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MARUYAMA Masahiro  丸山 将浩

ORCIDConnect your ORCID iD *help
Researcher Number 80396481
Other IDs
Affiliation (based on the past Project Information) *help 2016: 徳島大学, 大学院医歯薬学研究部(医学系), 准教授
2015: 徳島大学, 大学院医歯薬学研究部, 准教授
2008 – 2014: National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員
2007: National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員
2006: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員
2005: 東北大学, 病院, 医員
Review Section/Research Field
Principal Investigator
Psychiatric science / Neurochemistry/Neuropharmacology
Keywords
Principal Investigator
ビトロネクチン / タウオパチー / ビトロネクチン受容体 / 脳萎縮 / micro PET scan / 活性化ミクログリア / シナプス再構築 / 新生神経突起伸長 / 膜侵襲複合体 / 中枢疾患分子マーカー … More / 歯状回分子層 / オリゴデンドロサイト前駆細胞 / 神経修復機構 / 再ミエリン化 / インテグリン受容体 / 中枢神経分子マーカー / タウオパチーモデルマウス / タウモデルマウス / イメージング / 未線維化タウ病変 / 線維性封入体形成機構 / 未線維タウ構造体 / ポジトロン断層撮影 / 神経源線維変化 / 蛍光イメージング / 神経原線維変化 / 客観的予測診断法 / 軽度認知機能障害 / アルツハイマー病 / 病理学的変化を描出 / アルツハイマー病治療薬 Less
  • Research Projects

    (5 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (3 People)
  •  The exploration for key imaging molecules relating to brain accumulation of Vitronectin in the mouse model of TauopathyPrincipal Investigator

    • Principal Investigator
      MARUYAMA Masahiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      The University of Tokushima
      National Institute of Radiological Sciences
  •  An exploration for the reason about accumulation of Vitronectin in the mouse model of TauopathyPrincipal Investigator

    • Principal Investigator
      MARUYAMA masahiro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      National Institute of Radiological Sciences
  •  Development of diagnostic and therapeutic agents targeting pre- fibrillary tau lesions in Tauopathies.Principal Investigator

    • Principal Investigator
      MARUYAMA Masahiro
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Psychiatric science
    • Research Institution
      National Institute of Radiological Sciences
  •  Development of diagnostic and therapeutic agents targeting neuro fibrillary tangles in Alzheimer's disease.Principal Investigator

    • Principal Investigator
      MARUYAMA Masahiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Psychiatric science
    • Research Institution
      National Institute of Radiological Sciences
  •  アルツハイマー病の早期発見:軽度認知機能障害の臨床的病因論的多様性の検討Principal Investigator

    • Principal Investigator
      丸山 将浩
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Institute of Radiological Sciences
      Tohoku University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] タウ封入体イメージング開発におけるモデルマウス実験を通じて見えてきたもの2016

    • Author(s)
      丸山将浩、樋口真人
    • Journal Title

      日本認知症学会誌

      Volume: 30 Pages: 303-9

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461760
  • [Journal Article] Elucidation of molecular mechanism on the dementia through In vivo model animal imaging2016

    • Author(s)
      Maruyama masahiro, Makoto Higuchi
    • Journal Title

      Dementia Japan

      Volume: 30

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461760
  • [Journal Article] Visualization of tau pathology in living mouse model and human tauopathies including Alzheimer’s disease2015

    • Author(s)
      Masahiro Maruyama, Hitoshi Shimada, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
    • Journal Title

      NIRS Annual Report

      Volume: 2013-2014 Pages: 46-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461760
  • [Journal Article] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls2013

    • Author(s)
      Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M.
    • Journal Title

      Neuron

      Volume: 79 Issue: 6 Pages: 1094-1108

    • DOI

      10.1016/j.neuron.2013.07.037

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23591735, KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-25670524
  • [Journal Article] Comparison of the binding characteristics of [^<18>F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology2013

    • Author(s)
      Ryuichi Harada
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 40 Issue: 1 Pages: 125-132

    • DOI

      10.1007/s00259-012-2261-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-22390228, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23591735, KAKENHI-PROJECT-24659255, KAKENHI-PLANNED-23111009
  • [Journal Article] PET Applications in Animal Models of Neurodegenerative and Neuroinflammatory Disorders.2011

    • Author(s)
      Higuchi M, Maeda J, Ji B, Tokunaga M, Zhang MR, Maruyama M, Ono M, Fukumura T, Suhara T.
    • Journal Title

      Curr Top Behav Neurosci.

