TAKEDA SOUICHI 武田壮一

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TAKEDA Soichi 武田壮一

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Researcher Number	80332279
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
Affiliation (based on the past Project Information) *help	2015 – 2017: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2012 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 室長 2013: 独立行政法人国立循環器病研究センター研究所, 室長 2011: 国立循環器病研究センター, 心臓生理機能部, 室長 2010 – 2011: 独立行政法人国立循環器病研究センター, 心臓生理機能部, 室長 … More 2010: 独立行政法人国立循環器病研究センター, 分子病態部, 室長 2010: 独立行政法人国立循環器病研究センター, 心臓整理機能部, 室長 2007 – 2009: National Cardiovascular Center Research Institute, 心臓生理部, 室長 2008: National Cardiovascular Center Research Institute, 心臓生理部, 室長 2008: 循環器病センター, 研究員 2005 – 2006: 国立循環器病センター(研究所), 心臓生理部, 室長 2004: 国立循環器病センター研究所, 心臓生理部, 室長 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Biological Sciences / Biophysics Except Principal Investigator Structural biochemistry / General physiology / Living organism molecular science / Cell biology / Biological Sciences
Keywords	Principal Investigator X線結晶構造解析 / タンパク質間相互作用 / プロテアーゼ / 蛇毒 / 構造生物学 / ADAM / 蛋白質複合体 / マルチドメイン構造 / 基質認識機構 / トロンビン産生 … More / タンパク質立体構造 / タンパク質分解 / エクトドメインシェディング / メタロプロテアーゼ / ADAMTS / エクトドメイン・シェディング / 前駆体 / 活性制御 / 基質認識 / モジュラータンパク / 複合体 / マルチドメイン / 細胞間シグナリング / トロンビン / シグナル伝達 / 血液凝固 / 血栓 / ディスインテグリン / シグナリング / ドメイン構造 / モジュラータンパク質 / 細胞外シグナリング / 血液凝固因子 / X線 / 細胞外シグナル伝達 / タンパク結晶学 / EFハンド / タンパク質結晶学 / EF-handタンパク質 / タンパク質結晶 / 放射光 / EFハンドタンパク質 / トロポミオシン / カルシウム / 筋収縮調節 / トロポニン … More Except Principal Investigator 結晶構造 / ADAMTS13 / VWF / 結晶解析 / プロテインS / ずり応力 / 酵素動力学 / von Willebrand因子 / トランスポーター / 細胞内イオン制御 / 創薬 / 生理活性脂質 / トランスポータ / 筋収縮制御 / X線散乱 / トロボニン / 中性子散乱 / X線結晶解 / 筋収縮調節 / 心筋症 / 量子ビーム / 中性子非弾性散乱 / X線小角散乱 / トロポニン / 遺伝性心筋症 / 活性発現の分子機構 / BARドメイン / 生体分子 / ナノバイオ / タンパク質構造 / チロシンキナーゼ / バードメイン / 生体膜 / エクソサイト / P475S遺伝子多型 / 分子認識及び相互作用 / プロテアーゼ / 血小板凝集 / 組み換え体 / 血栓性血小板減少性紫斑病 / 立体構造解析 / プロラアーゼ / 血小板血栓 Less

Structural basis of substrate recognition and regulation by ADAM/ADAMTS family proteinasesPrincipal Investigator
- Principal Investigator
  
  TAKEDA Soichi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
止血血栓形成に関わる複合体プロテアーゼの構造生物学的研究Principal Investigator
- Principal Investigator
  
  武田壮一
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
高分子量プロテアーゼを介した細胞外シグナリングの構造生物学的研究Principal Investigator
- Principal Investigator
  
  武田壮一
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
Molecular mechanism for regulaiton of ion transporter via lipid signaling and its structural basis
- Principal Investigator
  
  WAKABAYASHI Shigeo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Cardiovascular Center Research Institute
Crystal structure analysis for the pathogenesis of thrombosis
- Principal Investigator
  
  AKIYAMA Masashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Structural study for understanding the molecular mechanism of ectodomain shedding by ADAM family proteinasesPrincipal Investigator
- Principal Investigator
  
