INOUE Takehiko 井上岳彦

Researcher Number	80346361
Affiliation (based on the past Project Information) *help	2010: 鳥取大学, 医学部・附属病院, 助教 2005 – 2006: 鳥取大学, 医学部附属病院, 助手 2005: 鳥取大学, 医学部付属病院, 助手 2004: TOTTORI UNIVERSITY, INSTITUTE OF NEUROLOGICAL SCIENCES, ASSISTANT PROFESSOR, 医学部附属病院, 助手 2003: 鳥取大学, 医学部付属病院, 助手 2003: 鳥取大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Pediatrics Except Principal Investigator Pediatrics / Pediatrics
Keywords	Principal Investigator サイトカイン / ゴーシェ病 Except Principal Investigator ゴーシェ病 / Gaucher disease / ライソゾーム病 / 分子シャペロン療法 / 分子シャペロン / リソゾーム / glia / IL-6 … More / Toll-like receptor / cholesterol / Niemann-Pick disease C / N-octyl-β-valienamine / Chemical chaperone therapy / βグルコシダーゼ / 酵素蛋白質の安定化 / ニーマンピック病 / ニーマン・ピック病 / 小児 / 遺伝病 / 変異酵素活性化療法 / ニーマン・ピック病C型 / Lysosome / Carba-sugar / Low molecular compound / Therapy / 先天代謝異常 / β-グルコセレブロシダーゼ / ライソゾーム / カルバ糖誘導体 / 低分子物質 / 治療 / モデルマウス / 経口治療薬 / シャペロン Less

Basic research for clinical treatment of neuropathic Gaucher disease by chemical chhaperones
- Principal Investigator
  
  OHNO Kousaku
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
Establishment of new therapeutic strategies for neurogenetic disorders during childhood
- Principal Investigator
  
  OHNO Kousaku
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
ゴーシェ病における細胞障害への免疫の関与の検討および新しい治療法の開発Principal Investigator
- Principal Investigator
  
  井上岳彦
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
THE RESEARCH OF THE THERAPY FOR GAUCHER DISEASE WITH CENTRAL NERVOUS INVOLVEMENT BY THE LOW MOLECULAR COMPOUNDS.
- Principal Investigator
  
  NANBA Eiji, 岡明
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University

All 2007 2006 2004

All Journal Article

[Journal Article] Enzyme enhancement activity of N-octyl-beta-valienamine on beta-glucosidase mutants associated with Gaucher disease.2007
- Author(s)
  Lei K, Ninomiya H, Suzuki M, Inoue T, Sawa M, Iida M, Ida H, Eto Y, Ogawa S, Ohno K, Suzuki Y
- Journal Title
  
  Biochim Biophys Acta 1772
  
  Pages: 587-596
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Enzyme enhancement activity of N-octyl-beta-valienamine on beta-glucosidase mutants associated with Gaucher disease.2007
- Author(s)
  Lei K, Ninomiya H, Suzuki M, Inoue T, Sawa M, Iida M, Ida H, Eto Y, Ogawa S, Ohno K, Suzuki Y.
- Journal Title
  
  Biochim Biophys Acta. 1772
  
  Pages: 587-96
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24- amidated conjugates of 3β,7β-dihydroxy-5-cholen-24-oic acid, and related compounds : Unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1.2006
- Author(s)
  Iida T, Kakiyama G, Hibiya Y, Miyata S, Inoue T, Ohno K, Goto T, Mano N, Goto J, Nambara T, A F Hofmann
- Journal Title
  
  Steroids 71
  
  Pages: 18-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3β,7β-dihydroxy-5-cholen-24-oic acid, and related compounds : Unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1.2006
- Author(s)
  Iida T, Kakiyama G, Hibiya Y, Miyata S, Inoue T, Ohno K, Goto T, Mano N, Goto J, Nambara T, A F Hofmann.
- Journal Title
  
  Steroids 71
  
  Pages: 18-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease.2004
- Author(s)
  Lin H, Sugimoto Y, Ohsaki Y, Ninomiya H, Oka A, Taniguchi M, Ida H, Eto Y, Ogawa S, Matsuzaki Y, Sawa M, Inoue T, Higaki K, Nanba E, Ohno K, Suzuki Y
- Journal Title
  
  Biochim Biophys Acta 1689
  
  Pages: 219-228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease.2004
- Author(s)
  Lin H, Sugimoto Y, Ohsaki Y, Ninomiya H, Oka A, Taniguchi M, Ida H, Eto Y, Ogawa S, Matsuzaki Y, Sawa M, Inoue T, Higaki K, Nanba E, Ohno K, Suzuki Y.
- Journal Title
  
  Biochimica et Biophysica Acta 1689
  
  Pages: 219-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570746
[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease.2004
- Author(s)
  Lin H, Sugimoto Y, Ohsaki Y, Ninomiya H, Oka A, Taniguchi M, Ida H, Eto Y, Ogawa S, Matsuzaki Y, Sawa M, Inoue T, Higaki K, Nanba E, Ohno K, Suzuki Y.
- Journal Title
  
  Biochim Biophys Acta. 1689
  
  Pages: 219-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302

1. OHNO Kousaku (70112109)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. NANBA Eiji (40237631)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. SUGIURA Titose (90325027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NINOMIYA Haruaki (80212124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 岡明 (00251273)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 赤星進二郎 (90231810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

INOUE Takehiko 井上 岳彦

Research Projects

Research Products

Co-Researchers

Basic research for clinical treatment of neuropathic Gaucher disease by chemical chhaperones

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of new therapeutic strategies for neurogenetic disorders during childhood

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゴーシェ病における細胞障害への免疫の関与の検討および新しい治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE RESEARCH OF THE THERAPY FOR GAUCHER DISEASE WITH CENTRAL NERVOUS INVOLVEMENT BY THE LOW MOLECULAR COMPOUNDS.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Enzyme enhancement activity of N-octyl-beta-valienamine on beta-glucosidase mutants associated with Gaucher disease.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Enzyme enhancement activity of N-octyl-beta-valienamine on beta-glucosidase mutants associated with Gaucher disease.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24- amidated conjugates of 3β,7β-dihydroxy-5-cholen-24-oic acid, and related compounds : Unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3β,7β-dihydroxy-5-cholen-24-oic acid, and related compounds : Unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease.2004

Author(s)

Journal Title

Description

Data Source

INOUE Takehiko 井上岳彦