Kimura Nobuyuki 木村展之

… Alternative Names

KIMURA Nobuyuki 木村展之

木村展之キムラノブユキ

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Researcher Number	80392330
Other IDs
Affiliation (Current)	2025: 岡山理科大学, 獣医学部, 教授 2025: 国立研究開発法人国立長寿医療研究センター, 研究所研究推進基盤センター, 客員研究員 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所霊長類医科学研究センター, 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 岡山理科大学, 獣医学部, 教授 2018 – 2019: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 室長 2017: 国立研究開発法人国立長寿医療研究センター, アルツハイマー病研究部, 病因遺伝子研究室長 2015: 国立研究開発法人国立長寿医療研究センター, アルツハイマー病研究部, 室長 2015: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター・アルツハイマー病研究部・病因遺伝子研究室, 室長 … More 2013 – 2014: 独立行政法人国立長寿医療研究センター, アルツハイマー病研究部, 室長 2013: 国立長寿医療研究センター, 認知症先進医療開発センター, 室長 2012: 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 研究員 2012: 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 研究員 2011: 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 主任研究員 2007: National Institute of Biomedical Innovation, 霊長類医科学研究センター, 研究員 2006: 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 研究員 Less
Review Section/Research Field	Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Laboratory animal science / Experimental pathology Except Principal Investigator Laboratory animal science / Neurology / Nerve anatomy/Neuropathology
Keywords	Principal Investigator 老化 / アルツハイマー病 / 生体膜 / 高等霊長類モデル / 細胞外微小胞 / バイオマーカー / 疾患モデル / 神経変性疾患 / 発生工学 / 実験動物学 … More / モデルマウス開発 / 加齢性変化 / siRNA / 加齢製変化 / 膜融合輸送機能 / LGI3 / アミロイドβ … More Except Principal Investigator リン酸化 / ALS / TDP-43 / 加齢 / アルツハイマー病 / 疾患モデル動物 / 伝播 / AAVベクター / 経シナプス伝播 / 霊長類モデル / SHSY-5Y / リン酸化ニューロフィラメンド / 外側核 / サルモデル / Cystatin C / 運動ニューロン / Betz巨細胞 / 前角運動神経細胞 / サル / エクソソーム / 軸索電流 / AAV / 動物モデル / 筋萎縮性側索硬化症 / 神経変性疾患 Less

Establishment of blood-based biomarkers to reflect age-related changes in biological membranePrincipal Investigator
- Principal Investigator
  
  Kimura Nobuyuki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Okayama University of Science
Development of a new mouse model to induce Alzheimer's pathologyPrincipal Investigator
- Principal Investigator
  
  Kimura Nobuyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  National Center for Geriatrics and Gerontology
Development and analysis of new Alzheimer's disease model mice which can reproduce age-related changes in brain.
- Principal Investigator
  
  Matsuda Junichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Mechanism of transsynpatic retrograde transport in non-human primate model of ALS
- Principal Investigator
  
  OHKUBO TAKUYA
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
Development of primate model of sporadic ALS with overexpression of TDP-43
- Principal Investigator
  
  YOKOTA Takanori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Medical and Dental University
アルツハイマー主病変因子アミロイドβに対するアストログリア反応機構の検索Principal Investigator
- Principal Investigator
  
  木村展之
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  National Institute of Biomedical Innovation

[Book] Diabetes Mellitus: A risk factor for Alzheimer disease ?2019
- Author(s)
  Kimura Nobuyuki
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-17H03574
[Journal Article] Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.2024
- Author(s)
  Ueda T, Takeuchi T, Fujikake N, Suzuki M, Minakawa EN, Ueyama M, Fujino Y, Kimura N, Nagano S, Yokoseki A, Onodera O, Mochizuki H, Mizuno T, Wada K, Nagai Y.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 12 Issue: 1 Pages: 20-20
- DOI
  10.1186/s40478-024-01729-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K19762, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-21H02840
[Journal Article] Age-related alterations in protein phosphatase 2A methylation levels in brains of cynomolgus monkeys: a pilot study2023
- Author(s)
  Ando Sana、Sakurai Masashi、Shibutani Shusaku、Kimura Nobuyuki、Shimozawa Nobuhiro、Yasutomi Yasuhiro、Yabe Ryotaro、Ohama Takashi、Sato Koichi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: － Issue: 6 Pages: 1093-1093
- DOI
  10.1093/jb/mvad006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19762, KAKENHI-PROJECT-21K19395, KAKENHI-PROJECT-23K05613
[Journal Article] Cynomolgus macaque model of neuronal ceroid lipofuscinosis type 2 disease2023
- Author(s)
  Munesue Yoshiko、Ageyama Naohide、Kimura Nobuyuki、Takahashi Ichiro、Nakayama Shunya、Okabayashi Sachi、Katakai Yuko、Koie Hiroshi、Yagami Ken-ichi、Ishii Kazuhiro、Tamaoka Akira、Yasutomi Yasuhiro、Shimozawa Nobuhiro
- Journal Title
  