  TAKEDA Soichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Protein pathology of cardiomyopathy-related mutants of troponin
- Principal Investigator
  
  FUJIWARA Satoru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Japan Atomic Energy Agency
ADAMTS13の基質認識・切断に対する細胞外環境の効果
- Principal Investigator
  
  宮田敏行
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.
- Principal Investigator
  
  AKIYAMA Masashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Crystal structure and regulation of Fer
- Principal Investigator
  
  MASUDA Michitaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  National Cardiovascular Center Research Institute
Structural and functional analysis of ADAM family proteinsPrincipal Investigator
- Principal Investigator
  
  TAKEDA Soichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
ADAMファミリー関連タンパク質の立体構造と作用機構の解明Principal Investigator
- Principal Investigator
  
  武田壮一
- Project Period (FY)
  2007 – 2008
- Research Institution
  National Cardiovascular Center Research Institute
トロポニン・トロポミオシン複合体のX線結晶構造解析Principal Investigator
- Principal Investigator
  
  武田壮一
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  National Cardiovascular Center Research Institute

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] “Structure-function relationship of the modular domains of the P-III class snake venom metalloproteinases (SVMPs) (Book chapter)” In Handbook of Toxinology, Venom Genomics and Proteomics (Gopalakrishnakone P. (ed.)), SpringerReference2014
- Author(s)
  Soichi Takeda
- Total Pages
  22
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26440040
[Book] Russellysin (Book chapter)"In The 3^<rd> edition of Handbook of Proteolytic Enzymes (Rawlings, N. and Salvesen, G. (ed.))2013
- Author(s)
  Takeda S.
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-23570156
[Book] “Russellysin (Book chapter)” In The 3rd edition of Handbook of Proteolytic Enzymes (Rawlings, N. and Salvesen, G. (ed.))2013
- Author(s)
  Soichi Takeda
- Total Pages
  4094
- Publisher
  Elsevier
- Data Source
  KAKENHI-PUBLICLY-23121536
[Book] “Russellysin (Book chapter)” In The 3rd edition of Handbook of Proteolytic Enzymes (Rawlings, N. and Salvesen, G. (ed.))2013
- Author(s)
  Takeda S
- Total Pages
  3
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-23570156
[Book] Russellysin (Book chapter)” In The 3rd edition of Handbook of Proteolytic Enzymes (Rawlings, N. and Salvesen, G. (ed.))2013
- Author(s)
  Takeda S
- Total Pages
  4094
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-23570156
[Book] 輸送体結合蛋白質の同定と複合体の構造解析 " トランスポートソームの世界編:金井好克, 竹島浩, 森泰生, 久保義弘"2011
- Author(s)
  若林繁夫, 武田壮一, 久光隆
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-23390046
[Book] Handbook of Metalloproteins (VAP1: snake venom homolog of mammalian ADAMs) (book chapter, p.1-15) (DOI:10.1002/0470028637.met234)2008
- Author(s)
  Takeda S
- Total Pages
  15
- Publisher
  John Wiley & Sons, Inc.
- DOI
  10.1002/0470028637.met234
- Data Source
  KAKENHI-PROJECT-19370047, KAKENHI-PROJECT-80332279
[Book] "Structure-function relationship of the modular domains of the P-III class snake venom metalloproteinases (SVMPs) (Book chapter)"In Handbook of Toxinology, Venom Genomics and Proteomics (Gopalakrishnakone P. (ed.))
- Author(s)
  Takeda S.
- Publisher
  SpringerReference, Springer
- Data Source
  KAKENHI-PROJECT-23570156
[Journal Article] ADAM and ADAMTS family proteins and snake venom proteinases: A structural overview2016
- Author(s)
  Soichi Takeda
- Journal Title
  
  Toxins
  
  Volume: 8 Pages: 1-35
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440040
[Journal Article] ADAM/ADAMTSファミリープロテアーゼの構造と機能2013
- Author(s)
  武田壮一
- Journal Title
  
