OHNISHI TETSUO 大西哲生

… Alternative Names

大西哲生オオニシテツオ

OHNISHI Tetsuo 大西哲生

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Researcher Number	80373281
Other IDs	https://orcid.org/0000-0002-6696-9725
External Links
Affiliation (Current)	2022: 東京医科歯科大学, 難治疾患研究所, 助教
Affiliation (based on the past Project Information) *help	2022: 東京医科歯科大学, 難治疾患研究所, 助教 2018 – 2020: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 副チームリーダー 2017: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 副チームリーダー 2015 – 2017: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 副チームリーダー 2013 – 2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 2004 – 2012: 独立行政法人理化学研究所, 分子精神科学研究チーム, 研究員
Review Section/Research Field	Principal Investigator Psychiatric science / Neurophysiology / General neuroscience / Basic Section 52030:Psychiatry-related Except Principal Investigator Psychiatric science / Biological Sciences / Medium-sized Section 52:General internal medicine and related fields / Basic Section 52030:Psychiatry-related
Keywords	Principal Investigator 統合失調症 / 双極性障害 / モデルマウス / ノックアウトマウス / 行動実験 / 転写因子 / 染色体転座 / イノシトール枯渇仮説 / リチウム / IMPA1 … More / IMPA2 / イノシトールモノフォスファターゼ / マイクロアレイ / 染色体異常 / 扁桃体 / 均衡型染色体転座 / 気分安定薬 / IMPase / 双極件障害 / DISC1 / ドーパミン / グルタミン酸 / MK801 / methylphenidate / amphetamine / Ldb2 / 恐怖条件付け / iPS細胞 / 予測妥当性 / 抗精神病薬 / 脳波 / 熱性けいれん / 躁 / うつ / イノシトール / モデル動物 / 躁うつ病 / イノシトールリン酸 / bipolar disorder / lithium / inositol monophosphatase / schizophrenia / febrile seizures / inositol depletion hypothesis / mania / depression / 均衡型転座 / ChIP seq / 電気生理 / レアバリアント / クロマチン免疫沈降 / 発現制御 / 脳神経疾患 / 脳・神経 / マウス / ChIP-seq … More Except Principal Investigator 統合失調症 / 遺伝子 / ゲノム / IMPase / 遺伝子改変マウス / リチウム / 気分安定薬 / 双極性障害 / モデルマウス / 脳・神経疾患 / シグナル伝達 / マイクロアレイ / カルボニルストレス / 酸化ストレス / iPS細胞 / 脳神経疾患 / 硫化水素 / calcineurin / protein phosphatase / PPP3CC / SNP / schizophrenia / Impa1 / Impa2 / SNPChip / 死後脳 / オートファジー / イノシトール枯渇仮説 / LC3 / イノシトールモノフォスファターゼ / 遺伝子変異 / グリオキサラーゼ / ビタミン / ストレス / 脳・神経 / 遺転子 / GABAA受容体 / カナビノイド受容体 / DNAChip / シグナルパスウェイ / 22q11.2欠失 / 神経発達 / 終末糖化産物 / miRNA / コピー数多型 / 22q11.2欠失症候群 / 神経分化 / 22q11.2欠乏症候群 / DGCR8 / neurosphere / 分化 / 生理活性 / ガスメディエーター / マウス近交系 / プレパルス抑制 / ゲノム編集 / Mpst / ノックアウト / トランスジェニック / プロテオーム / 細胞・組織 / 生体分子 / 次世代シークエンサー / 主要組織適合遺伝子複合体 / 伝達連鎖不平衡テスト / 関連研究 / 染色体8p / 遺伝連鎖不平衡テスト / case-control study / transmission disequilibrium test / association study / 躁うつ病 / 熱性けいれん / ENU / inositol monophosphatase / ノックアウトマウス / gene-driven mutagenesis / トランスジェニックマウス / lithium / mood stabilizer / bipolar disorder / gene manipulated mice / inositol / SNPチップ / 連鎖不平衡 / linkage diseauilibrium / genome / gene / エネルギー代謝 / エピジェネティックス / 炎症 / 還元ストレス / イオウ / 炎症ストレス / DNAメチル化 / poly I:C / オリゴデンドロサイト / RXR / 核内受容体 / 脂質生化学 / スフィンゴ脂質 / リン脂質 / 白質 / 精神疾患モデルマウス / 精神疾患 / 脳梁 / 脳発達期 / 栄養 / DOHaD / PPAR-alpha Less

脳発達期の栄養恒常性破綻による統合失調症病態形成メカニズムの解明
- Principal Investigator
  
  前川素子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tohoku University
Study on pathophysiological mechanism of schizophrenia with altered sphingolipid metabolism
- Principal Investigator
  
  Yoshikawa Takeo
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Institute of Physical and Chemical Research
新規遺伝子発現調節メカニズムLDB2-EGR/ARC系と精神疾患Principal Investigator
- Principal Investigator
  
  大西哲生
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Institute of Physical and Chemical Research
Exploration of mechanism for schizophrenia origin and longitudinal consequence
- Principal Investigator
  
  Yoshikawa Takeo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Institute of Physical and Chemical Research
Involvement of the transcription complex in higher brain functionPrincipal Investigator
- Principal Investigator
  
  Ohnishi Tetsuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Institute of Physical and Chemical Research
Pathology of schizophrenia by regulation of oligodendrocyte related-genes
- Principal Investigator
  
  Maekawa Motoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Institute of Physical and Chemical Research
A role of MPST in the pathophysiology of psychiatric illnesses, in particular schizophrenia
- Principal Investigator
  
  YOSHIKAWA TAKEO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Institute of Physical and Chemical Research
次世代シークエンサーによる統合失調症脆弱性HLA領域の配列決定
- Principal Investigator
  
  山田和男
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of pathologic mechanism using iPS cells derived from schizophrenia patients
- Principal Investigator
  
  YOSHIKAWA TAKEO
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
Gene networks governed by DISC-M and schizophreniaPrincipal Investigator
- Principal Investigator
  
