KAKUMA TETSUYA 加隈哲也

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KAKUMA Tetsuya 加隈哲也

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Researcher Number	80343359
Affiliation (Current)	2023: 大分大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 大分大学, 保健管理センター, 准教授 2010 – 2015: 大分大学, 医学部, 講師 2014: 大分大学, 医学部内分泌代謝膠原病腎臓内科, 講師 2007 – 2008: Oita University, 医学部, 助教 2003 – 2005: 大分大学, 医学部, 助手 2002: Oita university, department of internal medicine 1, 医学部, 助手
Review Section/Research Field	Principal Investigator Applied health science / Metabolomics / Gastroenterology / Applied health science / Metabolomics / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Applied health science / Basic Section 59040:Nutrition science and health science-related / Applied health science / Endocrinology / Metabolomics / Environmental physiology (including Physical medicine and Nutritional physiology) / Metabolomics
Keywords	Principal Investigator インスリン / SREBP / レプチン / 肥満 / 過栄養性脂肪肝 / 炎症性サイトカイン / 脂肪肝 / チアゾリジン誘導体 / PPARγ / 膵β細胞特異的TNFα過剰発現マウス … More / 糖尿病抵抗性 / 肥満抵抗性 / 脂肪肝抵抗性 / グルカゴン / ソマトスタチン / AVP / CRH / UCP / FAS / IRS / 加齢 / 脳内脂質代謝 / 脂質代謝調節 / 脂肪酸組成 / ヒスタミン / アディポネクチン / pleiotropic効果 / Apelin / ピオグリタゾン / db / dbマウス / KKAyマウス / 脾臓摘出 / 脂肪性肝炎 / IL-10 / 摂食リズム障害 / 肥満症 / IL-10欠損マウス / ８オキソグアニン / 機能的グルカゴン低下 / 糖代謝 / 高脂肪食負荷 / 高ショ糖負荷 / 加齢負荷 / TNFα / STZ誘発糖尿病モデル / 交感神経活動 / 神経ヒスタミン / グレリン / AGRP / GLP1 / ストレプトゾトシン誘発インスリン依存性糖尿病モデルラット / 中枢性糖代謝改善 / 糖新生 / 糖利用 / Leptin / Streptozotocin induced diabetes / Sympathetic nerve activity / Neuronal histamine / Ghrelin / 免疫染色 / 肝臓メタボローム解析 / 脂肪合成低下 / 嫌気性代謝亢進 / アミノ酸代謝亢進 / インスリン分泌 / 迷走神経遮断 / 腸内細菌叢 / Firmicutes / Verrucomicrobia / 臓器間ネットワーク / 定期健康診断 / 糖代謝異常 / 脂質異常 / 肝機能障害 / 内臓脂肪型肥満 / 高度肥満 / 食育 / 保健指導 / 行動療法的方法論 / 糖尿病前症 … More Except Principal Investigator 肥満 / 神経ヒスタミン / 肥満症 / H1受容体 / リズム / エネルギー代謝 / ストレス / 視床下部 / 食行動 / メタボリックシンドローム / 脾臓 / IL-10 / IKBL / HLA / SNP / 糖尿病 / 小腸 / 炎症 / 内分泌学 / エストロゲン / オレキシン / 前頭 / 視交叉上核 / 時計遺伝子 / BMAL-1 / 高脂肪食 / サイトカイン / 肝門脈 / レプチン / 褐色脂肪組織 / アディポネクチン / 交換神経 / 交感神経 / hepatic-portal vein / leptin / feeding behavior / energy metabolism / brown adipose tissue / adiponectin / 膵α細胞 / グルカゴン / 1型糖尿病 / 2型糖尿病 / 抗GAD抗体 / マウス / 膵β細胞 / MIN6 / ゲノム / BRG1 / カルモジュリン / 転写因子 / pancreatic α cell / glucagon / type 1 diabetes mellitus / type 2 diabetes mellitus / anti-GAD antibody / GLP-1 / BDNF / アルツハイマー型認知症 / 脳内BDNF / 認知症 / 認知機能 / サルコペニア / 腸内環境 / マイオカイン / 外科治療 / 外科療法 / 肥満外科 / SARS-CoV-2 / ACE2 Less

