Ichimura Yoshinobu 一村義信

… Alternative Names

ICHIMURA Yoshinobu 一村義信

ICHIMURA Yoshinob 一村義信

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Researcher Number	80400993
Other IDs
Affiliation (Current)	2024: 順天堂大学, 医学部, 先任准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 順天堂大学, 医学部, 先任准教授 2015 – 2018: 新潟大学, 医歯学系, 准教授 2012 – 2014: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 2011: 財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員 2010: 順天堂大学, 東京都臨床医学総合研究所, 主任研究員 2006: Chiba University, Graduate School of Medicine, Research Associate, 大学院医学研究院, 助手 2005: 千葉大学, 大学院・医学研究院, 助手
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related / Basic Section 44010:Cell biology-related / General medical chemistry Except Principal Investigator Risk sciences of radiation/Chemicals
Keywords	Principal Investigator p62 / 選択的オートファジー / キナーゼ / リン酸化 / ホスファターゼ / p62/SQSTM1 / p62-Keap1-Nrf2経路 / Keap1 / p62-Keap1-Nrf2 / Keap1-Nrf2システム … More / Keap1-Nrf2 system / 脱リン酸化 / p62-Nrf2-Keap1 / 前頭側頭骨変性症（FTD） / 筋萎縮性側索硬化症(ALS) / 液滴 / KEAP1-NRF2経路 / ULK1キナーゼ / リン酸化酵素 / NRF2-KEAP1システム / p62-KEAP1-NRF2経路 / ULK1 / Keap1-Nrf2 / p62-Keap1-Nrf2システム / Keap1-Nrf2経路 / Nrf2 / リン酸化p62 / Keap-Nrf2 / がん / p62/Sqstm1 / オートファジー / LC3 … More Except Principal Investigator aldolase A / annexin II / GRP78 / 紫外線 / UV (ultraviolet) / human cell / X-ray / autophagy / chaperon / human serum / プロテアーゼ / シャペロン / X線 / annexinII / 放射線 / ヒドロペルオキシド / ヒト細胞 / オートファジー / 2D-DIGE / hsp27 / sensitivity to cell death / ER molecular chaperone / DNA repair / DNA damage / UV / human cells / 遺伝子変異誘導 / 致死感受性 / 小胞体シャペロン / DNA修復 / DNA損傷 / ヒト培養細胞 Less

リン酸化によるp62の動態調節機構とその生理機能の解明Principal Investigator
- Principal Investigator
  
  一村義信
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress responsePrincipal Investigator
- Principal Investigator
  
  Ichimura Yoshinobu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Juntendo University
Study on molecular mechanism of p62-Keap1-Nrf2 systemPrincipal Investigator
- Principal Investigator
  
  Ichimura Yoshinobu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Niigata University
Phosphorylation of p62/Sqstm1 activates Nrf2 during selective autophagyPrincipal Investigator
- Principal Investigator
  
  ICHIMURA Yoshinobu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Niigata University
  Tokyo Metropolitan Institute of Medical Science
Molecular mechanisms of p62 degradation in selective autophagyPrincipal Investigator
- Principal Investigator
  
  ICHIMURA Yoshinobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
  Juntendo University
The study of modulating effects on X-ray induced cell mutability by chaperons and autophagy
- Principal Investigator
  
  SUZUKI Nobuo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Chiba University
Molecular mechanisms of GRP78-involving process to repair UVC-damaged DNA
- Principal Investigator
  
  KITA Kazuko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Chiba University

[Journal Article] Considering the mechanism by which droplets of ALS-FTD-associated SQSTM1/p62 mutants cause pathology2022
- Author(s)
  Ichimura Y, Komatsu M
- Journal Title
  
  Autophagy Reports
  
  Volume: 1 Issue: 1 Pages: 9-13
- DOI
  10.1080/27694127.2022.2031380
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06644
[Journal Article] A Description of Novel Variants and Review of Phenotypic Spectrum in UBA5-related Early Epileptic Encephalopathy2021
- Author(s)
  Briere LC, Walker MA, High FA, Rogers CA, Callahan C, Cooper C, Ishimura R, Ichimura Y, Caruso PA, Sharma N, Brokamp E, Koziura ME, Mohammad SS, Dale RC, Riley LG, Network UD, Phillips JA, Komatsu M, Sweetser DA.
- Journal Title
  
  Cold Spring Harb Mol Case Stud.
  