  OHNISHI TETSUO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
The function and mechanism of GABAergic signaling in schizophrenia
- Principal Investigator
  
  YAMADA Kazuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of Dicc-M KO mice to reveal the pathogenesis of schizophreniaPrincipal Investigator
- Principal Investigator
  
  OHNISHI Tetsuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
The genetic analysis of calcineurin signaling pathway in schizophrenia.
- Principal Investigator
  
  YAMADA Kazuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
Research on pathophysiology and mechanisms to develop carbonyl stress-related schizophrenia
- Principal Investigator
  
  ARAI Makoto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Relationship between therapeutic efficacy of mood stabilizers and cellular inositolPrincipal Investigator
- Principal Investigator
  
  OHNISHI Tetsuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
オートファジーと気分安定薬の作用機序
- Principal Investigator
  
  吉川武男
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
Genome-wide association study of schizophrenic patients on 100K SNP Chip.
- Principal Investigator
  
  KAZUO Yamada
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
Inositol-metabolizing enzyme gene-manipulated mice towards molecular dissection of pathophysiology of mental disorders.
- Principal Investigator
  
  YOSHIKAWA Takeo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  RIKEN
Biochemical characterization of the IMPA2 gene productPrincipal Investigator
- Principal Investigator
  
  OHNISHI Tetsuo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  RIKEN
Involvement of calcineurin-related genes in schizophrenia.
- Principal Investigator
  
  YAMADA Kazuo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  RIKEN

[Book] 精神薬療研究年報第45集2013
- Author(s)
  豊島学、前川素子、大西哲生、市川智恵、岡田洋平、赤松和土、糸川昌成、岡野栄之、吉川武男
- Total Pages
  184
- Publisher
  （公財）先進医薬研究振興財団
- Data Source
  KAKENHI-PLANNED-24116002
[Book] 論文ができてしまう!疾患モデルマウス表現型解析指南(編集・山村研一、若菜茂晴)2011
- Author(s)
  大西哲生、吉川武男(分担)
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-21591535
[Book] 疾患モデルマウスと表現型解析～これだけ調べれば論文が書ける～2011
- Author(s)
  大西哲生、吉川武男
- Total Pages
  5
- Publisher
  中山書店(印刷中)
- Data Source
  KAKENHI-PROJECT-21591535
[Book] 第三章脳神経系:精神疾患2011
- Author(s)
  大西哲生、吉川武男
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-21591535
[Journal Article] Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia2021
- Author(s)
  Ohnishi T, Kiyama Y, Arima-Yoshida F, Kadota M, Ichikawa T, Yamada K, Watanabe A, Ohba H, Tanaka K, Nakaya A, Horiuchi Y, Iwayama Y, Toyoshima M, Ogawa I, Shimamoto-Mitsuyama C, Maekawa M, Balan S, Arai M, Miyashita M, Toriumi K, et al.
- Journal Title
  
  EMBO Mol Med.
  
  Volume: 13
- DOI
  10.15252/emmm.202012574
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06977, KAKENHI-PROJECT-19K07799, KAKENHI-PROJECT-19K08023, KAKENHI-PROJECT-20K07934, KAKENHI-PUBLICLY-19H04876, KAKENHI-PUBLICLY-19H04887, KAKENHI-PROJECT-19H03328, KAKENHI-PROJECT-19H03589, KAKENHI-PROJECT-18K07578, KAKENHI-PROJECT-19H03321, KAKENHI-PROJECT-19K06629
[Journal Article] Peroxisome proliferator-activated receptor a as a novel therapeutic target for schizophrenia2020
- Author(s)
  Wada, Maekawa, Ohnishi et al.
- Journal Title
  
  EbioMedicine
  
  Volume: 62 Pages: 103130-103130
- DOI
  10.1016/j.ebiom.2020.103130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07934, KAKENHI-PLANNED-18H05430, KAKENHI-PROJECT-18H02753, KAKENHI-PROJECT-19H03589, KAKENHI-PROJECT-18K07578
[Journal Article] LDB2 locus disruption on 4p16.1 as a risk factor for schizophrenia and bipolar disorder2020
- Author(s)
  Horiuchi, Ichikawa, Ohnishi et al.
- Journal Title
  
  Human Genomu Variation
  
  Volume: 7 Pages: 1-3
- DOI
  10.1038/s41439-020-00117-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07934, KAKENHI-PUBLICLY-19H04887, KAKENHI-PROJECT-19H03589, KAKENHI-PROJECT-20H03608
[Journal Article] Lipid Pathology of the Corpus Callosum in Schizophrenia and the Potential Role of Abnormal Gene Regulatory Networks with Reduced Microglial Marker Expression2020
- Author(s)
  Shimamoto-Mitsuyama Chie、Nakaya Akihiro、Esaki Kayoko、Balan Shabeesh、Iwayama Yoshimi、Ohnishi Tetsuo、Maekawa Motoko、Toyota Tomoko、Dean Brian、Yoshikawa Takeo
- Journal Title
  
  Cerebral Cortex
  
  Volume: 31 Pages: 448-462
- DOI
  10.1093/cercor/bhaa236
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06629, KAKENHI-PROJECT-20K20388, KAKENHI-PROJECT-18K07578
[Journal Article] Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis.2019
- Author(s)
  Toyoshima M, Jiang X, Ogawa T, Ohnishi T, Yoshihara S, Balan S, Yoshikawa T, Hirokawa N.
- Journal Title
  
  Life Science Alliance
  
  Volume: 2
- DOI
  10.26508/lsa.201900478
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07616, KAKENHI-PROJECT-19K08023, KAKENHI-PROJECT-19K08084, KAKENHI-PROJECT-20K20388, KAKENHI-PROJECT-18H03579
[Journal Article] Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology2019
- Author(s)
  Ide M, Ohnishi T, Toyoshima M, Itokawa M, Hirokawa N, Kunii Y, Kakita A, Yabe H, Iwamoto K, Meno K, Katagiri T, Dean B, Uchida K, Kimura H, Yoshikawa T.
- Journal Title
  
