Shiba Tomoo 志波智生

… Alternative Names

SHIBA Tomoo 志波智生

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Researcher Number	80401206
Other IDs
Affiliation (Current)	2025: 京都工芸繊維大学, 応用生物学系, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 京都工芸繊維大学, 応用生物学系, 教授 2018: 京都工芸繊維大学, 応用生物学系, 教授 2017: 京都工芸繊維大学, 工芸科学研究科, 准教授 2016 – 2017: 京都工芸繊維大学, 応用生物学系, 准教授 2015: 京都工芸繊維大学, その他部局等, 准教授 … More 2011 – 2014: 京都工芸繊維大学, 工芸科学研究科, 准教授 2009: The University of Tokyo, 大学院・医学系研究科, 助教 2007 – 2008: 東京大学, 大学院・総合文化研究科, 助教 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Basic Section 49050:Bacteriology-related / Parasitology (including sanitary zoology) / Biophysics Except Principal Investigator Biological Sciences / Medium-sized Section 37:Biomolecular chemistry and related fields / Functional biochemistry
Keywords	Principal Investigator X線結晶構造解析 / アスコフラノン / トリパノソーマ / Ｘ線結晶構造解析 / 膜表在型タンパク質 / diironタンパク質 / リンゴ酸・キノン酸化還元酵素 (MQO) / リンゴ酸脱水素酵素(MDH) / リンゴ酸代謝 / カンピロバクター … More / アフリカ睡眠病 / 薬剤開発 / シアン耐性酸化酵素 / 顧みられい熱帯病 / 膜表剤型タンパク質 / 二核鉄タンパク質 / エネルギー代謝 / 顧みられない熱帯病 / 微小官 / ダイニン / セレノメチオニン / 多波長異常分散法 / X 線結晶構造解析 / モーター蛋白質 … More Except Principal Investigator X線結晶解析 / ポリスルフィド / パースルフィド / システイン / グルタチオン / 超硫黄 / 結晶構造解析 / 薬剤標的分子 / フラボプロテイン / 酵素の触媒機構 / ユビキノン / 基質結合部位 / 阻害剤 / 共結晶 / X線結晶構造解析 / ユビキノン結合部位 / NADH dehydrogenase / シトクロムb_6f複合体 / 分子間相互作用 / 光合成電子伝達 / 膜タンパク質 / 光合成 / 結晶解析 / エネルギー変換 / 分子モーター Less

Drug development targeting Campylobacter's malate metabolic pathwayPrincipal Investigator
- Principal Investigator
  
  志波智生
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Kyoto Institute of Technology
Endogenous formation and biological functions of a novel supersulfide S-thiomethylcysteine and its derivatives
- Principal Investigator
  
  澤智裕
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kumamoto University
Development of alternative oxidase inhibitors for the treatment of African trypanosomiasisPrincipal Investigator
- Principal Investigator
  
  志波智生
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  Kyoto Institute of Technology
Study on the reaction mechanism of type II NADH dehydrogenase by structural and biochemical analyses of the enzyme-inhibitor interaction.
- Principal Investigator
  
  Yamashita Tetsuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagawa University
Drug development of African sleeping sickness targeting energy metabolic pathwayPrincipal Investigator
- Principal Investigator
  
  Shiba Tomoo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto Institute of Technology
The studies of reaction mechanism of cyanide-insensitive alternative oxidase from Trypanosoma brucei (TAO), a promising drug targetPrincipal Investigator
- Principal Investigator
  
  SHIBA Tomoo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto Institute of Technology
Structure analysis of cytoplasmic dynein stalk domainPrincipal Investigator
- Principal Investigator
  
  SHIBA Tomoo
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
膜面新規ヘム鉄の役割解明を目指す高等植物チトクロムb6f複合体のX線構造解析
- Principal Investigator
  
  栗栖源嗣
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
巨大モーター蛋白質ダイニンのX線による原子レベル構造研究
- Principal Investigator
  
  栗栖源嗣
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling, Chapter 19, Structure and Mechanism of Action of the Alternative Quinol Oxidases2016
- Author(s)
  Young L, May B, Shiba T, Harada S, Inaoka DK, Kita K, Moore AL
- Total Pages
  739
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26440027
[Journal Article] Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase2019
- Author(s)
  Shiba Tomoo、Inaoka Daniel Ken、Takahashi Gen、Tsuge Chiaki、Kido Yasutoshi、Young Luke、Ueda Satoshi、Balogun Emmanuel Oluwadare、Nara Takeshi、Honma Teruki、Tanaka Akiko、Inoue Masayuki、Saimoto Hiroyuki、Harada Shigeharu、Moore Anthony L.、Kita Kiyoshi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Bioenergetics
  
