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Kawano Yutaka  河野 豊

… Alternative Names

河野 豊  カワノ ユタカ

KAWANO Yutaka  河野 豊

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Researcher Number 80398320
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-2256-0776
Affiliation (Current) 2025: 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授
Affiliation (based on the past Project Information) *help 2025: 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授
2022 – 2023: 徳島大学, 大学院医歯薬学研究部(医学域), 特任准教授
2019: 北海道医療大学, 予防医療科学センター, 准教授
2018: 北海道医療大学, 予防医療科学センター, 講師
2017: 札幌医科大学, 医学部, 研究員 … More
2012 – 2017: 札幌医科大学, 医学部, 助教
2007 – 2010: Sapporo Medical University, 医学部, 助教
2006: Sapporo Med.Univ., 4th Dept. of Int.Med., Post Doc, 医学部, 研究員
2005: 札幌医科大学, 医学部, 研究生 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Hematology / Basic Section 52010:General internal medicine-related / Tumor diagnostics
Except Principal Investigator
Hematology / Basic Section 50020:Tumor diagnostics and therapeutics-related / Gastroenterology
Keywords
Principal Investigator
BH3プロファイリング / 抗癌剤感受性 / NASH / 造血幹細胞 / hTERT / NAFLD / HNF4 alpha / MASH / MASLD / エゾウコギ … More / フィトケミカル / 脂肪肝 / 抗がん剤感受性 / BCLXL蛋白 / 5-FU耐性 / 大腸癌細胞株 / 大腸癌 / 胃がん / 全生存期間 / 胃癌 / BH3 profiling / 調節性T細胞 / 慢性移植片対宿主病 / CD4調節性T細胞 / 除鉄療法 / Hepcidin / 鉄吸収試験 / 鉄代謝 / 骨髄間質細胞 / CD133 / 末梢血 / ストローマ / CD34 / 造血幹細胞増幅 / クローン / ヒトストローマ … More
Except Principal Investigator
CXCR4 / オートファジー / 肝細胞癌 / 肝癌 / 非アルコール性脂肪肝炎 / 鉄代謝異常 / NASH / Hematopoietic stem cell / CD34 negative cell / stromal cell / cord Blood / 造血幹細胞 / CD34陰性細胞 / ストローマ / 臍帯血 / Treg / NB-UVB / GVHD Less
  • Research Projects

    (11 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (13 People)
  •  肝細胞癌に対するプラチナ系抗癌剤とオートファジー調節薬の相乗効果とその機序

    • Principal Investigator
      田中 宏典
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Tokushima
  •  フィトケミカル含有食品エゾウコギによる、新しいNAFLD/NASH治療法の開発Principal Investigator

    • Principal Investigator
      河野 豊
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      The University of Tokushima
  •  Analysis of 5-FU resistance in colon cancer using BH3 profilingPrincipal Investigator

    • Principal Investigator
      KAWANO Yutaka
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor diagnostics
    • Research Institution
      Health Sciences University of Hokkaido
      Sapporo Medical University
  •  Oxidative stress in hepatocarcinogenesis from NASH

    • Principal Investigator
      Miyanishi Koji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Prediction of drug sensitivity to gastric cancer using BH3 profilingPrincipal Investigator

    • Principal Investigator
      KAWANO YUTAKA
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Novel strategy against GVHD using NB-UVB with expansion of Treg cells

    • Principal Investigator
      Sato Tsutomu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Sapporo Medical University
  •  BH3 profiling for regulatory T cells in patients with chronic graft-versus-host disease (cGVHD)Principal Investigator

    • Principal Investigator
      KAWANO Yutaka
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Hematology
    • Research Institution
      Sapporo Medical University
  •  非アルコール性脂肪性肝炎発症における鉄代謝関連因子の分子機構解明と治療法への応用Principal Investigator

    • Principal Investigator
      河野 豊
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Analysis of peripheral blood hematopoietic stemness using human hTERT-stromal cellsPrincipal Investigator

    • Principal Investigator
      KAWANO Yutaka
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Sapporo Medical University
  •  TERT導入ストローマ・クローン細胞による効率的な造血幹細胞の体外増幅法の開発Principal Investigator

    • Principal Investigator
      河野 豊
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Ex vivo expansion of human cord blood Lin-CD34-cells using indian hedgehog stromal cells

    • Principal Investigator
      KOBUNE Masayoshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Sapporo Medical University

All 2024 2019 2016 2015 2013 2012 2009 2008 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] Acanthopanax senticosus ameliorates steatohepatitis through HNF4 alpha pathway activation in mice2024

