KAWAMICHI Hozumo 川道穂津美

Researcher Number	80363042
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007 – 2012: Yamaguchi University, Grad. School of Med., Dept. of Mol. Physiol, Assistant Professor 2010 – 2011: Yamaguchi University, 医学(系)研究科(研究院), 助教 2006: 山口大学, 大学院・医学系研究科, 助手 2006: 山口大学, 大学院医学系研究科, 助手 2005: 山口大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Neurophysiology and muscle physiology / Neurophysiology and muscle physiology Except Principal Investigator Neurophysiology and muscle physiology / Neurophysiology and muscle physiology / General physiology
Keywords	Principal Investigator 生体分子 / ナノシステム / 一分子 / 平滑筋 / 血管攣縮 / リアルタイム / 可視化 / 平滑筋生理 / 蛋白質 / 循環器・高血圧 / プロテオーム / タクパク質 / 生理学 … More Except Principal Investigator … More 質量分析 / 機能的プロテオミクス / シグナル伝達 / Functional Proteomics / Signal Transduction / Membrane Raft / Mass Spectrometry / Vascular Smooth Muscle / 膜ラフト / 血管 / 細胞骨格 / プロテオミクス / 平滑筋収縮 / 血管平滑筋 / 平滑筋生理 / 1分子 / 血管病 / 病態生理 Less

The elucidation of the relationship between vascular smooth muscle contraction and cytoskeletal rearrangement by proteomics and functional analysis
- Principal Investigator
  
  KISHI Hiroko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Yamaguchi University
血管攣縮の病的シグナル分子機能を時空間リアルタイム可視化観察するシステムの開発Principal Investigator
- Principal Investigator
  
  川道穂津美
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Yamaguchi University
Clarification of molecular mechanisms of abnormal vascular contraction by functional proteomics and a single molecular analysis of signal transduction
- Principal Investigator
  
  KOBAYASHI Sei
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Yamaguchi University
Clarification of vasospasm by a spatiotemporal nanoscale analysis of signal molecules.Principal Investigator
- Principal Investigator
  
  KAWAMICHI Hozumi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Yamaguchi University
血管平滑筋の異常収縮シグナル伝達の可視化による解明と創薬スクリーニングPrincipal Investigator
- Principal Investigator
  
  川道穂津美
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Yamaguchi University
Functional roles of membrane domain and its localized component proteins in abnormal vascular contraction
- Principal Investigator
  
  KOBAYASHI Sei
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Yamaguchi University

All 2012 2010 2009 2008 2007 2006

All Journal Article Presentation Patent

[Journal Article] Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts2012
- Author(s)
  Dan xu
- Journal Title
  
  Cellular Signaling
  
  Volume: 24 Issue: 1 Pages: 282-289
- DOI
  10.1016/j.cellsig.2011.09.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04493, KAKENHI-PROJECT-22500364, KAKENHI-PROJECT-22580131, KAKENHI-PROJECT-23380077, KAKENHI-PROJECT-23659113
[Journal Article] Focused proteomic approach to identify novel signaling molecules for abnormal vascular smooth muscle contraction2010
- Author(s)
  Hiroko Kishi, Shoko Nakajima, Hozumi Kawamichi, Katsuko Kajiya, Yuichi Takada, Daisuke Tokumori, Sei Kobayashi
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 60(Supplement 1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500364
[Journal Article] Focused Proteomicsによる、血管平滑筋異常収縮の新規病的シグナル分子の探索2010
- Author(s)
  岸博子、中島彰子、川道穂津美、加治屋勝子、王晨、高田雄一、小林誠
- Journal Title
  
  日本平滑筋学会雑誌
  
  Volume: 14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500364
[Journal Article] 日薬理誌2009
- Author(s)
  川道穂津美、岸博子、加治屋勝子、高田雄一、小林誠
- Journal Title
  
  血管異常収縮の分子機構と分子標的治療薬の探索 133
  
  Pages: 124-129
- Data Source
  KAKENHI-PROJECT-20700359
[Journal Article] 血管異常収縮の分子機構と分子標的治療薬の探索2009
- Author(s)
  川道穂津美
- Journal Title
  
  日薬理誌 133
  
  Pages: 124-129
- NAID
  10025740121
- Data Source
  KAKENHI-PROJECT-20700359
[Journal Article] 血管異常収縮の分子機構と分子標的治療薬の探索2009
- Author(s)
  川道穂津美, ら
- Journal Title
  
