HISASUE Masaharu 久末正晴

… Alternative Names

Researcher Number	80333144
Other IDs
External Links
Affiliation (Current)	2021: 麻布大学, 獣医学部, 准教授
Affiliation (based on the past Project Information) *help	2020: 麻布大学, 獣医学部, 准教授 2008 – 2018: 麻布大学, 獣医学部, 准教授 2007: 麻布大学, 獣医学部, 講師 2006: 麻布大, 獣医学部, 講師 2004 – 2005: Azabu University, School of Veterinary Medicine, Instructor, 獣医学部, 講師 2001 – 2003: Azabu University, Faculty of Veterinary Medicine, assistant, 獣医学部, 助手
Review Section/Research Field	Principal Investigator Clinical veterinary science / Veterinary medical science / Applied veterinary science Except Principal Investigator Clinical veterinary science / Applied veterinary science / Hematology / Integrative animal science / Veterinary medical science / Basic Section 42020:Veterinary medical science-related
Keywords	Principal Investigator 骨髄 / 犬 / 肝臓 / 再生 / 皮膚 / 幹細胞 / 分化誘導 / 猫 / ネコ白血病ウイルス / 急性白血病 … More Except Principal Investigator イヌ / ネコ / レトロウイルス / MDM2 / 再生医療 / HGF / c-Met / 内在性レトロウイルス / 進化 / 獣医学 / 伴侶動物 / 感染 / MMTV / 乳腺腫瘍 / 症例 / マウス乳癌ウイルス / 腫瘍マーカー / テロメア / テロメラーゼ / 薬剤耐性 / p53 / 猫白血病ウイルス(FeLV) / クローナリティー / P糖蛋白質 / DNAワクチン / Cry j 1 / T細胞エピトープ / アトピー性皮膚炎 / 犬 / 猫 / P53 / P糖蛋白 / Tumor marker / Telomere / Telomerase / Multidrug resistance / Feline leukemia virus / Clonarity / P-glycoprotein / アポトーシス / 骨髄異形成症候群 / ビタミンK2 / 分化 / 白血病 / 細胞周期 / ビタミンD3 / 急性白血病 / vitamin K2 / vitamin D3 / apoptosis / differentiation / myelodysplastic syndrome / leukemia / cell cycle / p21CIP1 / 骨髄細胞 / 肝細胞 / 胎盤抽出物 / 幹細胞 / 肝臓 / C-Met / bone marrow / canine / hepatocyte / placental extract / regenerative medicine / 内在性ウイルス / 生命進化 / 病原性発現 / ウイルス変異 / 受容体 / 葉酸トランスポーター / 共進化 / 抗ウイルス活性 / 猫白血病ウイルス / ERV-DC / FcERV-gamma4 / FeLV / ウイルス進化 / Refrex-1 / 家畜化 / ネコ科動物 / ウイルス / 遺伝学 / ゲノム / 発現制御 / 家猫 / iPS細胞 / 多能性幹細胞 / 血液 / センダイウイルスベクター / 獣医再生医療 / 再生獣医療 / ウイルス受容体 Less

内在性レトロウイルス依存性の宿主因子機能と機能変更による腫瘍化Ongoing
- Principal Investigator
  
  西垣一男
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Yamaguchi University
Direct reprogramming to differentiate into hepatocyte-like cells from canine cutaneous fibroblastPrincipal Investigator
- Principal Investigator
  
  Hisasue Masaharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Veterinary medical science
- Research Institution
  Azabu University
Domestication and co-option of endogenous retroviruses
- Principal Investigator
  
  NISHIGAKI KAZUO
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  Yamaguchi University
Investigation of erythroid differentiation using transgene-free canine and feline induced pluripotent stem cells
- Principal Investigator
  
  Hatoya Shingo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Osaka Prefecture University
Differentiation of hematopoietic cell from Cutaneous fibroblasts by direct reprogramingPrincipal Investigator
- Principal Investigator
  
  Hisasue Masaharu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Veterinary medical science
- Research Institution
  Azabu University
Establishment of liver regenerative medicine by autologous transplantation in dogPrincipal Investigator
- Principal Investigator
  
  HISASUE Masaharu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Azabu University
乳腺腫瘍の犬や猫にマウス乳癌ウイルス(MMTV)は感染しているか?
- Principal Investigator
  
  Tsuchiya Ryo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Clinical veterinary science
- Research Institution
  Azabu University
イヌの骨髄細胞から分化した肝臓細胞の性状および機能解析に関する研究Principal Investigator
- Principal Investigator
  
  久末正晴
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Azabu University
Studies on regenerative medicine by using bone marrow stem cell in intractable hepatic diseases
- Principal Investigator
  
  YAMADA Takatsugu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Azabu University
ネコの血液腫瘍におけるビタミンK2による分化誘導療法の検討Principal Investigator
- Principal Investigator
  
  久末正晴
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Azabu University
Establishment of Vitamin K2 Therapy in Myelodysplastic Syndromes
- Principal Investigator
  