  Volume: 1860 Issue: 5 Pages: 375-382
- DOI
  10.1016/j.bbabio.2019.03.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K12621, KAKENHI-PROJECT-17K15679, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-17F17420, KAKENHI-PROJECT-16K15268, KAKENHI-PROJECT-18K07092, KAKENHI-PROJECT-18KK0454
[Journal Article] NovelCharacteristics of Mitochondrial Electron Transport Chain from Eimeria tenella2018
- Author(s)
  Matsubayashi M, Inaoka DK, Komatsuya K, Hatta T, Kawahara F, Sakamoto K,Hikosaka K, Yamagishi J, Sasai K, Shiba T, Harada S, Tsuji N, Kita K.
- Journal Title
  
  Genes (Basel)
  
  Volume: 10 Issue: 1 Pages: 1-1
- DOI
  10.3390/genes10010029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03919, KAKENHI-PROJECT-17F17420, KAKENHI-PROJECT-17H04641, KAKENHI-PROJECT-16K08025
[Journal Article] Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense2018
- Author(s)
  Ebiloma Godwin U., Ayuga Teresa Diaz, Balogun Emmanuel O., Gil Lucia Abad, Donachie Anne, Kaiser Marcel, Herraiz Tomas, Inaoka Daniel K., Shiba Tomoo, Harada Shigeharu, Kita Kiyoshi, de Koning Harry P., Dardonville Christophe
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 150 Pages: 385-402
- DOI
  10.1016/j.ejmech.2018.02.075
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17420
[Journal Article] Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions2018
- Author(s)
  Miyazaki Yukiko、Inaoka Daniel K.、Shiba Tomoo、Saimoto Hiroyuki、Sakura Takaya、Amalia Eri、Kido Yasutoshi、Sakai Chika、Nakamura Mari、Moore Anthony L.、Harada Shigeharu、Kita Kiyoshi
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 9 Pages: 997-997
- DOI
  10.3389/fphar.2018.00997
- NAID
  120006987943
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15679, KAKENHI-PROJECT-17F17420, KAKENHI-PROJECT-16K05915
[Journal Article] SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase2018
- Author(s)
  Meco-Navas A, Ebiloma GU, Martin-Dominguez A, Martinez-Benayas I, Cueto-Diaz EJ, Alhejely AS, Balogun EO, Saito M, Matsui M, Arai N, Shiba T, Harada S, de Koning HP, Dardonville C.
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 9 Issue: 9 Pages: 293-298
- DOI
  10.1021/acsmedchemlett.8b00282
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17420
[Journal Article] Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors2018
- Author(s)
  Yamashita Tetsuo, Inaoka Daniel Ken, Shiba Tomoo, Oohashi Takumi, Iwata So, Yagi Takao, Kosaka Hiroaki, Miyoshi Hideto, Harada Shigeharu, Kita Kiyoshi, Hirano Katsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2427-2427
- DOI
  10.1038/s41598-018-20775-6
- NAID
  120006532084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17420, KAKENHI-PROJECT-15K07005
[Journal Article] Biochemical studies of membrane bound Plasmodium falciparum mitochondrial L -malate:quinone oxidoreductase, a potential drug target2018
- Author(s)
  Hartuti, E. D.; Inaoka, D. K.; Komatsuya, K.; Miyazaki, Y.; Miller, R. J.; Wang, X.; Sadikin, M.; Prabandari, E. E.; Waluyo, D.; Kuroda, M.; Amalia, E.; Matsuo, Y.; Nugroho, N. B.; Saimoto, H.; Pramisandi, A.; Watanabe, Y.; Mori, M.; Shiomi, K.; Balogun, E. O.; Shiba, T.; Harada, S.; Nozaki, T.; Kita, K
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Bioenergetics
  
  Volume: 1859 Issue: 3 Pages: 191-200
- DOI
  10.1016/j.bbabio.2017.12.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08344, KAKENHI-PROJECT-17F17420
[Journal Article] Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.2017
- Author(s)
  Francisco Jose Fueyo Gonzalez, Godwin U. Ebiloma, Carolina Izquierdo Garcia, Victor Bruggeman, Jose Maria Sanchez Villamanan, Anne Donachie, Emmanuel Oluwadare Balogun, Daniel Ken Inaoka, Tomoo Shiba, Shigeharu Harada, Kiyoshi Kita, Harry P. de Koning, Christophe Dardonville
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 60(4) Issue: 4 Pages: 1509-1522
- DOI
  10.1021/acs.jmedchem.6b01740
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253025, KAKENHI-PROJECT-26440027
[Journal Article] The hyperthermophilic cystathionine γ-synthase from the aerobic crenarchaeon Sulfolobus tokodaii: expression, purification, crystallization and structural insights2017
- Author(s)
  Sato D, Shiba T, Mizuno S, Kawamura A, Hanada S, Yamada T, Shinozaki M, Yanagitani M, Tamura T, Inagaki K, Harada S
- Journal Title
  
