KOBAYASHI Takahiko 小林隆彦

Researcher Number	80333607
Affiliation (based on the past Project Information) *help	2015: 北海道大学, 医学(系)研究科(研究院), 研究員 2011 – 2015: 北海道大学, 医学(系)研究科(研究院), 客員研究員 2014: 北海道大学, 大学院医学研究科, 客員研究員 2013: 北海道大学, 大学院医学研究科, 客員研究員 2009 – 2012: 北海道大学, 大学院・医学研究科, 客員研究員 … More 2008: 北海道大学, 医学部, 准教授 2004 – 2005: 北海道大学, 病院, 講師 2004: 北海道大学, 大学病院, 講師 2003: Hokkaido University, Hospital, Instructor, 医学部・歯学部附属病院, 講師 2002: 北海道大学, 医学部附属病院, 講師 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Obstetrics and gynecology Except Principal Investigator Gastroenterology / Gastroenterology / Experimental pathology
Keywords	Principal Investigator HIF-1 / 抗癌剤耐性 / 薬剤耐性 / Hypoxia / Pancreatic Cancer / ドミナント・ネガティブ / 血管新生 / 低酸素適応 / 低酸素 / 膵癌 … More / RBM5 / 抗癌剤 / 子宮頚癌 / E6 / パピローマウイルス / p53 … More Except Principal Investigator adrenomedullin / 膵癌 / 抗癌剤耐性 / 薬剤耐性 / 血管新生 / AMF / HIF-1 / glycolysis / adrenomedullin antagonist / angiogenesis / pancreatic cancer / Glucose transporter / hypoglycemia / hypoxia / Hypoxin / 解糖系酵素 / 転移 / 適応応答 / アポトーシス / dominant negative HIF-1α / アドレノメジュリン / 低栄養 / 低酸素 / 肝癌発生 / 網羅的探索 / マイクロアレイ / RBM5 / RNA結合タンパク / 癌進展 / MMP-9 / Hypoxia Less

RNA binding proteins modulate drug sensitivity of cancer chemotherapy via EMT related proteins.Principal Investigator
- Principal Investigator
  
  Kobayashi Takahiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
An RNA binding protein, RBM5 modulates chemotherapeutic efficacy via the expression of p62.
- Principal Investigator
  
  SHIMIZU Yuich
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
RBM5 plays important roles in the post-transcriptional regulation of mRNAs that are involved in the metabolism of chemotherapeutic reagents.
- Principal Investigator
  
  KAWAKAMI Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
RNA binding protein RBM5 modulates chemotherapy resistancePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Takahiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
Molecular Screening by Microarray analysis for Hepatocarcinogenesis.
- Principal Investigator
  
  CHUMA Makoto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
子宮頸癌でのパピローマウイルス蛋白E6によるp53阻害作用からの解除因子の探索Principal Investigator
- Principal Investigator
  
  小林隆彦
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hokkaido University
Molecular Targeted Therapy with Dominant Negative HIF-1 for Pancreatic CancerPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Takahiko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  HOKKAIDO UNIVERSITY
低酸素誘導転写因子(HIF-1)による低酸素適応応答を制御する薬剤の探索
- Principal Investigator
  
  KOBAYASHI Masanobu
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Hokkaido University
Development of therapy for pancreatic cancers which targets adaptation response to hypoxia.
- Principal Investigator
  
  KOBAYASHI Masanobu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University

All 2013 2011 2009 2006 2005 2004 2003

All Journal Article

[Journal Article] Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation2013
- Author(s)
  Kobayashi T., Ozasa M., Miyashita K., Saga A., Miwa K., Saito M., Morioka M., Takeuchi M., Takenouchi N., Yabiku T., Kanno H., Yuzawa S., Tanino M., Tanaka S., Kawakami H., Asaka M., Sakamoto N.
- Journal Title
  
  Intern. Med.
  
  Volume: 52 Issue: 18 Pages: 2051-2056
- DOI
  10.2169/internalmedicine.52.9512
- NAID
  130003365837
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460921
[Journal Article] Knockdown of prothymosin α leads to apoptosis and developmental defects in zebrafish embryos.2013
- Author(s)
  Emmanouilidou A., Karetsou Z., Tzima E., Kobayashi T., Papamarcaki T.
- Journal Title
  
  Biochem Cell Biol
  
  Volume: 91 Issue: 5 Pages: 325-332
- DOI
  10.1139/bcb-2012-0103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460921
[Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2011
- Author(s)
  Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayashi M, Itoh H, Edamatsu H, Sutherland LC, Brachmann RK.
- Journal Title
  
  Int J Cancer. 128(2)
  
  Pages: 304-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590752
[Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative turnor suppressor RBM5.2011
- Author(s)
  Kobayashi T
- Journal Title
  
  Int J Cancer
  
  Volume: 128 Pages: 304-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590752
[Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2011
- Author(s)
  Kobayashi T
- Journal Title
  
  Int J Cancer
  
  Volume: 128 Pages: 304-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590677
[Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2011
- Author(s)
  Kobayashi T, Ishida J, Musashi M, Ota S, Y oshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayas hi M, Itoh H, Edamatsu H, Sutherland LC, B rachmann RK.
- Journal Title
  
