Kino Yoshihiro 紀嘉浩

… Alternative Names

KINO Yoshihiro 紀嘉浩

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Researcher Number	80415140
Other IDs
Affiliation (Current)	2025: 明治薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2025: 明治薬科大学, 薬学部, 教授 2022 – 2023: 明治薬科大学, 薬学部, 教授 2017 – 2021: 明治薬科大学, 薬学部, 准教授 2014 – 2017: 明治薬科大学, 薬学部, 講師 2013: 独立行政法人理化学研究所, 脳科学総合研究センター, 客員研究員 2008 – 2012: The Institute of Physical and Chemical Research, 構造神経病理研究チーム, 研究員 2007: The Institute of Physical and Chemical Research, 構造神経病理研究チーム, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 52020:Neurology-related / Nerve anatomy/Neuropathology
Keywords	Principal Investigator RNA結合タンパク質 / 神経変性疾患 / リピート伸長疾患 / ポリグルタミン / MBNL1 / 筋強直性ジストロフィー / 選択的スプライシング / ＦＴＤ / ＡＬＳ / ポリグルタミン病 … More / FTD / ALS / リピート伸長 / ハンチントン病 / 神経核内封入体病 / 眼咽頭遠位型ミオパチー / ポリグリシン / GGCリピート / ヌクレアーゼ / siRNA / アンチセンス核酸 / RNA foci / 翻訳 / hnRNPA1 / ミクログリア / TREM2 / CD33 / hnRNPAファミリー / スプライシング / アルツハイマー病 / タンパク質凝集 / ALS/FTD / 核内凝集体 / MLF2 / 凝集 / C9orf72 / 分子生物学 / ＲＮＡ結合タンパク質 / ＦＵＳ／ＴＬＳ / ノックアウトマウス / FUS/TLS / 凝集体 / CAGリピート / ポリアラニン / ポリアミノ酸 / junctophilin-3 / 神経変性 / CTGリピート / RNA代謝 … More Except Principal Investigator 那須・ハコラ病 / ゲノム編集 / ヒトミクログリアモデル / 免疫組織化学的解析 / 遺伝子発現解析 / 脳分子病態 / 那須ハコラ病 / reactive oxygen species / シグナル伝達 / 免疫組織化学 / 遺伝子診断 / アルツハイマー病 / ROS / oligodendrocytes / microglia / leukoencephalopathy / Nasu-Hakola disease / snRNAs / gp91phox / 白質脳症 / オリゴデンドロサイト / ミクログリア / TREM2 / DAP12 Less

GGCリピート伸長疾患における核内封入体の形成機構とMBNL1の役割Principal Investigator
- Principal Investigator
  
  紀嘉浩
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Meiji Pharmaceutical University
リピートRNA封入体の形成・分解に関わる新規遺伝子の同定Principal Investigator
- Principal Investigator
  
  紀嘉浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Meiji Pharmaceutical University
Molecular Pathology and Therapeutic Approach in Nasu-Hakola Disease
- Principal Investigator
  
  佐藤準一
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Meiji Pharmaceutical University
RNA-binding proteins that regulate microglial genes associated with neurological diseasesPrincipal Investigator
- Principal Investigator
  
  Kino Yoshihiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Meiji Pharmaceutical University
Elucidation of Molecular Pathogenesis of Nasu-Hakola Disease
- Principal Investigator
  
  Satoh Jun-ichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Meiji Pharmaceutical University
A common interactor of protein aggregates associated with ALS/FTD and polyglutamine diseasesPrincipal Investigator
- Principal Investigator
  
  Kino Yoshihiro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Meiji Pharmaceutical University
Loss of function of FUS/TLS in normal and pathological conditionsPrincipal Investigator
- Principal Investigator
  
  Kino Yoshihiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Meiji Pharmaceutical University
  Institute of Physical and Chemical Research
RNA metabolism and RNA-binding proteins in polyglutamine diseasesPrincipal Investigator
- Principal Investigator
  
  KINO Yoshihiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  The Institute of Physical and Chemical Research
Roles of an RNA-binding protein MBNL1 in polyglutamine diseasesPrincipal Investigator
- Principal Investigator
  
  KINO Yoshihiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  The Institute of Physical and Chemical Research
The expression and effects of aberrant RNAs in repeat expansion disordersPrincipal Investigator
- Principal Investigator
  
  KINO Yoshihiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Molecular Mechanisms of Myotonic Dystrophy: RNA-Mediated Pathogenesis and RNA-Binding Proteins. In Myotonic Dystrophy. Disease Mechanism, Current Management and Therapeutic Development.2018
- Author(s)
  Kino Y, Satoh J, Ishiura S.
- Total Pages
  25
- Publisher
  Springer Nature Shigapore Pte Ltd
- ISBN
- Data Source
  KAKENHI-PROJECT-16K07043
[Book] Myotonic Dystrophy (edited by ed by Takahashi MP, Matsumura T)2018
- Author(s)
  Kino Y, Satoh J, Ishiura S
- Publisher
  Springer, Singapore
- ISBN
  9789811305078
- Data Source
  KAKENHI-PROJECT-16K09683
[Book] モデル動物実験マニュアル　疾患モデルの作成と利用　脳・神経疾患　(第2節ハンチントン病モデルマウス)2011
- Author(s)
  紀嘉浩、黒澤大、貫名信行　(分担執筆・三品昌美編)
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-23791007
[Book] モデル動物実験マニュアル疾患モデルの作成と利用脳・神経疾患第2節ハンチントン病モデルマウス2011
- Author(s)
  紀嘉浩、黒澤大、貫名信行(分担執筆:三品昌美編)
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-23791007
[Book] 実験医学 (増刊) 脳神経疾患の分子病態と治療への展開「神経筋疾患とRNA代謝異常」2007
- Author(s)
  紀嘉浩、貫名信行
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19790620
[Journal Article] Translational regulation and protein-coding capacity of the 5′ untranslated region of human TREM22023
- Author(s)
  Yanaizu Motoaki、Adachi Haruka、Araki Makoto、Kontani Kenji、Kino Yoshihiro
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 616-616
- DOI
  10.1038/s42003-023-04998-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14763, KAKENHI-PROJECT-22K07525, KAKENHI-PROJECT-21K20700
[Journal Article] Alzheimer’s Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins2023
- Author(s)
  Komuro Riho、Honda Yuka、Yanaizu Motoaki、Nagahama Masami、Kino Yoshihiro
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 4 Pages: 602-602
- DOI
  10.3390/cells12040602
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07525, KAKENHI-PROJECT-21K20700, KAKENHI-PROJECT-19K07982
[Journal Article] Inhibition of BACE1 and Amyloid-β Aggregation by Meroterpenoids from the Mushroom Albatrellus yasudae2021
- Author(s)
 Masuda Youki、Fujihara Koji、Hayashi Satoshi、Sasaki Hiroaki、Kino Yoshihiro、Kamauchi Hitoshi、Noji Masahiro、Satoh Jun-ichi、Takanami Toshikatsu、Kinoshita Kaoru、Koyama Kiyotaka
- Journal Title
 
