Yamaguti Hiroaki 山口浩明

… Alternative Names

山口浩明ヤマグチヒロアキ

YAMAGUCHI Hiroaki 山口浩明

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Researcher Number	80400373
Other IDs
External Links
Affiliation (Current)	2025: 山形大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 山形大学, 医学部, 教授 2019 – 2020: 山形大学, 医学部, 教授 2019: 東北大学, 大学病院, 助教 2018: 東北大学, 大学病院, 准教授 2017: 東北大学, 大学病院, 助教 … More 2014 – 2016: 東北大学, 大学病院, 准教授 2011 – 2013: 北海道大学, 薬学研究科(研究院), 准教授 2012: 北海道大学, 大学院・薬学研究院, 准教授 2010: 東北大学, 病院, 助教 2009: 東北大, 大学病院, 助教 2007 – 2008: Tohoku University, 病院, 助教 2007: 東北大, 大学病院, 助手 2006: 東北大学, 病院, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Applied pharmacology Except Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Drug development chemistry / Physical pharmacy
Keywords	Principal Investigator トランスポーター / 蛍光プローブ / 母乳育児 / 安全性 / 薬物乳汁移行 / 薬物相互作用 / OATP4C1 / 薬物動態 / 相互作用 / 腎排泄 … More / 薬物輸送担体 / ABCC4 / エイコサノイド / 細胞外放出 / プロスタノイド / 腎臓 / 異物排泄 / 薬物動態・代謝学 / イメージング / リアルタイムイメージング / 薬物輸送学 / ハイスループット / 抗癌剤 / OATP1B3 / 薬物スクリーニング … More Except Principal Investigator 胆汁酸 / トランスポーター / モデリング・シミュレーション / 治療薬物モニタリング / 小児感染症治療 / 生理学的薬物速度論解析 / 母集団薬物動態解析 / ペプチドミイメティクス / ライブラリー / ペプチドミメティクス / ヌクレオシド / レゾルビン / 三次元多様性 / シクロプロパン / 黒室 / in silico / 黒質 / SLC10A4 / アフィニティーラベル化 / 誘導体化 / 脳内トランスポーター / 成長ホルモン / 疑似ニュートラルロス / アフィニティー抽出 / ケノデオキシコール酸 / 結合タンパク質 / リン酸化タンパク質 / プロテオーム / 脳 / 機能性器材 / 分析化学 / 可視化 / 薬物動態 / 蛍光プローブ Less

Evidence generation and systematization of drug transfer into breast milk to improve lactation rate in lactating women taking drugsPrincipal Investigator
- Principal Investigator
  
  山口浩明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Yamagata University
The evaluation algorithm of population pharmacokinetics for antimicrobial agent dosage regimen applicable to pediatric
- Principal Investigator
  
  岡田賢二
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Yokohama College of Pharmacy
Participation of OATP4C1 in the pharmacokinetics of drugsPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Hiroaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Yamagata University
  Tohoku University
Medicinal chemistry studies based on the three-dimensional structural diversity-oriented molecular design of pharmacologically active compounds
- Principal Investigator
  
  Shuto Satoshi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Mechanisms of prostanoids release from the cellsPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Hiroaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
  Hokkaido University
Characterization of kidney specific organic anion transporter SLCO4C1Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Hiroaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
抗がん剤の体内動態特性に基づいたがん治療効果と副作用に関する研究Principal Investigator
- Principal Investigator
  
  山口浩明
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Proteomics of bile acid signals
- Principal Investigator
  
  GOTO Junichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tohoku University
Analysis of functional significance of a newly discovered brain-specific transporter
- Principal Investigator
  
  NAKAJIMA Akira
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya University
  Tohoku University
新規薬物動態可視化解析法の開発
- Principal Investigator
  
  菱沼隆則
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Real-time imaging of carrier-mediated transportPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University
トランスポーターを機能性器材として利用した薬物治療法の開発Principal Investigator
- Principal Investigator
  
  山口浩明
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University

[Journal Article] The Use of an Antioxidant Enables Accurate Evaluation of the Interaction of Curcumin on Organic Anion-Transporting Polypeptides 4C1 by Preventing Auto-Oxidation2024
- Author(s)
  Sato Toshihiro、Yagi Ayaka、Yamauchi Minami、Kumondai Masaki、Sato Yu、Kikuchi Masafumi、Maekawa Masamitsu、Yamaguchi Hiroaki、Abe Takaaki、Mano Nariyasu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 2 Pages: 991-991
- DOI
  10.3390/ijms25020991
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15311, KAKENHI-PROJECT-23K06231
[Journal Article] 院外処方箋疑義照会簡素化プロトコールの運用状況の評価および医師・保険薬局へのアンケートに基づいた有用性と問題点の検討2023
- Author(s)
  大橋弥世，木村朱里，高橋尚史，畠山史朗，横枕史，小倉次郎，山口浩明
- Journal Title
  
  医療薬学
  
  Volume: 49 Pages: 423-433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06231
[Journal Article] A hydrolysate of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Cav3.2-dependent pain by sequestering exogenous and endogenous sulfide2023
- Author(s)
  Sekiguchi Fumiko、Koike Nene、Shimada Yasuhiro、Sugimoto Kaho、Masuda Hiroshi、Nakamura Takashi、Yamaguchi Hiroaki、Tanabe Genzoh、Marumoto Shinsuke、Kasanami Yoshihito、Tsubota Maho、Ohkubo Tsuyako、Yoshida Shigeru、Kawabata Atsufumi
- Journal Title
  
  Redox Biology
  
  Volume: 59 Pages: 102579-102579
- DOI
  10.1016/j.redox.2022.102579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06231
[Journal Article] Cost-Effectiveness Analysis of Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib for Inoperable or Recurrent Breast Cancer2023
- Author(s)
  Toshihiro Shida, Motoko Kaneko, Jiro Ogura, Hiroki Sawada, Shiro Hatakeyama, Ichiro Arakawa, Hiroaki Yamaguchi, Tadao Inoue
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 50 Pages: 895-900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06231
[Journal Article] Glutathione depletion results in S-nitrosylation of protein disulfide isomerase in neuroblastoma cells2023
- Author(s)
  Shinji Ono, Jiro Ogura, Hiroki Sugiura, Minami Yamauchi, Atsushi Tanaka, Toshihiro Sato, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano
- Journal Title
  
  Life Sciences
  
  Volume: 316 Pages: 121442-121442
- DOI
  10.1016/j.lfs.2023.121442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05873, KAKENHI-PROJECT-23K06231
[Journal Article] Azelnidipine treatment reduces the expression of Cav1.2 protein2021
- Author(s)
  Fumiaki Nasu, Yutaro Obara, Yosuke Okamoto, Hiroaki Yamaguchi, Kazuya Kurakami, Ikuo Norota, Kuniaki Ishi
- Journal Title
  
  Life Sciences
  
  Volume: 269 Pages: 119043-119043
- DOI
  10.1016/j.lfs.2021.119043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16116, KAKENHI-PROJECT-18K06742
[Journal Article] Simultaneous analysis of drugs administered to lung-transplanted patients using liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring2021
- Author(s)
  Shinya Takasaki, Tensei Hirasawa, Yu Sato, Masamitsu Maekawa, Taku Tsukamoto, Masafumi Kikuchi, Jiro Ogura, Yoshihiro Hayakawa, Yasushi Matsuda, Hisashi Oishi, Tetsu Sado, Masafumi Noda, Yoshinori Okada, Hiroaki Yamaguchi, Nariyasu Mano
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 35 Issue: 6 Pages: 1-8
- DOI
  10.1002/bmc.5067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06742, KAKENHI-PROJECT-19K09040
[Journal Article] Plasma mycophenolic acid concentration and the clinical outcome after lung transplantation2020
- Author(s)
  Yabuki Hiroshi、Matsuda Yasushi、Watanabe Tatsuaki、Eba Shunsuke、Hoshi Fumihiko、Hirama Takashi、Oishi Hisashi、Sado Tetsu、Noda Masafumi、Sakurada Akira、Kikuchi Masafumi、Yamaguchi Hiroaki、Mano Nariyasu、Okada Yoshinori
- Journal Title
  
