KUNIMOTO Hiroyuki 國本浩之

… Alternative Names

國本浩之クニモトヒロユキ

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Researcher Number	80372853
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪公立大学, 大学院医学研究科, 助教 2014 – 2021: 大阪市立大学, 大学院医学研究科, 助教 2013 – 2014: 大阪市立大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Dermatology / Basic Section 59040:Nutrition science and health science-related / Basic Section 52030:Psychiatry-related / Basic Section 53010:Gastroenterology-related / General medical chemistry / Bio-related chemistry
Keywords	Principal Investigator 精子形成 / 選択的スプライシング / 精子形成不全 / 男性不妊症 Except Principal Investigator RBM10 / スプライシング制御因子 / S1-1 nuclear body / 活動度の自己調節機構 / 細胞分裂機構とRBM10 / RBM10遺伝子変異と疾病 … More / splicing regulator / RBM10/S1-1 / 白皮症 / 生体レジリエンス / mTORシグナル / 老化シグナル / Mdm20 / mTOR / アセチル化修飾 / マルチオミクス解析 / 細胞老化 / CRISPR / Aplysia / nuclear body / 精神病 / 抗核抗体 / ミクログリア / スプライシング / 感情障害 / 統合失調症 / クロマチン / 核タンパク質 / 膵臓ガン患者の延命 / 延命を可能にする遺伝子変異 / がん / RBM10のWikipedia改訂 / RBM10の総説執筆 / Wikipediaの全面改訂 / 当該遺伝子の総説執筆 / Splicing 制御 / 原著論文 IJMSに発表 / RBM10 遺伝子総説 / Wikipedia (英語版)全面改訂 / 総説 RBM10 / 細胞内シグナル伝達 / 制御キナーゼ / コンフォメーション / タンパク相互作用 / 構造解析 / CRM1非依存的核外輸送 / pS727-依存的非活性化機序 / pY705-SH2 結合 / 活性化／非活性化サイクル / 核外輸送 / チロシン脱リン酸化 / 非活性化機序 / 核外輸送系 / コンフォメーション変化 / pS727 / pY705-SH2 構造 / STAT3 / 視力障害 / 常染色体劣性遺伝 / ミスセンス変異 / チロシナーゼ / 小胞体 / ライソゾーム病 / メラニン / 色素異常症 / ケミカルシャペロン / 遺伝性皮膚疾患 / 眼皮膚白皮症 / RBM10異常に由来する疾病群 / RBM10異常と細胞病態 / RBM10標的転写産物の網羅的同定 / X-linked 遺伝子 / 細胞内RBM10レベルの制御機構 / RBM10によるG2/M期arrest / 細胞分裂制御 / RBM10活性の制御機構 / RBM10異常による細胞病態と疾病 / RBM10が関わる細胞内過程 / RBM10標的遺伝子の同定 / 選択的スプライシング / RBM10制御下の遺伝子群 / RBM10/ S1-1 / C2H2 Zn finger / 難病治療 / 難病 / 遺伝性疾患 / リードスルー / アミノグリコシド / ナンセンス変異 / nonsense mutation / read-through / aminoglycoside / genetic disorder / albinism Less

選択的スプライシング制御因子RBM10欠損による精子形成不全の分子機序解明Principal Investigator
- Principal Investigator
  
  國本浩之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka Metropolitan University
マルチオミクスを用いた生体レジリエンスにおける老化統括制御分子の包括的解析
- Principal Investigator
  
  安田邦彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Teikyo University
細胞核ダイナミクスの分子機能に着目した抗核抗体関連精神疾患の解明
- Principal Investigator
  
  山本直樹
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  International University of Health and Welfare
Elucidation of the pathogenesis of azoospermia caused by deficiency of the RNA-binding protein RBM10 and exploration of treatment methodsPrincipal Investigator
- Principal Investigator
  
  Kunimoto Hiroyuki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
Mutations for life lengthening of pancreatic cancer patients: mechanism and proposed theory for practice
- Principal Investigator
  
