Kobayashi Sakiko 小林佐紀子

… Alternative Names

KOBAYASHI Sakiko 小林佐紀子

小林佐紀子コバヤシサキコ

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Researcher Number	80383727
External Links
Affiliation (Current)	2025: 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 医長
Affiliation (based on the past Project Information) *help	2017 – 2020: 慶應義塾大学, 医学部(信濃町), 特任講師 2016: 慶應義塾大学, 医学部(信濃町), 特任助教 2015: 慶應義塾大学, 医学部, 助教 2013: 慶應義塾大学, 医学部, 共同研究員 2012: 慶應義塾大学, 医学部, その他 2006: 慶應大, 医学部, 助手 2005: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Endocrinology / Basic Section 53040:Nephrology-related / Kidney internal medicine Except Principal Investigator Endocrinology
Keywords	Principal Investigator ミネラルコルチコイド受容体 / 高血圧 / 転写共役因子 / 相互作用因子 / LSD1 / MR / 食塩感受性高血圧 / 生活習慣病 / エピゲノム / 肥満 … More / 内臓脂肪 / 肥満症 / 高血圧症 / 特発性アルドステロン症 / 原発性アルドステロン症 / アルドステロン / Yeast two-hybrid system … More Except Principal Investigator Nurr1 / signal transduction / aldosterone synthase / aldosterone / SUMO化 / 副腎皮質 / シグナル伝達 / アルドステロン合成酵素 / Nurrl / アルドステロン Less

Regulation of MR activity by a novel transcriptional coactivator, LSD1, and its significance in the development of salt-sensitive hypertensionPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Sakiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Keio University
The role of TET2 in mineralocorticoid receptor mediated transcription through epigenetic mechanisms and development of hypertensionPrincipal Investigator
- Principal Investigator
  
  Kobayashi Sakiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Investigation of Serum Aldosterone Inducing Factors in Patients with Idiopathic HyperaldosteronismPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Sakiko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Keio University
心臓におけるミネラルコルチコイド受容体(MR)作用の分子機構の検討Principal Investigator
- Principal Investigator
  
  小林佐紀子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Keio University
Regulation of aldosterone synthesis by nuclear receptor Nurr1
- Principal Investigator
  
  SHIBATA Hirotaka
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  KEIO UNIVERSITY

All 2020 2019 2018 2017 2016 2015 2013

All Journal Article Presentation Book

[Book] Hospitalist2016
- Author(s)
  小林佐紀子
- Total Pages
  5
- Publisher
  メディカル・サイエンス・インターナショナル
- Data Source
  KAKENHI-PROJECT-15K09296
[Book] Medical Practice2016
- Author(s)
  小林佐紀子
- Total Pages
  6
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-15K09296
[Book] HORMONE FRONTIER IN GYNECOLOGY2015
- Author(s)
  小林佐紀子、伊藤裕
- Total Pages
  5
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15K09296
[Journal Article] 臓器連関の実態　CKDと内分泌疾患2020
- Author(s)
  小林　佐紀子
- Journal Title
  
  内科
  
  Volume: 126 Pages: 261-264
- Data Source
  KAKENHI-PROJECT-18K08250
[Journal Article] 不妊治療（生殖補助医療）希望の甲状腺機能正常者、橋本病患者2019
- Author(s)
  小林佐紀子
- Journal Title
  