  EMBO Mol Med
  
  Volume: 11(12) Issue: 12
- DOI
  10.15252/emmm.201910695
- NAID
  120007132855
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08331, KAKENHI-PROJECT-17K08613, KAKENHI-PROJECT-19K08023, KAKENHI-PROJECT-19K08084, KAKENHI-PROJECT-18K15520, KAKENHI-PLANNED-18H05430, KAKENHI-PROJECT-17H01574, KAKENHI-PROJECT-18H02753, KAKENHI-PROJECT-19H03410, KAKENHI-PROJECT-19H03589, KAKENHI-PROJECT-20K20388, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K07578, KAKENHI-PROJECT-19K17122, KAKENHI-PROJECT-18H03579
[Journal Article] Investigation of betaine as a novel psychotherapeutic for schizophrenia2019
- Author(s)
  Ohnishi T, Balan S, Toyoshima M, Maekawa M, Ohba H, Watanabe A, Iwayama Y, Hisano Y, Nagaoka A, Hino M, Kunii Y, Kakita A, Yabe H, Yoshikawa T.
- Journal Title
  
  EBioMedicine
  
  Volume: 45 Pages: 432-446
- DOI
  10.1016/j.ebiom.2019.05.062
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08023, KAKENHI-PROJECT-19K08084, KAKENHI-PROJECT-19K22591, KAKENHI-PROJECT-18K15522, KAKENHI-ORGANIZER-18H05428, KAKENHI-PROJECT-20K20388, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K07578, KAKENHI-PROJECT-19K17122
[Journal Article] Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes.2017
- Author(s)
  Maekawa M、Watanabe A、Iwayama Y、Kimura T、Hamazaki K、Balan S、Ohba H、Hisano Y、Nozaki Y、Ohnishi T、Toyoshima M、Shimamoto C、Iwamoto K、Bundo M、Osumi N、Takahashi E、Takashima A、Yoshikawa T
- Journal Title
  
  Translational Psychiatry.
  
  Volume: 7
- DOI
  10.1038/tp.2017.182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19372, KAKENHI-PLANNED-16H06399, KAKENHI-PLANNED-16H06530, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15H04891, KAKENHI-PROJECT-15K09814
[Journal Article] Schizophrenia patient-derived induced pluripotent stem cells exhibit changes in neurogenic and gliogenic competences.2016
- Author(s)
  Toyoshima M, Akamatsu W, Okada Y, Ohnishi T, Balan S, Hisano Y, Iwayama Y, Toyota T, Matsumoto T, Itasaka N, Sugiyama S, Tanaka M, Yano M, Dean B, Okano H, Yoshikawa T
- Journal Title
  
  Translational Psychiatry
  
  Volume: 6
- DOI
  10.1038/tp.2016.206
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01568, KAKENHI-ORGANIZER-24116001, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-25640038, KAKENHI-PROJECT-15K09849, KAKENHI-PROJECT-16K07247, KAKENHI-PROJECT-15H04278
[Journal Article] Sequencing and expression analyses of the synaptic lipid raft adapter gene PAG1 in schizophrenia.2015
- Author(s)
  Balan S, Iwayama Y, Yamada K, Toyota T, Ohnishi T, Toyoshima M, Shimamoto C, Ide M, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Yoshikawa T, Maekawa M.
- Journal Title
  
  J Neural Transmission
  
  Volume: 122 Pages: 477-485
- DOI
  10.1007/s00702-014-1269-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293267, KAKENHI-PROJECT-26860954, KAKENHI-PROJECT-15K09849, KAKENHI-PLANNED-24116002, KAKENHI-ORGANIZER-24116001
[Journal Article] Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.2015
- Author(s)
  Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T
- Journal Title
  
  Sci Rep
  
  Volume: 5 Pages: 1-14
- DOI
  10.1038/srep16239
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09814, KAKENHI-PROJECT-15K09849, KAKENHI-PROJECT-26350122, KAKENHI-PROJECT-15K15436, KAKENHI-PROJECT-25640038, KAKENHI-PUBLICLY-15H01568, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-15H04278, KAKENHI-PROJECT-25461762, KAKENHI-ORGANIZER-24116001
[Journal Article] Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses2015
- Author(s)
  Maekawa M, Yamada K, Toyoshima M, Ohnishi T, Iwayama Y, Shimamoto C, Toyota T, Nozaki Y, Balan S, Matsuzaki H, Iwata Y, Suzuki K, Miyashita M, Kikuchi M, Kato M, Okada Y, Akamatsu W, Mori N, Owada Y, Itokawa M, Okano H, Yoshikawa T.
- Journal Title
  
  Biol Psychiatry.
  
  Volume: 3223 Pages: 00570-00578
- DOI
  10.1016/j.biopsych.2014.07.025
- NAID
  40020643113
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24116001, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-24390282, KAKENHI-PUBLICLY-25110730, KAKENHI-PROJECT-25640038, KAKENHI-PROJECT-25670520, KAKENHI-PROJECT-25861037, KAKENHI-PROJECT-26293267, KAKENHI-PROJECT-15K09849, KAKENHI-PROJECT-26350122, KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-25253074, KAKENHI-PROJECT-25461762
[Journal Article] Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects.2014
- Author(s)
  2.Balan S, Iwayama Y, Maekawa M, Toyota T, Ohnishi T, Toyoshima M, Shimamoto C, Esaki K, Yamada K, Iwata Y, Suzuki K, Ide M, Ota M, Fukuchi S, Tsujii M, Mori N, Shinkai Y. and Yoshikawa T.
- Journal Title
  
  Mol Autism
  
  Volume: 5 Pages: 49-49
- DOI
  10.1186/2040-2392-5-49
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J05809, KAKENHI-ORGANIZER-24116001, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-25461759, KAKENHI-PROJECT-26293267
[Journal Article] Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies.2014
- Author(s)
  Shimamoto C, Ohnishi T, Maekawa M, Watanabe A, Ohba H, Arai R, Iwayama Y, Hisano Y, Toyota T, Toyoshima M, Suzuki K, Shirayama Y, Nakamura K, Mori N, Owada Y, Kobayashi T, Yoshikawa T.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 23 Pages: 6495-6511
- DOI
  10.1093/hmg/ddu369
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24116001, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-24390047, KAKENHI-PROJECT-26350122
[Journal Article] Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.2014
- Author(s)
  Ohnishi T, Murata T, Watanabe A, Hida A, Ohba H, Iwayama Y, Mishima K, Gondo Y, Yoshikawa T
- Journal Title
  
  J Biol Chem.
  