    • Author(s)
      Kawano Yutaka、Tanaka Maki、Satoh Yasushi、Sugino Shigekazu、Suzuki Jun、Fujishima Masaki、Okumura Eri、Takekoshi Hideo、Uehara Osamu、Sugita Shintaro、Abiko Yoshihiro、Tomonari Tetsu、Tanaka Hironori、Takeda Hidekatsu、Takayama Tetsuji
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1

    • DOI

      10.1038/s41598-023-50625-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K07478
  • [Journal Article] BH3 Profiling Discriminates the Anti-apoptotic Status of 5-fluorouracil-resistant Colon Cancer Cells2019

    • Author(s)
      Kazuma Ishikawa, Yutaka Kawano, Yohei Arihara, Tomohiro Kubo, Kohichi Takada, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato
    • Journal Title

      Oncology reports

      Volume: 42 Pages: 2416-2425

    • DOI

      10.3892/or.2019.7373

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07200
  • [Journal Article] Narrow-Band Ultraviolet B Phototherapy Ameliorates Acute Graft-Versus-Host Disease of the Intestine by Expansion of Regulatory T Cells.2016

    • Author(s)
      Hashimoto A, Murase K, Kato J. et al
    • Journal Title

      PLoS One

      Volume: 31 Issue: 3 Pages: e0152823-e0152823

    • DOI

      10.1371/journal.pone.0152823

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09508, KAKENHI-PROJECT-25461429, KAKENHI-PROJECT-25461430, KAKENHI-PROJECT-26670178, KAKENHI-PROJECT-26670386
  • [Journal Article] BAK is a predictive and prognostic biomarker for the therapeutic effect of docetaxel treatment in patients with advanced gastric cancer2016

    • Author(s)
      Tomohiro Kubo, Yutaka Kawano, Nobuaki Himuro, Shintaro Sugita, Yasushi Sato, Kazuma Ishikawa, Kohichi Takada, Kazuyuki Murase, Koji Miyanishi, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Takayuki Nobuoka, Koichi Hirata, Tetsuji Takayama, Mitsuru Mori, Tadashi Hasegawa, Junji Kato
    • Journal Title

      Gastric Cancer

      Volume: 19 Issue: 3 Pages: 827-838

    • DOI

      10.1007/s10120-015-0557-1

    • NAID

      40020881713

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460943
  • [Journal Article] Increased duodenal iron absorption through upregulation of DMT1 due to enhancement of IRP1 activity in patients with NASH.2015

    • Author(s)
      Hoki T, Miyanishi K, Kato J, et al.
    • Journal Title

      Hepatology

      Volume: 印刷中 Issue: 3 Pages: 751-761

    • DOI

      10.1002/hep.27774

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591027, KAKENHI-PROJECT-24591403, KAKENHI-PROJECT-25461430, KAKENHI-PROJECT-26461037, KAKENHI-PROJECT-26670386, KAKENHI-PROJECT-15K09013, KAKENHI-PROJECT-15K09482
  • [Journal Article] Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo.2008

    • Author(s)
      Kobune M, Kato J, Kawano Y, Sasaki K, Uchida H, Takada K, Takahashi S, Takimoto R, Niitsu Y.
    • Journal Title

      Stem Cells. 6(2)

      Pages: 534-542

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790672
  • [Journal Article] Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism.2007

    • Author(s)
      Kobune M, Chiba H, Kato J, Kato K, Nakamura K, Kawano Y, Takada K, Takimoto R, Takayama T, Hamada H, Niitsu Y.
    • Journal Title

      Mol Cancer Ther. 6(6)

      Pages: 1774-1784

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790672
  • [Journal Article] Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation2007

    • Author(s)
      Junji Kato, Yutaka Kawano
    • Journal Title

      Experimental hematology (in press)

    • Data Source
      KAKENHI-PROJECT-17790457
  • [Journal Article] Ex vivo expansion of G-CSF-mobilized peripheral blood CD133+ progenitor cells on coculture with human stromal cells2006

    • Author(s)
      Kawano-Y, Kobune-M
    • Journal Title

      Experimental hematology 34(2)

      Pages: 150-158

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591003
  • [Journal Article] Ex vivo expansion of G-CSF-mobilized peripheral blood CD133+ progenitor cells on coculture with human stromal cells2006

    • Author(s)
      Yutaka Kawano
    • Journal Title

      Experimental hematology 34(2)

      Pages: 150-158

    • Data Source
      KAKENHI-PROJECT-17790457
  • [Journal Article] Ex vivo expansion of G-CSF-mobilized peripheral blood CD133+ progenitor cells on coculture with human stromal cells2006

    • Author(s)
      Yutaka Kawano, Masayoshi Kobune
    • Journal Title

      Experimental hematology 34(2)

      Pages: 150-158

    • Data Source
      KAKENHI-PROJECT-17591003
  • [Journal Article] Ex Vivo Large Scale Generation of Human Platelets From Cord Blood CD34+ Cells2006

