KOJIMA Nakao 小嶋仲夫

Researcher Number	80333178
External Links
Affiliation (based on the past Project Information) *help	2015: 鈴鹿医療科学大学, 医用工学部, その他 2015: 鈴鹿医療科学大学, 医用工学部, 非常勤講師 2013 – 2014: 名城大学, 薬学部, 教授 2004 – 2005: 名城大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Environmental pharmacy / Physical pharmacy Except Principal Investigator Risk sciences of radiation and chemicals / Chemical pharmacy
Keywords	Principal Investigator 8-oxodG / ROS / VOC / 活性酸素種 / metabolic activation / light irradiation / Structure-activity relationship / DNA damage / Environmental chemicals / P450 … More / 肝ミクロソーム / 光分解 / エチルベンゼン / 光活性化 / 酸化還元サイクル / 酸化的遺伝子損傷 / 化学発がん / 代謝活性化 / 光照射 / 構造活性相関 / 活性酸素 / 揮発性有機化合物 / 遺伝子損傷 / 環境化学物質 / 細胞内分布 / 抗がん作用 / 細胞内還元 / 細胞障害 / シスプラチン耐性 / ヒト卵巣がん / タイムラプス解析 / 薬物耐性 / グルタチオン / 酸化ストレス / 白金４価錯体 … More Except Principal Investigator DNA損傷 / シクロブタン型ピリミジンダイマー / 未分化因子 / 配列特異性 / ＤＮＡ損傷 / LC/MS/MS / 脱メチル化 / 受精卵 / 未分化マーカー / ゲノム修飾 / 紫外線照射 / マウス胚性幹細胞 / Lapachol / 肥厚性瘢痕由来線維芽細胞 / クマリン / フラボノイド / Citrus tachibana / 機能性成分 / マイヤーレモン / ロテノイド誘導体 / ケイヒ酸誘導体 / カルバゾールアルカロイド / NO 産生抑制活性 / カルバゾールキノン誘導体 / 細胞毒性 / ベンゾフェノン / ビフェニル誘導体 / キノリン-2,4-ジオンアルカロイド / ES・iPS細胞分化 / NO産生抑制活性 / 抗酸化活性 / がん細胞増殖抑制活性 / ヒスタミン放出抑制活性 / アポトーシス誘導活性 / 天然資源 Less

Determination of intra-cellular dynamics of platinum(IV) complexes using imaging techniquePrincipal Investigator
- Principal Investigator
  
  Kojima Nakao
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Suzuka University of Medical Science
  Meijo University
A picture of whole DNA modification induced by carcinogens: Whole-genome analysis for sequence specificity and vulnerability
- Principal Investigator
  
  OKAMOTO YOSHINORI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Meijo University
Research on active compounds from natural resources affecting the differentiation of ES and iPS cells
- Principal Investigator
  
  ITO CHIHIRO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Meijo University
Mechanism of DNA damaging by photo- and metabolic products of carcinogenic ethylbenzenePrincipal Investigator
- Principal Investigator
  
  KOJIMA Nakao
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Meijo University

All 2016 2015 2014 2013 2012 2011 2006 Other

All Journal Article Presentation

[Journal Article] DNA methylation dynamics in mouse preimplantation embryos revealed by mass spectrometry2016
- Author(s)
  Yoshinori Okamoto, Naoko Yoshida, Toru Suzuki, Nobuhiro Shimozawa, Maki Asami, Tomonari Matsuda, Nakao Kojima, Anthony C. F. Perry & Tatsuyuki Takada
- Journal Title
  
  Scientific Reports
  
  Volume: 該当しない Issue: 1 Pages: 19134-19134
- DOI
  10.1038/srep19134
- NAID
  120005822766
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14440, KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-25550036
[Journal Article] Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats.2015
- Author(s)
  Okamoto Y., Tobe T., Ueda K., Takada T., Kojima N.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: NA
- NAID
  130004904040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460047
[Journal Article] Thiol-mediated multiple mechanisms centered on selenodiglutathione determine selenium cytotoxicity against MCF-7 cancer cells.2015
- Author(s)
  Tobe T., Ueda K., Ando M., Okamoto Y., Kojima N.
- Journal Title
  
  J. Biol. Inorg. Chem.
  
  Volume: NA Issue: 4 Pages: 687-694
- DOI
  10.1007/s00775-015-1254-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25550036
[Journal Article] Thiol-mediated multiple mechanisms centered on selenodiglutathione determine selenium cytotoxicity against MCF-7 cancer cells.2015
- Author(s)
  Tobe T., Ueda K., Ando M., Okamoto Y., Kojima N.
- Journal Title
  
