Atsumi Toru 熱海徹

… Alternative Names

熱海徹アツミトオル

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Researcher Number	80360478
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2015 – 2016: 北海道大学, 遺伝子病制御研究所, 特任助教 2014: 北海道大学, 遺伝子病制御研究所, 研究員 2004: 独立行政法人理化学研究所, サイトカイン制御研究グループ, 研究員 2003: 独立行政法人理化学研究所, サイトカインシステム情報制御研究チーム, 研究員
Review Section/Research Field	Principal Investigator Immunology / Experimental pathology
Keywords	Principal Investigator スプライシング / エピジェネティクス / 選択性スプライシング / 選択的スプライシング / DNAメチル化 / 炎症 / 樹状細胞 / SEB / AICD / gp130 / IL-6

Rbm10 regulates inflammation development via alternative splicing of Dnmt3b, a DNA methyltransferasePrincipal Investigator
- Principal Investigator
  
  Atsumi Toru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
AICDにおけるIL-6依存性Fasリガンド発現抑制効果の機構解析Principal Investigator
- Principal Investigator
  
  熱海徹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  The Institute of Physical and Chemical Research

All 2016 2015 2014 2004 2003 Other

All Journal Article Presentation

[Journal Article] Breakpoint cluster region-mediated inflammation is dependent on casein kinase II.2016
- Author(s)
  Meng, J., J-J Jiang, T. Atsumi, H. Bando, Y. Okuyama, L. Sabharwal, I. Nakagawa, H. Higuchi, M. Ota, M. Okawara, R. Ishitani, O. Nureki, D. Higo, Y. Arima, H. Ogura, D. Kamimura and M. Murakami.
- Journal Title
  
  J Immunol.
  
  Volume: 197(8) Issue: 8 Pages: 3111-3119
- DOI
  10.4049/jimmunol.1601082
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04741, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-26460574, KAKENHI-PROJECT-15K15147, KAKENHI-PROJECT-15K19122
[Journal Article] Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.2016
- Author(s)
  Kamimura, D. Y. Arima, M. Tsuruoka, J-J Jiang, H. Bando, J. Meng, L. Sabharwal, A. Stofkova, N. Nishikawa, K. Higuchi, H. Ogura, T. Atsumi, M. Murakami.
- Journal Title
  
  Int Immunol.
  
  Volume: 28(3) Issue: 3 Pages: 117-126
- DOI
  10.1093/intimm/dxv059
- NAID
  120005851045
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15147, KAKENHI-PROJECT-15H04741, KAKENHI-PROJECT-14F04789, KAKENHI-PROJECT-26460574, KAKENHI-PROJECT-15K19122, KAKENHI-PROJECT-15K08518
[Journal Article] Control of chronic inflammation by the inflammation amplifier and gateway reflexes.2016
- Author(s)
  Ota, M., D. Kamimura, I. Nakagawa, H. Higuchi, Y. Tanaka, M. Fujita, S. Hiratsuka, M. Okawara, K. Murakami, T. Atsumi, Y. Arima and M. Murakami.
- Journal Title
  
  Advances in Medicine and Biology
  
  Volume: 104 Pages: 65-86
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460574
[Journal Article] Immune Cell Gateways in the CNS Regulated by Regional Neural Stimulations.2015
- Author(s)
  Kamimura, D., A. Stofkova, N. Nishikawa, T. Atsumi, Y. Arima, M. Murakami.
- Journal Title
  
  Clin Exp Neuroimmunol.
  
