Takata Takumi 高田匠

Researcher Number	80379007
Other IDs
Affiliation (Current)	2025: 京都大学, 複合原子力科学研究所, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 京都大学, 複合原子力科学研究所, 准教授 2018 – 2019: 京都大学, 複合原子力科学研究所, 特定准教授 2016 – 2017: 京都大学, 原子炉実験所, 特定准教授 2015: 東京薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Applied health science / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator 白内障 / クリスタリン / 水晶体 / 質量分析 / 加齢 / D-アミノ酸 / 老化 / Asp異性化 / MRM法 / 異性化 … More / 翻訳後修飾 / アスパラギン酸 / タンパク質異常凝集 / 酸化 / トリプトファン / プロテオミクス / 結合型D-Asp / 抗体試薬 / プロテオーム / 加齢性疾患 / 脱アミド化 / 結合型D-アミノ酸 / タンパク質 / crystallin / D-Asp Less

蛋白質中トリプトファン残基の段階的酸化を標的とした新しい光老化科学の基盤研究Principal Investigator
- Principal Investigator
  
  高田匠
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyoto University
Innovative Research Visualizing Aging in Protein MoleculesPrincipal Investigator
- Principal Investigator
  
  Takata Takumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyoto University
加齢に応じてタンパク質中に蓄積する異性化アミノ酸残基の生理的意義を解明する研究Principal Investigator
- Principal Investigator
  
  高田匠
- Project Period (FY)
  2018
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Research Field
  
  Applied health science
- Research Institution
  Kyoto University
Isomerization of Aspartate residue as a new indicator of agingPrincipal Investigator
- Principal Investigator
  
  Takata Takumi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied health science
- Research Institution
  Kyoto University
Age-related Asp Isomerizations in Lens Alpha-crystallinPrincipal Investigator
- Principal Investigator
  
  Takata Takumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied health science
- Research Institution
  Kyoto University
  Tokyo University of Pharmacy and Life Science

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Identification of D-amino Acid Residues in Proteins Using Mass Spectrometry2022
- Author(s)
  TAKATA Takumi
- Journal Title
  
  BUNSEKI KAGAKU
  
  Volume: 71 Issue: 6 Pages: 319-324
- DOI
  10.2116/bunsekikagaku.71.319
- ISSN
  0525-1931
- Year and Date
  2022-06-05
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11646
[Journal Article] Elucidation of the mechanism of subunit exchange in αB crystallin oligomers2021
- Author(s)
  Inoue Rintaro、Sakamaki Yusuke、Takata Takumi、Wood Kathleen、Morishima Ken、Sato Nobuhiro、Okuda Aya、Shimizu Masahiro、Urade Reiko、Fujii Noriko、Sugiyama Masaaki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-9
- DOI
  10.1038/s41598-021-82250-z
- NAID
  120006956390
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06579, KAKENHI-PROJECT-20K11646, KAKENHI-PROJECT-19KK0071, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-18H05229, KAKENHI-PROJECT-17K13221, KAKENHI-PROJECT-19K16088
[Journal Article] Isomerization of Asp is essential for assembly of amyloid-like fibrils of αA-crystallin-derived peptide2021
- Author(s)
  Magami Kosuke、Hachiya Naomi、Morikawa Kazuo、Fujii Noriko、Takata Takumi
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 4 Pages: 1-12
- DOI
  10.1371/journal.pone.0250277
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22521, KAKENHI-PROJECT-20K11646
[Journal Article] Simultaneous and Rapid Detection of Multiple Epimers and Isomers of Aspartyl Residues in Lens Proteins Using an LC-MS-MRM Method2020
- Author(s)
  Fujii Noriko、Takata Takumi、Kim Ingu、Matsubara Toshiya
- Journal Title
  
  ACS Omega
  
  Volume: 5 Issue: 42 Pages: 27626-27632
- DOI
  10.1021/acsomega.0c04197
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11646, KAKENHI-PROJECT-17K13221
[Journal Article] Site‐specific rapid deamidation and isomerization in human lens αA‐crystallin in vitro2020
- Author(s)
  Takata Takumi、Ha Seongmin、Koide Tamaki、Fujii Noriko
- Journal Title
  
