HISASUE Masaharu 久末正晴

… Alternative Names

久末正晴ヒサスエマサハル

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Researcher Number	80333144
Other IDs
External Links
Affiliation (Current)	2025: 麻布大学, 獣医学部, 教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 麻布大学, 獣医学部, 教授 2020 – 2023: 麻布大学, 獣医学部, 准教授 2008 – 2018: 麻布大学, 獣医学部, 准教授 2007: 麻布大学, 獣医学部, 講師 2006: 麻布大, 獣医学部, 講師 2004 – 2005: Azabu University, School of Veterinary Medicine, Instructor, 獣医学部, 講師 2001 – 2003: Azabu University, Faculty of Veterinary Medicine, assistant, 獣医学部, 助手
Review Section/Research Field	Principal Investigator Veterinary medical science / Clinical veterinary science / Basic Section 42020:Veterinary medical science-related / Applied veterinary science Except Principal Investigator Basic Section 42020:Veterinary medical science-related / Clinical veterinary science / Veterinary medical science / Integrative animal science / Hematology / Applied veterinary science
Keywords	Principal Investigator 骨髄 / 分化誘導 / 幹細胞 / 皮膚 / 再生 / 肝臓 / 犬 / 直接転換 / 肝細胞 / イヌ … More / ウイルスベクター / ダイレクトリプログラミング / 分化 / 線維芽細胞 / 赤血球 / 白血球 / 血小板 / CD45 / レンチウイルス / iPS / 繊維芽細胞 / 血液 / 繊維症 / 犬肝臓 / 移植 / PAS染色 / アルブミン / CD45f / c-Kit / α-フェトプロティン / 肝細胞増殖因子 / 肝臓細胞 / 骨髄細胞 / 分化誘導療法 / ビタミンK2 / 骨髄異形成症候群 / 急性白血病 / ネコ白血病ウイルス / 猫 … More Except Principal Investigator イヌ / 再生医療 / iPS細胞 / ゲノム / 獣医学 / 進化 / Refrex-1 / ウイルス進化 / FeLV / ERV-DC / 猫白血病ウイルス / 共進化 / 内在性レトロウイルス / 受容体 / c-Met / HGF / 犬 / MDM2 / レトロウイルス / ネコ / 再生医療製品 / 運動器疾患 / ウイルス組換え / 抗ウイルス分子 / Restriction Factor / 霊長類 / 発癌 / ウイルス受容体 / Retrovirus / 抵抗性因子 / 再生獣医療 / 獣医再生医療 / センダイウイルスベクター / 血液 / 多能性幹細胞 / 家猫 / 発現制御 / 遺伝学 / ウイルス / ネコ科動物 / 家畜化 / FcERV-gamma4 / 抗ウイルス活性 / 葉酸トランスポーター / ウイルス変異 / 病原性発現 / 生命進化 / 内在性ウイルス / regenerative medicine / placental extract / hepatocyte / canine / bone marrow / C-Met / 肝臓 / 幹細胞 / 胎盤抽出物 / 肝細胞 / 骨髄細胞 / p21CIP1 / cell cycle / leukemia / myelodysplastic syndrome / differentiation / apoptosis / vitamin D3 / vitamin K2 / 急性白血病 / ビタミンD3 / 細胞周期 / 白血病 / 分化 / ビタミンK2 / 骨髄異形成症候群 / アポトーシス / P-glycoprotein / Clonarity / Feline leukemia virus / Multidrug resistance / Telomerase / Telomere / Tumor marker / P糖蛋白 / P53 / 猫 / アトピー性皮膚炎 / T細胞エピトープ / Cry j 1 / DNAワクチン / P糖蛋白質 / クローナリティー / 猫白血病ウイルス(FeLV) / p53 / 薬剤耐性 / テロメラーゼ / テロメア / 腫瘍マーカー / マウス乳癌ウイルス / 症例 / 乳腺腫瘍 / MMTV / 感染 / 伴侶動物 Less

