Miyazaki Takurou 宮崎拓郎

… Alternative Names

MIYAZAKI Takuro 宮崎拓郎

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Researcher Number	80398693
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 昭和大学, 医学部, 准教授 2014 – 2018: 昭和大学, 医学部, 講師 2016: 昭和大学, 医学部生化学講座, 講師 2012 – 2014: 昭和大学, 医学部, 助教 2010: Showa University, 医学部, 助教 2008 – 2009: Showa University, 薬学部, 普通研究生
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 53020:Cardiology-related / Metabolomics / Circulatory organs internal medicine / General physiology Except Principal Investigator Basic Section 53020:Cardiology-related / Metabolomics / General medical chemistry / Neurosurgery
Keywords	Principal Investigator 動脈硬化症 / カルパイン / mRNAスプライシング / タンパク質分解 / マクロファージ / 血管内皮細胞 / 死細胞クリアランス / 肥満 / リンパ / リンパ / 制御性T細胞 … More / TGF-beta / リンパ球／制御性T細胞 / 脂質異常症 / 制御性T細胞 / リンパ管内皮細胞 / カルパイン－６ / pre-mRNAスプライシング / エクソンジャンクション複合体 / CWC22 / 飲作用 / エキソン接合部複合体 / 動脈硬化 / コレステロール / 生活習慣病 / プロテアーゼ / 網膜症 / 癌 / 血管新生 / 腹部大動脈瘤 / シェアストレス / m-カルパイン / 細胞間相互作用 / 形態形成 / 細胞運動 … More Except Principal Investigator 動脈硬化 / カルパイン / プラーク内血腫 / 冠動脈プラーク内 / CT / MRI / ハプトグロビン遺伝子多型 / プラーク内出血 / 冠動脈 / CWC22 / カルパイン６ / マクロファージ / ピノサイトーシス / アクチン / 細胞骨格 / 骨格筋 / 筋分化 / 低分子量Gタンパク質 / 炎症性サイトカイン / 移植細胞治療 / 神経細胞死 / マイクロアレイ / マイクログリア / 脳虚血 / 骨髄間葉系幹細胞 Less

プラーク内出血とハプトグロビン遺伝子多型から見た新たな冠動脈イベント予防戦略
- Principal Investigator
  
  松本英成
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Showa University
Homeostatic regulation of metabolic organs by splicing factors and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  宮崎拓郎
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Showa University
Regulation of atheroscllerosis by lymphatic endothelial calpain sysmtemsPrincipal Investigator
- Principal Investigator
  
  Miyazaki Takuro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Showa University
Targeting macrophage pinocytosis in atherosclerosisPrincipal Investigator
- Principal Investigator
  
  Miyazaki Takuro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Showa University
Functional analysis of non-proteolytic calpain to the skeletal muscle development via RhoA activity
- Principal Investigator
  
  Tonami Kazuo
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
Regulation of macrophage foam cell formation and atherosclerosis by tissue-specific calpains
- Principal Investigator
  
  MIYAZAKI AKIRA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Showa University
Repairing mechanism of human mesenchymal stem cells (hMSCs) via immune regulation on ischemia brain injury
- Principal Investigator
  
  OHTAKI HIROKAZU
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Showa University
Regulation of abdominal aortic aneurysms by calpain/calpastatin systemsPrincipal Investigator
- Principal Investigator
  
  MIYAZAKI Takuro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Showa University
Mechanisms underlying endothelial barrier functions through mechanotransductions : regulatory role of m-calpainPrincipal Investigator
- Principal Investigator
  
  MIYAZAKI Takuro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Showa University

[Book] mRNAの制御機構の解明と治療薬・ワクチンへの活用2023
- Author(s)
  宮崎拓郎　他
- Total Pages
  411
- Publisher
  技術情報協会
- ISBN
  9784861049378
- Data Source
  KAKENHI-PROJECT-23K24777
[Journal Article] Calpain and Cardiometabolic Diseases2023
- Author(s)
  Miyazaki Takuro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 23 Pages: 16782-16782
- DOI
  10.3390/ijms242316782
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24777
[Journal Article] 血管系疾患に潜むカルパインシステムの制御異常2022
- Author(s)
  宮崎拓郎, 宮崎章
- Journal Title
  
  生化学
  
  Volume: 94 Pages: 14-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08590
[Journal Article] リンパ管機能異常とアテローム性動脈硬化症2022
- Author(s)
  宮崎拓郎
- Journal Title
  
  生体の科学
  
  Volume: 73 Pages: 575-579
- Data Source
  KAKENHI-PROJECT-23K24777
[Journal Article] Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling.2022
- Author(s)
  Hayakawa S, Tamura A, Nikiforov N, Koike H, Kudo F, Cheng Y, Miyazaki T, Kubekina M, Kirichenko T, Orekhov A, Yui N, Manabe I, Oishi Y.
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 22
- DOI
  10.1172/jci.insight.138539
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19534, KAKENHI-PROJECT-21H03331, KAKENHI-PROJECT-23K21625, KAKENHI-PROJECT-23K24777, KAKENHI-PROJECT-20H03679
[Journal Article] Hypercholesterolemic Dysregulation of Calpain in Lymphatic Endothelial Cells Interferes with Regulatory T-Cell Stability and Trafficking2022
- Author(s)
  T. Miyazaki, Y. Taketomi, T. Higashi, H. Ohtaki, T. Takaki, K. Ohnishi, M. Hosonuma, N. Kono, R. Akasu, S. Haraguchi, JR. Kim-Kaneyama, K. Otsu, H. Arai, M. Murakami, A. Miyazaki
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 43 Issue: 2
- DOI
  10.1161/atvbaha.122.317781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07370, KAKENHI-PROJECT-21K19327, KAKENHI-PROJECT-22K19737, KAKENHI-PROJECT-20K17431, KAKENHI-PUBLICLY-21H00228, KAKENHI-PROJECT-22K09317, KAKENHI-PROJECT-21K08585, KAKENHI-PROJECT-20H05691, KAKENHI-PROJECT-20H03380, KAKENHI-PROJECT-23K21623, KAKENHI-PROJECT-23K24777
[Journal Article] Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis.2022
- Author(s)
  Risako Akasu, Takuro Miyazaki, Mohamed Z Elhussiny, Yuki Sugiura, Yuki Tomitsuka, Shogo Haraguchi, Kinya Otsu, Vishwajit S Chowdhury, Akira Miyazaki
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: N/A Issue: 6 Pages: 101953-101953
- DOI
  10.1016/j.jbc.2022.101953
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08590, KAKENHI-PROJECT-19K09033, KAKENHI-PROJECT-19H03110, KAKENHI-PROJECT-21K08585, KAKENHI-PROJECT-23K21623, KAKENHI-PROJECT-23K24777
[Journal Article] Hypercholesterolemia and Lymphatic Defects: The Chicken or the Egg?2021
- Author(s)
  Takuro Miyazaki, Akira Miyazaki
- Journal Title
  
