MITSUMORI Toru 三森徹

Researcher Number	80377514
Affiliation (Current)	2025: 順天堂大学, 医学部, 先任准教授
Affiliation (based on the past Project Information) *help	2017 – 2020: 山梨大学, 大学院総合研究部, 講師 2014 – 2016: 山梨大学, 総合研究部, 助教 2012 – 2013: 山梨大学, 医学部附属病院, 助教 2008: 山梨大学, 医学部・附属病院, 助教 2008: 山梨大学, 医学部附属病院, 助教 2007: 山梨大学, 医学部附属病院, シニアレジデント 2006: 山梨大学, 医学部附属病院, 医員
Review Section/Research Field	Except Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related
Keywords	Except Principal Investigator JAK2V617F / Lysyl oxidase / ERストレス / lysyl oxidase / metformin / 骨髄増殖性腫瘍 / 白血病 / メトホルミン / 分子シャペロン / UPR … More / TIMP / MMP / SAPK/JNK / type1 コラーゲン / 骨髄間質細胞 / GRP78 / MMP9 / ATF4 / 骨髄線維症 / 小胞体ストレス / MCT / 乳酸 / 骨髄線維化 / 低酸素 / 活性酸素 / 糖代謝 / 線維化 / PP2A / myelofibrosis / TETファミリー / エピゲノム / JAK２変異 / 低酸素応答 / methylation / WNT5 / Hypoxia / Wnt5 / TET2 / hypoxia / IGF-1 / survivin / 多発性骨髄腫 / HIF-1 / FTY720 / protein phosphatase 2A / 分子標的治療 / オールトランスレチノイン酸 / FOXO3A / 急性前骨髄球性白血病 / アポトーシス / 寿命関連遺伝子 / 薬剤耐性 / 抗癌薬 / 血液内科学 Less

Enhanced ER stress response in MPN cells involved in development of myelofibrosis through secretion of GRP78
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
Role of glucose metabolism in development of myelofibrosis
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Hypoxia modulate epigenomic response in MPN cells
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Development of novel therapeutic strategy for targeting transcription factors expressed in cancer stem cells
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi

All 2019 2017 2015 2014 2008 2007

All Journal Article Presentation

[Journal Article] Glycolytic enzyme hexokinase II is a putative therapeutic target in B-cell malignant lymphoma2019
- Author(s)
  Nakajima Kei、Kawashima Ichiro、Koshiisi Megumi、Kumagai Takuma、Suzuki Megumi、Suzuki Jun、Mitsumori Toru、Kirito Keita
- Journal Title
  
  Experimental Hematology
  
  Volume: 78 Pages: 46-55.e3
- DOI
  10.1016/j.exphem.2019.09.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08319, KAKENHI-PROJECT-19K17826
[Journal Article] Clinical Efficacy and Safety of First-Line Dasatinib Therapy and the Relevance of Velocity of BCR-ABL1 Transcript Decline for Achievement of Molecular Responses in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: Report from the Juntendo Yamanashi Cooperative Study Group2017
- Author(s)
  Takaku Tomoiku、Iriyama Noriyoshi、Mitsumori Toru、Sato Eriko、Gotoh Akihiko、Kirito Keita、Noguchi Masaaki、Koike Michiaki、Sakamoto Junichi、Oba Koji、Komatsu Norio
- Journal Title
  
  Oncology
  
  Volume: 94 Issue: 2 Pages: 85-91
- DOI
  10.1159/000481945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09470
[Journal Article] Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells2015
- Author(s)
  Kawashima, I. Mitsumori, T. Nozaki, Y. Yamamoto, T. Shobu-Sueki, Y. Nakajima, K. Kirito, K.
- Journal Title
  
  Exp Hematol
  
  Volume: in press Issue: 7 Pages: 524-533.e1
- DOI
  10.1016/j.exphem.2015.03.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591386, KAKENHI-PROJECT-15K09470
[Journal Article] Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells2014
- Author(s)
  Mitsumori, T. Nozaki, Y. Kawashima, I. Yamamoto, T. Shobu, Y. Nakajima, K. Morishita, S. Komatsu, N. Kirito, K.
- Journal Title
  
  Exp Hematol
  
  Volume: 42 Issue: 9 Pages: 783-792.e1
- DOI
  10.1016/j.exphem.2014.05.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591386
[Journal Article] Pure erythroid leukemia(M6b).2008
- Author(s)
  Mitsumori T
- Journal Title
  
  Rinsho Ketsueki 49
  
  Pages: 1-2
- NAID
  10021256744
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Pure erythroid leukemia (M6b)2008
- Author(s)
  Mitsumori T
- Journal Title
  
  Rinsho Ketsueki 49
  
  Pages: 1-2
- NAID
  10021256744
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Multiple myeloma with grape cell-like changes in almost all myeloma cells.2007
- Author(s)
  Mitsumori T
- Journal Title
  
  Rinsho Ketsueki 48
  
  Pages: 1453-1453
- Data Source
  KAKENHI-PROJECT-18390282
[Presentation] 日本における二次性骨髄線維症の予後予測モデルの比較検討2019
- Author(s)
  鈴木愛、鈴木潤、輿石めぐみ、川島一郎、中嶌圭、三森徹、桐戸敬太
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08319
[Presentation] Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-12017
- Author(s)
  Nakajima, Kei Kirito, Keita Kawashima, Ichiro Koshiishi, Megumi Kumagai, Takuma Mitsumori, Toru
- Organizer
  第５９回米国血液学会
- Data Source
  KAKENHI-PROJECT-15K09470

1. KIRITO Keita (90306150)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. NOZAKI Yumi (80530104)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 川島一郎 (20622369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. KOMATSU Norio (50186798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KUNITAMA Masae (60397297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAGASHIMA Takahiro (10343443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAKOE Kumi (10398505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAJIMA Kei (20447709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

MITSUMORI Toru 三森 徹

Research Projects

Research Products

Co-Researchers

Enhanced ER stress response in MPN cells involved in development of myelofibrosis through secretion of GRP78

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of glucose metabolism in development of myelofibrosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hypoxia modulate epigenomic response in MPN cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic strategy for targeting transcription factors expressed in cancer stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Glycolytic enzyme hexokinase II is a putative therapeutic target in B-cell malignant lymphoma2019

Author(s)

Journal Title

DOI

Data Source

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pure erythroid leukemia(M6b).2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Pure erythroid leukemia (M6b)2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Multiple myeloma with grape cell-like changes in almost all myeloma cells.2007

Author(s)

Journal Title

Data Source

[Presentation] 日本における二次性骨髄線維症の予後予測モデルの比較検討2019

Author(s)

Organizer

Data Source

[Presentation] Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-12017

Author(s)

Organizer

Data Source

MITSUMORI Toru 三森徹