  Protein Science
  
  Volume: 29 Issue: 4 Pages: 941-951
- DOI
  10.1002/pro.3821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11646, KAKENHI-PROJECT-17K13221
[Journal Article] Asp isomerization increases aggregation of α-crystallin and decreases its chaperone activity in human lens of various ages2020
- Author(s)
  Fujii Noriko、Takata Takumi、Kim Ingu、Morishima Ken、Inoue Rintaro、Magami Kousuke、Matsubara Toshiya、Sugiyama Masaaki、Koide Tamaki
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  
  Volume: 1868 Issue: 9 Pages: 140446-140446
- DOI
  10.1016/j.bbapap.2020.140446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06579, KAKENHI-PROJECT-20K11646, KAKENHI-PROJECT-18H05229, KAKENHI-PROJECT-17K13221
[Journal Article] Effect of a Lens Protein in Low-Temperature Culture of Novel Immortalized Human Lens Epithelial Cells (iHLEC-NY2).2020
- Author(s)
  Yamamoto N, Takeda S, Hatsusaka N, Hiramatsu N, Nagai N, Deguchi S, Nakazawa Y, Takata T, Kodera S, Hirata A, Kubo E, Sasaki H.
- Journal Title
  
  Cells.
  
  Volume: 9 (12) Issue: 12 Pages: 2670-2670
- DOI
  10.3390/cells9122670
- NAID
  130008066407
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-20K11646, KAKENHI-PROJECT-17K13221
[Journal Article] Negative charge at aspartate 151 is important for human lens αA-crystallin stability and chaperone function.2019
- Author(s)
  Takata T, Matsubara T, Nakamura-Hirota T, Fujii N.
- Journal Title
  
  Experimental eye research.
  
  Volume: 5 Pages: 10-18
- DOI
  10.1016/j.exer.2019.02.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13221
[Journal Article] D-Amino acids in protein: The mirror of life as a molecular index of aging2018
- Author(s)
  Fujii Noriko、Takata Takumi、Fujii Norihiko、Aki Kenzo、Sakaue Hiroaki
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  
  Volume: in press Issue: 7 Pages: 840-847
- DOI
  10.1016/j.bbapap.2018.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13221, KAKENHI-PROJECT-16K16605
[Journal Article] Identification of Isomeric Aspartate residues in βB2-crystallin from Aged Human Lens2018
- Author(s)
  Takata Takumi、Murakami Kento、Toyama Atsuhiko、Fujii Noriko
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  
  Volume: in press Issue: 7 Pages: 767-774
- DOI
  10.1016/j.bbapap.2018.04.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13221
[Journal Article] Asp 58 modulates lens αA-crystallin oligomer formation and chaperone function2018
- Author(s)
  Takata Takumi、Nakamura-Hirota Tooru、Inoue Rintaro、Morishima Ken、Sato Nobuhiro、Sugiyama Masaaki、Fujii Noriko
- Journal Title
  
  The FEBS Journal
  
  Volume: in press Issue: 12 Pages: 2263-2277
- DOI
  10.1111/febs.14475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13221, KAKENHI-PROJECT-17K07361
[Journal Article] Isomeric Replacement of a Single Aspartic Acid Induces a Marked Change in Protein Function: The Example of Ribonuclease A2017
- Author(s)
  Sakaue H, Kinouchi T, Fujii N, Takumi T, Fujii N.
- Journal Title
  
  ACS Omega
  
  Volume: 2 Issue: 1 Pages: 260-267
- DOI
  10.1021/acsomega.6b00346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25288075, KAKENHI-PROJECT-15K16514, KAKENHI-PROJECT-16K00600, KAKENHI-PROJECT-16K16605, KAKENHI-PROJECT-17K13221
[Journal Article] Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide.2017
- Author(s)
  Nagai N, Kotani S, Mano Y, Ueno A, Ito Y, Kitaba T, Takata T and Fujii N.
- Journal Title
  
  Biomed. Res. Int.
  
  Volume: - Pages: 1-9
- DOI
  10.1155/2017/5343010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K16514, KAKENHI-PROJECT-17K13221
[Journal Article] Identification of ?-amino acid-containing peptides in human serum2017
- Author(s)
  Ha Seongmin、Kim Ingu、Takata Takumi、Kinouchi Tadatoshi、Isoyama Masaharu、Suzuki Minoru、Fujii Noriko
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 12 Pages: e0189972-e0189972
- DOI
  10.1371/journal.pone.0189972
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K13221
[Journal Article] Aggregation of Trp > Glu point mutants of human gamma-D crystallin provides a model for hereditary or UV-induced cataract.2016
- Author(s)
  Serebryany E, Takata T, Erickson E, Schafheimer N, Wang Y, King JA.
- Journal Title
  
  Protein science.
  
