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Ichimura Yoshinobu  一村 義信

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ICHIMURA Yoshinobu  一村 義信

ICHIMURA Yoshinob  一村 義信

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Researcher Number 80400993
Other IDs
Affiliation (Current) 2025: 順天堂大学, 医学部, 先任准教授
Affiliation (based on the past Project Information) *help 2020 – 2023: 順天堂大学, 医学部, 先任准教授
2015 – 2018: 新潟大学, 医歯学系, 准教授
2012 – 2014: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員
2011: 財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員
2010: 順天堂大学, 東京都臨床医学総合研究所, 主任研究員
2006: Chiba University, Graduate School of Medicine, Research Associate, 大学院医学研究院, 助手
2005: 千葉大学, 大学院・医学研究院, 助手
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related / Basic Section 44010:Cell biology-related / General medical chemistry
Except Principal Investigator
Risk sciences of radiation/Chemicals
Keywords
Principal Investigator
p62 / 選択的オートファジー / リン酸化 / キナーゼ / ホスファターゼ / 脱リン酸化 / ULK1 / p62/SQSTM1 / p62-Keap1-Nrf2経路 / Keap1 … More / p62-Keap1-Nrf2 / Keap1-Nrf2システム / Keap1-Nrf2 system / 液-液相分離 / KEAP1-NRF2 / p62-Nrf2-Keap1 / 前頭側頭骨変性症(FTD) / 筋萎縮性側索硬化症(ALS) / 液滴 / KEAP1-NRF2経路 / ULK1キナーゼ / リン酸化酵素 / NRF2-KEAP1システム / p62-KEAP1-NRF2経路 / Keap1-Nrf2 / p62-Keap1-Nrf2システム / Keap1-Nrf2経路 / Nrf2 / リン酸化p62 / Keap-Nrf2 / がん / p62/Sqstm1 / オートファジー / LC3 … More
Except Principal Investigator
aldolase A / annexin II / GRP78 / 紫外線 / UV (ultraviolet) / human cell / X-ray / autophagy / chaperon / human serum / プロテアーゼ / シャペロン / X線 / annexinII / 放射線 / ヒドロペルオキシド / ヒト細胞 / オートファジー / 2D-DIGE / hsp27 / sensitivity to cell death / ER molecular chaperone / DNA repair / DNA damage / UV / human cells / 遺伝子変異誘導 / 致死感受性 / 小胞体シャペロン / DNA修復 / DNA損傷 / ヒト培養細胞 Less
  • Research Projects

    (7 results)
  • Research Products

    (78 results)
  • Co-Researchers

    (12 People)
  •  リン酸化によるp62の動態調節機構とその生理機能の解明Principal Investigator

    • Principal Investigator
      一村 義信
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Juntendo University
  •  Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress responsePrincipal Investigator

    • Principal Investigator
      Ichimura Yoshinobu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Juntendo University
  •  Study on molecular mechanism of p62-Keap1-Nrf2 systemPrincipal Investigator

    • Principal Investigator
      Ichimura Yoshinobu
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Niigata University
  •  Phosphorylation of p62/Sqstm1 activates Nrf2 during selective autophagyPrincipal Investigator

    • Principal Investigator
      ICHIMURA Yoshinobu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Niigata University
      Tokyo Metropolitan Institute of Medical Science
  •  Molecular mechanisms of p62 degradation in selective autophagyPrincipal Investigator

    • Principal Investigator
      ICHIMURA Yoshinobu
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
      Juntendo University
  •  The study of modulating effects on X-ray induced cell mutability by chaperons and autophagy

    • Principal Investigator
      SUZUKI Nobuo
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Chiba University
  •  Molecular mechanisms of GRP78-involving process to repair UVC-damaged DNA

    • Principal Investigator
      KITA Kazuko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Chiba University

All 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013 2012 2011 2010 2008 2007 2006 Other

All Journal Article Presentation Patent

  • [Journal Article] Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response2023

