UCHIDA KOICHI 内田耕一

… Alternative Names

UCHIDA Koichi 内田耕一

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Researcher Number	80397992
Affiliation (based on the past Project Information) *help	2017 – 2019: 山口県立大学, 看護栄養学部, 教授 2010 – 2013: 山口大学, 医学部附属病院, 講師 2009 – 2010: 山口大学, 医学部附属病院, 助教 2007 – 2008: Yamaguchi University, Graduate School of Medicine, Assistant Professor 2006: 山口大学, 大学院・医学系研究科, 助手 2006: 山口大学, 大学院医学系研究科, 助手 2005: 山口大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General internal medicine (including Psychosomatic medicine) / General internal medicine(including psychosomatic medicine) / Gastroenterology Except Principal Investigator Gastroenterology / Radiation science
Keywords	Principal Investigator 漢方薬 / 非アルコール性脂肪性肝炎 / 非アルコール性脂肪肝炎 / 肝線維化 / 肝硬変 / 東洋医学 / 慢性肝疾患 / CGMS / 防風通聖散 / 血糖動態 … More / 糖尿病 / 肝疾患 / 肝前癌性病変 / 肝繊維化 / 肝線維化. / 薬理学 … More Except Principal Investigator 肝細胞癌 / メダカ / 発生・分化 / 再生医学 / Development and differentiation / Cells and tissues / Cell and regenerative therapy / Regenerative medicine / 細胞・組織 / 移植・再生医療 / VEGF / ミリプラチン / 微小デンプン球 / 肝動注化学療法 / 遺伝子治療 / ABMi療法 / 肝線維化 / 修復再生療法 / Maid / 肝再生 / HTVi法 / FGF / HTVi 法 / 肝臓修復 / TNFR1 KO / Maid KO / 骨髄細胞 / 再生医療 / 薬剤スクリーニング / 高脂肪食 / NASH / IVR / HHM / TG / ゼブラフィッシュ / 癌幹細胞 / 応用動物 / 癌 Less

Verification of glycemic profiles using continuous glucose monitoring: cases with liver cirrhosis.Principal Investigator
- Principal Investigator
  
  UCHIDA KOICHI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Yamaguchi Prefectural University
The development of a novel transcatheter arterial infusion chemotherapy and significance of combination with molecular targeted agents
- Principal Investigator
  
  HIDAKA Isao
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Yamaguchi University
The basic research of the development of future generation cell therapy used bone marrow derived liver repaid cell
- Principal Investigator
  
  TERAI Shuji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamaguchi University
Both Herbal medicine Bofu-tsusho-san (TJ-62) and Dai-saiko-to (TJ-8) prevent liver fibrosis and hepatocarcinogenesis in rat liver cirrhosis.Principal Investigator
- Principal Investigator
  
  UCHIDA Kouichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Yamaguchi University
肝細胞癌に対する微小デンプン球を用いた新たな肝動脈塞栓療法の開発
- Principal Investigator
  
  山口裕樹
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Yamaguchi University
血管観察トランスジェニックメダカを用いた非アルコール性脂肪性肝炎の病態解析
- Principal Investigator
  
  坂井田功
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Yamaguchi University
The effect of Herbal medicine Bofu-tsusho-san(TJ-62)and the Crude Drugs with hepatic steatosisPrincipal Investigator
- Principal Investigator
  
  UCHIDA Koichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Yamaguchi University
癌幹細胞の発生分化制御機構の解析
- Principal Investigator
  
  SAKAIDA Isao
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Yamaguchi University
Basic studies for the development of efficient liver regenerative therapy using bone marrow cells
- Principal Investigator
  
  TERAI Shuji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamaguchi University
非アルコール性脂肪性肝炎の成因および治療の研究Principal Investigator
- Principal Investigator
  
  内田耕一
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamaguchi University

All 2019 2017 2014 2013 2012 2011 2010 2008

All Journal Article Presentation

[Journal Article] Systemic gemcitabine combined with hepatic arterial infusion chemotherapy with cisplatin, 5-fluorouracil, and isovorin for the treatment of advanced intrahepatic cholangiocarcinoma: A pilot study2014
- Author(s)
  Miho Marumoto, Takahiro Yamas,aki, Isao Hidaka, Koichi Uchida et al.
- Journal Title
  
  Hepatogastroenterology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591821
[Journal Article] Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma2014
- Author(s)
  Junichi Zaitsu, Takahiro Yamasaki, Issei Saeki, Yohei Harima, Takuya Iwamoto, Yumiko Harima, Toshihiko Matsumoto, Yohei Urata, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Naoki Yamamoto, Seiji Kaino, Koichi Uchida, Shuji Terai, Isao Sakaida
- Journal Title
  