  Volume: mcs Issue: 3 Pages: a005827-a005827
- DOI
  10.1101/mcs.a005827
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-20K16161, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-16H06276
[Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021
- Author(s)
  Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 16-16
- DOI
  10.1038/s41467-020-20185-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-20K06549, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-19K16344, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-20H03415, KAKENHI-PROJECT-16H06276
[Journal Article] Selective autophagy2021
- Author(s)
  Faruk Mohammad Omar、Ichimura Yoshinobu、Komatsu Masaaki
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 3972-3978
- DOI
  10.1111/cas.15112
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-16H06276
[Journal Article] Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity2021
- Author(s)
  Faruk MO, Ichimura Y, Kageyama S, Komatsu-Hirota S, El-Gowily AH, Sou YS, Koike M, Noda NN, Komatsu M.
- Journal Title
  
  J Biol Chem
  
  Volume: 297 Issue: 6 Pages: 101405-101405
- DOI
  10.1016/j.jbc.2021.101405
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07276, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-21H04163, KAKENHI-PROJECT-20K06549, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-20K07743
[Journal Article] Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant.2018
- Author(s)
  Kageyama Shun、Saito Tetsuya、Obata Miki、Koide Ryouhei、 Ichimura Yoshinobu、Komatsu Masaaki.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 38 Issue: 7
- DOI
  10.1128/mcb.00642-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H05137
[Journal Article] Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.2018
- Author(s)
  Ichimura Y, Komatsu M.
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 8 Pages: 210-210
- DOI
  10.3389/fonc.2018.00210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05137
[Journal Article] Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.2018
- Author(s)
  Nahorski MS, Maddirevula S, Ishimura R, Alsahli S, Brady AF, Begemann A, Mizushima T, Guzman-Vega FJ, Obata M, Ichimura Y, Alsaif HS, Anazi S, Ibrahim N, Abdulwahab F, Hashem M, Monies D, Abouelhoda M, Meyer BF, Alfadhel M, Eyaid W, Zweier M, Steindl K, Rauch A, Arold ST, Woods CG, Komatsu M, Alkuraya FS.
- Journal Title
  
  Brain
  
  Volume: 141 Issue: 7 Pages: 1934-1945
- DOI
  10.1093/brain/awy135
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15061, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-16H06276
[Journal Article] p62を介した選択的オートファジー2018
- Author(s)
  一村義信, 小松雅明
- Journal Title
  
  医学のあゆみ
  
  Volume: 267 Pages: 1023-1028
- Data Source
  KAKENHI-PROJECT-16H05137
[Journal Article] Discovery of benzo[ g ]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor2017
- Author(s)
  Yasuda Daisuke、Yuasa Akihiro、Obata Rika、Nakajima Mao、Takahashi Kyoko、Ohe Tomoyuki、Ichimura Yoshinobu、Komatsu Masaaki、Yamamoto Masayuki、Imamura Riyo、Kojima Hirotatsu、Okabe Takayoshi、Nagano Tetsuo、Mashino Tadahiko
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 27 Issue: 22 Pages: 5006-5009
- DOI
  10.1016/j.bmcl.2017.10.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05137
[Journal Article] Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.2016
- Author(s)
  Yasuda D, Nakajima M, Yuasa A, Obata R, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 26 Issue: 24 Pages: 5956-5959
- DOI
  10.1016/j.bmcl.2016.10.083
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05137
[Journal Article] Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.2016
- Author(s)
  Muona M, Ishimura R, Laari A,...... , Komatsu M.
- Journal Title
  
  Am J Hum Genet.
  
  Volume: 99 Issue: 3 Pages: 683-94
- DOI
  10.1016/j.ajhg.2016.06.020
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-16J07037, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-15K18373, KAKENHI-PROJECT-26000014
[Journal Article] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming2016
- Author(s)
  Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T et al.
- Journal Title
  
  Nature Commun
  
  Volume: 7 Issue: 1 Pages: 12030-12030
- DOI
  10.1038/ncomms12030
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01190, KAKENHI-PLANNED-24112009, KAKENHI-PLANNED-25111006, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26242088, KAKENHI-PROJECT-26253019, KAKENHI-PROJECT-15H04670, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-16K10565, KAKENHI-PROJECT-15KK0325, KAKENHI-PROJECT-26000014
[Journal Article] Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.2016
- Author(s)
  Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V.
- Journal Title
  
  J Biol Chem.
  