    • Author(s)
      Ikeda Ryo、Noshiro Daisuke、Morishita Hideaki、Takada Shuhei、Kageyama Shun、Fujioka Yuko、Funakoshi Tomoko、Komatsu‐Hirota Satoko、Arai Ritsuko、Ryzhii Elena、Abe Manabu、Koga Tomoaki、Motohashi Hozumi、Nakao Mitsuyoshi、Sakimura Kenji、Horii Arata、Waguri Satoshi、Ichimura Yoshinobu、Noda Nobuo N、Komatsu Masaaki
    • Journal Title

      The EMBO Journal

      Volume: 42 Issue: 14

    • DOI

      10.15252/embj.2022113349

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K18220, KAKENHI-PROJECT-22K06300, KAKENHI-PROJECT-23K05683, KAKENHI-PROJECT-23K06415, KAKENHI-PROJECT-20KK0185, KAKENHI-ORGANIZER-19H05705, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05264, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-21H04799, KAKENHI-PROJECT-21H02686, KAKENHI-PROJECT-23K27122, KAKENHI-PROJECT-23K27134, KAKENHI-PROJECT-23K27351, KAKENHI-PROJECT-23K27381, KAKENHI-PROJECT-23H05327
  • [Journal Article] Considering the mechanism by which droplets of ALS-FTD-associated SQSTM1/p62 mutants cause pathology2022

    • Author(s)
      Ichimura Y, Komatsu M
    • Journal Title

      Autophagy Reports

      Volume: 1 Issue: 1 Pages: 9-13

    • DOI

      10.1080/27694127.2022.2031380

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06644
  • [Journal Article] A Description of Novel Variants and Review of Phenotypic Spectrum in UBA5-related Early Epileptic Encephalopathy2021

    • Author(s)
      Briere LC, Walker MA, High FA, Rogers CA, Callahan C, Cooper C, Ishimura R, Ichimura Y, Caruso PA, Sharma N, Brokamp E, Koziura ME, Mohammad SS, Dale RC, Riley LG, Network UD, Phillips JA, Komatsu M, Sweetser DA.
    • Journal Title

      Cold Spring Harb Mol Case Stud.

      Volume: mcs Issue: 3 Pages: a005827-a005827

    • DOI

      10.1101/mcs.a005827

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-20K16161, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-16H06276
  • [Journal Article] Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity2021

    • Author(s)
      Faruk MO, Ichimura Y, Kageyama S, Komatsu-Hirota S, El-Gowily AH, Sou YS, Koike M, Noda NN, Komatsu M.
    • Journal Title

      J Biol Chem

      Volume: 297 Issue: 6 Pages: 101405-101405

    • DOI

      10.1016/j.jbc.2021.101405

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07276, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-21H04163, KAKENHI-PROJECT-20K06549, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-20K07743
  • [Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021

    • Author(s)
      Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M.
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 16-16

    • DOI

      10.1038/s41467-020-20185-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-20K06549, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-19K16344, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-20H03415, KAKENHI-PROJECT-16H06276
  • [Journal Article] Selective autophagy2021

    • Author(s)
      Faruk Mohammad Omar、Ichimura Yoshinobu、Komatsu Masaaki
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 10 Pages: 3972-3978

    • DOI

      10.1111/cas.15112

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-16H06276
  • [Journal Article] Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.2018

    • Author(s)
      Ichimura Y, Komatsu M.
    • Journal Title

      Frontiers in Oncology

      Volume: 8 Pages: 210-210

    • DOI

      10.3389/fonc.2018.00210

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05137
  • [Journal Article] Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant.2018

    • Author(s)
      Kageyama Shun、Saito Tetsuya、Obata Miki、Koide Ryouhei、 Ichimura Yoshinobu、Komatsu Masaaki.
    • Journal Title

      Mol Cell Biol.