  Volume: 289(15) Pages: 10785-10796
- DOI
  10.1074/jbc.m113.536706
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390293, KAKENHI-ORGANIZER-24116001, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-24591737, KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25430100
[Journal Article] Defective Craniofacial Development and Brain Function in a Mouse Model for Depletion of Intracellular Inositol Synthesis.2014
- Author(s)
  Ohnishi T, Murata T, Watanabe A, Hida A, Ohba H, Iwayama Y, Mishima K, Gondo Y, Yoshikawa T
- Journal Title
  
  J Biol Chemistry
  
  Volume: 289 Pages: 10785-10796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24116002
[Journal Article] Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies.2013
- Author(s)
  Balan S, Yamada K, Hattori E, Iwayama Y, Toyota T, Ohnishi T, Maekawa M, Toyoshima M, Iwata Y, Suzuki K, Kikuchi M, Yoshikawa T
- Journal Title
  
  PLoS One
  
  Volume: 8(7)
- DOI
  10.1371/journal.pone.0070302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390293, KAKENHI-PROJECT-24591737
[Journal Article] A population-specific uncommon variant in GRIN3A associated with schizophrenia2013
- Author(s)
  Takata A, Iwayama Y, Fukuo Y, Ikeda M, Okochi T, Maekawa M, Toyota T, YamadaK, Hattori E, Ohnishi T, Toyoshima M, Ujike H, Inada T, Kunugi H, Ozaki N, Nanko S, Nakamura K, Mori N, Kanba S, Iwata N, Kato T, Yoshikawa T.
- Journal Title
  
  Biological Psychiatry
  
  Volume: 73(6) Pages: 532-539
- DOI
  10.1016/j.biopsych.2012.10.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390226, KAKENHI-PROJECT-23390293, KAKENHI-PROJECT-25253072, KAKENHI-ORGANIZER-24116001
[Journal Article] Lack of association of EGR2 variants with bipolar disorder in Japanese population.2013
- Author(s)
  Balan S, Yamada K, Iwayama Y, Toyota T, Ohnishi T, Maekawa M, Toyoshima M, Iwata Y, Suzuki K, Kikuchi M, Ujike H, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Kato T, Yoshikawa T
- Journal Title
  
  Gene
  
  Volume: 526(2) Pages: 246-250
- DOI
  10.1016/j.gene.2013.05.055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390293, KAKENHI-PROJECT-24591737, KAKENHI-PLANNED-25117010, KAKENHI-PROJECT-25253072
[Journal Article] Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population2012
- Author(s)
  Yamada K, Iwayama Y, Toyota T, Ohnishi T, Ohba H, Maekawa M, Yoshikawa T
- Journal Title
  
  Hum Genet
  
  Volume: 131(3) Pages: 443-451
- DOI
  10.1007/s00439-011-1089-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390293
[Journal Article] Genome-wide association study of schizophrenia2011
- Author(s)
  Kazuo Yamada
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- DOI
  10.1371/journal.pone.0020468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591307, KAKENHI-PROJECT-23249060, KAKENHI-PROJECT-23390293
[Journal Article] Ablation of Mrds1/Ofcc1 induces hyper-gamma-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice2011
- Author(s)
  Ohnishi, T., et al
- Journal Title
  
  PLoS One
  
  Volume: 6(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390293
[Journal Article] Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice2011
- Author(s)
  Ohnishi T, Yamada K, Watanabe A, Ohba H, Sakaguchi T, Honma Y, Iwayama Y, Toyota T, Maekawa M, Watanabe K, Detera-Wadleigh SD, Wakana S, Yoshikawa T
- Journal Title
  
  PLoS One
  
  Volume: 6(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591535
[Journal Article] Genome-wide Association Study of Schizophrenia in Japanese Population.2011
- Author(s)
  Yamada K, Iwayama Y, Hattori E, Iwamoto K, Toyota T, Ohnishi T, Ohba H, Maekawa M, Kato T, Yoshikawa T
- Journal Title
  
  PLoS ONE. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390316
[Journal Article] Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice2011
- Author(s)
  Ohnishi T, Yamada K, Watanabe A, Ohba H, Sakaguchi T, Honma Y, Iwayama Y, Toyota T, Maekawa M, Watanabe K, Detera-Wadleigh SD, Wakana S, Yoshikawa T
- Journal Title
  
  PLoS One
  
  Volume: 6(12)
- DOI
  10.1371/journal.pone.0029499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390293
[Journal Article] Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia.2010
- Author(s)
  Maekawa M, Ohnishi T, Hashimoto K, Watanabe A, Iwayama Y, Ohba H, Hattori E, Yamada K, Yoshikawa T
- Journal Title
  
  J Neurochem. 115(6)
  
  Pages: 1374-1385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390316
[Journal Article] Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder.2010
- Author(s)
  Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T
- Journal Title
  
  Am J Med Genet B Neuropsychiatr Genet. 153B(2)
  
  Pages: 484-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390316
[Journal Article] Enhanced carbonyl stress in a subpopulation of schizophrenia2010
- Author(s)
  Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M
- Journal Title
  
  Arch Gen Psychiatry
  
  Volume: 67(6) Pages: 589-97
- NAID
  130005395360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591535
[Journal Article] Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SBMT1) in mice and in schizophrenia.2010
- Author(s)
  Maekawa, Ohnishi, et al.
- Journal Title
  
  J Neurochem
  
  Volume: 115 Pages: 1374-1385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591535
[Journal Article] Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia.2010
- Author(s)
  Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M.
- Journal Title
  
  Arch Gen Psychiatry. 67(6)
  