肥満に伴う新型コロナウイルス感染の重症化に対するACE2の有用性
- Principal Investigator
  
  後藤孔郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Oita University
食育を目指した保健指導への挑戦：行動療法的方法論に基づいた糖尿病前症の対策Principal Investigator
- Principal Investigator
  
  加隈哲也
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Oita University
肥満外科治療による脳内の摂食エネルギー代謝調節因子の解析
- Principal Investigator
  
  正木孝幸
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Oita University
Importance of intestinal environment on the prevention of obesity-induced sarcopenia
- Principal Investigator
  
  GOTOH KORO
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Oita University
Examination of cognitive factor in obesity
- Principal Investigator
  
  Masaki Takayuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Oita University
過栄養性脂肪肝発症における膵臓―脳―肝臓の臓器間ネットワークと腸内細菌叢の関与Principal Investigator
- Principal Investigator
  
  加隈哲也
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Oita University
The role of spleen-derived IL-10 and portal GLP-1 levels in the prevention of obesity-induced dementia
- Principal Investigator
  
  Gotoh Koro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Oita University
The relationship between stress-induced hyperphagia and obesity
- Principal Investigator
  
  TAKAYUKI MASAKI
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Oita University
The approach for pathogenic mechanism of Type 1 diabetes using transgenic mice expressing TNFalpha selectively in pancreatic beta cellsPrincipal Investigator
- Principal Investigator
  
  Kakuma Tetsuya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Oita University
A novel role for preventing the development of metabolic syndrome
- Principal Investigator
  
  GOTOH KORO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Oita University
The investigation of feeding rhythm and obesity.
- Principal Investigator
  
  TAKAYUKI MASAKI
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Oita University
The clarification of pathophysiological mechanism for over-nutritional fatty liver and the involvement of DNA damage by oxygen radicalPrincipal Investigator
- Principal Investigator
  
  KAKUMA Tetsuya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Oita University
ストレスと肥満症:神経ヒスタミンによる脳内メカニズムの解明
- Principal Investigator
  
  吉松博信
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Oita University
Isolation of physiologically active substance regarding the pathogenesis and development of fatty liver under overeatingPrincipal Investigator
- Principal Investigator
  
  KAKUMA Tetsuya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Oita University
Neuronal histamine and H1 receptors regulate biological rhythm and energy metabolism
- Principal Investigator
  
  YOSHIMATSU Hironobu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Oita University
The isolation and characterization of anti-diabetic humoral factor mediated by leptin in hypothalamusPrincipal Investigator
- Principal Investigator
  
  KAKUMA Tetsuya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Oita University
脳内SREBPの摂食行動および脂質代謝調節における意義Principal Investigator
- Principal Investigator
  
  加隈哲也
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  大分医科大学
FUNCTION OF NOVEL GENE (BRG1) EXPRESSED IN PANCREATIC BETA CELLS AND IMPLICATION IN PATHOGENESIS OF DIABETES.
- Principal Investigator
  
  HAMAGUCHI Kazuyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Oita University
  大分医科大学
Hepatic-portal leptin sensor regulates energy metabolism
- Principal Investigator
  
  YOSHIMATSU Hironobu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  OITA MEDICAL UNIVERSITY

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All Journal Article Presentation

[Journal Article] 高齢2型糖尿病患者の骨格筋量指数に基づいた栄養指導の検討2021
- Author(s)
  足立和代、加隈哲也、利根哲子、廣田優子、平野薫、首藤麻美、小野宮子、田邉美保子
- Journal Title
  
  日本病態栄養学会雑誌
  
  Volume: 24(3) Pages: 121-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K11625
[Journal Article] α-Tocopherol suppresses hepatic steatosis by increasing CPT-1 expression in a mouse model of diet-induced nonalcoholic fatty liver disease.2020
- Author(s)
  Tokoro M, Gotoh K, Kudo Y, Hirashita Y, Iwao M, Arakawa M, Endo M, Oribe J, Masaki T, Honda K, Kakuma T, Seike M, Murakami K, Shibata H.
- Journal Title
  
  Obesity Science and Practice
  
  Volume: 4 Pages: 91-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01854
[Journal Article] α-Tocopherol suppresses hepatic steatosis by increasing CPT-1 expression in a mouse model of diet-induced nonalcoholic fatty liver disease.2020
- Author(s)
  Tokoro M, Gotoh K, Kudo Y, Hirashita Y, Iwao M, Arakawa M, Endo M, Oribe J, Masaki T, Honda K, Kakuma T, Seike M, Murakami K, Shibata H.
- Journal Title
  
  Obes Sci Pract.
  
