OKUNO Yutaka 奥野豊

Researcher Number	80363539
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2018: 熊本大学, 大学院生命科学研究部(医), 准教授 2017: 熊本大学, 大学院生命科学研究部, 准教授 2015: 熊本大学, その他の研究科, 准教授 2013 – 2014: 熊本大学, 大学院生命科学研究部, 准教授 2013: 熊本大学, 生命科学研究部, 准教授 … More 2012: 熊本大学, 医学部附属病院, 講師 2011: 熊本大学, 大学院生命科学研究部, 助教 2009 – 2010: Kumamoto University, 大学院・生命科学研究部, 助教 2009: 熊本大学, 医学部・附属病院, 助教 2008: Kumamoto University, 大学院・医学薬学研究部, 助教 2007: Kumamoto University, Medicine, DEPARTMENT of Hematology, assistant of professor 2007: Kumamoto University, 大学院・医学薬学研究部, 助手 2006: 熊本大学, 大学院医学薬学研究部, 助手 2004 – 2005: 熊本大学, 大学院・医学薬学研究部, 助手 Less
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related / Biological Sciences / Biological Sciences Except Principal Investigator Hematology
Keywords	Principal Investigator PU.1 / 多発性骨髄腫 / 腫瘍抑制因子 / TRAIL / DLBCL / B細胞リンパ腫 / p21 / 細胞死 / IRF7 / ホジキンリンパ腫 … More / 細胞増殖停止 / 治療 / 古典的ホジキンリンパ腫 / B細胞腫瘍 / Mucin 1 / KL-6 / Apoptosis / Demethylation Agents / Methylation / Multiple Myeloma / アポトーシス / 脱メチル化剤 / メチル化 / 新規薬剤 / 分子標的療法薬 / 化合物スクリーニング / cell cycle arrest / apoptosis / IFNb / びまん性大細胞型B細胞リンパ腫 / IFNβ / IRF4 / 悪性リンパ腫 / tumor suppressor / 腫瘍抑制遺伝子 / M蛋白血症 / 成熟B細胞リンパ腫 / M蛋白 / 癌抑制遺伝子 / PU. 1 / Hodgkin Lymphoma / Hodgkinリンパ腫 / Flt3-ITD / CD34 / 白血病幹細胞 … More Except Principal Investigator 治療 / 白血病 / コレステロール / リンパ腫 / 予後 / IRF4 / PU.1 / 多発性骨髄腫 / 血液腫瘍学 Less

Elucidation of mechanisms of emergences of B cell malignancies by PU.1 down-regulation and its application for treatment strategiesPrincipal Investigator
- Principal Investigator
  
  奥野豊
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Anti-lymphoma therapy targeting cholesterol metabolism
- Principal Investigator
  
  Komohara Yoshihiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
Treatment strategy with PU.1 induction in multiple myeloma and Hodgkin lymphomaPrincipal Investigator
- Principal Investigator
  
  Okuno Yutaka
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
PU.1発現低下の骨髄腫発症への関与の解明Principal Investigator
- Principal Investigator
  
  奥野豊
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
The elucidation of the mechanisms of growth arrest and apoptosis in myeloma cells induced by PU.1 and its utility for myeloma treatmentPrincipal Investigator
- Principal Investigator
  
  OKUNO YUTAKA
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
Elucidation of the mechanisms of growth arrest and apoptosis of myeloma cells induced by PU. 1 that may result in new molecular target therapy of multiple myeloma patientsPrincipal Investigator
- Principal Investigator
  
  OKUNO Yutaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
Stratification of multiple myeloma according to PU.1 expression level
- Principal Investigator
  
  TATETSU Hiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
Downregulation of PU.1 is required for myeloma cell growthPrincipal Investigator
- Principal Investigator
  
  OKUNO Yutaka
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
白血病モデルマウスよりの白血病幹細胞の同定とその性状の解析Principal Investigator
- Principal Investigator
  