  Clinical Transplantation
  
  Volume: 34 Issue: 12 Pages: 1-9
- DOI
  10.1111/ctr.14088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09040, KAKENHI-PROJECT-18K06742
[Journal Article] ATP-binding cassette transporter C4 is a prostaglandin D2 exporter in HMC-1 cells2020
- Author(s)
  Nobuaki Tanaka, Junya Kawai, Noriyasu Hirasawa, Nariyasu Mano, Hiroaki Yamaguchi
- Journal Title
  
  Prostaglandins, Leukotrienes & Essential Fatty Acids
  
  Volume: 159 Pages: 102139-102139
- DOI
  10.1016/j.plefa.2020.102139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06742
[Journal Article] Development of a precise quantitative method for monitoring sirolimus in whole blood using LC/ESI?MS/MS2020
- Author(s)
  Shigeta Kensuke、Kikuchi Masafumi、Tanaka Masaki、Takasaki Shinya、Oishi Hisashi、Sado Tetsu、Matsuda Yasushi、Noda Masafumi、Okada Yoshinori、Mano Nariyasu、Yamaguchi Hiroaki
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 34 Issue: 8 Pages: 1-8
- DOI
  10.1002/bmc.4853
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09040, KAKENHI-PROJECT-18K06742
[Journal Article] Limited Sampling Strategy for the Estimation of Mycophenolic Acid and its Acyl Glucuronide Metabolite Area under the Concentration-Time Curve in Japanese Lung Transplant Recipients2019
- Author(s)
  Masaki Tanaka, Masafumi Kikuchi, Shinya Takasaki, Tensei Hirasawa, Kensuke Shigeta, Aoi Noda, Miki Akiba, Yasushi Matsuda, Hisashi Oishi, Tetsu Sado, Masafumi Noda, Yoshinori Okada, Nariyasu Mano, Hiroaki Yamaguchi
- Journal Title
  
  Journal of Pharmacy and Pharmaceutical Sciences
  
  Volume: 22 Pages: 407-417
- DOI
  10.18433/jpps30505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06742
[Journal Article] Estimation of Blood Sirolimus Concentration Based on Tacrolimus Concentration/Dose Normalized by Body Weight Ratio in Lung Transplant Patients2019
- Author(s)
  Masafumi Kikuchi, Kensuke Shigeta, Masaki Tanaka, Shinya Takasaki, Miki Akiba, Hisashi Oishi, Tetsu Sado, Yasushi Matsuda, Masafumi Noda, Yoshinori Okada, Nariyasu Mano, Hiroaki Yamaguchi
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 41 Issue: 5 Pages: 615-619
- DOI
  10.1097/ftd.0000000000000649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06742
[Journal Article] Long-term relationship between everolimus blood concentration and clinical outcomes in Japanese patients with metastatic renal cell carcinoma: a prospective study2019
- Author(s)
  Takasaki Shinya、Yamaguchi Hiroaki、Kawasaki Yoshihide、Kikuchi Masafumi、Tanaka Masaki、Ito Akihiro、Mano Nariyasu
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: 5 Issue: 1 Pages: 6-6
- DOI
  10.1186/s40780-019-0135-5
- Data Source
  KAKENHI-PROJECT-18K06742
[Journal Article] Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease2019
- Author(s)
  Kikuchi Koichi、Saigusa Daisuke、Kanemitsu Yoshitomi、Matsumoto Yotaro、Tsukamoto Hiroki、Abe Takaaki
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1835-1835
- DOI
  10.1038/s41467-019-09735-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K06742, KAKENHI-PROJECT-18K07076, KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-18K08199, KAKENHI-PLANNED-17H06394, KAKENHI-PUBLICLY-18H04805, KAKENHI-PROJECT-19H03557, KAKENHI-PROJECT-19H03675, KAKENHI-PROJECT-17K00856
[Journal Article] Risk Factors for Severe Hyponatremia Related to Cisplatin: A Retrospective Case-Control Study2019
- Author(s)
  Shiro Hatakeyama, Toshihiro Shida, Hiroaki Yamaguchi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 11 Pages: 1891-1897
- DOI
  10.1248/bpb.b19-00477
- NAID
  130007740636
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-11-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06742
[Journal Article] Diagnostic performance evaluation of sulfate-conjugated cholesterol metabolites as urinary biomarkers of Niemann-Pick disease type C2019
- Author(s)
  Masamitsu Maekawa, Aya Narita, Isamu Jinnoh, Takashi Iida, Thorsten Marquardt, Eugen Mengel, Yoshikatsu Eto, Peter T. Clayton, Hiroaki Yamaguchi, Nariyasu Mano
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 494 Pages: 58-63
- DOI
  10.1016/j.cca.2019.03.1610
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06742, KAKENHI-PROJECT-18K15699
[Journal Article] Altered bile acid composition and disposition in a mouse model of non-alcoholic steatohepatitis2019
- Author(s)
  Takahiro Suga, Hiroaki Yamaguchi, Jiro Ogura, Saori Shoji, Masamitsu Maekawa, Nariyasu Mano
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 379 Pages: 114664-114664
- DOI
  10.1016/j.taap.2019.114664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06742
[Journal Article] Involvement of H+-gradient dependent transporter in PGE2 release from A549 cells2019
- Author(s)
  Nobuaki Tanaka, Hiroaki Yamaguchi, Nariyasu Mano
- Journal Title
  
  Prostaglandins Leukot Essent Fatty Acids
  
  Volume: 149 Pages: 30-36
- DOI
  10.1016/j.plefa.2019.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06742
[Journal Article] Characterization of conjugated and unconjugated bile acid transport via human organic solute transporter α/β2019
- Author(s)
  Suga Takahiro、Yamaguchi Hiroaki、Ogura Jiro、Mano Nariyasu
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1861 Issue: 5 Pages: 1023-1029
- DOI
  10.1016/j.bbamem.2019.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18J11662, KAKENHI-PROJECT-18K06742
[Journal Article] Organogermanium suppresses cell death due to oxidative stress in normal human dermal fibroblasts2019
- Author(s)
  Tomoya Takeda, Sota Doiyama, Junya Azumi, Yasuhiro Shimada, Yoshihiko Tokuji, Hiroaki Yamaguchi, Kosuke Nagata, Naoya Sakamoto, Hisashi Aso, Takashi Nakamura
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 13637-13637
- DOI
  10.1038/s41598-019-49883-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06742, KAKENHI-PROJECT-17H03784, KAKENHI-PROJECT-18H02326
[Journal Article] Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors2019
- Author(s)
  Ichinose W, Cherepanov SM, Shabalova AA, Yokoyama S, Yuhi T, Yamaguchi H, Watanabe A, Yamamoto Y, Okamoto H, Horike S, Terakawa J, Daikoku T, Watanabe M, Mano N, Higashida H, Shuto S
- Journal Title
  
