Iwasa Motoo 岩佐元雄

… Alternative Names

岩佐元雄イワサモトオ

IWASA Motoo 岩佐元雄

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Researcher Number	80378299
Other IDs
Affiliation (Current)	2025: 三重大学, 医学系研究科, リサーチアソシエイト
Affiliation (based on the past Project Information) *help	2025: 三重大学, 医学部附属病院, 准教授 2022 – 2023: 三重大学, 医学部附属病院, 准教授 2014 – 2015: 三重大学, 医学(系)研究科(研究院), 准教授 2012 – 2013: 三重大学, 医学部附属病院, 准教授
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 胆汁酸 / 慢性肝疾患 / 分岐差アミノ酸 / 肝硬変 / 分岐鎖アミノ酸 / リトコール酸 / サルコペニア / 凝固線溶系 / 肝線維化 / TAFI / NKT細胞 / プロテインS / アルコール性肝障害 … More Except Principal Investigator … More protein S / 組織リモデリング / 凝固・線溶系 / 動脈硬化症 / 脂肪性肝炎 Less

抱合胆汁酸に焦点を当てた肝筋連関の解明と肝関連サルコペニアの診断・治療Principal Investigator
- Principal Investigator
  
  岩佐元雄
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Mie University
胆汁酸を起点とした肝筋連関の解明と肝性サルコペニアの診断・治療Principal Investigator
- Principal Investigator
  
  岩佐元雄
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Mie University
Elucidation of the common mechanisms of tissue remodeling in nonalcoholic steatohapatitis
- Principal Investigator
  
  Takei Yoshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Mie University
Approaches to the pathogenesis and treatment of liver fibrosis through genetically modified mice.Principal Investigator
- Principal Investigator
  
  IWASA Motoo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Mie University

All 2023 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Pathophysiology and management of hepatic encephalopathy 2014 update: Ammonia toxicity and hyponatremia.2015
- Author(s)
  Iwasa M, Takei Y
- Journal Title
  
  Hepatol Res
  
  Volume: 45 Issue: 12 Pages: 1155-1162
- DOI
  10.1111/hepr.12495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460990
[Journal Article] Elevation of branched-chain amino acid levels in diabetes and NAFL and changes with antidiabetic drug treatment2015
- Author(s)
  Iwasa M, Ishihara T, Mifuji-Moroka R, Fujita N, Kobayashi Y, Hasegawa H, Iwata K, Kaito M, Takei Y
- Journal Title
  
  Obes Res Clin Pract
  
  Volume: 9 Issue: 3 Pages: 293-297
- DOI
  10.1016/j.orcp.2015.01.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460990
[Journal Article] Usefulness of Levocarnitine and/or Branched-Chain Amino Acids during Invasive Treatment for Hepatocellular Carcinoma.2015
- Author(s)
  Iwasa M, Sugimoto R, Ishihara T, Sekoguchi-Fujikawa N, Yoshikawa K, Mifuji-Moroka R, Tanaka H, Kobayashi Y, Hasegawa H, Takei Y.
- Journal Title
  
  J Nutr Sci Vitaminol (Tokyo)
  
  Volume: 61 Issue: 10 Pages: 433-440
- DOI
  10.1111/hepr.12471
- NAID
  130005125479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460990
[Journal Article] Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells.2015
- Author(s)
  Chelakkot-Govindalayathil AL, Mifuji-Moroka R, D'Alessandro-Gabazza CN, Toda M, Matsuda Y, Gil-Bernabe P, Roeen Z, Yasuma T, Yano Y, Gabazza EC, Iwasa M, Takei Y.
- Journal Title
  
  J Thromb Haemost.
  
  Volume: １３（１） Issue: 1 Pages: 142-154
- DOI
  10.1111/jth.12789
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590967, KAKENHI-PROJECT-24591128, KAKENHI-PROJECT-15K09170, KAKENHI-PROJECT-25460990
[Journal Article] Change in skeletal muscle mass after administering entecavir in patients with hepatitis B.2015
- Author(s)
  Iwasa M, Sugimoto R, Yoshikawa K, Miyachi H, Mifuji-Moroka R, Tanaka H,Kobayashi Y, Hasegawa H, Takei Y.
- Journal Title
  
  Nutrition.
  
  Volume: 31 Issue: 9 Pages: 1173-1174
- DOI
  10.1016/j.nut.2015.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460990
[Journal Article] Evaluation and prognosis of sarcopenia using impedance analysis in patients with liver cirrhosis.2014
- Author(s)
  Iwasa M, Hara N, Terasaka E, Hattori A, Ishidome M, Mifuji-Moroka R, Miyachi H, Sugimoto R, Tanaka H, Fujita N, Kobayashi Y, Iwata K, Takei Y.
- Journal Title
  
  Hepatol Res
  
  Volume: 44 Issue: 10
- DOI
  10.1111/hepr.12217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460990
[Journal Article] Nutrition therapy using a multidisciplinary team improves survival rates in patients with liver cirrhosis.2013
- Author(s)
  Iwasa M, Iwata K, Hara N, Hattori A, Ishidome M, Sekoguchi-Fujikawa N, Mifuji-Moroka R, Sugimoto R, Fujita N, Kobayashi Y, Takei Y
- Journal Title
  
