Tawara Isao 俵功

Researcher Number	80378380
Other IDs
Affiliation (Current)	2023: 三重大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2020 – 2021: 三重大学, 医学系研究科, 教授 2018 – 2020: 三重大学, 医学部附属病院, 講師 2013 – 2017: 三重大学, 医学部附属病院, 助教 2016: 三重大学, 医学系研究科, 助教 2016: 三重大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Hematology / Basic Section 52040:Radiological sciences-related / Pediatrics / Basic Section 49020:Human pathology-related
Keywords	Principal Investigator ドナーリンパ球輸注 / 移植片対宿主病 / 造血幹細胞移植 / 移植片対腫瘍効果 / GVHD / テネイシン-C / テネイシン-Ｃ / 慢性GVHD / 造血細胞移植 / 移植後腫瘍再発 … More / 腫瘍特異的リンパ球 / 遺伝子改変細胞 / 遺伝子改変リンパ球 / 腫瘍特異的遺伝子改変免疫細胞 / Ｔ細胞受容体遺伝子改変 / ＧＶＨＤ / 遺伝子改変T細胞輸注療法 / 同種造血幹細胞移植 / 急性GVHD / 免疫細胞療法 / サイトカイン放出症候群 … More Except Principal Investigator 炎症 / 細胞外マトリックス / ストローマ細胞 / SDF-1 / LFA-1 / リンパ球分化 / リンパ球系細胞分化 / 造血幹細胞移植 / 移植片対宿主病 / 抗腫瘍免疫 / 抗ウイルス免疫 / MEK阻害剤 / 免疫抑制剤 / 移植片対腫瘍効果 / 移植片対宿主病（GVHD） / 動物モデル / バイオマーカー / 川崎病 / テネイシン / 放射線肺臓炎 / 肺線維症 / テネイシンC / 心筋炎 / 拡張型心筋症 / 慢性炎症 / 心臓障害 / 放射線照射 / 放射線障害 / マウス Less

放射線性心臓障害における免疫学的機序の解明
- Principal Investigator
  
  豊増泰
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Mie University
急性GVHDとサイトカイン放出症候群の免疫病態に着目した輸注リンパ球制御法の開発Principal Investigator
- Principal Investigator
  
  俵功
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Mie University
細胞外マトリックス（テネイシンC）による放射線肺障害の病態解明とその臨床応用
- Principal Investigator
  
  高田彰憲
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Mie University
Elucidation of pathophysiological mechanism of chronic inflammation and risk stratification of dilated cardiomyopathy.
- Principal Investigator
  
  Imanaka-Yoshida Kyoko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Mie University
Development of preclinical models of donor-derived gene-modified lymphocyte infusion for tumor-relapse after allogeneic hematopoietic cell transplantation and evaluation of efficacy and safetyPrincipal Investigator
- Principal Investigator
  
  TAWARA Isao
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University
A study of unction of an extracellular matrix molecule which could modulate pathophysiology of Kawasaki Disease.
- Principal Investigator
  
  Imanaka-Yoshida Kyoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
Role of tenascin-C in development of fibrosis in chronic GVHD tissue and establishment of its targetted therapyPrincipal Investigator
- Principal Investigator
  
  Tawara Isao
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University
MEK inhibitors selectively suppress GVHD while sparing antitumor and antiviral immunity after allogeneic hematopoietic stem cell transplantation
- Principal Investigator
  
  Shindo Takero
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
  Saga University
Role of bone marrow niche in human early lymphopoiesis
- Principal Investigator
  
  Ohishi Kohshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University

All 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Safety and persistence of WT1-specific T-cell receptor gene?transduced lymphocytes in patients with AML and MDS2017
- Author(s)
  Tawara I, Kageyama S, Miyahara Y, Fujiwara H, Nishida T, Akatsuka Y, Ikeda H, Tanimoto K, Terakura S, Murata M, Inaguma Y, Masuya M, Inoue N, Kidokoro T, Okamoto S, Tomura D, Chono H, Nukaya I, Mineno J, Naoe T, Emi N, Yasukawa M, Katayama N, Shiku H.
- Journal Title
  