  Volume: 7 Pages: 91-99
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11605
[Journal Article] Role of spleen-derived IL-10 in prevention of systemic low-grade inflammation by obesity [Review]2017
- Author(s)
  Gotoh K, Fujiwara K, Anai M, Okamoto M, Masaki T, Kakuma T, Shibata H.
- Journal Title
  
  Endocrine Journal
  
  Volume: 64 Issue: 4 Pages: 375-378
- DOI
  10.1507/endocrj.ej17-0060
  10.1507/endocrj.EJ17-0060
- NAID
  130005630429
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350896
[Journal Article] GLP-1 regulates beta-cell mass through brain-derived neurotrophic factor neurons in non-diabetic obese rats.2017
- Author(s)
  Ando H, Gotoh K, Fujiwara K, Mitsutomi K, Shimasaki T, Itateyama E, Anai M, Chiba S, Masaki T, Seike M, Kakuma T, Shibata H
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Pages: 807-817
- DOI
  10.1038/s41598-017-05371-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350896
[Journal Article] Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats.2017
- Author(s)
  Ando H, Gotoh K, Fujiwara K, Anai M, Chiba S, Masaki T, Kakuma T, Shibata H.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 5578-5578
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01721
[Journal Article] Pore alterations of the endothelial lining of rat fenestrated intestinal capillaries exposed to acute stress2016
- Author(s)
  Aosa T, Chiba S, Kitamura H, Ina K, Tatsukawa S, Moriwaki C, Wei H, Gotoh K, Masaki T, Kakuma T, Shibata H, Fujikura Y
- Journal Title
  
  Histol Histopathol
  
  Volume: 31 Pages: 807-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350897
[Journal Article] Pore alterations of the endotheliallining of rat fenestrated intestinal capillaries exposed to acute stress.2016
- Author(s)
  Aosa T, Chiba S, Kitamura H, Ina K, Tatsukawa S, Moriwaki C, Wei H, Gotoh K, Masaki T, Kakuma T, Shibata H, Fujikura Y.
- Journal Title
  
  Histol Histopathol.
  
  Volume: 31 Pages: 807-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350896
[Journal Article] Fulminant Type 1 Diabetes Mellitus with Anti-programmed Cell Death-1 Therapy2016
- Author(s)
  Okamoto M, Okamoto M, Gotoh K, Masaki T, Ozeki Y, Ando H, Anai M, Sato A, Yoshida Y, Ueda S, Kakuma T, Shibata H.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 7 Pages: 915-918
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350896
[Journal Article] Fulminant Type 1 Diabetes Mellitus with Anti-programmed Cell Death-1 Therapy2016
- Author(s)
  Okamoto M, Okamoto M, Gotoh K, Masaki T, Ozeki Y, Ando H, Anai M, Sato A, Yoshida Y, Ueda S, Kakuma T, Shibata H
- Journal Title
  
  J Diabetes Investig
  
  Volume: 7 Pages: 915-918
- DOI
  10.1111/jdi.12531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350897
[Journal Article] A clinical approach to brown adipose tissue in the para-aortic area of the human thorax.2015
- Author(s)
  Wei H, Chiba S, Moriwaki C, Kitamura H, Ina K, Aosa T, Tomonari K, Gotoh K, Masaki T, Katsuragi I, Noguchi H, Kakuma T, Hamaguchi K, Shimada T, Fujikura Y, Shibata H.
- Journal Title
  
  PLoS One.
  
  Volume: 10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350896
[Journal Article] Obesity-related chronic kidney disease is associated with spleen-derived IL-102013
- Author(s)
  Gotoh K, Inoue M, Masaki T, Chiba S, Shiraishi K, Shimasaki T, Matsuoka K, Ando H, Fujiwara K, Fukunaga N, Aoki K, Nawata T, Katsuragi I, Kakuma T, Seike M, Yoshimatsu H
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 28 Pages: 1120-1130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Brain-derived neurotrophic factor, corticotropin-releasing factor, and hypothalamic neuronal histamine interact to regulate feeding behavior.2013
- Author(s)
  Gotoh K, Masaki T, Chiba S, Ando H, Fujiwara K, Shimasaki T, Mitsutomi K, Katsuragi I, Kakuma T, Sakata T, Yoshimatsu H.
- Journal Title
  
  J Neurochem.
  