    • Author(s)
      Takuya Matsunaga, Yutaka Kawano
    • Journal Title

      Stem Cells 24(12)

      Pages: 2877-2887

    • Data Source
      KAKENHI-PROJECT-17790457
  • [Journal Article] Ex vivo expansion of G-CSF-mobilized peripheral blood CD133+ progenitor cells on coculture with human stromal cells.2006

    • Author(s)
      Kawano-Y, Kobune-M, et al.
    • Journal Title

      Experimental hematology 34 (2)

      Pages: 150-158

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591003
  • [Journal Article] Ex vivo expansion of G-CSF-mobilized peripheral blood CD133+ progenitor cells on coculture with human stromal cells.2006

    • Author(s)
      Kawano Y, Kobune M, Chiba H, Nakamura K, Takimoto R, Takada K, Ito Y, Kato J, Hamada H, Niitsu Y.
    • Journal Title

      Exp Hematol 34(2)

      Pages: 150-158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790672
  • [Journal Article] Ex vivo expansion of G-CSF-mobilized peripheral blood CD133+ progenit or cells on coculture with human stromal cells2006

    • Author(s)
      Kawano Y, et. al.
    • Journal Title

      Exp Hematol 34

      Pages: 150-158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790672
  • [Journal Article] Ex vivo expansion of G-CSF-mobilized peripheral blood CD133+ progenitor cells on coculture with human stromal cells2006

    • Author(s)
      Yutaka Kawano, Masayoshi Kobune
    • Journal Title

      Experimental hematology 34(2)

      Pages: 150-158

    • Data Source
      KAKENHI-PROJECT-17790457
  • [Journal Article] Human mesenchymal stem cells xenografted directly to rat liver differentiated into human hepatocytes without fusion.2005

    • Author(s)
      Yasushi Sato, Yutaka Kawano
    • Journal Title

      Blood 106(2)

      Pages: 756-763

    • Data Source
      KAKENHI-PROJECT-17790457
  • [Journal Article] Mesenchymal Stem Cells That Produce Neurotrophic Factors Reduce Ischemic Damage in the Rat Middle Cerebral Artery Occlusion Model2005

    • Author(s)
      Kazuhiko Kurozumi, Yutaka Kawano
    • Journal Title

      Molecular therapy 11(1)

      Pages: 96-104

    • Data Source
      KAKENHI-PROJECT-17790457
  • [Journal Article] Telomerized human bone marrow derived cell clones maintain the phenotype of hematopoietic-supporting osteoblastic and myofibroblastic stromal cells after long-term culture.2005

    • Author(s)
      Masayoshi Kobune, Yutaka Kawano
    • Journal Title

      Experimental hematology 33(12)

      Pages: 1543-1552

    • Data Source
      KAKENHI-PROJECT-17790457
  • [Presentation] 進行胃癌におけるBH3 profilingを用いたPrecision Medicineの基礎的検討2016

    • Author(s)
      河野 豊
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-26460943
  • [Presentation] Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells2013

    • Author(s)
      村瀬和幸,河野豊,Jeremy Ryanら
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      ニューオーリンズ,アメリカ
    • Data Source
      KAKENHI-PROJECT-24890180
  • [Presentation] Low-dose-IL-2 induces Bcl2 expression and resistance to apoptosis in CD4 regulatory T cells.2013

    • Author(s)
      村瀬和幸,河野豊, Jeremy Ryan ら
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      ニューオーリンズ,アメリカ
    • Year and Date
      2013-12-09
    • Data Source
      KAKENHI-PROJECT-24890180
  • [Presentation] Differential Effects of TCR Stimulation and IL-2 On Apoptotic Pathways in CD4 Regulatory T Cells Compared to Conventional CD4 T Cells and CD8 T Cells2012

    • Author(s)
      河野 豊,村瀬和幸,Ritz Jerome
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      アトランタ,アメリカ
    • Data Source
      KAKENHI-PROJECT-24890180
  • [Presentation] 非アルコール性脂肪性肝炎における鉄蓄積機序の解析および低鉄食(鉄制限食)と瀉血併用療法の有用性について2009

    • Author(s)
      河野豊
    • Organizer
      第13回日本肝臓学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-21790676
  • 1.  KATO Junji (20244345)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 2.  Sato Tsutomu (40404602)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  Iyama Satoshi (50398319)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  KOBUNE Masayoshi (90336389)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  Miyanishi Koji (60372819)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  佐藤 康史 (80343383)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  平川 昌宏 (50561023)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  石川 和真 (30722417)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  植原 治 (00709248)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  田中 真樹 (40207139)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  田中 宏典 (40792388)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Letai Anthony
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MURASE Kazuyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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