  Frontiers in Cardiovascular Medicine
  
  Volume: 8 Pages: 701229-701229
- DOI
  10.3389/fcvm.2021.701229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08590, KAKENHI-PROJECT-21K08585
[Journal Article] Oral administration of L‐citrulline changes the concentrations of plasma hormones and biochemical profile in heat‐exposed broilers2021
- Author(s)
  Chowdhury Vishwajit S.、Ouchi Yoshimitsu、Han Guofeng、Eltahan Hatem M.、Haraguchi Shogo、Miyazaki Takuro、Shiraishi Jun‐ichi、Sugino Toshihisa、Bungo Takashi
- Journal Title
  
  Animal Science Journal
  
  Volume: 92 Issue: 1
- DOI
  10.1111/asj.13578
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08590, KAKENHI-PROJECT-19K09033, KAKENHI-PROJECT-20K06368, KAKENHI-PROJECT-23K21623
[Journal Article] Hic-5 is required for activation of pancreatic stellate cells and development of pancreatic fibrosis in chronic pancreatitis2020
- Author(s)
  Gao Lin、Lei Xiao-Feng、Miyauchi Aya、Noguchi Masahito、Omoto Tomokatsu、Haraguchi Shogo、Miyazaki Takuro、Miyazaki Akira、Kim-Kaneyama Joo-ri
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 19105-19105
- DOI
  10.1038/s41598-020-76095-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08404, KAKENHI-PROJECT-19K08590, KAKENHI-PROJECT-19K09033, KAKENHI-PROJECT-19K09159, KAKENHI-PROJECT-20K08525, KAKENHI-PROJECT-19H03110
[Journal Article] Calpain-Associated Proteolytic Regulation of the Stromal Microenvironment in Cancer2020
- Author(s)
  Takuro Miyazaki, Risako Akasu, Akira Miyazaki
- Journal Title
  
  Current Pharmaceutical Design
  
  Volume: N/A Issue: 28 Pages: 3128-3138
- DOI
  10.2174/1381612827666210311143053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08590, KAKENHI-PROJECT-21K08585
[Journal Article] Calpain proteolytic systems counteract endothelial cell adaptation to inflammatory environments.2020
- Author(s)
  Miyazaki T, Akasu R, Miyazaki A.
- Journal Title
  
  Inflamm Regen.
  
  Volume: 40 Issue: 1 Pages: 5-5
- DOI
  10.1186/s41232-020-00114-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08590
[Journal Article] Effects of lipid metabolism on mouse incisor dentinogenesis.2020
- Author(s)
  Kurotaki, Y., Sakai, N., Miyazaki, T., Hosonuma, M., Sato, Y., Karakawa, A., Chatani, M., Myers, M., Suzawa, T., Negishi-Koga, T., Kamijo, R., Miyazaki, A., Maruoka, Y., Takami, M.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5102-5102
- DOI
  10.1038/s41598-020-61978-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09511, KAKENHI-PROJECT-18K09866, KAKENHI-PROJECT-19K08590, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K20496, KAKENHI-PROJECT-17H04050
[Journal Article] L-Leucine increases the daily body temperature and affords thermotolerance in broiler chicks.2019
- Author(s)
  Han G, Yang H, Wang Y, Haraguchi S, Miyazaki T, Bungo T, Tashiro K, Furuse M, Chowdhury VS
- Journal Title
  
  Asian-Australas J Anim Sci
  
  Volume: in press Issue: 6 Pages: 842-848
- DOI
  10.5713/ajas.18.0677
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-19K08590, KAKENHI-PROJECT-19K09033, KAKENHI-PROJECT-18K19271
[Journal Article] Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-52019
- Author(s)
  Miyauchi Aya、Kim-Kaneyama Joo-ri、Lei Xiao-Feng、Chang Song Ho、Saito Taku、Haraguchi Shogo、Miyazaki Takuro、Miyazaki Akira
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 15770-15770
- DOI
  10.1038/s41598-019-52301-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08404, KAKENHI-PROJECT-19K08590, KAKENHI-PROJECT-19K09033, KAKENHI-PROJECT-19H03110, KAKENHI-PROJECT-17K09869, KAKENHI-PROJECT-17K10713, KAKENHI-PROJECT-17K10955, KAKENHI-PROJECT-17K10997
[Journal Article] Evaluation of protein-protein interactions using an on-membrane digestion technique2019
- Author(s)
  Obama Takashi、Miyazaki Takuro、Aiuchi Toshihiro、Miyazaki Akira、Itabe Hiroyuki
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 149 Issue: 149 Pages: 149-149
- DOI
  10.3791/59733
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069, KAKENHI-PROJECT-19K08590
[Journal Article] Evaluation of protein-protein interactions using an on-membrane digestion technique.2019
- Author(s)
  Obama T, Miyazaki T, Aiuchi T, Miyazaki A, Itabe H
- Journal Title
  
  J Vis Exp
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09418
[Journal Article] Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms2019
- Author(s)
  Haraguchi S, Kamata M, Tokita T, Tashiro KI, Sato M, Nozaki M, Okamoto-Katsuyama M, Shimizu I, Han G, Chowdhury VS, Lei XF, Miyazaki T, Kim-Kaneyama JR, Nakamachi T, Matsuda K, Ohtaki H, Tokumoto T, Tachibana T, Miyazaki A, Tsutsui K.
- Journal Title
  
  eLife
  
  Volume: 8
- DOI
  10.7554/elife.45306
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06310, KAKENHI-PROJECT-19K08404, KAKENHI-PROJECT-19K08590, KAKENHI-PROJECT-19K09033, KAKENHI-PROJECT-16H04812, KAKENHI-PROJECT-18H02473, KAKENHI-PROJECT-19H03110, KAKENHI-PROJECT-17K09869, KAKENHI-PROJECT-17K10713, KAKENHI-PROJECT-16K13054, KAKENHI-PROJECT-16H05443
[Journal Article] Endothelial calpain systems orchestrate myofibroblast differentiation during wound healing.2019
- Author(s)
  Miyazaki T, Haraguchi S, Kim-Kaneyama JR, Miyazaki A.
- Journal Title
  
