KOJIMA KATSUHIKO 小嶋克彦

… Alternative Names

Kojima Katsuhiko 小嶋克彦

KOJIMA Katsuhiko 小嶋克彦

小嶋克彦コジマカツヒコ

Less

Researcher Number	80345743
Other IDs
Affiliation (Current)	2025: 信州大学, 学術研究院医学系, 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 信州大学, 学術研究院医学系, 講師 2015: 信州大学, 学術研究院医学系, 講師 2011 – 2014: 信州大学, 医学部, 助教 2004 – 2005: 信州大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Functional biochemistry Except Principal Investigator General physiology / Pediatrics / Human pathology / Immunology
Keywords	Principal Investigator 細胞骨格 / 転移 / 胆管癌 / S100A10 / 細胞遊走 / 腫瘍微小環境 / VHH抗体 / ナノボディ / 転移浸潤 / 癌幹細胞 … More / 細胞周期 / S100 protein / 細胞浸潤 / 細胞膜レセプター / 細胞内小胞輸送 / プロテアーゼ / ユビキチン / エンドソーム … More Except Principal Investigator 小胞輸送シグナル / ユビキチン / サイトカイン受容体 / 小胞輸送 / ユビキチン非依存性小胞輸送 / インターロイキン４受容体 / インターロイキン２受容体 / 受容体遺伝子多型 / アレルギー / サイトカイン / 炎症性腸疾患 / 粘膜免疫 / 発現クローニング / M細胞 / エンドソーム Less

S100A10を標的とした抗腫瘍VHH抗体による胆管癌治療法の開発Principal Investigator
- Principal Investigator
  
  小嶋克彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shinshu University
Functional elucidation of S100A10 in the acquisition of invasive and metastatic abilities of cholangiocarcinoma and its development into therapeutic strategiesPrincipal Investigator
- Principal Investigator
  
  Kojima Katsuhiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shinshu University
Functional role of S100 proteins in maintenance of the malignant phenotype in cancer stem cells of cholangiocarcinomaPrincipal Investigator
- Principal Investigator
  
  Kojima Katsuhiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shinshu University
Endosomal sorting signal of cytokine receptors and its single nucleotide polymorphism in allergy disease
- Principal Investigator
  
  TAKESHITA Toshikazu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Ubiquitin-independent endosomal sorting of cytokine receptors
- Principal Investigator
  
  AMANO Yuji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University
Expression cloning of the gene functioning in transformation of Caco-2 cells to M cells
- Principal Investigator
  
  KOBAYASHI Motohiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  University of Fukui
  Shinshu University
Identification of ubiquitin-dependent endosomal sorting signal in cytokine receptors
- Principal Investigator
  
  TAKESHITA Toshikazu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Shinshu University
脱ユビキチン化酵素AMSHによる細胞内小胞輸送の制御機構の解析Principal Investigator
- Principal Investigator
  
