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KOBAYASHI Takahiko  小林 隆彦

ORCIDConnect your ORCID iD *help
Researcher Number 80333607
Affiliation (based on the past Project Information) *help 2015: 北海道大学, 医学(系)研究科(研究院), 研究員
2011 – 2015: 北海道大学, 医学(系)研究科(研究院), 客員研究員
2014: 北海道大学, 大学院医学研究科, 客員研究員
2013: 北海道大学, 大学院医学研究科, 客員研究 員
2009 – 2012: 北海道大学, 大学院・医学研究科, 客員研究員 … More
2008: 北海道大学, 医学部, 准教授
2004 – 2005: 北海道大学, 病院, 講師
2004: 北海道大学, 大学病院, 講師
2003: Hokkaido University, Hospital, Instructor, 医学部・歯学部附属病院, 講師
2002: 北海道大学, 医学部附属病院, 講師 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Obstetrics and gynecology
Except Principal Investigator
Gastroenterology / Gastroenterology / Experimental pathology
Keywords
Principal Investigator
HIF-1 / 抗癌剤耐性 / 薬剤耐性 / Hypoxia / Pancreatic Cancer / ドミナント・ネガティブ / 血管新生 / 低酸素適応 / 低酸素 / 膵癌 … More / RBM5 / 抗癌剤 / 子宮頚癌 / E6 / パピローマウイルス / p53 … More
Except Principal Investigator
adrenomedullin / 膵癌 / 抗癌剤耐性 / 薬剤耐性 / 血管新生 / AMF / HIF-1 / glycolysis / adrenomedullin antagonist / angiogenesis / pancreatic cancer / Glucose transporter / hypoglycemia / hypoxia / Hypoxin / 解糖系酵素 / 転移 / 適応応答 / アポトーシス / dominant negative HIF-1α / アドレノメジュリン / 低栄養 / 低酸素 / 肝癌発生 / 網羅的探索 / マイクロアレイ / RBM5 / RNA結合タンパク / 癌進展 / MMP-9 / Hypoxia Less
  • Research Projects

    (9 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (6 People)
  •  RNA binding proteins modulate drug sensitivity of cancer chemotherapy via EMT related proteins.Principal Investigator

    • Principal Investigator
      Kobayashi Takahiko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  An RNA binding protein, RBM5 modulates chemotherapeutic efficacy via the expression of p62.

    • Principal Investigator
      SHIMIZU Yuich
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  RBM5 plays important roles in the post-transcriptional regulation of mRNAs that are involved in the metabolism of chemotherapeutic reagents.

    • Principal Investigator
      KAWAKAMI Hiroshi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  RNA binding protein RBM5 modulates chemotherapy resistancePrincipal Investigator

    • Principal Investigator
      KOBAYASHI Takahiko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  Molecular Screening by Microarray analysis for Hepatocarcinogenesis.

    • Principal Investigator
      CHUMA Makoto
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  子宮頸癌でのパピローマウイルス蛋白E6によるp53阻害作用からの解除因子の探索Principal Investigator

    • Principal Investigator
      小林 隆彦
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Hokkaido University
  •  Molecular Targeted Therapy with Dominant Negative HIF-1 for Pancreatic CancerPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Takahiko
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  低酸素誘導転写因子(HIF-1)による低酸素適応応答を制御する薬剤の探索

    • Principal Investigator
      KOBAYASHI Masanobu
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  Development of therapy for pancreatic cancers which targets adaptation response to hypoxia.

    • Principal Investigator
      KOBAYASHI Masanobu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

All 2013 2011 2009 2006 2005 2004 2003

All Journal Article

  • [Journal Article] Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation2013

    • Author(s)
      Kobayashi T., Ozasa M., Miyashita K., Saga A., Miwa K., Saito M., Morioka M., Takeuchi M., Takenouchi N., Yabiku T., Kanno H., Yuzawa S., Tanino M., Tanaka S., Kawakami H., Asaka M., Sakamoto N.
    • Journal Title

      Intern. Med.

      Volume: 52 Issue: 18 Pages: 2051-2056

    • DOI

      10.2169/internalmedicine.52.9512

    • NAID

      130003365837

    • ISSN
      0918-2918, 1349-7235
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460921
  • [Journal Article] Knockdown of prothymosin α leads to apoptosis and developmental defects in zebrafish embryos.2013

    • Author(s)
      Emmanouilidou A., Karetsou Z., Tzima E., Kobayashi T., Papamarcaki T.
    • Journal Title

      Biochem Cell Biol

      Volume: 91 Issue: 5 Pages: 325-332

    • DOI

      10.1139/bcb-2012-0103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460921
  • [Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2011

    • Author(s)
      Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayashi M, Itoh H, Edamatsu H, Sutherland LC, Brachmann RK.
    • Journal Title