  臨床検査
  
  Volume: 57(5) Pages: 535-540
- Data Source
  KAKENHI-PROJECT-23570156
[Journal Article] Crystal structure and enzymatic activity of an ADAMTS-13 mutant with the East Asian-specific P475S polymorphism2013
- Author(s)
  Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 11 Pages: 1399-1406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] 東アジア人特有のP475S変異を持ADAMTS13の立体構造と機能解析2013
- Author(s)
  秋山正志、武田壮一、宮田敏行
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 24 Pages: 613-618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] 東アジア人特有のP475S変異を持つADAMTS13の立体構造と機能解析2013
- Author(s)
  秋山正志, 武田壮一, 宮田敏行
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 24(6) Pages: 613-618
- NAID
  130003393326
- Data Source
  KAKENHI-PROJECT-23570156
[Journal Article] 東アジア人特有のP475S変異を持つADAMTS13の立体構造と機能解析2013
- Author(s)
  秋山正志、武田壮一、宮田敏行
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 24 Pages: 613-618
- NAID
  130003393326
- Data Source
  KAKENHI-PROJECT-23570156
[Journal Article] ADAM/ADAMTSファミリープロテアーゼの構造と機能2013
- Author(s)
  武田壮一
- Journal Title
  
  臨床検査
  
  Volume: 57 Pages: 535-540
- Data Source
  KAKENHI-PUBLICLY-23121536
[Journal Article] Crystal structure and enzymatic activity of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism.2013
- Author(s)
  Masashi Akiyama, Daisuke Nakayama, Soichi Takeda, Koichi Kokame, Junichi Takagi, and Toshiyuki Miyata.
- Journal Title
  
  J. Thromb. Haemost.
  
  Volume: (In press) Issue: 7 Pages: 1399-1406
- DOI
  10.1111/jth.12279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23570155, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060
[Journal Article] Crystal structure of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism2013
- Author(s)
  Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T.
- Journal Title
  
  J. Thromb. Haemost.
  
  Volume: 11 Pages: 1399-1406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570156
[Journal Article] Snake venom metalloproteinases : structure, function and relevance to the mammalian ADAM/ADAMTS family proteins (Review article)2012
- Author(s)
  Takeda S, Takeya H, Iwanaga S.
- Journal Title
  
  Biochim Biophys Acta Proteins and Proteomics
  
  Volume: 1824 Pages: 164-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570156
[Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction.2012
- Author(s)
  Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, and Mitsuhiko Sugimoto.
- Journal Title
  
  Thromb. Haemost.
  
  Volume: 108 Issue: 12 Pages: 1236-1238
- DOI
  10.1160/th12-09-0674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-22790923, KAKENHI-PROJECT-23570155, KAKENHI-PROJECT-23659494, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-24592744
[Journal Article] Snake venom metalloproteinases : structure, function and relevance to the mammalian ADAM/ADAMTS family proteins2012
- Author(s)
  Takeda S, Takeya H, Iwanaga S
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1824 Issue: 1 Pages: 164-76
- DOI
  10.1016/j.bbapap.2011.04.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659238, KAKENHI-PUBLICLY-23121536, KAKENHI-PROJECT-23570156
[Journal Article] ADAMTS13研究の最先端2012
- Author(s)
  宮田敏行, 小亀浩市, 秋山正志, 坂野史朗, 中山大輔, 武田壮一
- Journal Title
  
  臨床血液
  
  Volume: 53(7) Pages: 672-679
- NAID
  130004501705
- Data Source
  KAKENHI-PROJECT-23570156
[Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction2012
- Author(s)
  Doi M, Matsui H, Takeda H, Saito Y, Takeda M, Matsunari Y, Nishio K, Shima M, Banno F, Akiyama M, Kokame K, Miyata T, Sugimoto M.
- Journal Title
  
  Thromb Haemost
  
  Volume: 108 Pages: 1236-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] ADAMTS13研究の最先端2012
- Author(s)
  宮田敏行、小亀浩市、秋山正志、坂野史明、中山大輔、武田壮一
- Journal Title
  
  臨床血液
  
  Volume: 53 Pages: 672-679
- NAID
  130004501705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] Enzymatic Toxins from Snake Venom : Structural Characterization and Mechanism of Catalysis (Review article)2011
- Author(s)
  Kang TS, Georgieva D, Genov N, Murakami MT, Sinha M, Kumar RP, Kaur P, Kumar S, Dey S, Sharma S, Vrielink A, Betzel C, Takeda S, Arni RK, Singh TP, Kini RM.
- Journal Title
  
  FEBS J.
  