  Nutrition
  
  Volume: 29 Issue: 11-12 Pages: 1418-1421
- DOI
  10.1016/j.nut.2013.05.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460990
[Journal Article] Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis.2013
- Author(s)
  Iwasa M, Kobayashi Y, Mifuji-Moroka R, Hara N, Miyachi H, Sugimoto R, Tanaka H, Fujita N, Gabazza EC, Takei Y
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 7 Pages: e70309-e70309
- DOI
  10.1371/journal.pone.0070309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] 主題：肝硬変合併症の基礎と臨床　リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変患者の予後を規定する2023
- Author(s)
  江口暁子　岩佐元雄　中川勇人
- Organizer
  日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-22K08011
[Presentation] リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変患者の予後を規定する2023
- Author(s)
  江口暁子　岩佐元雄　中川勇人
- Organizer
  日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-22K08011
[Presentation] 主題：肝疾患の病態に基づいた治療戦略　慢性肝疾患に伴う骨格筋障害における肝細胞由来臓器間病態伝達体の役割2023
- Author(s)
  江口暁子　岩佐元雄　中川勇人
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08011
[Presentation] リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変ラットやヒトの骨格筋量増加に寄与する2023
- Author(s)
  江口暁子　岩佐元雄　中川勇人
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08011
[Presentation] 肝疾患における内臓肥満とサルコペニアの病態への関与2015
- Author(s)
  岩佐元雄、原なぎさ、竹井謙之
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台国際センター　（仙台市）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] Effect of Branched Chain Amino Acids on Iron Transport in the Liver and Small Intestine of a Cirrhotic Rat Model2015
- Author(s)
  Yoshinao Kobayashi, RyosukeSugimoto, Motoh Iwasa, Yoshiyuki Takei
- Organizer
  AASLD LIVER MEETING
- Place of Presentation
  米国　サンフランシスコ
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] ALDとNASHの治療学１：栄養療法2015
- Author(s)
  岩佐元雄、竹井謙之
- Organizer
  第50回日本アルコール・薬物医学会　第27回日本依存神経精神科学会
- Place of Presentation
  神戸国際会議場　（神戸市）
- Year and Date
  2015-10-11
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] アルコール性肝障害におけるProtein Sの肝NKT細胞活性化を介した病態への関与.2015
- Author(s)
  諸岡留美、岩佐元雄、長谷川浩司、竹井謙之、ガバザエステバン
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本　（熊本市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] アルコール性肝障害患者における各種adipocytokineの動態解析2015
- Author(s)
  藤田尚己、宮地洋英、杉本龍亮、諸岡留美、田中秀明、岩佐元雄、長谷川浩司、竹井謙之
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本　（熊本市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] Voxel-Based Morphometryを用いたアルコール性肝障害患者の脳画像解析2015
- Author(s)
  諸岡留美、岩佐元雄、吉川恭子、杉本龍亮、宮地洋英、長谷川浩司、小林由直、竹井謙之、石田聡
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本　（熊本市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] Sarcopenic obesity impairs prognosis of patients with cirrhosis2015
- Author(s)
  Motoh Iwasa, Ryosuke Sugimoto, Yoshinao Kobayashi, Yoshiyuki Takei
- Organizer
  AASLD LIVER MEETING
- Place of Presentation
  米国　サンフランシスコ
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] サルコペニアおよびサルコペニア肥満を合併した肝硬変の生命予後とその対策2015
- Author(s)
  原なぎさ、岩佐元雄、宮地洋英、杉本龍亮、諸岡留美、田中秀明、長谷川浩司、岩田加壽子、竹井謙之
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本　（熊本市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] 生活習慣がもたらす肝疾患：アルコール性肝障害とNAFLD2015
- Author(s)
  竹井謙之、長谷川浩司、岩佐元雄
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本　（熊本市）
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] Protein SはNKT細胞の活性化を介して急性アルコール性肝障害を増悪させる2014
- Author(s)
  諸岡留美、岩佐元雄、ガバザエステバン、竹井謙之
- Organizer
  第50回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590967
[Presentation] 急性アルコール性肝障害における自然免疫、特にNKTの関与―Protein Sを用いた検討2013
- Author(s)
  諸岡留美, 杉本龍亮, 宮地洋英, 田中秀明, 藤田尚己, 小林由直, 岩佐元雄, ガバザ・エステバン , 竹井謙之
- Organizer
  肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590967
[Presentation] Effect of branched-chain amino acids on iron and glucose metabolism in rats with liver cirrhosis2013
- Author(s)
  Kobayashi Y, Iwasa M, Miyachi H, Takei Y
- Organizer
  AASLD (THE LIVER EETING 2013)
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] Protein S exacerbates acute alcohol-induced liver injury by enhancing activation of liver natural killer T cells2013
- Author(s)
  Hirohide Miyachi, Rumi Moroka, Naoki Fujita, Yoshinao Kobayashi, Motoh Iwasa, Esteban C Gabazza* and Yoshiyuki Takei
- Organizer
  第64回米国肝臓学会
- Place of Presentation
  ワシントン
- Data Source
  KAKENHI-PROJECT-24590967
[Presentation] Protein S exacerbates acute alcohol-induced liver injury by enhancing acyivation of liver ntural killerT cells2013
- Author(s)
  Iwasa M, Takei Y, Fujita N, Moroka R, Tanaka H, Sugimoto R, Kobayashi Y, Gabazza E
- Organizer
  17th International Stmposium on Cells of the Hepatic Sinusoid
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] Hepatic iron-mediated oxidative stress affects insulin resistance through the forkhead box-containing protein O subfamily-1 (foxo-1) pathway in chronic hepatitis C2013
- Author(s)
  Kobayashi Y, Iwasa M, Miyachi H, Takei Y
- Organizer
  AASLD (THE LIVER EETING 2013)
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] Protein S exacerbates activation of liver natural killer T (NKT) cells during alcohol-induced liver injury2013
- Author(s)
  Miyachi H, Moroka R, Fujita N, Kobayashi Y, Iwasa M, Takei Y
- Organizer
  AASLD (THE LIVER EETING 2013)
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] アルコール性肝障害におけるProtein Sの肝NKT細胞活性化を介した病態への関与
- Author(s)
  諸岡留美, 岩佐元雄, 長谷川浩司, ガバザ・エステバン , 竹井謙之
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本
- Year and Date
  2015-05-21 – 2015-05-22
- Data Source
  KAKENHI-PROJECT-24590967
[Presentation] Protein SはNKT細胞の活性化を介して急性アルコール性肝障害を増悪させる
- Author(s)
  諸岡留美，岩佐元雄，杉本龍亮，宮地洋英，田中秀明，藤田尚己，小林由直，ガバザエステバン，竹井謙之
- Organizer
  第５０回日本肝臓学会総会
- Place of Presentation
  東京　ホテルニューオータニ
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] 各種肝疾患における鉄過剰の臨床的意義とその成因の検討
- Author(s)
  藤田尚己，岩佐元雄，竹井謙之
- Organizer
  第５０回日本肝臓学会総会ワークショップ
- Place of Presentation
  東京　ホテルニューオータニ
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] Protein SはNKT細胞の活性化を介して急性アルコール性肝障害を増悪させる
- Author(s)
  竹井謙之、諸岡留美、岩佐元雄
- Organizer
  第２８回肝類洞経壁細胞研究会学術集会
- Place of Presentation
  岡山　アークホテル岡山
- Year and Date
  2014-12-13 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-25460990
[Presentation] Protein SはNKT細胞の活性化を介して急性アルコール性肝障害を増悪させる
- Author(s)
  諸岡留美, 岩佐元雄, 杉本龍亮, 宮地洋英, 田中秀明, 藤田尚己, 小林由直, ガバザ・エステバン , 竹井謙之
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-24590967