 Journal of Natural Products
 
 Volume: 84 Issue: 6 Pages: 1748-1754
- DOI
 10.1021/acs.jnatprod.0c01329
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K07982
[Journal Article] Inhibition of BACE1 and amyloid β aggregation by polyketide from Streptomyces sp.2021
- Author(s)
 Yokoya Masashi、Nakai Keiyo、Kawashima Miki、Kurakado Sanae、Sirimangkalakitti Natchanun、Kino Yoshihiro、Sugita Takashi、Kimura Shinya、Yamanaka Masamichi、Saito Naoki
- Journal Title
 
 Chemical Biology & Drug Design
 
 Volume: 99 Issue: 2 Pages: 264-276
- DOI
 10.1111/cbdd.13980
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K07982, KAKENHI-PROJECT-21K06485
[Journal Article] FACS-array?based cell purification yields a specific transcriptome of striatal medium spiny neurons in a murine Huntington disease model2020
- Author(s)
  Miyazaki Haruko、Yamanaka Tomoyuki、Oyama Fumitaka、Kino Yoshihiro、Kurosawa Masaru、Yamada-Kurosawa Mizuki、Yamano Risa、Shimogori Tomomi、Hattori Nobutaka、Nukina Nobuyuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 29 Pages: 9768-9785
- DOI
  10.1074/jbc.ra120.012983
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0131, KAKENHI-PROJECT-19K07982, KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-18H02723, KAKENHI-PROJECT-20H01113
[Journal Article] CELF2 regulates the species-specific alternative splicing of TREM22020
- Author(s)
  Yanaizu Motoaki、Washizu Chika、Nukina Nobuyuki、Satoh Jun-ichi、Kino Yoshihiro
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1
- DOI
  10.1038/s41598-020-75057-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07982, KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-19J15024
[Journal Article] Reactive astrocytes express Aggregatin (FAM222A) in the brains of Alzheimer's disease and Nasu-Hakola disease2020
- Author(s)
 Satoh Jun-ichi、Kino Yoshihiro、Yanaizu Motoaki、Ishida Tsuyoshi、Saito Yuko
- Journal Title
 
 Intractable & Rare Diseases Research
 
 Volume: 9 Issue: 4 Pages: 217-221
- DOI
 10.5582/irdr.2020.03080
- NAID
 130007936014
- ISSN
 2186-361X, 2186-3644
- Year and Date
 2020-10-31
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K07982, KAKENHI-PROJECT-16H06277
[Journal Article] Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease2019
- Author(s)
  Sone Jun、Mitsuhashi Satomi et al.
- Journal Title
  
  Nature Genetics
  
  Volume: 51 Issue: 8 Pages: 1215-1221
- DOI
  10.1038/s41588-019-0459-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07464, KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-19K07977, KAKENHI-PROJECT-19K07982, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-18H02742, KAKENHI-PROJECT-19H03577, KAKENHI-PROJECT-16K09683
[Journal Article] Microglia express TMEM119 in the brains of Nasu-Hakola disease2019
- Author(s)
  Satoh Jun-ichi、Kino Yoshihiro、Yanaizu Motoaki、Ishida Tsuyoshi、Saito Yuko
- Journal Title
  
  Intractable & Rare Diseases Research
  
  Volume: 8 Issue: 4 Pages: 260-265
- DOI
  10.5582/irdr.2019.01123
- NAID
  130007784569
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07982, KAKENHI-PROJECT-16K09683, KAKENHI-PROJECT-16H06277
[Journal Article] Tandem-genotypes: robust detection of tandem repeat expansions from long DNA reads2019
- Author(s)
  Satomi Mitsuhashi, Martin C. Frith, Takeshi Mizuguchi, Satoko Miyatake, Tomoko Toyota, Hiroaki Adachi, Yoko Oma, Yoshihiro Kino, Hiroaki Mitsuhashi, Naomichi Matsumoto
- Journal Title
  
  Genome Biology
  
  Volume: 20 Issue: 1 Pages: 58-58
- DOI
  10.1186/s13059-019-1667-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09683, KAKENHI-PROJECT-17K10080, KAKENHI-PUBLICLY-17H05708, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-17K15630, KAKENHI-PROJECT-19K07970
[Journal Article] Meroterpenoids with BACE1 Inhibitory Activity from the Fruiting Body of Boletinus asiaticus2019
- Author(s)
  Yatsu Genki、Kino Yoshihiro、Sasaki Hiroaki、Satoh Jun-ichi、Kinoshita Kaoru、Koyama Kiyotaka
- Journal Title
  
  Journal of Natural Products
  
  Volume: 82 Issue: 7 Pages: 1797-1801
- DOI
  10.1021/acs.jnatprod.8b01092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07982, KAKENHI-PROJECT-16K09683
[Journal Article] Microglia express GPNMB in the brains of Alzheimer's disease and Nasu-Hakola disease2019
- Author(s)
  Satoh Jun-ichi、Kino Yoshihiro、Yanaizu Motoaki、Ishida Tsuyoshi、Saito Yuko
- Journal Title
  
  Intractable & Rare Diseases Research
  
  Volume: 8 Issue: 2 Pages: 120-128
- DOI
  10.5582/irdr.2019.01049
- NAID
  130007663178
- ISSN
  2186-361X, 2186-3644
- Year and Date
  2019-05-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07982, KAKENHI-PROJECT-16K09683, KAKENHI-PROJECT-16H06277
[Journal Article] Microglia express gamma-interferon-inducible lysosomal thiol reductase in the brains of Alzheimer's disease and Nasu-Hakola disease2018
- Author(s)
  Satoh Jun-ichi、Kino Yoshihiro、Yanaizu Motoaki、Ishida Tsuyoshi、Saito Yuko
- Journal Title
  
  Intractable & Rare Diseases Research
  
  Volume: 7 Issue: 4 Pages: 251-257
- DOI
  10.5582/irdr.2018.01119
- NAID
  130007533903
- ISSN
  2186-361X, 2186-3644
- Year and Date
  2018-11-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09683, KAKENHI-PROJECT-16K07043
[Journal Article] Small nuclear RNA-mediated modulation of splicing reveals a therapeutic strategy for a TREM2 mutation and its post-transcriptional regulation2018
- Author(s)
  Yanaizu Motoaki、Sakai Kenji、Tosaki Youhei、Kino Yoshihiro、Satoh Jun-ichi
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 6937-6937
- DOI
  10.1038/s41598-018-25204-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09683, KAKENHI-PROJECT-16K07043
[Journal Article] Alzheimer's disease pathology in Nasu-Hakola disease brains2018
- Author(s)
  Satoh JI, Kino Y, Yanaizu M, Saito Y.
- Journal Title
  