  J Med Chem
  
  Volume: - Issue: 7 Pages: 3297-3310
- DOI
  10.1021/acs.jmedchem.8b01691
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-18K06742, KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-19H00388
[Journal Article] Comparison of PETINIA and LC-MS/MS for determining plasma mycophenolic acid concentrations in Japanese lung transplant recipients2018
- Author(s)
  Kikuchi Masafumi、Tanaka Masaki、Takasaki Shinya、Takahashi Akiko、Akiba Miki、Matsuda Yasushi、Noda Masafumi、Hisamichi Kanehiko、Yamaguchi Hiroaki、Okada Yoshinori、Mano Nariyasu
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: 4 Issue: 1 Pages: 7-7
- DOI
  10.1186/s40780-018-0101-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06742
[Journal Article] Impact of clinical factors and UGT1A9 and CYP2B6 genotype on inter-individual differences in propofol pharmacokinetics2018
- Author(s)
  Kanaya Akihiro、Sato Toshihiro、Fuse Nobuo、Yamaguchi Hiroaki、Mano Nariyasu、Yamauchi Masanori
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 32 Issue: 2 Pages: 236-243
- DOI
  10.1007/s00540-018-2470-3
- NAID
  40021526163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06742
[Journal Article] Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation2018
- Author(s)
  Watanabe Takashi、Saito Takahiro、Rico Evelyn Marie Gutierrez、Hishinuma Eiji、Kumondai Masaki、Maekawa Masamitsu、Oda Akifumi、Saigusa Daisuke、Saito Sakae、Yasuda Jun、Nagasaki Masao、Minegishi Naoko、Yamamoto Masayuki、Yamaguchi Hiroaki、Mano Nariyasu、Hirasawa Noriyasu、Hiratsuka Masahiro
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 156 Pages: 420-430
- DOI
  10.1016/j.bcp.2018.09.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08233, KAKENHI-PROJECT-17K08257, KAKENHI-PROJECT-18K06742, KAKENHI-PROJECT-15K09464
[Journal Article] Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals2018
- Author(s)
  Hishinuma Eiji、Narita Yoko、Saito Sakae、Maekawa Masamitsu、Akai Fumika、Nakanishi Yuya、Yasuda Jun、Nagasaki Masao、Yamamoto Masayuki、Yamaguchi Hiroaki、Mano Nariyasu、Hirasawa Noriyasu、Hiratsuka Masahiro
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 46 Issue: 8 Pages: 1083-1090
- DOI
  10.1124/dmd.118.081737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06742
[Journal Article] Shifting the linear range in electrospray ionization by in-source collision-induced dissociation2016
- Author(s)
  石井英昭、山口浩明、眞野成康
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 64 Pages: 356-359
- NAID
  130005141021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen2015
- Author(s)
  小倉次郎、桑山果織、佐々木俊一、金子千紘、小泉貴寛、矢部敬祐、辻本高志、竹野玲子、高谷厚、小林正紀、山口浩明、井関健
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 97 Issue: 1 Pages: 89-98
- DOI
  10.1016/j.bcp.2015.06.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Involvement of histidine residue His382 in pH regulation of MCT4 activity2015
- Author(s)
  佐々木将太郎、小林正紀、二木悠哉、小倉次郎、山口浩明、井関健
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 4 Pages: e0122738-e0122738
- DOI
  10.1371/journal.pone.0122738
- NAID
  120005621882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Simultaneous quantification of leukotrienes and hydroxyeicosatetraenoic acids in cell culture medium using liquid chromatography/tandem mass spectrometry2015
- Author(s)
  古堅彩子、山口浩明、眞野成康
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 29 Issue: 7 Pages: 1084-1093
- DOI
  10.1002/bmc.3395
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Prevalence, determinants, and reasons for non-reporting of adverse drug reaction by pharmacists in Miyagi and Hokkaido regions of Japan2015
- Author(s)
  小原拓、山口浩明、佐藤倫広、飯田優太郎、酒井隆全、青木良子、天沼喜美子、村井ユリ子、松浦正樹、佐藤真由美、大久保孝義、井関健、眞野成康
- Journal Title
  
  Advances in Pharmacoepidemiology & Drug Safety
  
  Volume: 4 Issue: 05 Pages: 191-191
- DOI
  10.4172/2167-1052.1000191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] A novel extraction method based on a reversible chemical conversion for the LC/MS/MS analysis of the stable organic germanium compound Ge-132.2015
- Author(s)
  山口浩明、島田康弘、武田知也、中村宜司、眞野成康
- Journal Title
  
  Analytical Chemistry
  
  Volume: 87 Issue: 4 Pages: 2042-2047
- DOI
  10.1021/ac504466u
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Focused metabolomics using liquid chromatography/electrospray ionization tandem mass spectrometry for analysis of urinary conjugated cholesterol metabolites from patients with Niemann-Pick disease type C and 3β-hydroxysteroid dehydrogenase deficiency2015
- Author(s)
  Masamitsu Maekawa, Miki Shimada, Kousaku Ohno, Masami Togawa, Hiroshi Nittono, Takashi Iida, Alan F Hofmann, Junichi Goto, Hiroaki Yamaguchi, and Nariyasu Mano
- Journal Title
  
  Annals of Clinical Biochemistry
  
  Volume: 52(5) Issue: 5 Pages: 576-587
- DOI
  10.1177/0004563214568871
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01809, KAKENHI-PROJECT-25460184, KAKENHI-PROJECT-25460185
[Journal Article] Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS.2015
- Author(s)
  A. Sasaki, H. Fukuda, N. Shiida, N. Tanaka, A. Furugen, J. Ogura, S. Shuto, N. Mano, H. Yamaguchi
- Journal Title
  
  Anal. Bioanal. Chem
  
  Volume: 407 Issue: 6 Pages: 1625-1639
- DOI
  10.1007/s00216-014-8412-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25460184, KAKENHI-PROJECT-15H02495
[Journal Article] Transport of eicosapentaenoic acid-derived PGE3, PGF3α, and TXB3 by ABCC4.2014
- Author(s)
  田中伸明、山口浩明、眞野成康
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 10 Pages: e109270-e109270
- DOI
  10.1371/journal.pone.0109270
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Quantification of intracellular and extracellular eicosapentaenoic acid-derived 3-series prostanoids by liquid chromatography/electrospray ionization tandem mass spectrometry.2014
- Author(s)
  田中伸明、山口浩明、古堅彩子、小倉次郎、小林正紀、山田武宏、眞野成康、井関健
- Journal Title
  
  Prostaglandins, Leukotrienes and Essential Fatty Acids
  
  Volume: 91 Issue: 3 Pages: 61-71
- DOI
  10.1016/j.plefa.2014.04.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.2014
- Author(s)
  佐藤紀宏、山口浩明、古川巧馬、阿部高明、眞野成康
- Journal Title
  
  Journal of Pharmacy & Pharmaceutical Sciences
  
  Volume: 17 Pages: 475-484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Quantification of intracellular and extracellular digoxin and ouabain by liquid chromatography/electrospray ionization tandem mass spectrometry.2014
- Author(s)
  山口浩明、宮森和明、佐藤紀宏、小倉次郎、小林正紀、山田武宏、眞野成康、井関健
- Journal Title
  
  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
  
  Volume: 972 Pages: 73-80
- DOI
  10.1016/j.jchromb.2014.09.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Renal Uptake of Substrates for Organic Anion Transporters Oat1 and Oat3 and Organic Cation Transporters Oct1 and Oct2 is Altered in Rats with Adenine-Induced Chronic Renal Failure2013
- Author(s)
  駒澤宏紀、山口浩明ら、他4名
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 102巻 Issue: 3 Pages: 1086-1094
- DOI
  10.1002/jps.23433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790168
[Journal Article] Regulation of the Expression and Activity of Glucose and Lactic Acid Metabolism-Related Genes by Protein Kinase C in Skeletal Muscle Cells2013
- Author(s)
  Otake S, Kobayashi M, Narumi K, Sasaki S, Kikutani Y, Furugen A, Watanabe M, Takahashi N, Ogura J, Yamaguchi H, Iseki K
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 36 Issue: 9 Pages: 1435-1439
- DOI
  10.1248/bpb.b13-00141
- NAID
  130003361512
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790138, KAKENHI-PROJECT-25460184
[Journal Article] Crucial residue involved in L-lactate recognition by human monocarboxylate transporter 4 (hMCT4)2013
- Author(s)
  Sasaki S, Kobayashi M, Futagi Y, Ogura J, Yamaguchi H, Takahashi N, Iseki K
- Journal Title
  
  PLoS ONE.
  