  Pages: 589-597
- NAID
  130005395360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591383
[Journal Article] Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia2010
- Author(s)
  Arai, Yuzawa, Nohara, Ohnishi, et al.
- Journal Title
  
  Arch Gen Psych
  
  Volume: 67 Pages: 589-597
- NAID
  130005395360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591535
[Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia : the Japanese population and meta-analysis.2010
- Author(s)
  Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T
- Journal Title
  
  Am J Med Genet B Neuropsychiatr Genet. 153B(6)
  
  Pages: 1221-1227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390316
[Journal Article] Analysis of strain-dependent prepulse inhibition points to a role for Shmt1(SHMT1) in mice and in schizophrenia2010
- Author(s)
  Maekawa M, Ohnishi T, Hashimoto K, Watanabe A, Iwayama Y, Ohba H, Hattori E, Yamada K, Yoshikawa T
- Journal Title
  
  J Neurochem
  
  Volume: 115(6) Pages: 1374-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591535
[Journal Article] Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA22010
- Author(s)
  Ohnishi, et al.
- Journal Title
  
  Reuroscience Research
  
  Volume: 67 Pages: 86-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591535
[Journal Article] A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient.2009
- Author(s)
  Maekawa M, Iwayama Y, Nakamura K, Sato M, Toyota T, Ohnishi T, Yamada K, Miyachi T, Tsujii M, Hattori E, Maekawa N, Osumi N, Mori N, Yoshikawa T
- Journal Title
  
  Neurosci Lett. 462(3)
  
  Pages: 267-2671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390316
[Journal Article] Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations.2009
- Author(s)
  Yamada K, Hattori E, Iwayama Y, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Okazaki Y, Yoshikawa T
- Journal Title
  
  Am J Med Genet B Neuropsychiatr Genet. 150B(4)
  
  Pages: 508-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390316
[Journal Article] Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures2007
- Author(s)
  Arai R, Ito K, Ohnishi T, Ohba H, Akasaka R, Bessho Y, Hanawa-Suetsugu K, Yoshikawa T, Shirouzu M, Yokoyama S
- Journal Title
  
  Proteins 67(3)
  
  Pages: 732-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591386
[Journal Article] A promoter haplotype of the inositol monophosphatase 2 gene(IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription.2007
- Author(s)
  Ohnishi T, et. al.
- Journal Title
  
  Neuropsychopharmacology. 32(8)
  
  Pages: 1727-1737
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591321
[Journal Article] A promoter haplotype of the inositol monophosphatase 2 gene(IMPA2)at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcnption.2007
- Author(s)
  Ohnishi T, et. al.
- Journal Title
  
  Neuropsychopharmacology. 32(8)
  
  Pages: 1727-1737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591321
[Journal Article] Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.2007
- Author(s)
  Ohnishi T et al.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 637-646
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390323
[Journal Article] A promoter haplotype of the inositol monophosphatase 2 gene(IMPA2)at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription.2007
- Author(s)
  Ohnishi T, et. al.
- Journal Title
  
  Neurqpsychopharmacology 32(8)
  
  Pages: 1727-1737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591386
[Journal Article] Spatial expression patterns and biochemical properties distingUish a second myo-inositol monophosphatase IMPA2 from IMPA1.2007
- Author(s)
  Ohnishi T et al.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 637-646
- Data Source
  KAKENHI-PROJECT-17390323
[Journal Article] A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription2007
- Author(s)
  Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi H, Tatsumi M, Ozaki N, Iwata N, Sakamoto K, Iijima Y, Iwata Y, Tsuchiya KJ, Sugihara G, Nanko S, Osumi N, Detera-Wadleigh SD, Kato T, Yoshikawa T
- Journal Title
  
  Neuropsychopharmacology 32(8)
  
  Pages: 1727-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591386
[Journal Article] A promoter haplotype of the inositol monophosphatase 2 gene(IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription.2007
- Author(s)
  Ohnishi T, et. al.
- Journal Title
  
  Neuropsychopharmacology 32(8)
  
  Pages: 1727-1737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659295
[Journal Article] A promoter haplotype of the inositol monophosphatase 2 gene(IMPA2) at 18p11. 2 confers a possible risk for bipolar disorder by enhancing transcription.2007
- Author(s)
  Ohnishi T, et. al.
- Journal Title
  
  Neuropsychopharmacology. 32(8)
  
  Pages: 1727-1737
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591321
[Journal Article] Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.2007
- Author(s)
  Ohnishi T et al.
- Journal Title
  
  Biol. Chem. 282
  
  Pages: 637-646
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390323
[Journal Article] A promoter haplotype of inositol monophosphatase 2 gene (IMPA2) at 18p11.2 possibly confers risk for bipolar disorder by enhancing transcription.2007
- Author(s)
  Ohnishi T et al.
- Journal Title
  
  Neuropsychopharmacology Jan 24 [Epub ahead of print]
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390323
[Journal Article] Functional analysis of the IMPA2 gene product. (No.2)2006
- Author(s)
  Ohnishi T, Ohba H, Yoshikawa T
- Journal Title
  
  Ann.Rep.Mitsubishi Pharma Res.Found 38(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591175
[Journal Article] 精神疾患感受性候補遺伝子IMPA2の機能解析(その2)2006
- Author(s)
  大西哲生
- Journal Title
  
  精神薬療研究年報 38集(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591175
[Journal Article] Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder : relevance to neuronal network perturbation2006
- Author(s)
  Nakatani N, Hattori E, Ohnishi T et al.
- Journal Title
  
  Hum.Mol.Genet. 15
  
  Pages: 1949-1962
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591175
[Journal Article] 動物モデルを用いたうつの分子遺伝子学的アプローチ2005
- Author(s)
  吉川武男, 大西哲生
- Journal Title
  
  日本薬理学会誌 121(1)
  
  Pages: 25-32
- Data Source
  KAKENHI-PROJECT-16591175
[Journal Article] Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.2005
- Author(s)
  Yamada K, Ohnishi T, Hashimoto K, Ohba H, Iwayama-Shigeno Y, Toyoshima M, Okuno A, Takao H, Toyota T, Minabe Y, Nakamura K, Shimizu E, Itokawa M, Mori N, Iyo M, Yoshikawa T
- Journal Title
  