      Volume: 38 Issue: 7

    • DOI

      10.1128/mcb.00642-17

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H05137
  • [Journal Article] Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.2018

    • Author(s)
      Nahorski MS, Maddirevula S, Ishimura R, Alsahli S, Brady AF, Begemann A, Mizushima T, Guzman-Vega FJ, Obata M, Ichimura Y, Alsaif HS, Anazi S, Ibrahim N, Abdulwahab F, Hashem M, Monies D, Abouelhoda M, Meyer BF, Alfadhel M, Eyaid W, Zweier M, Steindl K, Rauch A, Arold ST, Woods CG, Komatsu M, Alkuraya FS.
    • Journal Title

      Brain

      Volume: 141 Issue: 7 Pages: 1934-1945

    • DOI

      10.1093/brain/awy135

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15061, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-16H06276
  • [Journal Article] p62を介した選択的オートファジー2018

    • Author(s)
      一村義信, 小松雅明
    • Journal Title

      医学のあゆみ

      Volume: 267 Pages: 1023-1028

    • Data Source
      KAKENHI-PROJECT-16H05137
  • [Journal Article] Discovery of benzo[ g ]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor2017

    • Author(s)
      Yasuda Daisuke、Yuasa Akihiro、Obata Rika、Nakajima Mao、Takahashi Kyoko、Ohe Tomoyuki、Ichimura Yoshinobu、Komatsu Masaaki、Yamamoto Masayuki、Imamura Riyo、Kojima Hirotatsu、Okabe Takayoshi、Nagano Tetsuo、Mashino Tadahiko
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 27 Issue: 22 Pages: 5006-5009

    • DOI

      10.1016/j.bmcl.2017.10.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05137
  • [Journal Article] Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.2016

    • Author(s)
      Muona M, Ishimura R, Laari A,...... , Komatsu M.
    • Journal Title

      Am J Hum Genet.

      Volume: 99 Issue: 3 Pages: 683-94

    • DOI

      10.1016/j.ajhg.2016.06.020

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-16J07037, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-15K18373, KAKENHI-PROJECT-26000014
  • [Journal Article] Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.2016

    • Author(s)
      Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V.
    • Journal Title

      J Biol Chem.

      Volume: - Issue: 17 Pages: 9025-9041

    • DOI

      10.1074/jbc.m116.715474

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26650012, KAKENHI-PROJECT-16H05137
  • [Journal Article] Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.2016

    • Author(s)
      Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A.
    • Journal Title

      Elife

      Volume: 20

    • DOI

      10.7554/elife.14810

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-15H04670, KAKENHI-PROJECT-16H05137
  • [Journal Article] Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.2016

    • Author(s)
      Yasuda D, Nakajima M, Yuasa A, Obata R, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 26 Issue: 24 Pages: 5956-5959

    • DOI

      10.1016/j.bmcl.2016.10.083

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05137
  • [Journal Article] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming2016

    • Author(s)
      Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T et al.
    • Journal Title

      Nature Commun

      Volume: 7 Issue: 1 Pages: 12030-12030

    • DOI

      10.1038/ncomms12030

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01190, KAKENHI-PLANNED-24112009, KAKENHI-PLANNED-25111006, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26242088, KAKENHI-PROJECT-26253019, KAKENHI-PROJECT-15H04670, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-16K10565, KAKENHI-PROJECT-15KK0325, KAKENHI-PROJECT-26000014
  • [Journal Article] Regulation of the Keap1-Nrf2 pathway by p62/SQSTM12016

    • Author(s)
      Katsuragi Y, Ichimura Y, Komatsu M.
    • Journal Title

      Curr Opin Toxicol.

      Volume: 1 Pages: 54-61

    • DOI

      10.1016/j.cotox.2016.09.005

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05137
  • [Journal Article] p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.2015

    • Author(s)
      Katsuragi Y, Ichimura Y, Komatsu M.
    • Journal Title

      FEBS J.

      Volume: 282 Issue: 24 Pages: 4672-4678

    • DOI

      10.1111/febs.13540

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26253019, KAKENHI-PROJECT-25460400
  • [Journal Article] Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.2014

    • Author(s)
      Lystad, AH., Ichimura, Y., Takagi, K., Yang, Y., Pankiv, S., Kanegae, Y., Kageyama, S., Suzuki, M., Saito, I., Mizushima,T., *Komatsu, M., *Simonsen, A.
    • Journal Title

      EMBO Rep.