  奥野豊
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University

[Book] 血液疾患最新の治療2014-2016 "多発性骨髄腫”2014
- Author(s)
  奥野　豊、畑　裕之
- Total Pages
  373
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23591395
[Book] 血液疾患最新の治療2014-2016, 多発性骨髄腫2014
- Author(s)
  奥野豊、畑裕之
- Total Pages
  373
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23591395
[Book] 血液疾患最新の治療2014-2016 "多発性骨髄腫”2014
- Author(s)
  奥野　豊、畑　裕之
- Total Pages
  373
- Publisher
  南江堂
- Data Source
  KAKENHI-PUBLICLY-25118719
[Book] みのがしてはならない血液疾患病理からみた44症例2014
- Author(s)
  菰原義弘、奥野豊、竹屋元裕
- Total Pages
  278
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-23591395
[Book] みのがしてはならない血液疾患　病理からみた44症例2014
- Author(s)
  菰原　義弘、奥野　豊、竹屋　元裕
- Total Pages
  278
- Publisher
  医学書院
- Data Source
  KAKENHI-PUBLICLY-25118719
[Book] みのがしてはならない血液疾患　病理からみた44症例2014
- Author(s)
  菰原　義弘、奥野　豊、竹屋　元裕
- Total Pages
  278
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-23591395
[Book] 血液症候群(第2版)III2013
- Author(s)
  奥野豊
- Total Pages
  767
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-23591395
[Book] 血液症候群(第2版）III2013
- Author(s)
  奥野　豊
- Total Pages
  767
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PUBLICLY-25118719
[Book] 血液症候群(第2版）III2013
- Author(s)
  奥野　豊
- Total Pages
  767
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] Base-to-apex gradient pattern of cardiac impairment identified on myocardial T1 mapping in cardiac amyloidosis2019
- Author(s)
  Oda Seitaro、Kawano Yawara、Okuno Yutaka、Utsunomiya Daisuke、Nakaura Takeshi、Tsujita Kenichi、Yamashita Yasuyuki
- Journal Title
  
  Radiology Case Reports
  
  Volume: 14 Issue: 1 Pages: 72-74
- DOI
  10.1016/j.radcr.2018.09.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08363
[Journal Article] Bufalin induces DNA damage response under hypoxic condition in myeloma cells2018
- Author(s)
  Fujii Eri、Inada Yuki、Kakoki Misaki、Nishimura Nao、Endo Shinya、Fujiwara Shiho、Wada Naoko、Kawano Yawara、Okuno Yutaka、Sugimoto Toshiya、Hata Hiroyuki
- Journal Title
  
  Oncology Letters
  
  Volume: 15 Pages: 6443-6449
- DOI
  10.3892/ol.2018.8091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08363
[Journal Article] Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma2018
- Author(s)
  Yoshihiro Komohara,1,2) Osamu Noyori,3) Yoichi Saito,1) Hiroto Takeya,1) Muhammad Baghdadi,4) Fumihito Kitagawa,4) Naoki Hama,4) Kozo Ishikawa,4) Yutaka Okuno,5) Kisato Nosaka,5) Ken-ichiro Seino,4) Masao Matsuoka,5) and Shinya Suzu3)
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 58 Issue: 4 Pages: 152-160
- DOI
  10.3960/jslrt.18034
- NAID
  130007529824
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08763, KAKENHI-PROJECT-17K09913, KAKENHI-PROJECT-18K08363, KAKENHI-PROJECT-16H06277
[Journal Article] Differential roles of Rad18 and Chk2 in genome maintenance and skin carcinogenesis following UV exposure.2018
- Author(s)
  Tanoue, Y., Toyoda, T., Sun, J, Mustofa, M.K., Tateishi, C., Endo, S., Motoyama, N., Araki, K., Wu, D., Okuno, Y., Tsukamoto, T., Takeya, M., Ihn, H., Vaziri, C., Tateishi, S.
- Journal Title
  
  J. Invest. Dermatol.
  
  Volume: 138 Issue: 12 Pages: 2550-2557
- DOI
  10.1016/j.jid.2018.05.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11646, KAKENHI-PROJECT-17H04060, KAKENHI-PROJECT-16K00878, KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-16K10165, KAKENHI-PROJECT-18K08363, KAKENHI-PROJECT-16K15248
[Journal Article] Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/<i>RUNX1-RUNX1T1</i> Rearrangement2018
- Author(s)
  Tokunaga Kenji、Yamamura Ayako、Ueno Shikiko、Kikukawa Yoshitaka、Yamaguchi Shunichiro、Hidaka Michihiro、Matsuno Naofumi、Kawaguchi Tatsuya、Matsuoka Masao、Okuno Yutaka
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 4 Pages: 563-568
- DOI
  10.2169/internalmedicine.8912-17
- NAID
  130006351526
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08363
[Journal Article] MUC1/KL-6 expression confers an aggressive phenotype upon myeloma cells2018
- Author(s)
  Endo Shinya、Nishimura Nao、Kawano Yawara、Ueno Niina、Ueno Shikiko、Tatetsu Hiro、Komohara Yoshihiro、Takeya Motohiro、Hata Hiroyuki、Mitsuya Hiroaki、Masao Matsuoka、Okuno Yutaka
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 507 Issue: 1-4 Pages: 246-252
- DOI
  10.1016/j.bbrc.2018.11.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04060, KAKENHI-PROJECT-18K08363
[Journal Article] PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF42017
- Author(s)
  Ueno N, Nishimura N, Ueno S, Endo S, Tatetsu H, Hirata S, Hata H, Matsuoka M, Mitsuya H, Okuno Y.
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 31 Pages: 4481-4497
- DOI
  10.1038/onc.2017.79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461427
[Journal Article] Restoring PU.1 induces apoptosis and modulates viral transactivation via interferon-stimulated genes in primary effusion lymphoma2017
- Author(s)
  Goto H、Kariya R、Kudo E、Okuno Y、Ueda K、Katano H、Okada S
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 37 Pages: 5252-5262
- DOI
  10.1038/onc.2017.138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08742, KAKENHI-PROJECT-16H07080, KAKENHI-PROJECT-26461427
[Journal Article] A xenograft model reveals that PU.1 functions as a tumor suppressor for multiple myeloma in vivo2017
- Author(s)
  Nishimura N, Endo S, Ueno S, Ueno N, Tatetsu H, Hirata S, Hata H, Komohara Y, Takeya M, Mitsuya H, Okuno Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461427
[Journal Article] A xenograft model reveals that PU.1 functions as a tumor suppressor for multiple myeloma in vivo.2017
- Author(s)
  Nishimura N, Endo S, Ueno S, Ueno N, Tatetsu H, Hirata S, Hata H, Komohara Y, Takeya M, Mitsuya H, Okuno Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 486 Issue: 4 Pages: 916-922
- DOI
  10.1016/j.bbrc.2017.03.124
- Data Source
  KAKENHI-PROJECT-26461427
[Journal Article] Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages.2017
- Author(s)
  Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 57 Issue: 1 Pages: 15-20
- DOI
  10.3960/jslrt.17003
- NAID
  130005709559
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09247, KAKENHI-PROJECT-17K08763, KAKENHI-PROJECT-16K15248, KAKENHI-PROJECT-17H04060, KAKENHI-PROJECT-26461427
[Journal Article] Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 12015
- Author(s)
  Fujiwara S, Wada N, Kawano Y, Okuno Y, Kikukawa Y, Endo S, Nishimura N, Ueno N, Mitsuya H, Hata H.
- Journal Title
  