  Volume: 8 Issue: 7 Pages: 67690-67690
- DOI
  10.1371/journal.pone.0067690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790138, KAKENHI-PROJECT-25460184
[Journal Article] Quantitative determination of paclitaxel and its metabolites, 6a-hydroxypaclitaxel and p-3’-hydroxypaclitaxel, in human plasma using column-switching liquid chromatography/tandem mass spectrometry2013
- Author(s)
  Hiroaki Yamaguchi, Asuka Fujikawa, Hajime Ito, Nobuaki Tanaka, Ayako Furugen, Kazuaki Miyamori, Natsuko Takahashi, Jiro Ogura, Masaki Kobayashi, Takehiro Yamada, Nariyasu Mano, Ken Iseki
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 27 Issue: 4 Pages: 539-544
- DOI
  10.1002/bmc.2826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790168, KAKENHI-PROJECT-24659012
[Journal Article] Contribution of multidrug resistance-associated proteins (MRPs) to the release of prostanoids from A549 cells.2013
- Author(s)
  古堅彩子、山口浩明、田中伸明、椎田成美、小倉次郎、小林正紀、井関健
- Journal Title
  
  Prostaglandins & Other Lipid Mediators
  
  Volume: 106 Pages: 37-44
- DOI
  10.1016/j.prostaglandins.2013.08.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Effect of oxidative stress on expression and function of human and rat organic anion transporting polypeptides in the liver.2013
- Author(s)
  辻本高志、小倉次郎、桑山果織、小泉貴寛、佐々木駿一、寺田悠介、小林正紀、山口浩明、井関健
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 458 Issue: 2 Pages: 262-271
- DOI
  10.1016/j.ijpharm.2013.10.013
- NAID
  120005372307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Megalin contributes to kidney accumulation and nephrotoxicity of colistin.2013
- Author(s)
  鈴木貴宏、山口浩明、小倉次郎、小林正紀、山田武宏、井関健
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 57 Issue: 12 Pages: 6319-6324
- DOI
  10.1128/aac.00254-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Intestinal ischemia-reperfusion suppresses biliary excretion of hepatic organic anion transporting polypeptides substrate.2013
- Author(s)
  丸山創、小倉次郎、藤川あす歌、寺田悠介、辻本高志、小泉貴寛、桑山果織、小林正紀、山口浩明、井関健
- Journal Title
  
  Journal of Pharmacy & Pharmaceutical Sciences
  
  Volume: 16 Pages: 722-731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Regulation of multidrug resistance protein 2 (MRP2, ABCC2) expression by statins: involvement of SREBP-mediated gene regulation.2013
- Author(s)
  小林正紀、合田圭祐、知崎郁美、浅田晃司、小倉次郎、高橋夏子、小西徹、越田悠介、佐々木将太郎、山口浩明、井関健
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 452 Issue: 1-2 Pages: 36-41
- DOI
  10.1016/j.ijpharm.2013.04.019
- NAID
  120005372304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460184
[Journal Article] Quantification of intact carboplatin in human plasma ultrafitrates using hydrophilic interaction liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study2013
- Author(s)
  Hajime Ito, Hiroaki Yamaguchi, Asuka Fujikawa, Narumi Shiida, Nobuaki Tanaka, Jiro Ogura, Masaki Kobayashi, Takehiro Yamada, Nariyasu Mano, Ken Iseki
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 917-918 Pages: 18-23
- DOI
  10.1016/j.jchromb.2012.11.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790168, KAKENHI-PROJECT-24659012
[Journal Article] A rapid and sensitive LC/ESI-MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study2012
- Author(s)
  山口浩明ら、他11名
- Journal Title
  
  Chromatography B
  
  Volume: 893-894巻 Pages: 157-161
- DOI
  10.1016/j.jchromb.2012.02.003
- NAID
  120004856992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790168
[Journal Article] A full validated hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the quantification of oxaliplatin in human plasma ultrafiltrates2012
- Author(s)
  伊藤創、山口浩明ら、他10名
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 71巻 Pages: 99-103
- DOI
  10.1016/j.jpba.2012.08.010
- NAID
  120004857025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790168, KAKENHI-PROJECT-24659012
[Journal Article] Intestinal Ischemia-Reperfusion Increases Efflux for Uric Acid Via Paracellular Route in the Intestine, but Decreases that Via Transcellular Route Mediated by BCRP2012
- Author(s)
  小倉次郎、桑山果織、山口浩明ら、他11名
- Journal Title
  
  Journal of Pharmacy & Pharmaceutical Sciences
  
  Volume: 15巻 Pages: 295-304
- URL
  http://ejournals.library.ualberta.ca/index.php/JPPS/issue/view/1237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790168
[Journal Article] The Decrease in Farnesoid X Receptor, Pregnane X Receptor and Constitutive Androstane Receptor in the Liver after Intestinal Ischemia-Reperfusion2012
- Author(s)
  小倉次郎、寺田悠介、山口浩明ら、他11名
- Journal Title
  
  Journal of Pharmacy& Pharmaceutical Sciences
  
  Volume: 15巻 Pages: 616-631
- URL
  http://ejournals.library.ualberta.ca/index.php/JPPS/issue/view/1388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790168
[Journal Article] スタチンの骨格筋障害に及ぼす酸・アルカリ化誘導剤の影響2012
- Author(s)
  小林正紀、日高和宏、知嵜郁美、高橋夏子、小倉次郎、板垣史郎、平野剛、山口浩明、井関健
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 132 Pages: 609-615
- NAID
  130001888677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790168
[Journal Article] Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: The role of protein kinase C (PKC)2012
- Author(s)
  鳴海克哉、小林正紀、山口浩明ら、他8名
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 428巻 Issue: 1-2 Pages: 25-32
- DOI
  10.1016/j.ijpharm.2012.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790168
[Journal Article] スタチンの骨格筋障害に及ぼす酸・アルカリ化誘導剤の影響2012
- Author(s)
  小林正紀、日高和宏、山口浩明ら、他6名
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 132巻 Pages: 609-615
- NAID
  130001888677
- URL
  https://www.jstage.jst.go.jp/article/yakushi/132/5/132_5_609/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790168
[Journal Article] Production of ^<18>O-single labeled peptide fragments during trypsin digestion of proteins for quantitative proteomics using nanoLC/ESI-MS/MS.2011
- Author(s)
  Masaru Mori, Kohei Abe, Hiroaki Yamaguchi, Junichi Goto, Miki Shimada, Nariyasu Mano
- Journal Title
  
  J.Proteome Res. 9
  
  Pages: 3741-3749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390009
[Journal Article] Quantitation of five prostanoids in both cultured cells and media by liquid chromatography/electrosprav ionization tandem mass spectrometry2011
- Author(s)
  Ayako Furugen
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 879 Issue: 30 Pages: 3378-3385
- DOI
  10.1016/j.jchromb.2011.09.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390006, KAKENHI-PROJECT-22659007, KAKENHI-PROJECT-23790168
[Journal Article] Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes.2011
- Author(s)
  Hiroaki Yamaguchi, Toshiko Takeuchi, Masahiro Okada, Minako Kobayashi, Michiaki Unno, Takaaki Abe, Junichi Goto, Takanori Hishinuma, Miki Shimada, Nariyasu Mano
- Journal Title
  
  Biol.Pharm.Bull. 34
  
  Pages: 389-395
- NAID
  130000657818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390009
[Journal Article] An accurate quantitative LC/ESI-MS/MS method for sirolimus in human whole blood.2011
- Author(s)
  Nariyasu Mano, Mayumi Sato, Marina Nozawa, Yotaro Matsumoto, Masaru Mori, Hiroaki Yamaguchi, Junichi Goto, Miki Shimada
- Journal Title
  
  J.Chromatogr. B 879
  
  Pages: 987-992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390009
[Journal Article] Identification and elimination of ion suppression in the quantitative analysis of sirolimus in human blood by LC/ESI-MS/MS.2011
- Author(s)
  Nariyasu Mano, Marina Nozawa, Mayumi Sato, Masaru Mori, Hiroaki Yamaguchi, Katsuhiro Kanda, Makoto Nogami, Junichi Goto, Miki Shimada
- Journal Title
  
  J. Chromatogr. B 879
  
  Pages: 968-974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390009
[Journal Article] Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes2011
- Author(s)
  Hiroaki Yamaguchi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 34 Pages: 389-395
- NAID
  130000657818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390009
[Journal Article] Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1 : Estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C12010
- Author(s)
  Hiroaki Yamaguchi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics (in press)
- NAID
  10027583082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390009
[Journal Article] Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1 : Estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1.2010
- Author(s)
  Hiroaki Yamaguchi, Misa Sugie, Masahiro Okada, Tsuyoshi Mikkaichi, Takafumi Toyohara, Takaaki Abe, Junichi Goto, Takanori Hishinuma, Miki Shimada, Nariyasu Mano
- Journal Title
  
  Drug Metab. Pharmacokinet. 25
  
  Pages: 314-317
- NAID
  10027583082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390009
[Journal Article] Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C 1 : Estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C12010
- Author(s)
  Hiroaki Yamaguchi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 25 Pages: 314-317
- NAID
  10027583082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390009
[Journal Article] Analysis of phosphorylated peptides by double pseudo-neutral loss extraction coupled with derivatization using N-(4-bromobenzoyl)aminoethanethiol.2009
- Author(s)
  Nariyasu Mano, Sayaka Aoki, Takuma Yamazaki, Yoko Nagaya, Masaru Mori, Kohei Abe, Miki Shimada, Hiroaki Yamaguchi, Takaaki Goto, Junichi Goto
- Journal Title
  
