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YOKOZEKI Takeaki  横関 健昭

ORCIDConnect your ORCID iD *help
Researcher Number 80373405
Other IDs
Affiliation (based on the past Project Information) *help 2009: 筑波大学, 大学院・人間総合科学研究科, 講師
2007: 筑波大, 人間総合科学研究科, 講師
2006: 筑波大学, 大学院人間総合科学研究科, 講師
2005: UNIVERSITY OF TSUKUBA, GRADUATE SCHOOL OF COMPREHENSIVE HUMAN SCIENCES, ASSOCIATE PROFESSOR, 大学院・人間総合科学研究科, 講師
Review Section/Research Field
Principal Investigator
Functional biochemistry / Biological Sciences
Except Principal Investigator
Biological Sciences / Functional biochemistry / Cell biology / Biological pharmacy
Keywords
Principal Investigator
リン脂質 / 細胞膜形態変化 / 細胞内シグナル伝達 / ノックアウトマウス / エンドサイトーシス / シナプス小胞
Except Principal Investigator
シグナル伝達 / 脂質性シグナル分子産生酵素 / PIP5K / ARF6 … More / PIP5Kβ / PIP5Kγ661 / ノックアウトマウス / スパイン / 低分子量G蛋白質 / ホスホリパーゼD / エンドサイトーシス / シナプス小胞 / AP-2複合体 / シナプス / 海馬神経細胞 / 好中級 / セリン残基 / ホスファチジル化 / 翻訳後修飾 / ホスファチジル基転移反応 / Bio-lipid / AP-2 complex / endocytosis / knockout mice / synaptic vesicle / lipid kinase / single transduction / 神経 / アレルギー / シナプト小胞 / 脂質キナーゼ / Signal transduction / Endocytosis / Synaptic vesicle / AP-2 adaptor complex / Spine / Signaling lipid-producing enzyme / アナフィラキシー / 高次脳機能 / ヒスタミン放出反応 / 肥満細胞 / 脂質シグナル分子 / 脂質性シグナル分子産生酵 / 血管内皮細胞 / 肝臓発生 / 管形成 / 形態形成 / ターゲット蛋白質 / JLP / 脳神経発生 / 抗ガン剤 / 癌 / 血管形成 / 神経突起 / 肝臓 / 腫瘍血管形成 / 神経細胞 / リン脂質キナーゼ / Arf6 / PLD / 蛋白質 / 脂質 / 飜訳後修飾 / セリン Less
  • Research Projects

    (8 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (7 People)
  •  ホスホイノシチドキナーゼによるシナプス小胞リサイクリング制御機構の解析Principal Investigator

    • Principal Investigator
      横関 健昭
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  ホスホリパーゼDシグナルの時空的発信調節機構とその生理機能の解析Principal Investigator

    • Principal Investigator
      横関 健昭
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      University of Tsukuba
  •  ANALYSIS OF PHYSIOLOGICAL FUNCTION OF LIPID SIGNALLING SYSTEM

    • Principal Investigator
      KANAHO Yasunori
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      University of Tsukuba
  •  リン脂質シグナル伝達による神経細胞動態制御機構の解析

    • Principal Investigator
      金保 安則
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  Bio・lipid産生酵素による新規な蛋白質翻訳後修飾と蛋白質運命の解析Principal Investigator

    • Principal Investigator
      横関 健昭, 金保 安則
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  Molecular mechanisms of phospholipid metabolism and cell morphology regulated by small G protein signaling

    • Principal Investigator
      KANAHO Yasunori
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  ホスホリパーゼDによるタンパク質翻訳後修飾ホスファチジル化の解析

    • Principal Investigator
      KANAHO Yasunori
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      University of Tsukuba
      Tokyo Metropolitan Organization for Medical Research
  •  STUDIES ON FUNCTION AND SHIGNALING MECHANISM OF LIPID SIGNALING MOLECULE-PRODUCING ENZYME FOR ESTABLISHMENT OF HIGHLY ORGANIZED BRAIN FUNCTION

