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NAGANO Isao  永野 功

ORCIDConnect your ORCID iD *help
Researcher Number 80335603
Other IDs
Affiliation (based on the past Project Information) *help 2003 – 2004: Okayama University, Hospital, lecturer, 医学部・歯学部附属病院, 講師
2002: 岡山大学, 医学部附属病院, 助手
2002: Okayama University, Hospital, Lecturer, 医学部附属病院, 講師
2001: 岡山大学, 医学部・附属病院, 助手
Review Section/Research Field
Principal Investigator
Neurology
Except Principal Investigator
Neurology / Neurology
Keywords
Principal Investigator
neural precursor cell / IGF-1 / Flk-1 / hypoxia / VEGF / SOD1 / ALS / Ref-1 / Pl3-K / ERK … More / Akt / PI3-K / stem cell / transgenic mouse / G93A / motor neuron … More
Except Principal Investigator
IGF-1 / SOD1 / トランスジェニックマウス / transgenic mice / ALS / 筋萎縮性側索硬化症 / hypoxia / neurotrophic factor / intrathecal administration / Amyotrophic lateral sclerosis / モデル動物 / 神経栄養因子 / 髄腔内投与 / Melatonin / passive immunization / Vaccine / Treatment / Neurofibrillary tangles / amyloid / Alzheimer's disease / メラトニン / 受動免疫 / ワクチン / 治療 / 神経原線維変化 / アミロイド / アルツハイマー病 / 遺伝子治療 / SOD / ミトコンドリア / アポトーシス / 酸化ストレス Less
  • Research Projects

    (5 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (11 People)
  •  The study for the molecular mechanisms and the newly developed treatment for ALS

    • Principal Investigator
      ABE Koji
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Okayama University
  •  Development of treatment for Alzheimer's disease using transgenic animal models.

    • Principal Investigator
      SHOJI Mikio
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Development of the Treatment of Amyotrophic Lateral Sclerosis (ALS) with Neural Stem CellsPrincipal Investigator

    • Principal Investigator
      NAGANO Isao
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Okayama University
  •  トランスジェニックマウスを用いた遺伝性筋萎縮性側索硬化症の発症機序に関する研究

    • Principal Investigator
      真邊 泰宏
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Okayama University
  •  Comprehensive research on pathomechanism therapy of ALS and

    • Principal Investigator
      ABE Koji
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Okayama University

All 2005 2004 2003

All Journal Article

  • [Journal Article] Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis.2005

    • Author(s)
      Nagano I, Shiote M, Murakami T, Kamada H, Hamakawa Y, Matsubara E, Yokoyama M, Morita K, Shoji M, Abe K.
    • Journal Title

      Neurological Research (In press)

    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis.2005

    • Author(s)
      Nagano I, Shiote M, Murakami T, Kamada H, Hamakawa Y, Matsubara E, Yokoyama M, Morita K, Shoji M, Abe K.
    • Journal Title

      Neurological Research (In press)

    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of amyotrophic lateral sclerosis2005

    • Author(s)
      Nagano I, Ilieva H, Shiote M, Murakami T, Yokoyama M, Shoji M, Abe K
    • Journal Title

      Joumal of the Neurological Sciences 235

      Pages: 61-68

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SOD^G9JA transgenic mice2005

    • Author(s)
      Narai H, Nagano I, Ilieva H, Shiote M, Nagata T, Hayashi T, Shoji M, Abe K
    • Journal Title

      Joumal of Neuroscience Research 82

      Pages: 452-457

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SOD^<G93A> transgenic mice.2005

    • Author(s)
      Narai H, Nagano I, Ilieva H, Shiote M, Nagata T, Hayashi T, Shoji M, Abe K.
    • Journal Title

      Journal of Neuroscience Research 82

      Pages: 452-457

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Reduction of a VEGF receptor, Flk-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia.2005

    • Author(s)
      Shiote M, Nagano I, Ilieva H, murakami T, Narai H, Ohta Y, Nagata T, Shoji M, Abe K.
    • Journal Title

      Neuroscience 132

      Pages: 175-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis.2005

    • Author(s)
      Nagano I, Ilieva H, Shiote M, Murakami T, Yokoyama M, Shoji M, Abe K.
    • Journal Title

      J Neurol Sci. 235

      Pages: 61-8

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Reduction of a VEGF receptor, Flk-1, by antisense oligonucleotides induces motor Neuron death in rat spinal cord exposed to hypoxia2005

    • Author(s)
      Shiote M, Nagano I, Ilieva H, Murakami T, Narai H, Ohta Y, Nagata T, Shoji M, Abe K.
    • Journal Title

      Neuroscience 132

      Pages: 175-182

    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SOD (G93A) transgenic mice.2005

    • Author(s)
      Narai H, Nagano I, Ilieva H, Shiote M, Nagata T, Hayashi T, Shoji M, Abe K.
    • Journal Title