  Exp Hematol Oncol.
  
  Volume: 21 Issue: 1
- DOI
  10.1186/s40164-015-0008-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461427
[Journal Article] Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.2015
- Author(s)
  Wada N, Kawano Y, Fujiwara S, Kikukawa Y, Okuno Y, Tasaki M, Ueda M, Ando Y, Yoshinaga K, Ri M, Iida S, Nakashima T, Shiotsu Y, Mitsuya H, Hata H.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 46 Issue: 3 Pages: 963-972
- DOI
  10.3892/ijo.2014.2804
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25118719, KAKENHI-PROJECT-25870541, KAKENHI-PROJECT-26860372, KAKENHI-PROJECT-26461427
[Journal Article] Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells.2015
- Author(s)
  Endo S, Amano M, Nishimura N, Ueno N, Ueno S, Yuki H, Fujiwara S, Wada N, Hirata S, Hata H, Mitsuya H, Okuno Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 469 Issue: 2 Pages: 236-242
- DOI
  10.1016/j.bbrc.2015.11.116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-26461427, KAKENHI-PROJECT-25461499
[Journal Article] Transcriptional dysregulation of the deleted in colorectal carcinoma gene in multiple myeloma and monoclonal gammopathy of undetermined significance.2015
- Author(s)
  Nagoshi H, Taki T, Chinen Y, Tatekawa S, Tsukamoto T, Maegawa S, Yamamoto-Sugitani M, Tsutsumi Y, Kobayashi T, Matsumoto Y, Horiike S, Okuno Y, Fujiwara S, Hata H, Kuroda J, Taniwaki M.
- Journal Title
  
  Genes Chromosomes Cancer
  
  Volume: 54 Issue: 12 Pages: 788-795
- DOI
  10.1002/gcc.22290
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09486, KAKENHI-PROJECT-26461427, KAKENHI-PROJECT-26461429
[Journal Article] Combined use of bortezomib, cyclophosphamide, and dexamethasone induces favorable hematological and organ responses in Japanese patients with amyloid light-chain amyloidosis: a single-institution retrospective study.2014
- Author(s)
  Kikukawa Y, Yuki H, Hirata S, Ide K, Nakata H, Miyakawa T, Matsuno N, Nosaka K, Yonemura Y, Kawaguchi T, Hata H, Mitsuya H, Okuno Y.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 101 Issue: 2 Pages: 133-139
- DOI
  10.1007/s12185-014-1705-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25118719, KAKENHI-PROJECT-25461499, KAKENHI-PROJECT-26461427
[Journal Article] Regression of primary rectal MALT lymphoma after Helicobacter pylori eradication2014
- Author(s)
  Nosaka K, Shono T, Yonemura Y, Iyama K, Sasaki Y, Endo S, Okuno Y, Mitsuya H.
- Journal Title
  
  臨床血液
  
  Volume: 55 Pages: 948-952
- NAID
  130004688008
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25118719
[Journal Article] Complete remission achieved by a combination regimen with bortezomib, cyclophosphamide, and dexamethasone in a multiple myeloma patient with elevated serum KL-6 level.2014
- Author(s)
  Okuno Y, Nishimura N, Nosaka K, Hata H, Mitsuya H.
- Journal Title
  