  Volume: 125 Pages: 588-598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity.2013
- Author(s)
  Shimasaki T, Masaki T, Mitsutomi K, Ueno D, Gotoh K, Chiba S, Kakuma T, Yoshimatsu H.
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0063626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Involvement of remnant spleen volume on the progression of steatohepatitis in diet-induced obese rats after a splenectomy.2012
- Author(s)
  Inoue M, Gotoh K, Seike M, Masaki T, Oribe J, Honda K, Kakuma T, Yoshimatsu H
- Journal Title
  
  Hepatology Research
  
  Volume: 42 Pages: 203-212
- NAID
  10031144227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] Role of spleen in the development of steatohepatitis in high-fat-diet-induced obese rats2012
- Author(s)
  Inoue M, Gotoh K, Seike M, Masaki T, Honda K, Kakuma T. Yoshimatsu H
- Journal Title
  
  Exp Biol Med
  
  Volume: 237 Pages: 461-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced hypothalamic inflammation.2012
- Author(s)
  Gotoh K, Inoue M, Masaki T, Chiba S, Shimasaki T, Ando H, Fujiwara K, Katsuragi I, Kakuma T, Seike M, Sakata T, Yoshimatsu H.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 120 Pages: 752-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] Involvement of remnant spleen volume on the progression of steatohepatitis in diet-induced obese rats after a splenectomy.2012
- Author(s)
  Inoue M, Gotoh K, Seike M, Masaki T, Oribe J, Honda K, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Hepatol Res.
  
  Volume: 42 Pages: 203-212
- DOI
  10.1111/j.1872-034x.2011.00914.x
- NAID
  10031144227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced inflammation in white adipose tissue and liver2012
- Author(s)
  Gotoh K, Inoue M, Masaki T, Chiba S, Shimasaki T, Ando H, Fujiwara K, Katsuragi I, Kakuma T, Seike M, Sakata T, Yoshimatsu H
- Journal Title
  
  Diabetes
  
  Volume: 61 Pages: 1994-2003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Involvement of remnant spleen volume on the progression of steatohepatitis in diet-induced obese rats after a splenectomy2012
- Author(s)
  Inoue M, Gotoh K, Seike M, Masaki T, Oribe J, Honda K, Kakuma T. Yoshimatsu H
- Journal Title
  
  Hepatol Res
  
  Volume: 42 Pages: 203-212
- NAID
  10031144227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced hypothalamic inflammation2012
- Author(s)
  Gotoh K, Inoue M, Masaki T, Chiba S, Shimasaki T, Ando H, Fujiwara K, Katsuragi I, Kakuma T, Seike M, Sakata T, Yoshimatsu H
- Journal Title
  
  J Neurochem
  
  Volume: 120 Pages: 752-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] A Novel Anti-Inflammatory Role for Spleen-Derived Interleukin-10 in Obesity-induced Inflammation in White Adipose Tissue and Liver2012
- Author(s)
  Gotoh K, Inoue M, Masaki T, Chiba S, Shimasaki T, Ando H, Fujiwara K, Katsuragi I, Kakuma T, Seike M, Sakata T, Yoshimatsu H.
- Journal Title
  
  Diabetes
  
  Volume: 61 Pages: 1994-2003
- DOI
  10.2337/db11-1688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Spleen-derived interleukin-10 downregulates the severity of high-fat diet-induced non-alcoholic Fatty pancreas disease2012
- Author(s)
  Gotoh K, Inoue M, Shiraishi K, Masaki T, Chiba S, Mitsutomi K, Shimasaki T, Ando H, Fujiwara K, Katsuragi I, Kakuma T, Seike M, Sakata T, Yoshimatsu H
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Intracerebroventricular administration of urotensin II regulates food intake and sympathetic nerve activity in brown adipose tissue.2012
- Author(s)
  Yasuda T, Masaki T, Gotoh K, Chiba S, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Peptides.
  