  小嶋克彦
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Shinshu University

All 2022 2021 2020 2019 2018 2014 2011 2010 2009

All Journal Article Presentation

[Journal Article] MK‐6, a novel not‐α IL‐2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance2021
- Author(s)
  Kobayashi Maki、Kojima Katsuhiko、Murayama Kazutaka、Amano Yuji、Koyama Takashi、Ogama Naoko、Takeshita Toshikazu、Fukuhara Tatsuro、Tanaka Nobuyuki
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 11 Pages: 4478-4489
- DOI
  10.1111/cas.15127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08203, KAKENHI-PROJECT-20K08580, KAKENHI-PROJECT-21K08795
[Journal Article] ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation2014
- Author(s)
  Kojima, K., Amano, Y., Yoshino, K., Tanaka, N., Sugamura, K., Takeshita, T.
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 48 Pages: 33296-33310
- DOI
  10.1074/jbc.m114.578245
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-25461586, KAKENHI-PROJECT-25860161
[Journal Article] Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting2011
- Author(s)
  Amano Y, Yamashita Y, Tanaka N, Sugamura K, 他
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 17 Pages: 15458-15472
- DOI
  10.1074/jbc.m110.191924
- NAID
  120007110518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590517, KAKENHI-PROJECT-21590530, KAKENHI-PROJECT-22591925
[Presentation] Tyro3-Gas6およびTyro3-Protein S複合体は、リン脂質結合によりCD63陽性エクソソームを細胞内に取り込む2022
- Author(s)
  小山昂志、小嶋克彦、前田昂樹、竹下敏一、森田英嗣、田中伸幸
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K08795
[Presentation] TYRO3はGAS6を介してフォスファチジルセリンに結合することでエクソソームを取り込む2022
- Author(s)
  小山昂志、小嶋克彦、前田昂樹、竹下敏一、森田英嗣、田中伸幸
- Organizer
  第9回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08795
[Presentation] A novel non-a IL-2 elicits potent anti-tumor activity in mice by improving the effector to regulatory T cell balance2021
- Author(s)
  Maki Kobayashi, Naoko Ogama, Katsuhiko Kojima, Tatsuro Fukuhara, Nobuyuki Tanaka
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08795
[Presentation] S100A10 regulates proliferation and migration of HNSCC cells through cytoskeleton control2021
- Author(s)
  Naoko Ogama, Katsuhiko Kojima, Nobuyuki Tanaka
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08795
[Presentation] IL-2受容体a鎖結合性を喪失させた新規IL-2はエフェクター/制御性T細胞バランスを改善することで抗腫瘍活性を発揮する2020
- Author(s)
  小林真紀、小鎌直子、小嶋克彦、福原達朗、田中伸幸
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08643
[Presentation] S100A10 regulates proliferation and migration of HNSCC cells through cytoskeleton control2019
- Author(s)
  Naoko Ogama, Katsuhiko Kojima, Takayuki Imai, Maki Kobayashi, Kazuto Matsuura,　Nobuyuki Tanaka
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08643
[Presentation] S100A10 regulates malignant phenotypes of head and neck squamous cell cancer.2018
- Author(s)
  Nishikawaji T, Kojima K, Ogama N, Matsuura K, Tanaka N
- Organizer
  第７７回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08643
[Presentation] Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting2011
- Author(s)
  天野勇治、小嶋克彦、吉野和寿、竹下敏一
- Organizer
  日本免疫学会
- Place of Presentation
  千葉
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] Identification of Hrs-binding motif in the cytokine receptors delivered to lysosome in ubiquitin-independent manner2010
- Author(s)
  天野勇治、小嶋克彦、山下勇毅、吉野和寿、竹下敏一
- Organizer
  国際免疫学会
- Place of Presentation
  神戸
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] Identification of Hrs-binding motif in the cytokine receptors delivered to lysosome in ubiquitin-independent manner2010
- Author(s)
  天野勇治、小嶋克彦、山下勇毅、吉野和寿、竹下敏一
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] ユビキチン非依存的に小胞輸送されるサイトカイン受容体のHrs会合モチーフの同定2009
- Author(s)
  天野勇治、小嶋克彦、山下勇毅、吉野和寿、竹下敏一
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] 細胞内小胞輸送と細胞増殖におけるIL-2受容体β鎖のHrs結合領域の役割2009
- Author(s)
  山下勇毅、小嶋克彦、天野勇治、吉野和寿、竹下敏一
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590530

1. TAKESHITA Toshikazu (60212023)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. YOSHINO Kazuhisa (40551859)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. AMANO Yuji (50624681)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. KOBAYASHI Motohiro (00362137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 菅村和夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 田中伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

KOJIMA KATSUHIKO 小嶋 克彦

Kojima Katsuhiko 小嶋 克彦

KOJIMA Katsuhiko 小嶋 克彦

小嶋 克彦 コジマ カツヒコ

Research Projects

Research Products

Co-Researchers

S100A10を標的とした抗腫瘍VHH抗体による胆管癌治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional elucidation of S100A10 in the acquisition of invasive and metastatic abilities of cholangiocarcinoma and its development into therapeutic strategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional role of S100 proteins in maintenance of the malignant phenotype in cancer stem cells of cholangiocarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Endosomal sorting signal of cytokine receptors and its single nucleotide polymorphism in allergy disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ubiquitin-independent endosomal sorting of cytokine receptors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression cloning of the gene functioning in transformation of Caco-2 cells to M cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of ubiquitin-dependent endosomal sorting signal in cytokine receptors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脱ユビキチン化酵素AMSHによる細胞内小胞輸送の制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] MK‐6, a novel not‐α IL‐2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Tyro3-Gas6およびTyro3-Protein S複合体は、リン脂質結合によりCD63陽性エクソソームを細胞内に取り込む2022

Author(s)

Organizer

Data Source

[Presentation] TYRO3はGAS6を介してフォスファチジルセリンに結合することでエクソソームを取り込む2022

Author(s)

Organizer

Data Source

[Presentation] A novel non-a IL-2 elicits potent anti-tumor activity in mice by improving the effector to regulatory T cell balance2021

KOJIMA KATSUHIKO 小嶋克彦

Kojima Katsuhiko 小嶋克彦

KOJIMA Katsuhiko 小嶋克彦

小嶋克彦コジマカツヒコ