  臨床血液
  
  Volume: 55 Pages: 948-952
- NAID
  130004920674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461427
[Journal Article] Regression of primary rectal MALT lymphoma after Helicobacter pylori eradication.2014
- Author(s)
  Nosaka K, Shono T, Yonemura Y, Iyama K, Sasaki Y, Endo S, Okuno Y, Mitsuya H.
- Journal Title
  
  臨床血液
  
  Volume: 55 Pages: 948-952
- NAID
  130004688008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461427
[Journal Article] Complete remission achieved in a multiple myeloma patient with elevated serum KL-6 level by a combination regimen with bortezomib, cyclophosphamide, and dexamethasone.2014
- Author(s)
  Okuno Y, Nishimura N, Nosaka K, Hata H, & Mitsuya H
- Journal Title
  
  臨床血液
  
  Volume: 55 Pages: 461-465
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25118719
[Journal Article] Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells2013
- Author(s)
  Kawano Y, Kikukawa Y, Fujiwara S, Wada N, Okuno Y, Mitsuya H, Hata H
- Journal Title
  
  Int J Oncol
  
  Volume: 43(6) Pages: 1809-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells2013
- Author(s)
  Kawano Y, Kikukawa Y, Fujiwara S, Wada N, Okuno Y, Mitsuya H, Hata H
- Journal Title
  
  International Journal of Oncology
  
  Volume: 43 Issue: 6 Pages: 1809-1816
- DOI
  10.3892/ijo.2013.2134
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25118719
[Journal Article] PDK1 inhibition is a novel therapeutic target in multiple myeloma2013
- Author(s)
  Fujiwara S, Kawano Y, Yuki H, Okuno Y, Nosaka K, Mitsuya H and Hata H
- Journal Title
  
  Br J Cancer
  
  Volume: 108(1) Pages: 170-178
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells2013
- Author(s)
  Yuki H, Ueno S, Tatetsu H, Niiro H, Iino T, Endo S, Kawano Y, Komohara Y, Takeya M, Hata H, Okada S, Watanabe T, Akashi K, Mitsuya H and Okuno Y
- Journal Title
  
  Blood
  
  Volume: 121(6) Pages: 962-970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] PDK1 inhibition is a novel therapeutic target in multiple myeloma.2013
- Author(s)
  Fujiwara, S., Kawano, Y., Yuki, H., Okuno, Y., Nosaka, K., Mitsuya, H., and Hata, H.
- Journal Title
  
  Br J Cancer
  
  Volume: 108 Issue: 1 Pages: 170-178
- DOI
  10.1038/bjc.2012.527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] Three cases of aggressive natural killer cell leukemia with a lethal hemorrhagic complication.2012
- Author(s)
  Okuno, Y., Tatetsu, H., Nosaka, K., and Mitsuya, H.
- Journal Title
  
  J Clin Exp Hematop
  
  Volume: 52 Pages: 101-106
- NAID
  10031120433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] PU.1 is a tumor suppressor for B cell malignancies2012
- Author(s)
  Okuno Y and Yuki H
- Journal Title
  
  Oncotarget
  
  Volume: 3(12) Pages: 1495-1496
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells.2012
- Author(s)
  Yuki H
- Journal Title
  
  Blood
  
  Volume: 121 Issue: 6 Pages: 962-970
- DOI
  10.1182/blood-2012-05-431429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249039, KAKENHI-PROJECT-23591395, KAKENHI-PROJECT-24591450, KAKENHI-PUBLICLY-25118719, KAKENHI-PLANNED-22130002
[Journal Article] Three Cases of Aggressive Natural Killer Cell Leukemia with a Lethal Hemorrhagic Complication2012
- Author(s)
  Yutaka Okuno, Hiro Tatetsu, Kisato Nosaka, and Hiroaki Mitsuya
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: In press
- NAID
  10031120433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] TRAIL produced from multiple myeloma cells is associated with osteolytic markers2012
- Author(s)
  Kawano Y, Ueno S, Abe M, Kikukawa Y, Yuki H, Iyama K, Okuno Y, Mitsuya H and Hata H
- Journal Title
  
  Oncology Reports
  
  Volume: 27 Pages: 39-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] PU.1 is a tumor suppressor for B cell malignancies.2012
- Author(s)
  Okuno, Y., and Yuki, H.
- Journal Title
  
  Oncotarget
  
  Volume: 3 Pages: 1495-1496
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] Three cases of aggressive natural killer cell leukemia with a lethal hemorrhagic complication2012
- Author(s)
  Okuno Y, Tatetsu H, Nosaka K and Mitsuya H
- Journal Title
  
  J Clin Exp Hematop
  
  Volume: 52(2) Pages: 101-106
- NAID
  10031120433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] Multiple myeloma cells expressing low levels of CD138 have an immature phenotype and reduced sensitivity to lenalidomide2012
- Author(s)
  Kawano Y, Fujiwara S, Wada N, Izaki M, Yuki H, Okuno Y, Iyama K, Yamasaki H, Sakai A, Mitsuya H and Hata H
- Journal Title
  