      Volume: 15 Issue: 5 Pages: 557-565

    • DOI

      10.1002/embr.201338003

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631, KAKENHI-PROJECT-26670221, KAKENHI-PROJECT-26860224
  • [Journal Article] 選択的オートファジーと疾患2014

    • Author(s)
      一村義信
    • Journal Title

      Thrombosis Medicine

      Volume: 4 Pages: 215-220

    • Data Source
      KAKENHI-PROJECT-25460400
  • [Journal Article] オートファジーとがん治療2014

    • Author(s)
      一村義信
    • Journal Title

      腫瘍内科

      Volume: 13 Pages: 810-816

    • NAID

      40020137331

    • Data Source
      KAKENHI-PROJECT-25460400
  • [Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy.2014

    • Author(s)
      Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 446 Issue: 1 Pages: 309-315

    • DOI

      10.1016/j.bbrc.2014.02.093

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790332, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-26000014
  • [Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013

    • Author(s)
      Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
    • Journal Title

      Mol Cell

      Volume: 51 Issue: 5 Pages: 618-631

    • DOI

      10.1016/j.molcel.2013.08.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-23247034, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790332, KAKENHI-PROJECT-24790967, KAKENHI-PLANNED-25111002, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631
  • [Journal Article] Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models2012

    • Author(s)
      Ichimura Y, Komatsu M
    • Journal Title

      Exp Anim

      Volume: 60 Pages: 329-345

    • NAID

      10029550484

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590293
  • [Journal Article] Involvement of ubiquitin system in mammalian autophagy2012

    • Author(s)
      Komatsu M, Ichimura Y
    • Journal Title

      生化学

      Volume: 84 Pages: 472-478

    • NAID

      10030809594

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590293
  • [Journal Article] P62/SQSTM1/A170: Physiology and pathology2012

    • Author(s)
      Komatsu M, Kageyama S, Ichimura Y
    • Journal Title

      Pharmacolo Res

      Pages: 457-462

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590293
  • [Journal Article] Crucial role for autophagy in degranulation of mast cells2011

    • Author(s)
      Ushio H, Ueno T, Kojima Y, Komatsu M, Tanaka S, Yamamoto A, Ichimura Y, Ezaki J, Nishida K, Komazawa-Sakon S, Niyonsaba F, Ishii T, Yanagawa T, Kominami E, Ogawa H, Okumura K, Nakano H
    • Journal Title

      J Allergy Clin Immunol

      Pages: 1267-1276

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590293
  • [Journal Article] オートファジーの選択基質p62の生理機能2011

    • Author(s)
      一村義信、小松雅明
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 33 Pages: 371-376

    • NAID

      40019080723

    • Data Source
      KAKENHI-PROJECT-22590293
  • [Journal Article] Pathophysiological role of autophagy : lesson from autophagy-deficient mouse models2011

    • Author(s)
      Ichimura Y, Komatsu M
    • Journal Title

      Exp Anim

      Volume: 60 Pages: 329-345

    • NAID

      10029550484

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590293
  • [Journal Article] オートファジー関連疾患2011

    • Author(s)
      一村義信、小松雅明
    • Journal Title

      SURGERY FRONTIER

      Volume: 18 Pages: 144-151

    • Data Source
      KAKENHI-PROJECT-22590293
  • [Journal Article] Selective degradation of p62 by autophagy.2010

    • Author(s)
      Ichimura Yoshinobu
    • Journal Title

      Seminars in immunopathology.

      Volume: 32 Pages: 431-436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590293
  • [Journal Article] Down-regulation of Molecular Chaperone GRP78/Bip Expression Involved in Enhancement of Human RS Cell Mutability.2008

    • Author(s)
      Hirano J., Kita K., Sugaya S., Ichimura Y., Yamamori H., Nakajima N., Suzuki, N.
    • Journal Title

      Pancreas 36

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Down-regulation of Molecular Chaperone CRP78/Bip Expression Involved in Enhancement of Human RS Cell Mutability2008

    • Author(s)
      Hirano J., Kita K., Sugaya S., Ichimura Y., Yamamori H., Nakajima N., Suzuki, N
    • Journal Title

      Pancreas 36(1)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Down-regulation of Molecular Chaperone GRP78/Bip Expression Involved in Enhanoement of Human RS Cell Mutability2008

    • Author(s)
      Hirano J., Kita K., Sugaya S., Ichimura Y., Yamamori H., Nakajima N., Suzuki, N.
    • Journal Title