  Anal.Chem. 81
  
  Pages: 9395-9401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390009
[Journal Article] Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes2008
- Author(s)
  山口浩明ら、ほか8名
- Journal Title
  
  Cancer Lett 260巻
  
  Pages: 163-169
- NAID
  120002400578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790384
[Journal Article] Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes2008
- Author(s)
  Hiroaki Yamaguchi
- Journal Title
  
  Cancer Letter 260
  
  Pages: 163-169
- NAID
  120002400578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790384
[Journal Article] Simple quantification of lansoprazole and rabeprazole concentrations in human serum by liquid chromatography/tandem mass spectrometry2008
- Author(s)
  Hishinuma T, Suzuki K, Yamaguchi H, Yamagishi H, Koike T, Ohara S, Shimosegawa T, Mano N, Goto J
- Journal Title
  
  J Chromatogr B Analyt Technol Biomed Life Sci
  
  Volume: 870 Pages: 38-45
- NAID
  10028002445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390044
[Journal Article] Rapid screening of antineoplastic candidates for the human organic ani on transporter OATP1B3 substrates using fluorescent probes2008
- Author(s)
  Hiroaki Yamaguchi
- Journal Title
  
  Cancer Letter 260
  
  Pages: 163-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390009
[Journal Article] Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes.2008
- Author(s)
  Hiroaki Yamaguchi, et. at.
- Journal Title
  
  Cancer Lett 260
  
  Pages: 163-169
- NAID
  120002400578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790384
[Journal Article] Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes.2008
- Author(s)
  Yamaguchi H, Kobayashi M, Okada M, Takeuchi T, Unno M, Abe T, Goto J, Hishinuma T, Mano N.
- Journal Title
  
  Cancer Lett 260
  
  Pages: 163-169
- NAID
  120002400578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659031
[Journal Article] Simple quantification of lansoprazole and rabeprazole concentrations in humanserum by liquid chromatography/tandem mass spectrometry2008
- Author(s)
  菱沼隆則、鈴木香織、山口浩明ら、ほか6名
- Journal Title
  
  J Chromatogr B 870巻
  
  Pages: 38-45
- NAID
  10028002445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790384
[Journal Article] Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides2008
- Author(s)
  Cornelia de Wolf、Robert Jansen、山口浩明ら、ほか5名
- Journal Title
  
  Mol Cancer Ther 7巻
  
  Pages: 3092-3102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790384
[Journal Article] Genetic variation in ABCB1 influences paclitaxel pharmacokinetics in Japanese patients with ovarian cancer2006
- Author(s)
  Hiroaki Yamaguchi et al.
- Journal Title
  
  Int J Gynecol Cancer 16・3
  
  Pages: 979-985
- Data Source
  KAKENHI-PROJECT-18890016
[Journal Article] Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B32006
- Author(s)
  Hiroaki Yamaguchi et al.
- Journal Title
  