  日本甲状腺学会雑誌
  
  Volume: 10 Pages: 108-113
- Data Source
  KAKENHI-PROJECT-18K08250
[Journal Article] Epidermal growth factor receptor/extracellular signal-regulated kinase pathway enhances mineralocorticoid receptor transcriptional activity through protein stabilization2018
- Author(s)
  Mitsuishi Yuko、Shibata Hirotaka、Kurihara Isao、Kobayashi Sakiko、Yokota Kenichi、Murai-Takeda Ayano、Hayashi Takeshi、Jo Rie、Nakamura Toshifumi、Morisaki Mitsuha、Itoh Hiroshi
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: in press Pages: 30017-30017
- DOI
  10.1016/j.mce.2018.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09734, KAKENHI-PROJECT-17H06270, KAKENHI-PROJECT-15K09296, KAKENHI-PROJECT-18K16007
[Journal Article] Intestinal Mineralocorticoid Receptor Contributes to Epithelial Sodium Channel?Mediated Intestinal Sodium Absorption and Blood Pressure Regulation2018
- Author(s)
  Nakamura Toshifumi、Kurihara Isao、Kobayashi Sakiko、Yokota Kenichi、Murai‐Takeda Ayano、Mitsuishi Yuko、Morisaki Mitsuha、Kohata Nao、Oshima Yosuke、Minami Yukiko、Shibata Hirotaka、Itoh Hiroshi
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 7 Issue: 13
- DOI
  10.1161/jaha.117.008259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09734, KAKENHI-PROJECT-18K08250, KAKENHI-PROJECT-18K16007, KAKENHI-PROJECT-16K09656, KAKENHI-PROJECT-17K16095
[Journal Article] A case of familial dysalbuminemic hyperthyroxinemia (FDH) in Japan: FDH as a possible differential diagnosis of syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH)2017
- Author(s)
  1.Kobayashi S, Yoshimura Noh J, Shimizu T, Sato T, Kurihara I, Sugino K, Itoh H, Ito K
- Journal Title
  
  Endocr J
  
  Volume: 64 Issue: 2 Pages: 207-212
- DOI
  10.1507/endocrj.EJ16-0135
- NAID
  130005397073
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09296
[Journal Article] Adrenal Insufficiency under Standard Dosage of Glucocorticoid Replacement after Unilateral Adrenalectomy for Cushing's Syndrome.2016
- Author(s)
  Fujii K, Miyashita K, Kurihara I, Hiratsuka K, Sato S, Yokota K, Kobayashi S, Shibata H, Itoh H.
- Journal Title
  
  Case Rep Endocrinol
  
  Volume: 2016 Pages: 2347528-2347528
- DOI
  10.1155/2016/2347528
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09296
[Journal Article] Radioiodine-Associated Exacerbation of Graves' Orbitopathy in the Japanese Population: Randomized Prospective Study.2015
- Author(s)
  Watanabe N, Noh JY, Kozaki A, Iwaku K, Sekiya K, Kosuga Y, Matsumoto M, Suzuki M, Yoshihara A, Ohye H, Kobayashi S, Kunii Y, Mukasa K, Sugino K, Inoue T, Ito K.
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 100(7) Issue: 7 Pages: 2700-2708
- DOI
  10.1210/jc.2014-4542
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09296
[Journal Article] Substituting Potassium Iodide for Methimazole as the Treatment for Graves' Disease During the First Trimester May Reduce the Incidence of Congenital Anomalies: A Retrospective Study at a Single Medical Institution in Japan.2015
- Author(s)
  Yoshihara A, Noh JY, Watanabe N, Mukasa K, Ohye H, Suzuki M, Matsumoto M, Kunii Y, Suzuki N, Kameda T, Iwaku K, Kobayashi S, Sugino K, Ito K.
- Journal Title
  
