Tawara Isao 俵功

Researcher Number	80378380
Other IDs
Affiliation (Current)	2025: 三重大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2025: 三重大学, 医学系研究科, 教授 2020 – 2023: 三重大学, 医学系研究科, 教授 2018 – 2020: 三重大学, 医学部附属病院, 講師 2013 – 2017: 三重大学, 医学部附属病院, 助教 2016: 三重大学, 医学系研究科, 助教 2016: 三重大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 52040:Radiological sciences-related / Hematology / Basic Section 63020:Radiation influence-related / Basic Section 56070:Plastic and reconstructive surgery-related / Basic Section 49020:Human pathology-related / Pediatrics
Keywords	Principal Investigator 免疫細胞療法 / 移植片対腫瘍効果 / 造血幹細胞移植 / 移植片対宿主病 / ドナーリンパ球輸注 / 腫瘍微小環境 / 造血器腫瘍 / 固形腫瘍 / サイトカイン放出症候群 / 急性GVHD … More / 移植後再発 / 遺伝子改変T細胞輸注療法 / 特異的リンパ球輸注療法 / 同種造血幹細胞移植 / ＧＶＨＤ / Ｔ細胞受容体遺伝子改変 / 腫瘍特異的遺伝子改変免疫細胞 / 遺伝子改変リンパ球 / 遺伝子改変細胞 / 腫瘍特異的リンパ球 / 移植後腫瘍再発 / 造血細胞移植 / 慢性GVHD / テネイシン-Ｃ / テネイシン-C / GVHD … More Except Principal Investigator テネイシンC / 肺線維症 / 細胞外マトリックス / 炎症 / 抗線維化薬 / ニンテダニブ / 放射線性肺臓炎 / リンパ / 免疫 / 再生 / マウス / 放射線障害 / 放射線照射 / 心臓障害 / 慢性炎症 / 拡張型心筋症 / 心筋炎 / 肺癌 / 放射線肺臓炎 / テネイシン / 川崎病 / バイオマーカー / 動物モデル / 移植片対宿主病（GVHD） / 移植片対腫瘍効果 / 免疫抑制剤 / MEK阻害剤 / 抗ウイルス免疫 / 抗腫瘍免疫 / 移植片対宿主病 / 造血幹細胞移植 / リンパ球系細胞分化 / リンパ球分化 / LFA-1 / SDF-1 / ストローマ細胞 Less

Investigation of methods to enhance the antitumor effects of immune receptor gene-engineered cells against hematologic and solid tumorsPrincipal Investigator
- Principal Investigator
  
  俵功
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Mie University
免疫とリンパのクロストークによる組織再生の実現
- Principal Investigator
  
  小島暉理人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Mie University
Establishment of a Novel Treatment for Radiation-Induced Lung Injury Focusing on the Antifibrotic Drug Nintedanib and Development of Diagnostic Markers
- Principal Investigator
  
  高田彰憲
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Mie University
放射線性心臓障害における免疫学的機序の解明
- Principal Investigator
  
  豊増泰
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Mie University
Development of methods controlling infused lymphocytes based on the immunopathology of acute GVHD and cytokine release syndrome.Principal Investigator
- Principal Investigator
  
  Tawara Isao
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Mie University
Pathophysiology of radiation lung injury by extracellular matrix (tenascin C).
- Principal Investigator
  
  Takada Akinori
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Mie University
Elucidation of pathophysiological mechanism of chronic inflammation and risk stratification of dilated cardiomyopathy.
- Principal Investigator
  
  Imanaka-Yoshida Kyoko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Mie University
Development of preclinical models of donor-derived gene-modified lymphocyte infusion for tumor-relapse after allogeneic hematopoietic cell transplantation and evaluation of efficacy and safetyPrincipal Investigator
- Principal Investigator
  
  TAWARA Isao
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University
A study of unction of an extracellular matrix molecule which could modulate pathophysiology of Kawasaki Disease.
- Principal Investigator
  
  Imanaka-Yoshida Kyoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
Role of tenascin-C in development of fibrosis in chronic GVHD tissue and establishment of its targetted therapyPrincipal Investigator
- Principal Investigator
  
  Tawara Isao
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University
MEK inhibitors selectively suppress GVHD while sparing antitumor and antiviral immunity after allogeneic hematopoietic stem cell transplantation
- Principal Investigator
  