  Experimental Neurology
  
  Volume: 363 Pages: 114381-114381
- DOI
  10.1016/j.expneurol.2023.114381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06480, KAKENHI-PROJECT-23K05613, KAKENHI-PROJECT-22K19762
[Journal Article] Molecular dissection of ALS-linked TDP-43: involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.2020
- Author(s)
  Ishiguro A, Kimura N, Noma T, Shimo-Kon R, Ishihama A, Kon T.
- Journal Title
  
  FEBS letter
  
  Volume: - Issue: 14 Pages: 2254-2265
- DOI
  10.1002/1873-3468.13800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03574, KAKENHI-PROJECT-17H03665, KAKENHI-PROJECT-17K07291
[Journal Article] Decrease in p3‐Alcβ37 and p3‐Alcβ40, products of Alcadein β generated by γ‐secretase cleavages, in aged monkeys and patients with Alzheimer's disease2019
- Author(s)
  Hata S、Omori C、Kimura A、Saito H、Kimura N、Gupta V、Pedrini S、Hone E、Chatterjee P、Taddei K、Kasuga K、Ikeuchi T、Waragai M、Nishimura M、Hu A、Nakaya T、Meijer L、Maeda M、Yamamoto T、Masters CL、Rowe CC、Ames D、Yamamoto K、Martins RN、Gandy S、Suzuki T
- Journal Title
  
  Alzheimer's & Dementia: Translational Research & Clinical Interventions
  
  Volume: 5 Issue: 1 Pages: 740-750
- DOI
  10.1016/j.trci.2019.09.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07384, KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-19K21585, KAKENHI-PUBLICLY-18H04851, KAKENHI-PROJECT-17H03574, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-16K08237, KAKENHI-PROJECT-18H02566
[Journal Article] Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce β-Amyloid Accumulation2019
- Author(s)
  Takeuchi Shingo、Ueda Naoya、Suzuki Keiko、Shimozawa Nobuhiro、Yasutomi Yasuhiro、Kimura Nobuyuki
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 189 Issue: 2 Pages: 391-404
- DOI
  10.1016/j.ajpath.2018.10.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03574, KAKENHI-PROJECT-17H04079
[Journal Article] アルツハイマー病理の促進機序.2019
- Author(s)
  木村展之
- Journal Title
  
  月刊糖尿病
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-17H03574
[Journal Article] Traffic jam hypothesis: Relationship between endocytic dysfunction and Alzheimer's disease.2017
- Author(s)
  Kimura N, Yanagisawa K
- Journal Title
  
  Neurochem Int
  
  Volume: S0197-0186(17) Pages: 30249-8
- DOI
  10.1016/j.neuint.2017.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03574
[Journal Article] 認知症研究におけるカニクイザルの有用性2017
- Author(s)
  木村展之
- Journal Title
  
  実験医学
  
  Volume: 35(12) Pages: 135-138
- Data Source
  KAKENHI-PROJECT-17H03574
[Journal Article] TDP-43 recognizes RNA G-quadruplex structures, and controls neurite mRNA transport for local protein synthesis.2016
- Author(s)
  Ishiguro A, Kimura N, Watanabe Y, Watanabe S, Ishihama A.
- Journal Title
  
  Genes Cells
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290039
[Journal Article] Dynein Dysfunction Reproduces Age-Dependent Retromer Deficiency: Concomitant Disruption of Retrograde Trafficking Is Required for Alteration in APP Metabolism.2016
- Author(s)
  Kimura N, Samura E, Suzuki K, Okabayashi S, Shimozawa N, Yasutomi N.
- Journal Title
  