      Pancreas 36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Modulation of mutability in UV-irradiated human RSb cells by serum obtained from parabolic flight volunteers2007

    • Author(s)
      Chi Xiao-Jun Takahashi S., Nomura J., Sugaya S., Ichimura Y., Zhai L, Tong X., Kita K., Suzuki N.
    • Journal Title

      J.Int.Society of Life Information Science 25

      Pages: 11-12

    • NAID

      110006242228

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Modulation of mutability in UV-irradiated human RSb cells by serum obtained from parabolic flight volunteers2007

    • Author(s)
      Chi Xiao-Jun, Takahashi S., Nomura J., Sugaya S., Ichimura Y., Zhai L., Tong X., Kita K, Suzuki N.
    • Journal Title

      Journal of International Society of Life Information Science 25

      Pages: 11-22

    • NAID

      110006242228

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Modulation of mutability in UV-irradiated human RSb cells by serum obtained from parabolic flight volunteers.2007

    • Author(s)
      Chi Xiao Jun, Takahashi S., Nomura J., Sugaya S., Ichimura Y., Zhai L., Tong X., Kita K., Suzuki N.
    • Journal Title

      J. Int. Society of Life Information Science. 25

      Pages: 11-12

    • NAID

      110006242228

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Life Science of Gravity-changing Stress; Modulation of UV-mutagenicity in human RSb Cells by Serum Factors from Volunteers Who Experienced Parabolic Flight2006

    • Author(s)
      Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S., Ichimura, Y., Zhai, L., Tong, X., Kita, K.
    • Journal Title

      J. Intl. Soc. Life Info. Sci 24(2)

      Pages: 362-363

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Life science of gravity-changing stress ; modulaiton of UV-mutagenicity in human RSb cells by serum factors from volunteers who experienced parabolic flight.2006

    • Author(s)
      Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S., Ichimura, Y., Zhai, L., Tong, X., Kita, K.
    • Journal Title

      J.Int.Soc.Life Info.Sci. 24

      Pages: 362-363

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17510040
  • [Journal Article] Life Science of Gravity-changing Stress; Modulation of UV-mutagenicity in human RSb Cells by Serum Factors from Volunteers Who Experienced Parabolic Flight.2006

    • Author(s)
      Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S, Ichimura, Y., Zhai, L., Tong, X., Kita, K.
    • Journal Title

      J. Intl. Soc. Life Info. Sci. 24・2

      Pages: 362-363

    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Crystallization and preliminary X-ray analysis of Atg3.2006

    • Author(s)
      Yamada Y, Suzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F.
    • Journal Title

      Acta.Crystallograph.Sect.F.Struct.Biol.Cryst.Commun. 62

      Pages: 1016-1017

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17510040
  • [Journal Article] Crystallization and preliminary X-ray and analysis of Atg3.2006

    • Author(s)
      Yamada Y, Suzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F
    • Journal Title

      Acta Crystallograph Sect F Struct Biol Cryst Commun. 62

      Pages: 1016-1017

    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Life Science of Gravity-changing Stress; Modulation of UV-mutagenicity in human RSb Cells by Serum Factors from Volunteers Who Experienced Parabolic Flight.2006

    • Author(s)
      Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S., Ichimura, Y., Zhai, L., Tong, X., Kita, K.
    • Journal Title

      J. Intl. Soc. Life Info. Sci. 24

      Pages: 362-363

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy.2006

    • Author(s)
      Amar N, Lustig G, Ichimura Y, Ohsumi Y, Elazar Z
    • Journal Title

      EMBO Rep. 7

      Pages: 635-642

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17510040
  • [Journal Article] Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy.2006

    • Author(s)
      Amar N, Lustig G, Ichimura Y, Ohsumi Y, Elazar Z.
    • Journal Title

      EMBO Rep. 7

      Pages: 635-642

    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Crystallization and preliminary X-ray analysis of Atg3.2006

    • Author(s)
      Yamada Y, Suzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F
    • Journal Title

      Acta. Crystallograph. Sect. F. Struct. Biol. Cryst. Commun. 62

      Pages: 1016-1017

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17510040
  • [Journal Article] Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy.2006

    • Author(s)
      Amar N, Lustig G, Ichimura Y, Ohsumi Y, Elazar Z.
    • Journal Title