  Acta Cryst., F
  
  Volume: 73 Issue: 3 Pages: 152-158
- DOI
  10.1107/s2053230x17002011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26440027, KAKENHI-PROJECT-15K14695
[Journal Article] Structural and mechanistic insights into homocysteine degradation by a mutant of methionine γ-lyase based on substrate-assisted catalysis2017
- Author(s)
  Sato D, Shiba T, Yunoto S, Furutani K, Fukumoto M, Kudou D, Tamura T, Inagaki K, Harada S.
- Journal Title
  
  Protein Science
  
  Volume: 26 Issue: 6 Pages: 152-158
- DOI
  10.1002/pro.3158
- NAID
  130007628790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26440027, KAKENHI-PROJECT-15K14695
[Journal Article] 2.Pharmacophore Modeling for Anti-Chagas Drug Design Using the Fragment Molecular Orbital Method2015
- Author(s)
  Yoshino R, Yasuo N, Inaoka DK, Hagiwara Y, Ohno K, Orita M, Inoue M, Shiba T, Harada S, Honma T, Balogun EO, da Rocha JR, Montanari CA, Kita K, Sekijima M
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 5 Pages: 1-15
- DOI
  10.1371/journal.pone.0125829
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440027, KAKENHI-PROJECT-24240044, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26253025, KAKENHI-PROJECT-15H02776, KAKENHI-PROJECT-26870119
[Journal Article] 1.Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria2015
- Author(s)
  Inaoka DK, Shiba T, Sato D, Balogun EO, Sasaki T, Nagahama M, Oda M, Matsuoka S, Ohmori J, Honma T, Inoue M, Kita K, Harada S
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 16 Issue: 7 Pages: 15287-15308
- DOI
  10.3390/ijms160715287
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440027, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26870119
[Journal Article] 希少疾病のアカデミア創薬–グローバルオーファンドラッグ創成をめざして–2014
- Author(s)
  北潔, 志波智生, 原田繁春
- Journal Title
  
  実験医学増刊
  
  Volume: 32(2) Pages: 210-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] Anemia amelioration by lactose infusion during trypanosomosis could be associated with erythrocytes membrane de-galactosylation2014
- Author(s)
  Balogun EO, Balogun JAB, Yusuf S, Inuwa HM, Ndams IS, Sheridan P, Inaoka DK, Shiba T, Harada S, Kita K, Esievo KAN, Nok AJ.
- Journal Title
  
  Veterinary Parasitology
  
  Volume: 199 Pages: 259-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] 希少疾病のアカデミア創薬 – グローバルオーファンドラッグ創成をめざして –2014
- Author(s)
  北潔, 志波智生, 原田繁春
- Journal Title
  
  実験医学増刊
  
  Volume: 32 Pages: 210-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] 微生物からの贈り物アスコフラノン -　アフリカ睡眠病からがん細胞まで　-2014
- Author(s)
  北潔, 志波智生, 斎本博之, 稲岡ダニエル健, 原田繁春
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 24-4 Pages: 44-50
- NAID
  130007674627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440027
[Journal Article] Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase2014
- Author(s)
  Emmanuel Oluwadare Balogun, Daniel Ken Inaoka, Tomoo Shiba, Yasutoshi Kido, Chiaki Tsuge, Takeshi Nara, Takashi Aoki, Teruki Honma, Akiko Tanaka, Masayuki Inoue, Shigeru Matsuoka, Paul A.M. Michels, Kiyoshi Kita, Shigeharu Harada
- Journal Title
  
  Molecular Microbiology
  
  Volume: 94 Issue: 6 Pages: 1315-1329
- DOI
  10.1111/mmi.12831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-25670205, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26440027
[Journal Article] Probing the ubiquinol-binding site of recombinant Sauromatum guttatum alternative oxidase expressed in E. coli membranes through site-directed mutagenesis2014
- Author(s)
  Luke Young, Benjamin May, Alice Pendlebury-Watt, Julia Shearman, Catherine Elliott, Mary S. Albury, Tomoo Shiba, Daniel Ken Inaoka, Shigeharu Harada, Kiyoshi Kita, Anthony L. Moore
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Bioenergetics
  
  Volume: 1837 Issue: 7 Pages: 1219-1225
- DOI
  10.1016/j.bbabio.2014.01.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-26440027
[Journal Article] Unraveling the heater : new insights into the structure of the alternative oxidase2013
- Author(s)
  Moore AL, Shiba T, Young L, Harada S, Kita K, Ito K.
- Journal Title
  
  Annu. Rev Plant Biol.
  