  Am J Pathol
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290039
[Journal Article] Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.2016
- Author(s)
  Ueda N, Tomita T, Yanagisawa K, Kimura N.
- Journal Title
  
  J Neurochem
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290039
[Journal Article] 脳の老年性病態に基づくアルツハイマー病（AD）の発症メカニズム.2016
- Author(s)
  木村展之
- Journal Title
  
  日本臨牀
  
  Volume: 74 Pages: 378-381
- Data Source
  KAKENHI-PROJECT-25290039
[Journal Article] Diabetes mellitus accelerates Aβ pathology in brain accompanied by enhanced GAβ generation in nonhuman primates.2015
- Author(s)
  Okabayashi S, Shimozawa N, Yasutomi Y, Yanagisawa K, Kimura N.
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 2 Pages: e0117362-e0117362
- DOI
  10.1371/journal.pone.0117362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25290039
[Journal Article] エンドサイトーシス障害とアルツハイマー病態：Traffic Jamがもたらす脳神経系への影響.2015
- Author(s)
  木村展之
- Journal Title
  
  Dementia Japan
  
  Volume: 29 Pages: 476-485
- Data Source
  KAKENHI-PROJECT-25290039
[Journal Article] A potential function for neuronal exosomes: sequestering intracerebral amyloid-beta peptide.2015
- Author(s)
  Yuyama, K., Sun, H., Usuki, S., Sakai, S., Hanamatsu, H., Mioka, T., Kimura, N., Okada, M., Tahara, H., Furukawa, J., Fujitani, N., Shinohara, Y. & Igarashi, Y.
- Journal Title
  
  FEBS letters
  
  Volume: 589 Issue: 1 Pages: 84-88
- DOI
  10.1016/j.febslet.2014.11.027
- NAID
  120005537475
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25112711, KAKENHI-PROJECT-25290039, KAKENHI-PROJECT-26290047, KAKENHI-PROJECT-26310106, KAKENHI-PROJECT-26640091, KAKENHI-PROJECT-221S0001
[Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as as amyloid beta accumulation modifier2014
- Author(s)
  Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, MA., Kimura, N., Saito, Y., Suzuki, T., Yanagida, K., Tanaka, T., Kazui, H., Kudo, T., Kodama, TS., Sato, M., Hashimoto, R., Tagami, S., Okochi, M., Ytoh, N., Nishitomi, K., Takamura, H., Katayama, T., Hashizumi, Y., Kimura, R., Kamino, K., Takeda, M
- Journal Title
  
  Proc. Acad. Natl. Sci. USA
  
  Volume: 111 Issue: 7 Pages: 2638-2643
- DOI
  10.1073/pnas.1307345111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-23791332, KAKENHI-PROJECT-24591708, KAKENHI-PROJECT-24591709, KAKENHI-PROJECT-25290039, KAKENHI-PROJECT-25293250, KAKENHI-PROJECT-25461768, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-26461746, KAKENHI-PROJECT-26461747
[Journal Article] Dynein dysfunction disrupts Aβ clearance in astrocytes via endocytic disturbances.2014
- Author(s)
  Kimura N, Okabayashi S, Ono F.
- Journal Title
  
  Neuroreport
  
  Volume: 25 Issue: 7 Pages: 514-520
- DOI
  10.1097/wnr.0000000000000124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290039
[Journal Article] Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-432012
- Author(s)
  Uchida A, Sasaguri H, Enomoto M, (18番目), et al
- Journal Title
  
  Brain
  
  Volume: 135 Issue: 3 Pages: 833-46
- DOI
  10.1093/brain/awr348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591894, KAKENHI-PROJECT-22240039, KAKENHI-PROJECT-22500325, KAKENHI-PROJECT-22890051, KAKENHI-PUBLICLY-23110505, KAKENHI-PROJECT-23591269, KAKENHI-PROJECT-23591753
[Journal Article] Sendai virus vector-mediated BDNF expression ameliorates memory deficits and synaptic degradarion in a transgenic mouse model of Alzheimer's disease2012
- Author(s)
  Iwasaki Y, Negishi T, Inoue M, Tashiro T, Tabira T, Kimura N
- Journal Title
  