  J. Biol. Inorg. Chem.
  
  Volume: NA
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460047
[Journal Article] Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats2015
- Author(s)
  Okamoto Y, Tobe T, Ueda K, Takada T, Kojima N
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 40 Issue: 2 Pages: 235-242
- DOI
  10.2131/jts.40.235
- NAID
  130004904040
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23651248, KAKENHI-PROJECT-25550036
[Journal Article] Roles of glutathione-mediated metabolites in the anti-tumor effects of selenium2014
- Author(s)
  Takao Tobe, Koji Ueda, Yoshinori Okamoto, Motozumi Ando, Hiroyuki Nishida, Kazuo Ito, Nakao Kojima
- Journal Title
  
  J. Res. Inst. Meijo Univ.
  
  Volume: 13
- NAID
  40020207659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25550036
[Journal Article] Neural Differentiation of Pluripotent Stem Cells and Application for Metal-induced Neural Toxicity Study2014
- Author(s)
  Taniguchi Y., Tobe T., Hayami H., Okamoto Y., Ueda K., Takada T., Kojima N.
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 134 Issue: 7 Pages: 793-795
- DOI
  10.1248/yakushi.14-00017-3
- NAID
  130004756445
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2014-07-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460047, KAKENHI-PROJECT-25550036
[Journal Article] A simple and convenient synthesis of a stable isotope-labeled 5-hydroxymehtyl-2’-deoxycytidine, the sixth base in mammalian DNA2014
- Author(s)
  Takao Tobe，Yoshinori Okamoto，Tatsuyuki Takada，Nakao Kojima
- Journal Title
  
  J. Res. Inst. Meijo Univ.
  
  Volume: 13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25550036
[Journal Article] Effects of organic and inorganic mercury(II) on gene expression via DNA conformational changes.2014
- Author(s)
  Ueda K., Makino R., Tobe T., Okamoto Y., Kojima N.
- Journal Title
  
  Fund. Toxicol. Sci.
  
  Volume: 1 Pages: 73-79
- NAID
  130005083332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25550036
[Journal Article] PRDM14 promotes active DNA demethylation through the Ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells.2014
- Author(s)
  Okashita, N., Kumaki, Y., Ebi, K., Nishi, M., Okamoto, Y., Nakayama, M., Hashimoto, S., Nakamura, T., Sugasawa, K., Kojima, N., Takada, T., Okano, M. and Seki, Y.
- Journal Title
  
  Development
  
  Volume: 141 Issue: 2 Pages: 269-280
- DOI
  10.1242/dev.099622
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23116008, KAKENHI-PROJECT-23651248, KAKENHI-PROJECT-24241019, KAKENHI-PROJECT-24681040, KAKENHI-PROJECT-25550036
[Journal Article] Effects of organic and inorganic mercury(II) on gene expression via DNA conformational changes.2014
- Author(s)
  Ueda K., Makino R., Tobe T., Okamoto Y., Kojima N.
- Journal Title
  
  Fund. Toxicol. Sci.
  
  Volume: 1 Pages: 269-280
- NAID
  130005083332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460047
[Journal Article] Induction of the anticancer effects of cisplatin platinum(IV) derivatives against cisplatin-resistant human ovarian cancer cells.2013
- Author(s)
  Yoshinori Okamoto, Tsuyoshi Nakai, Motozumi Ando, Nakao Kojima
- Journal Title
  
  J. Res. Inst. Meijo Univ.
  
  Volume: 12 Pages: 35-41
- Data Source
  KAKENHI-PROJECT-25460047
[Journal Article] 環境化学物質の活性化による毒性発現2006
- Author(s)
  小嶋仲夫
- Journal Title
  
  名状大学総合学術研究所紀要 11(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590097
[Journal Article] Activation of chemicals in the environment.2006
- Author(s)
  Kojima
- Journal Title
  