  INOUE Akira
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
Fate determination of nuclear STAT3
- Principal Investigator
  
  Nakajima Koichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka City University
Chemical chaperone therapy for oculocutaneous albinism
- Principal Investigator
  
  Fukai Kazuyoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Osaka City University
Unified elucidation of cell pathology of various diseases stemming from alternative splicing regulator RBM10
- Principal Investigator
  
  Inoue Akira
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Osaka City University
Pharmacological treatment of oculocutaneous albinism type 1 by read-though effect
- Principal Investigator
  
  FUKAI KAZUYOSHI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Osaka City University

All 2023 2021 2020 2019 2018 2017 2016 Other

All Journal Article Presentation

[Journal Article] Sequestration of RBM10 in Nuclear Bodies: Targeting Sequences and Biological Significance2021
- Author(s)
  Wang Ling-Yu、Xiao Sheng-Jun、Kunimoto Hiroyuki、Tokunaga Kazuaki、Kojima Hirotada、Kimura Masatsugu、Yamamoto Takahiro、Yamamoto Naoki、Zhao Hong、Nishio Koji、Tani Tokio、Nakajima Koichi、Sunami Kishiko、Inoue Akira
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 19 Pages: 10526-10526
- DOI
  10.3390/ijms221910526
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08327, KAKENHI-PROJECT-19K08378, KAKENHI-PROJECT-21K06174, KAKENHI-PROJECT-21K07557
[Journal Article] RBM10 regulates centriole duplication in HepG2 cells by ectopically assembling PLK4‐STIL complexes in the nucleus2020
- Author(s)
  Kunimoto Hiroyuki、Inoue Akira、Kojima Hirotada、Yang Junhao、Zhao Hong、Tsuruta Daisuke、Nakajima Koichi
- Journal Title
  
  Genes to Cells
  
  Volume: 25(2) Issue: 2 Pages: 100-110
- DOI
  10.1111/gtc.12741
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08327, KAKENHI-PROJECT-19K08378
[Journal Article] Phospho-Ser727 triggers a multistep inactivation of STAT3 by rapid dissociation of pY705?SH2 through C-terminal tail modulation2020
- Author(s)
  Yang Junhao、Kunimoto Hiroyuki、Katayama Bumpei、Zhao Hong、Shiromizu Takashi、Wang Lingyu、Ozawa Toshiyuki、Tomonaga Takeshi、Tsuruta Daisuke、Nakajima Koichi
- Journal Title
  
  International Immunology
  
  Volume: 32(2) Issue: 2 Pages: 73-88
- DOI
  10.1093/intimm/dxz061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08327, KAKENHI-PROJECT-17K08639
[Journal Article] Targeting of RBM10 to S1-1 Nuclear Bodies: Targeting Sequences and its Biological Significance2019
- Author(s)
  L.-Y. Wang, S.-J. Xiao, H. Kunimoto, K. Tokunaga, H. Kojima, M. Kimura, T. Yamamoto, N.Yamamoto, Z. Hong, K. Nishio, H Yamane, T. Tani, K. Nakajima, H. Iguchi, and A. Inoue
- Journal Title
  
  bioRkiv
  
  Volume: -
- DOI
  10.1101/516831
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05569
[Journal Article] The Molecular Basis of Chemical Chaperone Therapy for Oculocutaneous Albinism Type 1A2018
- Author(s)
  Ayako Teramae, Yui Kobayashi, Hiroyuki Kunimoto, Koichi Nakajima, Tamio Suzuki, Daisuke Tsuruta and Kazuyoshi Fukai
- Journal Title
  