  Volume: 64 Pages: 637-663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] Identification and Characterization of Sialidase-Like Activity in the Developmental Stages of Amblyomma Variegatum2013
- Author(s)
  Audu J. Natala, Emmanuel 0. Balogun, Joshua A. B. Balogun, Hajiya M. Inuwa, Andrew J. Nok, Tomoo Shiba, Shigeharu Harada,Kiyoshi Kita, Rowland l. S. Agbede, King A. N. Esievo
- Journal Title
  
  Journal of Medical Entomology
  
  Volume: 50 (1) Issue: 1 Pages: 85-93
- DOI
  10.1603/me12152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02102, KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-23570131
[Journal Article] The alternative oxidases : simple oxidoreductase proteins with complex functions2013
- Author(s)
  Young L, Shiba T, Harada S, Kita K, Albury MS, Moore AL.
- Journal Title
  
  Biochem Soc Trans.
  
  Volume: 41 Pages: 1305-1311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] Structure of the trypanosome cyanide-insensitive alternative oxidase2013
- Author(s)
  Shiba T, Kido Y, Sakamoto K, Inaoka DK, Tsuge C, Tatsumi R, Takahashi G, Balogun EO, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Saimoto H, Moore AL, Harada S, Kita K.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 110 Pages: 4580-4585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] Identification and characterization of sialidase-like activity in the developmental stages of Amblyomma variegatum2013
- Author(s)
  Natala AJ, Balogun EO, Balogun JA, Inuwa HM, Nok AJ, Shiba T, Harada S, Kita K, Agbede RI, Esievo KA.
- Journal Title
  
  J. of Med. Entomol.
  
  Volume: 50 Pages: 85-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] アフリカ睡眠病治療薬の候補化合物と標的タンパク質との複合体構造2013
- Author(s)
  志波智生, 高橋元, 原田繁春, 斎本博之, 城戸康年, 稲岡ダニエル健, 北潔.
- Journal Title
  
  日本結晶学会誌
  
  Volume: 55 Pages: 254-259
- NAID
  10031194726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] The alternative oxidases: simple oxidoreductase proteins with complex functions2013
- Author(s)
  Luke Young, Tomoo Shiba, Shigeharu Harada, Kiyoshi Kita, Mary S. Albury, Anthony L. Moore
- Journal Title
  
  Biochem. Soc. Trans.
  
  Volume: 41 Issue: 5 Pages: 1305-1311
- DOI
  10.1042/bst20130073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-23570131
[Journal Article] Structures of cyanobacteriochromes from phototaxis regulators AnPixJ and TePixJ reveal general and specific photoconversion mechanism2013
- Author(s)
  Narikawa R, Ishizuka T, Muraki N, Shiba T, Kurisu G, Ikeuchi M.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 110 Pages: 918-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target2013
- Author(s)
  Balogun EO, Inaoka DK, Shiba T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PA, Harada S, Kita K.
- Journal Title
  
  J. Biochemistry
  
  Volume: 154 Pages: 77-84
- NAID
  40019683344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] Unraveling the Heater: New Insights into the Structure of the Alternative Oxidase2013
- Author(s)
  Anthony L. Moore, Tomoo Shiba, Luke Young, Shigeharu Harada, Kiyoshi Kita, Kikukatsu Ito
- Journal Title
  
  Annual Review of Plant Biology
  
  Volume: 64 Issue: 1 Pages: 637-663
- DOI
  10.1146/annurev-arplant-042811-105432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-23570131, KAKENHI-PROJECT-24380182
[Journal Article] The role of amino acid residues in the active site of L-methionineγ-lyase from Pseudomonas putida2012
- Author(s)
  Fukumoto M, Kudou D, Murano S, Shiba T, Sato D, Tamura T, Harada S, Inagaki K.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] The Role of Amino Acid Residues in the Active Site of <small>L</small>-Methionine γ-lyase from <i>Pseudomonas putida</i>2012
- Author(s)
  Fukumoto, M.
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 76 Issue: 7 Pages: 1275-1284
- DOI
  10.1271/bbb.110906
- NAID
  130001862713
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-23570131, KAKENHI-PROJECT-24560962
[Journal Article] Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum2012
- Author(s)
  Shimizu H, Osanai A, Sakamoto K, Inaoka DK, Shiba T, Harada S, Kita K.
- Journal Title
  
