mechanism by Gas Sensor Proteins
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University

All 2008 2007 2006 2004 2003

All Journal Article Presentation

[Journal Article] Molecular modeling of Anti-parallel G-quadruplex DNA/TMPyP Complexes2006
- Author(s)
  Yoshinobu Ishikawa, Yoshikazu Tomisugi, Tadayuki Uno
- Journal Title
  
  Nucleic Acids Symp.Ser. 50
  
  Pages: 331-332
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular modeling of Anti-parallel G-quadruplex DNA/TMPyP Complexes2006
- Author(s)
  Ishikawa Y, Tomisugi Y, Uno T
- Journal Title
  
  Nucleic Acids Symp. Ser 50
  
  Pages: 331-332
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] The C-Helix in CooA Rolls upon CO Binding to Ferrous Heme2004
- Author(s)
  Taku Yamashita, Yohei Hoashi, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 47320-47325
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Roles of Heme Axial Ligands in the Regulation of CO Binding to CooA2004
- Author(s)
  Taku Yamashita, Yohei Hoashi, Kimiko Watanabe, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 21394-21400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Residues in the Distal Heme Pocket of Neuroglobin : Implications for the Multiple Ligand Binding Steps2004
- Author(s)
  Tadayuki Uno, Daisuke Ryu, Hiroko Tsutsumi, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Anthony J.Wilkinson, Hideaki Sato, Takashi Hayashi
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 5886-5893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Inversion of Axial Coordination in Myoglobin to Create a "Proximal" Ligand Binding Pocket2003
- Author(s)
  Tadayuki Uno, Rikiharu Sakamoto, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Anthony J.Wilkinson
- Journal Title
  
  Biochemistry 42
  
  Pages: 10191-10199
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Presentation] インドールアミン2,3- ジオキシゲナーゼ(IDO)のヘム周辺環境と触媒機構2008
- Author(s)
  宇野公之、英杏子、牛田真衣、松浦明美、中山智香子、石川吉伸、富杉佳計、青山浩
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヘモグロビン四量体の会合安定化に関わるアミノ酸残基2008
- Author(s)
  宇野公之、瀧川総太郎、石丸武史、清田浩平、甲斐俊哉、石川吉伸、富杉佳計、青山浩
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP2C19における一塩基多型と代謝活性の相関2008
- Author(s)
  佐々木隆一、Sayed M. S. Ali、小山由希子、石川吉伸、富杉佳計、青山浩、宇野公之
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] The Heme Environment of Human Indoleamine 2,3-Dioxygenase2008
- Author(s)
  宇野公之、英杏子、牛田真衣、松浦明美、中山智香子、石川吉伸、富杉佳計、青山浩
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP2C9の薬物結合性及び選択性を決定する残基の評価2008
- Author(s)
  香川雄輔、佐々木隆一、渡辺亮介、石川吉伸、富杉佳計、青山浩、宇野公之
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Amino Acid Residues Responsible for the Stabilization of Hemoglobin Tetramer2008
- Author(s)
  宇野公之、瀧川総太郎、石丸武史、清田浩平、甲斐俊哉、石川吉伸、富杉佳計、青山浩
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP1A2の薬物結合性と代謝活性 ~一塩基多型が及ぼす影響~2007
- Author(s)
  宇野公之、辻本景英、江川真文、村田晋一、永井英次、石川吉伸、富杉佳計、前田初男
- Organizer
  日本薬学会127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP2C9の一塩基多型と薬物代謝活性との相関2007
- Author(s)
  宇野公之、香川雄輔、渡辺亮介、繁富輝明、植田哲嗣、富杉佳計、石川吉伸、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都テルサ
- Year and Date
  2007-06-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390013
[Presentation] ヒト薬物代謝酵素CYP2C9の一塩基多型と薬物代謝活性との相関2007
- Author(s)
  宇野公之、香川雄輔、渡辺亮介、繁富輝明、植田哲嗣、富杉佳計、石川吉伸、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] 薬物代謝酵素CYP2C19の基質認識と一塩基多型の影響2007
- Author(s)
  宇野公之、佐々木隆一、Sayed M.S. Ali、小山由希子、石川吉伸、富杉佳計、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP1A2の薬物結合性と代謝活性に対する一塩基多型の影響2007
- Author(s)
  宇野公之、辻本景英、江川真文、村田晋一、永井英次、石川吉伸、富杉佳計、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Correlations between SNPs and Drug Petabolizing Properties of Human CYPs2007
- Author(s)
  Tadayuki, Uno, Yusuke, Kagawa, Ryosuke, Watanabe, Teruaki, Shigetomi, Noritsugu, Ueda, Yoshikazu, Tomisugi, Yoshinobu, Ishikawa, Hatsuo, Maeda
- Organizer
  17th Symposium on the Reactions of Metals
- Place of Presentation
  Kyoto Tersa
- Year and Date
  2007-06-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390013
[Presentation] NO運搬タンパク質ニトロフォリン4の配位子結合に対する酸性残基の役割2007
- Author(s)
  宇野公之、大場伸紘、森山友美子、石川吉伸、富杉佳計、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] NO運搬タンパク質ニトロフォリン4(NP4)の外来性配位子結合機構の解明2007
- Author(s)
  宇野公之、大場伸紘、森山友美子、石川吉伸、富杉佳計、前田初男
- Organizer
  日本薬学会127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Molecular Modeling of Anti-parallel G-quadruplex DNA/TMPyP complexes2006
- Author(s)
  石川吉伸、富杉佳計、宇野公之
- Organizer
  第33回核酸化学シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2006-11-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Roles of Cysteine Residues in the Gas Binding to Human Neuroglobin2006
- Author(s)
  Tadayuki Uno, Leila Hafsi, Hiroko Tsutsumi, Daisuke Ryu, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Hatsuo Maeda
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Exogenous Ligand Binding Mechanism of Cytoglobin2006
- Author(s)
  Tadayuki Uno, Kaori Kukino, Hatsuo Maeda, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Norifumi Kawada, Katsutoshi Yoshizato, Hitomi Sawai, and Yoshitsugu Shiro
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Resonance Raman Studies of CYP2C19 and Its Complexes with Substrates2006
- Author(s)
  Sayed M. S. Ali, Yukiko Oyama, Yoshinobu Ishikawa, Yoshikazu Tomisugi, Hatsuo Maeda, and Tadayuki Uno
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] サイトグロビン及びニューログロビンの外来性配位子結合機構2006
- Author(s)
  宇野公之、久木野香里、堤紘子、龍大輔、前田初男、富杉佳計、石川吉伸、河田則文、吉里勝利、澤井仁美、城宜嗣
- Organizer
  第16回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  東京
- Year and Date
  2006-06-01
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Over-expression of Recombinant Human Hemoglobin2006
- Author(s)
  Tadayuki Uno, Takefumi Ishimaru, Sohtaro Takigawa, Yohei Hoashi, Toshiya Kai, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Hatsuo Maeda
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] 組換え型ヒトヘモグロビン大量発現系の構築2006
- Author(s)
  宇野公之、石丸武史、帆足洋平、甲斐俊哉、前田初男、富杉佳計、石川吉伸
- Organizer
  第16回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  東京
- Year and Date
  2006-06-01
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] CYP1A2の一塩基多型による薬物結合性と代謝活性の変化2006
- Author(s)
  宇野公之、江川真文、村田晋一、辻本景英、前田初男、富杉佳計、石川吉伸
- Organizer
  第16回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  東京
- Year and Date
  2006-06-01
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Substrate Binding and Metabolizing Properties of Indoleamine 2,3-Dioxygenase2006
- Author(s)
  Tadayuki Uno, Mai Ushida, Akemi Matsuura, Chikako Nakayama, Tomoko Hosokawa, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Hatsuo Maeda
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098