  J Invest Dermatol
  
  Volume: 139 Issue: 5 Pages: 1143-1149
- DOI
  10.1016/j.jid.2018.10.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10170, KAKENHI-PROJECT-19K08327
[Presentation] 細胞核RNAスプライシング制御因子RBM10の中枢神経系及び末梢組織における発現と機能2023
- Author(s)
  山本直樹、中谷善彦、樫村剛、熊谷望海、須藤千晴、塙雄大、生井莉奈子、黒川信、國本浩之、井上晃
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K08784
[Presentation] 細胞核RNAスプライシング制御因子RBM10の中枢神経系及び末梢組織における発現と機能2023
- Author(s)
  山本直樹、中谷善彦、樫村剛、熊谷望海、須藤千晴、塙雄大、生井莉奈子、黒川信、國本浩之、井上晃
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08327
[Presentation] 細胞核RNAスプライシング制御因子RBM10の中枢神経系及び末梢神経組織における発現と機能2023
- Author(s)
  山本直樹, 中谷善彦, 樫村剛, 熊谷望海, 須藤千晴, 塙裕大, 生井莉奈子, 黒川信, 國本浩之, 井上晃
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-21K07557
[Presentation] Tetramer-based model of STAT3 activation-inactivation2019
- Author(s)
  Lingyu Wang, Hong Zhao, Junhao Yang, Hiroyuki Kunimoto, Koichi Nakajima
- Organizer
  第48回　日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K08327
[Presentation] Tetramer-based model of STAT3 activation-inactivation2019
- Author(s)
  Wang Lingyu, Zhao Hong, Yang Junhao, Kunimoto Hiroyuki, Nakajima Koichi
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K08639
[Presentation] RBM10はHepG2において中心小体複製に関わる新規の調節因子である2019
- Author(s)
  國本浩之, 井上晃, 趙虹, 中嶋弘一
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K08327
[Presentation] RBM10はHepG2において中心小体複製に関わる新規の調節因子である.2019
- Author(s)
  國本浩之, 井上晃, 趙虹, 中嶋弘一
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K08378
[Presentation] Dissociation of STAT3 C-terminal tail from its own SH2 is critical for phosphoSer727-dependent STAT3 inactivation2018
- Author(s)
  Yang Junhao, Kunimoto Hiroyuki, Zhao Hong, Wang Lingyu, Nakajima Koichi
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K08639
[Presentation] Molecular Basis Of Chemical Chaperone Therapy For2017
- Author(s)
  Teramae A, Kobayashi Y, Kunimoto H et al
- Organizer
  23rd International Pigment Cell Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10170
[Presentation] RBM10による中心小体形成の制御機序について2017
- Author(s)
  國本浩之、趙虹、井上晃、中嶋弘一
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K05569
[Presentation] A basic in vitro study of novel therapy for oculocutaneous albinism type 12017
- Author(s)
  Teramae A, Kobayashi Y, Fukai K, Kunimoto H, Nakajima K, Suzuki T, Tsuruta D
- Organizer
  76th annual meeting of the Society of Investigative Dermatology
- Place of Presentation
  Oregon Convention Center（アメリカ合衆国ポートランド）
- Year and Date
  2017-04-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10170
[Presentation] RBM10の活動度を制御する自己調節機構： S1-1 NB-targeting2017
- Author(s)
  井上晃, 國本浩之, 王凌宇, 肖勝軍, 小島裕正, 山本隆博, 山本直樹, 木村政継, 徳永和明, 谷時雄, 中嶋弘一, 井口広義
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K05569
[Presentation] A basic in vitro study of novel therapy for oculocutaneous albinism type 12017
- Author(s)
  Fukai K, Teramae A, Kobayashi Y, Kunimoto H, Nakajima K, Suzuki T, Tsuruta D
- Organizer
  分子皮膚科フォーラム
- Place of Presentation
  ベルサール東京日本橋（東京都中央区）
- Year and Date
  2017-04-14
- Data Source
  KAKENHI-PROJECT-16K10170
[Presentation] Fate decision of activated STAT3 for nuclear accumulation or export through regulated multiple conformational changes.2017
- Author(s)
  Yang Junhao, Kunimoto Hiroyuki, Katayama Bumpei, Wang Lingyu, Zhao Hong, Ozawa Toshiyuki, Tsuruta Daisuke, Nakajima Koichi
- Organizer
  5th Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08639
[Presentation] A basic in-vitro study of novel therapy for oculocutaneous albinism type12017
- Author(s)
  Teramae A, Kobayashi Y, Kunimoto H et al
- Organizer
  Society for Investigative Dermatology 76th Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10170
[Presentation] Subcellular localization of tyrosinase of R77Q, H211Y, and P431L mutants in lentivirus transfected HeLa cell2016
- Author(s)
  Teramae A, Kobayashi Y, Fukai K, Kunimoto H, Nakajima K, Suzuki T, Tsuruta D
- Organizer
  第41回日本研究皮膚科学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-12-09
- Data Source
  KAKENHI-PROJECT-16K10170
[Presentation] RBM10過剰発現による増殖抑制機序の解析2016
- Author(s)
  國本浩之、趙虹、井上晃、中嶋弘一
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K05569
[Presentation] Intracellular distribution of tyrosinase of R77Q, H211Y and P431L mutants2016
- Author(s)
  Teramae A, Kobayashi Y, Fukai K, Kunimoto H, Nakajima K, Suzuki T, Tsuruta D
- Organizer
  日本色素細胞学会
- Place of Presentation
  岐阜大学サテライトキャンパス（岐阜県岐阜市）
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PROJECT-16K10170
[Presentation] OCA1白皮症患者の薬物治療―リードスルー効果によるナンセンス変異回避の研究
- Author(s)
  梅香路　綾乃，國本　浩之，中嶋　弘一，鈴木　民夫,鶴田　大輔
- Organizer
  日本皮膚科学会
- Place of Presentation
  京都国際会議場（京都市）
- Year and Date
  2014-05-30 – 2014-06-01
- Data Source
  KAKENHI-PROJECT-25670504
[Presentation] Pharmacological treatment of oculocutaneous albinism type 1 by read-though effect
- Author(s)
  Umekoji A, Kunimoto H, Nakajima K, Suzuki T, Tsuruta D, Fukai K
- Organizer
  日本人類遺伝学会
- Place of Presentation
  タワーホテル船堀（東京）
- Year and Date
  2014-11-19 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25670504

