RI SEIKA 李正花

… Alternative Names

Li Zhenghua 李正花

LI Zhenghua 李正花

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Researcher Number	80398239
Other IDs
Affiliation (Current)	2025: 熊本大学, 生命資源研究・支援センター, 客員准教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 熊本大学, 生命資源研究・支援センター, 客員准教授 2014: 熊本大学, 生命資源研究支援センター, 特任助教 2013: 熊本大学, 生命資源研究・支援センター, 助教 2012: 熊本大学, 生命資源研究支援センター, 助教 2009 – 2011: Kumamoto University, 生命資源研究・支援センター, 特定事業研究員
Review Section/Research Field	Principal Investigator Human genetics / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Laboratory animal science
Keywords	Principal Investigator 家族性アミロイドポリニューロパチー / アミロイド / 分子遺伝学 / CRSIPR/Cas9 / 遺伝子治療 / CRISPR/Cas9 / 優性遺伝病 / トランスサイレチン / CHF5074 / マウスモデル … More / 置換アレル / 相同組換え / ES細胞 / レチノール結合タンパク / レチノール / ヒト化マウス / トランスサイレチン(TTR) / レチノール結合タンパク(RBP) … More Except Principal Investigator 行動 / 可変型相同組換え / ヒト化マウス / 行動パターン / 糖尿病 / 膵炎 / 野生マウス Less

Gene therapy for FAP using TTR exon-humanized mousePrincipal Investigator
- Principal Investigator
  
  Li Zhenghua
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kumamoto University
Experimental therapy using double humanized mouse model for familial amyloidotic polyneuropathy.Principal Investigator
- Principal Investigator
  
  LI Zhenghua
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Kumamoto University
Genetic studies on unique phenotypes in MSM/Ms mouse strain
- Principal Investigator
  
  YAMAMURA Ken-ichi
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kumamoto University
Analysis pathologic processes of FAP development using double humanized micePrincipal Investigator
- Principal Investigator
  
  RI Chuhoa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Kumamoto University

All 2022 2020 2015 2014 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Dissecting pathophysiology of a human dominantly inherited disease, familial amyloidotic polyneuropathy, by using genetically engineered mice.2022
- Author(s)
  Li Z, Yamamura K.
- Journal Title
  
  Frigid Zone Med
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07354
[Journal Article] TTR exon-humanized mouse optimal for verifying new therapies for FAP2022
- Author(s)
  Li Z, Kanazashi H, Tokashiki Y, Fujikawa R, Okagaki A, Katoh S, Kojima K, Haruna K, Matsushita N, Ishikawa TO, Chen H, Yamamura K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 599 Pages: 6974-6974
- DOI
  10.1016/j.bbrc.2022.02.035
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07354
[Journal Article] CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci.2015
- Author(s)
  Mu, Yanshuang; Jin, Shoude; Shen, Jingling; Sugano, Aki; Takaoka, Yutaka; Qiang, Lixia; Imbimbo, Bruno P; Yamamura, Ken-Ichi; Li, Zhenghua
- Journal Title
  
  FEBS Letters
  
  Volume: 589 Issue: 7 Pages: 849-856
- DOI
  10.1016/j.febslet.2015.02.020
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590404, KAKENHI-PROJECT-221S0001
[Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014
- Author(s)
  Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
- Journal Title
  
  Cell Metab.
  
  Volume: 9 Issue: 4 Pages: 712-721
- DOI
  10.1016/j.cmet.2014.03.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11F01105, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-24790557, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PROJECT-25293212, KAKENHI-PROJECT-25461114, KAKENHI-PROJECT-25461361, KAKENHI-PROJECT-25870543, KAKENHI-PLANNED-26111008, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-26670207, KAKENHI-PROJECT-26670405, KAKENHI-PROJECT-26860697, KAKENHI-PROJECT-26861112
[Journal Article] Low serum level of high-sensitivity C-reactive protein in a Japanese subject with MODY32014
- Author(s)
  Ohki T, Utsu Y, Morita S, Karim M.F., Sato Y, Yoshizawa T, Yamamura K, Yamada K, Kasayama S, Yamagata K
- Journal Title
  
  J. Diabetes Invest
  
  Volume: (in press) Pages: 407-423
- DOI
  10.1016/b978-0-12-800174-5.00016-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-25293212
[Journal Article] Autophagy regulation in the pancreatic acinar cells is independent of epidermal growth factor receptor signaling.2014
- Author(s)
  Ozaki, N., Fukuchi, Y., Tomiyoshi, S., Uehara1, H., Ida, S., Wang, J., Kimi Araki, K., Sibilia, M., Baba, H., and Yamamura, K. and Ohmuraya, M.
- Journal Title
  
  Biochem. Biophysic. Res. Comm.
  