  J Neurosci Res
  
  Volume: 90(5) Issue: 5 Pages: 981-989
- DOI
  10.1002/jnr.22830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240039, KAKENHI-PROJECT-23681010
[Journal Article] Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturb synaptic vesicle docking via endocytic disturbances : a potential mechanism underlying age-dependent impairment of cognitive function2012
- Author(s)
  Kimura N, Okabayashi S, Ono F
- Journal Title
  
  Am J Pathol
  
  Volume: 180(2) Issue: 2 Pages: 550-561
- DOI
  10.1016/j.ajpath.2011.10.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240039
[Journal Article] Immunohistochemical and biochemical analyses of LGI3 in monkey brain: LGI3 accumulates in aged monkey brains2007
- Author(s)
  Okabayashi S, Kimura N.
- Journal Title
  
  Cellular and Molecular Neurobiology 27(6)
  
  Pages: 819-830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790288
[Journal Article] Aβ upregulates and colocalizes with LGI3 in cultured rat astrocytes.2007
- Author(s)
  Kimura N, Ishii Y, Suzaki S, Negishi T, Kyuwa S, Yoshikawa Y.
- Journal Title
  
  Cellular and Molecular Neurobiology (In Press)
- Data Source
  KAKENHI-PROJECT-18790288
[Journal Article] Aβ upregulates and colocalizes with LGI3 in cultured rat astroc ytes2007
- Author(s)
  Kimura N, Ishii Y, Suzaki S, Negishi T, Kyuwa S, Yoshikawa Y
- Journal Title
  
  Cellular and Molecular Neurobiology 27(3)
  