  Int J Oncol
  
  Volume: 41(3) Pages: 876-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] Multiple myeloma cells expressing low levels of CD138 have an immature phenotype and reduced sensitivity to lenalidomide.2012
- Author(s)
  Kawano, Y., Fujiwara, S., Wada, N., Izaki, M., Yuki, H., Okuno, Y., Iyama, K., Yamasaki, H., Sakai, A., Mitsuya, H., et al.
- Journal Title
  
  Int J Oncol
  
  Volume: 41 Issue: 3 Pages: 876-884
- DOI
  10.3892/ijo.2012.1545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] TRAIL produced from multiple myeloma cell is associated with osteolytic markers.2012
- Author(s)
  1. Kawano Y
- Journal Title
  
  Oncol Rep
  
  Volume: 27 Pages: 39-44
- DOI
  10.3892/or.2011.1491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591390, KAKENHI-PROJECT-23591395
[Journal Article] RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element2011
- Author(s)
  Levantini E, Lee S, Radomska H, Hetherington C, Alberich-Jorda M, Amabile G, Zhang P, Gonzalez D, Zhang J, Basseres D, Wilson N, Koschmieder S, Huang G, Zhang D, Ebralidze A, Bonifer C, Okuno Y, Gottgens B, Tenen DG
- Journal Title
  
  EMBO J
  
  Volume: 30(19) Pages: 4059-4070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591395
[Journal Article] PU. 1 induces apoptosis in myeloma cells through direct transactivation of TRAIL2009
- Author(s)
  Ueno S, Tatetsu H, Hata H, Iino T, Niiro H, Akashi K, Tenen DG, Mitsuya H, Okuno Y
- Journal Title
  
  Oncogene 28(46)
  
  Pages: 4116-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790677
[Journal Article] PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL.2009
- Author(s)
  Ueno, S., Tatetsu, H., Hata, H., Iino, T., Niiro, H., Akashi, K., Tenen, D.G., Mitsuya, H., Okuno, Y.
- Journal Title
  
  Oncogene 28
  
  Pages: 4116-4125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591135
[Journal Article] PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.2008
- Author(s)
  Huang, G., Zhang, P., Hirai, H., Elf, S., Yan, X., Chen, Z., Koschmieder, S., Okuno, Y., Dayaram, T., Growney, J.D., et al.
- Journal Title
  
  Nat Genet 40
  
  Pages: 51-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591135
[Journal Article] Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid.2008
- Author(s)
  Kikukawa, Y., Okuno, Y., Tatetsu, H., Nakamura, M., Harada, N., Ueno, S., Kamizak, i.Y., Mitsuya, H., Hata, H.
- Journal Title
  
  Int J Oncol 33
  
  Pages: 807-814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591135
[Journal Article] 2008.PU.1 is a major downstream target of AML1(RUNX1) in adult mouse hematopoiesis2007
- Author(s)
  Huang, G. ; Zhang, P. ; Hirai, H. ; Elf, S. ; Yan, X. ; Chen, Z. ; Koschmieder, S. ; Okuno, Y. ; Dayaram, T. ; Growney, .J.D, ; Shivdasani, R. A. ; Gilliland D. G. : Speck, N. A ; Nimer, SD. ; Tenen, D. G ; Kikukawa, Y. ; H.
- Journal Title
  
  Nat Genet 2011
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Molecular mechanisms inhibiting proliferation of myeloma cells2007
- Author(s)
  Kikukawa, Y., Okuno Y., Hata, H
- Journal Title
  
  Nippon Rinsho 65 : 2
  
  Pages: 2195-2201
- NAID
  40015721736
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Down-regulation of PU.1 by Methylation of Distal Regulatory Elements and the Promoter Is Required for Myeloma Cell Growth2007
- Author(s)
  Tatetsu, H, Ueno, S, Hata H., Yamada, Takeya, M. Mitsuya, H., Temen, D.G., Okuno, Y
- Journal Title
  
  Cancer Res 67
  
  Pages: 5328-5336
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Downregulation of PU. 1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth.2007
- Author(s)
  Tatetsu H., Okuno Y.et al.
- Journal Title
  
  Cancer Research (In press)
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Activation of endoplasmic reticulum stress pathway is associated with survival of myeloma cells.2006
- Author(s)
  Nakamura M, Okuno Y, et al.
- Journal Title
  
  Leukemia Lymphoma 47
  
  Pages: 531-9
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells2006
- Author(s)
  Nakamura, M. Gotoh, T. Okuno, Y., Tatetsu, H., Sonoki, T., Uneda, S., Mori, M., Mitsuya, H., Hata, H
- Journal Title
  