      EMBO Rep. 7

      Pages: 635-642

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17510040
  • [Journal Article] Life science of gravity-changing stress; modulation of UV-mutagenicity in human RSb cells by serum factors from volunteers who experienced parabolic flight.2006

    • Author(s)
      Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S., Ichimura, Y., Zhai, L., Tong, X., Kita,K.
    • Journal Title

      J.Int.Soc.Life Info.Sci. 24,2

      Pages: 362-363

    • Data Source
      KAKENHI-PROJECT-17510040
  • [Journal Article] Life science of gravity-changing stress; modulation of UV- mutagenicity in human RSb cells by serum factors from volunteers who experienced parabolic flight.2006

    • Author(s)
      Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S., Ichimura, Y., Zhai, L., Tong, X., Kita, K.
    • Journal Title

      J. Int. Soc. Life Info. Sci. 24, 2

      Pages: 362-363

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17510040
  • [Journal Article] Crystallization and preliminary X-ray analysis of Atg3.2006

    • Author(s)
      Yamada Y, Zuzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F.
    • Journal Title

      Acta.Crystallograph.Sect.F.Struct.Biol.Cryst.Commun. 62

      Pages: 1016-1017

    • Data Source
      KAKENHI-PROJECT-17510040
  • [Journal Article] Modulation of mutability in UV-irradiated human RSb cells by serum obtained from parabolic flight volunteers

    • Author(s)
      Chi Xiao-Jun, Takahashi S., Nomura J., Sugaya S., Ichimura Y., Zhai L., Tong X., Kita K., Suzuki N.
    • Journal Title

      Journal of International Society of Life Information Science (In press)

    • NAID

      110006242228

    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Annexin II a novel HSP27-interacted protein, is involved in resistance to UVC-induced cell death in human AP^r-1 cells

    • Author(s)
      Tong, X., Kita, K., Karata, K., Zhu, C., Sugaya, S., Ichimura Y, Satoh, M., Tomonaga, T., Nomura, F., Jin, Y, Suzuki, N.
    • Journal Title

      Photochem. Photobiol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Annexin II,a novel HSP27-interacted protein,is involved in resistance to UVC-induced cell death in human AP-1 cells

    • Author(s)
      Tong, X., Kita, K., Karata, K., Zhu, C., Sugaya, S., Ichimura Y., Satoh, M., Tomonaga, T., Nomura, F., Jin, Y., Suzuki, N.
    • Journal Title

      Photochem.Photobiol (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Journal Article] Annexin II, a novel HSP27-interacted protein, is involved in resistance to UVC-induced cell death in human AP^r-1 cells.

    • Author(s)
      Tong, X., Kita, K., Karata, K., Zhu, C., Sugaya, S., Ichimura Y., Satoh, M., Tomonaga, T., Nomura, F., Jin, Y., Suzuki, N.
    • Journal Title

      Photochem. Photobiol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Patent] Reagent for diagnosing tumor, pharmaceutical composition, and screening method2013

    • Inventor(s)
      Komatsu M, Ichimura Y
    • Industrial Property Rights Holder
      Komatsu M, Ichimura Y
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-06-05
    • Acquisition Date
      2015-07-28
    • Overseas
    • Data Source
      KAKENHI-PROJECT-25460400
  • [Presentation] ULK1 によるp62 液滴のリン酸化は、レドックス非依存的なストレス応答を制御する2023

    • Author(s)
      一村義信、池田良、能代大輔、森下英晃、高田周平、蔭山俊、藤岡優子、船越智子、小松(廣田)聡子、荒井律子、Elena Ryzhii、阿部学、古賀友紹、中尾光善、﨑村建司、堀井新、和栗聡、野田展生、小松雅明
    • Organizer
      第75回日本細胞生物学会大会
    • Data Source
      KAKENHI-PROJECT-23K06415
  • [Presentation] 相分離したp62液滴のULK1によるリン酸化は酸化還元非依存的なストレス応答を活性化する2023