  Volume: - Issue: 17 Pages: 9025-9041
- DOI
  10.1074/jbc.m116.715474
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26650012, KAKENHI-PROJECT-16H05137
[Journal Article] Regulation of the Keap1-Nrf2 pathway by p62/SQSTM12016
- Author(s)
  Katsuragi Y, Ichimura Y, Komatsu M.
- Journal Title
  
  Curr Opin Toxicol.
  
  Volume: 1 Pages: 54-61
- DOI
  10.1016/j.cotox.2016.09.005
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05137
[Journal Article] Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.2016
- Author(s)
  Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A.
- Journal Title
  
  Elife
  
  Volume: 20
- DOI
  10.7554/elife.14810
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-15H04670, KAKENHI-PROJECT-16H05137
[Journal Article] p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.2015
- Author(s)
  Katsuragi Y, Ichimura Y, Komatsu M.
- Journal Title
  
  FEBS J.
  
  Volume: 282 Issue: 24 Pages: 4672-4678
- DOI
  10.1111/febs.13540
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26253019, KAKENHI-PROJECT-25460400
[Journal Article] オートファジーとがん治療2014
- Author(s)
  一村義信
- Journal Title
  
  腫瘍内科
  
  Volume: 13 Pages: 810-816
- NAID
  40020137331
- Data Source
  KAKENHI-PROJECT-25460400
[Journal Article] Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.2014
- Author(s)
  Lystad, AH., Ichimura, Y., Takagi, K., Yang, Y., Pankiv, S., Kanegae, Y., Kageyama, S., Suzuki, M., Saito, I., Mizushima,T., *Komatsu, M., *Simonsen, A.
- Journal Title
  
  EMBO Rep.
  
  Volume: 15 Issue: 5 Pages: 557-565
- DOI
  10.1002/embr.201338003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631, KAKENHI-PROJECT-26670221, KAKENHI-PROJECT-26860224
[Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy.2014
- Author(s)
  Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 446 Issue: 1 Pages: 309-315
- DOI
  10.1016/j.bbrc.2014.02.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790332, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-26000014
[Journal Article] 選択的オートファジーと疾患2014
- Author(s)
  一村義信
- Journal Title
  
  Thrombosis Medicine
  
  Volume: 4 Pages: 215-220
- Data Source
  KAKENHI-PROJECT-25460400
[Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013
- Author(s)
  Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
- Journal Title
  
  Mol Cell
  
  Volume: 51 Issue: 5 Pages: 618-631
- DOI
  10.1016/j.molcel.2013.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-23247034, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790332, KAKENHI-PROJECT-24790967, KAKENHI-PLANNED-25111002, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631
[Journal Article] Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models2012
- Author(s)
  Ichimura Y, Komatsu M
- Journal Title
  
  Exp Anim
  
  Volume: 60 Pages: 329-345
- NAID
  10029550484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590293
[Journal Article] P62/SQSTM1/A170: Physiology and pathology2012
- Author(s)
  Komatsu M, Kageyama S, Ichimura Y
- Journal Title
  
  Pharmacolo Res
  
  Pages: 457-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590293
[Journal Article] Involvement of ubiquitin system in mammalian autophagy2012
- Author(s)
  Komatsu M, Ichimura Y
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 472-478
- NAID
  10030809594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590293
[Journal Article] Crucial role for autophagy in degranulation of mast cells2011
- Author(s)
  Ushio H, Ueno T, Kojima Y, Komatsu M, Tanaka S, Yamamoto A, Ichimura Y, Ezaki J, Nishida K, Komazawa-Sakon S, Niyonsaba F, Ishii T, Yanagawa T, Kominami E, Ogawa H, Okumura K, Nakano H
- Journal Title
  
  J Allergy Clin Immunol
  
  Pages: 1267-1276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590293
[Journal Article] オートファジーの選択基質p62の生理機能2011
- Author(s)
  一村義信、小松雅明
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 33 Pages: 371-376
- NAID
  40019080723
- Data Source
  KAKENHI-PROJECT-22590293
[Journal Article] オートファジー関連疾患2011
- Author(s)
  一村義信、小松雅明
- Journal Title
  
  SURGERY FRONTIER
  
  Volume: 18 Pages: 144-151
- Data Source
  KAKENHI-PROJECT-22590293
[Journal Article] Pathophysiological role of autophagy : lesson from autophagy-deficient mouse models2011
- Author(s)
  Ichimura Y, Komatsu M
- Journal Title
  
  Exp Anim
  
  Volume: 60 Pages: 329-345
- NAID
  10029550484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590293
[Journal Article] Selective degradation of p62 by autophagy.2010
- Author(s)
  Ichimura Yoshinobu
- Journal Title
  
  Seminars in immunopathology.
  