  Thyroid
  
  Volume: 25(10) Issue: 10 Pages: 1155-1161
- DOI
  10.1089/thy.2014.0581
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] 薬物治療下で心肥大と心機能低下の進行を認めたアルドステロン産生腺腫の1例2020
- Author(s)
  安田格、栗原勲、宮下和季、小林佐紀子、横田健一、三石木綿子、川合未来、伊藤智章、吉本憲史、安田麻里絵、武田利和、伊藤裕
- Organizer
  第21回日本内分泌学会関東甲信越支部学術集会
- Data Source
  KAKENHI-PROJECT-18K08250
[Presentation] 2回目以上の抗甲状腺薬の内服時に無顆粒球症を発症した症例における初回投与時と無顆粒球症発症時の抗甲状腺薬の内服量の検討2020
- Author(s)
  小林佐紀子、吉村弘、渡邊奈津子、吉原愛、鈴木美穂、松本雅子、國井葉、栗原勲、杉野公則、伊藤公一、伊藤裕
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08250
[Presentation] 当院にて低侵襲副腎ラジオ波アブレーション治療を行った原発性アルドステロン症の年次経過　2019年報告2020
- Author(s)
  川合未来、栗原勲、宮下和季、小林佐紀子、横田健一、髙畑尚、上妻嵩英、鳥光拓人、高瀬圭、中塚誠之、伊藤裕
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08250
[Presentation] アミオダロン投与下における甲状腺機能の検討2020
- Author(s)
  杉山和俊、小林佐紀子、栗原勲、宮下和季、横田健一、河野隆志、伊藤裕
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08250
[Presentation] 原発性アルドステロン症における微量アルブミン尿の性差および閉経前後の比較2019
- Author(s)
  南悠季子、栗原勲、小林佐紀子、横田健一、伊藤裕
- Organizer
  第19回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-18K08250
[Presentation] 原発性アルドステロン症の副腎部分切除術選択における区域別副腎静脈サンプリングの有用性2019
- Author(s)
  乃村元子、栗原勲、小林佐紀子、横田健一、宮下和季、武田彩乃、三石木綿子、高畑尚、南悠季子、齋藤洸平、上妻嵩英、中塚誠之、武田利和、伊藤裕
- Organizer
  臨床高血圧フォーラム
- Data Source
  KAKENHI-PROJECT-18K08250
[Presentation] FDG-PETにおける両側副腎の集積亢進を契機に原発性アルドステロン症の診断に至った一例2019
- Author(s)
  大島洋一、栗原勲、横田健一、小林佐紀子、武田彩乃、三石木綿子、宮下和季、伊藤裕
- Organizer
  第42回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-18K08250
[Presentation] 高齢者における機能的副腎腫瘍の治療2019
- Author(s)
  横田健一、栗原勲、宮下和季、小林佐紀子、乃村元子、伊藤裕
- Organizer
  第19回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-18K08250
[Presentation] 潜在性甲状腺機能低下症と治療の適応2019
- Author(s)
  小林佐紀子
- Organizer
  第52回日本内分泌外科学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08250
[Presentation] Comparison of the efficacy of laparoscopic partial adrenalectomy and total adrenalectomy in the surgical treatment of primary aldosteronism - the result of a single institution in Japan2019
- Author(s)
  Motoko Nomura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Kazutoshi Miyashita, Ayano Murai Takeda, Yuko Mitsuishi, Nao Kohata, Yukiko Minami, Kohei Saito, Takahide Kozuma, Seishi Nakatsuka, Toshikazu Takeda, Hiroshi Itoh
- Organizer
  International Aldosterone Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08250
[Presentation] Adrenal Cysts with High Aldosterone Levels in Cystic Fluid: A Clinicopathological Study of 5 Adrenal Cyst Cases Using CYP11B2 Immunohistochemistry2018
- Author(s)
  N Kohata, I Kurihara, S Kobayashi, K Yokota, Y Mitsuishi, M Morisaki, Y Oshima, Y Koike, K Saitoh, K Kameyama, H Itoh
- Organizer
  43rd Meeting of the International Aldosterone Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] Usefulness of Dexamethasone Suppression Test in the Diagnosis of Primary Aldosteronism Subtypes2018
- Author(s)
  M Nomura, S Kobayashi, I Kurihara, K Miyashita, K Yokota,A Murai-Takeda, T Nakamura, M Morisaki, N Kohata, Y Oshima, Y Minami, K Saitoh, H Itoh
- Organizer
  43rd Meeting of the International Aldosterone Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] Essential role of intestinal epithelial mineralocorticoid receptor in the regulation of sodium absorption and blood pressure.2016
- Author(s)
  143.Toshifumi Nakamura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Yuko Mitsuishi, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Gunther Schutz, Hirotaka Shibata, Hiroshi Itoh
- Organizer
  The 26th Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  韓国（ソウル）
- Year and Date
  2016-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] 腸管上皮ミネラルコルチコイド受容体は腸管ENaCを介したNa吸収により血圧を調節する2016