低分子化合物誘導CLiP細胞によるイヌ人工肝開発は肝移植および治療薬開発を加速するPrincipal Investigator
- Principal Investigator
  
  久末正晴
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Azabu University
Establishment of basic technology for the development of veterinary regenerative medicine products using clinically applicable canine iPS cells
- Principal Investigator
  
  枝村一弥
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Nihon University
Physiological function of endogenous retroviruses in the host and tumorigenesis by altering their function.
- Principal Investigator
  
  Nishigaki Kazuo
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Yamaguchi University
Direct reprogramming to differentiate into hepatocyte-like cells from canine cutaneous fibroblastPrincipal Investigator
- Principal Investigator
  
  Hisasue Masaharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Veterinary medical science
- Research Institution
  Azabu University
Domestication and co-option of endogenous retroviruses
- Principal Investigator
  
  NISHIGAKI KAZUO
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  Yamaguchi University
Investigation of erythroid differentiation using transgene-free canine and feline induced pluripotent stem cells
- Principal Investigator
  
  Hatoya Shingo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Osaka Prefecture University
Differentiation of hematopoietic cell from Cutaneous fibroblasts by direct reprogramingPrincipal Investigator
- Principal Investigator
  
  Hisasue Masaharu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Veterinary medical science
- Research Institution
  Azabu University
Establishment of liver regenerative medicine by autologous transplantation in dogPrincipal Investigator
- Principal Investigator
  
  HISASUE Masaharu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Azabu University
乳腺腫瘍の犬や猫にマウス乳癌ウイルス(MMTV)は感染しているか?
- Principal Investigator
  
  Tsuchiya Ryo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Clinical veterinary science
- Research Institution
  Azabu University
イヌの骨髄細胞から分化した肝臓細胞の性状および機能解析に関する研究Principal Investigator
- Principal Investigator
  
  久末正晴
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Azabu University
Studies on regenerative medicine by using bone marrow stem cell in intractable hepatic diseases
- Principal Investigator
  
  YAMADA Takatsugu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Azabu University
ネコの血液腫瘍におけるビタミンK2による分化誘導療法の検討Principal Investigator
- Principal Investigator
  
  久末正晴
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Azabu University
Establishment of Vitamin K2 Therapy in Myelodysplastic Syndromes
- Principal Investigator
  
  MIYAZAWA Keisuke
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
Usefulness of tumor markers in veterinary medicine
- Principal Investigator
  
  TSUJIMOTO Hajime
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  THE UNIVERSITY OF TOKYO

All 2019 2017 2013 2012 2011 2005 2004 2003

All Journal Article Presentation Book

[Book] 獣医再生医療基礎&ステップアップ　. 獣医再生医療の基本的概念と可能性2019
- Author(s)
  久末正晴
- Total Pages
  20
- Publisher
  インターズー
- ISBN
- Data Source
  KAKENHI-PROJECT-16K15050
[Journal Article] AKT capture by feline leukemia virus.2017
- Author(s)
  Kawamura M, Umehara D, Odahara Y, Miyake A, Ngo MH, Ohsato Y, Hisasue M, Nakaya MA, Watanabe S, Nishigaki K.
- Journal Title
  
  Archives of　Virology
  
  Volume: 162(4) Issue: 4 Pages: 1031-1036
- DOI
  10.1007/s00705-016-3192-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04602, KAKENHI-PROJECT-15K08138
[Journal Article] Accumulation of Xenotransplanted Canine Bone Marrow Cells in NOD/SCID/γcnull Mice with Acute Hepatitis Induced by CCl42013
- Author(s)
 Kato T, Hisasue M, Segawa K, Fujimoto A, Makiishi E, Neo S, Yasuno K, Kobayashi R, Tsuchiya R.
- Journal Title
 