  Intractable & Rare Diseases Research
  
  Volume: 7 Issue: 1 Pages: 32-36
- DOI
  10.5582/irdr.2017.01088
- NAID
  130006507559
- ISSN
  2186-361X, 2186-3644
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09683, KAKENHI-PROJECT-16K07043
[Journal Article] Gastric and intestinal proteases resistance of chicken acidic chitinase nominates chitin-containing organisms for alternative whole edible diets for poultry.2017
- Author(s)
  Tabata, E., Kashimura, A., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Kino, Y., Matoska, V., Bauer, P.O. and Oyama, F.
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 6662-6662
- DOI
  10.1038/s41598-017-07146-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07699, KAKENHI-PROJECT-16K09683
[Journal Article] Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease2017
- Author(s)
  Satoh J, Kino Y, Yanaizu M, Tosaki Y, Sakai K, Ishida T, Saito Y
- Journal Title
  
  Intractable & Rare Diseases Research
  
  Volume: 6 Issue: 4 Pages: 262-268
- DOI
  10.5582/irdr.2017.01073
- NAID
  130006252922
- ISSN
  2186-361X, 2186-3644
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07043, KAKENHI-PROJECT-16K09683
[Journal Article] RNA sequencing data analysis identifies a difference in gene expression profile between microglia and astrocytes following LPS-induced neuroinflammation.2017
- Author(s)
  Satoh J, Yanaizu M, Tosaki Y, Sakai K, Kino Y
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 8 Issue: 1 Pages: 60-62
- DOI
  10.1111/cen3.12351
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K07043
[Journal Article] Expression of GPR17, a regulator of oligodendrocyte differentiation and maturation, in Nasu-Hakola disease brains2017
- Author(s)
  Satoh J, Kino Y, Yanaizu M, Tosaki Y, Sakai K, Ishida T, Saito Y.
- Journal Title
  
  Intractable & Rare Diseases Research
  
  Volume: 6 Issue: 1 Pages: 50-54
- DOI
  10.5582/irdr.2016.01097
- NAID
  130005466200
- ISSN
  2186-361X, 2186-3644
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07043
[Journal Article] FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice.2016
- Author(s)
  Kino Y, Washizu C, Kurosawa M, Yamada M, Doi H, Takumi T, Adachi H, Katsuno M, Sobue G, Hicks GG, Hattori N, Shimogori T, Nukina N.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 35236-35236
- DOI
  10.1038/srep35236
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01567, KAKENHI-PLANNED-16H06463, KAKENHI-PROJECT-16H06316, KAKENHI-PROJECT-26293206, KAKENHI-PROJECT-26293207, KAKENHI-PROJECT-25461299, KAKENHI-PROJECT-16K09683
[Journal Article] Targeted sequencing approach to identify genetic mutations in Nasu-Hakola disease2016
- Author(s)
  Satoh J, Yanaizu M, Tosaki Y, Sakai K, Kino Y
- Journal Title
  
  Intractable & Rare Diseases Research
  
  Volume: 5 Issue: 4 Pages: 269-274
- DOI
  10.5582/irdr.2016.01064
- NAID
  130005172451
- ISSN
  2186-361X, 2186-3644
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430054, KAKENHI-PROJECT-16K07043
[Journal Article] Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and Nasu-Hakola disease: lesion staging and dynamic changes of axons and microglial subsets.2016
- Author(s)
  Oyanagi K, Kinoshita M, Suzuki-Kouyama E, Inoue T, Nakahara A, Tokiwai M, Arai N, Satoh JI, Aoki N, Jinnai K, Yazawa I, Arai K, Ishihara K, Kawamura M, Ishizawa K, Hasegawa K, Yagisita S, Amano N, Yoshida K, Terada S, Yoshida M, Akiyama H, Mitsuyama Y, Ikeda SI.
- Journal Title
  
  Brain Pathol.
  
  Volume: 印刷中 Issue: 6 Pages: 748-769
- DOI
  10.1111/bpa.12443
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25119006, KAKENHI-PROJECT-15K06754, KAKENHI-PROJECT-16K07043, KAKENHI-PROJECT-17K09770
[Journal Article] RNA-Seq data mining approach identifies opalin as a reliable marker for myelinating oligodendrocytes.2016
- Author(s)
  Satoh J, Takitani M, Miyoshi J, Kino Y
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 7 Issue: 1 Pages: 66-68
- DOI
  10.1111/cen3.12240
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430054, KAKENHI-PROJECT-16K07043
[Journal Article] P2Y12 expression on microglia in the human brain.2016
- Author(s)
  Satoh J, Tosaki Y, Sakai K, Yanaizu M, Kino Y
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 7 Issue: 4 Pages: 366-368
- DOI
  10.1111/cen3.12320
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430054, KAKENHI-PROJECT-16K07043
[Journal Article] Expression of gp91phox and p22phox, catalytic subunits of NADPH oxidase, on microglia in Nasu-Hakola disease brains2016
- Author(s)
  Satoh J, Kino Y, Yanaizu M, Tosaki Y, Sakai K, Ishida T, Saito Y
- Journal Title
  
  Intractable & Rare Diseases Research
  
  Volume: 5 Issue: 4 Pages: 275-279
- DOI
  10.5582/irdr.2016.01086
- NAID
  130005172458
- ISSN
  2186-361X, 2186-3644
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430054, KAKENHI-PROJECT-16K07043
[Journal Article] TMEM119 marks a subset of microglia in the human brain.2016
- Author(s)
  Satoh J, Kino Y, Asahina N, Takitani M, Miyoshi J, Ishida T, Saito Y
- Journal Title
  