  Volume: 278 Pages: 4544-4576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570156
[Journal Article] VWF切断酵素ADAMTS13のエキソサイト認識機構2010
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Journal Title
  
  生化学第82巻、第10号
  
  Pages: 950-956
- NAID
  10027502769
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T.
- Journal Title
  
  Acta crystallogr Sect F 65
  
  Pages: 739-742
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Journal Title
  
  Acta Crystallogr Sect F Struct Biol Cryst Commun 65(Pt7)
  
  Pages: 739-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T.
- Journal Title
  
  Proc Natl Acad Sci USA 106
  
  Pages: 19274-19279
- NAID
  10026400518
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Three-dimensional domain architecture of the ADAM family proteinases (review article)2009
- Author(s)
  Takeda S
- Journal Title
  
  Semin Cell Dev Biol 20
  
  Pages: 146-152
- Data Source
  KAKENHI-PROJECT-19370047
[Journal Article] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Journal Title
  
  Proc Natl Acad Sci USA 106(46):
  
  Pages: 19274-19279
- NAID
  10026400518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Three-dimensional domain architecture of the ADAM family proteinases2008
- Author(s)
  Takeda S.
- Journal Title
  
  Semin Cell Dev Biol (prepublished online) doi:10.1016/j.semcdb.2008.07.009
- NAID
  40016835265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-80332279
[Journal Article] 血管の破壊毒素: 明らかになったADAM 型細胞表面プロテアーゼの結晶構造2008
- Author(s)
  荒木聡彦、五十嵐智子、武田壮一
- Journal Title
  
  表面 46(4)
  
  Pages: 24-33
- Data Source
  KAKENHI-PROJECT-19370047
[Journal Article] 血管の破壊毒素:明らかになったADAM型細胞表面プロテアーゼの結晶構造2008
- Author(s)
  荒木聡彦、五十嵐智子、武田壮一
- Journal Title
  
  表面 46(4)
  
  Pages: 24-33
- Data Source
  KAKENHI-PROJECT-80332279
[Journal Article] Crystal structures of RVV-X: evolutionary gain of specificity by ADAM family proteinases2007
- Author(s)
  Takeda S, Igarashi T, Mori H
- Journal Title
  
  FEBS Lett 581
  
  Pages: 5859-5864
- Data Source
  KAKENHI-PROJECT-19370047
[Journal Article] Crystal structure of RVV-X : an example of evolutionary gain of specificity by ADAM proteinases2007
- Author(s)
  Takeda S., Igarashi T., Mori H.
- Journal Title
  
  FEBS Letters 581
  
  Pages: 5859-5864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370047
[Journal Article] Crystal structures of catrocollastatin /VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin /reprolysin family proteins2007
- Author(s)
  Igarashi T, Araki S, Mori H, Takeda S
- Journal Title
  
  FEBS Lett 581
  
  Pages: 2416-2422
- Data Source
  KAKENHI-PROJECT-19370047
[Journal Article] ADAM ファミリータンパク質のドメイン構造2007
- Author(s)
  武田壮一
- Journal Title
  
  生化学 79(11)
  
  Pages: 1051-1055
- NAID
  10019995782
- Data Source
  KAKENHI-PROJECT-19370047
[Journal Article] ADAMファミリータンパク質のドメイン構造2007
- Author(s)
  武田壮一
- Journal Title
  
  生化学 79
  
  Pages: 1051-1055
- NAID
  10019995782
- Data Source
  KAKENHI-PROJECT-19370047
[Journal Article] 蛇毒メタロプロテアーゼの結晶構造とADAM ファミリーの基質認識機構2007
- Author(s)
  武田壮一
- Journal Title
  