  J. Biochemistry
  
  Volume: 151
- NAID
  10031166100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570131
[Journal Article] Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei2010
- Author(s)
  Kido, Y., Shiba, T., Inaoka, D.K., Sakamoto, K., Nara, T., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, S., Moore, A., Harada, S., Kita, K.
- Journal Title
  
  Acta Cryst F66
  
  Pages: 275-278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770118
[Journal Article] Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Trypanosoma brucei gambiense glycerol kinase2010
- Author(s)
  Balogun, E.O., Inaoka, D.K., Kido, Y., Shiba, T., Nara, T., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, Michels, P.S., Harada, S., Kita, K.
- Journal Title
  
  Acta Cryst F66
  
  Pages: 304-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770118
[Journal Article] Crystallization and preliminary X-ray studies of the chromophore-binding domain of cyanobacteriochrome AnPixJ from Anabaena sp. PCC 71202009
- Author(s)
  Narikawa, R., Muraki, N., Shiba, T., Ikeuchi, M., Kurisu, G.
- Journal Title
  
  Acta Cryst F65
  
  Pages: 159-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770118
[Journal Article] Crystallization and preliminary X-ray studies of the chromophore-binding domain of cyanobacteriochrome AnPixJ from Anabaena sp. PCC 71202009
- Author(s)
  Narikawa, R., Muraki, N., Shiba, T., Ikeuchi, M. and Kurisu, G.
- Journal Title
  
  Acta Crystallographica. Sec. F. 65
  
  Pages: 159-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19036003
[Journal Article] Functional importance of Crenarchaeaspecific extra-loop revealed by an X-ray structure of a hetero-tetrameric crenarchaeal splicing endonuclease2009
- Author(s)
  Yoshinari1, S., Shiba, T., Inaoka, D.K., Itoh, T., Kurisu, G., Harada, S., Kita, K., Watanabe, Y.
- Journal Title
  
  Nucleic. Acids Res. 37
  
  Pages: 4787-4798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770118
[Journal Article] Crystallization and preliminary X-ray studies of ferredoxin-NAD (P)^+ reductase from Chlorobium tepidum2008
- Author(s)
  N. Muraki, D. Seo, T. Shiba, T. Sakurai, G. Kurisu
- Journal Title
  
  Acta Crystallographica Section F 64
  
  Pages: 186-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19036003
[Journal Article] Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products : atomic resolutior insights into mechanisms of dihydroorotate oxidation and fumarate reduction2008
- Author(s)
  Inaoka, D.K., Sakamoto, K., Shimizu, H., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Kita, K. and Harada, S.
- Journal Title
  
  Biochemistry 47
  
  Pages: 10881-10891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19036003
[Journal Article] Structures of Trypanosoma cruzi Dihydroorotate Dehydrogenase Complexed with Substrates and Products: Atomic Resolution Insights into Mechanisms of Dihydroorotate Oxidation and Fumarate Reduction2008
- Author(s)
  Inaoka, D.K., Sakamoto, K., Shimizu, H., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Kita, K., Harada, S.
- Journal Title
  
  Biochemistry 47
  
  Pages: 10881-10891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770118
[Journal Article] Crystallization and preliminary X-ray studies of ferredoxin-NAD(P)^+ reductase from Chiorobium tepidum2008
- Author(s)
  N. Muraki, D. Seo, T. Shiba, T. Sakurai, G. Kurisu
- Journal Title
  
  Acta Crystallographica Section F 64
  
  Pages: 186-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18054008
[Journal Article] Crystallization and preliminary X-ray studies of ferredoxin-NAD(P)+ reductase from Chlorobium tepidum2008
- Author(s)
  Muraki, N., Seo, D., Shiba, T., Sakurai, T., Kurisu, G.
- Journal Title
  