  Neuropathology
  
  Volume: 36 Issue: 1 Pages: 39-49
- DOI
  10.1111/neup.12235
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430054, KAKENHI-PROJECT-16K07043
[Journal Article] RNA-Seq data analysis identifies the comprehensive profile of in vivo interferon-beta-stimulating genes (ISGs) in multiple sclerosis.2016
- Author(s)
  Satoh J, Takitani M, Miyoshi J, Kino Y
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 7 Issue: 1 Pages: 39-51
- DOI
  10.1111/cen3.12268
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430054, KAKENHI-PROJECT-16K07043
[Journal Article] FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis.2015
- Author(s)
  Kino Y, Washizu C, Kurosawa M, Yamada M, Miyazaki H, Akagi T, Hashikawa T, Doi H, Takumi T, Hicks GG, Hattori N, Shimogori T, Nukina N.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 3 Issue: 1 Pages: 24-24
- DOI
  10.1186/s40478-015-0202-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09344, KAKENHI-PROJECT-25461299, KAKENHI-PLANNED-23111005, KAKENHI-PROJECT-25242077, KAKENHI-PROJECT-25253066
[Journal Article] Nuclear localization of MBNL1: splicing-mediated autoregulation and repression of repeat-derived aberrant proteins.2015
- Author(s)
  Kino Y, Washizu C, Kurosawa M, Oma Y, Hattori N, Ishiura S, Nukina N.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 24 Issue: 3 Pages: 740-56
- DOI
  10.1093/hmg/ddu492
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PROJECT-25461299, KAKENHI-PROJECT-25860844
[Journal Article] FUS/TLS2014
- Author(s)
  紀　嘉浩、貫名　信行
- Journal Title
  
  医学のあゆみ　医学・医療のいまがわかるキーワード　2014
  
  Volume: 249 Pages: 438-438
- Data Source
  KAKENHI-PROJECT-25461299
[Journal Article] Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease2014
- Author(s)
  Maheshwari M, Bhutani S, Das A, Mukherjee R, Sharma A, Kino Y, Nukina N, Jana NR
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 23(10) Pages: 2737-2751
- Data Source
  KAKENHI-PROJECT-23791007
[Journal Article] Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-22014
- Author(s)
  Asada, A., Yamazaki, R., Kino, Y., Saito, T., Kimura, T., Miyake, M., Hasegawa, M., Nukina, N. & Hisanaga, S.
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 563 Pages: 112-117
- DOI
  10.1016/j.neulet.2014.01.046
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PROJECT-23791007, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25290024, KAKENHI-PROJECT-25461299, KAKENHI-PLANNED-26117005
[Journal Article] FUS/TLS2014
- Author(s)
  紀　嘉浩、貫名　信行
- Journal Title
  
  医学のあゆみ　医学・医療のいまがわかるキーワード　2014
  
  Volume: 249 Pages: 438-438
- Data Source
  KAKENHI-PROJECT-23791007
[Journal Article] FUS/TLS医学のあゆみ医学2014
- Author(s)
  紀嘉浩、貫名信行
- Journal Title
  
  医療のいまがわかるキーワード2014
  
  Volume: 249(5) Pages: 438-438
- Data Source
  KAKENHI-PROJECT-23791007
[Journal Article] Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease2014
- Author(s)
  Maheshwari, M., Bhutani, S., Das, A., Mukherjee, R., Sharma, A., Kino, Y., Nukina, N. & Jana, N.R.
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 23 Issue: 10 Pages: 2737-2751
- DOI
  10.1093/hmg/ddt667
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PROJECT-23791007, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25461299
[Journal Article] ハンチントン病の治療法開発とモデルマウスを用いた評価実験医学 in vivo2012
- Author(s)
  紀嘉浩、貫名信行
- Journal Title
  
  実験医学によるサイエンスと疾患解明
  
  Volume: Vol. 30 No. 2 (増刊) Pages: 203-210
- Data Source
  KAKENHI-PROJECT-23791007
[Journal Article] ハンチントン病の治療法開発とモデルマウスを用いた評価2012
- Author(s)
  紀嘉浩、貫名信行
- Journal Title
  
  実験医学増刊号｢in vivo実験医学によるヒト疾患解明の最前線｣
  
  Volume: 30 Pages: 203-210
- Data Source
  KAKENHI-PROJECT-23791007
[Journal Article] Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.2011
- Author(s)
  Kino Y, Washizu C, Aquilanti E, Okuno M, Kurosawa M, Yamada M, Doi H, Nukina N.
- Journal Title
  
  Nucleic Acids Research 39(7)
  
  Pages: 2781-2798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790854
[Journal Article] Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1.2011
- Author(s)
  Koebis M, Ohsawa N, Kino Y, Sasagawa N, Nishino I, Ishiura S.
- Journal Title
  
  Genes to Cells
  
  Volume: 16(9) Issue: 9 Pages: 961-972
- DOI
  10.1111/j.1365-2443.2011.01542.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791007
[Journal Article] Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 12011
- Author(s)
  Koebis M, Ohsawa N, Kino Y, Sasagawa N, Nishino I, Ishiura S
- Journal Title
  
  Genes to Cells
  
  Volume: 16(9) Pages: 961-972
- Data Source
  KAKENHI-PROJECT-23791007
[Journal Article] Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.2010
- Author(s)
  Kino, et al.
- Journal Title
  
  Nucleic Acids Research
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790854
[Journal Article] Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein.2010
- Author(s)
  Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G, Kino Y, Nagai Y, Nukina N.
- Journal Title
  
  Nature Biotechnologyz 28
  
  Pages: 256-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790854
[Journal Article] MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1.2009
- Author(s)
  Kino Y, Washizu C, Oma Y, Onishi H, Nezu Y, Sasagawa N, Nukina N, Ishiura S.
- Journal Title
  
  Nucleic Acids Research 37(19)
  
  Pages: 6477-6490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790854
[Journal Article] Inhibition of Rho kinases enhances the degradation of mutant huntingtin.2009
- Author(s)
  Bauer PO, Wong HK, Oyama F, Goswami A, Okuno M, Kino Y, Miyazaki H, Nukina N.
- Journal Title
  
  Journal of Biological Chemistry 284(19)
  
  Pages: 13153-13164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790854
[Journal Article] RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation.2009
- Author(s)
  Doumanis J, Wada K, Kino Y, Moore AW, Nukina N.
- Journal Title
  
  PLoS One 4(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790854
[Journal Article] MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN12009
- Author(s)
  Kino et al.
- Journal Title
  
  Nucleic Acids Research 37(19)
  
  Pages: 6477-6490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790854
[Journal Article] Expression of polyalanine stretches inducesmitochondrial dysfunction2008
- Author(s)
  鳥海和也、大間陽子、紀嘉浩、二井勇人、笹川昇、石浦章一
- Journal Title
  
  Journal of Neuroscience Research 86(7)
  
  Pages: 1529-1537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790620
[Journal Article] MBNL1 associates with YB-1 in cytoplasmic stress granules2008
- Author(s)
  大西隼、紀嘉浩、森田智子、二井勇人、笹川昇、石浦章一
- Journal Title
  
  Journal of Neuroscience Research 86(9)
  
  Pages: 1994-2002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790620
[Journal Article] Quantitative analysis of CUG-BP1 binding to RNA repeats2008
- Author(s)
  森大輔、笹川昇、紀嘉浩、石浦章一
- Journal Title
  