  Hepatol Res
  
  Volume: 44 Pages: 481-490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591821
[Journal Article] Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease2013
- Author(s)
  Takashi Oono, Takahiro Yamasaki, Junichi Zaitsu, Issei Saeki, Takuya Iwamoto, Yumiko Harima, Yoshio Marumoto, Isao Hidaka, Yohei Urata, Tsuyoshi Ishikawa, Taro Takami, Makoto Segawa, Koichi Uchida, Shuji Terai, Ichiro Kunitugu, Tsuoshi Tanabe, Isao Sakaida
- Journal Title
  
  Hepatol Res
  
  Volume: (Epu ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591821
[Journal Article] Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma.2013
- Author(s)
  Zaitu J
- Journal Title
  
  Hepatol Res
  
  Volume: Apr 22 Issue: 5 Pages: 481-90
- DOI
  10.1111/hepr.12141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590978, KAKENHI-PROJECT-23591821, KAKENHI-PROJECT-24590978, KAKENHI-PROJECT-26461009
[Journal Article] Granulocyte colony-stimulating factor and interleukin-1β are important cytokines in repair of the cirrhotic liver after bone marrow cell infusion: comparison of humans and model mice2012
- Author(s)
  Mizunaga Y, Terai S, Yamamoto N, Uchida K, Yamasaki T, Nishina H, Fujita Y, Shinoda K, Hamamoto Y, Sakaida I
- Journal Title
  
  Cell Transplant
  
  Volume: 21(11) Pages: 2363-2375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390150
[Journal Article] Effect of transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma2012
- Author(s)
  Takahiro Yamasaki, Issei Saeki, Yohei Harima, Junichi Zaitsu, Masaki Maeda, Haruko Tanimoto, Takuya Iwamoto, Isao Hidaka, Yohei Urata, Tsuyoshi Ishikawa, Taro Takami, Yuhki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Sakaida
- Journal Title
  
  J Gastroenterol
  
  Volume: 47 Pages: 715-722
- NAID
  10030802839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591821
[Journal Article] Effect of transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma.2012
- Author(s)
  Takahiro Yamasaki, Isao Hidaka, Koichi Uchida et al.
- Journal Title
  
  J Gastroenterol
  
  Volume: 47 Pages: 715-722
- NAID
  10030802839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591821
[Journal Article] Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy2012
- Author(s)
  Terai S, Tanimoto H, Maeda M, Zaitsu J, Hisanaga T, Iwamoto T, Fujisawa K, Mizunaga Y, Matsumoto T, Urata Y, Marumoto Y, Hidaka I, Ishikawa T, Yokoyama Y, Aoyama K, Tsuchiya M, Takami T, Omori K, Yamamoto N, Segawa M, Uchida K, Yamasaki T, Okita K, Sakaida I
- Journal Title
  
  J Gastroenterol
  
  Volume: 47(5) Pages: 491-497
- NAID
  10030650365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390150
[Journal Article] Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients2012
- Author(s)
  Iwamoto T, Terai S, Mizunaga Y, Yamamoto N, Omori K, Uchida K, Yamasaki T, Fujii Y, Nishina H, Sakaida I
- Journal Title
  