  FASEB Journal
  
  Volume: 33 Issue: 2 Pages: 2037-2046
- DOI
  10.1096/fj.201800588rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09869, KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-16K10553, KAKENHI-PROJECT-19K08590
[Journal Article] Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future.2019
- Author(s)
  Shibata K, Hashimoto T, Miyazaki T, Miyazaki A, Nobe K.
- Journal Title
  
  Curr Pharm Des
  
  Volume: in press Issue: 3 Pages: 242-250
- DOI
  10.2174/1381612825666190319115018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-19K08590, KAKENHI-PROJECT-18K14958
[Journal Article] Impact of dysfunctional protein catabolism on macrophage cholesterol handling.2018
- Author(s)
  Miyazaki T, Miyazaki A.
- Journal Title
  
  Curr Med Chem.
  
  Volume: 印刷中 Issue: 9 Pages: 1631-1643
- DOI
  10.2174/0929867325666180326165234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-17K09869
[Journal Article] Dysregulation of Calpain Proteolytic Systems Underlies Degenerative Vascular Disorders2018
- Author(s)
  Miyazaki T, Miyazaki A.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 25 Issue: 1 Pages: 1-15
- DOI
  10.5551/jat.RV17008
- NAID
  130006301106
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-17K09869
[Journal Article] Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells.2018
- Author(s)
  Nozaki M, Haraguchi S, Miyazaki T, Shigeta D, Kano N, Lei XF, Kim-Kaneyama JR, Minakata H, Miyazaki A, Tsutsui K.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 2167-2167
- DOI
  10.1038/s41598-018-20226-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-17K09869, KAKENHI-PROJECT-17K10713, KAKENHI-PROJECT-16K10553
[Journal Article] The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.2018
- Author(s)
  Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.
- Journal Title
  
  Oncogene.
  
  Volume: 37 Issue: 9 Pages: 1205-1219
- DOI
  10.1038/s41388-017-0033-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-16K10553, KAKENHI-PROJECT-17K09869, KAKENHI-PROJECT-17K10713, KAKENHI-PROJECT-16K15598, KAKENHI-PROJECT-16K15625, KAKENHI-PROJECT-15K14385, KAKENHI-PROJECT-15K15611, KAKENHI-PROJECT-17H04060, KAKENHI-PROJECT-16H06267
[Journal Article] Functional Heterogeneity of Nadph Oxidases in Atherosclerotic and Aneurysmal Diseases2017
- Author(s)
  Kigawa Y, Miyazaki T, Lei XF, Kim-Kaneyama JR, Miyazaki A.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 24 Issue: 1 Pages: 1-13
- DOI
  10.5551/jat.33431
- NAID
  130005188266
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461149, KAKENHI-PROJECT-26461368, KAKENHI-PROJECT-26860588, KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-16K10553
[Journal Article] Defective protein catabolism in atherosclerotic vascular inflammation.2017
- Author(s)
  Miyazaki T, Miyazaki A.
- Journal Title
  
  Front Cardiovasc Med.
  
  Volume: 4 Pages: 79-79
- DOI
  10.3389/fcvm.2017.00079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-17K09869
[Journal Article] Emerging roles of calpain proteolytic systems in macrophage cholesterol handling.2017
- Author(s)
  Miyazaki T and Miyazaki A
- Journal Title
  
  Cellular and molecular life science
  
  Volume: 印刷中 Issue: 16 Pages: 3011-3021
- DOI
  10.1007/s00018-017-2528-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-17K09869
[Journal Article] Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice2016
- Author(s)
  Xiao-Feng Lei, Wenguang Fu, Joo-ri Kim-Kaneyama, Tomokatsu Omoto, Takuro Miyazaki, Bo Li, Akira Miyazaki
- Journal Title
  
  Journal of Hepatology
  
  Volume: 64 Issue: 1 Pages: 110-117
- DOI
  10.1016/j.jhep.2015.08.026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-26461149, KAKENHI-PROJECT-26461368, KAKENHI-PROJECT-26860588
[Journal Article] Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.2016
- Author(s)
  Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A
- Journal Title
  
  J Clin Invest
  
  Volume: 126 Issue: 9 Pages: 3417-3432
- DOI
  10.1172/jci85880
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02389, KAKENHI-PROJECT-26460454, KAKENHI-PROJECT-26461149, KAKENHI-PROJECT-26461368, KAKENHI-PROJECT-15K21367, KAKENHI-PROJECT-26860588, KAKENHI-PROJECT-15K07944, KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-16K10553, KAKENHI-PROJECT-26450172, KAKENHI-PROJECT-15H02536
[Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in adult mouse hippocampal neurogenesis after stroke.2016
- Author(s)
  Matsumoto M, Nakamachi T, Watanabe J, Sugiyama K, Ohtaki H, Murai N, Sasaki S, Xu Z, Hashimoto H, Seki T, Miyazaki A, Shioda S.
- Journal Title
  
  J Mol Neurosci
  
  Volume: 10 Issue: 2 Pages: 1007-1007
- DOI
  10.1007/s12031-016-0731-x
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10993, KAKENHI-PROJECT-25462309, KAKENHI-PROJECT-24592681, KAKENHI-PROJECT-25462236, KAKENHI-PROJECT-16H02684, KAKENHI-PROJECT-16H05443, KAKENHI-PROJECT-15K15670, KAKENHI-PROJECT-25861289, KAKENHI-PROJECT-16K13054, KAKENHI-PROJECT-16K21372
[Journal Article] Proteolytic inactivation of anti-angiogenic vasohibin-1 by cancer cells.2016
- Author(s)
  Saito M, Suzuki Y, Yano S, Miyazaki T, Sato Y.
- Journal Title
  