  Volume: 35 Pages: 131-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] Intraperitoneal administrartion attenuates thiazolidinedions-induced hepatic steatosis in KKAy mice with increased hepatic peroxisome proliferator-activated receptor (PPAR)γ mRNA expression2012
- Author(s)
  Oribe J, Kakuma T, Haranaka M, Okamoto K, Seike M, Yoshimatsu H
- Journal Title
  
  Obes Res Clin Prac
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Ghrelin in small intestine, its contribution to regulation of food intake and body weight in cross-intestinal parabiotic rats.2011
- Author(s)
  Noguchi H, Masaki T, Kakuma T, Nakazato M, Yoshimatsu H
- Journal Title
  
  Endocrine Journal
  
  Volume: 58 Pages: 625-632
- NAID
  10029589582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] Effects of Pravastatin on Obesity, Diabetes, and Adiponectin in Diet-induced Obese Mice2008
- Author(s)
  Araki K, Masaki T, Katsuragi I, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Obesity (Silver Spring)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Effects of pravastatin on obesity, diabetes, and adiponectin in diet-induced obese mice2008
- Author(s)
  Araki K, Masaki T, Katsuragi I, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Obesity (SilverSpring) 16(9)
  
  Pages: 2068-2073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice2007
- Author(s)
  Higuchi K, Masaki T, Gotoh K, Chiba S, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Endocrinology 148(6)
  
  Pages: 2690-2697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice2007
- Author(s)
  Higuchi K, Masaki T, Gotoh K, Chiba S, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Endocrinology 148
  
  Pages: 2690-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake2007
- Author(s)
  Gotoh K, Fukagawa K, Fukagawa T, Noguchi H, Kakuma T, Sakata T, Yoshimatsu H.
- Journal Title
  
  J Neurochem 103(3)
  
  Pages: 1102-1110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake2007
- Author(s)
  Gotoh K, Fukagawa K, Fukagawa T, Noguchi H, Kakuma T, Sakata T, Yoshimatsu H.
- Journal Title
  
  J Neurochem 103
  
  Pages: 1102-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Sterol regulatory element binding protein(SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes2006
- Author(s)
  Okamoto K, Kakuma T, Fukuchi S, Masaki T, Sakata T, Yoshimatsu H.
- Journal Title
  
  Brain Res. 1081(1)
  
  Pages: 19-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] Telmisartan prevents obesity and increases the expression of uncoupling protein 1 in diet-induced obese mice2006
- Author(s)
  Araki K, Masaki T, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Hypertension 48(1)
  
  Pages: 51-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury2005
- Author(s)
  Masaki T, Chiba S, Tatsukawa H, Noguchi H, Kakuma T, Endo M, Seike M, Watanabe T, Yoshimatsu H.
- Journal Title
  
  FASEB J. 19(10)
  