  Journal of Biochemistry 143(3)
  
  Pages: 377-383
- NAID
  10024908854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790620
[Journal Article] Interactions between homopolymeric amino acids (HPAAs)2007
- Author(s)
  大間陽子、紀嘉浩、鳥海和也、笹川昇、石浦章一
- Journal Title
  
  Protein Science 16(10)
  
  Pages: 2195-2204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790620
[Journal Article] Expression of MBNL and CELF mRNA transcripts in muscles with myotonic dystrophy2007
- Author(s)
  根津友理子、紀嘉浩、笹川昇、西野一三、石浦章一
- Journal Title
  
  Neuromuscular Disorder 17(4)
  
  Pages: 306-312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790620
[Presentation] 筋強直性ジストロフィー1型モデル細胞におけるMBNL1タンパク質の発現変動2023
- Author(s)
  青木祐賢、柳津茂慧、紀嘉浩
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07525
[Presentation] Regulatory factors of the formation of CUG repeat-containing RNA foci2023
- Author(s)
  Motoaki Yanaizu, Kai Nishimiya, Omi Toyama, Yoshitaka Aoki, Yoshihiro Kino
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07525
[Presentation] Identification of molecules that modulate RNA foci formation and/or MBNL activity2023
- Author(s)
  Yanaizu M, Nishimiya K, Toyama O, Aoki Y, Kino Y
- Organizer
  Myotonic Dystrophy Young Investigator Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07525
[Presentation] 脳疾患関連遺伝子TBC1D7の選択的スプライシング制御とその意義2023
- Author(s)
  土屋菜美、柳津茂慧、荒木信、紺谷圏二、紀嘉浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] TREM2の翻訳における5′非翻訳領域の役割2023
- Author(s)
  柳津茂慧、足立遥香、紀嘉浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] HNRNPA1によるCD33選択的スプライシングの制御とその進化的保存性2023
- Author(s)
  小室璃歩、本多由佳、柳津茂慧、長浜正巳、紀嘉浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] アルツハイマー病に関連したCD33選択的スプライシングの制御因子2022
- Author(s)
  小室璃歩、本多由佳、柳津茂慧、佐藤準一、紀嘉浩
- Organizer
  第45回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] Identification of NIPP1 as a modifier of RNA foci formation.2022
- Author(s)
  Nishimiya K, Toyama O, Yanaizu M, Kino Y
- Organizer
  The 13th International Myotonic Dystrophy Consortium Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07525
[Presentation] hnRNPファミリータンパク質によるアルツハイマー病リスク遺伝子CD33の制御2022
- Author(s)
  小室璃歩、本多由佳、柳津茂慧、佐藤準一、紀嘉浩
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] TREM2上流開始コドンによるTREM2の翻訳制御機構2022
- Author(s)
  柳津茂慧、足立遥香、佐藤準一、紀嘉浩
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] TREM2タンパク質アイソフォームの発現調節メカニズム2021
- Author(s)
  柳津茂慧、石井りさ、岩崎大輝、足立遥香、佐藤準一、紀嘉浩
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] TREM2 5' UTRを介した新規発現制御機構2021
- Author(s)
  柳津茂慧、足立遥香、佐藤準一、紀嘉浩
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] RNA-binding proteins that regulate genes associated with Alzheimer's disease2020
- Author(s)
  Yoshihiro Kino, Motoaki Yanaizu, Yuka Honda, Jun-ichi Satoh
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] アルツハイマー病関連遺伝子TREM2のRNA制御因子.2019
- Author(s)
  柳津茂慧、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第139年会 (2019)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] アルツハイマー病リスク遺伝子TREM2の種特異的な選択的スプライシング制御機構2019
- Author(s)
  柳津茂慧、紀嘉浩、佐藤準一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] In vitroおよび細胞内における蛍光性アプタマーを用いたリピートRNAの検出2019
- Author(s)
  紀嘉浩、正木泰行、河合美南、佐藤準一
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] アルツハイマー病リスク因子CD33のスプライシング制御因子の同定.2019
- Author(s)
  本多由佳、柳津茂慧、石野友基、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第139年会 (2019)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] TREM2の5’非翻訳領域によるタンパク質発現への影響.2019
- Author(s)
  足立遥香、佐藤準一、紀嘉浩、柳津茂慧.
- Organizer
  日本薬学会第139年会 (2019)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] ヌメリイグチ科担子菌類の産生するBACE1阻害活性物質の探索.2019
- Author(s)
  谷津元気、紀嘉浩、佐々木寛朗、高取和彦、木下薫、佐藤準一、小山清隆.
- Organizer
  日本薬学会第139年会 (2019)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 新規アルツハイマー病治療薬の創製：スチルベン誘導体の合成と構造活性相関.2019
- Author(s)
  安部隆蔵、木村真也、Natchanum Sirimangkalakitti, 紀嘉浩、佐藤準一、Veena Nukoolkarm, 斎藤直樹
- Organizer
  日本薬学会第139年会 (2019)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] アルツハイマー病リスク因子CD33のスプライシング制御因子の解析2019
- Author(s)
  本多由佳、柳津茂慧、紀嘉浩、佐藤準一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07982
[Presentation] GAジペプチドリピート凝集体と共局在するタンパク質の性状解析.2019
- Author(s)
  河合美南、滝谷美香、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第139年会 (2019)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] RNA biology of neurodegenerative diseases: Repeat expansion, splicing, and Alzheimer’s risk factors2019
- Author(s)
  Yoshihiro Kino
- Organizer
  35th International Annual Meeting in Pharmaceutical Sciences and CU-MPU International Collaborative Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09683
[Presentation] 培養細胞におけるBACE1阻害剤アッセイ系の樹立.2019
- Author(s)
  紀嘉浩、Natchanum Sirimangkalakitti,　石田ひかり、木下薫、斎藤直樹、小山清隆、佐藤準一.
- Organizer
  日本薬学会第139年会 (2019)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] GAジペプチドリピートおよびポリグルタミンと相互作用するタンパク質の解析2019
- Author(s)
  河合美南、紀嘉浩、佐藤準一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K09683
[Presentation] ダイレクトリプログラミングによる疾患モデル細胞系の樹立.2019
- Author(s)
  川口誠、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第139年会 (2019)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] In vitroおよび細胞内における蛍光性アプタマーを用いたリピートRNAの検出2019
- Author(s)
  紀嘉浩、正木泰行、河合美南、佐藤準一
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K09683
[Presentation] MicroRNA-Seq data analysis pipeline identifies blood biomarkers for Alzheimer’s disease.2018
- Author(s)
  Satoh J, Kino Y, Niida S.
- Organizer
  第57回日本神経学会学術大会 (2016)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 生物活性イソキノリン抗生物質を基軸とする新規認知症改善薬の創出.2018
- Author(s)
  Natchanum SIRIMANGKALAKITTI, 中井啓陽、山崎未来、紀嘉浩、佐藤準一、齋藤直樹.
- Organizer
  日本薬学会第138年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 改変型U1snRNAをもちいたTREM2那須ハコラ病関連スプライシング異常の矯正.2018
- Author(s)
  柳津茂慧、酒井健治、戸崎陽平、紀嘉浩、佐藤準一.
- Organizer
  第40回日本分子生物学会年会 (2017)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 蛍光アプタマーdBroccoliを用いたGGGGCCリピートRNAの可視化.2018
- Author(s)
  正木泰行、紀嘉浩、滝谷美香、佐藤準一.
- Organizer
  日本薬学会第138年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] RNAiベクターによる複数遺伝子の同時ノックダウン.2018
- Author(s)
  石野友基、三好潤子、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第138年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] アミロイドbetaの産生・凝集を評価するための培養細胞実験系の樹立.2018
- Author(s)
  石田ひかり、戸崎陽平、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第138年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 筋萎縮性側索硬化症・前頭側頭葉型認知症と関連するジペプチドリピート凝集体の解析.2018
- Author(s)