 Journal of Veterinary Medical Science
 
 Volume: 75 Issue: 7 Pages: 847-855
- DOI
 10.1292/jvms.12-0530
- NAID
 130003362149
- ISSN
 0916-7250, 1347-7439
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22580371
[Journal Article] Accumulation of xenotransplanted canine bone marrow cells in NOD/SCID/γcnull mice with hepatitis induced by CCl42013
- Author(s)
  Takashi Kato, Masaharu Hisasue, Kazuhito Segawa, Ayumi Fujimoto, Eri Makiishi, Sakurako Neo, Kyohei Yasuno, Ryosuke Kobayashi and Ryo Tsuchiya
- Journal Title
  
  J. Vet. Med. Sci
  
  Volume: 75(7) Pages: 845-855
- Data Source
  KAKENHI-PROJECT-22580371
[Journal Article] Comparative investigation of canine Babesia gibsoni infction using polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA).2005
- Author(s)
  Watanabe, T., Hisasue, M., Souma, T.et al.
- Journal Title
  
  J. Jpn. Vet. Med. Assoc. 58
  
  Pages: 622-626
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] Molecular Cloning of the canine c-Met/HGF receptor and its expression in normal and regenerated liver2005
- Author(s)
  Neo S, Kansaku N, Furuich M, Watanabe M, Hisamatsu S, Ohno K, Hisasue M, Tsuchiya R, Yamada T
- Journal Title
  
  J.Vet.Med.Sci (In press)
- NAID
  130000448251
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] 犬のBabesia gibson自然症例におけるPCR法及びELISA法による診断の比較2005
- Author(s)
  渡辺征, 久末正晴, 相馬武久他
- Journal Title
  
  日獣会誌 58
  
  Pages: 622-626
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] In vitro selective suppression of feline myeloid colony formation is attributable to molecularly cloned strain of feline leukemia virus with unique long terminal repeat2005
- Author(s)
  Nagashima N, Hisasue M, et al.
- Journal Title
  
  Res Vet Sci 78
  
  Pages: 151-154
- Data Source
  KAKENHI-PROJECT-17780240
[Journal Article] In vitro selective suppression of feline myeloid colony formation by a molecularly cloned strain of feline leukemia virus with unique long terminal repeat2005
- Author(s)
  Nagashima N, Hisasue M, Nishigaki K, Miyazawa Y, Kano R, Hasegawa
- Journal Title
  
  Res in Vet Sci (in press)
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] Treatment of chronic lymphocytic leukaemia in three dogs with melphalan and prednisolone2004
- Author(s)
  Fujino, Y, Sawamura, S, Kurakawa, N, Hisasue, M, Masuda, K, Ohno, K, Tsujimoto, H
- Journal Title
  
  J Small Anim Pract 45
  
  Pages: 298-303
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] Aggregability and post-transfusion survival of canine platelets in stored whole blood2003
- Author(s)
  Tsuchiya R, Yagura H, Hachiya Y, Mochizuki T, Furuichi M, Hisasue M, Kobayashi K, Yamada T
- Journal Title
  
  J.Vet.Med.Sci 65
  
  Pages: 825-829
- NAID
  10013231052
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] Molecular detection and characterization of haemobartomella felis in domestic cats in Japan employing sequence-specific polymerase c hain reaction(SS-PCR)2003
- Author(s)
  Watanabe M., Hisasue M., Hashizaki K., et al.
- Journal Title
  
  J. Vet. Med. Sci. 65
  
  Pages: 1111-1114
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] Molecular detection and characterization of Haemobartonella fe lis in domestic cats in Japan employing sequence-specific polymerase chain reaction(SS-PCR)2003
- Author(s)
  Watanabe M., Hisasue M., Hashizaki K.et al.
- Journal Title
  