  Acta Crystallographica. Sec. F 64
  
  Pages: 186-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19036003
[Presentation] 競合および混合阻害剤との共結晶構造解析により明らかとなった出芽酵母由来Type II NADH脱水素酵素のユビキノン結合部位2018
- Author(s)
  山下哲生，稲岡健ダニエル，志波智生，大橋匠，岩田想，矢木隆雄，三芳秀，原田繁春，北潔，平野勝也
- Organizer
  日本農芸化学会中四国支部第51回講演会
- Data Source
  KAKENHI-PROJECT-15K07005
[Presentation] アフリカトリパノソーマのシアン耐性酸化酵素(TAO)とクマリン骨格をもつ新規阻害剤との複合体結晶構造2016
- Author(s)
  西藤万智, 志波智生, 上田慧, 稲岡ダニエル健, 城戸康年, バログンエマニエル, アントニームーア, 斎本博之, 北潔, 原田繁春
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26440027
[Presentation] Serendipitous discovery of trypanocidal compounds with dual-inhibition for African trypanosomes glycerol kinase and alternative oxidase2016
- Author(s)
  Emmnuel O. Balogun, Daniel K. Inaoka, Tomoo Shiba, Chiaki Tsuge, Benjamin May, Tomohiro Sato, Yasutoshi Kido, Takeshi Nara, Takashi Aoki, Teruki Honma, Akiko Tanaka, Masayuki Inoue, Shigeru Matsuoka, Paul A.M. Michels, Anthony L Moore, Shigeharu Harada, Kiyoshi Kita
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26440027
[Presentation] アフリカトリパノソーマのシアン耐性酸化酵素(TAO)と異なる骨格を持つ阻害剤、アスコフラノン及びフェルレノールとの複合体構造2015
- Author(s)
  上田慧、中井万智、志波智生、高橋元、稲岡ダニエル健、城戸康年、坂元君年、柘植千明、Emmanuel Oluwadare Balogun、奈良武司、青木孝、本間光貴、田仲昭子、井上将行、松岡茂、Moore L. Anthony、斎本博之、北潔、原田繁春
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440027
[Presentation] トリパノソーマシアン耐性酸化酵素(TAO)とグリセロールキナーゼ(GK)の結晶構造2015
- Author(s)
  志波智生、エマニュエルバログン、稲岡ダニエル健、原田繁春、北潔
- Organizer
  第41回生体エネルギー研究会討論会
- Place of Presentation
  東京
- Year and Date
  2015-12-21
- Data Source
  KAKENHI-PROJECT-26440027
[Presentation] 出芽酵母由来Type II NADH dehydrogenase (NDH-2)のユビキノン競合阻害剤との高分解能複合体構造解析2015
- Author(s)
  大橋拓未、稲岡ダニエル健、山下哲生、志波智生、岩田想、原田繁春、北潔
- Organizer
  日本生体エネルギー研究会　第41回討論会
- Place of Presentation
  東京大学医学部1号館講堂
- Year and Date
  2015-12-23
- Data Source
  KAKENHI-PROJECT-15K07005
[Presentation] The crystal structures of trypanosomal cyanide-insensitive alternative oxidase (TAO) and glycerol kinase (GK)2015
- Author(s)
  Tomoo Shiba, Emmanuel Oluwadare Balogun, Daniel Ken Inaoka, Shigeharu Harada, Kiyoshi Kita
- Organizer
  3rd International Picobiology Institute Symposium
- Place of Presentation
  兵庫県立大学
- Year and Date
  2015-12-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440027
[Presentation] The search for inhibitors of African trypanosomes glycerol kinase2013
- Author(s)
  Balogun EO, Inaoka DK, Shiba T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PA, Kita K, Harada S.
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] アフリカトリパノソーマのシアン耐性酸化酵素 (TAO)と新規阻害剤: フェルレノールとの複合体の結晶構造2013
- Author(s)
  高橋元, 志波智生, 上田慧, 稲岡ダニエル健, 城戸康年, 坂元君年, 柘植千明, Oluwadare Balogun Emmanuel, 奈良武司, 青木孝, 本間光貴, 田仲昭子, 井上将行, 松岡茂, L. Moore Anthony, 斎本博之, 原田繁春, 北潔
- Organizer
  第86会日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] アフリカトリパノソーマの薬剤標的「シアン耐性酸化酵素Trypanosome Alternative Oxidase (TAO)」の結晶構造解析2013
- Author(s)
  志波智生、高橋元、城戸康年、稲岡ダニエル健、坂元君年、柘植千明、辰巳涼子、Emmanuel Oluwadare Balogun、奈良武司、青木孝、本間光貴、田仲昭子、井上将行、松岡茂、Anthony L. Moore、斎本博之、原田繁春、北潔
- Organizer
  第86会日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] シアン耐性酸化酵素Trypanosome Alternative Oxidase(TAO)の結晶構造2013
- Author(s)
  志波智生, 城戸康年, 高橋元, 稲岡ダニエル健, 坂元君年, 奈良武司, 青木孝, 本間光貴, 田仲昭子, 井上将行, 松岡茂, 斎本博之, 原田繁春, 北潔
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] アフリカトリパノソーマのシアン耐性酸化酵素(TAO)と新規阻害剤:フェルレノールとの複合体の結晶構造2013
- Author(s)
  高橋元, 志波智生, 上田慧, 稲岡ダニエル健, 城戸康年, 坂元君年, 柘植千明, Balogun EO, 奈良武司, 青木孝, 本間光貴, 田仲昭子, 井上将行, 松岡茂, Moore AL, 斎本博之, 原田繁春, 北潔
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] アフリカトリパノソーマの薬剤標的「シアン耐性酸化酵素Trypanosome Alternative Oxidase (TAO)」の結晶構造解析2013
- Author(s)
  志波智生, 高橋元, 城戸康年, 稲岡ダニエル健, 坂元君年, 柘植千明, 辰巳涼子, Balogun EO, 奈良武司, 青木孝, 本間光貴, 田仲昭子, 井上将行, 松岡茂, Moore AL, 斎本博之, 原田繁春, 北潔
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] アフリカトリパノソーマ症の薬剤標的「シアン耐性酸化酵素Trypanosome Alternative Oxidase (TAO)」の精製と結晶構造解析2012