  Journal of biochemistry
  
  Volume: 160 Issue: 4 Pages: 227-232
- DOI
  10.1093/jb/mvw030
- NAID
  40020980740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09418
[Journal Article] Role of HIC-5 in the formation of microvilli-like structures and the monocyte-endotherial interaction that accelerates atherosclerosis2015
- Author(s)
  Shigeko Arita-Okubo, et al
- Journal Title
  
  Cardiovasc Res
  
  Volume: 105 Issue: 3 Pages: 361-371
- DOI
  10.1093/cvr/cvv003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591241, KAKENHI-PROJECT-24790784, KAKENHI-PROJECT-25293089, KAKENHI-PROJECT-26460454, KAKENHI-PROJECT-26461149, KAKENHI-PROJECT-26461368, KAKENHI-PROJECT-26860588, KAKENHI-PROJECT-15K07944, KAKENHI-PROJECT-15K09418
[Journal Article] Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.2015
- Author(s)
  Miyazaki, T., Taketomi, Y., Saito, Y., Hosono, T., Lei, X.F., Kim-Kaneyama, J.R., Arata, S., Takahashi, H., Murakami, M., and Miyazaki, A.
- Journal Title
  
  Circ. Res.
  
  Volume: 116 Issue: 7 Pages: 1170-1181
- DOI
  10.1161/circresaha.116.305363
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390021, KAKENHI-PROJECT-24790784, KAKENHI-PROJECT-25460087, KAKENHI-PROJECT-26461149, KAKENHI-PROJECT-26461368, KAKENHI-PROJECT-26860588, KAKENHI-PROJECT-15K09418, KAKENHI-PLANNED-15H05905
[Journal Article] Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms2014
- Author(s)
  Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Shigeko Arita, Stefan Offermanns, Hiroyuki Itabe, Takuro Miyazaki, Akira Miyazaki
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790784
[Journal Article] NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice.2014
- Author(s)
  Kigawa Y, Miyazaki T, Lei XF, Nakamachi T, Oguchi T, Kim-Kaneyama JR, Taniyama M, Tsunawaki S, Shioda S, Miyazaki A
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 34 Issue: 11 Pages: 2413-2420
- DOI
  10.1161/atvbaha.114.303086
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790784, KAKENHI-PROJECT-26461149, KAKENHI-PROJECT-26461368
[Journal Article] Identification of hydrogen peroxide-inducible clone 5 as a novel scaffold for the mitogen-activated protein kinase kinase 4/p54 c-Jun N-terminal kinase pathway in the development of abdominal aortic aneurysms2014
- Author(s)
  Lei XF, Kim-Kaneyama JR, Arita-Okubo S, Offermanns S, Itabe H, Miyazaki T, Miyazaki A
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 3 Issue: 3
- DOI
  10.1161/jaha.113.000747
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591341, KAKENHI-PROJECT-24791396, KAKENHI-PROJECT-26461368
[Journal Article] Identification of Hic-5 as a novel regulatory factor for integrinαIIbβ3 activation and platelet aggregation in mice2012
- Author(s)
  Kim-Kaneyama JR, Miyauchi A, Lei XF, Arita S, Mino T, Takeda N, Kou K, Eto K, Yoshida T, Miyazaki T, Shioda S, Miyazaki A
- Journal Title
  
  J Thromb Haemostat
  
  Volume: 10(9) Issue: 9 Pages: 1867-1874
- DOI
  10.1111/j.1538-7836.2012.04856.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591341, KAKENHI-PROJECT-24790784, KAKENHI-PROJECT-24791396, KAKENHI-PLANNED-23106004
[Journal Article] Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target for vascular and other disorders.2012
- Author(s)
  Kim-Kaneyama JR, Lei XF, Arita S, Miyauchi A, Miyazaki T, Miyazaki A.
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 19 Pages: 601-607
- NAID
  130004444615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790784
[Journal Article] Calpain and atherosclerosis.2012
- Author(s)
  Miyazaki T, Koya T, Kigawa Y, Oguchi T, Lei XF, Kim-Kaneyama JR, Miyazaki A.
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 20 Pages: 228-237
- NAID
  130004444661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790784
[Journal Article] Salusin-β accelerates inflammatory responses in vascular endothelial cells via NF-κB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro.2012
- Author(s)
  Koya T, Watanabe T, et al.
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 303 Issue: 1 Pages: H96-H105
- DOI
  10.1152/ajpheart.00009.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590831, KAKENHI-PROJECT-23591341, KAKENHI-PROJECT-24790784
[Journal Article] Distinct effects of tissue-type plasminogen activator and SMTP-7 on cerebrovascular inflammation following thrombolytic reperfusion2011
- Author(s)
  Miyazaki T、Kimura Y、Ohata H、Hashimoto T、Shibata K、Hasumi K、Honda K
- Journal Title
  
  Stroke 42(4)
  
  Pages: 1097-1104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790178
[Journal Article] Distinct effects of tissue-type plasminogen activator and SMTP-7 on cerebrovascular inflammation following thrombolytic reperfusion.2011
- Author(s)
  Miyazaki T., Kimura Y., Ohata H., Hashimoto T., Shibata K., Hasumi K., Honda K.
- Journal Title
  
  Stroke
  
  Volume: 42(4) Pages: 1097-1104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790178
[Journal Article] Shear stress-dependent effects of lysophosphatidic acid on agonist-induced vasomotor responses in rat mesenteric artery.2011
- Author(s)
  Shibata K., Miyazaki T., Ohata H., Honda K.
- Journal Title
  
  Journal of Cardiovascular Pharmcolology
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790178
[Journal Article] m-calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions2010
- Author(s)
  Miyazaki T、Honda K、Ohata H
- Journal Title
  
  Cardiovascular Research 85(3)
  
  Pages: 530-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790178
[Journal Article] m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions2010
- Author(s)
  Takuro Miyazaki, Kazuo Honda, Hisayuki Ohata
- Journal Title
  
  Cardiovascular Reserch 85(3)
  
  Pages: 530-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790178
[Journal Article] Shear stress-dependent effects of lysophosphatidic acid on agonist-induced vasomotor responses in rat mesenteric artery
- Author(s)
  Shibata K、Miyazaki T、Ohata H、Honda K
- Journal Title
  