  Pages: 1245-1252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Presentation] 大学生世代の体重管理と生活習慣改善指導2021
- Author(s)
  加隈哲也
- Organizer
  第41回日本肥満学会/第38回日本肥満症治療学会学術集会教育講演
- Data Source
  KAKENHI-PROJECT-21K11625
[Presentation] 青年層の肥満症予防から、将来のメタボ診療を臨む2021
- Author(s)
  加隈哲也
- Organizer
  第59回日本糖尿病学会九州地方会シンポジウム
- Data Source
  KAKENHI-PROJECT-21K11625
[Presentation] やさしい消化器病（お腹の話）のお話 - 専門医が語る治療最前線 -「あなたは、良い肥満？悪い肥満？　ーメタボと消化器・肝臓病の熱い関係ー2021
- Author(s)
  加隈哲也
- Organizer
  第109回日本消化器病学会九州支部市民公開講座
- Data Source
  KAKENHI-PROJECT-21K11625
[Presentation] 大学生世代の生活背景に基づく食行動の特徴と体重増加に関与する因子の検討2021
- Author(s)
  加隈哲也、吉田雄一、岡本光弘、柴田洋孝、堤隆、工藤欣邦
- Organizer
  第59回全国大学保健管理研究集会
- Data Source
  KAKENHI-PROJECT-21K11625
[Presentation] 脳―脾連関からみた肥満による全身性慢性炎症の発症メカニズム2020
- Author(s)
  後藤孔郎，吉田雄一，尾関良則，野口貴昭、松田直樹、木下みずき、渋田可奈子、宮本昇太郎、穴井学，岡本光弘, 正木孝幸，加隈哲也，柴田洋孝孝
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K11605
[Presentation] 脳ー脾相関からみた肥満による全身性慢性炎症の発症メカニズム2020
- Author(s)
  後藤孔郎、吉田雄一、尾関良則、穴井学、岡本光弘、正木孝幸、加隈哲也、柴田洋孝
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K01855
[Presentation] 糖尿病抵抗性、肥満抵抗性、脂肪肝抵抗性マウスの腸内細菌叢と肝臓メタボローム解析2019
- Author(s)
  加隈哲也、藤原貫爲、酒井久美子、千葉政一、後藤孔郎、正木孝幸、柴田洋孝、吉村充弘、上田陽一
- Organizer
  第92回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K01855
[Presentation] 膵β細胞特異的TNFα過剰発現マウスは糖尿病抵抗性、肥満抵抗性、脂肪肝抵抗性を呈する2018
- Author(s)
  加隈哲也、藤原貫爲、安藤久恵、千葉政一、後藤孔郎、正木孝幸、柴田洋孝、吉村充弘、上田陽一
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K01855
[Presentation] グルカゴン分泌調節におけるGLP-1と脳由来神経栄養因子との関連2018
- Author(s)
  後藤孔郎、吉田雄一、尾関良則、岡本将英、岡本光弘、正木孝幸、加隈哲也、柴田洋孝
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17K01854
[Presentation] 肥満による代償性膵島過形成に対するGLP-1の中枢神経を介した改善作用2018
- Author(s)
  後藤孔郎、安藤久恵、吉田雄一、尾関良則、岡本将英、穴井学、岡本光弘、正木孝幸、加隈哲也、柴田洋孝
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K01854
[Presentation] 膵β細胞特異的TNFα過剰発現マウスは糖尿病抵抗性、肥満抵抗性、脂肪肝抵抗性を呈する2017
- Author(s)
  加隈哲也、藤原貫爲、安藤久恵、千葉政一、後藤孔郎、正木孝幸、柴田洋孝、吉村充弘、上田陽一
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17K01855
[Presentation] リラグルチドからリキシセナチドへの変更の有効性をアセトアミノフェン試験で確認し得た2 型糖尿病の一例2017
- Author(s)
  森優美，富本あけみ，岡本将英，岡本光弘，仲間寛，野口貴昭，福山光，後藤孔郎，正木孝幸，加隈哲也，柴田洋孝
- Organizer
  第60回日本糖尿病学会年次総会
- Data Source
  KAKENHI-PROJECT-26350896
[Presentation] 肥満「症」としての2型糖尿病ー最近の話題と課題ー2016
- Author(s)
  加隈哲也
- Organizer
  第54回日本糖尿病学会九州地方会
- Place of Presentation
  鹿児島
- Year and Date
  2016-10-14
- Invited
- Data Source
  KAKENHI-PROJECT-26350897
[Presentation] 肥満に伴う肝臓や内臓脂肪内の炎症性変化およびインスリン抵抗性における、脾臓由来IL-10の役割2015
- Author(s)
  後藤孔郎, 正木孝幸, 加隈哲也, 柴田洋孝
- Organizer
  第２回肝臓と糖尿病・代謝研究会
- Place of Presentation
  海峡メッセ下関（山口県下関市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-24500859
[Presentation] 肥満に伴う肝の脂肪化, 炎症性変化およびインスリン抵抗性における脾臓の役割2013
- Author(s)
  後藤孔郎, 井上恵, 白石賢太郎, 安藤久恵, 嶋崎貴信, 正木孝幸, 千葉政一, 藤原貫為, 清家正隆, 加隈哲也
- Organizer
  第86回日本内分泌学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23500846
[Presentation] 肥満に伴う非アルコール性脂肪性肝疾患(NAFLD)の発症における脾臓由来IL-10の役割2013
- Author(s)
  後藤孔郎, 正木孝幸, 千葉政一, 嶋崎貴信, 安藤久恵, 藤原貫為, 加隈哲也, 清家正隆, 柴田洋孝
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23500846
[Presentation] 2型糖尿病治療における血糖と体重の良好なコントロールの両立を目指して2013
- Author(s)
  加隈哲也
- Organizer
  第51回日本糖尿病学会九州地方会
- Place of Presentation
  那覇
- Data Source
  KAKENHI-PROJECT-23500846
[Presentation] 中枢性因子と食行動2013
- Author(s)
  加隈哲也
- Organizer
  第34回日本肥満学会(シンポジウム)
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-23500846
[Presentation] 肥満に伴う視床下部内の慢性炎症における脾臓由来IL-10の役割2012
- Author(s)
  後藤孔郎, 井上恵, 正木孝幸, 千葉政一, 嶋崎貴信, 安藤久恵, 藤原貫為, 葛城功, 加隈哲也, 清家正隆, 坂田利家, 吉松博信
- Organizer
  第55回日本糖尿病学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23500846
[Presentation] 肥満糖尿病マウスにおいてチアゾリジン誘導体による脂肪肝増悪の機序2008
- Author(s)
  織部淳哉、清家正隆、加隈哲也、原中美環、岡本健二郎、吉松博信
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  愛媛
- Data Source
  KAKENHI-PROJECT-19590779
[Presentation] 肥満糖尿病マウスにおけるチアゾリジン誘導体の肝臓、代謝への影響2007
- Author(s)
  織部淳哉、清家正隆、加隈哲也、荒川光江、遠藤美月、吉松博信
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590779
[Presentation] 糖尿病合併脂肪肝症例と非脂肪肝症例の予後の検討2007
- Author(s)
  織部淳哉、清家正隆、針里栄、井上恵、姫野克郎、高橋祐幸、加隈哲也、吉松博信
- Organizer
  第93回日本消化器病学会総会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-19590779
[Presentation] 肥満に伴う非アルコール性脂肪性膵疾患（NAFPD）における脾臓由来IL-10の役割
- Author(s)
  後藤孔郎, 正木孝幸, 加隈哲也, 柴田洋孝
- Organizer
  第58回日本糖尿病学会総会
- Place of Presentation
  海峡メッセ下関（山口県下関市）
- Year and Date
  2015-05-21 – 2015-05-23
- Data Source
  KAKENHI-PROJECT-24500859
[Presentation] 肥満に伴う非アルコール性脂肪性膵疾患（NAFPD）における脾臓由来IL-10の役割
- Author(s)
  後藤孔郎, 正木孝幸, 加隈哲也, 柴田洋孝
- Organizer
  第88回日本内分泌学会総会
- Place of Presentation
  ホテルニューオータニ東京（東京都千代田区）
- Year and Date
  2015-04-22 – 2015-04-24
- Data Source
  KAKENHI-PROJECT-24500859

