TOGO Shinsaku 十合晋作

… Alternative Names

十合晋作トウゴウシンサク

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Researcher Number	80365634
Affiliation (Current)	2025: 順天堂大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2014 – 2023: 順天堂大学, 医学部, 准教授 2011 – 2013: 順天堂大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Digestive surgery / Basic Section 53030:Respiratory medicine-related / General surgery
Keywords	Principal Investigator テロメスキャン / 循環腫瘍細胞 / 血中循環腫瘍細胞 / バイオマーカー / 肺がん / 肺癌 / 上皮間葉転換 / 非小細胞肺癌 / 非侵襲的高感度測定 / 早期癌判定バイオマーカー … More / 治療奏功予測バイオマーカー / PD-L1 / テロメスキャンOBP-401 / テロメアーゼ / 癌幹細胞 / 非小細胞肺がん / 癌微小環境 / EMT / 癌関連線維芽細胞 … More Except Principal Investigator 血中循環癌細胞 / CTC / 腫瘍マーカー / 大腸がん / 治療効果判定 / 予後予測因子 / テロメラーゼ / 大腸癌 / 硫化アリル / 特発性肺線維症 / 肺線維症 / アリシン / 薬剤感受性 / 転移能評価 / 血中循環腫瘍細胞 / 転移予測 / CTC-chip / 採血診断 / テロメスキャン / 上皮間葉移行 / 乳癌 / ﾃﾛﾒｽｷｬﾝ法 / 遠隔転移 / テロメア Less

The Effect of Allicin for Pulmonary Fibrosis
- Principal Investigator
  
  加藤元康
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Juntendo University
テロメスキャンによる高感度血中循環腫瘍細胞測定の実用化臨床研究Principal Investigator
- Principal Investigator
  
  十合晋作
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Juntendo University
Search for new biomarkers for mesenchymal circulating tumor cells using next-generation TelomeScanPrincipal Investigator
- Principal Investigator
  
  Togo Shinsaku
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Juntendo University
Clinical Application and Functional Analysis of Colorectal Cancer CTCs by New Telomescan F35
- Principal Investigator
  
  Ochiai Takumi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Juntendo University
The analysis of circulating tumor cell measurement of lung cancer by next genaration TelomeScanPrincipal Investigator
- Principal Investigator
  
  TOGO Shinsaku
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University
Isolation and functional analysis of blood circulating breast cancer cells by improved telome scan
- Principal Investigator
  
  Shimizu Hideo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Juntendo University
Isolation and functional analysis of blood circulating tumor cells in colorectal cancer using modified Telomescan system for clinical application
- Principal Investigator
  
  Ochiai Takumi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Juntendo University
The role of cancer associated fibroblast in non small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  TOGO Shinsaku
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University

All 2023 2020 2019 2017 2016 2015 2013 2012 2011

All Journal Article Presentation Book Patent

[Book] 肺癌と癌関連線維芽細胞2012
- Author(s)
  十合晋作、高橋和久
- Publisher
  中外医学社Annual Review呼吸器
- Data Source
  KAKENHI-PROJECT-23591161
[Journal Article] Mesenchymal Characteristics and Predictive Biomarkers on Circulating Tumor Cells for Therapeutic Strategy2020
- Author(s)
  Okabe Takahiro、Togo Shinsaku、Fujimoto Yuichi、Watanabe Junko、Sumiyoshi Issei、Orimo Akira、Takahashi Kazuhisa
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 12 Pages: 3588-3588
- DOI
  10.3390/cancers12123588
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07303, KAKENHI-PROJECT-19K17684, KAKENHI-PROJECT-18K07207
[Journal Article] Specific features of fibrotic lung fibroblasts highly sensitive to fibrotic processes mediated via TGF-β-ERK5 interaction.2019
- Author(s)
  Kadoya K, Togo S, Tulafu M, Namba Y, Iwai M, Watanabe J, Okabe T, Jin J, Kodama Y, Kitamura H, Ogura T, Kitamura N, Ikeo K, Takeda T, Kondo N, Takahashi K.
- Journal Title
  