- Author(s)
  136.中村俊文, 栗原勲, 小林佐紀子, 横田健一, 武田彩乃, 城理絵, 三石木綿子, 盛崎瑞葉, 高畑尚, 大嶋洋佑, 伊藤裕
- Organizer
  第53回日本臨床分子医学会学術総会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-04-11
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] 原発性アルドステロン症の病態と内臓脂肪量の関連性の検討2016
- Author(s)
  137.栗原勲, 大山貴子, 小林佐紀子, 横田健一, 武田彩乃, 三石木綿子, 城理絵, 中村俊文, 盛崎瑞葉, 柴田洋孝, 伊藤裕
- Organizer
  第34回日本肥満症治療学会学術集会
- Place of Presentation
  東京コンベンションホール(東京都中央区）
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] Cases of Aldosterone-producing Adenomas which were Cured by Radiofrequency Ablation: Ongoing Confirmatory Clinical Study for Efficacy and Safety.2016
- Author(s)
  141.Sakiko Kobayashi, Isao Kurihara, Kenichi Yokota, Ayano Murai-Takeda, Yuko Mitsuishi, Toshifumi Nakamura, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Sota Oguro, Kazutoshi Miyashita, Hiroshi Itoh, Hirotaka Shibata, Hiroshi Itoh
- Organizer
  The 26th Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  韓国(ソウル）
- Year and Date
  2016-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] MR Sensitivity is enhanced in High Fat Diet Mice under Equally-adjusted Salt Intake.2016
- Author(s)
  144.Mitsuha Morisaki, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Rie Jo, Yuko Mitsuishi, Toshifumi Nakamura, Nao Kohata, Yosuke Oshima, Hirotaka Shibata, Hiroshi Itoh
- Organizer
  The 26th Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  韓国(ソウル）
- Year and Date
  2016-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] The effectiveness of levothyroxine therapy targeting thyrotropin level less than 2.5 mU/l during the first trimester in preventing miscarriage : a prospective study at a single institution2015
- Author(s)
  Sakiko Kobayashi, Jaeduk Noh, Natsuko Watanabe, Ai Yoshihara, Isao Kurihara, Koichi Ito, Hiroshi Ito
- Organizer
  International Thyroid Congress
- Place of Presentation
  Florida, USA
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] 高脂肪食負荷マウスの副腎におけるアルドステロン合成酵素発現の検討2015
- Author(s)
  盛崎瑞葉, 栗原勲, 小林佐紀子, 横田健一, 城理絵, 武田彩乃, 三石木綿子, 中村俊文, 高畑尚, 伊藤裕
- Organizer
  第88回日本内分泌学会
- Place of Presentation
  ホテルニューオータニ（東京都港区）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] 妊娠中のレボチロキシンナトリウムによる補充療法の妊娠転帰に与える影響2015
- Author(s)
  小林佐紀子, 吉村弘, 向笠浩司, 國井葉, 大江秀美, 渡邊奈津子, 松本雅子, 吉原愛, 栗原勲, 伊藤公一, 伊藤裕
- Organizer
  日本内分泌学会
- Place of Presentation
  ホテルニューオータニ（東京都港区）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] 新規ミネラルコルチコイド受容体(MR)結合因子Evi1は転写共役因子としてMR活性を調節する2015
- Author(s)
  中村俊文, 栗原勲, 城理絵, 小林佐紀子, 横田健一, 武田彩乃, 三石木綿子, 盛崎瑞葉, 高畑尚, 伊藤裕
- Organizer
  日本高血圧学会
- Place of Presentation
  ひめぎんホール（愛媛県松山市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] 複数の腫瘍があるPAにおける超選択的副腎静脈サンプリングの意義2015
- Author(s)
  大嶋洋佑, 栗原勲, 宮下和季, 小林佐紀子, 横田健一, 城理絵, 門松賢, 武田彩乃, 小黒草太, 宮嶋哲, 亀山香織, 伊藤裕
- Organizer
  臨床内分泌代謝update
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-15K09296
[Presentation] 特発性アルドステロン症の病態における患者血清因子と内臓脂肪の役割2013
- Author(s)
  大山貴子, 栗原勲, 小林佐紀子, 横田健一, 三石木綿子, 城理絵, 中村俊文, 宮下和季, 柴田洋孝, 伊藤裕
- Organizer
  平成25年度東京高血圧研究会
- Place of Presentation
  東京
- Year and Date
  2013-09-28
- Data Source
  KAKENHI-PROJECT-24790953
[Presentation] 肥満を伴う両側性原発性アルドステロン症の病態における患者血清因子の役割2013
- Author(s)
  大山貴子, 柴田洋孝, 栗原勲, 小林佐紀子, 横田健一, 武田彩乃, 三石木綿子, 林毅, 城理絵, 中村俊文, 伊藤裕
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台
- Year and Date
  2013-04-25
- Data Source
  KAKENHI-PROJECT-24790953
[Presentation] 特発性アルドステロン症の病態における患者血清因子の役割2013
- Author(s)
  大山貴子, 柴田洋孝, 栗原勲, 小林佐紀子, 横田健一, 武田彩乃, 三石木綿子, 林毅, 城理絵, 中村俊文, 伊藤裕
- Organizer
  第2回臨床高血圧フォーラム
- Place of Presentation
  東京
- Year and Date
  2013-05-25
- Data Source
  KAKENHI-PROJECT-24790953