  Biol.Psychiatry 57
  
  Pages: 1493-1503
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591175
[Journal Article] 精神疾患感受性候補遺伝子IMPA2の機能解析2005
- Author(s)
  大西哲生ら
- Journal Title
  
  精神薬療研究年報 37
  
  Pages: 42-48
- Data Source
  KAKENHI-PROJECT-16591175
[Journal Article] 精神疾患感受性候補遺伝子IMPA2の機能解析2005
- Author(s)
  大西哲生
- Journal Title
  
  精神薬療研究年報 37集
  
  Pages: 42-48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591175
[Journal Article] Functional analysis of the IMPA2 gene product.2005
- Author(s)
  Ohnishi T, Ohba H, Sato T, Chung S.K, Hirabayashi Y, Yamada K, Shigeno Y, Furuichi T, Yoshikawa T
- Journal Title
  
  Ann.Rep.Mitsubishi Pharma Res.Found 37
  
  Pages: 42-48
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591175
[Journal Article] A promoter haplotype of inositol monophosphatase 2 gene (IMPA2) at 18p11.2 possibly confers risk for bipolar disorder by enhancing transcription.
- Author(s)
  Ohnishi T et al.
- Journal Title
  
  Neuropsychopharmacology (in press)
- Data Source
  KAKENHI-PROJECT-17390323
[Journal Article] Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia.
- Author(s)
  Ide M, Ohnishi M, Murayama M, Matsumoto I, Yamada K, Iwayama Y, Irena D, Toyota T, Asada T, Takashima A, Yoshikawa T
- Journal Title
  
  J.Neurochem. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591175
[Journal Article] Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression.
- Author(s)
  Yamada K, Hattori E, Iwayama Y, Ohnishi T, Ohba H, Toyota T, Takao H, Minabe Y, Nakatani N, Higuchi T, Detera-Wadleigh SD, Yoshikawa T
- Journal Title
  
  Biol.Psychiatry (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591175
[Journal Article] A promoter haplotype of inositol monophosphatase 2 gene (IMPA2) at 18p11.2 possibly confers risk for bipolar disorder by enhancing transcription.
- Author(s)
  Ohnishi T et al.
- Journal Title
  