  Pages: 335-350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790288
[Presentation] The relationship between endocytic disturbance and Alzheimer's disease: Findings from Zoobiquity2023
- Author(s)
  Nobuyuki Kimura
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19762
[Presentation] アルツハイマー病のZoobiquity研究：ヒトサロゲートモデルとしてのカニクイザル2022
- Author(s)
  木村展之
- Organizer
  第30回サル疾病ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-22K19762
[Presentation] 老化に伴うエンドサイトーシスの破綻とアルツハイマー病2020
- Author(s)
  木村展之.
- Organizer
  第125回日本解剖学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] Traffic Jam Hypothesis: Endocytic Disturbance & Alzheimer’s Disease Pathology.2019
- Author(s)
  Kimura N.
- Organizer
  NEURO2019（日本神経化学会、日本神経科学会合同大会）
- Invited
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] Traffic Jam仮説：老化に伴う細胞内膜輸送系の変化とアルツハイマー病態.2019
- Author(s)
  木村展之.
- Organizer
  第31回日本老年学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] Upregulation of autophagy interrupts exosome secretion to augment endocytic disturbance and enhance intracellular accumulation of Abeta.2019
- Author(s)
  Kimura N, Koinuma S, Shimozawa N, Yasutomi Y
- Organizer
  Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] オートファジーの促進はエンドサイトーシス障害を増悪して細胞内Aβの蓄積を増加する2019
- Author(s)
  木村展之, 鯉沼真吾, 下澤律浩, 保富康弘.
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] Elevated membrane cholesterol aggravates endocytic disturbance, resulting in enhanced Aβ accumulation: a potential mechanism underlying exacerbation of Aβ pathology by type 2 diabetes mellitus.2018
- Author(s)
  Kimura N, Takeuchi S, Ueda N, Suzuki K, SHimozawa N, Yasutomi Y.
- Organizer
  Society for Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] ２型糖尿病による Aβ病理増悪化機構：膜コレステロール増加とエンドサイトーシス障害.2018
- Author(s)
  木村展之, 竹内真吾, 上田直也, 鈴木恵子, 下澤律浩, 保富康弘.
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] Type 2 diabetes mellitus aggravates endocytic disturbance via elevated membrane cholesterol: mechanism underlying augmentation of age-dependent Aβ pathology.2018
- Author(s)
  Kimura N, Takeuchi S, Ueda N, Suzuki K, Shimozawa N, Yasutomi Y.
- Organizer
  第61回日本神経化学会
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] Age-Related Tau Pathology in Cynomolgus Monkey brain.2018
- Author(s)
  Kimura N, Endo K, Kondo H, Adachi E, Shimozawa N, Yasutomi Y, Uchihara T.
- Organizer
  第41回日本基礎老化学会
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] Age-related endocytic dysfunction is involved in Alzheimer’s disease pathology.2017
- Author(s)
  Kimura N
- Organizer
  第60回日本神経化学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] Dynein dysfunction impedes retromer trafficking and concomitant disruption of retrograde trafficking is required for the alteration in APP metabolism.2017
- Author(s)
  Kimura N, Samura E, Suzuki K, Okabayashi S, Shimozawa N, Yasutomi Y.
- Organizer
  Society for Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] Concomitant disruption of retrograde trafficking induces intracellular accumulation of Aβ.2017
- Author(s)
  Kimura N, Suzuki K, Tsuchiya Y
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] Dynein Dysfunction Reproduces Age-Dependent Retromer Deficiency: Concomitant Disruption of Retrograde Trafficking Alters APP Metabolism.2017
- Author(s)
  Kimura N, Samura E, Suzuki K, Okabayashi S, Shimozawa N, Yasutomi Y.
- Organizer
  ADPD2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03574
[Presentation] The perturbation of intracellular presenilin 1 transport aggravated β-amyloidogenesis in endosomes.2016
- Author(s)
  Ueda N, Tomita T, Yanagisawa K, Kimura N.
- Organizer
  第8回NAGOYAグローバルリトリート
- Place of Presentation
  大府市
- Year and Date
  2016-02-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] Type II diabetes mellitus enhances GAβ generation and accelerates Aβ pathology in nonhuman primate brain.2016
- Author(s)
  Kimura N.
- Organizer
  11th Internatinal Symposium on Geriatrics and Gerontology
- Place of Presentation
  大府市
- Year and Date
  2016-02-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] エンドサイトーシス障害とPresenilin-1：retromerとERADによる共役機構.2015
- Author(s)
  木村展之, 上田直也, 富田泰輔, 柳澤勝彦.
- Organizer
  第34回日本認知症学会
- Place of Presentation
  青森市
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] Endocytic pathology in astrocytes: dynein dysfunction disrupts Abeta clearance in astrocytes via disturbed endosome trafficking.2015
- Author(s)
  Kimura N, Okabayashi S, Ono F.
- Organizer
  第58回日本神経化学会
- Place of Presentation
  大宮市
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] 老化に伴う細胞内輸送機能の障害とアルツハイマー病態2015
- Author(s)
  木村展之
- Organizer
  BMB2015（第88回日本生化学会）
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] Ⅱ型糖尿病は老年性エンドサイトーシス障害の増悪を介してAβ病理を加速化する.2015
- Author(s)
  木村展之, 岡林佐知, 下澤律浩, 保富康宏, 柳澤勝彦
- Organizer
  第38回日本基礎老化学会
- Place of Presentation
  横浜市