  MIYAZAWA Keisuke
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
Usefulness of tumor markers in veterinary medicine
- Principal Investigator
  
  TSUJIMOTO Hajime
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  THE UNIVERSITY OF TOKYO

All 2019 2017 2013 2012 2011 2005 2004 2003

All Journal Article Presentation Book

[Book] 獣医再生医療基礎&ステップアップ　. 獣医再生医療の基本的概念と可能性2019
- Author(s)
  久末正晴
- Total Pages
  20
- Publisher
  インターズー
- ISBN
- Data Source
  KAKENHI-PROJECT-16K15050
[Journal Article] AKT capture by feline leukemia virus2017
- Author(s)
  Kawamura M, Umehara D, Odahara Y, Miyake A, Ngo MH, Ohsato Y, Hisasue M, Nakaya MA, Watanabe S, Nishigaki K.
- Journal Title
  
  Archives of Virology
  
  Volume: 162(4) Pages: 1031-1036
- DOI
  10.1007/s00705-016-3192-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04602, KAKENHI-PROJECT-15K08138
[Journal Article] Accumulation of xenotransplanted canine bone marrow cells in NOD/SCID/γcnull mice with hepatitis induced by CCl42013
- Author(s)
  Takashi Kato, Masaharu Hisasue, Kazuhito Segawa, Ayumi Fujimoto, Eri Makiishi, Sakurako Neo, Kyohei Yasuno, Ryosuke Kobayashi and Ryo Tsuchiya
- Journal Title
  
  J. Vet. Med. Sci
  
  Volume: 75(7) Pages: 845-855
- Data Source
  KAKENHI-PROJECT-22580371
[Journal Article] Accumulation of Xenotransplanted Canine Bone Marrow Cells in NOD/SCID/γcnull Mice with Acute Hepatitis Induced by CCl42013
- Author(s)
 Kato T, Hisasue M, Segawa K, Fujimoto A, Makiishi E, Neo S, Yasuno K, Kobayashi R, Tsuchiya R.
- Journal Title
 
 J. Vet. Med. Sci.
 
 Volume: 75 Issue: 7 Pages: 847-855
- DOI
 10.1292/jvms.12-0530
- NAID
 130003362149
- ISSN
 0916-7250, 1347-7439
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22580371
[Journal Article] 犬のBabesia gibson自然症例におけるPCR法及びELISA法による診断の比較2005
- Author(s)
  渡辺征, 久末正晴, 相馬武久他
- Journal Title
  
  日獣会誌 58
  
  Pages: 622-626
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] In vitro selective suppression of feline myeloid colony formation by a molecularly cloned strain of feline leukemia virus with unique long terminal repeat2005
- Author(s)
  Nagashima N, Hisasue M, Nishigaki K, Miyazawa Y, Kano R, Hasegawa
- Journal Title
  
  Res in Vet Sci (in press)
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] In vitro selective suppression of feline myeloid colony formation is attributable to molecularly cloned strain of feline leukemia virus with unique long terminal repeat2005
- Author(s)
  Nagashima N, Hisasue M, et al.
- Journal Title
  
  Res Vet Sci 78
  
  Pages: 151-154
- Data Source
  KAKENHI-PROJECT-17780240
[Journal Article] Comparative investigation of canine Babesia gibsoni infction using polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA).2005
- Author(s)
  Watanabe, T., Hisasue, M., Souma, T.et al.
- Journal Title
  
  J. Jpn. Vet. Med. Assoc. 58
  
  Pages: 622-626
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] Molecular Cloning of the canine c-Met/HGF receptor and its expression in normal and regenerated liver2005
- Author(s)
  Neo S, Kansaku N, Furuich M, Watanabe M, Hisamatsu S, Ohno K, Hisasue M, Tsuchiya R, Yamada T
- Journal Title
  
  J.Vet.Med.Sci (In press)
- NAID
  130000448251
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] Treatment of chronic lymphocytic leukaemia in three dogs with melphalan and prednisolone2004
- Author(s)
  Fujino, Y, Sawamura, S, Kurakawa, N, Hisasue, M, Masuda, K, Ohno, K, Tsujimoto, H
- Journal Title
  
  J Small Anim Pract 45
  
  Pages: 298-303
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] Aggregability and post-transfusion survival of canine platelets in stored whole blood2003
- Author(s)
  Tsuchiya R, Yagura H, Hachiya Y, Mochizuki T, Furuichi M, Hisasue M, Kobayashi K, Yamada T
- Journal Title
  
  J.Vet.Med.Sci 65
  
  Pages: 825-829
- NAID
  10013231052
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] Molecular detection and characterization of haemobartomella felis in domestic cats in Japan employing sequence-specific polymerase c hain reaction(SS-PCR)2003
- Author(s)
  Watanabe M., Hisasue M., Hashizaki K., et al.
- Journal Title
  