  Volume: 印刷中 Issue: 2 Pages: 120-128
- DOI
  10.1111/cen3.12198
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24659221, KAKENHI-PROJECT-26460574, KAKENHI-PROJECT-15K19122, KAKENHI-PROJECT-15H04741, KAKENHI-PROJECT-14F04789
[Journal Article] Temporal expression of growth factors triggered by epiregulin regulates inflammation development.2015
- Author(s)
  Harada, M., Kamimura, D., Arima, Y., Kohsaka, H., Nakatsuji, Y., Nishida, M., Atsumi, T., Meng, J., Bando, H., Singh, R., Sabharwal, L., Jiang, J. J., Kumai, N., Miyasaka, N., Sakoda, S., Yamauchi-Takihara, K., Ogura, H., Hirano, T. & Murakami, M.
- Journal Title
  
  J Immunol
  
  Volume: 194 Issue: 3 Pages: 1039-1046
- DOI
  10.4049/jimmunol.1400562
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14F04789, KAKENHI-PROJECT-24249028, KAKENHI-PROJECT-24390098, KAKENHI-PROJECT-24500854, KAKENHI-PROJECT-24590583, KAKENHI-PROJECT-24659221, KAKENHI-PROJECT-26460574, KAKENHI-PROJECT-15K01712
[Journal Article] The reverse-direction method links mass experimental data to human diseases.2014
- Author(s)
  Ogura, H., Atsumi, T., Bando, H., Sabharwal, L., Yamada, M., Jiang, J. J., Nakamura, A., Arima, Y., Kamimura, D. & Murakami, M
- Journal Title
  
  Archivum immunologiae et therapiae experimentalis
  
  Volume: 62 Issue: 1 Pages: 41-45
- DOI
  10.1007/s00005-013-0255-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14F04789, KAKENHI-PROJECT-24249028, KAKENHI-PROJECT-24390098, KAKENHI-PROJECT-24590583, KAKENHI-PROJECT-24790472, KAKENHI-PROJECT-26460574
[Journal Article] Inflammation Amplifier, a New Paradigm in Cancer Biology2014
- Author(s)
  Atsumi T, Singh R, et al.
- Journal Title
  
  Cancer Research
  
  Volume: 74 Issue: 1 Pages: 8-14
- DOI
  10.1158/0008-5472.can-13-2322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00819, KAKENHI-PROJECT-14F04789, KAKENHI-PROJECT-24249028, KAKENHI-PROJECT-24390098, KAKENHI-PROJECT-24790472, KAKENHI-PROJECT-26460574
[Journal Article] The Gateway Reflex, which is mediated by the inflammation amplifier, directs pathogenic immune cells into the CNS.2014
- Author(s)
  Sabharwal, L., Kamimura, D., Meng, J., Bando, H., Ogura, H., Nakayama, C., Jiang, J. J., Kumai, N., Suzuki, H., Atsumi, T., Arima, Y. & Murakami, M.
- Journal Title
  
  Journal of biochemistry
  
  Volume: 156 Issue: 6 Pages: 299-304
- DOI
  10.1093/jb/mvu057
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14F04789, KAKENHI-PROJECT-24390098, KAKENHI-PROJECT-24590583, KAKENHI-PROJECT-24659221, KAKENHI-PROJECT-26460574, KAKENHI-PROJECT-26460575
[Journal Article] シグナル伝達異常と関節炎2004
- Author(s)
  熱海徹
- Journal Title
  
  現代医療
  
  Pages: 176-176
- Data Source
  KAKENHI-PROJECT-15790208
[Journal Article] IL-6レセプターgp130の異常と自己免疫病2003
- Author(s)
  熱海徹
- Journal Title
  
