Watanabe Nobuo 渡邊伸央

… Alternative Names

WATANABE Nobuo 渡邊伸央

渡邊伸央ワタナベノブオ

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Researcher Number	80396928
Affiliation (Current)	2025: 東海大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2023: 東海大学, 医学部, 講師 2017 – 2022: 東海大学, 医学部, 助教 2016: 東海大学, 医学部, 特定研究員 2015: 東海大学, 医学部, 奨励研究員 2011: 東京理科大学, 理工学部, 助教 … More 2011: 東京理科大学, 理工学部・応用生物科学科, 助教 2010: 東京理科大学, 東京理科大学理工学部・応用生物科学科, 助教 2009: Tokyo University of Science, 理工学部・応用生物科学科, 助教 2005: 東大, 先端科学技術研究センター Less
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Basic Section 55050:Anesthesiology-related / Anesthesiology / Bioproduction chemistry/Bioorganic chemistry / Living organism molecular science Except Principal Investigator Basic Section 59010:Rehabilitation science-related
Keywords	Principal Investigator 感染症 / 癌転移 / 動脈血栓 / 静脈血栓 / 動脈血栓症 / 静脈血栓症 / 抗体 / 感染菌 / MRSA / 多剤耐性菌 … More / クオラムセンシング / ペプチドグリカン / 抗菌活性 / 膜タンパク質 / 活性抗体 / 薬剤耐性 / モノクローナル抗体 / 炎症 / ハイスループットスクリーニング / 自己免疫疾患 / 抗原提示 / マクロファージ / 敗血症 / 活性窒素 / 活性酸素 / 変性神経疾患 / 酸化ストレス / ネオエキヌリン / 一酸化窒素 / アルカロイド / ネオエキヌリンA / 神経科学 / 抗生物質 / 老化 / 痴呆 / 薬理学 … More Except Principal Investigator 理学療法 / 神経筋電気刺激法 / ベルト電気式骨格筋電気刺激法 / DNAシ―クエンシング / プロテオミクス / ミオカイン Less

Development of novel anti-platelet agents targeting CLEC-2 and GPVI and assessment of their therapeutic targetsPrincipal Investigator
- Principal Investigator
  
  渡邊伸央
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tokai University
Study on the effectiveness of next-generation neuromuscular electrical stimulation as an alternative to physical therapy
- Principal Investigator
  
  青木弘道
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Tokai University
Establishment of antibody-cocktail therapy against invading bacteria for sepsis patientsPrincipal Investigator
- Principal Investigator
  
  Watanabe Nobuo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Tokai University
Clarification of the mechanism of functional impairment of macrophages in sepsis and development of novel therapeuticsPrincipal Investigator
- Principal Investigator
  
  WATANABE Nobuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Tokai University
Investigation of the mechanism of neuroprotection by neoechinulin APrincipal Investigator
- Principal Investigator
  
  WATANABE Nobuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tokyo University of Science
ミトコンドリア由来の活性酸素による細胞内シグナル伝達機構の解明Principal Investigator
- Principal Investigator
  
  渡邊伸央
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokyo

All 2024 2020 2019 2018 2017 2016 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Diphenyl-tetrazol-propanamide Derivatives Act as Dual-Specific Antagonists of Platelet CLEC-2 and Glycoprotein VI2024
- Author(s)
  Watanabe N, Shinozaki Y, Ogiwara S, Miyagasako R, Sasaki A, Kato J, Suzuki Y, Fukunishi N, Okada Y, Saito T, Iida Y, Higashiseto M, Masuda H, Nagata E, Gotoh K, Amino M, Tsuji T, Morita S, Nakagawa Y, Hirayama N, Inokuchi S
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 124(3) Issue: 03 Pages: 203-222
- DOI
  10.1055/a-2211-5202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07490
[Journal Article] Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells2020
- Author(s)
  Watanabe N, Kidokoro M, Tanaka M, Inoue S, Tsuji T, Akatuska H, Okada C, Iida Y, Okada Y, Suzuki Y, Sato T, Yahata T, Hirayama N, Nakagawa Y, Inokuchi S.
- Journal Title
  