- Author(s)
  高橋元、志波智生、城戸康年、ダニエル健稲岡、坂元君年、奈良武司、青木孝、本間光貴、田仲昭子、井上将行、松岡茂、Moore Anthony、斎本博之、原田繁春、北潔
- Organizer
  日本生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] アフリカトリパノソーマの薬剤標的「シアン耐性酸化酵素Trypanosome Alternative Oxidase（TAO）」の結晶構造2012
- Author(s)
  志波智生、城戸康年、稲岡ダニエル健、坂元君年、奈良武司、青木孝、本間光貴、田仲昭子、井上将行、松岡茂、ムーアアンソニィー、斎本博之、原田繁春、北潔
- Organizer
  日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] Structure-based approach for developing trypanosome-specific glycerol kinase inhibitor(s)2012
- Author(s)
  Balogun EO, Inaoka DK, Shiba T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PA, Harada S, Kita K.
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] アフリカトリパノソーマの薬剤標的「シアン耐性酸化酵素Trypanosome Alternative Oxidase(TAO)」の結晶構造2012
- Author(s)
  志波智生, 城戸康年, 稲岡ダニエル健, 坂元君年, 奈良武司, 青木孝, 本間光貴, 田仲昭子, 井上将行, 松岡茂, Moore AL, 斎本博之, 原田繁春, 北潔
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] アフリカトリパノソーマ症の薬剤標的「シアン耐性酸化酵素Trypanosome Alternative Oxidase (TAO)」の精製と結晶構造解析2012
- Author(s)
  高橋元, 志波智生, 城戸康年, 稲岡ダニエル健, 坂元君年, 奈良武司, 青木孝, 本間光貴, 田仲昭子, 井上将行, 松岡茂, Moore AL, 斎本博之, 原田繁春, 北潔
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] Structural analysis of glycerol kinase from human African trypanosomes for anti-trypanosomal drug design2011
- Author(s)
  Balogun EO, 稲岡ダニエル健, 志波智生, 城戸康年, 奈良武司, 青木孝, 本間光貴, 田仲昭子, 井上将行, 松岡茂, Michels PA, 原田繁春, 北潔
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] アフリカトリパノソーマの薬剤標的「シアン耐性酸化酵素Trypanosome Alternative Oxidase (TAO)」の結晶構造2011
- Author(s)
  志波智生
- Organizer
  日本結晶学会年会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] トリパノソーマ原虫のミトコンドリアの内膜に局在する「シアン耐性酸化酵素Trypanosome Alternative Oxidase (TAO)」の結晶構造2011
- Author(s)
  志波智生
- Organizer
  日本生化学会大会
- Place of Presentation
  国立京都国際会議場
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] トリパノソーマ原虫のミトコンドリアの内膜に局在する「シアン耐性酸化酵素Trypanosome Alternative Oxidase (TAO)」の結晶構造」2011
- Author(s)
  志波智生, 城戸康年, 稲岡ダニエル健, 坂元君年, 奈良武司, 青木孝, 本間光貴, 田仲昭子, 井上将行, 松岡茂, 斎本博之, Moore AL, 原田繁春, 北潔
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23570131
[Presentation] Crystallographic studies of ferredoxin-NAD(P)+ reductase from Chlorobium tepidum2008
- Author(s)
  Norifumi Muraki, Tomoo Shiba, Daisuke Seo, Takeshi Sakurai and Genji Kurisu
- Organizer
  International Union of Crystallography, 2008
- Place of Presentation
  大阪国際会議場
- Year and Date
  2008-08-25
- Data Source
  KAKENHI-PROJECT-19036003
[Presentation] Crystallographic studies of ferredoxin-NAD(P)+ reductase from Chlorobium tepidum2008
- Author(s)
  Shiba, T., Muraki, N., Seo, D., Sakurai, T., Kurisu, G.
- Organizer
  第21回国際結晶学会議
- Place of Presentation
  大阪国際会議場
- Year and Date
  2008-08-29
- Data Source
  KAKENHI-PROJECT-20770118
[Presentation] Crystallographic studies of ferredoxinNAD(P)+ reductase from Chlorobium tepidum2008
- Author(s)
  Tomoo Shiba , Norifumi Muraki, D
- Organizer
  The International Union of Crystallography (IUCr) 2008
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20770118
[Presentation] Glycerol kinase from human African trypanosomes possess an intrinsic acid phosphatase activity
- Author(s)
  Balogun Emmanuel O., Inaoka Daniel K., Shiba Tomoo, Sakamoto Kimitoshi, Kido Yasutoshi, Nara Takeshi, Aoki Takashi, Honma Teruki, Tanaka Akiko, Inoue Masayuki, Matsuoka Shigeru, Michels Paul AM., Harada Shigeharu, Kita Kiyoshi
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26440027
[Presentation] アフリカトリパノソーマのシアン耐性酸化酵素 (TAO)と新規阻害剤: フェルレノールとの複合体の結晶構造
- Author(s)
  上田慧、志波智生、高橋元、稲岡ダニエル健、城戸康年、坂元君年、柘植千明、Emmanuel Oluwadare Balogun、奈良武司、青木孝、本間光貴、田仲昭子、井上将行、松岡茂、Anthony L. Moore、斎本博之、原田繁春、北潔
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26440027
[Presentation] アフリカトリパノソーマのシアン耐性酸化酵素（TAO）と新規阻害剤:フェルレノールとの複合体晶構造
- Author(s)
  上田慧、志波智生、高橋元、稲岡ダニエル健、城戸康年、坂元君年、柘植千明、本間光貴、田仲昭子、斎本博之、北潔、原田繁春
- Organizer
  第１４回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26440027