  日本結晶学会誌 49
  
  Pages: 192-197
- NAID
  10019748218
- Data Source
  KAKENHI-PROJECT-19370047
[Journal Article] 蛇毒メタロプロテアーゼの結晶構造とADAMファミリーの基質認識機構2007
- Author(s)
  武田壮一
- Journal Title
  
  日本結晶学会誌 49
  
  Pages: 192-197
- NAID
  10019748218
- Data Source
  KAKENHI-PROJECT-19370047
[Journal Article] Preparation of protein crystals for X-ray structural study2006
- Author(s)
  Soichi Takeda
- Journal Title
  
  Methods in Molecular Medicine 129(2)
  
  Pages: 291-303
- Data Source
  KAKENHI-PROJECT-16687007
[Journal Article] Crystal structure of troponin and the molecular mechanism of muscle regulation2005
- Author(s)
  Soichi Takeda
- Journal Title
  
  Journal of Electron Microscopy 54(Suppl ement 1)
- Data Source
  KAKENHI-PROJECT-16687007
[Journal Article] 蛇毒メタロプロテアーゼの立体構造とラッセルクサリヘビ毒素によるX 因子活性化機構
- Author(s)
  武田壮一
- Journal Title
  
  血栓止血学会誌 (印刷中)
- NAID
  10026117504
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] ヘビ毒由来のプロテアーゼの立体構造と作用機構2015
- Author(s)
  武田壮一
- Organizer
  第15回日本蛋白質科学会年会、ワークショップ
- Place of Presentation
  あわぎんホール(徳島市)
- Year and Date
  2015-06-14
- Invited
- Data Source
  KAKENHI-PROJECT-26440040
[Presentation] マウス急性心筋梗塞モデルにおけるADAMTS13の心筋保護作用2013
- Author(s)
  土井政明, 松井英人, 竹田征治, 斎藤能彦, 武田麻衣子, 松成泰典, 西尾健治, 嶋緑倫, 坂野史明, 秋山正志, 小亀浩市, 宮田敏行, 杉本充彦
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] Protective role of ADAMTS13 for myocardium in mouse model of experimental myocardial infarction2012
- Author(s)
  Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, Mitsuhiko Sugimoto.
- Organizer
  54th American Society of Hematology, Annual Meeting and Exposition
- Place of Presentation
  Atlanta, USA.
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] Snake venom metalloproteinases; Structure, function and relevance to the mammalian ADAM/ADAMTS family proteins2012
- Author(s)
  Takeda S
- Organizer
  17th World Congress of the International Society on Toxinology
- Place of Presentation
  Hilton Hawaian Village, Honolulu, Hawai
- Invited
- Data Source
  KAKENHI-PROJECT-23570156
[Presentation] Structural basis of coagulation factor V recognition for cleavage by RVV-V2012
- Author(s)
  Soichi Takeda
- Organizer
  17th World Congress of the International Society on Toxinology
- Place of Presentation
  Hilton Hawaian Village, Honolulu, Hawaii
- Invited
- Data Source
  KAKENHI-PUBLICLY-23121536
[Presentation] ADAMTS13 improving the cell engraftment efficacy in mouse model of bone marrow transplantation2012
- Author(s)
  Hideto Matsui, Masaaki Doi, Yasunori Matsunari, Maiko Takeda, Kenji Nishio, Midori Shima, Kenji Soejima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, Mitsuhiko Sugimoto.
- Organizer
  54th American Society of Hematology, Annual Meeting and Exposition
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] Snake venom metalloproteinases; Structure, function and relevance to the mammalian ADAM/ADAMTS family proteins2012
- Author(s)
  Soichi Takeda
- Organizer
  Concurrent session-34: Structure/Function of Venom, 17th World Congress of the International Society on Toxinology
- Place of Presentation
  Honolulu, Hawaii
- Invited
- Data Source
  KAKENHI-PROJECT-23570156
[Presentation] Snake venom metalloproteinases; Structure, function and relevance to the mammalian ADAM/ADAMTS family proteins2012
- Author(s)
  Soichi Takeda
- Organizer
  17th World Congress of the International Society on Toxinology
- Place of Presentation
  Hilton Hawaian Village, Honolulu, Hawaii
- Invited
- Data Source
  KAKENHI-PUBLICLY-23121536
[Presentation] P475S型ADAMTS13タンパク質の部分立体構造決定2011
- Author(s)
  秋山正志、中山大輔、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-23570156
[Presentation] P475S型ADAMTS13の非触媒領域の立体構造決定2011
- Author(s)
  中山大輔, 秋山正志, 武田壮一, 小亀浩市, 高木淳一, 宮田敏行
- Organizer
  第16回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-23570156
[Presentation] Structural basis for ADAMTS13 function2011
- Author(s)
