HISAKA Akihiro 樋坂章博

… Alternative Names

樋口章博ヒサカアキヒロ

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Researcher Number	80420206
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2023: 千葉大学, 大学院薬学研究院, 教授 2016 – 2019: 千葉大学, 大学院薬学研究院, 教授 2014 – 2015: 千葉大学, 薬学研究科(研究院), 教授 2014: 千葉大学, 大学院薬学系研究科, 教授 2011 – 2013: 東京大学, 医学部附属病院, 准教授 … More 2009 – 2012: The University of Tokyo, 医学部附属病院, 特任准教授 2008: 東京大学, 医学部・附属病院, 客員准教授 2007 – 2008: The University of Tokyo, 医学部・附属病院, 特任准教授 2007: 東京大学, 医学部附属病院, 客員准教授 2007: The University of Tokyo, The University of Tokyo Hospital, project associate professor 2006: 東京大学, 医学部附属病院, 講師 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Drug development chemistry / Laboratory medicine Except Principal Investigator Medical pharmacy / Basic Section 48030:Pharmacology-related / Applied pharmacology / Pain science / Complex systems
Keywords	Principal Investigator 薬物動態 / 臨床 / 薬剤反応性 / 蛋白質 / トランスレーショナルリサーチ / 医療・福祉 / absorption / pharmacokinetics / modeling and simulation / analysis, evaluation … More / トランスポーター / モデル化 / 吸収 / モデル化とシミュレーション / 解析・評価 / 薬物血中濃度 / 生理学的薬物速度論 / 臨床試験 / クリアランス / モデリング / LC-MS/MS / DBS / 薬物動態学 / 小児薬用量 / 療・福祉 / 炎症性サイトカイン / 薬剤性肝障害 / 医薬品化学 / トランスレーショナル・リサーチー / 医療、福祉 … More Except Principal Investigator メタボローム / 代謝 / 薬物動態 / 薬理学 / 癌 / 薬剤反応性 / ケトン体 / 炎症 / 糖尿病 / 心血管イベントリスク / マクロファージ / 脂肪細胞 / SGLT2阻害薬 / 数理モデル / PK-PD / モデル基盤メタ・アナリシス / 第 Xa 因子阻害 / 心房細動 / 大出血 / 脳梗塞 / PT-INR / PK/PDモデル / 大規模臨床試験 / PPK/PDモデル / 血栓形成 / 用量最適化 / 血流量 / プロトロンビン時間 / PK-PDモデル / PPK-PDモデル / イベントリスク / モデル基盤メタアナリシス / 第Xa因子阻害剤 / CE-TOFMS / HDAC阻害薬 / 血管新生阻害薬 / 薬物感受性 / スニチニブ / トリコスタチンA / エピジェネティクス / 酸化的リン酸化 / チロシンキナーゼ阻害薬 / ヒストン脱アセチル化酵素阻害薬 / 腎細胞がん / 薬物耐性 / エピジェネティック調節 / 細胞内代謝 / 皮膚炎 / ヒスタミン / 乾癬 / イミキモド（IMQ） / 肥厚スコア / 耳介腫脹スコア / H4受容体アンタゴニスト / H4R KOマウス / NGF mRNA / イミキモド（IMQ）乾癬マウス / H4受容体アンタゴニス / Preproenkephalin / TSLP / NGF / 掻破回数 / Preproenkephalin (PPE) / Neurotrophin 3 (NT3) / Nerve growth factor / Mast cell protease-6 / マスト細胞 / SCLABA-Real / 掻痒 / イミキモド（IMQ）誘発乾癬モデルマウス / ＰＥＴ / トランスポーター / 代謝酵素 / 階層構造 / スケーリングファクター / 肝異物解毒システム / トランスロケーションモデル / クラスターニュートン法 / 代謝物 / 薬物間相互作用 / 薬物動態学 / cluster newton method / 生理学的モデル / PET / 体内動態予測 / 体内動態 / 毒性 / 薬物体内動態 / RANKL / 双方向シグナル / 破骨細胞 / 骨芽細胞 / 骨粗鬆症 / 生体分子 / 発現制御 / シグナル伝達 / オフ・ターゲット / 分子標的薬 / キナーゼ / 毒性学 / モデル / シミュレーション / 感染症 / 個人差 Less