  Volume: 446 Issue: 1 Pages: 224-230
- DOI
  10.1016/j.bbrc.2014.02.111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-23310135, KAKENHI-PUBLICLY-24115712, KAKENHI-PROJECT-24591016, KAKENHI-PROJECT-25640052, KAKENHI-PROJECT-25861196, KAKENHI-PLANNED-26110003, KAKENHI-PUBLICLY-26111516, KAKENHI-PROJECT-221S0001
[Journal Article] Low serum level of high-sensitivity C-reactive protein in a Japanese subject with MODY32014
- Author(s)
  Ohki, T,, Utsu, Y., Morita, S., Karim, M.F., Sato, Y., Yoshizawa, T., Yamamura, K., Yamada, K., Kasayama, S., Yamagata, K.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010
[Journal Article] Inhibition of H3K18 deacetylation of SIRT7 by Myb-binding protein la (Mybbpla)2013
- Author(s)
  Karim Md F, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, A kaike T and Yamagata K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 441 Issue: 1 Pages: 157-163
- DOI
  10.1016/j.bbrc.2013.10.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01105, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-24790932, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PROJECT-25293212
[Journal Article] Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus2011
- Author(s)
  Zhenghua Li, Gang Zhao, Jingling Shen, Kimi Araki, Kyoko Haruna, Seiya Inoue, Jun Wang, Ken-ichi Yamamura
- Journal Title
  
  Transgenic Research
  
  Volume: Vol.20 Pages: 191-200
- URL
  http://dx.doi.org/10.1007/s11248-010-9389-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590361
[Journal Article] Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus2011
- Author(s)
  Zhenghua Li, et al
- Journal Title
  
  Transgenic Research
  
  Volume: 20 Issue: 1 Pages: 191-200
- DOI
  10.1007/s11248-010-9389-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590361
[Journal Article] Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus.2011
- Author(s)
  Li Z, et al.
- Journal Title
  
  Transgenic Research.
  
  Volume: 20 Pages: 191-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590361
[Journal Article] Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3 deficient mice and restores a normal pancreatic phenotype2010
- Author(s)
  Romac, J., M. Ohmuraya, M., C. Bittner, C., Majeed, M. F., Vigna, S. R., Que, J., Fee, B. E., Wartmann, T., Yamamura, K. and Liddle, R. A
- Journal Title
  
  Amer. J. Physiol
  
  Volume: 298 Issue: 4 Pages: G518-G524
- DOI
  10.1152/ajpgi.00431.2009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010
[Journal Article] Phenotypic characterization of anew Grin1 mutant mouse generated by ENU mutagenesis2010
- Author(s)
  Furuse T, Wada Y., Hattori K., Yamada I., Kushida T., Shibukawa Y., Masuya H., Kaneda H., Miura I.,, Seno N., Kanda K., Hirose R.,, Toki S., Nakanishi K., Kobayashi K., Sezutsu H., Gondo Y., Noda T., Yuasa S., Wakana S
- Journal Title
  
  Eur. J. Neurosci
  
  Volume: 31 Issue: 7 Pages: 1281-91
- DOI
  10.1111/j.1460-9568.2010.07164.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010
[Journal Article] Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus2010
- Author(s)
  Zhenghua Li, et al.
- Journal Title
  
  Transgenic Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590361
[Journal Article] The transthyretin gene is expressed in Schwann cells of peripheral nerves2010
- Author(s)
  Tatsufumi Murakami, Yutaka Ohsawa, Li Zhenghua, Ken-ichi Yamamura, Yoshihide Sunada
- Journal Title
  
  Brain research
  
  Volume: Vol.1248 Pages: 222-225
- URL
  http://dx.doi.org/10.1016/j.brainres.2010.06.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590361
[Journal Article] Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain2009
- Author(s)
  Araki, K., Takeda, N., Yoshiki, A., Obata, Y., Nakagata, N., Shiroishi, T., Moriwaki, K. and Yamamura, K
- Journal Title
  