  Masashi Akiyama, Daisuke Nakayama, Soichi Takeda, Koichi Kokame, Junichi Takagi, Toshiyuki Miyata.
- Organizer
  XXIII Congress of the International Society of Thrombosis and Haemostasis (ISTH2011)
- Place of Presentation
  Kyoto International Conference Center
- Data Source
  KAKENHI-PROJECT-23570156
[Presentation] Structural basis of factor V recognition by russell's viper venom proteinase RVV-V2011
- Author(s)
  Daisuke Nakayama, Youssef Ben Ammar, Soichi Takeda.
- Organizer
  XXIII Congress of the International Society of Thrombosis and Haemostasis (ISTH2011)
- Place of Presentation
  Kyoto International Conference Center
- Data Source
  KAKENHI-PROJECT-23570156
[Presentation] Structural changes of troponin by cardiomyopathy-causing mutations2011
- Author(s)
  藤原悟、松尾龍人、松本富美子、小田俊郎、武田荘一
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  兵庫県立大学(姫路)
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-21510236
[Presentation] Structural analysis of troponin mutants causing cardiomyopathy by small-angle X-ray scattering2010
- Author(s)
  藤原悟、米澤康滋、松本富美子、小田俊郎、武田荘一
- Organizer
  第48回日本生物物理学会年会
- Place of Presentation
  東北大学(仙台)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21510236
[Presentation] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.(受賞講演)2010
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] X線解析によるADAMTS13の部分立体構造の決定とエキソサイトの同定(口演)2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第32回日本血栓止血学会学術集会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] DAMTS13の部分結晶構造とフォンビルブロンド因子認識・切断機構2009
- Author(s)
  武田壮一
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-20057036
[Presentation] X線解析によるADAMTS13の部分立体構造の決定とエキソサイトの同定2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第32回日本血栓止血学会学術総会
- Place of Presentation
  北九州市
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Crystal structure of the exosites-containing fragment of ADAMTS13.(口演、Abstract Symposia)2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Organizer
  XXII Congress of the International Society on Thrombosis and Haemositasis
- Place of Presentation
  アメリカ・ボストン市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Crystal structre of the exosite-containing fragment of ADAMTS13.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi T, Miyata T
- Organizer
  XXII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  アメリカ・ボストン
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] ADAMTS13非触媒ドメインの結晶構造解析とvon Willebrand因子に対する複数の非連続エキソサイトの同定(ポスター)2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] ADAMTS13非触媒ドメインの結晶構造解析とvon Willebrand因子に対する複数の非連続エキソサイトの同定2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Identification of multiple discontinuous exosites of ADAMTS13.(ポスター)2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Organizer
  The MMP Gordon Research Conference 2009
- Place of Presentation
  スイス・Les Diableret市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] 蛇毒ホモログの結晶構造から見えてきたADAMファミリープロテアーゼの立体構造と作用機構2008
- Author(s)
  武田壮一
- Organizer
  シンポジウム「膜近傍におけるプロテオリシス」第60回日本細胞生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-80332279
[Presentation] 蛇毒高分子量メタロプロテアーゼの結晶構造と作用機構2008
- Author(s)
  武田壮一
- Organizer
  第55回毒素シンポジウム
- Place of Presentation
  ラフォーレ山中湖(山梨県)
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-80332279
[Presentation] 蛇毒ホモログの結晶構造から見えてきたADAM ファミリープロテアーゼの立体構造と作用機構2008
- Author(s)
  武田壮一
- Organizer
  シンポジウム「膜近傍におけるプロテオリシス」
- Place of Presentation
  第60 回日本細胞生物学会年
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] ADAM プロテアーゼの立体構造と基質認識機構2008
- Author(s)
  武田壮一
- Organizer
  国立循環器病センター・東海大学医学部合同シンポジウム「近未来の革新的医療を志向するnano-medicine 研究とpersonal medicine 研究」
- Place of Presentation
  東海大学伊勢原校舎会議室
- Year and Date
  2008-12-15
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] ADAMプロテアーゼの立体構造と基質認識機構2008
- Author(s)
  武田壮一
- Organizer
  シンポジウム「近未来の革新的医療を志向する nano-medicine 研究と personal-medicine 研究」
- Place of Presentation
  東海大学伊勢原校舎会議室