  Int J Cancer
  
  Volume: 128(2) Issue: 2 Pages: 304-318
- DOI
  10.1002/ijc.25345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590677
[Journal Article] The influence of hepatitis B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma.2009
- Author(s)
  Chuma M, Hige S, Kamiyama T, Meguro T, Nagasaka A, Nakanishi K, Yamamoto Y, Nakanishi M, Kohara T, Sho T, Yamamoto K, Horimoto H, Kobayashi T, Yokoo H, Matsushita M, Todo S, Asaka M.
- Journal Title
  
  J Gastroenterol. 44(9)
  
  Pages: 991-999
- NAID
  10025581551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590752
[Journal Article] Overexpression of the Oncoprotein Prothymosin {alpha} Triggers a p53 Response that Involves p53 Acetylation.2006
- Author(s)
  Kobayashi T.
- Journal Title
  
  Cancer Res. 66・6
  
  Pages: 3137-3144
- Data Source
  KAKENHI-PROJECT-16659443
[Journal Article] Overexpression of the oncoprotein prothymosin alpha triggers a p53 response that involves p53 acetylation.2006
- Author(s)
  Kobayashi T., Wang T., Maezawa M., Kobayashi M., Ohnishi S., Hatanaka K., Hige H., Shimizu Y., Kato M., Asaka M, Tanaka J., Imamura M., Hasegawa K., Tanaka Y., Brachmann RK.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 3137-3144
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390222
[Journal Article] Overexpression of the Oncoprotein Prothymosin alpha Triggers a p53 Resnonse that Involves p53 Acetvlation2006
- Author(s)
  Kobayashi T.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 3137-3144
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390222
[Journal Article] Overexpression of the Oncoprotein Prothymosin {alpha} Triggers a p53 Response that Involves p53 Acetylation.2006
- Author(s)
  Kobayashi T.
- Journal Title
  
  Cancer Res. 66・6
  
  Pages: 3137-3144
- Data Source
  KAKENHI-PROJECT-15390222
[Journal Article] Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non hypoxic induction of HIF-1alpha.2005
- Author(s)
  Kakinuma Y, Ando M, Kuwabara M, Katare RG, Okudela K, Kobayashi M, Sato T.
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 2111-2118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390222
[Journal Article] Hypoxia suppresses the production of matrix metalloproteinases and the migration of humanmonocyte-derived dendritic cells.2005
- Author(s)
  Zhao W, Darmanin S, Fu Q, Chen J, Cui H, Wang J, Okada F, Hamada JI, Hattori YI, Kondo T, Hamuro J, Asaka M, Kobayashi M.
- Journal Title
  
  Eur J Immunol. 35
  
  Pages: 3468-3477
- NAID
  120000956474
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390222
[Journal Article] Hypoxia induces adhesion molecules on cancer cells : A missing link between Warburg effect and induction of selectin-ligand carbohydrates.2004
- Author(s)
  Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kanangi R
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101
  
  Pages: 8132-8137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390222
[Journal Article] Dominant negative HIF-1a reduces tumorigenicity of pancreatic cancer cells through the suppression of hypoxia-inducible anaerobic metabolism.2003
- Author(s)
  Chen J, Kobayashi M, Akakura N, Zhao S, Nakada K, Kuge Y, Tamaki N, Wang J, Shindo M, Higashino F, Seth P, Hosokawa M
- Journal Title
  
  Am J Pathol. 162
  
  Pages: 1283-1291
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390222
[Journal Article] Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis.2003
- Author(s)
  Ishikawa T, Chen J, Wang J, Okada F, Sugiyama T, Kobayashi T, Shindo M, Higashino F, Katoh H, Asaka M, Kondo T, Hosokawa M, Kobayashi M
- Journal Title
  
  Oncogene 22
  
  Pages: 1238-1242
- NAID
  120000955159
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390222

1. KOBAYASHI Masanobu (80241321)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. CHUMA Makoto (30360910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. KAWAKAMI Hiroshi (80399823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SHIMIZU Yuich (90333608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KOMATSU YOSHITO (60333598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHINDO Masanobu (20162802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOBAYASHI Takahiko 小林 隆彦

Research Projects

Research Products

Co-Researchers

RNA binding proteins modulate drug sensitivity of cancer chemotherapy via EMT related proteins.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An RNA binding protein, RBM5 modulates chemotherapeutic efficacy via the expression of p62.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RBM5 plays important roles in the post-transcriptional regulation of mRNAs that are involved in the metabolism of chemotherapeutic reagents.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNA binding protein RBM5 modulates chemotherapy resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Screening by Microarray analysis for Hepatocarcinogenesis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

子宮頸癌でのパピローマウイルス蛋白E6によるp53阻害作用からの解除因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Targeted Therapy with Dominant Negative HIF-1 for Pancreatic CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

低酸素誘導転写因子(HIF-1)による低酸素適応応答を制御する薬剤の探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of therapy for pancreatic cancers which targets adaptation response to hypoxia.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of &beta;-Catenin: A Case Report and Literature Review of the Distribution of &beta;-Catenin Mutation2013

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Knockdown of prothymosin α leads to apoptosis and developmental defects in zebrafish embryos.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2011

Author(s)

Journal Title

Data Source

[Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative turnor suppressor RBM5.2011

Author(s)

Journal Title

Data Source

[Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2011

KOBAYASHI Takahiko 小林隆彦

[Journal Article] Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation2013