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Tawara Isao  俵 功

ORCIDConnect your ORCID iD *help
Researcher Number 80378380
Other IDs
Affiliation (Current) 2022: 三重大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2020 – 2021: 三重大学, 医学系研究科, 教授
2018 – 2020: 三重大学, 医学部附属病院, 講師
2013 – 2017: 三重大学, 医学部附属病院, 助教
2016: 三重大学, 医学系研究科, 助教
2016: 三重大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Hematology / Basic Section 54010:Hematology and medical oncology-related
Except Principal Investigator
Hematology / Basic Section 52040:Radiological sciences-related / Pediatrics / Basic Section 49020:Human pathology-related
Keywords
Principal Investigator
GVHD / テネイシン-C / テネイシン-C / 慢性GVHD / 造血細胞移植 / 移植後腫瘍再発 / ドナーリンパ球輸注 / 腫瘍特異的リンパ球 / 移植片対宿主病 / 造血幹細胞移植 … More / 移植片対腫瘍効果 / 遺伝子改変細胞 / 遺伝子改変リンパ球 / 腫瘍特異的遺伝子改変免疫細胞 / T細胞受容体遺伝子改変 / GVHD / 同種造血幹細胞移植 / 急性GVHD / 免疫細胞療法 / サイトカイン放出症候群 … More
Except Principal Investigator
細胞外マトリックス / ストローマ細胞 / SDF-1 / LFA-1 / リンパ球分化 / リンパ球系細胞分化 / 造血幹細胞移植 / 移植片対宿主病 / 抗腫瘍免疫 / 抗ウイルス免疫 / MEK阻害剤 / 免疫抑制剤 / 移植片対腫瘍効果 / 移植片対宿主病(GVHD) / 炎症 / 動物モデル / バイオマーカー / 川崎病 / テネイシン / 心筋炎 / 拡張型心筋症 / 慢性炎症 / 放射線肺臓炎 / 肺線維症 / テネイシンC / 放射線障害 / 心臓障害 / マウス Less
  • Research Projects

    (9 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (32 People)
  •  放射線性心臓障害における免疫学的機序の解明

    • Principal Investigator
      豊増 泰
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Mie University
  •  急性GVHDとサイトカイン放出症候群の免疫病態に着目した輸注リンパ球制御法の開発Principal Investigator

    • Principal Investigator
      俵 功
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Mie University
  •  拡張型心筋症における慢性炎症の病態メカニズムの解明と層別化

    • Principal Investigator
      吉田 恭子 (今中恭子)
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Mie University
  •  細胞外マトリックス(テネイシンC)による放射線肺障害の病態解明とその臨床応用

    • Principal Investigator
      高田 彰憲
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Mie University
  •  Development of preclinical models of donor-derived gene-modified lymphocyte infusion for tumor-relapse after allogeneic hematopoietic cell transplantation and evaluation of efficacy and safetyPrincipal Investigator

    • Principal Investigator
      TAWARA Isao
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Mie University
  •  A study of unction of an extracellular matrix molecule which could modulate pathophysiology of Kawasaki Disease.

    • Principal Investigator
      Imanaka-Yoshida Kyoko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Mie University
  •  Role of tenascin-C in development of fibrosis in chronic GVHD tissue and establishment of its targetted therapyPrincipal Investigator

    • Principal Investigator
      Tawara Isao
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Mie University
  •  MEK inhibitors selectively suppress GVHD while sparing antitumor and antiviral immunity after allogeneic hematopoietic stem cell transplantation

    • Principal Investigator
      Shindo Takero
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Kyoto University
      Saga University
  •  Role of bone marrow niche in human early lymphopoiesis

    • Principal Investigator
      Ohishi Kohshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Mie University

All 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

  • [Journal Article] Safety and persistence of WT1-specific T-cell receptor gene?transduced lymphocytes in patients with AML and MDS2017

    • Author(s)
      Tawara I, Kageyama S, Miyahara Y, Fujiwara H, Nishida T, Akatsuka Y, Ikeda H, Tanimoto K, Terakura S, Murata M, Inaguma Y, Masuya M, Inoue N, Kidokoro T, Okamoto S, Tomura D, Chono H, Nukaya I, Mineno J, Naoe T, Emi N, Yasukawa M, Katayama N, Shiku H.
    • Journal Title

      Blood

      Volume: 130 Pages: 1985-1994

    • DOI

      10.1182/blood-2017-06-791202

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09307, KAKENHI-PROJECT-17K09923, KAKENHI-PROJECT-17K09949, KAKENHI-PROJECT-17K09957, KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-15H04918, KAKENHI-PROJECT-15K09497, KAKENHI-PROJECT-15K09498, KAKENHI-PROJECT-15K09506, KAKENHI-PROJECT-15K10093
  • [Journal Article] The MEK inhibitor trametinib separates murine Graft-versus-Host Disease from Graft-versus-Tumor Effects.2016

    • Author(s)
      Itamura H, Shindo T*, Tawara I, Kubota Y, Kariya R, Okada S, Komanduri KV, Kimura S
    • Journal Title

      JCI Insight

      Volume: 1

    • DOI

      10.1172/jci.insight.86331

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461451
  • [Journal Article] Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans2015

    • Author(s)
      ③Choi SW, Gatza E, Hou G, Sun Y, Whitfield J, Song Y, Oravecz-Wilson K, Tawara I, Dinarello CA, Reddy P
    • Journal Title

      Blood

      Volume: 125 Pages: 815-819

    • DOI

      10.1182/blood-2014-10-605238

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461447
  • [Journal Article] ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease2015