- Year and Date
  2008-12-15
- Data Source
  KAKENHI-PROJECT-80332279
[Presentation] 発生・分化・病態に関わるADAM プロテアーゼ‐出血蛇毒素の結晶構造から見えてきたADAM の作用機構2008
- Author(s)
  武田壮一
- Organizer
  シンポジウム「生体分子による生物間の攻撃と防御」
- Place of Presentation
  東京大学弥生講堂・一条ホール
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] ラッセルクサリヘビ由来血液凝固第X因子活性化プロテアーゼRVV-Xの結晶構造2008
- Author(s)
  武田壮一, 五十嵐智子, 盛英三
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2008-06-11
- Data Source
  KAKENHI-PROJECT-80332279
[Presentation] ラッセルクサリヘビ由来血液凝固第X 因子活性化プロテアーゼRVV-X の結晶構造2008
- Author(s)
  武田壮一、盛英三、五十嵐智子
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2008-06-11
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] 蛇毒高分子量メタロプロテアーゼの結晶構造と作用機構2008
- Author(s)
  武田壮一
- Organizer
  第55 回毒素シンポジウム
- Place of Presentation
  ラフォーレ山中湖(山梨県)
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] 発生・分化・病態に関わるADAMプロテアーゼ-出血蛇毒の結晶構造から見えてきたADAMの作用機構2008
- Author(s)
  武田壮一
- Organizer
  シンポジウム「生体分子による生物間の攻撃と防御」
- Place of Presentation
  東京大学弥生講堂・一条ホール
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-80332279
[Presentation] 蛇毒高分子量メタロプロテアーゼの結晶構造から見えてきたADAMファミリータンパク質の基本構造2007
- Author(s)
  武田壮一
- Organizer
  BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会合同大会),「ベノミクス・毒生物ゲノムプロジェクト」ワークショップ
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] ヘビ毒メタロプロテアーゼのX線結晶構造解析によるADAMタンパク質の基本構造の解明2007
- Author(s)
  五十嵐智子、荒木聡彦、盛英三、武田壮一
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2007-05-26
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] Snake venom metalloproteinases : crystal structures and relationship to the mammalian ADAM family proteins2007
- Author(s)
  Takeda S.
- Organizer
  The 5th Aso International Meeting(AIM) Thrombosis, Hemostasis, and Vascular Science
- Place of Presentation
  Aso, Kumamoto, Japan
- Year and Date
  2007-05-19
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] ヘビ毒メタロプロテアーゼのX 線結晶構造解析によるADAM タンパク質の基本構造の解明2007
- Author(s)
  五十嵐智子、荒木聡彦、盛英三、武田壮一
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2007-05-26
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] Snake venom metalloproteinases: crystal structures and relationship to the mammalian ADAM family proteins2007
- Author(s)
  Takeda S
- Organizer
  The 5th Aso International Meeting (AIM) Thrombosis, Hemostasis, and Vascular Science
- Place of Presentation
  Aso, Kumamoto, Japan
- Year and Date
  2007-05-19
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] 蛇毒高分子量メタロプロテアーゼの結晶構造から見えてきたADAM ファミリータンパク質の基本構造2007
- Author(s)
  武田壮一
- Organizer
  BMB2007(第30 回日本分子生物学会年会・第80 回日本生化学会大会合同大会), 「ベノミクス・毒生物ゲノムプロジェクト」ワークショップ
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] ADAMs'MDC domain architecture revealed by the crystal structures of snake venom metalloproteinases2007
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference: Matrix Metalloproteinases
- Place of Presentation
  Il Ciocco, Barga, Italy
- Year and Date
  2007-06-06
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] ADAMs' MDC domain architecture revealed by the crystal structures of snake venom metalloproteinases2007
- Author(s)
  Takeda S.
- Organizer
  Gordon Research Conference : Matrix Metalloproteinases
- Place of Presentation
  Il Ciocco, Barga, Italy
- Year and Date
  2007-06-06
- Data Source
  KAKENHI-PROJECT-19370047
[Presentation] Structural basis for ADAMTS13 function.
- Author(s)
  Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemositasis
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] Structural basis of coagulation factor V recognition for cleavage by RVV-V
- Author(s)
  Soichi Takeda
- Organizer
  International Society of Thrombosis and Hemostasis (ISTH) Meeting, Registry of Exogenous factors, 17th World Congress of the International
- Data Source
  KAKENHI-PROJECT-23570156
[Presentation] P475S型ADAMTS13タンパク質の部分立体構造決定」（ポスター）第84回日本生化学会大会
- Author(s)
  秋山正志、中山大輔、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23570155