  Volume: 6 Issue: 6 Pages: 1115-1128
- DOI
  10.1002/pro.2924
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16514
[Journal Article] Isomerization of Asp residues plays an important role in αA-crystallin dissociation.2016
- Author(s)
  Takata T, Fujii N.
- Journal Title
  
  FEBS J.
  
  Volume: 283 Issue: 5 Pages: 850-859
- DOI
  10.1111/febs.13635
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K16514, KAKENHI-PROJECT-25288075
[Journal Article] New insight into the dynamical system of αB-crystallin oligomers2016
- Author(s)
  R. Inoue, T. Takata, N. Fujii, K. Ishii, S. Uchiyama, N. Sato, Y. Oba, K. Wood, K. Kato, N. Fujii, and M. Sugiyama
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 29208-29208
- DOI
  10.1038/srep29208
- NAID
  120006323745
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H00766, KAKENHI-PUBLICLY-16H00770, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-15H02042, KAKENHI-PROJECT-25288075, KAKENHI-PROJECT-15K16514, KAKENHI-PROJECT-15K18515, KAKENHI-INTERNATIONAL-15K21708
[Journal Article] Effect of Asp 96 isomerization on the properties of a lens αB-crystallin-derived short peptide.2015
- Author(s)
  Takata T, Fujii N.
- Journal Title
  
  J Pharm Biomed Anal.
  