  Cancer Cell International
  
  Volume: 20 Issue: 1 Pages: 263-263
- DOI
  10.1186/s12935-020-01328-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08868
[Journal Article] Usefulness of next-generation DNA sequencing for the diagnosis of urinary tract infection2020
- Author(s)
  Ishihara T, Watanabe N, Inoue S, Aoki H, Tsuji T, Yamamoto B, Yanagi H, Oki M1, Kryukov K, Nakagawa S, Inokuchi S, Ozawa H, Imanishi T
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 14 Issue: 1 Pages: 42-49
- DOI
  10.5582/ddt.2020.01000
- NAID
  130007802636
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2020-02-29
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08868
[Journal Article] Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses.2019
- Author(s)
  Tamada K, Nakajima S, Ogawa N, Inada M, Shibasaki H, Sato A, Takasawa R, Yoshimori A, Suzuki Y, Watanabe N, Oyama T, Abe H, Inoue S, Abe T, Yokomizo T, Tanuma S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 511 Issue: 3 Pages: 665-670
- DOI
  10.1016/j.bbrc.2019.01.136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08868, KAKENHI-PROJECT-18H02685, KAKENHI-PROJECT-16K08327, KAKENHI-PROJECT-19K05737, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627
[Journal Article] A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction2019
- Author(s)
  Watanabe N, Kidokoro M, Suzuki Y, Tanaka M, Inoue S, Tsukamoto H, Hirayama N, Hsieh PW, Tseng CP, Nakagawa Y, Inokuchi S
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 9 Pages: e0222331-e0222331
- DOI
  10.1371/journal.pone.0222331
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08868
[Journal Article] Detection of pathogenic bacteria in the blood from sepsis patients using 16S rRNA gene amplicon sequencing analysis.2018
- Author(s)
  Watanabe N, Kryukov K, Nakagawa S, Takeuchi JS, Takeshita M, Kirimura Y, Mitsuhashi S, Ishihara T, Aoki H, Inokuchi S, Imanishi T, Inoue S
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 8 Pages: e0202049-e0202049
- DOI
  10.1371/journal.pone.0202049
- NAID
  120006826803
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08868, KAKENHI-PROJECT-17H07123, KAKENHI-PROJECT-16J40232, KAKENHI-PROJECT-17K15708
[Journal Article] Cha-Koji, comprising green tea leaves fermented with Aspergillus luchuensis var kawachii kitahara, increases regulatory T cell production in mice and humans2018
- Author(s)
  Yamamoto Bunsei、Suzuki Yusuke、Yonezu Takahisa、Mizushima Nanami、Watanabe Nobuo、Sato Takehito、Inoue Shigeaki、Inokuchi Sadaki
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 1 Issue: 5 Pages: 1-8
- DOI
  10.1080/09168451.2018.1443789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10523
[Journal Article] A cell-based high-throughput screening assay system for inhibitor compounds of antigen presentation by HLA class II molecule2017
- Author(s)
  Watanabe Nobuo、Suzuki Yusuke、Yonezu Takahisa、Nakagawa Yuki、Shiina Takashi、Hirayama Noriaki、Inokuchi Sadaki、Inoue Shigeaki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6798-6798
- DOI
  10.1038/s41598-017-07080-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06502, KAKENHI-PROJECT-15K10523
[Journal Article] TGF-β-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche2017
- Author(s)
  Yahata Takashi、Ibrahim Abd Aziz、Muguruma Yukari、Eren Mesut、Shaffer Alexander M.、Watanabe Nobuo、Kaneko Satoko、Nakabayashi Tetsuo、Dan Takashi、Hirayama Noriaki、Vaughan Douglas E.、Miyata Toshio、Ando Kiyoshi
- Journal Title
  
  Blood
  
  Volume: 130 Issue: 21 Pages: 2283-2294
- DOI
  10.1182/blood-2017-02-767384
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-17H03572, KAKENHI-PROJECT-15K10523
[Journal Article] Nitrite administration improves sepsis-induced myocardial and mitochondrial dysfunction by modulating stress signal responses2017
- Author(s)
  Kawaguchi Ryoichi、Hirata Naoyuki、Tokinaga Yasuyuki、Hayashi Shunsuke、Inoue Shigeaki、Watanabe Nobuo、Yamakage Michiaki
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 31 Issue: 6 Pages: 885-894
- DOI
  10.1007/s00540-017-2417-0
- NAID
  40021413831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10523, KAKENHI-PROJECT-26462367
[Journal Article] Sepsis induces incomplete M2 phenotype polarization in peritoneal exudate cells in mice2016
- Author(s)
  Watanabe N, Suzuki Y, Inokuchi S, Inoue S
- Journal Title
  
  J Intensive Care
  
  Volume: 4 Issue: 1
- DOI
  10.1186/s40560-015-0124-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10523
[Journal Article] Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma2016
- Author(s)
  Liu RM, Eldridge S, Watanabe N, Deshane J, Kuo HC, Jiang C, Wang Y, Liu G, Schwiebert L, Miyata T, Thannickal VJ
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 310(4） Issue: 4 Pages: L328-L336
- DOI
  10.1152/ajplung.00217.2015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10523
[Journal Article] Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells2012
- Author(s)
  Takahashi M, Nonaka T, Hasegawa M, Watanabe N, Arai T
- Journal Title
  
  Neuroscience Letters
  
  Volume: 510 Pages: 48-52
- Data Source
  KAKENHI-PROJECT-21580131
[Journal Article] Neoechinulin A impedes the progression of rotenone-induced cytotoxicity in PC12 cells2011
- Author(s)
  Akashi S, Kimura T, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: 34 Pages: 243-248
- NAID
  130000402197
- Data Source
  KAKENHI-PROJECT-21580131
[Journal Article] S-nitrosation of cellular proteins by NO donors in rat embryonic fibroblast 3Y1 cells : factors affecting S-nitrosation2011
- Author(s)
  Ryuman N, Watanabe N, Arai T
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume: 450317
- Data Source
  KAKENHI-PROJECT-21580131
[Journal Article] Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs2010
- Author(s)
  Aoki T, Ohnishi K, Kimoto M, Fujieda S, Kuramochi K, Takeuchi T, Nakazaki A, Watanabe N, Sugawara F, Arai T, Kobayashi S
- Journal Title
  