  Mamm Genome
  
  Volume: 20 Issue: 1 Pages: 14-20
- DOI
  10.1007/s00335-008-9160-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010
[Presentation] エクソンヒト化による治療法開発に最適なFAPモデルマウスの開2020
- Author(s)
  李正花、金指英樹、加藤洋教、渡嘉敷佳美、藤川理恵、岡垣郁香、加藤翔、小島健太、春名享子、松下直子、熊ノ郷晴子、品川真吾、石川智夫、山村研一
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07354
[Presentation] Autophagic cell death by SPINK insufficiency induces chronic inflam-mation in the pancreas2013
- Author(s)
  Ohmuraya, M., Li, Z., Yamamura, K.
- Organizer
  The 45th Annual Meeting of the European Pancreatic Club
- Place of Presentation
  Zurich Switzerland (Kongresshaus Zurich)
- Data Source
  KAKENHI-PROJECT-21220010
[Presentation] Improvement of retinal function and vitamin A availability in humanized mice at retinol-binding protein locus2013
- Author(s)
  Li, Z., Mu, S., Shen, J., Araki, K. and Yamamura, K.
- Organizer
  第３６回日本分子生物学会
- Place of Presentation
  神戸国際会議場、神戸
- Data Source
  KAKENHI-PROJECT-24590404
[Presentation] TtrおよびRbp遺伝子座のダブルヒト化による血中ヒトTTRの増加2012
- Author(s)
  李正花
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡（マリンメッセ福岡）
- Data Source
  KAKENHI-PROJECT-24590404
[Presentation] Analysis of a novel HNF4a target gene Anks4b in pancreatic b-cells2012
- Author(s)
  Kazuya Yamagata, Yoshifumi Sato, Md. Fazlul Karim, Tatsuya Yoshizawa
- Organizer
  72^<nd> American Diabetes Association scientific sessions L
- Place of Presentation
  Hunter Limbaugh, USA (Philadelphia/Pennsylvania)
- Data Source
  KAKENHI-PROJECT-21220010
[Presentation] Production of optimum humanized mouse model for familial amyloidotic polyneuropathy2011
- Author(s)
  Zhenghua Li, Kimi Araki, Ken-ichi Yamamura
- Organizer
  Mouse genetics 2011
- Place of Presentation
  ワシントンD. C.(米国)
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-21590361
[Presentation] Production of optimum humanized mouse model for familial amyloidotic polyneuropathy2011
- Author(s)
  Li, Z.
- Organizer
  Mouse Genetics 2011
- Place of Presentation
  Washington DC・USA
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-21220010
[Presentation] 可変型相同組換え法によるTtrおよびRbp遺伝子座のダゾルヒト化マウスの作製2011
- Author(s)
  李正花, 他
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21220010
[Presentation] 可変型相同組換え法によるTtrおよびRbp遺伝子座のダブルヒト化マウスの作製2011
- Author(s)
  李正花、荒木喜美、作村由美、山村研一
- Organizer
  34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21590361
[Presentation] 可変型相同組換え法によるTtrおよびRbp遺伝子座のダブルヒト化マウスの作製2011
- Author(s)
  李正花, 等
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜,日本
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21590361
[Presentation] Production of Optimum Humanized Mouse Model for Familial Amyloidotic Polyneuropathy2011
- Author(s)
  Zhenghua Li, et al
- Organizer
  Mouse genetics 2011
- Place of Presentation
  ワシントンD.C.,米国
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-21590361
[Presentation] ヒト化マウスによる最適FAPモデルの作製2010
- Author(s)
  李正花、荒木喜美、作村由美、山村研一
- Organizer
  33回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21590361
[Presentation] Production of Optimum Humanized Mouse Model for Familial Amyloidotic Polyneuropathy2010
- Author(s)
  Li Z, et al.
- Organizer
  The 4^<th> AFLAS Congress Meeting
- Place of Presentation
  Taipei Internationtl Convention Center TICC (Taipei, Taiwan)
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-21590361
[Presentation] ヒト化マウスによる最適FAPモデルの作製2010
- Author(s)
  李正花, 他
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Data Source
  KAKENHI-PROJECT-21220010
[Presentation] ヒト化マウスによる最適FAPモデルの作製2010
- Author(s)
  李正花
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21590361
[Presentation] Production of optimum humanized mouse model for familial amyloidotic polyneuropathy2010
- Author(s)
  Zhenghua Li, Kimi Araki, Ken-ichi Yamamura
- Organizer
  The 4^<th> AFLAS Congress Meeting 5^<th> AMMRA Meeting & 11^<th> CSLAS Annual Meeting
- Place of Presentation
  台北(台湾)
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-21590361

1. YAMAMURA Ken-ichi (90115197)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. WAKANA Shigeharu (90192434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. YAMAGATA Kazuya (70324770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. YOSHINOBU Kumiko (20274730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ARAKI Kimi (90211705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. TAKEDA Naoki (90304998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. ARAKI Masatake (80271609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

RI SEIKA 李 正花

Li Zhenghua 李 正花

LI Zhenghua 李 正花

Research Projects

Research Products

Co-Researchers

Gene therapy for FAP using TTR exon-humanized mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Experimental therapy using double humanized mouse model for familial amyloidotic polyneuropathy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic studies on unique phenotypes in MSM/Ms mouse strain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis pathologic processes of FAP development using double humanized micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dissecting pathophysiology of a human dominantly inherited disease, familial amyloidotic polyneuropathy, by using genetically engineered mice.2022

Author(s)

Journal Title

Data Source

[Journal Article] TTR exon-humanized mouse optimal for verifying new therapies for FAP2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low serum level of high-sensitivity C-reactive protein in a Japanese subject with MODY32014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autophagy regulation in the pancreatic acinar cells is independent of epidermal growth factor receptor signaling.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low serum level of high-sensitivity C-reactive protein in a Japanese subject with MODY32014

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of H3K18 deacetylation of SIRT7 by Myb-binding protein la (Mybbpla)2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus2011

Author(s)

Journal Title

URL

Data Source

[Journal Article] Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus.2011

Author(s)

RI SEIKA 李正花

Li Zhenghua 李正花

LI Zhenghua 李正花