  Shindo Takero
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
  Saga University
Role of bone marrow niche in human early lymphopoiesis
- Principal Investigator
  
  Ohishi Kohshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University

All 2023 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS.2017
- Author(s)
  Tawara I, Kageyama S, Miyahara Y, Fujiwara H, Nishida T, Akatsuka Y, Ikeda H, Tanimoto K, Terakura S, Murata M, Inaguma Y, Masuya M, Inoue N, Kidokoro T, Okamoto S, Tomura D, Chono H, Nukaya I, Mineno J, Naoe T, Emi N, Yasukawa M, Katayama N, Shiku H.
- Journal Title
  
  Blood
  
  Volume: 130 Issue: 18 Pages: 1985-1994
- DOI
  10.1182/blood-2017-06-791202
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09307, KAKENHI-PROJECT-17K09923, KAKENHI-PROJECT-17K09949, KAKENHI-PROJECT-17K09957, KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-15H04918, KAKENHI-PROJECT-15K09497, KAKENHI-PROJECT-15K09498, KAKENHI-PROJECT-15K09506, KAKENHI-PROJECT-15K10093
[Journal Article] The MEK inhibitor trametinib separates murine Graft-versus-Host Disease from Graft-versus-Tumor Effects.2016
- Author(s)
  Itamura H, Shindo T*, Tawara I, Kubota Y, Kariya R, Okada S, Komanduri KV, Kimura S
- Journal Title
  
  JCI Insight
  
  Volume: 1 Issue: 10
- DOI
  10.1172/jci.insight.86331
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461451
[Journal Article] Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans2015
- Author(s)
  ③Choi SW, Gatza E, Hou G, Sun Y, Whitfield J, Song Y, Oravecz-Wilson K, Tawara I, Dinarello CA, Reddy P
- Journal Title
  
  Blood
  
  Volume: 125 Issue: 5 Pages: 815-819
- DOI
  10.1182/blood-2014-10-605238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461447
[Journal Article] ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease2015
- Author(s)
  Zhang J, Ramadan AM, Griesenauer B, Li W, Turner MJ, Liu C, Kapur R, Hanenberg H, Blazar BR, Tawara I, Paczesny S
- Journal Title
  