  J Lipid Res 47・6
  
  Pages: 1196-1202
- NAID
  120004857027
- Data Source
  KAKENHI-PROJECT-18890016
[Presentation] 機械学習を用いた患者が苦痛と感じる症状の発現パターン分類モデルの構築2023
- Author(s)
  志田敏宏，早坂達哉，伊藤麻里，鹿野たかね，小倉次郎，山口浩明
- Organizer
  医療薬学フォーラム2023/第31回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K06231
[Presentation] 薬物輸送実験に基づくミルタザピンの母乳移行メカニズムの解明2023
- Author(s)
  畠山史朗，小倉次郎，山口亜耶子，志田敏宏，山口浩明
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-23K06231
[Presentation] 薬学部病院実務実習における他職種業務見学プログラムの効果と課題2023
- Author(s)
  小倉次郎, 志田敏宏, 畠山史朗, 山口浩明
- Organizer
  医療薬学フォーラム2023/第31回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K06231
[Presentation] 患者アウトカムを改善するためいの研究能力と専門性を備えた薬剤師の育成2023
- Author(s)
  山口浩明
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-23K06231
[Presentation] 山形大学医学部附属病院における治験薬管理について2023
- Author(s)
  須藤将裕，豊田優，阿部佐智子，小倉次郎，山口浩明，鈴木民夫
- Organizer
  医療薬学フォーラム2023/第31回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K06231
[Presentation] 新型コロナウイルス感染症治療薬レムデシビルおよびGS-441524の腎排泄および薬物相互作用におけるOATP4C1の役割2021
- Author(s)
  佐藤紀宏、前川正充、阿部高明、山口浩明、眞野成康
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] 手術不能または再発乳がんに対するCDK4/6阻害薬パルボシクリブの臨床判断分析を用いた臨床評価2021
- Author(s)
  金子基子、志田敏宏、荒川一郎、澤田広樹、小倉次郎、山口浩明、井上忠夫
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] 肺移植後患者における薬物療法個別化に向けて2020
- Author(s)
  山口浩明
- Organizer
  日本病院薬剤師会東北ブロック第10回学術大会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] JADERを用いた白金系抗がん薬投与による低ナトリウム血症に関連した中枢神経症状の検討2020
- Author(s)
  畠山史朗、加藤祐太、小原拓、志田敏宏、山口浩明
- Organizer
  日本病院薬剤師会東北ブロック第10回学術大会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] ヘム生合成系初発酵素5-アミノレブリン酸合成酵素1(ALAS1)遺伝子破壊マウスにおけるグルコース刺激インスリン分泌異常2020
- Author(s)
  武田和也、van Wilk Koen、木村朋寛、岡野聡、斉藤真一、山口浩明、児玉健、高橋研、田中徹、中島元夫、中島修
- Organizer
  第93回日本生化学学会大会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] イヌサフラン誤食によりコルヒチン中毒を発症した患者への薬剤師の関わり2019
- Author(s)
  矢内　一成、鈴木　博也、小林　正和、赤坂　和俊、山口　浩明、眞野　成康
- Organizer
  第２９回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] スニチニブのTDM普及に向けて2019
- Author(s)
  山口浩明、髙﨑新也、菊地正史、川崎芳英、荒井陽一、眞野成康
- Organizer
  日本臨床腫瘍薬学会学術大会2019
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] 急性薬毒物分析を保険診療の面から考える～現状と可能性～2019
- Author(s)
  山口　浩明
- Organizer
  第４１回日本中毒学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] 経口がん分子標的薬の個別化投与設計に向けた取り組み2019
- Author(s)
  山口　浩明、髙﨑　新也、菊地　正史、川崎　芳英、伊藤　明宏、眞野　成康
- Organizer
  日本薬剤学会第３４年会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] ヒト血漿中脂肪酸ヒドロキシ化脂肪酸の定量法の開発2019
- Author(s)
  山口　浩明、渡邉　亜侑、眞野　成康
- Organizer
  第３０回日本臨床化学会東北支部総会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] Pharmacokinetic analysis based on clinical chemistry2019
- Author(s)
  Hiroaki Yamaguchi
- Organizer
  The International Symposium of Health Care Technology, Drug Discovery and Chemical Biology 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] トランスポーターを介した経口分子標的抗がん薬の相互作用2018
- Author(s)
  山口浩明、眞野成康
- Organizer
  第28回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] 東北病院薬剤師会員の学術研究に関する実態調査2018
- Author(s)
  山口浩明、小林智徳、小原拓、赤嶺由美子、朝賀純一、芦埜和幸、大原宏司、大村雅之、田村健悦、富岡佳久、豊口禎子、藤原洋之、細井一広、渡辺剛
- Organizer
  日本病院薬剤師会東北ブロック第8回学術大会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] 臨床化学研究における質量分析の貢献治療効果の最大化を目指した経口抗がん薬の治療薬物モニタリング2018
- Author(s)
  高崎新也、川崎芳英、菊地正史、田中雅樹、山口浩明、眞野成康
- Organizer
  第43回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-18K06742
[Presentation] 本邦の薬剤師におけるファーマコビジランスに関する認識と展望2016
- Author(s)
  小原拓、吉田真貴子、山口浩明、赤坂和俊、松浦正樹、佐藤真由美、村井ユリ子、土屋文人、北田光一、眞野成康
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] 本邦の薬剤師における副作用報告経験の実体2015
- Author(s)
  松浦正樹、小原拓、山口浩明、村井ユリ子、土屋文人、北田光一、眞野成康
- Organizer
  日本病院薬剤師会東北ブロック第５回学術大会
- Place of Presentation
  山形テルサ（山形県山形市）
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] 本邦のファーマコビジランスに関する薬剤師の認識2015
- Author(s)
  小原拓、山口浩明、松浦正樹、村井ユリ子、土屋文人、北田光一、眞野成康
- Organizer
  第１８回日本医薬品情報学会総会・学術大会
- Place of Presentation
  岡山大学創立五十周年記念館（岡山県岡山市）
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] 薬毒物中毒原因物質のLC/MS/MS分析システムの検討2015
- Author(s)
  前川正充、小梶哲雄、菊地正史、田中雅樹、中曽根正皓、野田あおい、矢内一成、鈴木博也、赤坂和俊、久道周彦、山口浩明、眞野成康
- Organizer
  第２５回日本医療薬学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] LC/ESI-MS/MSを用いる血中キヌレニン経路代謝物の一斉定量法の開発2015
- Author(s)
  原佳史、山口浩明、眞野成康
- Organizer
  第２８回バイオメディカル分析科学シンポジウム
- Place of Presentation
  長崎大学文教キャンパス（長崎県長崎市）
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] イトラコナゾールの併用によりシロリムストラフ濃度が高値を示したリンパ脈管筋腫症患者の2例2015
- Author(s)
  菊地正史、野田あおい、田中雅樹、高橋阿希子、松田安史、星川康、久道周彦、山口浩明、岡田克典、眞野成康
- Organizer
  第２５回日本医療薬学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] 分離分析法を活用したTDM2015
- Author(s)
  山口浩明
- Organizer
  第３２回日本TDM学会・学術大会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] LC/ESI-MS/MSを用いた尿中アシルカルニチンの一斉定量法の構築2015
- Author(s)
  阿部一樹、鈴木裕之、山口浩明、眞野成康
- Organizer
  第２８回バイオメディカル分析科学シンポジウム
- Place of Presentation
  長崎大学文教キャンパス（長崎県長崎市）
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] 可逆的化学変換を利用した新規抽出法による有機ゲルマニウム化合物Ge-132定量法の開発2015
- Author(s)
  山口浩明、島田康弘、武田知也、中村宜司、眞野成康
- Organizer
  第２８回バイオメディカル分析科学シンポジウム
- Place of Presentation
  長崎大学文教キャンパス（長崎県長崎市）
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] 尿中抱合型コレステロール代謝物によるニーマンピック病C型の化学診断の可能性2015
- Author(s)
  前川正充、島田美樹、飯田隆、成田綾、山口浩明、眞野成康
- Organizer
  第３７回胆汁酸研究会
- Place of Presentation
  横浜ホテルニューグランド（神奈川県横浜市）
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] HILIC/MS/MSによるヒト血漿中5-FU及び代謝物の一斉測定系の確立2015
- Author(s)
  石井英昭、島田美樹、山口浩明、眞野成康
- Organizer
  第２８回バイオメディカル分析科学シンポジウム
- Place of Presentation
  長崎大学文教キャンパス（長崎県長崎市）
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] アキシチニブの血中濃度が上昇しなかった腎細胞癌患者の一例2015
- Author(s)
  野田あおい、田中雅樹、高﨑新也、鈴木裕之、菊地正史、川崎芳英、伊藤明宏、久道周彦、山口浩明、荒井陽一、眞野成康
- Organizer
  第２５回日本医療薬学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] ニーマンピック病C型の診断マーカーとしての尿中抱合型コレステロール代謝物の性能評価2015
- Author(s)
  前川正充、成田綾、大野耕策、飯田隆、島田美樹、山口浩明、眞野成康
- Organizer
  第５５回日本臨床化学会年次学術集会
- Place of Presentation
  大阪大学コンベンションセンター（大阪府吹田市）
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] Identification of cancer specific-transporter mediated compounds2013
- Author(s)
  山口浩明
- Organizer
  NIH-Tohoku University-JSPS Symposium
- Place of Presentation
  艮陵会館（宮城県）
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] DCF療法（ドセタキセル、シスプラチン、5-FU併用療法）における各抗がん薬の血中濃度解析2013
- Author(s)
  山口浩明
- Organizer
  日本医療薬学会第２３回年会
- Place of Presentation
  仙台国際センター（宮城県）
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] ALTERATION OF KIDNEY TRANSPORTERS IN ADENINE-INDUCED CHRONIC RENAL FAILURE RATS2013
- Author(s)
  山口浩明
- Organizer
  28th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] Contribution of multidrug resistance-associated proteins (MRP) tothe release of prostanoids from human lung adenocarcinoma epithelial A549 cells2012
- Author(s)
  古堅彩子、山口浩明、田中伸明、椎田成美、井関健
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] SLCO1B3-specific compound LST-022012
- Author(s)
  阿部高明、山口浩明、後藤順一、眞野成康
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] DCF療法における各抗がん薬血中濃度の解析2012
- Author(s)
  山口浩明
- Organizer
  第46回医療薬学公開シンポジウム
- Place of Presentation
  にぎわい交流館(秋田県)(招待講演)
- Year and Date
  2012-07-28
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] The decrease in bcrp transport activity after intestinal ischemiareperfusion2011
- Author(s)
  小倉次郎、桑山果織、高谷厚、寺田悠介、辻本高志、小泉貴寛、山口浩明、井関健
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島国際会議場(広島県)
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] 臨床検査値の変動から推測されるスタチン系薬物由来の副作用発生率の解析研究2011
- Author(s)
  落合愛美、小林正紀、川岸亨、笠師久美子、山口浩明、山田武宏、井関健
- Organizer
  第21回日本医療薬学会年会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] Statins regulate multidrug resistance-associated protein 2 (MRP2, ABCC2) expression and function: involvement of SREBP-1 mediated gene regulation2011
- Author(s)
  小林正紀、合田圭祐、知嵜郁美、山口浩明、井関健
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島国際会議場(広島県)
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] PKCを介した糖代謝制御およびMCT4発現変動への関連性2011
- Author(s)
  大竹翔、鳴海克哉、小林正紀、山口浩明、井関健
- Organizer
  第21回日本医療薬学会年会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] LC/ESI-MS/MSによる血中ドセタキセルの簡易定量法の構築とその臨床応用2011
- Author(s)
  山口浩明、藤川あす歌、伊藤創、田中伸明、山田武宏、眞野成康、井関健
- Organizer
  第22回クロマトグラフィー科学会議
- Place of Presentation
  東北大学(仙台市)
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] LC/ESI-MS/MS による血中ドセタキセルの簡易定量法の構築とその臨床応用2011
- Author(s)
  山口浩明、藤川あす歌、伊藤創、田中伸明、山田武宏、眞野成康、井関健
- Organizer
  第22回クロマトグラフィー科学会議
- Place of Presentation
  東北大学（仙台市）
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] 臨床検査値の変動から推測されるスタチン系薬物由来の副作用発生率の解析研究2011
- Author(s)
  落合愛美、小林正紀、川岸亨、笠師久美子、山口浩明、山田武宏、井関健
- Organizer
  第21回日本医療薬学会年会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] 抗悪性腫瘍薬オキサリプラチンのHILIC/MS/MSによる血中濃度測定法の確立2011
- Author(s)
  伊藤創、山口浩明、藤川あす歌、山田武宏、眞野成康、井関健
- Organizer
  第22回クロマトグラフィー科学会議
- Place of Presentation
  東北大学(仙台市)
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] THE DECREASE IN BCRP TRANSPORT ACTIVITY AFTER INTESTINAL ISCHEMIA-REPERFUSION2011
- Author(s)
  小倉　次郎、桑山　果織、高谷　厚、寺田　悠介、辻本　高志、小泉　貴寛、山口　浩明、井関　健
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島国際会議場（広島県）
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] LC/MS/MS analysis of extracellular and intracellular prsostanoids in cultured cells: evaluation of functionalimportance of mrp4 in prostanoid release2011
- Author(s)
  古堅彩子、山口浩明、井関健
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島国際会議場(広島県)
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] LC/MS/MS ANALYSIS OF EXTRACELLULAR AND INTRACELLULAR PRSOSTANOIDS IN CULTURED CELLS: EVALUATION OF FUNCTIONAL IMPORTANCE OF MRP4 IN PROSTANOID RELEASE2011
- Author(s)
  古堅　彩子、山口　浩明、井関　健
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島国際会議場（広島県）
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] 抗悪性腫瘍薬オキサリプラチンのHILIC/MS/MSによる血中濃度測定法の確立2011
- Author(s)
  伊藤　創、山口　浩明、藤川　あす歌、山田　武宏、眞野　成康、井関　健
- Organizer
  第22回クロマトグラフィー科学会議
- Place of Presentation
  東北大学（仙台市）
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] Statins regulate multidrug resistance-associated protein 2 (MRP2, ABCC2) expression and function: involvement of SREBP-1 mediated gene regulation2011
- Author(s)
  小林　正紀、合田　圭祐、知嵜　郁美、山口　浩明、井関　健
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島国際会議場（広島県）
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] PKCを介した糖代謝制御およびMCT4発現変動への関連性2011
- Author(s)
  大竹翔、鳴海克哉、小林正紀、山口浩明、井関健
- Organizer
  第21回日本医療薬学会年会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] Analysis of chenodeoxycholate-binding proteins in rat brain and pituitary by mass spectrometry coupled with cleavable ffinity extraction.2010