  J. Vet. Med. Sci. 65
  
  Pages: 1111-1114
- NAID
  110003886135
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580294
[Presentation] Regenerative therapy in small animal practice2019
- Author(s)
  久末正晴
- Organizer
  第5回　国際組織工学・再生医療学会　世界会議2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15050
[Presentation] イヌ骨髄由来間葉系幹細胞から肝細胞様細胞へのダイレクトリプログラミング2019
- Author(s)
  新田卓、草刈雄登、山田陽子、久末正晴
- Organizer
  第14回　日本獣医再生医療学会　年次大会
- Data Source
  KAKENHI-PROJECT-16K15050
[Presentation]2013
- Author(s)
  加藤崇、久末正晴、瀬川和仁、藤本あゆみ、安野恭平、小林亮介、根尾櫻子、土屋亮
- Organizer
  第12回日本再生医療学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22580371
[Presentation] 四塩化炭素急性肝障害NOGマウスに対するイヌ骨髄細胞投与の検討2012
- Author(s)
  加藤崇、久末正晴、瀬川和仁、藤本あゆみ、安野恭平、小林亮介、根尾櫻子、土屋亮
- Organizer
  第19回肝細胞研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22580371
[Presentation] NOGマウスを利用したイヌ骨髄細胞の障害肝へのHoming作用の解析2012
- Author(s)
  加藤崇、久末正晴、瀬川和仁、藤本あゆみ、根尾櫻子、小林亮介、土屋亮
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手
- Data Source
  KAKENHI-PROJECT-22580371
[Presentation] 犬の骨髄細胞からの肝細胞の分化誘導2011
- Author(s)
  久末正晴
- Organizer
  獣医内科学アカデミー
- Place of Presentation
  横浜
- Year and Date
  2011-03-12
- Data Source
  KAKENHI-PROJECT-22580371
[Presentation] NOD/shi-scid,IL-2γnull(NOG)マウスにおける肝障害モデル作製に関する研究2011
- Author(s)
  加藤崇、久末正晴、根尾櫻子、藤本あゆみ、土屋亮
- Organizer
  第152回日本獣医学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22580371

1. HATOYA Shingo (40453138)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Tsuchiya Ryo (30188586)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MDARAME Hiroo (20173768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OGIHARA Kikumi (50154381)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMADA Takatsugu (20126460)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. NEO Sakurako (50532107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. TSUJIMOTO Hajime (60163804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. NISHIGAKI KAZUO (20401333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 三宅在子 (20548622)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. SASAKI Nobuo (60107414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MASUDA Kenichi (40313077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OHNO Koichi (90294660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OKUDA Masaru (10325243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MIYAZAWA Keisuke (50209897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IKEBUCHI Keinji (20175194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAKANISHI Mahito (10172355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 阪口雅弘 (20170590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 杉浦喜久弥 (30171143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 竹中重雄 (10280067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 中川草 (70510014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 枝村一弥 (80366624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 水野満 (00733908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 村田大紀 (00772683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 塩澤誠司 (10447039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NAKAMURA Takuro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Suzuki Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 白石明郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HISASUE Masaharu 久末 正晴

久末 正晴 ヒサスエ マサハル

Research Projects

Research Products

Co-Researchers

低分子化合物誘導CLiP細胞によるイヌ人工肝開発は肝移植および治療薬開発を加速するPrincipal Investigator

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Direct reprogramming to differentiate into hepatocyte-like cells from canine cutaneous fibroblastPrincipal Investigator

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Differentiation of hematopoietic cell from Cutaneous fibroblasts by direct reprogramingPrincipal Investigator

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Establishment of liver regenerative medicine by autologous transplantation in dogPrincipal Investigator

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イヌの骨髄細胞から分化した肝臓細胞の性状および機能解析に関する研究Principal Investigator

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ネコの血液腫瘍におけるビタミンK2による分化誘導療法の検討Principal Investigator

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HISASUE Masaharu 久末正晴

久末正晴ヒサスエマサハル

[Book] 獣医再生医療基礎&ステップアップ　. 獣医再生医療の基本的概念と可能性2019

[Journal Article] Accumulation of Xenotransplanted Canine Bone Marrow Cells in NOD/SCID/γ<sub>c</sub><sup>null</sup> Mice with Acute Hepatitis Induced by CCl<sub>4</sub>2013