    • Author(s)
      一村義信、池田良、能代大輔、森下英晃、高田周平、蔭山俊、藤岡優子、船越智子、小松(廣田)聡子、荒井律子、Elena Ryzhii、阿部学、古賀友紹、本橋ほづみ、中尾光善、﨑村建司、堀井新、和栗聡、野田展生、小松雅明
    • Organizer
      第5回「マルチモードオートファジー」班会議・第15回 オートファジー研究会
    • Data Source
      KAKENHI-PROJECT-23K06415
  • [Presentation] 相分離したp62液滴のULK1によるリン酸化は酸化還元非依存的なストレス応答を活性化する2023

    • Author(s)
      一村義信、池田良、能代大輔、森下英晃、高田周平、蔭山俊、藤岡優子、船越智子、小松(廣田)聡子、荒井律子、Elena Ryzhii、阿部学、古賀友紹、本橋ほづみ、中尾光善、﨑村建司、堀井新、和栗聡、野田展生、小松雅明
    • Organizer
      第96回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-23K06415
  • [Presentation] ULK1によるp62液―液相分離制御2022

    • Author(s)
      一村 義信、池田 良、森下 英晃、能代 大輔、野田 展生、小松 雅明
    • Organizer
      日本Cell Death学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K06644
  • [Presentation] ULK1/2-mediated p62-phosphorylation at Ser349 is physiologically important for NRF2 activation2022

    • Author(s)
      Ryo Ikeda, ○Yoshinobu Ichimura, Daisuke Noshiro, Hideaki Morishita, Shuhei Takada, Tomoko Funakoshi, Satoko Komatsu-Hirota, Shun Kageyama, Ritsuko Arai, Manabu Abe, Kenji Sakimura, Arata Horii, Satoshi Waguri, Nobuo N Noda, and Masaaki Komatsu
    • Organizer
      The 10th International Symposium on Autophagy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06644
  • [Presentation] p62脱リン酸化酵素の同定2020

    • Author(s)
      池田良、一村義信、小松聡子、小松雅明
    • Organizer
      オートファジー研究会
    • Data Source
      KAKENHI-PROJECT-20K06644
  • [Presentation] リン酸化p62を指標とするオートファジーFlux assay2018

    • Author(s)
      一村義信、Omar Faruk、小幡美貴、小松雅明
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H05137
  • [Presentation] リン酸化p62抗体を利用したオートファジーフラックスアッセイ2018

    • Author(s)
      一村義信、Omar Faruk、小幡美貴、小松雅明
    • Organizer
      第11回オートファジー研究会
    • Data Source
      KAKENHI-PROJECT-16H05137
  • [Presentation] High-throughput screening for inhibitors of p62-Keap1 protein-protein interaction2017

    • Author(s)
      Yoshinobu Ichimura, Tetsuya Saito, Masaaki Komatsu
    • Organizer
      The 8th International Symposium on Autophagy (ISA)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05137
  • [Presentation] p62/Sqstm1のKeap1相互作用領域をリン酸化するキナーゼのスクリーニング2016

    • Author(s)
      一村義信、小松雅明
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター、東北大学川内北キャンパス(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-16H05137
  • [Presentation] 肝臓がんを抑制する新規化合物K67の同定とその作用機序2016

    • Author(s)
      一村義信
    • Organizer
      第4回創薬等支援技術基盤プラットフォーム公開シンポジウム
    • Place of Presentation
      有楽町朝日ホール(東京都千代田区)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05137
  • [Presentation] リン酸化p62とKEAP1の結合を特異的に阻害する化合物K67の抗がん作用2016

    • Author(s)
      一村義信、斉藤哲也、小松雅明
    • Organizer
      第10回オートファジー研究会・第4回新学術「オートファジー」班会議
    • Place of Presentation
      NASPA ニューオータニ (新潟県南魚沼郡湯沢町)
    • Year and Date
      2016-11-13
    • Data Source
      KAKENHI-PROJECT-16H05137
  • [Presentation] Screening of a Responsible Kinase(s) for p62/SQSTM1, an Autophagy-specific Substrate2015

    • Author(s)
      Yoshinobu Ichimura
    • Organizer
      Symposium on Autophagy (A3)
    • Place of Presentation
      Yonsei University, Seoul, Korea
    • Year and Date
      2015-10-29
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460400
  • [Presentation] オートファジーとKeap1-Nrf2システムの連動2013