  Pharmaceuticals
  
  Volume: 3 Pages: 1063-1069
- Data Source
  KAKENHI-PROJECT-21580131
[Journal Article] SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium2009
- Author(s)
  Konishi K, Watanabe N, Arai T
- Journal Title
  
  Nitric Oxide
  
  Volume: 4 Pages: 270-278
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Neoechinulin A confers cytoprotection against nitrosative stresses in PC12 cells while paradoxically decreasing GSH contents2011
- Author(s)
  Nakagawa T, Akashi S, Okada T, Konishi K, Ogura Y, Kuramochi K, Kobayashi S, Sugawara F, Takeuchi T, Watanabe N, Arai T
- Organizer
  5th Biannual Meeting of the Society for Free Radical Research-Asia
- Place of Presentation
  Kagoshima, Japan
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Nitric oxide induces tau protein aggregation in SY5Y cells2011
- Author(s)
  Takahashi M, Chin Y, Hasegawa M, Nonaka T, Watanabe N, Arai T
- Organizer
  5th Biannual Meeting of the Society for Free Radical Research-Asia
- Place of Presentation
  Kagoshima, Japan
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Neoechinulin A confers resistance against nitrosative stress despite inducing a significant depletion of cellular GSH2011
- Author(s)
  Watanabe N, Akashi S, Nakagawa T, Okada T, Takeuchi T, Kuramochi K, Sugawara F, Kobayashi S, Arai T
- Organizer
  18th Annual Meeting of the Society for Free Radical Biology and Medicine
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2011-12-18
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Neoechinulin A impedes cell death induced by mitochondrial complex I inhibitor rotenone2011
- Author(s)
  Akashi S, Kimura T, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T
- Organizer
  18th Annual Meeting of the Society for Free Radical Biology and Medicine
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2011-12-18
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells2011
- Author(s)
  Takahashi M, Nonaka T, Hasegawa M, Watanabe N, Arai T
- Organizer
  8th Annual Meeting of the Society for Free Radical Biology and Medicine
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2011-12-18
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] The mechanistic study of cytotoxicity induced by SIN-1 in PC12 cells2011
- Author(s)
  Okada T, Konishi K, Nakashima M, Watanabe N, Arai T
- Organizer
  5th Biannual Meeting of the Society for Free Radical Research-Asia
- Place of Presentation
  Kagoshima, Japan
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Neoechinulin A confers resistance against nitrosative stress while inducing a significant depletion of cellular GSH2011
- Author(s)
  Watanabe N, et al
- Organizer
  18th Annual Meeting of the Society for Free Radical Biology and Medicine
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium2010
- Author(s)
  Watanabe N, Konishi K, Arai T
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-06-14
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium2010
- Author(s)
  渡邊伸央
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  京都国際会議場(京都府)
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21580131
[Presentation] Nitric oxide induces tau protein oligomerization in SY5Y cells2010
- Author(s)
  Takahashi M, Chin Y, Hasegawa M, Nonaka T, Watanabe N, Arai T
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-06-14
- Data Source
  KAKENHI-PROJECT-21580131

1. 井上茂亮 (30582209)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. ARAI Takao (60107422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
3. KURAMOCHI Kouji (90408708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. KOBAYASHI Susumu (70101102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 青木弘道 (50514444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 八幡崇 (10398753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 増田治史 (50278496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. IBRAHIM Abd Aziz

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 椎名隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 安藤潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 宮田敏男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Nobuo 渡邊 伸央

WATANABE Nobuo 渡邊 伸央

渡邊 伸央 ワタナベ ノブオ

Research Projects

Research Products

Co-Researchers

Development of novel anti-platelet agents targeting CLEC-2 and GPVI and assessment of their therapeutic targetsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the effectiveness of next-generation neuromuscular electrical stimulation as an alternative to physical therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of antibody-cocktail therapy against invading bacteria for sepsis patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of the mechanism of functional impairment of macrophages in sepsis and development of novel therapeuticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanism of neuroprotection by neoechinulin APrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ミトコンドリア由来の活性酸素による細胞内シグナル伝達機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Diphenyl-tetrazol-propanamide Derivatives Act as Dual-Specific Antagonists of Platelet CLEC-2 and Glycoprotein VI2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Usefulness of next-generation DNA sequencing for the diagnosis of urinary tract infection2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of pathogenic bacteria in the blood from sepsis patients using 16S rRNA gene amplicon sequencing analysis.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Cha-Koji, comprising green tea leaves fermented with Aspergillus luchuensis var kawachii kitahara, increases regulatory T cell production in mice and humans2018

Author(s)

Journal Title

Watanabe Nobuo 渡邊伸央

WATANABE Nobuo 渡邊伸央

渡邊伸央ワタナベノブオ