  Neuropsychopharmacology (印刷中)(オンライン版で発表済み)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390323
[Presentation] カルボニルストレスによる神経発達異常のタンパク質分子病態解析2020
- Author(s)
  豊島学、蒋緒光、小川覚之、大西哲生、Shabeesh Balan、吉原壯悟、廣川信隆、吉川武男
- Organizer
  NPBPPP2020合同年会
- Data Source
  KAKENHI-PROJECT-20K20388
[Presentation] Dysregulated Lipid Metabolism in the Corpus Callosum From Schizophrenia Patients2020
- Author(s)
  Chie Shimamoto-Mitsuyama, Kayoko Esaki, Yoshimi Iwayama, Shabeesh Balan, Tetsuo Ohnishi, Motoko Maekawa, Tomoko Toyota, Brian Dean, Takeo Yoshikawa
- Organizer
  CINP 2021 Virtual World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20388
[Presentation] 脳梁における脂質代謝異常と統合失調症2020
- Author(s)
  島本知英、Shabeesh Balan、岩山佳美、江崎加代子、大西哲生、前川素子、Brian Dean、吉川武男
- Organizer
  NPBPPP2020合同年会
- Data Source
  KAKENHI-PROJECT-20K20388
[Presentation] Altered lipid metabolism of the corpus callosum of patients with schizophrenia2019
- Author(s)
  Chie Shimamoto-Mitsuyama, Kayoko Esaki, Tetsuo Ohnishi, Motoko Maekawa, Yoshimi Iwayama, Shabeesh Balan, Brian Dean and Takeo Yoshikawa
- Organizer
  6th Congress of AsCNP
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20388
[Presentation] カルボニルストレス性統合失調症におけるタンパク質分子病態解析2019
- Author(s)
  豊島学, 蒋緒光, 小川覚之, 大西哲生, 吉原壯悟, Shabeesh Balan, 吉川武男, 廣川信隆
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K20388
[Presentation] iPS細胞を用いた神経発達障害の分子病態の解明2019
- Author(s)
  豊島学, 大西哲生, 吉川武男
- Organizer
  第49回日本神経精神薬理学会
- Data Source
  KAKENHI-PROJECT-20K20388
[Presentation] カルボニルストレスによる神経発達異常の分子メカニズムの解明2019
- Author(s)
  豊島学, 大西哲生, 新井誠, 糸川昌成, 岡野栄之, 吉川武男
- Organizer
  第41回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-20K20388
[Presentation] 神経分化・発達におけるカルボニルストレスの影響2018
- Author(s)
  豊島学, 大西哲生, 新井誠,　糸川昌成, 岡野栄之, 吉川武男
- Organizer
  第40回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-20K20388
[Presentation] Polyunsaturated fatty acid deficiency during early neurodevelopmental stages can cause vulnerability to psychosis, through epigenetic changes in nuclear receptor genes2017
- Author(s)
  Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iyamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, Yoshikawa T
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K09814
[Presentation] 患者由来のiPS細胞を用いた神経発達障害に関わるmiRNAの分子病態の解明2017
- Author(s)
  豊島学, 赤松和土, 岡田洋平, 大西哲生, 岡野栄之, 吉川武男
- Organizer
  第12回日本統合失調症学会
- Place of Presentation
  米子コンベンションセンターBIG SHIP (鳥取)
- Data Source
  KAKENHI-PLANNED-24116002
[Presentation] A transcription regulator potentially involved in the pathogenesis of mental disorders2017
- Author(s)
  Tetsuo Ohnishi
- Organizer
  RIKEN Epigenetics 2017 in Tsukuba
- Place of Presentation
  理化学研究所つくばキャンパス（茨城県・つくば市）
- Year and Date
  2017-02-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07017
[Presentation] 神経発達期の多価不飽和脂肪酸欠乏による統合失調症前駆状態モデルの解析2017
- Author(s)
  前川素子, 浜崎景, 木村哲也, 渡辺明子, 岩山佳美, 大西哲生, 豊島学, 岩本和也, 高島明彦, 吉川武男
- Organizer
  日本脂質栄養学会第26回大会
- Data Source
  KAKENHI-PROJECT-15K09814
[Presentation] Laboratory for Molecular Psychiatry2017
- Author(s)
  Tetsuo Ohnishi
- Organizer
  University of Strasbourg-RIKEN Workshop on Membrane Lipidology
- Place of Presentation
  Strasbourg, France
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07017
[Presentation] 質量分析法を用いた統合失調症関連脂質の探索2017
- Author(s)
  島本知英, 大西哲生, 江崎加代子, 前川素子, 渡辺明子, 豊島学, 杉山栄二, 大和田祐二, 瀬藤光利, 吉川武男
- Organizer
  第12回日本統合失調症学
- Place of Presentation
  米子コンベンションセンターBIG SHIP（鳥取）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K09814
[Presentation] 統合失調症患者由来神経幹細胞における分化異常の分子病態2016
- Author(s)
  豊島学, 赤松和土, 岡田洋平, 大西哲生, 田中元雅, 岡野栄之, 吉川武男
- Organizer
  第46回日本神経精神薬理学会年会
- Place of Presentation
  COEX (韓国, ソウル)
- Invited
- Data Source
  KAKENHI-PLANNED-24116002
[Presentation] 毛根細胞を用いた精神疾患関連遺伝子の発現解析2016
- Author(s)
  前川素子, 大西哲生, 豊島学, 豊田倫子, 松﨑秀夫, 森則夫, 吉川武男
- Organizer
  第49回精神薬療報告会
- Place of Presentation
  千里ライフサイエンスセンター（大阪）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K09814
[Presentation] 22q11.2 欠失を伴った統合失調症患者由来神経幹細胞における分子病態解析2016
- Author(s)
  豊島学, 赤松和土, 岡田洋平, 大西哲生, Shabeesh Balan,　田中元雅, 岡野栄之, 吉川武男
- Organizer
  第11回日本統合失調症学会
- Place of Presentation
  ベイシア文化ホール（群馬）
- Year and Date
  2016-03-25
- Data Source
  KAKENHI-PLANNED-24116002
[Presentation] イメージング質量分析法を用いた統合失調症関連脂質の探索2016
- Author(s)
  島本知英, 大西哲生, 江崎加代子, 前川素子, 渡邉明子, 豊島学, 杉山栄二, 大和田祐二, 瀬藤光利, 吉川武男
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K09814
[Presentation] 染色体転座をともなう統合失調症症例の転座点に存在する転写調節因子の生物学的役割2015
- Author(s)
  大西哲生、渡辺明子、大羽尚子、岩山佳美、豊島学、島本知英、新井誠、山田一之、市川智恵、前川素子、野崎弥生、糸川昌成、吉川武男
- Organizer
  日本統合失調症学会
- Place of Presentation
  東京、都市センターホテル
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-24591737
[Presentation] Disturbed Gene Expression and Behavioral Defects Reminiscent of Scizophrenia in Mice Deficient in Disc-M, A Gene Encoding a Transcriptional Regulator2013
- Author(s)
  Ohnishi T, Watanabe A, Yamada K, Arima F, Kurokawa R, Iwayama Y, Arai M, Ohba H, Toyoshima M, Ichikawa T, Miyashita M, ManabeT, Hosoya T, Itokawa M, Yoshikawa T
- Organizer
  Society of Biological Psychiatry 2013 Annual Meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23390293
[Presentation] Multiple behavioral deficits reminiscent of schizophrenia in mice deficient in DISC-M (disrupted in schizophrenia matsuzawa), a gene encoding a transcriptional regulator2012
- Author(s)
  Ohnishi et al.
- Organizer
  2012 CINP Meeting
- Place of Presentation
  Stockholm, Sweden
- Data Source
  KAKENHI-PROJECT-24591737
[Presentation] Multiple behavioral deficits reminiscent of schizophrenia in mice deficient in DISC-M (disrupted in schizophrenia matsuzawa), a gene encoding a transcriptional regulator2012
- Author(s)
  Ohnishi T, Watanabe A, Yamada K, Ohba H, Arai M, Ichikawa C, Toyoshima M, Iwayama Y, Miyashita M, Itokawa M, Yoshikawa T
- Organizer
  28th CINP World Congress of Neuropsychoparmacology
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2012-06-05
- Data Source
  KAKENHI-PROJECT-23390293
[Presentation] 統合失調症関連遺伝子 DISM-M が制御する遺伝子ネットワークの同定2012
- Author(s)
  大西哲生, 渡邉明子, 大羽尚子, 豊島学, 山田一之, 新井誠, 市川智恵, 岩山佳美, 宮下光弘, 糸川昌成, 吉川武男
- Organizer
  第7回日本統合失調症学会
- Place of Presentation
  名古屋市, 愛知県
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-23390293
[Presentation] 統合失調症脆弱性形成におけるエピジェネティック修飾の関連性2011
- Author(s)
  前川素子, 渡邉明子, 大西哲生, 豊島学, 吉川武男
- Organizer
  第44回精神神経系薬物治療研究報告会
- Place of Presentation
  豊中市, 大阪府
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-23390293
[Presentation] Mice deficient in a gene encoding a transcriptional regulator exhibit multiple behavioral deficits reminiscent of schizophrenia2011
- Author(s)
  Ohnishi T, Watanabe A, M. Arai, Itokawa M, Yoshikawa T, et al
- Organizer
  66th Annual Meeting, Society for Biological Psychiatry
- Place of Presentation
  San Francisco, USA
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-21591535
[Presentation] Mice deficient in a gene encoding a transcriptional regulator exhibit multiple behavioral deficits reminiscent of schizophrenia2011
- Author(s)
  T Ohnishi, et al
- Organizer
  66th Annual Convention, Society of Biological Psychiatry
- Place of Presentation
  Hotel Hilton SF, San Francisco, USA
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-21591535
[Presentation] ゲノムワイド関連解析(GWAS)による統合失調症シグナルパスウェイの同定2011
- Author(s)
  山田和男, 岩山佳美, 服部栄治, 岩本和也, 豊田倫子, 大西哲生, 大羽尚子, 前川素子, 加藤忠史, 吉川武男
- Organizer
  日本生物学的精神医学会(第33回)
- Place of Presentation
  港区, 東京都
- Year and Date
  2011-05-22
- Data Source
  KAKENHI-PROJECT-23390293
[Presentation] Mice Deficient in a Gene Encoding a Transcriptional Regulator Exhibit Multiple Behavioral Deficits Reminiscent of Schizophrenia2011
- Author(s)
  Ohnishi T, Yamada K, Arai M, Watanabe A, Ohba H, Arima F, Ichikawa T, Ornthanalai G, Iwayama Yo, Maekawa M, Yamada K, Miyashita M, Murphy N P, Manabe T, Itokawa M, Yoshikawa T
- Organizer
  66th Annual Meeting of society of Biological Psychiatry
- Place of Presentation
  San Francisco, USA
- Year and Date
  2011-05-24
- Data Source
  KAKENHI-PROJECT-23390293
[Presentation] 精神疾患の生物学的研究2010
- Author(s)
  大西哲生
- Organizer
  東京都精神医学総合研究所セミナー
- Place of Presentation
  東京
- Year and Date
  2010-11-29
- Data Source
  KAKENHI-PROJECT-21591535
[Presentation] 統合失調症・自閉症で検出された脂肪酸結合タンパク質(FABP) 変異の解析
- Author(s)
  島本知英、大西哲生、前川素子、豊田倫子、岩山佳美、渡邉明子、大羽尚子、久野泰子、和田唯奈、田端千夏、座古保、大和田祐二、小林哲幸、吉川武男
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市(兵庫県)
- Data Source
  KAKENHI-PROJECT-23390293
[Presentation] 遺伝的イノシトール再利用経路抑制によるマウス頭部形成と脳発生の生物学的関連性の発見 ("A novel link between craniofacial morphogenesis and brain development identified by genetic disturbance in cellular inositol recycling")
- Author(s)
  大西哲生、村田卓也、渡辺明子、肥田昌子、大羽尚子、岩山佳美、赤木巧、三島和夫、権藤洋一、吉川武男
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市(兵庫県)
- Data Source
  KAKENHI-PROJECT-23390293
[Presentation] 染色体転座を伴うまれな統合失調症の原因遺伝子候補DISC-Mの機能
- Author(s)
  大西哲生、豊島学、前川素子、吉川武男
- Organizer
  第40回日本脳科学会
- Place of Presentation
  浜松市(静岡県)
- Data Source
  KAKENHI-PROJECT-23390293
[Presentation] 発達期の脂肪酸欠乏食投与による精神疾患関連遺伝子の発現変化 (Regulation of psychiatric disorder related genes by lack of PUFA during developmental stage in mice)
- Author(s)
  前川素子、木村哲也、浜崎景、渡辺明子、岩山佳美、大羽尚子、久野泰子、文東美紀、岩本和也、大西哲生、豊島学、大隅典子、加藤忠史、高島明彦、吉川武男
- Organizer
  Neuro2013 (日本神経科学学会、日本神経化学会、日本神経回路学会)
- Place of Presentation
  京都市(京都府)
- Data Source
  KAKENHI-PROJECT-23390293