  臨床免疫
  
  Pages: 115-115
- Data Source
  KAKENHI-PROJECT-15790208
[Presentation] Serum components mediate inflammation in the joints in a mouse model of reactive arthritis2016
- Author(s)
  Toru Atsumi, Abhishek Kumar Singh, Daisuke Kamimura, Yasunobu Arima, Takuto Ohki, Yukihiro Sakashita, Naoki Nishikawa, Kotaro Higuchi, Ramnath Misra and Masaaki Murakami
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄県宜野湾市
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26460574
[Presentation] 非免疫細胞における炎症増幅機構（炎症回路）制御遺伝子NPK1の機能解析2016
- Author(s)
  Toru Atsumi, Hideki Ogura, Jie Meng, Hidenori Bando, Lavannya Sabharwal, Jing-jing Jiang, Chiemi Nakayama, Yasunobu Arima, Daisuke Kamimura and Masaaki Murakami
- Organizer
  第59回日本リウマチ学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26460574
[Presentation] 炎症回路制御遺伝子ZnXはDNAメチル化酵素Dnmt3bの活性を調節することにより、標的遺伝子のプロモーター部位におけるクロマチン構造を制御する。2015
- Author(s)
  熱海　徹、孟　潔、板東　英典、Sabharwal Lavannya、Jiang Jing-Jing、有馬　康伸、上村　大輔、小原　收、村上　正晃
- Organizer
  第80回日本サイトカイン、インターフェロン学会
- Place of Presentation
  東京工業大学（東京都目黒区）
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-26460574
[Presentation] Inflammation amplifier regulatory molecule NSZ1 controls NFkB specific chromatin accessibility via alternative splicing of a DNA methyltransferase2015
- Author(s)
  Toru Atsumi, Jie Meng, Hidenori Bando, Lavannya Sabharwal, Jing-Jing Jiang, Yasunobu Arima, Daisuke Kamimura, Koichi Nakajima, Osamu Ohara and Masaaki Murakami
- Organizer
  第44回日本免疫学会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26460574
[Presentation] 炎症アンプ制御遺伝子ZnXはNfkbと相互作用し、プロモーター.領域におけるクロマチン構造を制御する
- Author(s)
  Toru Atsumi, Kokichi Katsunuma, Hironao Suzuki, Hidenori Bando, Jie Meng, Lavannya Sabharwal, Hideki Ogura and Masaaki Murakami
- Organizer
  第8回日本エピジェネティクス研究年会
- Place of Presentation
  伊藤国際学術研究センター（東京都文京区）
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-26460574
[Presentation] Genes responsible for inflammation also strongly correlate with human cancer development
- Author(s)
  Toru Atsumi, Hideki Ogura, Jie Meng, Hidenori Bando, Lavannya Sabharwal, Jing-jing Jiang, Yasunobu Arima, Daisuke Kamimura and Masaaki Murakami
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26460574

1. 上村大輔 (20391922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 村上正晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results

Atsumi Toru 熱海 徹

熱海 徹 アツミ トオル

Research Projects

Research Products

Co-Researchers

Rbm10 regulates inflammation development via alternative splicing of Dnmt3b, a DNA methyltransferasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

AICDにおけるIL-6依存性Fasリガンド発現抑制効果の機構解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Breakpoint cluster region-mediated inflammation is dependent on casein kinase II.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Control of chronic inflammation by the inflammation amplifier and gateway reflexes.2016

Author(s)

Journal Title

Data Source

[Journal Article] Immune Cell Gateways in the CNS Regulated by Regional Neural Stimulations.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Temporal expression of growth factors triggered by epiregulin regulates inflammation development.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The reverse-direction method links mass experimental data to human diseases.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inflammation Amplifier, a New Paradigm in Cancer Biology2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Gateway Reflex, which is mediated by the inflammation amplifier, directs pathogenic immune cells into the CNS.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] シグナル伝達異常と関節炎2004

Author(s)

Journal Title

Data Source

[Journal Article] IL-6レセプターgp130の異常と自己免疫病2003

Author(s)

Journal Title

Data Source

[Presentation] Serum components mediate inflammation in the joints in a mouse model of reactive arthritis2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 非免疫細胞における炎症増幅機構（炎症回路）制御遺伝子NPK1の機能解析2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 炎症回路制御遺伝子ZnXはDNAメチル化酵素Dnmt3bの活性を調節することにより、標的遺伝子のプロモーター部位におけるクロマチン構造を制御する。2015

Author(s)

Organizer

Atsumi Toru 熱海徹

熱海徹アツミトオル