  Bul.Res.Inst.(Meijo Univ.) 11 (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590097
[Presentation] 白金4価錯体によるシスプラチン耐性ヒト卵巣がん細胞障害作用への活性酸素種生成の寄与2016
- Author(s)
  岡本誉士典、植田康次、小嶋仲夫、神野透人
- Organizer
  日本酸化ストレス学会東海支部　第4回学術集会
- Place of Presentation
  鈴鹿
- Year and Date
  2016-02-06
- Data Source
  KAKENHI-PROJECT-25460047
[Presentation] DNA methylation dynamics in mouse preimplantation embryos revealed by mass spectrometry2016
- Author(s)
  Yoshinori Okamoto, Naoko Yoshida, Toru Suzuki, Nobuhiro Shimozawa, Maki Asami, Tomonari Matsuda, Nakao Kojima, Anthony C. F. Perry, and Tatsuyuki Takada
- Organizer
  International Symposium on "Epigenome Dynamics and Regulation in Germ Cells 2016"
- Place of Presentation
  京都
- Year and Date
  2016-02-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25550036
[Presentation] cis-Diammine-tetrachloro-platinum(IV) は活性酸素種生成を介してシスプラチン耐性ヒト卵巣がん細胞に障害作用を引き起こす2015
- Author(s)
  戸邊隆夫、清水崇光、野中志保、植田康次、岡本誉士典、小嶋仲夫、神野透人
- Organizer
  第68回日本酸化ストレス学会学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-25460047
[Presentation] マウス胚性幹細胞の発がん性多環芳香族炭化水素に対する感受性の比較2015
- Author(s)
  長谷川祥子、戸邊隆夫、若原美沙紀、植田康次、岡本誉士典、高田達之、小嶋仲夫、神野透人
- Organizer
  第61回日本薬学会東海支部総会・大会
- Place of Presentation
  名古屋
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-25550036
[Presentation] Anti-cancer effect of platinum(IV) complex against cisplatin-resistant human ovarian cancer2015
- Author(s)
  Yoshinori Okamoto, Takao Tobe, Koji Ueda, Nakao Kojima
- Organizer
  American Association for Cancer Research Annual Meeting 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460047
[Presentation] Anti-cancer effect of platinum(IV) complex against cisplatin-resistant human ovarian cancer2015
- Author(s)
  Yoshinori Okamoto, Takao Tobe, Koji Ueda, Nakao Kojima
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  フィラデルフィア、アメリカ
- Year and Date
  2015-04-22
- Data Source
  KAKENHI-PROJECT-25460047
[Presentation] Cytotoxicity of Pt(IV) complexes against cisplatin-resistant human ovarian cancer cells -Potential role of reactive oxygen species-2014
- Author(s)
  清水崇光、戸邊隆夫、清水香琳、本山美貴、岡本誉士典、植田康次、小嶋仲夫
- Organizer
  第24回金属の関与する生体関連反応シンポジウムSRM2014
- Place of Presentation
  京都
- Year and Date
  2014-06-14
- Data Source
  KAKENHI-PROJECT-25460047
[Presentation] 紫外線曝露によるマウス胚性幹細胞のp53非依存的細胞死2014
- Author(s)
  清水優希、戸邊隆夫、岡本誉士典、植田康次、高田達之、小嶋仲夫
- Organizer
  フォーラム2014：衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-25550036
[Presentation] Anti-cancer effects of Pt(IV) complex in cisplatin-resistant ovarian cancer cells2014
- Author(s)
  Takao Tobe, Karin Shimizu, Miki Motoyama, Koji Ueda, Yoshinori Okamoto, Nakao Kojima
- Organizer
  12th European Biological Inorganic Chemistry Conference
- Place of Presentation
  スイス、チューリッヒ
- Year and Date
  2014-08-27
- Data Source
  KAKENHI-PROJECT-25460047
[Presentation] Molecular mechanism analysis of cytotoxicity induced by platinum(IV) complexes against cisplatin-resistant human ovarian cancer2014
- Author(s)
  戸邊隆夫、清水香琳、本山美貴、植田康次、岡本誉士典、小嶋仲夫
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-03
- Data Source
  KAKENHI-PROJECT-25460047
[Presentation] Pt(IV)錯体の配位子依存的がん細胞障害性と細胞内分布挙動2013
- Author(s)
  清水香琳、戸邊隆夫、臼井健悟、徐　佳典、植田康次、岡本誉士典、小嶋仲夫
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25460047
[Presentation] Ligand-dependent influx/efflux pattern of Pt(IV) complexes and their relevance to cytotoxicity in human ovarian cancer cells2013
- Author(s)
  戸邊隆夫、臼井健吾、徐　佳典、植田康次、岡本誉士典、小嶋仲夫
- Organizer
  第23回金属の関与する生体関連反応シンポジウムSRM2013
- Place of Presentation
  武蔵野
- Data Source
  KAKENHI-PROJECT-25460047
[Presentation] 白金4価錯体による酸化的遺伝子損傷および配位子依存性2013
- Author(s)
  岡本誉士典、臼井健吾、徐　佳典、清水香琳、本山美貴、植田康次、小嶋仲夫
- Organizer
  第66回日本酸化ストレス学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25460047
[Presentation] 植物由来ゲニステイン誘導体のプレニル基水酸化によるエストロゲン受容体転写調節の正負変動2012
- Author(s)
  有田卓矢、岡本誉士典、岩田綾香、安井彩、山中彩歌、吉田将之、植田康次、井藤千裕、小嶋仲夫
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2012
- Place of Presentation
  岐阜
- Year and Date
  2012-11-18
- Data Source
  KAKENHI-PROJECT-23590026
[Presentation] 植物由来プレニル化ゲニステインの構造変化によるエストロゲン受容体転写調節の正負変動2012
- Author(s)
  有田卓矢、岡本誉士典、岩田綾香、安井彩、山中彩歌、吉田将之、植田康次、井藤千裕、小嶋仲夫
- Organizer
  フォーラム2012:衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-23590026
[Presentation] プレニル化イソフラボン類によるエストロゲン様活性とその構造的特徴2012
- Author(s)
  岡本誉士典、岩田綾香、安井彩、山中彩歌、植田康次、井藤千裕、小嶋仲夫
- Organizer
  日本食品化学学会第18回総会・学術大会
- Place of Presentation
  函館
- Year and Date
  2012-06-22
- Data Source
  KAKENHI-PROJECT-23590026
[Presentation] エストロゲン受容体転写調節作用を有する Garcinia 属植物由来化合物の構造的特徴2011
- Author(s)
  岡本誉士典、森　大貴、木村優里、榊原布尚、岩田綾香、井藤千裕、古川宏、小嶋仲夫
- Organizer
  第 56 回日本薬学会東海支部大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590026
[Presentation] エストロゲン受容体転写調節作用を有するGarcinia属植物由来化合物の構造的特徴2011
- Author(s)
  岡本誉士典、森大貴、木村優里、榊原布尚、岩田綾香、井藤千裕、古川宏、小嶋仲夫
- Organizer
  第56回日本薬学会東海支部大会
- Place of Presentation
  名古屋
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-23590026
[Presentation] プレニル化イソフラボン類によるエストロゲン様活性とその構造的特徴
- Author(s)
  岡本誉士典、岩田綾香、安井　彩、山中彩歌、植田康次、井藤千裕、小嶋仲夫
- Organizer
  日本食品化学学会第18回総会・学術大会
- Place of Presentation
  函館
- Data Source
  KAKENHI-PROJECT-23590026
[Presentation] 植物由来ゲニステイン誘導体のプレニル基水酸化によるエストロゲン受容体転写調節の正負変動
- Author(s)
  有田卓矢、岡本誉士典、岩田綾香、安井　彩、山中彩歌、吉田将之、植田康次、井藤千裕、小嶋仲夫
- Organizer
  日本病院薬剤師東海ブロック・日本薬学会東海支部合同学術大会2012
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-23590026