  Volume: 116 Pages: 139-144
- DOI
  10.1016/j.jpba.2015.06.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16514, KAKENHI-PROJECT-25288075
[Presentation] Rapid deamidation/isomerization of Asparagine residues and effect of C-terminal adjacent amino acid residues in human lens αA-crystallin2022
- Author(s)
  Takumi Takata, Haruna Sugawa
- Organizer
  The XXV Biennial Meeting International Society for Eye Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] Effect of C-terminal adjacent amino acid residues on deamidation/isomerization of asparagine residues in lens component proteins2022
- Author(s)
  Takumi Takata
- Organizer
  Fifth International Conference on D-Amino Acid Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] たんぱく質の中にある年輪新しい老化の指標について2021
- Author(s)
  高田匠
- Organizer
  アトムサイエンスフェア講演会2021
- Invited
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] Oligomer structure and formation kinetics of cataract-associated proteins revealed with native ion mobility-mass spectrometry2021
- Author(s)
  Amber D Rolland, Takumi Takata, Micah T. Donor, Samuel G. Wheeler, Larry L. David, Kirsten J. Lampi, James S. Prell
- Organizer
  69th American Society for Mass Spectrometry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] βB1-クリスタリン中のアスパラギン酸残基の異性化2021
- Author(s)
  加賀澤悠太, 金仁求, 高田匠
- Organizer
  第60回日本白内障学会総会・第47回水晶体研究会合同大会
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] 迅速にAsp異性化反応が進行するモデル蛋白質の作出と評価2021
- Author(s)
  高田匠
- Organizer
  第16回 D-アミノ酸学会学術講演会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] Asp残基異性化に応じたα-クリスタリン由来ペプチドの機能及び構造の変化2021
- Author(s)
  高田匠, 眞上晃輔
- Organizer
  第60回日本白内障学会総会・第47回水晶体研究会合同大会
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] Subunit dynamics in alpha-crystallin through deuteration-assisted small-angle neutron scattering2021
- Author(s)
  Inoue, Rintaro, Sakamaki, Yusuke, Takata, Takumi, Morishima, Ken, Wood, Kathleen, Sato, Nobuhiro, Okuda, Aya, Shimizu, Masahiro, Urade, Reiko, Fujii, Noriko, Sugiyama, Masaaki
- Organizer
  XXV General Assembly and Congress of the International Union of Crystallography - IUCr 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] The Effects of Isomerization and Racemization of Asp Residues for Polypeptide Properties2020
- Author(s)
  Takumi Takata, Naomi Hachiya and Noriko Fujii
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] クリスタリン内部アミノ酸の翻訳後修飾からみる水晶体老化2020
- Author(s)
  高田匠
- Organizer
  第59回日本白内障学会総会・第46回水晶体研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] αA-クリスタリン中のAsp151をAsnに置換した組換え体では、同部位の異性化が10倍速く進行する2020
- Author(s)
  高田匠 , 藤井紀子
- Organizer
  第59回日本白内障学会総会・第46回水晶体研究会
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] クリスタリン内部アミノ酸の翻訳後修飾からみる水晶体老化2020
- Author(s)
  高田匠
- Organizer
  第59回日本白内障学会総会・第46回水晶体研究会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] 蛋白質結合型のアスパラギン酸残基の異性化修飾について2020
- Author(s)
  高田匠 , 藤井紀子
- Organizer
  第71回日本電気泳動学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] αA-クリスタリン中のAsp151をAsnに置換した組換え体では、同部位の異性化が10倍速く進行する2020
- Author(s)
  高田匠 , 藤井紀子
- Organizer
  第59回日本白内障学会総会・第46回水晶体研究会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] The Effects of Isomerization and Racemization of Asp Residues for Polypeptide Properties2020
- Author(s)
  Takumi Takata, Naomi Hachiya, Noriko Fujii
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K11646
[Presentation] 蛋白質結合型のアスパラギン酸残基の異性化修飾について2020
- Author(s)
  高田匠 , 藤井紀子
- Organizer
  第71回日本電気泳動学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] Creation and analysis of isomers-containing lens αA-crystallin2019
- Author(s)
  Takumi Takata, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama and Noriko Fujii
- Organizer
  The 6th International Conference on the Lens.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] Lens β-crystallins preferentially form hetero-oligomers2019
- Author(s)
  K. J. Lampi, M. Donor, T. Takata, C. Vetter, L. L. David, and J. Prell.
- Organizer
  The Association For Research in Vision and Ophthalmology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] クリスタリン中の複数箇所で見られるAsp異性体の一斉分析2019
- Author(s)
  藤井紀子, 高田匠, 金仁求, 松原稔哉
- Organizer
  第58回日本白内障学会総会・第45回水晶体研究会合同大会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] 多重反応モニタリング(MRM)法を用いた老化蛋白質中のD-アミノ酸分析2019
- Author(s)
  藤井紀子, 高田匠, 金仁求, 松原稔哉
- Organizer
  日本プロテオーム学会2019年大会第70回日本電気泳動学会総会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] CREATION OF ASP-ISOMER-CONTAINING LENS alphaA-CRYSTALLIN USING THE EXPRESSED PROTEIN LIGATION2019
- Author(s)
  T. Takata, H. Sakaue, and N. Fujii.
- Organizer
  The 4th International Conference of D-amino acid Research.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] ISOMERIZATION OF ASP INCREASES THE AGGREGATION OF CRYSTALLIN AND DECREASES THE CHAPERONE FUNCTION OF CRYSTALLIN2019
- Author(s)
  N. Fujii, T. Takata, I. Kim, R. Inoue, K. Morishima, K. Magami, and M. Sugiyama.
- Organizer
  The 4th International Conference of D-amino acid Research.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] A SINGLE ASP-ISOMER SUBSTITUTION IN AN ALPHA A-CRYSTALLIN-DERIVED PEPTIDE INDUCES A LARGE CHANGE IN PEPTIDE PROPERTIES2019
- Author(s)
  K. Magami, T. Kinouchi, I. Kim, T. Takata, and N. Fujii.
- Organizer
  The 4th International Conference of D-amino acid Research.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] Asp151部位へAsp異性体を導入したαA-クリスタリンの作出2019
- Author(s)
  高田匠, 藤井紀子
- Organizer
  第58回日本白内障学会総会・第45回水晶体研究会合同大会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] D-アミノ酸で語る新しい老化サイエンス2019
- Author(s)
  高田匠
- Organizer
  第14回京都大学附置研究・センターシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] β-クリスタリン中のアスパラギン酸残基の異性化2018
- Author(s)
  金仁求, 高田匠, 加治優一, 藤井紀子
- Organizer
  第14回 D-アミノ酸学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] Asp76異性化によるαA-crystallin由来ペプチドαA66-80の機能変化2018
- Author(s)
  眞上晃輔, 木野内忠稔, 金仁求, 高田匠, 藤井紀子
- Organizer