      Volume: epub ahead of print

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591735
  • [Journal Article] In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis : Insights from neuroimaging research in humans and rodent models.2010

    • Author(s)
      Higuchi M, Maeda J, Ji B, Maruyama M, Okauchi T, Tokunaga M, Ono M, Suhara T.
    • Journal Title

      Biochim Biophys Acta. 1802

      Pages: 373-388

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791158
  • [Journal Article] In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis : Insights from neuroimaging research in humans and rodent models.2010

    • Author(s)
      Higuchi M, Maeda J, Ji B, Maruyama M, Okauchi T, Tokunaga M, Ono M, Suhara T.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1802 Pages: 373-88

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791158
  • [Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease2008

    • Author(s)
      Okamura N, Funaki Y, Tashiro M, Kato M, Ishikawa Y, Maruyama M, Ishikawa H, Meguro K, Iwata R, Yanai K
    • Journal Title

      Br J Clin Pharmacol. 65(4)

      Pages: 472-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790846
  • [Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease.2008

    • Author(s)
      Okamura N, Funaki Y, Tashiro M, Kato M, Ishikawa Y, Maruyama M, Ishikawa H, Meguro K, Iwata R, Yanai K.
    • Journal Title

      Br J Clin Pharmacol. 65

      Pages: 472-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790846
  • [Journal Article] Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving2008

    • Author(s)
      Tashiro M, Sakurada Y, Mochizuki H, Horikawa E, Maruyama M, Okamura N, Watanuki S, Arai H, Itoh M, Yanai K
    • Journal Title

      Hum Psychopharmacol. 23(2)

      Pages: 139-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790846
  • [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-y1]Ethenyl)-6- (2-[Fluoro]Ethoxy)Benzoxazble : A Novel PET Agent for In Vivo Detection of Dense Amyloid Plaques in Alzheimer's Disease Patients.2007

    • Author(s)
      Kudo Y, Okamura N, Furumoto S, Tashiro M, Furukawa K, Maruyama M, Itoh M, Iwata R, Yanai K, Arai H
    • Journal Title

      J Nucl Med. 48

      Pages: 553-561

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy) benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients.2007

    • Author(s)
      Kudo Y, Okamura N, Furumoto S, Tashiro M, Furukawa K, Maruyama M, Itoh M, Iwata R, Yanai K, Arai H.
    • Journal Title

      J Nucl Med. 48

      Pages: 553-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790846
  • [Journal Article] A transient increase in cerebrospinal fluid tau level after epileptic seizure in an elderly patient.2007

    • Author(s)
      Matsui T, Maruyama M, Matsushita S, Arai H, Higuchi S, Mareyama K.
    • Journal Title

      J Am Geriatr Soc. 55

      Pages: 2096-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790846
  • [Journal Article] A transient increase in cerebrospinal fluid tau level after epileptic seizure in an elderly patient2007

    • Author(s)
      Matsui T, Maruyama M, Matsushita S, Arai H, Higuchi S, Maruyama K
    • Journal Title

      J Am Geriatr Soc. 55(12)

      Pages: 2096-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790846
  • [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients2007

    • Author(s)
      Kudo Y, Okamura N, Furumoto S, Tashiro M, Furukawa K, Maruyama M, Itoh M, Iwata R, Yanai K, Arai H
    • Journal Title

      J Nucl Med. 48(4)

      Pages: 553-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790846
  • [Journal Article] Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving.2007

    • Author(s)
      Tashiro M, Sakurada Y, Mochizuki H, Horikawa E, Maruyama M, Okamura N, Watanuki S, Arai H, Itoh M, Yanai K.
    • Journal Title

      Hum Psychopharmacol. 23

      Pages: 139-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790846
  • [Journal Article] Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography2007