  Blood
  
  Volume: 130 Pages: 1985-1994
- DOI
  10.1182/blood-2017-06-791202
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09307, KAKENHI-PROJECT-17K09923, KAKENHI-PROJECT-17K09949, KAKENHI-PROJECT-17K09957, KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-15H04918, KAKENHI-PROJECT-15K09497, KAKENHI-PROJECT-15K09498, KAKENHI-PROJECT-15K09506, KAKENHI-PROJECT-15K10093
[Journal Article] The MEK inhibitor trametinib separates murine Graft-versus-Host Disease from Graft-versus-Tumor Effects.2016
- Author(s)
  Itamura H, Shindo T*, Tawara I, Kubota Y, Kariya R, Okada S, Komanduri KV, Kimura S
- Journal Title
  
  JCI Insight
  
  Volume: 1
- DOI
  10.1172/jci.insight.86331
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461451
[Journal Article] Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans2015
- Author(s)
  ③Choi SW, Gatza E, Hou G, Sun Y, Whitfield J, Song Y, Oravecz-Wilson K, Tawara I, Dinarello CA, Reddy P
- Journal Title
  
  Blood
  
  Volume: 125 Pages: 815-819
- DOI
  10.1182/blood-2014-10-605238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461447
[Journal Article] ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease2015
- Author(s)
  Zhang J, Ramadan AM, Griesenauer B, Li W, Turner MJ, Liu C, Kapur R, Hanenberg H, Blazar BR, Tawara I, Paczesny S
- Journal Title
  
  Sci Transl Med
  
  Volume: 7
- DOI
  10.1126/scitranslmed.aab0166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461447
[Journal Article] Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells2014
- Author(s)
  Ino K, Masuya M, Tawara I, Miyata E, Oda K, Nakamori Y, Suzuki K, Ohishi K, Katayama N.
- Journal Title
  
  PLoS One
  
  Volume: 9 Pages: 1-12
- DOI
  10.1371/journal.pone.0084889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460951, KAKENHI-PROJECT-25461413, KAKENHI-PROJECT-25461447
[Presentation] 肺部分照射デバイスを用いた放射線肺臓炎・肺線維症モデルマウスの構築2021
- Author(s)
  大森千輝、高田彰憲、野本由人、豊増泰、俵功、新徳千広、加藤大裕、吉田利通、今中恭子
- Organizer
  京大がんプロ　5大学連携医療フォーラム
- Data Source
  KAKENHI-PROJECT-19K08226
[Presentation] 肺部分照射による放射線肺臓炎・肺線維症モデルマウスの構築2020
- Author(s)
  大森千輝、高田彰憲、野本由人、豊増泰、俵功、新徳千広、加藤大裕、吉田利通、今中恭子
- Organizer
  日本放射線腫瘍学会
- Data Source
  KAKENHI-PROJECT-19K08226
[Presentation] シクロフォスファミド抵抗性腫瘍細胞株を用いたマウスMHC半合致移植モデルの作製2019
- Author(s)
  俵功、西村廣明、坪井順哉、伊野和子、景山裕紀、大石晃嗣、桝屋正浩、片山直之
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] 新しい腫瘍細胞株を用いたマウスMHC半合致骨髄移植後シクロフォスファミド投与モデル2019
- Author(s)
  俵功、伊野和子、藤枝敦史、坪井順哉、西村廣明、宮原慶裕、大石晃嗣、桝屋正浩、珠玖洋、片山直之
- Organizer
  第41回日本造血細胞移植学会総会
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] 新しい腫瘍細胞株を用いたマウスMHC半合致骨髄移植後シクロフォスファミド投与モデル2019
- Author(s)
  俵　功、伊野　和子、藤枝　敦史、坪井　順哉、西村　廣明、宮原　慶裕、大石　晃嗣、桝屋　正浩、珠玖　洋、片山　直之
- Organizer
  第41回日本造血細胞移植学会総会
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] WT1-specific TCR gene-transduced Lymphocytes2018
- Author(s)
  Isao Tawara
- Organizer
  2018 Korean Society of Experimental Hematology 5th Annual Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] Tumor-specific Donor Lymphocyte Infusion for Tumor Relapse after Hematopoietic Cell Transplantation.2017
- Author(s)
  Tawara Isao, Okamori Kana, Shiku Hiroshi, Ikeda Hiroaki, Katayama Naoyuki
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] Tumor-specific TCR-engineered Donor Lymphocytes Infusion for Tumor Relapse after Hematopoietic Stem Cell Transplantation in Mice.2017
- Author(s)
  Tawara Isao, Okamori Kana, Shiku Hiroshi, Ikeda Hiroaki, Katayama Naoyuki
- Organizer
  The 8th JSH Internationalsymposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] Tumor-Specific Donor Lymphocyte Infusion after Allogeneic Hematopoietic Stem Cell Transplantation2017
- Author(s)
  Tawara Isao, Katayama Naoyuki, Shiku Hiroshi, Ikeda Hiroaki
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09949
[Presentation] The MEK inhibitior Trametinib selectively suppresses GVHD, while sparing GVT effects.2015
- Author(s)
  板村英和、進藤岳郎、俵功、刈谷龍昇、岡田誠治、木村晋也
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  金沢市
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26461451
[Presentation] The MEK inhibitor trametinib selectively suppresses GHVD, while sparing GVT effects.
- Author(s)
  Hidekazu Itamura, Takero Shindo, Isao Tawara, Ryusho Kariya, Seiji Okada, Krishna V Komanduri, Shinya Kimura
- Organizer
  ASBMT/CIBMTR BMT Tandem Meetings
- Place of Presentation
  San Diego, CA USA
- Year and Date
  2015-02-11 – 2015-02-15
- Data Source
  KAKENHI-PROJECT-26461451