1. TAKAYUKI MASAKI (00423715)

# of Collaborated Projects: 13 results

# of Collaborated Products: 38 results
2. GOTO Koro (10457624)

# of Collaborated Projects: 11 results

# of Collaborated Products: 25 results
3. YOSHIMATSU Hironobu (00166993)

# of Collaborated Projects: 8 results

# of Collaborated Products: 28 results
4. 柴田洋孝 (20245484)

# of Collaborated Projects: 7 results

# of Collaborated Products: 14 results
5. SEIKE Masataka (40253794)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
6. CHIBA Seiichi (20457633)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
7. 岡本光弘 (80774546)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. HAMAGUCHI Kazuyuki (60180931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. INA Keisuke (20203193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. WAKANA Sigeharu (90192434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 坂田利家 (50037420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 植田聡 (00624511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KAKUMA TETSUYA 加隈 哲也

KAKUMA Tetsuya 加隈 哲也

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食育を目指した保健指導への挑戦：行動療法的方法論に基づいた糖尿病前症の対策Principal Investigator

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過栄養性脂肪肝発症における膵臓―脳―肝臓の臓器間ネットワークと腸内細菌叢の関与Principal Investigator

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The approach for pathogenic mechanism of Type 1 diabetes using transgenic mice expressing TNFalpha selectively in pancreatic beta cellsPrincipal Investigator

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The clarification of pathophysiological mechanism for over-nutritional fatty liver and the involvement of DNA damage by oxygen radicalPrincipal Investigator

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Isolation of physiologically active substance regarding the pathogenesis and development of fatty liver under overeatingPrincipal Investigator

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KAKUMA TETSUYA 加隈哲也

KAKUMA Tetsuya 加隈哲也