      Journal of the Neuroscience Research 82

      Pages: 452-7

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Prevention of spinal motor neuron death by IGF-1 associating with the signal transduction systems in SOD Tg mice.2005

    • Author(s)
      Narai H, Nagano I, Ilieva H, Shiote M, Nagata T, Hayashi T, Shoji M, Abe K.
    • Journal Title

      J.Neurosci.Res. 82

      Pages: 452-457

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia.2005

    • Author(s)
      Shiote M, Nagano I, Ilieva H, Murakami T, Narai H, Ohta Y, Nagata T, Shoji M, Abe K.
    • Journal Title

      Neuroscience 132

      Pages: 175-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis.2005

    • Author(s)
      Nagano I, Shiote M, Murakami T, Kamada H, Hamakawa Y, Matsubara E, Yokoyama M, Morita K, Shoji M, Abe K.
    • Journal Title

      Neurol Res. 27(7)

      Pages: 768-72

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia.2005

    • Author(s)
      Shiote M, Nagano I, Ilieva H, Murakami T, Narai H, Ohta Y, Nagata T, Shoji M, Abe K.
    • Journal Title

      Neuroscience 132(1)

      Pages: 175-182

    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxla.2005

    • Author(s)
      Shiote M, Nagano I, Ilieva H, Murakami T, Narai H, Ohta Y, Nagata T, Shoji M, Abe K.
    • Journal Title

      Neuroscience 132(1)

      Pages: 175-82

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis.2005

    • Author(s)
      Nagano I, Shiote M, Murakami T, Kamada H, Hamakawa Y, Matsubara E, Yokoyama M, Morita K, Shoji M, Abe K.
    • Journal Title

      Neurol.Res. 27

      Pages: 768-772

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of amyotrophic lateral sclerosis.2005

    • Author(s)
      Nagano I, Ilieva H, Shiote M, Murakami T, Yokoyama M, Shoji M, Abe K.
    • Journal Title

      Journal of the Neurological Sciences 235

      Pages: 61-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis.2005

    • Author(s)
      Nagano I, Shiote M, Murakami T, Kamada H, Hamakawa Y, Matsubara E, Yokoyama M, Morita K, Shoji M, Abe K.
    • Journal Title

      Neurological Research 27

      Pages: 768-772

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SOD(G93A) transgenic mice.2005

    • Author(s)
      Narai H, Nagano I, Ilieva H, Shiote M, Nagata T, Hayashi T, Shoji M, Abe K.
    • Journal Title

      Journal of the Neuroscience Research 82

      Pages: 452-457

    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis.2005

    • Author(s)
      Nagano I, Ilieva H, Shiote M, Murakami T, Yokoyama M, Shoji M, Abe K.
    • Journal Title

      J.Neurol.Sci. 235

      Pages: 61-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Reduction of a VEGF receptor, Flk-1, by antisense oligonucleotides induces motor Neuron death in rat spinal cord exposed to hypoxia2005

    • Author(s)
      Shiote M, Nagano I, Ilieva H, Murakami T, Narai H, Ohta Y, Nagata T, Shoji M, Abe K.
    • Journal Title

      Neuroscience 132

      Pages: 175-182

    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Reduction of a VEGF receptor, Flk-1, by antisense oligonucleotides induces motor Neuron death in rat spinal cord exposed to hypoxia2005

    • Author(s)
      Shiote M, Nagano I, Ilieva H, Murakami T, Narai H, Ohta Y, Nagata T, Shoji M, Abe K
    • Journal Title

      Neuroscience 132

      Pages: 175-182

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Improvement of SSPE by intrathecal infusion of α-IFN.2004

    • Author(s)
      Kurata T, Matsubara E, Yokoyama M, Nagano I, Shoji M, Abe K
    • Journal Title

      Neurology 63

      Pages: 398-399

    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] 片側顔面神経麻痺と舌下神経麻痺のみを呈した皮質梗塞の1例2004

    • Author(s)
      砂田典子, 出口健太郎, 永野功, 幡中邦彦, 山脇均, 藤木茂篤, 東海林幹夫, 阿部康二
    • Journal Title

      脳と神経 56

      Pages: 801-804

    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Improvement of SSPE by intrathecal infusion of α-IFN.2004

    • Author(s)
      Kurata T, Matsubara E, Yokoyama M, Nagano I, Shoji M, Abe K
    • Journal Title

      Neurology 63

      Pages: 398-399

    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Leber' s hereditary optic neuropathy with chorea and dementia resembling Huntington disease.2004

    • Author(s)
      Morimoto N, Nagano I, Deguchi K, Murakami T, Fushimi S, Shoji M, Abe K.
    • Journal Title

      Neurology 63

      Pages: 2451-2452

    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Leber's hereditary optic neuropathy with chorea and dementia resembling Huntington disease.2004