  Leuk Lymphoma 47
  
  Pages: 531-539
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.2005
- Author(s)
  Okuno Y, Huang G, Rosenberg F, Evans EK, Radomska HS, Iwasaki H, Akashi K, Moreau-Gachelin F, Li Y, Zhang P, Gottgens B, Tenen DG.
- Journal Title
  
  Molecular Cellular Biology 25
  
  Pages: 2832-2845
- Data Source
  KAKENHI-PROJECT-16021245
[Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear factor{kappa}B inhibitor, induces apoptosis in multiple myeloma cells in an I{kappa}B{alpha}-independent manner.2005
- Author(s)
  Tatetsu, H., Okuno, Y., Nakamura, M., Matsuno, F., Sonoki, T., Taniguchi, I., Uneda, S., Umezawa, K., Mitsuya, H., Hata, H
- Journal Title
  
  Mol Cancer Ther 4
  
  Pages: 1114-1120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Potential autoregulation of transcription factor PU.l by an upstream regulatory element.2005
- Author(s)
  Okuno, Y., Huang, G., Rosenbauer, F., Evans, E. K., Radomska, H, S Iwasaki, H., Skashi, K., Moreau-Gachelin, F., Li, Y., Zhang, P., et. al.
- Journal Title
  
  Mol Cell Biol 25
  
  Pages: 2832-2845
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Potential autoregulation of transcription factor PU.1 by an upstream regulatory element2005
- Author(s)
  Okuno Y et al.
- Journal Title
  
  Molecular Cellular Biology 25・7
  
  Pages: 2832-2845
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Potential autoregulation of transcription factor PU.l by an upstream regulatory element2005
- Author(s)
  Okuno, Y., et. al.
- Journal Title
  
  Mol Cell Biol 25
  
  Pages: 2832-2845
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591002
[Journal Article] Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.2004
- Author(s)
  Rosenbauer F, Wagner K, Kutok JL, Iwasaki H, Le Beau MM, Okuno Y, Akashi K, Fiering S, Tenen DG.
- Journal Title
  