1. YOSHIKAWA Takeo (30249958)

# of Collaborated Projects: 17 results

# of Collaborated Products: 69 results
2. YAMADA Kazuo (10322695)

# of Collaborated Projects: 8 results

# of Collaborated Products: 24 results
3. MAEKAWA Motoko (50435731)

# of Collaborated Projects: 6 results

# of Collaborated Products: 29 results
4. TOYOSHIMA Manabu (90582750)

# of Collaborated Projects: 6 results

# of Collaborated Products: 34 results
5. ARAI Makoto (80356253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. ITOKAWA Masanari (40332324)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
7. SHIMAMOTO Chie (90755117)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
8. 豊田倫子 (20392045)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. HATTORI Eiji (80399443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. OKAZAKI Yuji (40010318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIYATA Toshio (10222332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. KOBAYASHI Toshihide (60162004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. IWAYAMA Yoshimi (60399441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 渡辺明子 (40210992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 木村英雄 (30321889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 江崎加代子 (20744874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
17. 岩本和也 (40342753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. 中谷明弘 (60301149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 高田篤 (90643693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TSUJII Masatugu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. TAKAGAI Shu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. KIKUCHI Mituru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. KIMURA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. MURATA Yui

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. KITA Yoshikuni

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. HAYASHI Yasunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. HINO Okio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. TORIUMI Kazuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. KIYAMA Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 鈴木勝昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 大和田祐二

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
32. 橋本謙二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 山下典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 木村龍一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 文東美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 高島明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 岡田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
38. 岡野栄之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
39. 松崎秀夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
40. 岡崎祐士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 権藤洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 村田卓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 加藤忠史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 宮冬樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 西昭徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 大西克典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 矢部博興

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
48. 矢野真人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 橋本恵理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 林朗子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 松本純弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 渡辺能行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 渡辺俊樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 奥野浩行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 神庭重信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 岩田仲生

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
57. 尾崎紀夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

OHNISHI TETSUO 大西 哲生

大西 哲生 オオニシ テツオ

OHNISHI Tetsuo 大西 哲生

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新規遺伝子発現調節メカニズムLDB2-EGR/ARC系と精神疾患Principal Investigator

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Involvement of the transcription complex in higher brain functionPrincipal Investigator

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Gene networks governed by DISC-M and schizophreniaPrincipal Investigator

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Analysis of Dicc-M KO mice to reveal the pathogenesis of schizophreniaPrincipal Investigator

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OHNISHI TETSUO 大西哲生

大西哲生オオニシテツオ

OHNISHI Tetsuo 大西哲生