    • Author(s)
      Morimoto N, Nagano I, Deguchi K, Murakami T, Fushimi S, Shoji M, Abe K.
    • Journal Title

      Neurology 63

      Pages: 2451-2452

    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] 片側顔面神経麻痺と舌下神経麻痺のみを呈した皮質梗塞の1例2004

    • Author(s)
      砂田典子, 出口健太郎, 永野功, 幡中邦彦, 山脇均, 藤木茂篤, 東海林幹夫, 阿部康二
    • Journal Title

      脳と神経 56

      Pages: 801-804

    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Sustained induction of survival p-AKT and p-ERK slgnals after transient hypoxia in mice spinal cord with G93A mutant human SODI protein.2003

    • Author(s)
      Ilieva H, Nagano I, Murakami T, Shiote M, Shoji M, Abe K.
    • Journal Title

      J Neurol Sci. 215

      Pages: 57-62

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Ventral root avulsion leads to downregulation of GluR2 subunit in spinal motoneurons in adult rats.2003

    • Author(s)
      Nagano I, Murakami T, Shiote M, Abe K, Itoyama Y.
    • Journal Title

      Neuroscience 117

      Pages: 139-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Sustained induction of survival p-Akt and p-ERK signals after transient hypoxia in mice spinal cord with G93A mutant human SOD1 protein.2003

    • Author(s)
      Ilieva H, Nagano I, Murakami T, Shiote M, Shoji M, Abe K.
    • Journal Title

      Journal of the Neurological Sciences 215

      Pages: 57-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene.2003

    • Author(s)
      Murakami T, Ilieva H, Shiote M, Nagata T, Nagano I, Shoji M, Abe K.
    • Journal Title

      Brain Res. 989

      Pages: 231-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis.2003

    • Author(s)
      Nagano I, Murakami T, Shiote M, Manabe Y, Hadano S, Yanagisawa Y, Ikeda J-E, Abe K.
    • Journal Title

      Neurological Research 25

      Pages: 505-509

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis.2003

    • Author(s)
      Nagano I, Murakami T, Shiote M, Manabe Y, Hadano S, Yanagishawa Y, Ikeda JE, Abe K.
    • Journal Title

      Neurol.Res. 25

      Pages: 505-509

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis2003

    • Author(s)
      Nagano I, Murakami T, Shiote M, Manabe Y, Hadano S, Yanagisawa Y, Ikeda J-E, Abe K
    • Journal Title

      Neurological Research 25

      Pages: 505-509

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene.2003

    • Author(s)
      Murakami T, Ilieva H, Nagata T, Nagano I, Shoji M, Abe K.
    • Journal Title

      Brain Research 989

      Pages: 231-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Hypoxic induction of vascular endothelial growth factor is impaired in the spinal cord in of the mice with mutant human SOD1 gene.2003

    • Author(s)
      Nagano I, Murakam T, Shiote M, Ilieva H, Manabe Y, Shoji M, Abe K.
    • Journal Title

      International Congress Series 1252, Molecular Mechanism and Epochal Therapeutics of Ischemic Stroke and Demantia. (In : K.Abe, ed.)(Amsterdam : Elsevier Science B.V.)

      Pages: 57-63

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Hypoxic induction of vascular endothelial growh factor is selectively impaired in mice carrying the mutant SOD1 gene2003

    • Author(s)
      Murakami T, Ilieva H, Nagata T, Nagano I, Shoji M, Abe K
    • Journal Title

      Brain Research 989

      Pages: 231-237

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Sustained induction of survival p-AKT and p-ERK signals after transient hypoxia in mice spinal cord with G93A mutant human SOD1 protein.2003

    • Author(s)
      Ilieva H, Nagano I, Murakami T, Shiote M, Shoji M, Abe K.
    • Journal Title

      J.Neurol.Sci. 215

      Pages: 57-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390273
  • [Journal Article] Ventra root avulsion leads to downregulation of GluR2 subunit in spinal motoneurons in adult rats2003

    • Author(s)
      Nagano I, Murakami T, Shiote M, Abe K, Itoyama Y
    • Journal Title

      Neuroscience 117

      Pages: 139-146

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • [Journal Article] Ventra root avulsion leads to downregulation of GluR2 subunit in spinal motoneurons in adult rats.2003

    • Author(s)
      Nagano I, Murakami T, Shiote M, Abe K, Itoyama Y.
    • Journal Title

      Neuroscience 117

      Pages: 139-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570598
  • 1.  ABE Koji (20212540)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 40 results
  • 2.  SHOJI Mikio (60171021)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 18 results
  • 3.  MATSUBARA Etsuro (70219468)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  真邊 泰宏 (30325112)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  IKEDA Masaki (50222899)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  HONMOU Osamu (90285007)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  NAGAI Makiko (80420488)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  HAYASHI Takeshi (40314679)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 9.  割田 仁 (60325115)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  柏原 健一 (80204387)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  永田 哲也 (50362976)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results

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