    • Author(s)
      Maeda J, Ji B, Irie T, Tomiyama T, Maruyama M, Okauchi T, Staufenbiel M, Iwata N, Ono M, Saido TC, Suzuki K, Mori H, Higuchi M, Suhara T
    • Journal Title

      J Neurosci. 27(41)

      Pages: 10957-68

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790846
  • [Journal Article] ACE activity in CSF of patients with mild cognitive impairment and Alzheimer disease.2006

    • Author(s)
      He M, Ohrui T, Maruyama M, Tomita N, Nakayama K, Higuchi M, Furukawa K, Arai H
    • Journal Title

      Neurology. 67

      Pages: 1309-1310

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] A randomized trial of olfactory stimulation using black pepper oil in older people with swallowing dysfunction.2006

    • Author(s)
      Ebihara T, Ebihara S, Maruyama M, Kobayashi M, Itou A, Arai H, Sasaki H
    • Journal Title

      J Am Geriatr Soc. 54

      Pages: 1401-1406

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] Predicting human performance by channelized Hotelling observer in discriminating between Alzheimer's dementia and controls using statistically processed brain perfusion SPECT.2006

    • Author(s)
      Shidahara M, Inoue K, Maruyama MWatabe H, Taki Y, Goto R, Okada K, Kinomura S, Osawa S, Onishi Y, Ito H, Arai H, Fukuda H
    • Journal Title

      Ann Nucl Med. 20

      Pages: 605-613

    • NAID

      10031135821

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] Benefits of combining donepezil plus traditional Japanese herbal medicine on cognition and brain perfusion in Alzheimer's disease : a 12-week observer-blind, donepezil monotherapy controlled trial.2006

    • Author(s)
      Maruyama M, Tomita N, Iwasaki K, Ootsuki M, Matsui T, Nemoto M, Okamura N, Higuchi M, Tsutsui M, Suzuki T, Seki T, Kaneta T, Furukawa K, Arai H
    • Journal Title

      J Am Geriatr Soc. 54

      Pages: 869-871

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.2006

    • Author(s)
      Fujiwara H, Iwasaki K, Furukawa K, Seki T, He M, Maruyama M, Tomita N, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Ohizumi Y, Arai H
    • Journal Title

      J Neuroscience Res. 84

      Pages: 427-433

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease.2005

    • Author(s)
      Hamaguchi T, Kitamoto T, Sato T, Mizusawa H, Nakamura Y, Noguchi M, Furukawa Y, Ishida C, Kuji I, Mitani K, Murayama S, Kohriyama T, Katayama S, Yamashita M, Yamamoto T, Udaka F, Kawakami A, Ihara Y, Nishinaka T, Kuroda S, Suzuki N, Shiga Y, Arai H, Maruyama M, Yamada M.
    • Journal Title

      Neurology 57

      Pages: 832-842

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.2005

    • Author(s)
      Maruyama M, Higuchi M, Takaki Y, Matsuba Y, Tanji H, Nemoto K, Tomita N, Matsui T, Iwata N, Mizukami H, Muramatsu S, 0zawa K, Saido TC, Arai H, Sasaki H.
    • Journal Title

      Annals of Neurology 57

      Pages: 832-842

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] A randomized observer-blind controlled trial of a traditional Chinese medicine, Yi-Gan San, on behabioral and psychological symptoms and activities of daily living in dementia patients.2005

    • Author(s)
      Iwasaki K, Satoh-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Arai H, Sasaki H.
    • Journal Title

      Journal of Clinical Psychiatry 66

      Pages: 248-252

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] Quinoline and benzimidazole derivatives : candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.2005

    • Author(s)
      Okamura N, Suemoto T, Furumoto S, Suzuki M, Shimadzu H, Akatsu H, Yamamoto T, Fujiwara H, Nemoto M, Maruyama M, Arai H, Yamai K, Sawada T, Kudo Y.
    • Journal Title

      The Journal of Neuroscience 25

      Pages: 10857-10862

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] Lithium therapy and CSF biomarker levels in Alzheimer's disease.2005