    • Author(s)
      Zhang J, Ramadan AM, Griesenauer B, Li W, Turner MJ, Liu C, Kapur R, Hanenberg H, Blazar BR, Tawara I, Paczesny S
    • Journal Title

      Sci Transl Med

      Volume: 7

    • DOI

      10.1126/scitranslmed.aab0166

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461447
  • [Journal Article] Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells2014

    • Author(s)
      Ino K, Masuya M, Tawara I, Miyata E, Oda K, Nakamori Y, Suzuki K, Ohishi K, Katayama N.
    • Journal Title

      PLoS One

      Volume: 9 Pages: 1-12

    • DOI

      10.1371/journal.pone.0084889

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460951, KAKENHI-PROJECT-25461413, KAKENHI-PROJECT-25461447
  • [Presentation] 肺部分照射による放射線肺臓炎・肺線維症モデルマウスの構築2020

    • Author(s)
      大森千輝、高田彰憲、野本由人、豊増泰、俵 功、新徳千広、加藤大裕、吉田利通、今中恭子
    • Organizer
      日本放射線腫瘍学会
    • Data Source
      KAKENHI-PROJECT-19K08226
  • [Presentation] シクロフォスファミド抵抗性腫瘍細胞株を用いたマウスMHC半合致移植モデルの作製2019

    • Author(s)
      俵功、西村廣明、坪井順哉、伊野和子、景山裕紀、大石晃嗣、桝屋正浩、片山直之
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09949
  • [Presentation] 新しい腫瘍細胞株を用いたマウスMHC半合致骨髄移植後シクロフォスファミド投与モデル2019

    • Author(s)
      俵功、伊野和子、藤枝敦史、坪井順哉、西村廣明、宮原慶裕、大石晃嗣、桝屋正浩、珠玖洋、片山直之
    • Organizer
      第41回日本造血細胞移植学会総会
    • Data Source
      KAKENHI-PROJECT-17K09949
  • [Presentation] 新しい腫瘍細胞株を用いたマウスMHC半合致骨髄移植後シクロフォスファミド投与モデル2019

    • Author(s)
      俵 功、伊野 和子、藤枝 敦史、坪井 順哉、西村 廣明、宮原 慶裕、大石 晃嗣、桝屋 正浩、珠玖 洋、片山 直之
    • Organizer
      第41回日本造血細胞移植学会総会
    • Data Source
      KAKENHI-PROJECT-17K09949
  • [Presentation] WT1-specific TCR gene-transduced Lymphocytes2018

    • Author(s)
      Isao Tawara
    • Organizer
      2018 Korean Society of Experimental Hematology 5th Annual Meeting
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09949
  • [Presentation] Tumor-specific Donor Lymphocyte Infusion for Tumor Relapse after Hematopoietic Cell Transplantation.2017

    • Author(s)
      Tawara Isao, Okamori Kana, Shiku Hiroshi, Ikeda Hiroaki, Katayama Naoyuki
    • Organizer
      第79回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09949
  • [Presentation] Tumor-specific TCR-engineered Donor Lymphocytes Infusion for Tumor Relapse after Hematopoietic Stem Cell Transplantation in Mice.2017

    • Author(s)
      Tawara Isao, Okamori Kana, Shiku Hiroshi, Ikeda Hiroaki, Katayama Naoyuki
    • Organizer
      The 8th JSH Internationalsymposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09949
  • [Presentation] Tumor-Specific Donor Lymphocyte Infusion after Allogeneic Hematopoietic Stem Cell Transplantation2017

    • Author(s)
      Tawara Isao, Katayama Naoyuki, Shiku Hiroshi, Ikeda Hiroaki
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K09949
  • [Presentation] The MEK inhibitior Trametinib selectively suppresses GVHD, while sparing GVT effects.2015

    • Author(s)
      板村英和、進藤岳郎、俵功、刈谷龍昇、岡田誠治、木村晋也
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      金沢市
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-26461451
  • [Presentation] The MEK inhibitor trametinib selectively suppresses GHVD, while sparing GVT effects.

    • Author(s)
      Hidekazu Itamura, Takero Shindo, Isao Tawara, Ryusho Kariya, Seiji Okada, Krishna V Komanduri, Shinya Kimura
    • Organizer
      ASBMT/CIBMTR BMT Tandem Meetings
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2015-02-11 – 2015-02-15
    • Data Source
      KAKENHI-PROJECT-26461451
  • 1.  Imanaka-Yoshida Kyoko (00242967)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 2.  高田 彰憲 (80727066)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  野本 由人 (10252363)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  Ohishi Kohshi (00397506)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  Nosaka Tetsuya (30218309)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Kitano Shigehisa (60402682)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Shindo Takero (10646706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  OKADA Seiji (50282455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  KUBOTA Yasushi (60570413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  木村 晋也 (80359794)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 11.  池田 裕明 (40374673)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 12.  大熊 喜彰 (10609168)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  勝部 康弘 (20246523)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  三谷 義英 (60273380)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  高橋 啓 (80216712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  植田 初江 (40522983)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  田尻 和子 (60633914)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  奥村 貴裕 (60635598)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  廣江 道昭 (80101872)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  宇都 健太 (80318071)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  鈴木 忠樹 (30527180)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  長谷川 秀樹 (30301790)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  豊増 泰 (00725111)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  Ito Ayumu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  MASUYA Masahiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 26.  FUJIWARA Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  片山 直之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 28.  谷本 一史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  安川 正貴
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  寺倉 精太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  村田 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  影山 慎一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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