1. Imanaka-Yoshida Kyoko (00242967)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
2. 高田彰憲 (80727066)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 野本由人 (10252363)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Ohishi Kohshi (00397506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Nosaka Tetsuya (30218309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Kitano Shigehisa (60402682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Shindo Takero (10646706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. OKADA Seiji (50282455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. KUBOTA Yasushi (60570413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 木村晋也 (80359794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 池田裕明 (40374673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. 大熊喜彰 (10609168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 勝部康弘 (20246523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 三谷義英 (60273380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 高橋啓 (80216712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 植田初江 (40522983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田尻和子 (60633914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 奥村貴裕 (60635598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 廣江道昭 (80101872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 宇都健太 (80318071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 鈴木忠樹 (30527180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 長谷川秀樹 (30301790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 豊増泰 (00725111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. Ito Ayumu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MASUYA Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. FUJIWARA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 片山直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. 谷本一史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 安川正貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 寺倉精太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 村田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 影山慎一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tawara Isao 俵 功

Research Projects

Research Products

Co-Researchers

放射線性心臓障害における免疫学的機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

急性GVHDとサイトカイン放出症候群の免疫病態に着目した輸注リンパ球制御法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞外マトリックス（テネイシンC）による放射線肺障害の病態解明とその臨床応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathophysiological mechanism of chronic inflammation and risk stratification of dilated cardiomyopathy.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of preclinical models of donor-derived gene-modified lymphocyte infusion for tumor-relapse after allogeneic hematopoietic cell transplantation and evaluation of efficacy and safetyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of unction of an extracellular matrix molecule which could modulate pathophysiology of Kawasaki Disease.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of tenascin-C in development of fibrosis in chronic GVHD tissue and establishment of its targetted therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MEK inhibitors selectively suppress GVHD while sparing antitumor and antiviral immunity after allogeneic hematopoietic stem cell transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of bone marrow niche in human early lymphopoiesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Safety and persistence of WT1-specific T-cell receptor gene?transduced lymphocytes in patients with AML and MDS2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The MEK inhibitor trametinib separates murine Graft-versus-Host Disease from Graft-versus-Tumor Effects.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells2014

Author(s)

Tawara Isao 俵功