  日薬理誌 133巻
  
  Pages: 124-129
- NAID
  10025740121
- Data Source
  KAKENHI-PROJECT-20390059
[Journal Article] 血管異常収縮の分子機構と分子標的治療薬の探索2009
- Author(s)
  川道穂津美ら
- Journal Title
  
  日薬理誌 133
  
  Pages: 124-129
- NAID
  10025740121
- Data Source
  KAKENHI-PROJECT-20390059
[Journal Article] Time Studies2008
- Author(s)
  Hozumi Kawamichi.
- Journal Title
  
  Watching the motion pictures of signal molecules of the abnormal vascular contraction! Spatiotemporal nanoscale analysis of intracellular abnormality. 2
  
  Pages: 45-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700359
[Journal Article] Watching the motion pictures off signal molecules of the abnormal vascular contraction! Spatiotemporal nanoscale analysis of intracellular abnormality2008
- Author(s)
  Hozumi Kawamichi
- Journal Title
  
  Time Studies 2
  
  Pages: 45-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700359
[Journal Article] The involvement of Fyn tyrosine kinase and an in vitro assay to visualize the downstream signaling molecules of signal pathway in abnormal contraction of vascular smooth muscle induced by sphingosylphosphorylcholine.2007
- Author(s)
  H.Kawamichim et al.
- Journal Title
  
  The Journal of Physiological Sciences 57
- NAID
  130005448875
- Data Source
  KAKENHI-PROJECT-18700391
[Journal Article] Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts2007
- Author(s)
  Xu, D., Kishi, H., Kawamichi, H., Kajiya, K., Takada, Y., Kobayashi, S
- Journal Title
  
  FEBS Lett 581(peer-reviewed)
  
  Pages: 5227-5233
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300128
[Journal Article] Calcium inhibition of Physarum myosin as examined by the recombinant heavy mero-myosin2006
- Author(s)
  H.Kawamichim et al.
- Journal Title
  
  Regulatory mechanisms of striated muscle contraction
  
  Pages: 257-264
- Data Source
  KAKENHI-PROJECT-18700391
[Journal Article] The involvement of Fyn in Ca^<2+>-sensitization of vascular smooth muscle contraction.2006
- Author(s)
  H.Kawamichim et al.
- Journal Title
  