  J. Vet. Med. Sci. 65
  
  Pages: 1111-1114
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15580294
[Journal Article] Molecular detection and characterization of Haemobartonella fe lis in domestic cats in Japan employing sequence-specific polymerase chain reaction(SS-PCR)2003
- Author(s)
  Watanabe M., Hisasue M., Hashizaki K.et al.
- Journal Title
  
  J. Vet. Med. Sci. 65
  
  Pages: 1111-1114
- NAID
  110003886135
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580294
[Presentation] イヌ骨髄由来間葉系幹細胞から肝細胞様細胞へのダイレクトリプログラミング2019
- Author(s)
  新田卓、草刈雄登、山田陽子、久末正晴
- Organizer
  第14回　日本獣医再生医療学会　年次大会
- Data Source
  KAKENHI-PROJECT-16K15050
[Presentation] Regenerative therapy in small animal practice2019
- Author(s)
  久末正晴
- Organizer
  第5回　国際組織工学・再生医療学会　世界会議2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15050
[Presentation]2013
- Author(s)
  加藤崇、久末正晴、瀬川和仁、藤本あゆみ、安野恭平、小林亮介、根尾櫻子、土屋亮
- Organizer
  第12回日本再生医療学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22580371
[Presentation] NOGマウスを利用したイヌ骨髄細胞の障害肝へのHoming作用の解析2012
- Author(s)
  加藤崇、久末正晴、瀬川和仁、藤本あゆみ、根尾櫻子、小林亮介、土屋亮
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手
- Data Source
  KAKENHI-PROJECT-22580371
[Presentation] 四塩化炭素急性肝障害NOGマウスに対するイヌ骨髄細胞投与の検討2012
- Author(s)
  加藤崇、久末正晴、瀬川和仁、藤本あゆみ、安野恭平、小林亮介、根尾櫻子、土屋亮
- Organizer
  第19回肝細胞研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22580371
[Presentation] 犬の骨髄細胞からの肝細胞の分化誘導2011
- Author(s)
  久末正晴
- Organizer
  獣医内科学アカデミー
- Place of Presentation
  横浜
- Year and Date
  2011-03-12
- Data Source
  KAKENHI-PROJECT-22580371
[Presentation] NOD/shi-scid,IL-2γnull(NOG)マウスにおける肝障害モデル作製に関する研究2011
- Author(s)
  加藤崇、久末正晴、根尾櫻子、藤本あゆみ、土屋亮
- Organizer
  第152回日本獣医学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22580371

1. HATOYA Shingo (40453138)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Tsuchiya Ryo (30188586)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MDARAME Hiroo (20173768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OGIHARA Kikumi (50154381)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMADA Takatsugu (20126460)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. NEO Sakurako (50532107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
7. TSUJIMOTO Hajime (60163804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. NISHIGAKI KAZUO (20401333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 三宅在子 (20548622)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. SASAKI Nobuo (60107414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MASUDA Kenichi (40313077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OHNO Koichi (90294660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OKUDA Masaru (10325243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MIYAZAWA Keisuke (50209897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IKEBUCHI Keinji (20175194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAKANISHI Mahito (10172355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 阪口雅弘 (20170590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 杉浦喜久弥 (30171143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 竹中重雄 (10280067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 中川草 (70510014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NAKAMURA Takuro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. Suzuki Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 白石明郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. NAKAYA Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HISASUE Masaharu 久末 正晴

久末 正晴 ヒサスエ マサハル

Research Projects

Research Products

Co-Researchers

内在性レトロウイルス依存性の宿主因子機能と機能変更による腫瘍化Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Direct reprogramming to differentiate into hepatocyte-like cells from canine cutaneous fibroblastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Domestication and co-option of endogenous retroviruses

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of erythroid differentiation using transgene-free canine and feline induced pluripotent stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Differentiation of hematopoietic cell from Cutaneous fibroblasts by direct reprogramingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of liver regenerative medicine by autologous transplantation in dogPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

乳腺腫瘍の犬や猫にマウス乳癌ウイルス(MMTV)は感染しているか?

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

イヌの骨髄細胞から分化した肝臓細胞の性状および機能解析に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on regenerative medicine by using bone marrow stem cell in intractable hepatic diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ネコの血液腫瘍におけるビタミンK2による分化誘導療法の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of Vitamin K2 Therapy in Myelodysplastic Syndromes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Usefulness of tumor markers in veterinary medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 獣医再生医療 基礎&ステップアップ . 獣医再生医療の基本的概念と可能性2019

Author(s)

Total Pages

HISASUE Masaharu 久末正晴

久末正晴ヒサスエマサハル

[Book] 獣医再生医療基礎&ステップアップ　. 獣医再生医療の基本的概念と可能性2019

[Journal Article] Accumulation of Xenotransplanted Canine Bone Marrow Cells in NOD/SCID/γ<sub>c</sub><sup>null</sup> Mice with Acute Hepatitis Induced by CCl<sub>4</sub>2013

[Presentation] イヌ骨髄由来間葉系幹細胞から肝細胞様細胞へのダイレクトリプログラミング2019