  Sci Transl Med
  
  Volume: 7 Issue: 308
- DOI
  10.1126/scitranslmed.aab0166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461447
[Journal Article] Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells.2014
- Author(s)
  Ino K, Masuya M, Tawara I, Miyata E, Oda K, Nakamori Y, Suzuki K, Ohishi K, Katayama N.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: 1-12
- DOI
  10.1371/journal.pone.0084889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460951, KAKENHI-PROJECT-25461413, KAKENHI-PROJECT-25461447
[Presentation] マウス同系腫瘍モデルにおけるCD25 陽性細胞除去T細胞輸注による腫瘍抑制効果の検討2023
- Author(s)
  塩谷拓也、加藤ななみ、王碩林、加島江美子、西村廣明、伊野和子、大石晃嗣、桝屋正浩、俵功
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08390
[Presentation] 肺部分照射デバイスを用いた放射線肺臓炎・肺線維症モデルマウスの構築2021
- Author(s)
  大森千輝、高田彰憲、野本由人、豊増泰、俵功、新徳千広、加藤大裕、吉田利通、今中恭子
- Organizer
  京大がんプロ　5大学連携医療フォーラム
- Data Source
  KAKENHI-PROJECT-19K08226
[Presentation] 肺部分照射による放射線肺臓炎・肺線維症モデルマウスの構築2020
- Author(s)
  大森千輝、高田彰憲、野本由人、豊増泰、俵功、新徳千広、加藤大裕、吉田利通、今中恭子
- Organizer
  日本放射線腫瘍学会
- Data Source
  KAKENHI-PROJECT-19K08226
[Presentation] シクロフォスファミド抵抗性腫瘍細胞株を用いたマウスMHC半合致移植モデルの作製2019
- Author(s)
  俵功、西村廣明、坪井順哉、伊野和子、景山裕紀、大石晃嗣、桝屋正浩、片山直之
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] 新しい腫瘍細胞株を用いたマウスMHC半合致骨髄移植後シクロフォスファミド投与モデル2019
- Author(s)
  俵功、伊野和子、藤枝敦史、坪井順哉、西村廣明、宮原慶裕、大石晃嗣、桝屋正浩、珠玖洋、片山直之
- Organizer
  第41回日本造血細胞移植学会総会
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] 新しい腫瘍細胞株を用いたマウスMHC半合致骨髄移植後シクロフォスファミド投与モデル2019
- Author(s)
  俵　功、伊野　和子、藤枝　敦史、坪井　順哉、西村　廣明、宮原　慶裕、大石　晃嗣、桝屋　正浩、珠玖　洋、片山　直之
- Organizer
  第41回日本造血細胞移植学会総会
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] WT1-specific TCR gene-transduced Lymphocytes2018
- Author(s)
  Isao Tawara
- Organizer
  2018 Korean Society of Experimental Hematology 5th Annual Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] Tumor-specific Donor Lymphocyte Infusion for Tumor Relapse after Hematopoietic Cell Transplantation.2017
- Author(s)
  Tawara Isao, Okamori Kana, Shiku Hiroshi, Ikeda Hiroaki, Katayama Naoyuki
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] Tumor-specific TCR-engineered Donor Lymphocytes Infusion for Tumor Relapse after Hematopoietic Stem Cell Transplantation in Mice.2017
- Author(s)
  Tawara Isao, Okamori Kana, Shiku Hiroshi, Ikeda Hiroaki, Katayama Naoyuki
- Organizer
  The 8th JSH Internationalsymposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] Tumor-Specific Donor Lymphocyte Infusion after Allogeneic Hematopoietic Stem Cell Transplantation2017
- Author(s)
  Tawara Isao, Katayama Naoyuki, Shiku Hiroshi, Ikeda Hiroaki
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] The MEK inhibitior Trametinib selectively suppresses GVHD, while sparing GVT effects.2015
- Author(s)
  板村英和、進藤岳郎、俵功、刈谷龍昇、岡田誠治、木村晋也
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  金沢市
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26461451
[Presentation] The MEK inhibitor trametinib selectively suppresses GHVD, while sparing GVT effects.
- Author(s)
  Hidekazu Itamura, Takero Shindo, Isao Tawara, Ryusho Kariya, Seiji Okada, Krishna V Komanduri, Shinya Kimura
- Organizer
  ASBMT/CIBMTR BMT Tandem Meetings
- Place of Presentation
  San Diego, CA USA
- Year and Date
  2015-02-11 – 2015-02-15
- Data Source
  KAKENHI-PROJECT-26461451

1. Imanaka-Yoshida Kyoko (00242967)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
2. Takada Akinori (80727066)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. 野本由人 (10252363)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. 豊増泰 (00725111)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Ohishi Kohshi (00397506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Nosaka Tetsuya (30218309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Kitano Shigehisa (60402682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Shindo Takero (10646706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. OKADA Seiji (50282455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. KUBOTA Yasushi (60570413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 木村晋也 (80359794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 池田裕明 (40374673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 大熊喜彰 (10609168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 勝部康弘 (20246523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 三谷義英 (60273380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 高橋啓 (80216712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 植田初江 (40522983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 田尻和子 (60633914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 奥村貴裕 (60635598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 廣江道昭 (80101872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 宇都健太 (80318071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 鈴木忠樹 (30527180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 長谷川秀樹 (30301790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 小島暉理人 (51008511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 白石真土 (00895229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 細見謙登 (90793787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 丸山和晃 (90821984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. Ito Ayumu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. MASUYA Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Tawara Isao 俵 功

Research Projects

Research Products

Co-Researchers

Investigation of methods to enhance the antitumor effects of immune receptor gene-engineered cells against hematologic and solid tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Development of methods controlling infused lymphocytes based on the immunopathology of acute GVHD and cytokine release syndrome.Principal Investigator

Principal Investigator

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Research Category

Review Section

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Principal Investigator

Project Period (FY)

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Review Section

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Principal Investigator

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Development of preclinical models of donor-derived gene-modified lymphocyte infusion for tumor-relapse after allogeneic hematopoietic cell transplantation and evaluation of efficacy and safetyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

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Role of tenascin-C in development of fibrosis in chronic GVHD tissue and establishment of its targetted therapyPrincipal Investigator

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[Journal Article] Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The MEK inhibitor trametinib separates murine Graft-versus-Host Disease from Graft-versus-Tumor Effects.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans2015

Author(s)

Tawara Isao 俵功