  Journal of Cardiovascular Pharmacology in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790178
[Presentation] Calpain and cardiometabolic disorders2023
- Author(s)
  Takuro Miyazaki
- Organizer
  12th General Meeting of the International Proteolysis Society: Session5 Calpain and proteases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24777
[Presentation] 心血管代謝疾患に潜む細胞内タンパク質分解系の制御不全2022
- Author(s)
  宮崎拓郎
- Organizer
  心血管代謝週間CVMW2022 JVBMOシンポジウム1「炎症と疾患」
- Invited
- Data Source
  KAKENHI-PROJECT-23K24777
[Presentation] PROTEOLYTIC PRODUCTION OF FREE AMINO ACIDS BY CONVENTIONAL CALPAINS IN VASCULAR ENDOTHELIAL CELLS AUGMENTS OBESITY-INDUCED HEPATIC STEATOSIS2022
- Author(s)
  Takuro Miyazaki
- Organizer
  FASEB Science Research Conference 2022 The Biology of Calpains in Health and Disease Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24777
[Presentation] Hypercholesterolemic alterations of proteolytic systems in lymphatic endothelial cells abrogate immunosuppression in atheroprone arteries2021
- Author(s)
  Takuro Miyazaki, Risako Akasu, Akira Miyazaki
- Organizer
  19th International Symposium on Atherosclerosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] カルパインプロテアーゼシステムによる動脈硬化性疾患の制御2021
- Author(s)
  宮崎拓郎
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] Obesity-induced hepatic steatosis harbors proteolytic production of branched-chain amino acids in vascular endothelial cells2021
- Author(s)
  Risako Akasu, Takuro Miyazaki, Akira Miyazaki
- Organizer
  19th International Symposium on Atherosclerosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] リンパ管内皮細胞の細胞内プロテアーゼシステムによる動脈硬化病変の遠隔制御2021
- Author(s)
  宮崎拓郎
- Organizer
  第21回抗加齢医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] Defective exon junction complex disturbs cholesterol handling in macrophages thereby exacerbating atherosclerosis2021
- Author(s)
  Takuro Miyazaki
- Organizer
  4th International Caparica Conference in SPLICING 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] Defective exon junction complex disturbs cholesterol handling in macrophages thereby exacerbating atherosclerosis2020
- Author(s)
  Takuro Miyazaki
- Organizer
  Splicing2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] カルパインによる血管内皮細胞機能異常が耐糖能におよぼす影響2020
- Author(s)
  赤須里沙子、宮崎拓郎、冨塚祐希、宮崎章
- Organizer
  第５２回日本動脈硬化学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] 脂質異常症に起因するリンパ管内皮細胞のタンパク質恒常性低下は動脈硬化症を増悪化する2019
- Author(s)
  宮崎拓郎、原口省吾、金山朱里、宮崎章
- Organizer
  第61回日本脂質生化学会大会
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] しなやかな血管を手に入れる2019
- Author(s)
  宮崎拓郎
- Organizer
  東京都目黒区　平成31年健康大学第１回教養講座
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] リンパ管内皮細胞を起点とした動脈硬化症の発症機構2019
- Author(s)
  宮崎拓郎、原口省吾、森戸大介、金山朱里、宮崎章
- Organizer
  第51回　日本動脈硬化学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] Emerging roles of calpain-6 in macrophage cholesterol handling and atherogenesis. FASEB SRC The biology of Calpains in Health and Disease.2019
- Author(s)
  Miyazaki T
- Organizer
  FASEB SRC The biology of Calpains in Health and Disease. Session title「CALPAIN IN DIABETES AND ATHEROSCLEROSIS」
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] リンパ管のタンパク質恒常性低下を起点としたあらたな動脈硬化性血管炎の制御機構2019
- Author(s)
  宮崎拓郎
- Organizer
  第40回日本炎症・再生医学会シンポジウム２：炎症病としてのCardiovascular Diseases
- Invited
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] リンパ管のタンパク質恒常性低下を起点としたあらたな動脈硬化性血管炎の制御機構2019
- Author(s)
  宮崎拓郎
- Organizer
  第40回日本炎症・再生医学会シンポジウム２炎症病としてのCardiovascular diseases
- Invited
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] しなやかな血管を手に入れる2019
- Author(s)
  宮崎拓郎
- Organizer
  平成31年健康大学第１回教養講座
- Invited
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] 血管内皮カルパインが肥満誘発性耐糖能異常におよぼす影響2019
- Author(s)
  冨塚祐希宮崎拓郎赤須里沙子宮崎章
- Organizer
  2019年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] 血管内皮カルパインが耐糖能異常におよぼす影響2019
- Author(s)
  赤須里沙子、宮崎拓郎、冨塚祐希、宮崎章
- Organizer
  CVMW2019 心血管代謝週間
- Data Source
  KAKENHI-PROJECT-19K08590
[Presentation] マクロファージ動脈硬化原性を制御する細胞内プロテアーゼシステム.2018
- Author(s)
  宮崎拓郎
- Organizer
  第33回日本糖尿病合併症学会シンポジウム２
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] タンパク質をマスターして健康な体になろう！血管変性疾患への挑戦：しなやかな血管を手にいれる2018
- Author(s)
  宮崎拓郎
- Organizer
  東京都医学総合研究所第１回都民講座
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] Endothelial calpain systems orchestrate myofibroblast differentiation during wound healing2018
- Author(s)
  Miyazaki T, Haraguchi S, Kim-Kaneyama JR, Miyazaki A
- Organizer
  The 20th International Vascular Biology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] Regulation of atherosclerosis by calpain proteolytic systems2018
- Author(s)
  Takuro Miyazaki
- Organizer
  Spring Conference of the Korean Society of Lipid and Atherosclerosis 2018 Symposium 1: Vascular Inflammation and Remodeling
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] タンパク質恒常性低下を起点とした動脈硬化発症機構.2018
- Author(s)
  宮崎拓郎
- Organizer
  第26回日本血管生物医学会学術集会　シンポジウム2　「血管炎症機転と動脈硬化症（日本動脈硬化学会共催シンポジウム）」
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] カルパインプロテアーゼファミリーによる血管系疾患の制御.2018
- Author(s)
  宮崎拓郎・宮崎章
- Organizer
  第50回日本動脈硬化学会学術集会　合同シンポジウム2 日本血管生物医学会合同シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] 動脈硬化病変マクロファージに潜むタンパク質分解機構の制御不全2018
- Author(s)
  宮崎拓郎・宮崎章
- Organizer
  第50回日本動脈硬化学会学術集会Cutting-Edge Symposium 9 マクロファージ研究の最前線
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] 血管系疾患に潜む制御性プロテアーゼの機能不全2017
- Author(s)
  宮崎拓郎
- Organizer
  第6７回NCVC研究者交流会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] 動脈硬化病変マクロファージの飲作用を介したLDLコレステロール取込み機構2017
- Author(s)
  宮崎拓郎、雷小峰、金山朱里、宮崎章
- Organizer
  第５９回　日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] カルパインファミリーは動脈硬化病変を制御する2017
- Author(s)
  宮崎拓郎、礪波一夫、秦勝志、相内敏弘、大西紘二、雷小峰、金山朱里、竹屋元裕、板部洋之、反町洋之、栗原裕基、宮崎章
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] Disturbance of pre-mRNA splicing by calpain-6 aggravates macrophage cholesterol deposition in atherosclerotic lesions2016
- Author(s)
  宮崎拓郎
- Organizer
  第24回血管生物医学会学術集会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2016-12-09
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] カルパインー６はmRNAの成熟不全を介してマクロファージLDL取込みを促進する2016
- Author(s)
  宮崎拓郎
- Organizer
  第58回脂質生化学会大会
- Place of Presentation
  秋田市にぎわい交流館AU