  Cell Physiol Biochem
  
  Volume: 52 Issue: 4 Pages: 822-837
- DOI
  10.33594/000000057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10653, KAKENHI-PLANNED-17H06399
[Journal Article] Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1.2019
- Author(s)
  Jin J, Togo S, Kadoya K, Tulafu M, Namba Y, Iwai M, Watanabe J, Nagahama K, Okabe T, Hidayat M, Kodama Y, Kitamura H, Ogura T, Kitamura N, Ikeo K, Sasaki S, Tominaga S, Takahashi K.
- Journal Title
  
  Respir Res
  
  Volume: 20:119 Issue: 1 Pages: 1-14
- DOI
  10.1186/s12931-019-1093-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10653
[Journal Article] Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease.2017
- Author(s)
  Onodera K, Sugiura H, Yamada M, Koarai A, Fujino N, Yanagisawa S, Tanaka R, Numakura T, Togo S, Sato K, Kyogoku Y, Hashimoto Y, Okazaki T, Tamada T, Kobayashi S, Yanai M, Miura M, Hoshikawa Y, Okada Y, Suzuki S, Ichinose M.
- Journal Title
  
  Thorax
  
  Volume: 2017 Issue: 10 Pages: 893-904
- DOI
  10.1136/thoraxjnl-2016-209352
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10653, KAKENHI-PROJECT-16K15453, KAKENHI-PROJECT-16H05307, KAKENHI-PROJECT-17H04180, KAKENHI-PROJECT-15K09207, KAKENHI-PROJECT-26462025
[Journal Article] Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.2017
- Author(s)
  Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K.
- Journal Title
  
  Respir Res.
  
  Volume: 18 Issue: 1 Pages: 46-46
- DOI
  10.1186/s12931-017-0529-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-16K15598, KAKENHI-PROJECT-17K10653, KAKENHI-PROJECT-16K15625
[Journal Article] Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients.2017
- Author(s)
  Togo S, Katagiri N, Namba Y, Tulafu M, Nagahama K, Kadoya K, Takamochi K, Oh S, Suzuki K, Sakurai F, Mizuguchi H, Urata Y, Takahashi K.
- Journal Title
  
  Oncotarget
  
  Volume: 4 Issue: 21 Pages: 16818-16818
- DOI
  10.18632/oncotarget.16818
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09191, KAKENHI-PROJECT-17K10653, KAKENHI-PROJECT-26462025, KAKENHI-PROJECT-18K07303
[Journal Article] Expression of thymidylate synthase predicts clinical outcomes of S-1-based chemotherapy in squamous cell lung cancer.2017
- Author(s)
  Honma Y, Togo S, Shimizu K, Tulafu M, Hayashi T, Uekusa T, Tominaga S, Kido K, Fujimoto Y, Nanba Y, Takamochi K, Oh S, Suzuki K, Takahashi K.
- Journal Title
  
  Oncol Lett
  
  Volume: 14(3) Issue: 3 Pages: 3319-3326
- DOI
  10.3892/ol.2017.6610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462025
[Journal Article] Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus.2016
- Author(s)
  Sakurai F, Narii N, Tomita K, Togo S, Takahashi K, Machitani M, et al.
- Journal Title
  
  Mol Ther Methods Clin Dev.
  
  Volume: 3 Pages: 16001-16001
- DOI
  10.1038/mtm.2016.1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09191, KAKENHI-PROJECT-26293118, KAKENHI-PROJECT-26462025
[Journal Article] Carcinoma-associated fibroblasts are a promising therapeutic target.2013
- Author(s)
  1. Togo S, Polanska UM, Horimoto Y, Orimo A
- Journal Title
  
  cancers
  
  Volume: 31 Issue: 1 Pages: 149-69
- DOI
  10.3390/cancers5010149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591161
[Journal Article] Carcinoma-Associated Fibroblasts are a promising therapeuic target. Review2013
- Author(s)
  S.Togo, Orimo. A et al
- Journal Title
  
  Cancers
  
  Volume: 5 Pages: 149-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591161
[Journal Article] Carcinoma-Associated Fibroblasts Are a Promising Therapeutic Target2013
- Author(s)
  Togo, S.; Polanska, U.M.; Horimoto, Y.; Orimo, A
- Journal Title
  