1. OKAMOTO Yoshinori (50512323)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
2. UEDA Koji (30351092)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. ITO CHIHIRO (60193497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. KAWANISHI Shosuke (10025637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HASHIZUME Kiyomatsu (50076733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TODA Chitose (00076738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAMURA Tomohumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 高田達之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 菅澤薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOJIMA Nakao 小嶋 仲夫

Research Projects

Research Products

Co-Researchers

Determination of intra-cellular dynamics of platinum(IV) complexes using imaging techniquePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A picture of whole DNA modification induced by carcinogens: Whole-genome analysis for sequence specificity and vulnerability

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on active compounds from natural resources affecting the differentiation of ES and iPS cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of DNA damaging by photo- and metabolic products of carcinogenic ethylbenzenePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] DNA methylation dynamics in mouse preimplantation embryos revealed by mass spectrometry2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats.2015

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Thiol-mediated multiple mechanisms centered on selenodiglutathione determine selenium cytotoxicity against MCF-7 cancer cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thiol-mediated multiple mechanisms centered on selenodiglutathione determine selenium cytotoxicity against MCF-7 cancer cells.2015

Author(s)

Journal Title

Data Source

[Journal Article] Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Roles of glutathione-mediated metabolites in the anti-tumor effects of selenium2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Neural Differentiation of Pluripotent Stem Cells and Application for Metal-induced Neural Toxicity Study2014

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] A simple and convenient synthesis of a stable isotope-labeled 5-hydroxymehtyl-2’-deoxycytidine, the sixth base in mammalian DNA2014

Author(s)

Journal Title

Data Source

[Journal Article] Effects of organic and inorganic mercury(II) on gene expression via DNA conformational changes.2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] PRDM14 promotes active DNA demethylation through the Ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells.2014

KOJIMA Nakao 小嶋仲夫