1. Inoue Akira (50109857)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. Nakajima Koichi (00227787)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
3. 山本直樹 (70312296)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. FUKAI KAZUYOSHI (20244642)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. 濱崎考史 (40619798)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 趙虹 (10596183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 安田邦彦 (50278446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 森亮一 (30509310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUNIMOTO Hiroyuki 國本 浩之

國本 浩之 クニモト ヒロユキ

Research Projects

Research Products

Co-Researchers

選択的スプライシング制御因子RBM10欠損による精子形成不全の分子機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マルチオミクスを用いた生体レジリエンスにおける老化統括制御分子の包括的解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞核ダイナミクスの分子機能に着目した抗核抗体関連精神疾患の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathogenesis of azoospermia caused by deficiency of the RNA-binding protein RBM10 and exploration of treatment methodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mutations for life lengthening of pancreatic cancer patients: mechanism and proposed theory for practice

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fate determination of nuclear STAT3

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical chaperone therapy for oculocutaneous albinism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Unified elucidation of cell pathology of various diseases stemming from alternative splicing regulator RBM10

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pharmacological treatment of oculocutaneous albinism type 1 by read-though effect

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sequestration of RBM10 in Nuclear Bodies: Targeting Sequences and Biological Significance2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RBM10 regulates centriole duplication in HepG2 cells by ectopically assembling PLK4‐STIL complexes in the nucleus2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phospho-Ser727 triggers a multistep inactivation of STAT3 by rapid dissociation of pY705?SH2 through C-terminal tail modulation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting of RBM10 to S1-1 Nuclear Bodies: Targeting Sequences and its Biological Significance2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Molecular Basis of Chemical Chaperone Therapy for Oculocutaneous Albinism Type 1A2018

KUNIMOTO Hiroyuki 國本浩之

國本浩之クニモトヒロユキ