  第14回 D-アミノ酸学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] Isomerization and racemization hotspots in lens αA-crystallin2018
- Author(s)
  Takumi Takata and Noriko Fujii
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] β-クリスタリン中のアスパラギン酸残基の異性化2018
- Author(s)
  金仁求, 高田匠, 加治優一, 藤井紀子
- Organizer
  第57回日本白内障学会総会・第44回水晶体研究会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] ヒト水晶体内α A- クリスタリン中における Asp151 部位の重要性2018
- Author(s)
  高田匠, 藤井紀子
- Organizer
  第57回日本白内障学会総会・第44回水晶体研究会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] クリスタリンの凝集とアスパラギン酸の異性化2018
- Author(s)
  藤井紀子, 高田匠, 金仁求, 守島健, 井上倫太郎, 眞上晃輔, 杉山正明
- Organizer
  第14回 D-アミノ酸学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] The Site-specific Impact of Modifications of Aspartate Residues on Lens αA-Crystallin2018
- Author(s)
  Takumi Takata, Rintaro Inoue, Ken Morishima, Nobuhiro Sato, Masaaki Sugiyama, and Noriko Fujii
- Organizer
  The Association for Research in Vision and Ophthalmology 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] The Mutation Studies for Isomerization Hot spots of Aspartate Residues in Lens αA-Crystallin2018
- Author(s)
  Takumi Takata and Noriko Fujii
- Organizer
  ISER 2018 XXIII Biennial Meeting of the International Society for Eye Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] ヒト水晶体内αA-クリスタリン中のAsp151残基異性化について2018
- Author(s)
  高田匠, 藤井紀子
- Organizer
  第14回 D-アミノ酸学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] Age-related abnormal Asp isomers distribution in lens specific αA-crystallin monomeric and polymeric state2017
- Author(s)
  Takumi Takata and Noriko Fujii
- Organizer
  The 3rd International Conference of D-Amino Acid Research
- Place of Presentation
  Varese, Italy
- Year and Date
  2017-07-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16514
[Presentation] The loss of chaperone activity of human lens αA-crystallin-derived peptide 66-80 is dramatically recovered by the replacement of Lβisomer at Asp762017
- Author(s)
  Kosuke Magami, Takumi Takata, Iugu Kim, Noriko Fujii
- Organizer
  International Conference on the Lens 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] A single aspartyl isomer at a specific site induces a change in protein function2017
- Author(s)
  Hiroaki Sakaue, Tadatoshi Kinouchi, Takumi Takata, Noriko Fujii
- Organizer
  The 3rd International Conference of D-Amino Acid Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] Age-related abnormal Asp 58 isomers distribution in lens αA-crystallin2017
- Author(s)
  Takumi Takata, Noriko Fujii
- Organizer
  The 3rd International Conference of D-Amino Acid Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] 加齢に応じた水晶体機能の低下に関与するアスパラギン酸の異性化修飾2017
- Author(s)
  高田匠, 藤井紀子
- Organizer
  第90回　日本生化学会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] LC-MS/MSによる白内障クリスタリンの翻訳後修飾の一斉分析2017
- Author(s)
  金仁求, 高田匠, 加治優一, 藤井紀子
- Organizer
  第56回日本白内障学会総会・第43回水晶体研究会合同大会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] The mechanism of D-amino acid formation in proteins and new method of protein-bound D-amino acid detection2017
- Author(s)
  Noriko Fujii, Takumi Takata, Norihiko Fujii, Kenzo Aki, Hiroaki Sakaue
- Organizer
  The 3rd International Conference of D-Amino Acid Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] αA-クリスタリン66-80ペプチド中でのAsp76の異性化によるペプチドの機能変化2017
- Author(s)
  眞上晃輔, 高田匠, 金仁求, 木野内忠稔, 藤井紀子
- Organizer
  第90回　日本生化学会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] 水晶体構成タンパク質中のアミノ酸の翻訳後修飾が引き起こす白内障発祥の機構解明に関する研究2017
- Author(s)
  高田匠
- Organizer
  第56回日本白内障学会総会・第43回水晶体研究会合同大会受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] Analysis of the post-translational modifications of the individual amino acids in lens proteins which were induced by irradiation and aging2017
- Author(s)
  Ingu Kim, Takumi Takata, Noriko Fujii
- Organizer
  The 3rd International Conference of D-Amino Acid Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] ヒト血清中のD-アミノ酸含有ペプチド同定2017
- Author(s)
  Seongmin H, Ingu Kim, 高田匠, 藤井紀子
- Organizer
  第90回　日本生化学会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] αA-クリスタリンの部分ペプチドを用いたAsp58の異性化速度に関するｐＨの影響2017
- Author(s)
  石原和樹, 金仁求, 高田匠, 藤井紀子
- Organizer
  第90回　日本生化学会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] alphaA-クリスタリン相互作用能に関与するAsp異性化2017
- Author(s)
  高田匠, 金仁求, 藤井紀子
- Organizer
  第56回日本白内障学会総会・第43回水晶体研究会合同大会
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] Age-related modification of Asp58 and Asp151 in lens αA-crystallin contributes to cataract formation2017
- Author(s)
  Takumi Takata, Noriko Fujii
- Organizer
  International Conference on the Lens 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13221
[Presentation] Age-related Asp Isomerization in Dissociated Alpha-crystallin from Aged Lens2016
- Author(s)
  Takumi Takata, Takashi Sato, Noriko Fujii
- Organizer
  ARVO 2016
- Place of Presentation
  Seattle, USA
- Year and Date
  2016-04-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16514
[Presentation] Age-related abnormal Asp isomers distribution in lens specific αA-crystallin monomeric and polymeric state2016
- Author(s)
  Takumi Takata, Takashi Sato, Hiroshi Sasaki and Noriko Fujii
- Organizer
  XXII Biennial Meeting of the International Society for Eye Research
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2016-09-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16514
[Presentation] 加齢後のヒト水晶体内におけるαA-クリスタリン単量体内と会合体内のAsp異性化率の相違2015
- Author(s)
  高田匠, 藤井紀子
- Organizer
  第11回D-アミノ酸学会
- Place of Presentation
  長岡
- Year and Date
  2015-09-14
- Data Source
  KAKENHI-PROJECT-15K16514
[Presentation] Isomerization of Asp residues is different between monomer and hetero-polymer of alpha-crystallin in aged human lens.2015
- Author(s)
  T. Takata and N Fujii.
- Organizer
  International Conference on the Lens 2015.
- Place of Presentation
  Kona, USA
- Year and Date
  2015-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16514