      Int J Cancer. 128(2)

      Pages: 304-318

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590752
  • [Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative turnor suppressor RBM5.2011

    • Author(s)
      Kobayashi T
    • Journal Title

      Int J Cancer

      Volume: 128 Pages: 304-318

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590752
  • [Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2011

    • Author(s)
      Kobayashi T
    • Journal Title

      Int J Cancer

      Volume: 128 Pages: 304-318

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590677
  • [Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2011

    • Author(s)
      Kobayashi T, Ishida J, Musashi M, Ota S, Y oshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayas hi M, Itoh H, Edamatsu H, Sutherland LC, B rachmann RK.
    • Journal Title

      Int J Cancer

      Volume: 128(2) Issue: 2 Pages: 304-318

    • DOI

      10.1002/ijc.25345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590677
  • [Journal Article] The influence of hepatitis B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma.2009

    • Author(s)
      Chuma M, Hige S, Kamiyama T, Meguro T, Nagasaka A, Nakanishi K, Yamamoto Y, Nakanishi M, Kohara T, Sho T, Yamamoto K, Horimoto H, Kobayashi T, Yokoo H, Matsushita M, Todo S, Asaka M.
    • Journal Title

      J Gastroenterol. 44(9)

      Pages: 991-999

    • NAID

      10025581551

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590752
  • [Journal Article] Overexpression of the Oncoprotein Prothymosin {alpha} Triggers a p53 Response that Involves p53 Acetylation.2006

    • Author(s)
      Kobayashi T.
    • Journal Title

      Cancer Res. 66・6

      Pages: 3137-3144

    • Data Source
      KAKENHI-PROJECT-16659443
  • [Journal Article] Overexpression of the oncoprotein prothymosin alpha triggers a p53 response that involves p53 acetylation.2006

    • Author(s)
      Kobayashi T., Wang T., Maezawa M., Kobayashi M., Ohnishi S., Hatanaka K., Hige H., Shimizu Y., Kato M., Asaka M, Tanaka J., Imamura M., Hasegawa K., Tanaka Y., Brachmann RK.
    • Journal Title

      Cancer Res. 66

      Pages: 3137-3144

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Overexpression of the Oncoprotein Prothymosin alpha Triggers a p53 Resnonse that Involves p53 Acetvlation2006

    • Author(s)
      Kobayashi T.
    • Journal Title

      Cancer Res. 66

      Pages: 3137-3144

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Overexpression of the Oncoprotein Prothymosin {alpha} Triggers a p53 Response that Involves p53 Acetylation.2006

    • Author(s)
      Kobayashi T.
    • Journal Title

      Cancer Res. 66・6

      Pages: 3137-3144

    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non hypoxic induction of HIF-1alpha.2005

    • Author(s)
      Kakinuma Y, Ando M, Kuwabara M, Katare RG, Okudela K, Kobayashi M, Sato T.
    • Journal Title

      FEBS Lett. 579

      Pages: 2111-2118

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Hypoxia suppresses the production of matrix metalloproteinases and the migration of humanmonocyte-derived dendritic cells.2005

    • Author(s)
      Zhao W, Darmanin S, Fu Q, Chen J, Cui H, Wang J, Okada F, Hamada JI, Hattori YI, Kondo T, Hamuro J, Asaka M, Kobayashi M.
    • Journal Title

      Eur J Immunol. 35

      Pages: 3468-3477

    • NAID

      120000956474

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Hypoxia induces adhesion molecules on cancer cells : A missing link between Warburg effect and induction of selectin-ligand carbohydrates.2004

    • Author(s)
      Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kanangi R
    • Journal Title

      Proc.Natl.Acad.Sci.USA 101

      Pages: 8132-8137

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Dominant negative HIF-1a reduces tumorigenicity of pancreatic cancer cells through the suppression of hypoxia-inducible anaerobic metabolism.2003

    • Author(s)
      Chen J, Kobayashi M, Akakura N, Zhao S, Nakada K, Kuge Y, Tamaki N, Wang J, Shindo M, Higashino F, Seth P, Hosokawa M
    • Journal Title

      Am J Pathol. 162

      Pages: 1283-1291

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis.2003

    • Author(s)
      Ishikawa T, Chen J, Wang J, Okada F, Sugiyama T, Kobayashi T, Shindo M, Higashino F, Katoh H, Asaka M, Kondo T, Hosokawa M, Kobayashi M
    • Journal Title

      Oncogene 22

      Pages: 1238-1242

    • NAID

      120000955159

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • 1.  KOBAYASHI Masanobu (80241321)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 2.  CHUMA Makoto (30360910)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  KAWAKAMI Hiroshi (80399823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  SHIMIZU Yuich (90333608)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KOMATSU YOSHITO (60333598)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SHINDO Masanobu (20162802)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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