  J Gastroenterol
  
  Volume: 47(3) Pages: 300-312
- NAID
  10030560153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390150
[Journal Article] A novel transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma : a prospective randomized trial2011
- Author(s)
  Takahiro Yamasaki, Satoe Hamabe, Issei Saeki, Yohei Harima, Yuhki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Sakaida
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 359-366
- NAID
  10029027924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591821
[Presentation] 舌所見とは何を表しているのか舌苔細菌叢の16SrRNA解析から見えてくるもの2019
- Author(s)
  瀬川誠, 山本直樹, 内田耕一, 飯塚徳男, 坂井田功
- Organizer
  第27回日本東洋医学会中四国支部山口県部会
- Data Source
  KAKENHI-PROJECT-17K09317
[Presentation] クローン病による食事の偏りが原因でNASH由来肝硬変を合併した症例2019
- Author(s)
  内田耕一、西田千尋、大村彩菜、溝口大輝、木村彩知子、森塚潤子
- Organizer
  第22回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09317
[Presentation] クローン病による食事の偏りが原因でNASH由来肝硬変を合併した症例―CGMSを用いた数年間の検討―2019
- Author(s)
  内田耕一、西田千尋、大村彩菜、溝口大輝、木村彩知子、西潤子、乃木章子、有冨早苗、山本直樹、坂井田功
- Organizer
  第２２回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09317
[Presentation] クローン病にNASH由来肝硬変合併をした一例－CGMSを用いた血糖動態の検討－2017
- Author(s)
  内田耕一、森塚潤子
- Organizer
  第10回日本静脈経腸栄養学会中国支部学術集会
- Data Source
  KAKENHI-PROJECT-17K09317
[Presentation] Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma2013
- Author(s)
  Takahiro Yamasaki, Isao Hidaka, Koichi Uchida, et al
- Organizer
  The 23rd Conference of APASL 2013
- Place of Presentation
  Suntec Singapole (Singapole)
- Data Source
  KAKENHI-PROJECT-23591821
[Presentation] Serum transferrin as apredictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma2013
- Author(s)
  Takahiro Yamasaki, Isao Hidaka, Koichi Uchida, et al
- Organizer
  The 23^<rd> Conference of APASL
- Place of Presentation
  Suntec Singapore ( Singapore )
- Data Source
  KAKENHI-PROJECT-23591821
[Presentation] Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease2013
- Author(s)
  Takahiro Yamasaki, Isao Hidaka, Koichi Uchida, et al
- Organizer
  64^<th> Annual Liver Meeting in AASLD
- Place of Presentation
  Washington Convention Center ( Washington DC, USA )
- Data Source
  KAKENHI-PROJECT-23591821
[Presentation] Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease2013
- Author(s)
  Takahiro Yamasaki, Isao Hidaka, Koichi Uchida, et al
- Organizer
  64th Annual Livr Meeting in AASLD 2013
- Place of Presentation
  Washington Convention Center (Washington DC USA)
- Data Source
  KAKENHI-PROJECT-23591821
[Presentation] Serum transferrin is an independent pre-treatment prognostic predictor for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma2012
- Author(s)
  Takahiro Yamasaki, Koichi Uchida et al.
- Organizer
  Sixth ILCA Annual Conference
- Place of Presentation
  Berlin Germany
- Data Source
  KAKENHI-PROJECT-23591821
[Presentation] 防風通聖散による NASH モデルにおける基礎的検討ならびに臨床的効果について2012
- Author(s)
  内田耕一、寺井崇二、岡本健志、橋本真一、坂井田功
- Organizer
  第33回日本肥満学会
- Place of Presentation
  京都ホテルグランビア京都
- Year and Date
  2012-10-11
- Data Source
  KAKENHI-PROJECT-22590657
[Presentation] Serum transferrin is an independent pre-treatment prognostic predictor for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma2012
- Author(s)
  Takahiro Yamasaki, Koichi Uchida, et al
- Organizer
  6^<th> ILCA Annual Conference
- Place of Presentation
  Inter Continental Berlin ( Berlin, Germany )
- Data Source
  KAKENHI-PROJECT-23591821
[Presentation] 防風通聖散によるNASHモデルにおける基礎的検討ならびに臨床的効果について2012
- Author(s)
  内田耕一
- Organizer
  第33回日本肥満学会
- Place of Presentation
  京都　ホテルグランビア京都
- Data Source
  KAKENHI-PROJECT-22590657
[Presentation] 防風通聖散はNASHに対するマクロファージ系の炎症制御効果を持つ治療薬になる2011
- Author(s)
  内田耕一
- Organizer
  第39回日本肝臓学会西部会
- Place of Presentation
  岡山コンベンションセンター、岡山県
- Year and Date
  2011-11-09
- Data Source
  KAKENHI-PROJECT-22590657
[Presentation] 肝細胞癌に対する新たな塞栓療法:リピオドール+微小デンプン球併用肝動注化学療法(Lipi+DSM-TAI)2011
- Author(s)
  山﨑隆弘、内田耕一、他
- Organizer
  第47回日本肝癌研究会
- Place of Presentation
  静岡県コンベンションアーツセンター(静岡)
- Year and Date
  2011-07-29
- Data Source
  KAKENHI-PROJECT-23591821
[Presentation] Effect of a novel transcatheter arterial infusion chemotherapy for hepatocellular carcinoma2011
- Author(s)
  Yamasaki Takahiro, Koichi Uchida, et al
- Organizer
  5^<th> ILCA Annual Conference
- Place of Presentation
  Convention and Exhibition Center ( Hong Kong, China )
- Data Source
  KAKENHI-PROJECT-23591821
[Presentation] 当科における肥満症患者に対する治療の取り組み2011
- Author(s)
  内田耕一、寺井崇二、浦田洋平、在津潤一、岡本健志、橋本真一、桑代紳哉、大石俊之、松永尚治、坂井田功
- Organizer
  第32回日本肥満学会
- Place of Presentation
  兵庫淡路夢舞台国際会議場
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22590657
[Presentation] 防風通聖散(TJ-62)は NASH に対するマクロファージ系の炎症制御効果を持つ治療薬になる2011
- Author(s)
  内田耕一、寺井崇二、坂井田功
- Organizer
  第39回日本肝臓学会西部会
- Place of Presentation
  岡山岡山コンベンションセンター
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-22590657
[Presentation] 防風通聖散・大柴胡湯によるコリン欠乏食誘発ラット肝硬変モデルにおける肝線維化抑制及び前癌性病変発生抑制効果についての検討2010
- Author(s)
  内田耕一
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形ホテルメトロポリタン山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-22590657
[Presentation] 防風通聖散・大柴胡湯によるコリン欠乏食誘発ラット肝硬変モデルにおける肝線維化抑制及び前癌性病変発生抑制効果ついての検討2010
- Author(s)
  内田耕一、山本直樹、寺井崇二、桑代紳哉、大石俊之、山崎隆弘、坂井田功
- Organizer
  第46回日本肝臓学会総
- Place of Presentation
  ホテルメトロポリタン山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-22590657
[Presentation] 漢方薬(防風通聖散・大柴胡湯)による肝脂肪化・肝線維化抑制効果について2010
- Author(s)
  内田耕一、山本直樹、桑代紳哉、大石俊之、寺井崇二、坂井田功
- Organizer
  第31回日本肥満学会
- Place of Presentation
  群馬前橋テルサ
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-22590657
[Presentation] 防風通聖散のコリン欠乏性ラット肝硬変モデルに対する肝線維化・肝発癌抑制効果についての検討2008
- Author(s)
  内田耕一、山本直樹、寺井崇二、水永裕子、岩本拓也、桑代紳哉、坂井田功
- Organizer
  第59回アメリカ肝臓病学会(AASLD)
- Place of Presentation
  米国、サンフランシスコ
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-19590693
[Presentation] 大柴胡湯のコリン欠乏性ラット肝硬変モデルに対する肝線維化・肝発癌抑制効果についての検討2008
- Author(s)
  内田耕一、山本直樹、寺井崇二、水永裕子、岩本拓也、桑代紳哉、坂井田功
- Organizer
  第59回アメリカ肝臓病学会(AASLD)
- Place of Presentation
  米国、サンフランシスコ
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-19590693