  滝谷美香、三好潤子、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第137年会 (2017)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] Dynamic changes in microglia along with progression of lesion stages in ALSP and Nasu-Hakola disease.2018
- Author(s)
  Oyanagi K, Kinoshita M, Satoh J, Ishihara K, Hasegawa K, Terada S, Yoshida M, Akiyama H, Mitsuyama Y, Ikeda S-I.
- Organizer
  World Congress of Neuropathology, WCN2018 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 那須ハコラ病の原因となるTREM2スプライス部位変異に対する治療分子.2018
- Author(s)
  紀嘉浩、柳津茂慧、佐藤準一.
- Organizer
  第40回日本神経科学大会 (2017)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 那須ハコラ病スプライス部位変異に対する新規治療アダプター分子の開発.2018
- Author(s)
  柳津茂慧、酒井健治、戸崎陽平、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第137年会 (2017)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] ウツロベニハナイグチのBACE1阻害活性物質の探索.2018
- Author(s)
  谷津元気、紀嘉浩、佐々木寛朗、木下薫、佐藤準一、小山清隆.
- Organizer
  日本薬学会第138年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] Identification of proteins sequestered by dipeptide repeat aggregates associated with ALS/FTD.2018
- Author(s)
  Kino Y, Taktani M, Satoh J.
- Organizer
  39th Annual Meeting of the Japan Neuroscience Society (2016)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] カラスタケ (Polyozellus multiplex) MeOHエキスからのAbeta凝集抑制活性物質の探索.2018
- Author(s)
  石倉彩香、荒幡一博、紀嘉浩、木下薫、佐藤準一、小山清隆.
- Organizer
  日本生薬学会第65年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] FUS/TLSによるPtk2b選択的スプライシング制御機構の解析.2018
- Author(s)
  酒井健治、戸崎陽平、柳津茂慧、木村美咲、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第137年会 (2017)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 新規アルツハイマー病治療薬の創製：スチルベン誘導体の合成と構造活性相関.2018
- Author(s)
  木村真也、安部隆蔵、Sirimangkalakitti Natchanun, 紀嘉浩、佐藤準一、齋藤直樹.
- Organizer
  日本薬学会第138年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 那須ハコラ病に関連したTREM2スプライシングの矯正.2018
- Author(s)
  柳津茂慧、酒井健治、戸崎陽平、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第138年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] C9orf72結合タンパク質Smcr8の機能の解析.2018
- Author(s)
  三好潤子、山本洋司、滝谷美香、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第137年会 (2017)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] RNA-Seqデータ解析によるMS in vivo IFNB-stimulated genesのプロフィール.2018
- Author(s)
  佐藤準一、酒井健治、戸崎陽平、柳津茂慧、紀嘉浩.
- Organizer
  第28回日本神経免疫学会学術集会 (2016)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] GGGGCCリピート由来細胞内凝集物の相互作用分子.2018
- Author(s)
  紀嘉浩、河合美南、正木泰行、佐藤準一.
- Organizer
  第41回日本分子生物学会年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 培養細胞におけるTREM2-DAP12相互作用検出系の構築.2018
- Author(s)
  戸崎陽平、酒井健治、柳津茂慧、成田由希美、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第137年会 (2017)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] ヌメリアイタケ(Albatrellus yaudae)CHCl3 ext.からのAbeta凝集抑制活性物質の探索.2018
- Author(s)
  秋庭愛、木下薫、紀嘉浩、佐藤準一、小山清隆.
- Organizer
  日本薬学会第138年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] ウツロベニハナイグチ (Boletinus asiaticus)の新規メルテルペノイドのBACE1阻害活性.2018
- Author(s)
  谷津元気、紀嘉浩、佐々木寛朗、高取和彦、木下薫、佐藤準一、小山清隆.
- Organizer
  日本生薬学会第65年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] CRISPR/CAS9による那須ハコラ病DNA変異修復を目指したレポーター細胞系の検討.2018
- Author(s)
  大槻絢彩、戸崎陽平、柳津茂慧、紀嘉浩、佐藤準一.
- Organizer
  日本薬学会第138年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 新規アルツハイマー病治療薬の創製：スチルベン誘導体の合成と構造活性相関.2018
- Author(s)
  安部隆蔵、木村真也、Natchanum Sirimangkalakitti, 紀嘉浩、佐藤準一、Veena Nukoolkarm, 斎藤直樹.
- Organizer
  第22回天然薬物の開発と応用シンポジウム. (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and Nasu-Hakola disease. Lesion staging and dynamic changes of axons and microglial subsets.2018
- Author(s)
  Oyanagi K, Kinoshita M, Nakahara A, Satoh J, Aoki N, Jinnai K, Yazawa I, Arai K, Ishihara K, Kawamura M, Arai N, Hasegawa K, Yagishita S, Amano N, Yoshida K, Terada S, Yoshida M, Akiyama H, Mitsuyama Y, Ikeda S.
- Organizer
  XXIIIrd World Congress of Neurology (2017)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] GGGGCCリピート由来細胞内凝集物の相互作用分子2018
- Author(s)
  紀嘉浩、河合美南、正木泰行、佐藤準一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K09683
[Presentation] ヌメリアイタケ (Albatrellus yasudae) CHCl3 ext. からのAbeta凝集抑制活性物質の探索.2018
- Author(s)
  秋庭愛、木下薫、紀嘉浩、佐藤準一、小山清隆.
- Organizer
  日本生薬学会第65年会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] TREM2の選択的スプライシングと那須ハコラ病関連変異によるその異常.2018
- Author(s)
  紀嘉浩、柳津茂慧、酒井健治、戸崎陽平、佐藤準一.
- Organizer
  第41回日本神経科学大会 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 蛍光性アプタマーを用いた神経疾患関連リピートRNAの可視化.2018
- Author(s)
  紀嘉浩、正木泰行、滝谷美香、佐藤準一.
- Organizer
  第40回日本分子生物学会年会 (2017)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] Expression of GPR17, a negative regulator of oligodendrocyte differentiation and maturation, in Nasu-Hakola disease brains.2018
- Author(s)
  Satoh J, Kino Y, Ishida T, Saito Y.
- Organizer
  World Congress of Neuropathology, WCN2018 (2018)
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 那須ハコラ病の原因となるTREM2スプライス部位変異に対する治療分子.2017
- Author(s)
  紀嘉浩、柳津茂慧、佐藤準一
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and Nasu-Hakola disease. Lesion staging and dynamic changes of axons and microgial subsets.2017
- Author(s)
  Oyanagi K, Kinoshita M, Nakahara A, Satoh J, Aoki N, Jinnai K, Yazawa I, Arai K, Ishihara K, Kawamura M, Arai N, Hasegawa K, Yagishita S, Amano N, Yoshida K, Terada S, Yoshida M, Akiyama H, Mitsuyama Y, Ikeda S
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] FUS/TLSによるPtk2b選択的スプライシング制御機構の解析.2017
- Author(s)
  酒井健治、戸崎陽平、柳津茂慧、木村美咲、紀嘉浩、佐藤準一
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] C9orf72結合タンパク質Smcr8の機能の解析.2017
- Author(s)
  三好潤子、山本洋司、滝谷美香、紀嘉浩、佐藤準一
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 筋萎縮性側索硬化症・前頭側頭葉型認知症と関連するジペプチドリピート凝集体の解析.2017
- Author(s)
  滝谷美香、三好潤子、紀嘉浩、佐藤準一
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 6.那須ハコラ病の原因となるTREM2スプライス部位変異に対する治療分子2017
- Author(s)
  紀嘉浩、柳津茂慧、佐藤準一
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K09683
[Presentation] RNA結合タンパク質FUS/TLSの機能低下と神経疾患2017
- Author(s)
  紀嘉浩
- Organizer
  第19回応用薬理シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K09683
[Presentation] 7.蛍光性アプタマーを用いた神経疾患関連リピートRNAの可視化2017
- Author(s)
  紀嘉浩、正木泰行、滝谷美香、佐藤準一
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K09683
[Presentation] 那須ハコラ病スプライス部位変異に対する新規治療アダプター分子の開発.2017
- Author(s)
  柳津茂慧、酒井健治、戸崎陽平、紀嘉浩、佐藤準一
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 蛍光性アプタマーを用いた神経疾患関連リピートRNAの可視化.2017
- Author(s)
  紀嘉浩、正木泰行、滝谷美香、佐藤準一
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 改変型U1snRNAを用いたTREM2那須ハコラ病関連スプライシング異常の矯正.2017
- Author(s)
  柳津茂慧、酒井健治、戸崎陽平、紀嘉浩、佐藤準一
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] 培養細胞におけるDAP12相互作用検出系の構築.2017
- Author(s)
  戸崎陽平、酒井健治、柳津茂慧、成田由希美、紀嘉浩、佐藤準一