1. INOUE Rintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. NAGAI Noriaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 木野内忠稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 藤井紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 杉山正明

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 八谷如美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 山本直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 平松範子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takata Takumi 高田 匠

Research Projects

Research Products

Co-Researchers

蛋白質中トリプトファン残基の段階的酸化を標的とした新しい光老化科学の基盤研究Principal Investigator

Principal Investigator

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Innovative Research Visualizing Aging in Protein MoleculesPrincipal Investigator

Principal Investigator

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Review Section

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加齢に応じてタンパク質中に蓄積する異性化アミノ酸残基の生理的意義を解明する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isomerization of Aspartate residue as a new indicator of agingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Age-related Asp Isomerizations in Lens Alpha-crystallinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Identification of D-amino Acid Residues in Proteins Using Mass Spectrometry2022

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Data Source

[Journal Article] Elucidation of the mechanism of subunit exchange in αB crystallin oligomers2021

Author(s)

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NAID

Data Source

[Journal Article] Isomerization of Asp is essential for assembly of amyloid-like fibrils of αA-crystallin-derived peptide2021

Author(s)

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DOI

Data Source

[Journal Article] Simultaneous and Rapid Detection of Multiple Epimers and Isomers of Aspartyl Residues in Lens Proteins Using an LC-MS-MRM Method2020

Author(s)

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[Journal Article] Site‐specific rapid deamidation and isomerization in human lens αA‐crystallin in vitro2020

Author(s)

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[Journal Article] Asp isomerization increases aggregation of α-crystallin and decreases its chaperone activity in human lens of various ages2020

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[Journal Article] Effect of a Lens Protein in Low-Temperature Culture of Novel Immortalized Human Lens Epithelial Cells (iHLEC-NY2).2020

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NAID

Data Source

[Journal Article] Negative charge at aspartate 151 is important for human lens αA-crystallin stability and chaperone function.2019

Author(s)

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Data Source

[Journal Article] D-Amino acids in protein: The mirror of life as a molecular index of aging2018

Takata Takumi 高田匠

[Presentation] たんぱく質の中にある年輪新しい老化の指標について2021