  Volume: 32 Pages: 431-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590293
[Journal Article] Down-regulation of Molecular Chaperone GRP78/Bip Expression Involved in Enhancement of Human RS Cell Mutability.2008
- Author(s)
  Hirano J., Kita K., Sugaya S., Ichimura Y., Yamamori H., Nakajima N., Suzuki, N.
- Journal Title
  
  Pancreas 36
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Down-regulation of Molecular Chaperone CRP78/Bip Expression Involved in Enhancement of Human RS Cell Mutability2008
- Author(s)
  Hirano J., Kita K., Sugaya S., Ichimura Y., Yamamori H., Nakajima N., Suzuki, N
- Journal Title
  
  Pancreas 36(1)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Down-regulation of Molecular Chaperone GRP78/Bip Expression Involved in Enhanoement of Human RS Cell Mutability2008
- Author(s)
  Hirano J., Kita K., Sugaya S., Ichimura Y., Yamamori H., Nakajima N., Suzuki, N.
- Journal Title
  
  Pancreas 36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Modulation of mutability in UV-irradiated human RSb cells by serum obtained from parabolic flight volunteers.2007
- Author(s)
  Chi Xiao Jun, Takahashi S., Nomura J., Sugaya S., Ichimura Y., Zhai L., Tong X., Kita K., Suzuki N.
- Journal Title
  
  J. Int. Society of Life Information Science. 25
  
  Pages: 11-12
- NAID
  110006242228
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Modulation of mutability in UV-irradiated human RSb cells by serum obtained from parabolic flight volunteers2007
- Author(s)
  Chi Xiao-Jun, Takahashi S., Nomura J., Sugaya S., Ichimura Y., Zhai L., Tong X., Kita K, Suzuki N.
- Journal Title
  
  Journal of International Society of Life Information Science 25
  
  Pages: 11-22
- NAID
  110006242228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Modulation of mutability in UV-irradiated human RSb cells by serum obtained from parabolic flight volunteers2007
- Author(s)
  Chi Xiao-Jun Takahashi S., Nomura J., Sugaya S., Ichimura Y., Zhai L, Tong X., Kita K., Suzuki N.
- Journal Title
  
  J.Int.Society of Life Information Science 25
  
  Pages: 11-12
- NAID
  110006242228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Crystallization and preliminary X-ray and analysis of Atg3.2006
- Author(s)
  Yamada Y, Suzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F
- Journal Title
  
  Acta Crystallograph Sect F Struct Biol Cryst Commun. 62
  
  Pages: 1016-1017
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Life Science of Gravity-changing Stress; Modulation of UV-mutagenicity in human RSb Cells by Serum Factors from Volunteers Who Experienced Parabolic Flight.2006
- Author(s)
  Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S., Ichimura, Y., Zhai, L., Tong, X., Kita, K.
- Journal Title
  
  J. Intl. Soc. Life Info. Sci. 24
  
  Pages: 362-363
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy.2006
- Author(s)
  Amar N, Lustig G, Ichimura Y, Ohsumi Y, Elazar Z
- Journal Title
  
  EMBO Rep. 7
  
  Pages: 635-642
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510040
[Journal Article] Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy.2006
- Author(s)
  Amar N, Lustig G, Ichimura Y, Ohsumi Y, Elazar Z.
- Journal Title
  
  EMBO Rep. 7
  
  Pages: 635-642
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Crystallization and preliminary X-ray analysis of Atg3.2006
- Author(s)
  Yamada Y, Suzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F
- Journal Title
  