    • Author(s)
      Maruyama M, Ishizawa K, Tomita N, Nemoto M, Yasuda H, Ebihara S, Ohrui T, Seki T, Iwasaki K, Okamura N, Higuchi M, Yoshida H, Kudo Y, Arai H, Sasaki H.
    • Journal Title

      Geriatrics Gerontology International 5

      Pages: 298-300

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Journal Article] Effects of the Traditional Chinese Herbal Medicine Yi-Gen San for Cholinesterase Inhibitor-Resistant Visual Hallucinations and Neuropsychiatric Symptoms in Patients With Dementia With Lewy Bodies.2005

    • Author(s)
      Iwasaki K, Maruyama M, Tomita N, Furukawa K, Nemoto M, Fujiwara H, Seki T, Fujii M, Kodama M, Arai H
    • Journal Title

      Journal of Clinical Psychiatry 66

      Pages: 1612-1613

    • Data Source
      KAKENHI-PROJECT-17700345
  • [Presentation] タウ封入体イメージング開発における モデルマウス実験を通じて見えてきたもの2015

    • Author(s)
      丸山 将浩
    • Organizer
      第34回 日本認知症学会 学術集会
    • Place of Presentation
      青森市 リンクステーションホール青森・ホテル青森
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26461760
  • [Presentation] The 2014 de Leon Prize in Neuroimaging2014

    • Author(s)
      Masahiro Maruyama, Hitoshi Shimada
    • Organizer
      Alzheimer's Imaging Consortium (AAIC)
    • Place of Presentation
      Copenhagen
    • Year and Date
      2014-07-12
    • Invited
    • Data Source
      KAKENHI-PROJECT-26461760
  • [Presentation] 接着分子ビトロネクチンによるタウ病態の制御2013

    • Author(s)
      丸山将浩
    • Organizer
      2013タウ研究ミーティング
    • Place of Presentation
      愛知
    • Year and Date
      2013-08-09
    • Data Source
      KAKENHI-PROJECT-23591735
  • [Presentation] 接着分子ビトロネクチンによるタウ病態の制御2013

    • Author(s)
      丸山 将浩
    • Organizer
      2013 タウ研究ミーティング
    • Place of Presentation
      あいち健康プラザ
    • Data Source
      KAKENHI-PROJECT-23591735
  • [Presentation] 接着性タンパクvitronectinがタウ病理と神経変性に及ぼす影響2012

    • Author(s)
      丸山 将浩
    • Organizer
      タウ研究ミーティング
    • Place of Presentation
      同志社大学
    • Data Source
      KAKENHI-PROJECT-23591735
  • [Presentation] 接着性タンパクvitronectinがタウ病理と神経変性に及ぼす影響2012

    • Author(s)
      丸山将浩
    • Organizer
      2012タウ研究ミーティング
    • Place of Presentation
      京都
    • Year and Date
      2012-06-10
    • Data Source
      KAKENHI-PROJECT-23591735
  • [Presentation] タウ封入体を標的としたタウオパチー診断薬の開発2009

    • Author(s)
      丸山将浩
    • Organizer
      第28回日本認知症学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-21791158
  • [Presentation] In-vivo optical and PET detections of fibrillar tau lesions in a mouse model of tauopathies2009

    • Author(s)
      Masahiro Maruyama
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease 2009
    • Place of Presentation
      Venna, Austria
    • Year and Date
      2009-07-11
    • Data Source
      KAKENHI-PROJECT-21791158
  • [Presentation] In-vivo optical and PET detections of fibrillar tau lesions in a mouse model of tauopathies.2009

    • Author(s)
      Maruyama M, et al.
    • Organizer
      Alzheimer's Association ICAD 2009.
    • Place of Presentation
      Vienna.
    • Year and Date
      2009-07-11
    • Data Source
      KAKENHI-PROJECT-21791158
  • [Presentation] タウ封入体を標的としたタウオパチー診断薬の開発2009

    • Author(s)
      丸山将浩
    • Organizer
      第28回日本認知症学会学術集会
    • Place of Presentation
      東北大学,仙台
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-21791158
  • 1.  須原 哲也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  樋口 真人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  前田 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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