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] Disturbance of pre-mRNA splicing by calpain-6 aggravates macrophage cholesterol deposition in atherosclerotic lesions.2016
- Author(s)
  Miyazaki T, Tonami K, Hata S, Aiuchi, T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A.
- Organizer
  第24回日本血管生物医学会学術集会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2016-12-09
- Invited
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] Calpain-6 potentiates pro-atherogenic pinocytosis in macrophages2016
- Author(s)
  宮崎拓郎
- Organizer
  19th International vascular biology meeting
- Place of Presentation
  Sheraton Boston Hotel (U.S.A.)
- Year and Date
  2016-11-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] カルパインによるタンパク質プロセシングと動脈硬化症2016
- Author(s)
  宮崎拓郎
- Organizer
  第４５回日本心脈管作動物質学会年会
- Place of Presentation
  阿波観光ホテル
- Year and Date
  2016-02-05
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] Disturbance of pre-mRNA splicing by calpain-6 aggravates macrophage cholesterol deposition in atherosclerotic lesions2016
- Author(s)
  Takuro Miyazaki, Kazuo Tonami, Shoji Hata, Toshihiro Aiuchi, Koji Ohnishi, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Motohiro Takeya, Hiroyuki Itabe, Hiroyuki Sorimachi, Hiroki Kurihara and Akira Miyazaki
- Organizer
  第２４回血管生物医学会学術集会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2016-12-09
- Data Source
  KAKENHI-PROJECT-15K21367
[Presentation] Calpain proteolytic systems in atherosclerotic and aneurysmal diseases2016
- Author(s)
  宮崎拓郎
- Organizer
  第48回日本動脈硬化学会学術集会
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2016-07-15
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] Calpain-6 potentiates pro-atherogenic pinocytosis in macrophages.2016
- Author(s)
  Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A.
- Organizer
  19th International vascular biology meeting
- Place of Presentation
  Sheraton Boston Hotel, Boston, 米国
- Year and Date
  2016-11-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] カルパイン-６はmRNAの成熟不全を介してマクロファージLDL取込みを促進する.2016
- Author(s)
  宮崎拓郎, 雷小峰, 金山朱里, 宮崎章
- Organizer
  第58回日本脂質生化学会大会
- Place of Presentation
  秋田市にぎわい交流館AU
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] Calpain-6 potentiates pro-atherogenic pinocytosis in macrophages2016
- Author(s)
  Takuro Miyazaki, Kazuo Tonami, Shoji Hata, Toshihiro Aiuchi, Koji Ohnishi, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Motohiro Takeya, Hiroyuki Itabe, Hiroyuki Sorimachi, Hiroki Kurihara and Akira Miyazaki
- Organizer
  19th International Vascular Biology Meeting
- Place of Presentation
  ボストン（U.S.A）
- Year and Date
  2016-11-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21367
[Presentation] カルパインシステムによる血管系疾患の制御2015
- Author(s)
  宮崎拓郎
- Organizer
  第 20 回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  ANAクラウンプラザホテルグランコート名古屋
- Year and Date
  2015-08-22
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] カルパイン－6によるマクロファージ飲作用・LDL取込ならびに動脈硬化病変の制御2015
- Author(s)
  宮崎拓郎, 雷小峰, 金山朱里, 宮崎章
- Organizer
  第57回日本脂質生化学会大会
- Place of Presentation
  一橋大学一橋講堂
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] カルパインシステムによるJAK/STAT経路依存的な病的血管新生の制御2015
- Author(s)
  宮崎拓郎、武富芳隆、雷小峰、金山朱里、村上誠、宮崎章
- Organizer
  BMB２０１５（日本分子生物学会　日本生化学会合同大会）
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] カルパインシステムによるJAK/STAT経路依存的な病的血管新生の制御2015
- Author(s)
  宮崎拓郎, 雷小峰, 金山朱里, 宮崎章
- Organizer
  第47回日本動脈硬化学会学術集会
- Place of Presentation
  仙台国際センター
- Year and Date
  2015-07-10
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] カルパインシステムによるJAK/STAT経路依存的な病的血管新生の制御2015
- Author(s)
  宮崎拓郎、雷小峰、金山朱里、宮崎章
- Organizer
  第４７回日本動脈硬化学会学術集会
- Place of Presentation
  仙台国際センター
- Year and Date
  2015-07-10
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] カルパインシステムによるJAK/STAT経路依存的な病的血管新生の制御2015
- Author(s)
  宮崎拓郎, 武富芳隆, 雷小峰, 金山朱里, 村上誠, 宮崎章
- Organizer
  BMB2015（日本分子生物学会　日本生化学会合同大会）
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] 腺におけるPituitary Adenylate Cyclase Activating Polypeptide （PACAP）の汗分泌促進効果2015
- Author(s)
  佐々木駿，渡邊潤，大滝博和，松本皆子，村井謙允，宮崎章
- Organizer
  第320回昭和大学学士会例会
- Place of Presentation
  昭和大学，東京
- Year and Date
  2015-05-27
- Data Source
  KAKENHI-PROJECT-25462236
[Presentation] Pituitary adenylate cyclase activating polypeptide (PACAP)の成体海馬神経新生・再生への関与について2015
- Author(s)
  松本皆子，渡邊潤，村井謙允，佐々木，大滝博和，宮崎章
- Organizer
  第320回昭和大学学士会例会
- Place of Presentation
  昭和大学，東京
- Year and Date
  2015-05-27
- Data Source
  KAKENHI-PROJECT-25462236
[Presentation] Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signalling 3 degradation in vascular endothelial cells2015
- Author(s)
  Takuro Miyazaki, Yoshitaka Taketomi, Yuta Saito, Tomohiko Hosono, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Satoru Arata, Haruo Takahashi, Makoto Murakami, Akira Miyazaki
- Organizer
  ISA2015 (XVII International Symposium on Atherosclerosis)
- Place of Presentation
  Amsterdam RAI
- Year and Date
  2015-05-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] カルパインシステムによる血管系疾患の制御2015
- Author(s)
  宮崎　拓郎
- Organizer
  The 16th Atherosclerosis and Biolipid Conference
- Place of Presentation
  ホテル日航東京
- Year and Date
  2015-08-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] カルパイン－6によるマクロファージ飲作用・LDL取込ならびに動脈硬化病変の制御2015
- Author(s)
  宮崎拓郎、雷小峰、金山朱里、宮崎章
- Organizer
  第５７回日本脂質生化学会大会
- Place of Presentation
  一橋大学一橋講堂
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-15K09418
[Presentation] Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells2015
- Author(s)
  Takuro Miyazaki, Yoshitaka Taketomi, Yuta Saito, Tomohiko Hosono, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Satoru Arata, Haruo Takahashi, Makoto Murakami, Akira Miyazaki
- Organizer
  XVII International Symposium on Atherosclerosis
- Place of Presentation
  アムステルダム
- Year and Date
  2015-05-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] NADPH oxidase 2 deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice through over-activation of inflammatory macrophages．2014
- Author(s)
  黄川恵慈、宮崎拓郎、宮崎章
- Organizer
  第46回日本動脈硬化学会学術集会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2014-07-11
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] VEGF-induced down-regulation of calpastatin in vascular endothelial cells confers destabilized and pro-inflammatory properties to pathological neovessels2014