1. SHIBATA Hirotaka (20245484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 横田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kobayashi Sakiko 小林 佐紀子

KOBAYASHI Sakiko 小林 佐紀子

小林 佐紀子 コバヤシ サキコ

Research Projects

Research Products

Co-Researchers

Regulation of MR activity by a novel transcriptional coactivator, LSD1, and its significance in the development of salt-sensitive hypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

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The role of TET2 in mineralocorticoid receptor mediated transcription through epigenetic mechanisms and development of hypertensionPrincipal Investigator

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Investigation of Serum Aldosterone Inducing Factors in Patients with Idiopathic HyperaldosteronismPrincipal Investigator

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心臓におけるミネラルコルチコイド受容体(MR)作用の分子機構の検討Principal Investigator

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Regulation of aldosterone synthesis by nuclear receptor Nurr1

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[Book] Hospitalist2016

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[Book] Medical Practice2016

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[Book] HORMONE FRONTIER IN GYNECOLOGY2015

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[Journal Article] 臓器連関の実態 CKDと内分泌疾患2020

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[Journal Article] 不妊治療（生殖補助医療）希望の甲状腺機能正常者、橋本病患者2019

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[Journal Article] Epidermal growth factor receptor/extracellular signal-regulated kinase pathway enhances mineralocorticoid receptor transcriptional activity through protein stabilization2018

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[Journal Article] Intestinal Mineralocorticoid Receptor Contributes to Epithelial Sodium Channel?Mediated Intestinal Sodium Absorption and Blood Pressure Regulation2018

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[Journal Article] A case of familial dysalbuminemic hyperthyroxinemia (FDH) in Japan: FDH as a possible differential diagnosis of syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH)2017

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[Journal Article] Adrenal Insufficiency under Standard Dosage of Glucocorticoid Replacement after Unilateral Adrenalectomy for Cushing's Syndrome.2016

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Kobayashi Sakiko 小林佐紀子

KOBAYASHI Sakiko 小林佐紀子

小林佐紀子コバヤシサキコ

[Journal Article] 臓器連関の実態　CKDと内分泌疾患2020

[Presentation] 当院にて低侵襲副腎ラジオ波アブレーション治療を行った原発性アルドステロン症の年次経過　2019年報告2020