    • Principal Investigator
      KANAHO Yasunori
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cell biology
    • Research Institution
      UNIVERSITY OF TSUKUBA
      Tokyo Metropolitan Organization for Medical Research

All 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] Novel activation mechanism and physiological function of PIP5Kγ6612007

    • Author(s)
      Y. Kanaho, A. Nakano-Kobayashi, and T. Yokozeki
    • Journal Title

      Adv. Enzyme Regul (in press)(no peer review)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Journal Article] Role of activation of PIP5K y661 by AP-2 complex in synaptic vesicle endocytosis2007

    • Author(s)
      Nakano-Kobayashi A, Yamazaki M, Unoki T, Hongu T, Murata C, Taguchi R, Katada T, Frohman M. A, Yokozeki T. and Kanaho Y
    • Journal Title

      EMBO J 26(peer review)

      Pages: 1105-1116

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Journal Article] The phosphoinositide kinase PIP5K that produces the versatile signaling phospholipid PI4, 5P_<2>2007

    • Author(s)
      Y. Kanaho, A. Nakano-Kobayashi, and T. Yokozeki
    • Journal Title

      Biol. Pharm. Bull 30

      Pages: 1605-1609

    • NAID

      110006380236

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Journal Article] Regulation of phosphatidylinositol 4-phosphate 5-kinase activity by partner proteins2007

    • Author(s)
      Y. Kanaho, K. Nakayama, M. A. Frohman, and T. Yokozeki
    • Journal Title

      Methods Enzymol 434(no peer review)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Journal Article] Role of activation of PIP5K・661 by AP-2 complex in synaptic vesicle endocytosis.2007

    • Author(s)
      Nakano-Kobayashi A., Yamazaki M., Unoki T., Hongu T., Murata C., Taguchi R., Katada T., Frohman M.A., Yokozeki T., Kanaho Y.
    • Journal Title

      EMBO J. 26

      Pages: 1105-1116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17079008
  • [Journal Article] Crucial role of the small GTPase ARF6 in hepatic cord formation during liver developent2006

    • Author(s)
      Suzu T, Kanai Y, Hara T, Sasaki T, Khara M, Maehama T, Taya C, Shitara H, Yonekawa H, Frohaman M. A., Yokozeki T. and Kanaho Y
    • Journal Title

      Mol. Cell. Biol 26(peer review)

      Pages: 6149-6156

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Journal Article] Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development.2006

    • Author(s)
      Suzuki T., Kanai Y., Hara T., Sasaki J., Sasaki T., Kohara M., Maehama T., Taya C., Shitara H., Yonekawa H., Frohaman M.A., Yokozeki T., Kanaho Y.
    • Journal Title

      Mol. Cell. Biol. 26

      Pages: 6149-6156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17079008
  • [Journal Article] The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation2005

    • Author(s)
      H.Miyazaki, M.Yamazaki, H.Watanabe, T.Maehama, T.Yokozeki, Y.Kanaho
    • Journal Title

      FEBS Lett. 579

      Pages: 6834-6837

    • Data Source
      KAKENHI-PROJECT-17024066
  • [Journal Article] The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation2005

    • Author(s)
      H.Miyazaki, M.Yamazaki, H.Watanabe, T.Maehama, T.Yokozeki, Y.Kanaho
    • Journal Title

      FEBS Lett. 579

      Pages: 6834-6837

    • Data Source
      KAKENHI-PROJECT-16370091
  • [Journal Article] The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation2005

    • Author(s)
      H.Miyazaki, M.Yamazaki, H.Watanabe, T.Maehama, T.Yokozeki, Y.Kanaho
    • Journal Title

      FEBS Lett. 579

      Pages: 6834-6837

    • Data Source
      KAKENHI-PROJECT-17028058
  • [Journal Article] The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.2005

    • Author(s)
      Miyazaki H., Yamazaki M., Watanabe H., Maehama T., Yokozeki T., Kanaho Y.
    • Journal Title

      FEBS Lett. 579

      Pages: 6834-6837

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17079008
  • [Journal Article] The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.2005

    • Author(s)
      H.Miyazaki, M.Yamazaki, H.Watanabe, T.Maehama, T.Yokozeki, Y.Kanaho
    • Journal Title