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] The dysfunction of retrograde transport is sufficient to disrupt Abeta clearance in astrocytes via disturbed endosome trafficking.2015
- Author(s)
  Kimura N, Okabayashi S, Ono F.
- Organizer
  40th Congress of the Federation of the European Biochemical Societies (FEBS)
- Place of Presentation
  ベルリン
- Year and Date
  2015-07-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] アルツハイマー病におけるエンドサイトーシス障害：病態解明と創薬標的としての可能性2015
- Author(s)
  木村展之
- Organizer
  シンポジウム「アルツハイマー病先制治療薬の創出」
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2015-01-17
- Invited
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] プレセニリン1の細胞内局在におけるレトロマーの関与.2015
- Author(s)
  上田直也, 富田泰輔, 柳澤勝彦, 木村展之.
- Organizer
  BMB2015（第88回日本生化学会）
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] Traffic Jam hypothesis: endocytic dysfunction as a risk factor for Alzheimer’s disease pathology.2014
- Author(s)
  Nobuyuki Kimura
- Organizer
  第６回NAGOYAグローバルリトリート
- Place of Presentation
  愛知県大府市
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] 老化に伴う細胞内輸送機能の障害とアルツハイマー病態2014
- Author(s)
  木村展之
- Organizer
  第４７回知覚コロキウム
- Place of Presentation
  愛知県大府市
- Invited
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] Dynein Dysfunction Perturbs Intracellular Vesicle Trafficking and Synaptic Vesicle Docking via Endocytic Disturbances2013
- Author(s)
  Kimura N
- Organizer
  Alzheimer’s and Parkinson’s DiseasesADPD2013
- Place of Presentation
  フィレンツェ
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] 霊長類ALSモデルにおけるTDP-43の拡がり2013
- Author(s)
  大久保卓哉, 田尻美緒, 関口輝彦, 寺岡静香, 木村展之, 内原俊記, 水澤英洋, 横田隆徳.
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム（東京都千代田区丸の内）
- Data Source
  KAKENHI-PROJECT-24689039
[Presentation] 霊長類ALSモデルにおけるTDP-43の拡がり2013
- Author(s)
  大久保卓哉,田尻美緒,関口輝彦,寺岡静香,木村展之,内原俊記,水澤英洋,横田隆徳
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-24689039
[Presentation] Endocytic dysfunction in astrocytes of aged cynomolgus monkey brains.2013
- Author(s)
  Kimura N, Okabayashi S, Ono F.
- Organizer
  Neuro2013（第５６回日本神経化学会）
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] Retromerの加齢性局在変化とDynein機能障害との関係2013
- Author(s)
  木村展之、岡林佐知、小野文子、上田直也、下澤律浩、保富康宏、柳澤勝彦
- Organizer
  第３２回日本認知症学会
- Place of Presentation
  松本市
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] ALS霊長類モデルにおけるTDP-43の拡がりPropagation of TDP-43 in non-human primate model of ALS2012
- Author(s)
  田尻美緒,大久保卓哉,木村展之,川上ちひろ,寺岡静香,内原俊記,水澤英洋,横田隆徳
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-24689039
[Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of TDP-43.2012
- Author(s)
  Ohkubo T, Sasaguri H, Tajiri M, Kimura N、Ono F, Hirai T, Enomoto M.Uchihara T, Mizusawa H, Yokota T.
- Organizer
  Society for Neuroscience (SFN) 2012.
- Place of Presentation
  New Orleans
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-24689039
[Presentation] Propagation of TDP-43 in non-human primate model of ALS2012
- Author(s)
  Tajiri M, Ohkubo T, Kimura N, Kawakami C, Teraoka S, Uchihara T, Mizusawa H, Yokota T
- Organizer
  Society for Neuroscience 2012
- Place of Presentation
  New Orleans
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-432012
- Author(s)
  Ohkubo T, Tajiri M, Uchida A, Kimura H, Sasaguri N, Uchihara T, Mizusawa H, Yokota T
- Organizer
  2012 Annual Meeting of the American Neurological Association (ANA)
- Place of Presentation
  Boston
- Year and Date
  2012-10-08
- Data Source
  KAKENHI-PROJECT-24689039
[Presentation] TDP-43過剰発現霊長類モデルにおけるTDP-43の拡がり.2012
- Author(s)
  人矢保囃哉, 田尻美緒, 関口輝彦, 笹栗弘貴, 木村展之, 内原悛記, 水澤英洋, 横田隆徳.
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-24689039
[Presentation] Propagation of TDP-43 in non-human primate model of ALS2012
- Author(s)
  Tajiri M, Ohkubo T, Kimura N, Kawakami C, Teraoka S, Uchihara T, Mizusawa H, Yokota T
- Organizer
  Society for Neuroscience (SFN) 2012
- Place of Presentation
  New Orleans
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-24689039
[Presentation] ALS霊長類モデルにおけるTDP-43の拡がりPropagation of TDP-43 in non-human primate model of ALS2012
- Author(s)
  田尻美緒,大久保卓哉,木村展之,川上ちひろ,寺岡静香,内原俊記 ,水澤英洋,横田隆徳.
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] アストログリア細胞における加齢性エンドサイトーシス障害2012
- Author(s)
  木村展之
- Organizer
  第31回日本認知症学会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] Dynein dysfunction-mediated endocytic disturbances disrupt intracellular vesicle trafficking and synaptic vesicle docking: a potential mechanism underlying sporadic Alzheimer’s disease2012
- Author(s)
  Kimura N
- Organizer
  The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43.2012
- Author(s)
  Ohkubo T, Tajiri M, Uchida A, Kimura H, Sasaguri N, Uchihara T, Mizusawa H, Yokota T.
- Organizer
  2012 Annual Meeting of the American Neurological Association (ANA)
- Place of Presentation
  Boston
- Year and Date
  2012-10-08
- Data Source
  KAKENHI-PROJECT-24689039
[Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of TDP-432012
- Author(s)