- Author(s)
  Takuro Miyazaki, Yoshitaka Taketomi, Tomohiko Hosono, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Satoru Arata, Makoto Murakami, Akira Miyazaki
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  京都市勧業館みやこめっせ
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] Down-regulation of calpastatin in vascular endothelial cells confers immature and inflammatory properties to pathological neovessels．2014
- Author(s)
  宮崎拓郎、宮崎章
- Organizer
  第46回日本動脈硬化学会学術集会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2014-07-11
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] m-Calpain is induced in vascular endothelial cells on human and mouse atheromas and accelerates atherosclerotic lesion development through proteolytic disorganization of VE-cadherin2013
- Author(s)
  Takuro Miyazaki, Yoshitaka Taketomi, Masafumi Takimoto, Makoto Murakami, Akira Miyazaki
- Organizer
  2013 FASEB Summer Research Conference (SRC) Biology of Calpains in Health and Disease
- Place of Presentation
  米国　サクストンリバー
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] 血管内皮細胞におけるリゾフォスファチジルコリンによるｍ－カルパイン発現誘導とその動脈硬化症における意義2012
- Author(s)
  宮崎拓郎、雷小峰、金山朱里、宮崎章
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] Roles of calpain systems in endothelial barrier dysfunctions and atherogenesis2012
- Author(s)
  Takuro Miyazaki, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Akira Miyazaki
- Organizer
  第20回血管生物医学会学術集会
- Place of Presentation
  徳島あわぎんホール
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis2012
- Author(s)
  宮崎拓郎
- Organizer
  第４４回日本動脈硬化学会学術集会
- Place of Presentation
  ヒルトン福岡シーホーク
- Invited
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] DISTINCT EFFECTS OF TISSUE-TYPE PLASMINOGEN ACTIVATOR AND CPD-7 ON CEREBROVASCULAR INFLAMMATION DURING THROMBOLYSIS2010
- Author(s)
  Miyazaki T., Ohata H., Hasumi K., Honda K
- Organizer
  16th World Congress on Basic and Clinical Pharmacology
- Place of Presentation
  Bella Center, Copenhagen Denmark
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-20790178
[Presentation] DISTINCT EFFECTS OF TISSUE-TYPE PLASMINOGEN ACTIVATOR AND CPD-7 ON CEREBROVASCULAR INFLAMMATION DURING THROMBOLYSIS2010
- Author(s)
  Miyazaki T, Ohata H, Hasumi K, Honda K
- Organizer
  16th World Congress on Basic and Clinical Pharmacology
- Data Source
  KAKENHI-PROJECT-20790178
[Presentation] マウス中大脳動脈血栓モデルにおける改変型組織プラスミノーゲン活性化薬により誘発される血栓溶解作用と虚血・再灌流障害の評価2010
- Author(s)
  木下実季、山本翔子、宮崎拓郎、大幡久之、本田一男
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ(岡山)
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20790178
[Presentation] マウス中大脳動脈血栓モデルにおける改変型組織プラスミノーゲン活性化薬により誘発される血栓溶解作用と虚血・再灌流障害の評価2009
- Author(s)
  木下実季、山本翔子、宮崎拓郎、大幡久之、本田一男
- Organizer
  日本薬学会第130年会
- Data Source
  KAKENHI-PROJECT-20790178
[Presentation] マウス光化学刺激中大脳動脈血栓モテルにおいて組織型フラスミノケンアクチヘータによる血栓溶解時に認められる脳血管炎2009
- Author(s)
  宮崎拓郎、大幡久之、本田一男
- Organizer
  第83回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20790178
[Presentation] マウス大動脈弓におけるm-カルパイン発現が血管内皮バリア機能に及ぼす影響2008
- Author(s)
  宮崎拓郎、大幡久之、本田一男
- Organizer
  第119回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20790178
[Presentation] マウス大動脈弓におけるm-カルパイン発現が血管内皮バリア機能に及ぼす影響2008
- Author(s)
  宮崎拓郎
- Organizer
  第119回日本薬理学会関東部会
- Place of Presentation
  主婦会館プラザエフ(東京都)
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-20790178
[Presentation] NADPH oxidase 2 deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice through over-activation of inflammatory macrophages
- Author(s)
  黄川恵慈, 宮崎拓郎, 宮崎　章
- Organizer
  第46回日本動脈硬化学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] Calpain-6による動脈硬化病変およびマクロファージpinocytosisの制御
- Author(s)
  宮崎拓郎、砺波一夫、秦勝志、雷小峰、金山朱里、反町洋之、栗原裕基、宮崎章
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] VEGF-induced down-regulation of calpastatin in vascular endothelial cells confers destabilized and pro-inflammatory properties to pathological neovessels
- Author(s)
  Miyazaki T, Taketomi Y, Hosono T, Lei XF, Kim-Kaneyama JR, Arata S, Murakami M, Miyazaki A
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  京都
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] カルパインシステムによる動脈硬化性疾患の制御
- Author(s)
  宮崎拓郎
- Organizer
  第５５回東京脂質代謝研究会
- Place of Presentation
  興和株式会社東京支店
- Invited
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] Calpain-6による動脈硬化病変およびマクロファージpinocytosisの制御
- Author(s)
  宮崎拓郎、砺波一夫、秦勝志、雷小峰、金山朱里、反町洋之、栗原裕基、宮崎章
- Organizer
  第２１回日本血管生物医学会学術集会
- Place of Presentation
  千里阪急ホテル
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] Regulation of atherosclerosis by calpain and drug metabolism
- Author(s)
  Takuro Miyazaki
- Organizer
  2012 Annual Meeting of the Korean Society of Applied Pharmacology
- Place of Presentation
  Kangwon National University, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] Identification of Hic-5 as a novel regulatory factor for integrin αIIbβ3 activation and platelet aggregation in mice
- Author(s)
  Kim-Kaneyama JR, Miyauchi A, Lei XF, Arita S, Eto K, Miyazaki T, Miyazaki A
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  京都
- Year and Date
  2014-04-11 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] Identification of Hic-5 as a novel scaffold for the MKK4/JNK2 pathway in the development of abdominal aortic aneurysms
- Author(s)
  Lei XF, Kim-Kaneyama JR, Arita S, Offermanns S, Miyazaki T, Miyazaki A
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  京都
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] Salusin-βによる動脈硬化性血管炎の制御
- Author(s)
  宮崎拓郎
- Organizer
  第２回サリューシン研究会
- Place of Presentation
  小田急センチュリー相模大野
- Invited
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] カルパインシステムによる動脈硬化性疾患の制御
- Author(s)
  宮崎拓郎
- Organizer
  第14回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  長井記念ホール
- Invited
- Data Source
  KAKENHI-PROJECT-24790784
[Presentation] Down-regulation of calpastatin in vascular endothelial cells confers immature and inflammatory properties to pathological neovessels
- Author(s)
  宮崎拓郎, 宮崎　章
- Organizer
  第46回日本動脈硬化学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26461368
[Presentation] ヒト及びマウス動脈硬化病変において認められるm-カルバイン発現誘導ならびにそのVE-カドヘリン崩壊および動脈硬化進展における役割
- Author(s)
  宮崎拓郎
- Organizer
  コレステロールダイナミクス研究会
- Place of Presentation
  東京丸の内ホテル
- Invited
- Data Source
  KAKENHI-PROJECT-24790784