  Acta. Crystallograph. Sect. F. Struct. Biol. Cryst. Commun. 62
  
  Pages: 1016-1017
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510040
[Journal Article] Life science of gravity-changing stress; modulation of UV- mutagenicity in human RSb cells by serum factors from volunteers who experienced parabolic flight.2006
- Author(s)
  Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S., Ichimura, Y., Zhai, L., Tong, X., Kita, K.
- Journal Title
  
  J. Int. Soc. Life Info. Sci. 24, 2
  
  Pages: 362-363
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510040
[Journal Article] Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy.2006
- Author(s)
  Amar N, Lustig G, Ichimura Y, Ohsumi Y, Elazar Z.
- Journal Title
  
  EMBO Rep. 7
  
  Pages: 635-642
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510040
[Journal Article] Life Science of Gravity-changing Stress; Modulation of UV-mutagenicity in human RSb Cells by Serum Factors from Volunteers Who Experienced Parabolic Flight2006
- Author(s)
  Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S., Ichimura, Y., Zhai, L., Tong, X., Kita, K.
- Journal Title
  
  J. Intl. Soc. Life Info. Sci 24(2)
  
  Pages: 362-363
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Life science of gravity-changing stress; modulation of UV-mutagenicity in human RSb cells by serum factors from volunteers who experienced parabolic flight.2006
- Author(s)
  Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S., Ichimura, Y., Zhai, L., Tong, X., Kita,K.
- Journal Title
  
  J.Int.Soc.Life Info.Sci. 24,2
  
  Pages: 362-363
- Data Source
  KAKENHI-PROJECT-17510040
[Journal Article] Life Science of Gravity-changing Stress; Modulation of UV-mutagenicity in human RSb Cells by Serum Factors from Volunteers Who Experienced Parabolic Flight.2006
- Author(s)
  Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S, Ichimura, Y., Zhai, L., Tong, X., Kita, K.
- Journal Title
  
  J. Intl. Soc. Life Info. Sci. 24・2
  
  Pages: 362-363
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Crystallization and preliminary X-ray analysis of Atg3.2006
- Author(s)
  Yamada Y, Suzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F.
- Journal Title
  
  Acta.Crystallograph.Sect.F.Struct.Biol.Cryst.Commun. 62
  
  Pages: 1016-1017
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510040
[Journal Article] Life science of gravity-changing stress ; modulaiton of UV-mutagenicity in human RSb cells by serum factors from volunteers who experienced parabolic flight.2006
- Author(s)
  Suzuki, N., Chi, X., Takahashi, S., Nomura, J., Sugaya, S., Ichimura, Y., Zhai, L., Tong, X., Kita, K.
- Journal Title
  
  J.Int.Soc.Life Info.Sci. 24
  
  Pages: 362-363
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510040
[Journal Article] Crystallization and preliminary X-ray analysis of Atg3.2006
- Author(s)
  Yamada Y, Zuzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F.
- Journal Title
  
  Acta.Crystallograph.Sect.F.Struct.Biol.Cryst.Commun. 62
  
  Pages: 1016-1017
- Data Source
  KAKENHI-PROJECT-17510040
[Journal Article] Annexin II a novel HSP27-interacted protein, is involved in resistance to UVC-induced cell death in human AP^r-1 cells
- Author(s)
  Tong, X., Kita, K., Karata, K., Zhu, C., Sugaya, S., Ichimura Y, Satoh, M., Tomonaga, T., Nomura, F., Jin, Y, Suzuki, N.
- Journal Title
  
  Photochem. Photobiol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Annexin II,a novel HSP27-interacted protein,is involved in resistance to UVC-induced cell death in human AP-1 cells
- Author(s)
  Tong, X., Kita, K., Karata, K., Zhu, C., Sugaya, S., Ichimura Y., Satoh, M., Tomonaga, T., Nomura, F., Jin, Y., Suzuki, N.
- Journal Title
  
  Photochem.Photobiol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Annexin II, a novel HSP27-interacted protein, is involved in resistance to UVC-induced cell death in human AP^r-1 cells.
- Author(s)
  Tong, X., Kita, K., Karata, K., Zhu, C., Sugaya, S., Ichimura Y., Satoh, M., Tomonaga, T., Nomura, F., Jin, Y., Suzuki, N.
- Journal Title
  
  Photochem. Photobiol (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18510041
[Journal Article] Modulation of mutability in UV-irradiated human RSb cells by serum obtained from parabolic flight volunteers
- Author(s)
  Chi Xiao-Jun, Takahashi S., Nomura J., Sugaya S., Ichimura Y., Zhai L., Tong X., Kita K., Suzuki N.
- Journal Title
  