  Ohkubo T, Sasaguri H, Tajiri M, Kimura N, Ono F, Hirai T, Enomoto M, Uchihara T, Mizusawa H, Yokota T
- Organizer
  Society for Neuroscience (SFN) 2012
- Place of Presentation
  New Orleans
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-24689039
[Presentation] TDP-43過剰発現霊長類モデルにおけるTDP-43の拡がり2012
- Author(s)
  大久保卓哉,田尻美緒,関口輝彦,笹栗弘貴,木村展之,内原俊記,水澤英洋,横田隆徳
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] Dynein dysfunction disturbs synaptic vesicle docking via abnormally enhanced endocytosis at the terminal membrane2011
- Author(s)
  木村展之、岡林佐知、小野文子
- Organizer
  第30回日本認知症学会
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] 細胞内異常局在を呈した野生型TDP-43過剰発現によるALS霊長類モデル Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011
- Author(s)
  大久保卓哉,内田あずさ,笹栗弘貴,木村展之 ,田尻美緒,久保寺隆行,内原俊記 ,水澤英洋,横田隆徳
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011
- Author(s)
  Ohkubo T, Uchida A, Sasaguri H, Kimura N, Tajiri M, Kubodera T, Uchihara T, Mizusawa H, Yokota T
- Organizer
  The 34^<th> Annual Meeting of Japan Neuroscience Society
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] 加齢がもたらすエクソソームへの影響と神経変性疾患2011
- Author(s)
  木村展之
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都府京都市
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] The truncation and phosphorylation of TDP-43 is not prerequisite for motoneuronal degeneration in non-human primate model of amyotrophic lateral sclerosis2011
- Author(s)
  Tajiri M, Sakaue F, Ohkubo T, Uchida A, Sasaguri H, Kimura N, Mizusawa H, Yokota T
- Organizer
  The 34^<th> Annual Meeting of Japan Neuroscience Society
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] 細胞内異常局在を呈した野生型TDP-43過剰発現によるALS霊長類モデルNon-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011
- Author(s)
  大久保卓哉, 内田あずさ, 笹栗弘貴, 木村展之, 田尻美緒, 久保寺隆行, 内原俊記, 水澤英洋, 横田隆徳
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] Dynein dysfunction causes the disturbance of synaptic vesicle transport and axonal swelling2011
- Author(s)
  Kimura N, Okabayashi S, Ono F
- Organizer
  Alzheimer's Association International Conference (AAIC) 2011
- Place of Presentation
  フランス・パリ
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011
- Author(s)
  Ohkubo T, Uchida A, Sasaguri H, Kimura N, Tajiri M, Kubodera T, Uchihara T, Mizusawa H, Yokota T
- Organizer
  The 34^<th> Annual Meeting of Japan Neuroscience Society
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] Aging attenuates dynactin-dynein interaction: down-regulation of dynein causes accumulation of enodogenous tau and APP in human neuroblas toma cells2007
- Author(s)
  木村展之
- Organizer
  日本認知症学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18790288
[Presentation] WIP1401 Non-Human Primate Model of Amyotrophic Lateral Sclerosis with Cytoplasmic Mislocalization of TDP-43
- Author(s)
  Ohkubo T, Tajiri M, Uchida A, Kimura N, Sasaguri N, Uchihara T, Mizusawa H, Yokota T
- Organizer
  2012Annual Meeting of the AmericanNeurological Association
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-22240039
[Presentation] Traffic Jam仮説：老年性エンドサイトーシス障害とアルツハイマー病態との関係.
- Author(s)
  木村展之
- Organizer
  第33回日本認知症学会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-29 – 2014-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] ENDOCYTIC DISTURBANCE DISRUPTS ABETA CLEARANCE IN ASTROCYTES WITHOUT AFFECTING ABETA UPTAKE.
- Author(s)
  Kimura N, Okabayashi S, Ono F.
- Organizer
  ADPD
- Place of Presentation
  Nice, France
- Year and Date
  2015-03-18 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] 糖尿病はGM1ガングリオシド結合型 Aβの産生増加を介してAβ病理を加速する.
- Author(s)
  木村展之, 岡林佐知, 下澤律浩, 保富康宏, 柳澤勝彦.
- Organizer
  第57回日本神経化学会
- Place of Presentation
  奈良県奈良市
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] DYNEIN DYSFUNCTION PERTURBS INTRACELLULAR VESICLE TRAFFICKING AND SYNAPTIC VESICLE DOCKING VIA ENDOCYTIC DISTURBANCES: A POTENTIAL MECHANISM UNDERLYING AGE-DEPENDENT COGNITIVE DYSFUNCTION.
- Author(s)
  Kimura N, Okabayashi S, Ono F.
- Organizer
  FENS 2014
- Place of Presentation
  Milan, Italy
- Year and Date
  2014-07-05 – 2014-07-09
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] Dynein dysfunction disrupts synaptic vesicle transport and docking via endocytic disturbance.
- Author(s)
  Kimura N, Okabayashi S, Ono F.
- Organizer
  第37回日本基礎老化学会
- Place of Presentation
  愛知県大府市
- Year and Date
  2014-06-26 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] The relationship between age-ependent endocytic disturbance and Presenilin-1.
- Author(s)
  Ueda N, Yanagisawa K, Kimura N.
- Organizer
  ADPD
- Place of Presentation
  Nice, France
- Year and Date
  2015-03-18 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-25290039
[Presentation] Effects of endocytic disturbance in PS1 localization and γ-secretase complex formation.
- Author(s)
  Ueda N, Yanagisawa K, Kimura N.
- Organizer
  第7回NAGOYAグローバルリトリート
- Place of Presentation
  愛知県大府市
- Year and Date
  2015-02-13 – 2015-02-14
- Data Source
  KAKENHI-PROJECT-25290039