1. ISHIKAWA Yoshinobu (00305004)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
2. UNO Tadayuki (00183020)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. 前田初男 (00229311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

TOMISUGI Yoshikazu 富杉 佳計

Research Projects

Research Products

Co-Researchers

Predicition and verification for the structures and thermodynamic properties of telomeric DNA quadruplex/porphyrin complexes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Comprehensive Study on the Effect of Human Genetic Polymorphism on the Drug Metabolizing, Properties of CYP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Comprehensive Study on the Effects of Genetic Polymorphism on the Drug Metabolizing Activity of Human CYP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the Signal Transduction Mechanism by Gas Sensor Proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Molecular modeling of Anti-parallel G-quadruplex DNA/TMPyP Complexes2006

Author(s)

Journal Title

Data Source

[Journal Article] Molecular modeling of Anti-parallel G-quadruplex DNA/TMPyP Complexes2006

Author(s)

Journal Title

Data Source

[Journal Article] The C-Helix in CooA Rolls upon CO Binding to Ferrous Heme2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Roles of Heme Axial Ligands in the Regulation of CO Binding to CooA2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Residues in the Distal Heme Pocket of Neuroglobin : Implications for the Multiple Ligand Binding Steps2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Inversion of Axial Coordination in Myoglobin to Create a "Proximal" Ligand Binding Pocket2003

Author(s)

Journal Title

Description

Data Source

[Presentation] インドールアミン2,3- ジオキシゲナーゼ(IDO)のヘム周辺環境と触媒機構2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ヘモグロビン四量体の会合安定化に関わるアミノ酸残基2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ヒト薬物代謝酵素CYP2C19における一塩基多型と代謝活性の相関2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The Heme Environment of Human Indoleamine 2,3-Dioxygenase2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

TOMISUGI Yoshikazu 富杉佳計