  Journal of International Society of Life Information Science (In press)
- NAID
  110006242228
- Data Source
  KAKENHI-PROJECT-18510041
[Patent] Reagent for diagnosing tumor, pharmaceutical composition, and screening method2013
- Inventor(s)
  Komatsu M, Ichimura Y
- Industrial Property Rights Holder
  Komatsu M, Ichimura Y
- Industrial Property Rights Type
  特許
- Filing Date
  2013-06-05
- Acquisition Date
  2015-07-28
- Overseas
- Data Source
  KAKENHI-PROJECT-25460400
[Presentation] ULK1/2-mediated p62-phosphorylation at Ser349 is physiologically important for NRF2 activation2022
- Author(s)
  Ryo Ikeda, ○Yoshinobu Ichimura, Daisuke Noshiro, Hideaki Morishita, Shuhei Takada, Tomoko Funakoshi, Satoko Komatsu-Hirota, Shun Kageyama, Ritsuko Arai, Manabu Abe, Kenji Sakimura, Arata Horii, Satoshi Waguri, Nobuo N Noda, and Masaaki Komatsu
- Organizer
  The 10th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06644
[Presentation] ULK1によるp62液―液相分離制御2022
- Author(s)
  一村義信、池田良、森下英晃、能代大輔、野田展生、小松雅明
- Organizer
  日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06644
[Presentation] p62脱リン酸化酵素の同定2020
- Author(s)
  池田良、一村義信、小松聡子、小松雅明
- Organizer
  オートファジー研究会
- Data Source
  KAKENHI-PROJECT-20K06644
[Presentation] リン酸化p62を指標とするオートファジーFlux assay2018
- Author(s)
  一村義信、Omar Faruk、小幡美貴、小松雅明
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H05137
[Presentation] リン酸化p62抗体を利用したオートファジーフラックスアッセイ2018
- Author(s)
  一村義信、Omar Faruk、小幡美貴、小松雅明
- Organizer
  第11回オートファジー研究会
- Data Source
  KAKENHI-PROJECT-16H05137
[Presentation] High-throughput screening for inhibitors of p62-Keap1 protein-protein interaction2017
- Author(s)
  Yoshinobu Ichimura, Tetsuya Saito, Masaaki Komatsu
- Organizer
  The 8th International Symposium on Autophagy (ISA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05137
[Presentation] p62/Sqstm1のKeap1相互作用領域をリン酸化するキナーゼのスクリーニング2016
- Author(s)
  一村義信、小松雅明
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター、東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H05137
[Presentation] 肝臓がんを抑制する新規化合物K67の同定とその作用機序2016
- Author(s)
  一村義信
- Organizer
  第４回創薬等支援技術基盤プラットフォーム公開シンポジウム
- Place of Presentation
  有楽町朝日ホール（東京都千代田区）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05137
[Presentation] リン酸化p62とKEAP1の結合を特異的に阻害する化合物K67の抗がん作用2016
- Author(s)
  一村義信、斉藤哲也、小松雅明
- Organizer
  第10回オートファジー研究会・第4回新学術「オートファジー」班会議
- Place of Presentation
  NASPA ニューオータニ (新潟県南魚沼郡湯沢町)
- Year and Date
  2016-11-13
- Data Source
  KAKENHI-PROJECT-16H05137
[Presentation] Screening of a Responsible Kinase(s) for p62/SQSTM1, an Autophagy-specific Substrate2015
- Author(s)
  Yoshinobu Ichimura
- Organizer
  Symposium on Autophagy (A3)
- Place of Presentation
  Yonsei University, Seoul, Korea
- Year and Date
  2015-10-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460400
[Presentation] オートファジーとKeap1-Nrf2システムの連動2013
- Author(s)
  一村義信
- Organizer
  新学術領域「オートファジーの集学的研究：分子基盤から疾患まで」第１回班会議
- Place of Presentation
  静岡県掛川市　ヤマハリゾート「つま恋」
- Data Source
  KAKENHI-PROJECT-25460400
[Presentation] オートファジーとKeap1-Nrf2システムの接点：その異常と腫瘍増殖2013
- Author(s)
  一村義信
- Organizer
  第1回　がんと代謝研究会
- Place of Presentation
  慶應義塾大学先端生命科学研究所
- Data Source
  KAKENHI-PROJECT-25460400
[Presentation] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy2013
- Author(s)
  一村義信
- Organizer
  第5回　医学研国際シンポジウム
- Place of Presentation
  東京都医学総合研究所
- Invited
- Data Source
  KAKENHI-PROJECT-25460400
[Presentation] Phosphorylation of p62 robustly activates Nrf2 and contributes to tumor development2012
- Author(s)
  一村義信
- Organizer
  The 6th International Symposium on Autophagy
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-22590293
[Presentation] Molecular mechanism of p62 turnover by constitutive autophagy2011
- Author(s)
  一村義信
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22590293
[Presentation] Molecular mechanism of p62 degradation in selective autophagy2010
- Author(s)
  一村義信
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22590293
[Presentation] HSP27 and its interacted protein,is inrvolved in susoeptibility to radiation Iethality in human cells2007
- Author(s)
  Tong Xiao bo, Kita K., Karata K, Zhu C., Sugaya S., Ichimura Y., Sato M., Tomonaga T., Nomura F., Jin Y-H, . Suzuki N.
- Organizer
  Keystone Sylmposia on Melecular and cellular Bielogy, GastOiiitestinal Canoer(T2)
- Place of Presentation
  Beijng,China
- Year and Date
  2007-10-17
- Data Source
  KAKENHI-PROJECT-18510041
[Presentation] HSP27and its interacted protein, is involved in susceptibility to radiation lethality in human cells.2007
- Author(s)
  Tong Xiao bo, Kita K., Karata K., Zhu C., Sugaya S., Ichimura Y., Sato M., Tomonaga T., Nomura F., Jin Y-H., Suzuki N.
- Organizer
  Keystone Symposia on Molecular and cellular Biology, Gastointestinal Cancer (T2)
- Place of Presentation
  Beijing, China
- Year and Date
  2007-10-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18510041
[Presentation] HSP27 and its interacted protein, is involved in susceptibility to radiation lethality in human cells2007
- Author(s)
  Tong Xiao bo, Kita K., Karata K, Zhu C., Sugaya S., Ichimura Y., Sato M., Tomonaga T., Nomura F., Jin Y-H,. Suzuki N.
- Organizer
  Keystone Symposia on Molecular and cellular Biology, Gastointestinal Cancer (T2)
- Place of Presentation
  Beijing, China
- Year and Date
  2007-10-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18510041
[Presentation] p62のリン酸化を介した選択的オートファジーとKeap1-Nrf2システムの連動
- Author(s)
  一村義信、蔭山俊、和栗聡、水島恒裕、本橋ほづみ、山本雅之、小松雅明
- Organizer
  新学術領域「オートファジーの集学的研究：分子基盤から疾患まで」第2回班会議・第8回オートファジー研究会
- Place of Presentation
  「シャトレーゼガトーキングダムサッポロ」北海道札幌市
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-25460400