  SEIBUTSU BUTSURI 46
- Data Source
  KAKENHI-PROJECT-18700391
[Patent] 組換えミオシン2009
- Inventor(s)
  川道穂津美
- Industrial Property Rights Holder
  川道穂津美
- Filing Date
  2009-09-04
- Acquisition Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-20700359
[Patent] 組換えミオシン2009
- Inventor(s)
  小濱一弘、中村彰男、川道穂津美、田中秀幸
- Industrial Property Rights Holder
  群馬大学
- Filing Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] 平滑筋ミオシンはROKによってカルシウム非存在下で、直接リン酸化され、滑り運動を最大速度で引き起こすことが出来る.2009
- Author(s)
  川道穂津美
- Organizer
  第51回日本平滑筋学会
- Place of Presentation
  名古屋市立大学
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] 血管異常収縮の原因分子の動きを観察する!～時空間的ナノシステムによるリアルタイム可視化解析～2009
- Author(s)
  川道穂津美
- Organizer
  日本時間学会第1回大会
- Place of Presentation
  山口大学
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] 血管異常収縮の原因分子の動きを観察する!～時空間的ナノシステムによるリアルタイム可視化解析～2009
- Author(s)
  川道穂津美
- Organizer
  日本時間学会第1回大会
- Place of Presentation
  山口大学(山口県)
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] 平滑筋ミオシンはROKによってカルシウム非存在下で、直接リン酸化され、滑り運動を最大速度で引き起こすことが出来る2009
- Author(s)
  川道穂津美
- Organizer
  第51回日本平滑筋学会
- Place of Presentation
  名古屋市立大学(愛知県)
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] Rhoキナーゼによって軽鎖を直接リン酸化された平滑筋ミオシンのin vitro motility解析2008
- Author(s)
  川道穂津美
- Organizer
  筋生理の集い
- Place of Presentation
  東京慈恵会医科大学
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] Rhoキナーゼによって軽鎖を直接リン酸化された平滑筋ミオシンのin vitro motility解析2008
- Author(s)
  川道穂津美
- Organizer
  筋生理の集い
- Place of Presentation
  慈恵医大、東京
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] Calcium-independent and direct phosphorylation of smooth muscle myosin light chain by Rho-kinase is alone sufficient to stimulate actomyosin sliding at the maximum velocity leading to calcium-sensitization2008
- Author(s)
  H.Kawamichi
- Organizer
  第31回心筋代謝研究会
- Place of Presentation
  東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] カルシウム非存在下で平滑筋収縮クロスブリッジはサイクリング可能か? 〜1分子リアルタイム可視化解析による検討〜2008
- Author(s)
  川道穂津美
- Organizer
  第110回山口大学医学会
- Place of Presentation
  霜仁会館、山口
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] カルシウム非存在下で平滑筋収縮クロスブリッジはサイクリング可能か?～1分子リアルタイム可視化解析による検討～2008
- Author(s)
  川道穂津美
- Organizer
  第110回山口大学医学会
- Place of Presentation
  山口大学
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] Ca^<2+>-independent and direct phosphorylation of myosin by Rho-kinase can solelystimulate actoxmyosin sliding at the maximum velocity.2008
- Author(s)
  H. Kawamichi
- Organizer
  第85回日本生理学会
- Place of Presentation
  京王プラザホテル東京、東京
- Data Source
  KAKENHI-PROJECT-18700391
[Presentation] RhoキナーゼによってC a2+-非依存性に直接リン酸化された平滑筋ミオシンは、アクチンとの滑り運動を最大速度で引き起こすことが出来る2008
- Author(s)
  川道穂津美
- Organizer
  第46回日本生物物理学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] RhoキナーゼによってCa_<2+>-非依存性に直接リン酸化された平滑筋ミオシンは、アクチンとの滑り運動を最大速度で引き起こすことが出来る2008
- Author(s)
  川道穂津美
- Organizer
  第46回日本生物物理学会
- Place of Presentation
  福岡国際会議場、福岡
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] Calcium-independent and direct phosphorylation of smooth muscle myosin light chain by Rho-kinase is alone sufficient to stimulate actomyosin sliding at the maximum velocity leading to calcium-sensitization2008
- Author(s)
  H. Kawamichi
- Organizer
  第31回心筋代謝研究会
- Place of Presentation
  東京慈恵会医科大学
- Data Source
  KAKENHI-PROJECT-20700359
[Presentation] 血管平滑筋のカルシウム非依存性収縮におけるアクトミオシン運動の解析2007
- Author(s)
  川道徳津美
- Organizer
  第45回日本生物物理学会
- Place of Presentation
  パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-18700391
[Presentation] Fyn tyrosine kinase is a novel signal molecule of the rho-kinasemediated-abnormal contraction of vascular smooth muscle.2007
- Author(s)
  H. Kawamichi
- Organizer
  第30回心筋代謝研究会
- Place of Presentation
  ぱるるプラザ京都
- Data Source
  KAKENHI-PROJECT-18700391

1. KOBAYASHI Sei (80225515)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. KISHI Hiroko (40359899)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. KAJIYA Katsuko (00379942)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results

KAWAMICHI Hozumo 川道 穂津美

Research Projects

Research Products

Co-Researchers

The elucidation of the relationship between vascular smooth muscle contraction and cytoskeletal rearrangement by proteomics and functional analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管攣縮の病的シグナル分子機能を時空間リアルタイム可視化観察するシステムの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of molecular mechanisms of abnormal vascular contraction by functional proteomics and a single molecular analysis of signal transduction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of vasospasm by a spatiotemporal nanoscale analysis of signal molecules.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管平滑筋の異常収縮シグナル伝達の可視化による解明と創薬スクリーニングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional roles of membrane domain and its localized component proteins in abnormal vascular contraction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Focused proteomic approach to identify novel signaling molecules for abnormal vascular smooth muscle contraction2010

Author(s)

Journal Title

Data Source

[Journal Article] Focused Proteomicsによる、血管平滑筋異常収縮の新規病的シグナル分子の探索2010

Author(s)

Journal Title

Data Source

[Journal Article] 日薬理誌2009

Author(s)

Journal Title

Data Source

[Journal Article] 血管異常収縮の分子機構と分子標的治療薬の探索2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 血管異常収縮の分子機構と分子標的治療薬の探索2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 血管異常収縮の分子機構と分子標的治療薬の探索2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Time Studies2008

Author(s)

Journal Title

Data Source

[Journal Article] Watching the motion pictures off signal molecules of the abnormal vascular contraction! Spatiotemporal nanoscale analysis of intracellular abnormality2008

Author(s)

Journal Title

Data Source

KAWAMICHI Hozumo 川道穂津美