1. Inaoka Daniel K (10623803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 栗栖源嗣 (90294131)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. Yamashita Tetsuo (80444727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. KITA Kiyoshi (90134444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. HARADA Shigeharu (80156504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 須藤和夫 (20111453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 澤智裕 (30284756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. EBILOMA GODWIN

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. HATTA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. MORI Mihoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 城戸康年

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. BALOGUN E.O.

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 奈良武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 佐藤健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 坪内暁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shiba Tomoo 志波 智生

SHIBA Tomoo 志波 智生

Research Projects

Research Products

Co-Researchers

Drug development targeting Campylobacter's malate metabolic pathwayPrincipal Investigator

Principal Investigator

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Endogenous formation and biological functions of a novel supersulfide S-thiomethylcysteine and its derivatives

Principal Investigator

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Review Section

Research Institution

Development of alternative oxidase inhibitors for the treatment of African trypanosomiasisPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Study on the reaction mechanism of type II NADH dehydrogenase by structural and biochemical analyses of the enzyme-inhibitor interaction.

Principal Investigator

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Drug development of African sleeping sickness targeting energy metabolic pathwayPrincipal Investigator

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The studies of reaction mechanism of cyanide-insensitive alternative oxidase from Trypanosoma brucei (TAO), a promising drug targetPrincipal Investigator

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Structure analysis of cytoplasmic dynein stalk domainPrincipal Investigator

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膜面新規ヘム鉄の役割解明を目指す高等植物チトクロムb6f複合体のX線構造解析

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巨大モーター蛋白質ダイニンのX線による原子レベル構造研究

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[Book] Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling, Chapter 19, Structure and Mechanism of Action of the Alternative Quinol Oxidases2016

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[Journal Article] Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase2019

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[Journal Article] NovelCharacteristics of Mitochondrial Electron Transport Chain from Eimeria tenella2018

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[Journal Article] Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense2018

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[Journal Article] Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions2018

Shiba Tomoo 志波智生

SHIBA Tomoo 志波智生

[Journal Article] 微生物からの贈り物アスコフラノン -　アフリカ睡眠病からがん細胞まで　-2014