- Author(s)
  Nariyasu Mano, Kohei Abe, Masaru Mori, Koichi Sato, Hiroaki Yamaguchi, Miki Shimada, Takaaki Goto, Junichi Goto
- Organizer
  XXI International Bile Acid Meeting ; Bile Acids as Metabolic Integrators and Therapeutics Freiburg
- Place of Presentation
  ドイツ
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] ^<18>O一置換標識法によるプロテオームの量的変動解析に関する検討2009
- Author(s)
  森大、阿部幸平、山口浩明、後藤順一、島田美樹、眞野成康
- Organizer
  第22回バイオメディカル分析科学シンポジウム
- Place of Presentation
  各務原
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] プロテオーム変動解析を目的としたトリプシンを用いる^<18>O一置換法2009
- Author(s)
  森大、阿部幸平、山口浩明、後藤順一、島田美樹、眞野成康
- Organizer
  第34回日本医用マススペクトル学会
- Place of Presentation
  大阪
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] タンパク質変動解析のための^<18>O一置換反応に関する検討2009
- Author(s)
  森大、阿部幸平、山口浩明、後藤順一、島田美樹、眞野成康
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] LC/ESI-MS/MSによる三重抱合型異常胆汁酸の高感度定量法の構築2009
- Author(s)
  三澤靖、外浦亜耶子、阿部幸平、山口浩明、柿山玄太、飯田隆、後藤順一、島田美樹、眞野成康
- Organizer
  第22回バイオメディカル分析科学シンポジウム
- Place of Presentation
  各務原
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] 新規アフィニティー抽出法を用いたラット肝組織中ケノデオキシコール酸結合タンパク質の解析2009
- Author(s)
  三澤靖、佐藤光市、森大、阿部幸平、山口浩明、後藤順一、島田美樹、眞野成康
- Organizer
  第34回日本医用マススペクトル学会
- Place of Presentation
  大阪
- Year and Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] NanoLC/ESI-MS/MSを用いた血清プロテオームの高感度分析に関する検討2008
- Author(s)
  森大、阿部幸平、山口浩明、後藤順一、島田美樹、眞野成康
- Organizer
  第5回東北大学バイオサイエンスシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] 有機アニオントランスポーターOATP4C1によるEstrone-3-sulfateの輸送特性2008
- Author(s)
  杉江美佐、山口浩明、岡田匡弘、阿部高明、後藤順一、菱沼隆則、島田美樹、眞野成康
- Organizer
  第47回日本薬学会東北支部大会
- Place of Presentation
  岩手
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] 医療従事者の抗がん剤暴露調査を目的とするシクロホスファミドの高感度LC/MS/MS分析2008
- Author(s)
  山口浩明、佐藤真美、阿部幸平、菱沼隆則、後藤順一、眞野成康
- Organizer
  第15回クロマトグラフィーシンポジウム
- Place of Presentation
  静岡
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] 脳局在型胆汁酸トランスポーターSLC10A4の機能解析2008
- Author(s)
  山口浩明、岡田匡弘、三日市剛、海野倫明、阿部高明、小野栄夫、大和田祐二、近藤尚武、菱沼隆則、後藤順一、島田美樹、眞野成康
- Organizer
  第5回東北大学バイオサイエンスシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] 腎臓に局在する有機アニオントランスポーターOATP4C1によるエストロン-3-サルフェート輸送2008
- Author(s)
  杉江美佐、山口浩明、岡田匡弘、豊原敬文、種本雅之、阿部高明、後藤順一、菱沼隆則、眞野成康
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] プロテオミクス手法を用いる肝細胞質画分中ケノデオキシコール酸結合タンパク質の解析2008
- Author(s)
  森大、阿部幸平、山口浩明、後藤順一、島田美樹、眞野成康
- Organizer
  第5回東北大学バイオサイエンスシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] NanoLC/ESI-MS/MSによる血清プロテオームの高感度分析のための基盤研究2008
- Author(s)
  森大、阿部幸平、山口浩明、後藤順一、島田美樹、眞野成康
- Organizer
  第21回バイオメディカル分析科学シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-08-08
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] Functional analysis of organic anion transporter, OATP4 Cl, expressed in kidney2008
- Author(s)
  山口浩明
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] プロテオミクス手法を用いる肝細胞質画分中の胆汁酸結合タンパク質の解析2008
- Author(s)
  山口浩明、岡田匡弘、三日市剛、海野倫明、阿部高明、小野栄夫、大和田祐二、近藤尚武、菱沼隆則、後藤順一、島田美樹、眞野成康
- Organizer
  第5回東日本胆汁酸研究会
- Place of Presentation
  東京
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] NanoLC/ESI-MS/MSを用いる血清プロテオーム解析法の構築に関する検討2008
- Author(s)
  森大、阿部幸平、山口浩明、後藤順一、島田美樹、眞野成康
- Organizer
  第48回日本臨床化学会年次学術集会
- Place of Presentation
  浜松
- Year and Date
  2008-08-31
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] 有機アニオントランスポーターOAP1B1及びOATP1B3と相互作用する抗生物質の探索2008
- Author(s)
  竹内俊子、山口浩明、岡田匡弘、阿部高明、菱沼隆則、後藤順一、島田美樹、眞野成康
- Organizer
  第47回日本薬学会東北支部大会
- Place of Presentation
  岩手
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] 脳黒質に発現する胆汁酸トランスポーターの機能解析2008
- Author(s)
  岡田匡弘、山口浩明、三日市剛、海野倫明、阿部高明、小野栄夫、大和田祐二、近藤尚武、菱沼隆則、後藤順一、眞野成康
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] 暴露調査を目的とするシクロホスファミドの高感度LC/MS/MS分析2008
- Author(s)
  佐藤真由美、阿部幸平、山口浩明、菱沼隆則、後藤順一、眞野成康
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] LC/MS/MSを用いたランソプラゾール及びラベプラゾール簡易定量法の構築とその血清中濃度解析2008
- Author(s)
  鈴木香織、菱沼隆則、山口浩明、山岸初志、大原秀一、下瀬川徹、後藤順一、島田美樹、眞野成康
- Organizer
  第21回バイオメディカル分析科学シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-08-08
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] NanoLC/ESI-MS/MSを用いる血清プロテオーム解析法の構築に関する検討2008
- Author(s)
  森大、阿部幸平、山口浩明、後藤順一、島田美樹、眞野成康
- Organizer
  第48回日本臨床化学会年次学術集会
- Place of Presentation
  浜松
- Year and Date
  2008-08-31
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] 有機アニオントランスポーターOATP4C1を介したestrone-3-sulfate輸送2008
- Author(s)
  杉江美佐、山口浩明、岡田匡弘、豊原敬文、種本雅之、阿部高明、後藤順一、菱沼隆則、島田美樹、眞野成康
- Organizer
  第5回東北大学バイオサイエンスシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] NanoLC/ESI-MS/MSによる血清プロテオームの高感度分析のための基盤研究2008
- Author(s)
  山口浩明, 三日市剛, 岡田匡弘, 阿部幸平, 後藤順一, 菱沼隆則, 島田美樹, 眞野成康
- Organizer
  第21回バイオメディカル分析科学シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-08-09
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] 腎臓特異的発現有機アニオントランスポーターOATP4C1の機能解析2008
- Author(s)
  山口浩明, ら
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-08-08
- Data Source
  KAKENHI-PROJECT-20390044
[Presentation] 医療従事者の抗がん剤暴露調査を目的とするシクロホスファミドの高感度LC/MS/MS分析2008
- Author(s)
  山口浩明
- Organizer
  第15回クロマトグラフィーシンポジウム
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] 腎臓特異的発現有機アニオントランスポーターOATP4C1の機能解析2008
- Author(s)
  山口浩明、杉江美佐、岡田匡弘、阿部高明、後藤順一、菱沼隆則、島田美樹、眞野成康
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-08-08
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] NanoLC/ESI-MS/MSによる血清プロテオーム解析の高感度化に関する研究2008
- Author(s)
  森大、阿部幸平、山口浩明、後藤順一、眞野成康
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] 胆汁酸刺激による細胞内プロテオーム変動解析2008
- Author(s)
  眞野成康、阿部幸平、柳澤勇、森大、山口浩明、後藤順一
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] 胆汁酸関連タンパク質のマススペクトロメトリー2008
- Author(s)
  森大、阿部幸平、山口浩明、後藤順一、島田美樹、眞野成康
- Organizer
  第32回医療薬学会公開シンポジウム
- Place of Presentation
  青森
- Year and Date
  2008-11-22
- Data Source
  KAKENHI-PROJECT-20390009
[Presentation] 蛍光プローブを用いたOATP1B3輸送抗がん剤のスクリーニング2008
- Author(s)
  竹内俊子、山口浩明、小林美奈子、岡田匡弘、種本雅之、海野倫明、阿部高明、菱沼隆則、後藤順一、島田美樹、眞野成康
- Organizer
  第5回東北大学バイオサイエンスシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] シロリムスからミコフェノール酸モフェチルに投与変更した膵島移植患者におけるTDM2007
- Author(s)
  松本洋太郎、上西智子、山口浩明、佐藤真由美、小川則彦、後藤昌史、里見進、菱沼隆則、後藤順一、眞野成康
- Organizer
  第17回日本医療薬学会年会
- Place of Presentation
  前橋
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] トランスポーター輸送の可視化に関する研究2007
- Author(s)
  岡田匡弘、山口浩明、小林美奈子、竹内俊子、種本雅之、海野倫明、阿部高明、菱沼隆則、後藤順一、眞野成康
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-11-27
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] パクリタキセルの体内動態に影響を及ぼす薬剤反応性遺伝子多型2007
- Author(s)
  山口浩明、菱沼隆則、遠藤尚美、塚本宏樹、岸川幸生、佐藤真由美、村井ユリ子、平塚真弘、伊藤潔、八重樫伸生、後藤順一、眞野成康
- Organizer
  第1回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  渋谷
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] LC/MS/MSを用いた微量ヒト血清中ランソプラゾール及びラベプラゾール簡易定量法の構築とその臨床応用2007
- Author(s)
  鈴木香織、齋藤昌良、山口浩明、村井ユリ子、山岸初志、小池智幸、大原秀一、下瀬川徹、菱沼隆則、眞野成康、後藤順一
- Organizer
  第18回クロマトグラフィー科学会議
- Place of Presentation
  函館
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] 薬物トランスポーターを機能性器材として活用する薬物治療法の開発2007
- Author(s)
  山口浩明
- Organizer
  日本薬学会東北支部第6回医療薬学若手研究者セミナー
- Place of Presentation
  仙台
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-19790384
[Presentation] カラムスイッチングLC/ESI-MS/MSを用いるミコフェノール酸の血中濃度測定法の構築
- Author(s)
  相馬真志、菊地正史、前川正充、鈴木裕之、久道周彦、山口浩明、島田美樹、眞野成康
- Organizer
  第２４回日本医療薬学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2014-09-27 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] DCF療法における各抗がん薬血中濃度の解析
- Author(s)
  山口浩明
- Organizer
  第４６回医療薬学公開シンポジウム
- Place of Presentation
  にぎわい交流館（秋田県）
- Invited
- Data Source
  KAKENHI-PROJECT-23790168
[Presentation] 医薬品リスク管理計画に関する薬剤師の認識
- Author(s)
  山口浩明、小原拓、佐藤倫広、大久保孝義、村井ユリ子、井関健、眞野成康
- Organizer
  第１７回日本医薬品情報学会総会・学術大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Year and Date
  2014-07-12 – 2014-07-13
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] DCF療法（ドセタキセル、シスプラチン、5‐FU併用療法）における各抗がん薬の血中濃度解析
- Author(s)
  有賀伸、木下一郎、山口浩明、清水康、天野虎次、田口純、本間理央、合田智宏、山田武宏、井関健、秋田弘俊
- Organizer
  第１２回日本臨床腫瘍学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-07-17 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver
- Author(s)
  佐藤紀宏、山口浩明、古川巧馬、阿部高明、眞野成康
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco（USA）
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] EPA由来プロスタグランジン及びトロンボキサンのABCC4を介した細胞外放出
- Author(s)
  田中伸明、山口浩明、眞野成康
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  兵庫医療大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] Identification of the OATP1B3-specific compound LST-02
- Author(s)
  山口浩明、阿部高明、眞野成康
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco（USA）
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460184
[Presentation] トランスポーター機能評価に用いる新規蛍光基質の開発
- Author(s)
  山口浩明、関口穂乃佳、猪俣翔、山岸裕、丸山健一、眞野成康
- Organizer
  第８回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  熊本大学薬学部（熊本県熊本市）
- Year and Date
  2014-11-15 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25460184
[]
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1. MANO Nariyasu (50323035)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
2. 千葉康司 (30458864)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. GOTO Junichi (80006337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
4. SHIMADA Miki (10196488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKAJIMA Akira (20419237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TOMIOKA Yoshihisa (00282062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Shuto Satoshi (70241346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 菱沼隆則 (20199003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 小松康雄 (30271670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 福田隼 (30434450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 有澤光弘 (40312962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 一ノ瀬亘 (00636409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 阿部高明 (80292209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 岡田賢二 (00396673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NODA Masafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. HIRAMA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. KOBAYASHI Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. OGURA Jiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 岡田克典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 佐渡哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 松田安史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 大石久