  Cancers
  
  Volume: 5 Pages: 149-169
- Data Source
  KAKENHI-PROJECT-23591161
[Patent] 細胞の検出方法2015
- Inventor(s)
  十合/高橋/志田/大内/浦田
- Industrial Property Rights Holder
  十合/高橋/志田/大内/浦田
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-01
- Overseas
- Data Source
  KAKENHI-PROJECT-15K09191
[Presentation] The natural compounds from garlic extract, allicin has protective effects on fibroblast mediated lung fibrosis2023
- Author(s)
  Hou Jia, Motoyasu kato, Shinsaku Togo, Shun Nakazawa, Hiroaki Motomura, Takuto Sueyasu, Haruki Hirakawa, Yusuke Ochi, Issei Sumiyoshi, Kazuhisa Takahashi
- Organizer
  日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K08241
[Presentation] Clinicopathological features and poor outcome for ALK inhibitors of squamous cell lung cancer with ALK-rearrangement2017
- Author(s)
  Motomura Y1, Watanabe J1,2, Togo S1,2, Sumiyoshi I1, Namba Y4, Suina Y1, Mizuno T6, Kadoya K1, Iwai M1.2.8,Nagaoka T1,2, Sasaki S4, Hayashi T1,2, Uekusa T6, Abe K9, Urata Y9, Sakurai F10, Mizuguchi H10, Kato S5, Takahashi K1,2.
- Organizer
  IASLC WCLC 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09191
[Presentation] ALK阻害剤耐性獲得機序を確認したALK融合遺伝子変異陽性肺扁平上皮癌の1例2017
- Author(s)
  水野　貴文、住吉　一誠、十合　晋作、田島　健、早川　乃介、推名健太郎、林　大久生、植草　利公、加藤　俊介、高橋　和久
- Organizer
  日本呼吸器学会総会
- Data Source
  KAKENHI-PROJECT-15K09191
[Presentation] Stromal fibroblasts associated with cancer cells enhanced trans differentiation in myofibroblast2012
- Author(s)
  Togo S
- Organizer
  American Thoracic Society
- Place of Presentation
  San Francisco
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-23591161
[Presentation] 非小細胞肺癌間質内における筋線維芽細胞の機能解析2011
- Author(s)
  十合　晋作
- Organizer
  第52回日本肺癌学会学術講演会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23591161
[Presentation] 非小細胞肺癌間質内における筋線維芽細胞の機能解析2011
- Author(s)
  長浜久美、十合晋作
- Organizer
  第51回日本呼吸器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591161
[Presentation] 非小細胞肺癌間質内における筋線維芽細胞の機能解析の検討2011
- Author(s)
  十合　晋作
- Organizer
  第72回日本癌学会学術講演会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591161
[Presentation] 非小細胞肺癌間質内における筋線維芽細胞の機能解析の検討2011
- Author(s)
  十合晋作
- Organizer
  第52回日本肺癌学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23591161

1. 小見山博光 (30348982)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. Ochiai Takumi (10626815)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Shimizu Hideo (50424247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 堀本義哉 (40424246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高橋和久 (80245711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 加藤元康 (70750313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. NAMBA Yukiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. MINIWAN Torafu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKA Hikari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. KAGA Naoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TOGO Shinsaku 十合 晋作

十合 晋作 トウゴウ シンサク

Research Projects

Research Products

Co-Researchers

The Effect of Allicin for Pulmonary Fibrosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

テロメスキャンによる高感度血中循環腫瘍細胞測定の実用化臨床研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for new biomarkers for mesenchymal circulating tumor cells using next-generation TelomeScanPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinical Application and Functional Analysis of Colorectal Cancer CTCs by New Telomescan F35

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of circulating tumor cell measurement of lung cancer by next genaration TelomeScanPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation and functional analysis of blood circulating breast cancer cells by improved telome scan

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation and functional analysis of blood circulating tumor cells in colorectal cancer using modified Telomescan system for clinical application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of cancer associated fibroblast in non small cell lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肺癌と癌関連線維芽細胞2012

Author(s)

Publisher

Data Source

[Journal Article] Mesenchymal Characteristics and Predictive Biomarkers on Circulating Tumor Cells for Therapeutic Strategy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Specific features of fibrotic lung fibroblasts highly sensitive to fibrotic processes mediated via TGF-β-ERK5 interaction.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.2017

Author(s)

Journal Title

TOGO Shinsaku 十合晋作

十合晋作トウゴウシンサク