1. UCHIHARA Toshiki (10223570)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
2. YOKOTA Takanori (90231688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. URUSHIDANI Makoto (60332326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KUWABARA Satoshi (70282481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HIGUCHI Osamu (50361720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OHKUBO TAKUYA (90587461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. Matsuda Junichiro (60181731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKAHASHI Ichiro (90171470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小木曽昇 (40638350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 下田修義 (90416173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ENOMOTO Mitsuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. HATA Saori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 鈴木利治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 石井一弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 下澤律浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 揚山直英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 田原栄俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 長野清一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kimura Nobuyuki 木村 展之

KIMURA Nobuyuki 木村 展之

木村 展之 キムラ ノブユキ

Research Projects

Research Products

Co-Researchers

Establishment of blood-based biomarkers to reflect age-related changes in biological membranePrincipal Investigator

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Review Section

Research Institution

Development of a new mouse model to induce Alzheimer's pathologyPrincipal Investigator

Principal Investigator

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Research Institution

Development and analysis of new Alzheimer's disease model mice which can reproduce age-related changes in brain.

Principal Investigator

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Mechanism of transsynpatic retrograde transport in non-human primate model of ALS

Principal Investigator

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Research Institution

Development of primate model of sporadic ALS with overexpression of TDP-43

Principal Investigator

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アルツハイマー主病変因子アミロイドβに対するアストログリア反応機構の検索Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Book] Diabetes Mellitus: A risk factor for Alzheimer disease ?2019

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Publisher

Data Source

[Journal Article] Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.2024

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DOI

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[Journal Article] Age-related alterations in protein phosphatase 2A methylation levels in brains of cynomolgus monkeys: a pilot study2023

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DOI

Data Source

[Journal Article] Cynomolgus macaque model of neuronal ceroid lipofuscinosis type 2 disease2023

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DOI

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[Journal Article] Molecular dissection of ALS-linked TDP-43: involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.2020

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[Journal Article] Decrease in p3‐Alcβ37 and p3‐Alcβ40, products of Alcadein β generated by γ‐secretase cleavages, in aged monkeys and patients with Alzheimer's disease2019

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[Journal Article] Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce β-Amyloid Accumulation2019

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[Journal Article] アルツハイマー病理の促進機序.2019

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Kimura Nobuyuki 木村展之

KIMURA Nobuyuki 木村展之

木村展之キムラノブユキ