1. 松本英成 (30861132)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. OHTAKI HIROKAZU (20349062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. SHIODA SEIJI (80102375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Rakwal Randeep (70590850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Tonami Kazuo (70511393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. MIYAZAKI AKIRA (70253721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
7. 佐竹炎 (20280688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小野弥子 (20392376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 若林公平 (50384524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 新家俊郎 (60379419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OBAMA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. NAKAMACHI Tomoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. WATANABE Takuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. SUZAWA Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 金山朱里

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 板部洋之

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# of Collaborated Products: 1 results
17. 大石由美子

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# of Collaborated Products: 1 results
18. 松田恒平

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# of Collaborated Products: 1 results
19. 村上誠

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# of Collaborated Products: 1 results
20. 反町洋之

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# of Collaborated Products: 1 results
21. 上條竜太郎

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# of Collaborated Products: 1 results

Miyazaki Takurou 宮崎 拓郎

MIYAZAKI Takuro 宮崎 拓郎

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プラーク内出血とハプトグロビン遺伝子多型から見た新たな冠動脈イベント予防戦略

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Homeostatic regulation of metabolic organs by splicing factors and its clinical applicationPrincipal Investigator

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Regulation of atheroscllerosis by lymphatic endothelial calpain sysmtemsPrincipal Investigator

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Targeting macrophage pinocytosis in atherosclerosisPrincipal Investigator

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Functional analysis of non-proteolytic calpain to the skeletal muscle development via RhoA activity

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Regulation of macrophage foam cell formation and atherosclerosis by tissue-specific calpains

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Repairing mechanism of human mesenchymal stem cells (hMSCs) via immune regulation on ischemia brain injury

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Regulation of abdominal aortic aneurysms by calpain/calpastatin systemsPrincipal Investigator

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Mechanisms underlying endothelial barrier functions through mechanotransductions : regulatory role of m-calpainPrincipal Investigator

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[Book] mRNAの制御機構の解明と治療薬・ワクチンへの活用2023

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[Journal Article] Calpain and Cardiometabolic Diseases2023

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[Journal Article] 血管系疾患に潜むカルパインシステムの制御異常2022

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[Journal Article] リンパ管機能異常とアテローム性動脈硬化症2022

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[Journal Article] Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling.2022

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Miyazaki Takurou 宮崎拓郎

MIYAZAKI Takuro 宮崎拓郎