Significance of ketone body metabolic shift in diabetes and long-term prognosis prediction
- Principal Investigator
  
  Sato Hiromi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Chiba University
Model based meta-analysis and establishment of PBPK model for appropriate use of factor Xa inhibitor
- Principal Investigator
  
  Sato Hiromi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Expression of precipitating factors of pruritus found in humans in an imiquimodinduced psoriasis mouse model
- Principal Investigator
  
  Yamaura Katsunori
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Keio University
Epigenetic regulation shifted cellular metabolism of cancer cells, which contributed to potentiate drug sensitivity of antiangiogenic agents.
- Principal Investigator
  
  Sato Hiromi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Chiba University
Development of Micro-blood-sampling Method for Pharmacokinetic Analysis in Clinical StudiesPrincipal Investigator
- Principal Investigator
  
  HISAKA Akihiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
  The University of Tokyo
Comprehensive analysis of the factors regulating the disposition of small molecules at organ and tissue levels
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Research on Drug-Induced Liver Injury Associated with MetabolicActivation by CYPPrincipal Investigator
- Principal Investigator
  
  HISAKA Akihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Physiological situation based prediction of the adverse effects associated with molecularly-targeted drugs.
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
抗血小板薬の標的酵素あるいは受容体の修飾を検出するバイオマーカーによる薬効評価Principal Investigator
- Principal Investigator
  
  樋坂章博
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokyo
Establishment of quantitative prediction method for the individual variabilities in hematologic toxicity of anti-cancer agents
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Systematic analysis of intestinal absorption process considering drug transportation across membranesPrincipal Investigator
- Principal Investigator
  
  HISAKA Akihiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo

[Book] 代謝酵素,トランスポーターによる薬物間相互作用,個人間変動が薬効、副作用に与える影響の解析:創薬科学の魅力-東京大学大学院薬学系研究科からの発信2010
- Author(s)
  樋坂章博, 鈴木洋史
- Total Pages
  21
- Publisher
  広川書店
- Data Source
  KAKENHI-PROJECT-21659145
[Book] Principles of pharmacokinetics : Predicting human pharmacokinetics in drug discovery. in "Mass Spectrometry in Drug Metabolism and Disposition : Basic Principles and Applications"2010
- Author(s)
  Yamamoto T, Hisaka A, Suzuki H.
- Publisher
  John Wiley & Sons(in press)
- Data Source
  KAKENHI-PROJECT-21659145
[Book] 最新創薬学2007(非臨床データから臨床データへのブリッジング)2007
- Author(s)
  樋坂章博
- Total Pages
  6
- Publisher
  メディカルドゥ
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590135
[Book] 最新創薬学、非臨床データから臨床データへのブリッジング2007
- Author(s)
  樋坂章博
- Total Pages
  6
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-18590135
[Book] 創薬動態-医薬品創製のための考え方と最新情報-(V:臨床薬物動態)2006
- Author(s)
  鈴木洋史, 伊藤晃成, 樋坂章博
- Total Pages
  14
- Publisher
  日本薬物動態学会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590135
[Journal Article] Model-based meta-analysis to evaluate optimal doses of direct oral factor Xa inhibitors in atrial fibrillation patients2018
- Author(s)
  Yoshioka H, Sato H, Hatakeyama H, Hisaka H
- Journal Title
  