  Nature Genetics 36
  
  Pages: 624-630
- Data Source
  KAKENHI-PROJECT-16021245
[Presentation] Elotuzumab plus lenalidomide/dexamethasone prolongs survival duration of relapsed and refractory (RR) multiple myeloma patients2018
- Author(s)
  奥野　豊、河野　和、上野　志貴子、畑　裕之、松岡　雅雄
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18K08363
[Presentation] A case of multiple myeloma suffered from interstitial pneumonitis induced by carfilzomib treatment2017
- Author(s)
  Miyu Sonoda, Hiro Tatetsu, Shikiko Ueno, Yawara Kawano, Kisato Nosaka, Masao Matsuoka, Yutaka Okuno
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-26461427
[Presentation] PU.1 down-regulates IRF4 by direct transcriptional suppression in myeloma cells2017
- Author(s)
  Niina Ueno, Nao Nishimura, Shikiko Ueno, Shinya Endo, Hiro Tatetsu, Masao Matsuoka, Hiroaki Mitsuya, and Yutaka Okuno
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-26461427
[Presentation] PU.1 is tumor suppressor for B cell Malignancies2016
- Author(s)
  奥野　豊
- Organizer
  リンパ網内系学会
- Place of Presentation
  ホテル日航熊本
- Invited
- Data Source
  KAKENHI-PROJECT-26461427
[Presentation] IMiDs up-regulate PU.1 expression in myeloma cell through demethylation of the PU.1 promoter region2016
- Author(s)
  Shinya Endo, Masayuki Amano, Nao Nishimura, Shikiko Ueno, Niina Ueno, Hiromichi Yuki, ShihoFujiwara, Naoko Wada, Shinya Hirata, Hiroyuki Hata, Hiroaki Mitsuya, and Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  ホテル金沢
- Year and Date
  2016-10-18
- Data Source
  KAKENHI-PROJECT-26461427
[Presentation] Serum KL-6 elevation is associated with aggressive phenotype of multiple myeloma2016
- Author(s)
  Shinya Endo, Nao Nishimura, Shikiko Ueno, Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26461427
[Presentation] Preference usage of certain V regions in AL amyloidosis patients2016
- Author(s)
  Nao Nishimura, Shinya Endo, Eri Fuji, Niina Ueno, Shikiko Ueno, Hiromichi Yuki, Hiroyuki Hata, Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26461427
[Presentation] OSSL_325096 Induces Apoptosis in Multiple Myeloma Cells through VCP inhibition2016
- Author(s)
  Nao Nishimura, Eri Fuji, Shinya Endo, Niina Ueno, Hironori Hayashi, Masayuki Amano, Hiroyuki Hata, Hiroaki Mitsuya, and Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  石川県立音楽堂地下1階交流ホール
- Year and Date
  2016-10-16
- Data Source
  KAKENHI-PROJECT-26461427
[Presentation] ALアミロイドーシス患者における免疫グロブリン軽鎖遺伝子可変領域選択性2016
- Author(s)
  Nao Nishimura, Shinya Endo, Eri Fuji, Niina Ueno, Shikiko Ueno, Hiromichi Yuki, Hiroyuki Hata, Yutaka Okuno
- Organizer
  日本骨髄腫学会
- Place of Presentation
  あわぎんホール
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-26461427
[Presentation] PU.1-induced IRF4 down-regulation and subsequent IRF7 up-regulation in myeloma cells2016
- Author(s)
  Niina Ueno, Shikiko Ueno, Shinya Endo, Nao Nishimura, Hiro Tatetsu, Kisato Nosaka, Shinya Hirata, Hiroaki Mitsuya, and Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  ホテル金沢
- Year and Date
  2016-10-18
- Data Source
  KAKENHI-PROJECT-26461427
[Presentation] PU.1-Induced IRF4 Down-Regulation and Subsequent IRF7 up-Regulation in Myeloma Cells2016
- Author(s)
  Niina Ueno, Shikiko Ueno, Shinya Endo, Nao Nishimura, Hiro Tatetsu, Shinya Hirata, Hiroaki Mitsuya, and Yutaka Okuno
- Organizer
  アメリカ血液学会
- Place of Presentation
  Orange County Convention Center, Orland, USA
- Year and Date
  2016-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461427
[Presentation] Inhibitory effect on Lymphoma Cell Proliferation by Regulating Cholesterol Metabolism Pathway2016
- Author(s)
  Yukio Fujiwara, Hasita Horlad, Daisuke Niino, Yutaka Okuno, Kikukawa Yoshitaka, Masao Matsuoka, Motohiro Takeya, Yoshihiro Komohara,
- Organizer
  THE 1ST MEETING OF THE YONGLIN HEALTHCARE SYMPOSIUM SERIES-“DNA PROCESSES, DRUGS AND CANCER”
- Place of Presentation
  台湾
- Year and Date
  2016-11-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15503
[Presentation] IRF4 down-regulation may be involved in PU.1-induced growth arrest/apoptosis in myeloma cells2013
- Author(s)
  Niina Ueno, Shikiko Ueno, Hiro Tatetsu, Hiromichi Yuki, Hiroyuki Hata, Tadafumi Iino, Hiroaki Niiro, Koichi Akashi, Hiroaki Mitsuya, Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PUBLICLY-25118719
[Presentation] Conditional knockout of PU.1 in plasma cells results in monoclonal gammopathy2013
- Author(s)
  Shinya Endo, Hiromichi Yuki, Yoshihiro Komohara, Shikiko Ueno, Hiro Tatetsu, Motohiro Takeya, Seiji Okada, Koichi Akashi, Daniel G Tenen, Hiroaki Mitsuya, Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2013-10-11
- Data Source
  KAKENHI-PROJECT-23591395
[Presentation] Conditional knockout of PU.1 in plasma cells results in monoclonal gammopathy2013
- Author(s)
  Shinya Endo, Hiromichi Yuki, Yoshihiro Komohara, Shikiko Ueno, Hiro Tatetsu, Motohiro Takeya, Seiji Okada, Koichi Akashi, Daniel G Tenen, Hiroaki Mitsuya, Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PUBLICLY-25118719
[Presentation] IRF4 down-regulation may be involved in PU.1-induced growth arrest/apoptosis in myeloma cells2013
- Author(s)
  Niina Ueno , Shikiko Ueno, Hiro Tatetsu, Hiromichi Yuki , Hiroyuki Hata, Tadafumi Iino, Hiroaki Niiro, Koichi Akashi, Hiroaki Mitsuya, Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2013-10-11
- Data Source
  KAKENHI-PROJECT-23591395
[Presentation] Successful treatment by VRCD therapy of multiple myeloma (MM) patients refractory to RCD or VCD2013
- Author(s)
  Yutaka Okuno, Eiko Miyagawa, Rie Furuta, Shinya Hirata, Hiroyuki Hata, Hiroaki Mitsuya
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2013-10-11
- Data Source
  KAKENHI-PROJECT-23591395
[Presentation] Successful treatment by VRCD therapy of multiple myeloma (MM) patients refractory to RCD or VCD2013
- Author(s)
  Yutaka Okuno, Eiko Miyagawa, Rie Furuta, Shinya Hirata, Hiroyuki Hata, Hiroaki Mitsuya
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PUBLICLY-25118719
[Presentation] PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells2012
- Author(s)
  Hiromichi Yuki , Shikiko Ueno, Hiro Tatetsu, Hiroaki Niiro, Hiroyuki Hata, Seiji Okada, Toshiki Watanabe, Koichi Akashi, Hiroaki Mitsuya, Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-23591395
[Presentation] PU.1 is a potent tumor suppressor for classical Hodgkin lymphoma cells2012
- Author(s)
  Hiromichi Yuki , Shikiko Ueno, Hiro Tatetsu, Hiroaki Niiro, Hiroyuki Hata, Seiji Okada, Toshiki Watanabe, Koichi Akashi, Hiroaki Mitsuya, Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-23591395
[Presentation] PU.1-induced growth arrest and apoptosis in classical Hodgkin lymphoma cells2011
- Author(s)
  Hiromichi Yuki , Shikiko Ueno, Hiroaki Niiro, Hiro Tatetsu, Hiroyuki Hata, Toshiki Watanabe, Seiji Okada, Koichi Akashi, Hiroaki Mitsuya, Yutaka Okuno
- Organizer
  アメリカ血液学会
- Place of Presentation
  サンディエゴ
- Year and Date
  2011-12-05
- Data Source
  KAKENHI-PROJECT-23591395
[Presentation] PU.1-induced growth arrest and apoptosis in classical Hodgkin lymphoma cell lines2011
- Author(s)
  Hiromichi Yuki, Shikiko Ueno, Hiro Tatetsu, Hiroaki Niiro, Hiroyuki Hata, Toshiki Watanabe, Koichi Akashi, Hiroaki Mitsuya, Yutaka Okuno
- Organizer
  日本血液学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23591395
[Presentation] PU.1-induced growth arrest of Hodgkin lymphoma cell line, L-4282009
- Author(s)
  奥野豊
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20591135
[Presentation] PU.1-induced growth arrest of Hodgkin lymphoma cell line, L-4282009
- Author(s)
  奥野豊
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20591135
[Presentation] Microarray analysis of PU.l-induced growth arrest and apoptosis of myeloma cell lines.2007
- Author(s)
  Shikiko, Ueno, Hiro, Tatetsu, Naoko, Harada, Hiroyuki, Hata, Tadafumi, lino, Hiroaki, Niiro, Koichi, Akashi, G., Daniel, Tenen, Hiroaki, Mitsuya, Yutaka, Okuno
- Organizer
  American Society of Hemetology, Sunday
- Place of Presentation
  Georgia World Congress Center Atlanta Georgia
- Year and Date
  2007-12-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Presentation] PU.1 is downregulated in a subset of multiple myeloma by the methylation of its "17 kb upstream regulatory region and the promoter.2006
- Author(s)
  Yutaka, Okuno, Hiro, Tatetsu, Shikiko, Ueno, Hiroyuki, Hata, Yasuhiro, Yamada, Motohiro, Takeya, Tadafumi, lino, Koichi, Akashi, Daniel, G., Tenen, Hiroaki, Mitsuya
- Organizer
  American Society of Hemetology
- Place of Presentation
  Orange County Convention Center Orlando, Florida
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591002
[Presentation] PU.1 is downregulated in a subset of multiple myeloma by the methylation of its-17kb upstream regulatory region and the promoter2006
- Author(s)
  奥野豊
- Organizer
  アメリカ血液学会
- Place of Presentation
  Orange County Convention Center Orlando,Florida
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591002