      FEBS Lett. 579

      Pages: 6834-6837

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370091
  • [Journal Article] The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation2005

    • Author(s)
      H.Miyazaki, M.Yamazaki, H.Watanabe, T.Maehama, T.Yokozeki, Y.Kanaho
    • Journal Title

      FEBS Lett. 579

      Pages: 6834-6837

    • Data Source
      KAKENHI-PROJECT-17079008
  • [Journal Article] The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation2005

    • Author(s)
      H.Miyazaki, M.Yamazaki, H.Watanabe, T.Maehama, T.Yokozeki, Y.Kanaho
    • Journal Title

      FEBS Lett. 579

      Pages: 6834-6837

    • Data Source
      KAKENHI-PROJECT-16659026
  • [Presentation] The scaffold protein JLP as a novel partner protein of the small GTPase ARF6.2007

    • Author(s)
      C. Arikawa, T. Yokozeki, and Y. Kanaho
    • Organizer
      2007 International Symposium on "G-protein Signaling"
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-07-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Activation mechanism and physiological function of the PIP2 producing enzyme PIP5K2007

    • Author(s)
      Y. Kanaho, A. Nakano-Kobayashi, and T. Yokozeki
    • Organizer
      The 49th Japanese Conference of Lipid Biochemistry
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2007-06-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Functional analysis of PIP5Kγ and KIF2A on regulation of neurite extension2007

    • Author(s)
      Y. Kanaho, S. Anze, T. Yokozeki, and A. Nakano-Kobayashi
    • Organizer
      Biochemistry and Molecular Biology 2007
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Roe of small GTPase ARF6 in embryonic angiogenesis2007

    • Author(s)
      T. Hongu, T. Suzuki, T. Yokozeki, Y. Kanaho
    • Organizer
      2007 International Symposium on "G-protein Signaling"
    • Place of Presentation
      東京
    • Year and Date
      2007-07-28
    • Data Source
      KAKENHI-PROJECT-17079008
  • [Presentation] Role of small GTPase in Embryonic angiogenesis.2007

    • Author(s)
      T. Hongu, T. Suzuki, T. Yokozeki, Y. Kanaho
    • Organizer
      The 5th Korea-Japan Conference on Cellular Signaling for Young Scientists
    • Place of Presentation
      Gyeongju, Republic of Korea
    • Year and Date
      2007-07-09
    • Data Source
      KAKENHI-PROJECT-17079008
  • [Presentation] Roe of small GTPase ARF6 in embryonic angiogenesis2007

    • Author(s)
      T. Hongu, T. Suzuki, T. Yokozeki, and Y. Kanaho
    • Organizer
      2007 International Symposium on "G-protein Signaling"
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-07-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Function of the small G protein ARF6 in angiogenesis2007

    • Author(s)
      T. Hongu, T. Suzuki, T. Yokozeki, and Y. Kanaho
    • Organizer
      The 6th Life Science Conference
    • Place of Presentation
      Chiba, Japan
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] PLD2 activation is required for PDGF-induced membrane ruffle formation in NIH-3T3 cells2007

    • Author(s)
      T. Yokozeki, A. Hara, H. Watanabe, and Y. Kanaho
    • Organizer
      The 20th IUBMB Congress and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2007-06-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Activation of phosphatidylinositol 4-phosphate 5-kinase gamma661 is essential for synaptic vesicle endocytosis2007

    • Author(s)
      A. Nakano-Kobayashi, T. Yokozeki, and Y. Kanaho
    • Organizer
      The FASEB Summer Research Conference(Phospholipases)
    • Place of Presentation
      Vermont, USA
    • Year and Date
      2007-07-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Hunting of novel binding protein of the small G protein ARF62007

    • Author(s)
      C. Arikawa, T. Yokozeki, and Y. Kanaho
    • Organizer
      Biochemistry and Molecular Biology 2007
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Novel interaction of phosphatidylinositol 4-phosphate 5-kinasey661 with AP-2 adaptor complex regulates synaptic vesicle endocytosis2007