1. TERAI Syuji (00332809)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
2. SAKAIDA Isao (80263763)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
3. YAMAMOTO Naoki (90448283)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
4. YAMASAKI Takahiro (00304478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
5. IIZUKA Norio (80332807)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TAKAMI Taro (60511251)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. ISHIKAWA Tsuyoshi (20569305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. HIDAKA Isao (70593440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
9. 山口裕樹 (70379981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 森塚潤子 (10738420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

UCHIDA KOICHI 内田 耕一

UCHIDA Koichi 内田 耕一

Research Projects

Research Products

Co-Researchers

Verification of glycemic profiles using continuous glucose monitoring: cases with liver cirrhosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of a novel transcatheter arterial infusion chemotherapy and significance of combination with molecular targeted agents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The basic research of the development of future generation cell therapy used bone marrow derived liver repaid cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Both Herbal medicine Bofu-tsusho-san (TJ-62) and Dai-saiko-to (TJ-8) prevent liver fibrosis and hepatocarcinogenesis in rat liver cirrhosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝細胞癌に対する微小デンプン球を用いた新たな肝動脈塞栓療法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管観察トランスジェニックメダカを用いた非アルコール性脂肪性肝炎の病態解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of Herbal medicine Bofu-tsusho-san(TJ-62)and the Crude Drugs with hepatic steatosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

癌幹細胞の発生分化制御機構の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic studies for the development of efficient liver regenerative therapy using bone marrow cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

非アルコール性脂肪性肝炎の成因および治療の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Systemic gemcitabine combined with hepatic arterial infusion chemotherapy with cisplatin, 5-fluorouracil, and isovorin for the treatment of advanced intrahepatic cholangiocarcinoma: A pilot study2014

Author(s)

Journal Title

Data Source

[Journal Article] Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma2014

Author(s)

Journal Title

Data Source

[Journal Article] Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease2013

Author(s)

Journal Title

Data Source

[Journal Article] Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma.2013

Author(s)

Journal Title

UCHIDA KOICHI 内田耕一

UCHIDA Koichi 内田耕一

[Presentation] 舌所見とは何を表しているのか舌苔細菌叢の16SrRNA解析から見えてくるもの2019