1. HATA Hiroyuki (70271129)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. TATETSU Hiro (00433029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. UENO Shikiko (40571047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Komohara Yoshihiro (40449921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Matsuoka Masao (10244138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 麻生範雄 (50175171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 哈斯塔 (00644840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤原章雄 (70452886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 岡田誠治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 天野将之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 滝智彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 立石智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 竹屋元裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. HORLAD Hasita

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKUNO Yutaka 奥野 豊

Research Projects

Research Products

Co-Researchers

Elucidation of mechanisms of emergences of B cell malignancies by PU.1 down-regulation and its application for treatment strategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Anti-lymphoma therapy targeting cholesterol metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Treatment strategy with PU.1 induction in multiple myeloma and Hodgkin lymphomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PU.1発現低下の骨髄腫発症への関与の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The elucidation of the mechanisms of growth arrest and apoptosis in myeloma cells induced by PU.1 and its utility for myeloma treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanisms of growth arrest and apoptosis of myeloma cells induced by PU. 1 that may result in new molecular target therapy of multiple myeloma patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Stratification of multiple myeloma according to PU.1 expression level

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Downregulation of PU.1 is required for myeloma cell growthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

白血病モデルマウスよりの白血病幹細胞の同定とその性状の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 血液疾患最新の治療2014-2016 "多発性骨髄腫”2014

Author(s)

Total Pages

Publisher

Data Source

[Book] 血液疾患最新の治療2014-2016, 多発性骨髄腫2014

Author(s)

Total Pages

Publisher

Data Source

[Book] 血液疾患最新の治療2014-2016 "多発性骨髄腫”2014

Author(s)

Total Pages

Publisher

Data Source

[Book] みのがしてはならない血液疾患病理からみた44症例2014

Author(s)

Total Pages

Publisher

Data Source

[Book] みのがしてはならない血液疾患 病理からみた44症例2014

Author(s)

OKUNO Yutaka 奥野豊

[Book] みのがしてはならない血液疾患　病理からみた44症例2014

[Book] みのがしてはならない血液疾患　病理からみた44症例2014