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 永田美樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 17 results
24. 塚本宏樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 岡本洋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 佐藤紀宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 三枝大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 飯田隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 山本靖彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguti Hiroaki 山口 浩明

山口 浩明 ヤマグチ ヒロアキ

YAMAGUCHI Hiroaki 山口 浩明

Research Projects

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Evidence generation and systematization of drug transfer into breast milk to improve lactation rate in lactating women taking drugsPrincipal Investigator

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The evaluation algorithm of population pharmacokinetics for antimicrobial agent dosage regimen applicable to pediatric

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Participation of OATP4C1 in the pharmacokinetics of drugsPrincipal Investigator

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Medicinal chemistry studies based on the three-dimensional structural diversity-oriented molecular design of pharmacologically active compounds

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Mechanisms of prostanoids release from the cellsPrincipal Investigator

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Characterization of kidney specific organic anion transporter SLCO4C1Principal Investigator

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抗がん剤の体内動態特性に基づいたがん治療効果と副作用に関する研究Principal Investigator

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Proteomics of bile acid signals

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Analysis of functional significance of a newly discovered brain-specific transporter

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新規薬物動態可視化解析法の開発

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Real-time imaging of carrier-mediated transportPrincipal Investigator

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トランスポーターを機能性器材として利用した薬物治療法の開発Principal Investigator

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[Journal Article] The Use of an Antioxidant Enables Accurate Evaluation of the Interaction of Curcumin on Organic Anion-Transporting Polypeptides 4C1 by Preventing Auto-Oxidation2024

Author(s)

Yamaguti Hiroaki 山口浩明

山口浩明ヤマグチヒロアキ

YAMAGUCHI Hiroaki 山口浩明