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] MicroRNA-Seq data analysis pipeline identifies blood biomarkers for Alzheimer's disease.2016
- Author(s)
  Satoh J, Kino Y, Niida S
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] Genetic effetcs of FUS/TLS heterozygous deletion on polyglutamine disease model mice2016
- Author(s)
  Kino Y, Washizu C, Kurosawa M, Yamada M, Doi H, Takumi T, Adachi H, Katsuno M, Sobue G, Geoffrey G. Hicks GG, Hattori N, Shimogori T, Nukina N.
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25461299
[Presentation] RNA-Seqデータ解析によるMS in vivo IFNB-stimulated genesのプロフィール.2016
- Author(s)
  佐藤準一、酒井健治、戸崎陽平、柳津茂慧、紀嘉浩
- Organizer
  第28回日本神経免疫学会学術集会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-16K07043
[Presentation] Identification of proteins sequestered by dipeptide repeat aggregates associated with ALS/FTD2016
- Author(s)
  Kino Ｙ, Takitani M, Miyoshi J, Satoh J
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-16K09683
[Presentation] Protein/RNA aggregation in neurological disorders2013
- Author(s)
  Kino Y, Nukina N
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23791007
[Presentation] Nuclear localization of MBNL1 : Implications for splicing-mediated autoregulation and expanded repeat-related protein expression2011
- Author(s)
  Kino Y, Washizu C, Kurosawa M, Oma Y, Ishiura S, Nukina N
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-23791007
[Presentation] Nuclear Localization of MBNL1: Implications for splicing-mediated autoregulation and expanded repeat-related protein expression2011
- Author(s)
  Yoshihiro Kino, Chika Washizu, Masaru Kurosawa, Yoko Oma, Shoichi Ishiura, Nobuyuki Nukina
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23791007
[Presentation] RNA結合タンパク質MBNL1によるリピート伸長疾患RNAの制御2011
- Author(s)
  紀嘉浩、鷲頭知花、黒澤大、貫名信行
- Organizer
  包括型脳科学研究推進支援ネットワーク　夏のワークショップ
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23791007
[Presentation] Muscleblind proteins repress aberrant protein expression derived from expanded repeats2011
- Author(s)
  Kino Y, Washizu C, Kurosawa M, Oma Y, Ishiura S, Nukina N
- Organizer
  8th International Myotonic Dystrophy Consortium Meeting
- Place of Presentation
  タンパ(米国)
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23791007
[Presentation] 筋萎縮性側索硬化症に関連する変異はFUS/TLSの細胞内局在およびスプライシング制御能に影響する2011
- Author(s)
  紀嘉浩、鷲頭知花、奥野弥佐子、黒澤大、山田みず樹、土井宏、貫名信行
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-23791007
[Presentation] 筋萎縮性側索硬化症に関連する変異はFUS/TLSの細胞内局在およびスプライシング制御に影響する2011
- Author(s)
  紀嘉浩、鷲頭知花、奥野弥佐子、黒沢大、山田みず樹、土井宏、貫名信行
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23791007
[Presentation] RNA結合タンパク質MBNL1によるリピート伸長疾患RNAの制御2011
- Author(s)
  紀嘉浩、鷲頭知花、黒澤大、貫名信行
- Organizer
  包括型脳科学推進支援ネットワーク夏のワークショップ
- Place of Presentation
  神戸
- Year and Date
  2011-08-23
- Data Source
  KAKENHI-PROJECT-23791007
[Presentation] Muscleblind proteins repress aberrant protein expression derived from expanded repeats2011
- Author(s)
  Yoshihiro Kino, Chika Washizu, Masaru Kurowasa, Yoko Oma, Shoichi Ishiura, Nobuyuki Nukina
- Organizer
  8th International Myotonic Dystrophy Consortium Meeting
- Place of Presentation
  タンパ
- Data Source
  KAKENHI-PROJECT-23791007
[Presentation] The effects of ALS-linked mutations of FUS/TLS2010
- Author(s)
  Kino, et al.
- Organizer
  第1回新潟大学脳研究所共同研究拠点国際シンポジウムCurrent Understandings and Future Directions for ALS
- Place of Presentation
  新潟
- Year and Date
  2010-11-22
- Data Source
  KAKENHI-PROJECT-21790854
[Presentation] Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.2010
- Author(s)
  Kino, et al.
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会(BMB2010)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790854
[Presentation] Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.2010
- Author(s)
  Kino, et al.
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会(BMB2010)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790854
[Presentation] RNA結合タンパク質TLS/FUSの機能と神経変性疾患との関連2010
- Author(s)
  Kino, et al.
- Organizer
  包括脳ネットワーク夏のワークショップ
- Place of Presentation
  札幌
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-21790854
[Presentation] RNA結合タンパク質TLS/FUSの機能と神経変性疾患との関連2010
- Author(s)
  Kino, et al.
- Organizer
  包括脳ネットワーク夏のワークショップ
- Place of Presentation
  札幌
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-21790854
[Presentation] The effects of ALS-linked mutations of FUS/TLS第1回新潟大学脳研究所共同研究拠点国際シンポジウム2010
- Author(s)
  Kino, et al.
- Organizer
  Current Understandings and Future Directions for ALS
- Place of Presentation
  新潟
- Year and Date
  2010-11-22
- Data Source
  KAKENHI-PROJECT-21790854
[Presentation] Autoregulation of MBNL1 : coupling of splicing regulatory activity and intracellular localization2009
- Author(s)
  紀嘉浩
- Organizer
  7th International Myotonic Dystrophy Consortium Meeting
- Place of Presentation
  ヴュルツブルク(ドイツ)
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21790854
[Presentation] 疾患に関連したMBNL1のスプライシング制御2009
- Author(s)
  紀嘉浩
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21790854
[Presentation] Cell-based analysis of splicing regulation by MBNL proteins2008
- Author(s)
  紀嘉浩
- Organizer
  Therapeutic Strategies for Myotonic Dystrophy Workshop
- Place of Presentation
  カナダ、バンフ
- Year and Date
  2008-08-15
- Data Source
  KAKENHI-PROJECT-19790620
[Presentation] Cell-based analysis of splicing regulation by MBNL proteins2008
- Author(s)
  紀嘉浩
- Organizer
  Therapeutic Strategies for Myotonic Dystrophy Workshop
- Place of Presentation
  バンフ(カナダ)
- Year and Date
  2008-08-15
- Data Source
  KAKENHI-PROJECT-19790620
[Presentation] Structural determinants for the molecular properties of MBNL proteins2007
- Author(s)
  Yoshihiro Kino, et. al.
- Organizer
  6th Internation Myotonic Dystrophy Consortium Meeting
- Place of Presentation
  ミラノ(イタリア)
- Year and Date
  2007-09-14
- Data Source
  KAKENHI-PROJECT-19790620
[Presentation] Structural determinants for the molecular properties of MBNL proteins2007
- Author(s)
  紀嘉浩(代表者)
- Organizer
  6th International Myotonic Dystrophy Consortium Meeting
- Place of Presentation
  ミラノ(イタリア)
- Year and Date
  2007-09-14
- Data Source
  KAKENHI-PROJECT-19790620
[Presentation] Protein/RNA aggregation in neurological disorders
- Author(s)
  Yoshihiro Kino, Nobuyuki Nukina
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-23791007
[Presentation] 病態制御因子としてのポリグルタミン凝集体結合タンパク質
- Author(s)
  紀嘉浩、貫名信行
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-25461299