    • Author(s)
      A. Nakano-Kobayashi, T. Yokozeki, and Y. Kanaho
    • Organizer
      the 20th IUBMB Congress and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2007-06-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Role of small GTPase in Embryonic angiogenesis2007

    • Author(s)
      T. Hongu, T. Suzuki, T. Yokozeki, and Y. Kanaho
    • Organizer
      The 5th Korea-Japan Conference on Cellular Signaling for Young Scientists
    • Place of Presentation
      Gyeongju. Republic of Korea
    • Year and Date
      2007-07-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Generation and analysis of PIP5K knockout mice2007

    • Author(s)
      T. Unoki, T. Yokozeki, and Y. Kanaho
    • Organizer
      The 5th Korea-Japan Conference on Cellular Signaling for Young Scientists
    • Place of Presentation
      Gyeongju Republic of Korea
    • Year and Date
      2007-07-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Function of the small G protein ARF6 in angiogenesis2007

    • Author(s)
      T. Hongu, T. Suzuki, T. Yokozeki, and Y. Kanaho
    • Organizer
      Biochemistry and Molecular Biology 2007
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] The scaffold protein JLP as a novel -6 - partner protein of the small GTPase ARF6.2007

    • Author(s)
      C. Arikawa, T. Yokozeki, Y. Kanaho
    • Organizer
      2007 International Symposium on "G-protein Signaling"
    • Place of Presentation
      東京
    • Year and Date
      2007-07-28
    • Data Source
      KAKENHI-PROJECT-17079008
  • [Presentation] Physiological function of the small G protein ARF6 in hepatic cord formation and liver development.2006

    • Author(s)
      T. Suzuki, Y. Kanai, T. Hara, J. Sasaki, T. Sasaki, M. Kohara, T. Maehama, T. Yokozeki, Y. Kanaho
    • Organizer
      The 20th IUBMB Congress and 11th FAOBMB Congress
    • Place of Presentation
      京都
    • Year and Date
      2006-06-21
    • Data Source
      KAKENHI-PROJECT-17079008
  • [Presentation] Regulatory mechanism of synaptic endocytosis by PIP5Kγ2006

    • Author(s)
      A. Kobayashi-Nakano, T. Yokozeki, and Y. Kanaho
    • Organizer
      The 48th Japanese Conference on the Biochemistry of Lipids
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-06-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Physiological function of the small G protein ARF6 in hepatic cord formation and liver development2006

    • Author(s)
      Suzuki, Y. Kanai, T. Hara, J. Sasaki, T. Sasaki, M. Kohara, T. Maehama, T. Yokozeki, and Y. Kanaho
    • Organizer
      The 20th IUBMB Congress and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2006-06-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Role of phospholipase D in membrane ruffle formation2006

    • Author(s)
      T. Yokozeki, A. Hara, and Y. Kanaho
    • Organizer
      The 48th Japanese Conference on the Biochemistry of Lipids
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-06-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Role of phospholipase D in membrane ruffle formation2006

    • Author(s)
      T. Yokozeki, A. Hara, and Y. Kanaho
    • Organizer
      The 5th Life Science Meeting
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2006-07-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] Activation of phosphatidylinositol 4-phosphate 5-kinase gamma661 is essential for synaptic vesicle endocytosis2006

    • Author(s)
      A. Kobayashi-Nakano, T. Yokozeki, and Y. Kanaho
    • Organizer
      The 5th Life Science Meeting
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2006-07-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18370053
  • [Presentation] ARF6 is required for hepatic cord formation and liver development.2005

    • Author(s)
      T. Suzuki, Y. Kanai, T. Hara, J. Sasaki, T. Sasaki, M. Kohara, T. Yokozeki, T. Maehama, Y. Kanaho
    • Organizer
      第78回日本生化学会大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-17079008
  • 1.  KANAHO Yasunori (00214437)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 36 results
  • 2.  FUNAKOSHI Yuji (30415286)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  HASEGAWA Hiroshi (88928814)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  SUGIMOTO Rika (40455936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  MAEHAMA Tomohiko (40322755)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  田口 良 (20080210)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  前濱 朝彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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