1. KOKAME Koichi (40270730)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. AKIYAMA Masashi (30298179)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
3. MASUDA Michitaka (00190364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. FUJIWARA Satoru (10354888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. ODA Toshiro (20321739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. MATSUMOTO Fumiko (80321818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. NAKAGAWA Hiroshi (20379598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUO Tatsuhito (60623907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. WAKABAYASHI Shigeo (70158583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. IWATA Yuko (80171908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NISHITANI Tomoe (50393244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HISAMITSU Takashi (50327946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. KOBAYASHI Soushi (50511531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SHIMADA Naoko (60600385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KAMAUCHI Shinya (00397564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAKAO Shu (30646956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 宮田敏行 (90183970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. BEN Ammar Youssef (90463273)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. IGARASHI Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
20. IMOTO Hitomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 武谷浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKEDA SOUICHI 武田 壮一

TAKEDA Soichi 武田 壮一

Research Projects

Research Products

Co-Researchers

Structural basis of substrate recognition and regulation by ADAM/ADAMTS family proteinasesPrincipal Investigator

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止血血栓形成に関わる複合体プロテアーゼの構造生物学的研究Principal Investigator

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高分子量プロテアーゼを介した細胞外シグナリングの構造生物学的研究Principal Investigator

Principal Investigator

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Review Section

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Molecular mechanism for regulaiton of ion transporter via lipid signaling and its structural basis

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Crystal structure analysis for the pathogenesis of thrombosis

Principal Investigator

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Structural study for understanding the molecular mechanism of ectodomain shedding by ADAM family proteinasesPrincipal Investigator

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Protein pathology of cardiomyopathy-related mutants of troponin

Principal Investigator

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ADAMTS13の基質認識・切断に対する細胞外環境の効果

Principal Investigator

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Research Category

Review Section

Research Institution

Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.

Principal Investigator

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Crystal structure and regulation of Fer

Principal Investigator

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Structural and functional analysis of ADAM family proteinsPrincipal Investigator

Principal Investigator

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ADAMファミリー関連タンパク質の立体構造と作用機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Institution

トロポニン・トロポミオシン複合体のX線結晶構造解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

TAKEDA SOUICHI 武田壮一

TAKEDA Soichi 武田壮一

[Book] 輸送体結合蛋白質の同定と複合体の構造解析 " トランスポートソームの世界編:金井好克, 竹島浩, 森泰生, 久保義弘"2011