1. Satoh Jun-ichi (30274591)

# of Collaborated Projects: 2 results

# of Collaborated Products: 54 results
2. 柳津茂慧 (20913362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
3. 土井宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 貫名信行

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. 小山文隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 河村満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 下郡智美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 山中智行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kino Yoshihiro 紀 嘉浩

KINO Yoshihiro 紀 嘉浩

Research Projects

Research Products

Co-Researchers

GGCリピート伸長疾患における核内封入体の形成機構とMBNL1の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

リピートRNA封入体の形成・分解に関わる新規遺伝子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular Pathology and Therapeutic Approach in Nasu-Hakola Disease

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RNA-binding proteins that regulate microglial genes associated with neurological diseasesPrincipal Investigator

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Elucidation of Molecular Pathogenesis of Nasu-Hakola Disease

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A common interactor of protein aggregates associated with ALS/FTD and polyglutamine diseasesPrincipal Investigator

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Loss of function of FUS/TLS in normal and pathological conditionsPrincipal Investigator

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RNA metabolism and RNA-binding proteins in polyglutamine diseasesPrincipal Investigator

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Roles of an RNA-binding protein MBNL1 in polyglutamine diseasesPrincipal Investigator

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The expression and effects of aberrant RNAs in repeat expansion disordersPrincipal Investigator

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[Book] Molecular Mechanisms of Myotonic Dystrophy: RNA-Mediated Pathogenesis and RNA-Binding Proteins. In Myotonic Dystrophy. Disease Mechanism, Current Management and Therapeutic Development.2018

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[Book] Myotonic Dystrophy (edited by ed by Takahashi MP, Matsumura T)2018

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[Book] モデル動物実験マニュアル 疾患モデルの作成と利用 脳・神経疾患 (第2節 ハンチントン病モデルマウス)2011

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Kino Yoshihiro 紀嘉浩

KINO Yoshihiro 紀嘉浩

[Book] モデル動物実験マニュアル　疾患モデルの作成と利用　脳・神経疾患　(第2節ハンチントン病モデルマウス)2011

[Book] 実験医学 (増刊) 脳神経疾患の分子病態と治療への展開「神経筋疾患とRNA代謝異常」2007

[Journal Article] Reactive astrocytes express Aggregatin (<i>FAM222A</i>) in the brains of Alzheimer's disease and Nasu-Hakola disease2020

[Journal Article] Microglia express GPNMB in the brains of Alzheimer's disease and Nasu-Hakola disease2019