1. KOMATSU Masaaki (90356254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
2. KITA Kazuko (80302545)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
3. SUZUKI Toshikazu (70270527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
4. SUZUKI Nobuo (90111426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
5. SUGAYA Shigeru (90334177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
6. TAGUCHI Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 石村亮輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 曽友深

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 和栗聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 田中啓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ichimura Yoshinobu 一村 義信

ICHIMURA Yoshinobu 一村 義信

ICHIMURA Yoshinob 一村 義信

Research Projects

Research Products

Co-Researchers

リン酸化によるp62の動態調節機構とその生理機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on molecular mechanism of p62-Keap1-Nrf2 systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Phosphorylation of p62/Sqstm1 activates Nrf2 during selective autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of p62 degradation in selective autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of modulating effects on X-ray induced cell mutability by chaperons and autophagy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of GRP78-involving process to repair UVC-damaged DNA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Considering the mechanism by which droplets of ALS-FTD-associated SQSTM1/p62 mutants cause pathology2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Description of Novel Variants and Review of Phenotypic Spectrum in UBA5-related Early Epileptic Encephalopathy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selective autophagy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.2018

Author(s)

Ichimura Yoshinobu 一村義信

ICHIMURA Yoshinobu 一村義信

ICHIMURA Yoshinob 一村義信