    • Author(s)
      一村義信
    • Organizer
      新学術領域「オートファジーの集学的研究:分子基盤から疾患まで」第1回班会議
    • Place of Presentation
      静岡県掛川市 ヤマハリゾート「つま恋」
    • Data Source
      KAKENHI-PROJECT-25460400
  • [Presentation] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy2013

    • Author(s)
      一村義信
    • Organizer
      第5回 医学研国際シンポジウム
    • Place of Presentation
      東京都医学総合研究所
    • Invited
    • Data Source
      KAKENHI-PROJECT-25460400
  • [Presentation] オートファジーとKeap1-Nrf2システムの接点:その異常と腫瘍増殖2013

    • Author(s)
      一村義信
    • Organizer
      第1回 がんと代謝研究会
    • Place of Presentation
      慶應義塾大学先端生命科学研究所
    • Data Source
      KAKENHI-PROJECT-25460400
  • [Presentation] Phosphorylation of p62 robustly activates Nrf2 and contributes to tumor development2012

    • Author(s)
      一村義信
    • Organizer
      The 6th International Symposium on Autophagy
    • Place of Presentation
      沖縄
    • Data Source
      KAKENHI-PROJECT-22590293
  • [Presentation] Molecular mechanism of p62 turnover by constitutive autophagy2011

    • Author(s)
      一村義信
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-22590293
  • [Presentation] Molecular mechanism of p62 degradation in selective autophagy2010

    • Author(s)
      一村義信
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-22590293
  • [Presentation] HSP27 and its interacted protein,is inrvolved in susoeptibility to radiation Iethality in human cells2007

    • Author(s)
      Tong Xiao bo, Kita K., Karata K, Zhu C., Sugaya S., Ichimura Y., Sato M., Tomonaga T., Nomura F., Jin Y-H, . Suzuki N.
    • Organizer
      Keystone Sylmposia on Melecular and cellular Bielogy, GastOiiitestinal Canoer(T2)
    • Place of Presentation
      Beijng,China
    • Year and Date
      2007-10-17
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Presentation] HSP27and its interacted protein, is involved in susceptibility to radiation lethality in human cells.2007

    • Author(s)
      Tong Xiao bo, Kita K., Karata K., Zhu C., Sugaya S., Ichimura Y., Sato M., Tomonaga T., Nomura F., Jin Y-H., Suzuki N.
    • Organizer
      Keystone Symposia on Molecular and cellular Biology, Gastointestinal Cancer (T2)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2007-10-17
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Presentation] HSP27 and its interacted protein, is involved in susceptibility to radiation lethality in human cells2007

    • Author(s)
      Tong Xiao bo, Kita K., Karata K, Zhu C., Sugaya S., Ichimura Y., Sato M., Tomonaga T., Nomura F., Jin Y-H,. Suzuki N.
    • Organizer
      Keystone Symposia on Molecular and cellular Biology, Gastointestinal Cancer (T2)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2007-10-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18510041
  • [Presentation] p62のリン酸化を介した選択的オートファジーとKeap1-Nrf2システムの連動

    • Author(s)
      一村義信、蔭山俊、和栗聡、水島恒裕、本橋ほづみ、山本雅之、小松雅明
    • Organizer
      新学術領域「オートファジーの集学的研究:分子基盤から疾患まで」第2回班会議・第8回オートファジー研究会
    • Place of Presentation
      「シャトレーゼ ガトーキングダム サッポロ」北海道札幌市
    • Year and Date
      2014-11-10 – 2014-11-11
    • Data Source
      KAKENHI-PROJECT-25460400
  • 1.  KOMATSU Masaaki (90356254)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 15 results
  • 2.  KITA Kazuko (80302545)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 19 results
  • 3.  SUZUKI Toshikazu (70270527)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 22 results
  • 4.  SUZUKI Nobuo (90111426)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
  • 5.  SUGAYA Shigeru (90334177)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 16 results
  • 6.  TAGUCHI Keiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  KOGA Tomoaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  曽 友深
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 9.  和栗 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  山本 雅之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  石村 亮輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  田中 啓二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

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