1. GABAZZA Esteban (00293770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. Takei Yoshiyuki (10306954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
3. FUJITA Naoki (80378398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. 中川勇人 (00555609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 江口暁子 (00598980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Iwasa Motoo 岩佐 元雄

岩佐 元雄 イワサ モトオ

IWASA Motoo 岩佐 元雄

Research Projects

Research Products

Co-Researchers

抱合胆汁酸に焦点を当てた肝筋連関の解明と肝関連サルコペニアの診断・治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胆汁酸を起点とした肝筋連関の解明と肝性サルコペニアの診断・治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the common mechanisms of tissue remodeling in nonalcoholic steatohapatitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Approaches to the pathogenesis and treatment of liver fibrosis through genetically modified mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pathophysiology and management of hepatic encephalopathy 2014 update: Ammonia toxicity and hyponatremia.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevation of branched-chain amino acid levels in diabetes and NAFL and changes with antidiabetic drug treatment2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Usefulness of Levocarnitine and/or Branched-Chain Amino Acids during Invasive Treatment for Hepatocellular Carcinoma.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Change in skeletal muscle mass after administering entecavir in patients with hepatitis B.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation and prognosis of sarcopenia using impedance analysis in patients with liver cirrhosis.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nutrition therapy using a multidisciplinary team improves survival rates in patients with liver cirrhosis.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] 主題：肝硬変合併症の基礎と臨床 リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変患者の予後を規定する2023

Author(s)

Organizer

Data Source

[Presentation] リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変患者の予後を規定する2023

Author(s)

Organizer

Data Source

[Presentation] 主題：肝疾患の病態に基づいた治療戦略 慢性肝疾患に伴う骨格筋障害における肝細胞由来臓器間病態伝達体の役割2023

Iwasa Motoo 岩佐元雄

岩佐元雄イワサモトオ

IWASA Motoo 岩佐元雄

[Presentation] 主題：肝硬変合併症の基礎と臨床　リトコール酸はTGR-5の活性化を介して骨格筋肥大を誘導し、肝硬変患者の予後を規定する2023

[Presentation] 主題：肝疾患の病態に基づいた治療戦略　慢性肝疾患に伴う骨格筋障害における肝細胞由来臓器間病態伝達体の役割2023