  Blood Advances
  
  Volume: 2(10) Issue: 10 Pages: 1066-1075
- DOI
  10.1182/bloodadvances.2017013805
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08436
[Journal Article] A new physiologically based pharmacokinetic model for the prediction of gastrointestinal drug absorption: translocation model2015
- Author(s)
  Ando H, Hisaka A, Suzuki H
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 43 Issue: 4 Pages: 590-602
- DOI
  10.1124/dmd.114.060038
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136015, KAKENHI-PLANNED-23136101
[Journal Article] 薬物動態解析プログラムNaPPの紹介2011
- Author(s)
  樋坂章博
- Journal Title
  
  薬剤学
  
  Volume: 2011 Pages: 168-178
- NAID
  10029415959
- Data Source
  KAKENHI-PROJECT-22390020
[Journal Article] Theoretical considerations on quantitative prediction of drug-drug Interactions2010
- Author(s)
  Hisaka A, Ohno Y, Yamamoto T, Suzuki H.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 25
  
  Pages: 48-61
- NAID
  10027581845
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590135
[Journal Article] PK-PD理論に基づいた医薬品評価のポイント2010
- Author(s)
  樋坂章博
- Journal Title
  
  月刊薬事
  
  Volume: 11月臨時増刊号 Pages: 15-20
- Data Source
  KAKENHI-PROJECT-21659145
[Journal Article] 相互作用情報とマネジメント2010
- Author(s)
  樋坂章博
- Journal Title
  
  月刊薬事
  
  Volume: 11月臨時増刊号 Pages: 85-90
- Data Source
  KAKENHI-PROJECT-21659145
[Journal Article] Theoretical considerations on quantitative prediction of drug-drug Interactions2010
- Author(s)
  Hisaka A, Ohno Y, Yamamoto T, Suzuki H
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 25
  
  Pages: 48-61
- NAID
  10027581845
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590135
[Journal Article] Theoretical considerations on quantitative prediction of drug-drug Interactions.2010
- Author(s)
  Hisaka A, Ohno Y, Yamamoto T, Suzuki H
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 25 Pages: 48-61
- NAID
  10027581845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390020
[Journal Article] Prediction of pharmacokinetic drug-drug interaction caused by changes in cytochrome P450 activity using in vivo information2010
- Author(s)
  Hisaka A, Ohno Y, Yamamoto T, Suzuki H
- Journal Title
  
  Pharmacol.Ther 125
  
  Pages: 230-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659145
[Journal Article] Analysis of pharmacokinetic data provided in Japanese package inserts and interview forms focusing on urinary excretion of pharmacologically active species2006
- Author(s)
  Ohno Y, Kusama M, Hisaka A, Yanagihara Y, Suzuki H.
- Journal Title
  
  Yakugaku Zasshi 126(7)
  
  Pages: 489-94
- NAID
  110006154961
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590135
[Journal Article] Analysis of pharmacokinetic data provided in Japanese package inserts and interview forms focusing on urinary excretion of pharmacologically active species.2006
- Author(s)
  Ohno Y, Kusama M, Hisaka A, Yanagihara Y, Suzuki H
- Journal Title
  
  Yakugaku Zasshi 126(7)
  
  Pages: 489-94
- NAID
  110006154961
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590135
[Presentation] 転移性脳腫瘍から発信されるcGAMPがアストロサイトの代謝に与える影響の速度論的評価2023
- Author(s)
  菊池望恵、吉友葵、小金正空、後藤杏子、大川柊弥、原来実、白根大貴、松本千佳、田中浩揮、秋田英万、樋坂章博、佐藤洋美
- Organizer
  第143回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-21K06797
[Presentation] 機械学習による糖尿病の長期病態進行モデルの構築とイベントリスク解析2023
- Author(s)
  佐野大和, 神亮太, 佐藤洋美, 樋坂章博
- Organizer
  第44回日本臨床薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06797
[Presentation] SGLT2阻害剤による脂肪組織の炎症抑制および代謝シフトに関する検討2023
- Author(s)
  佐藤洋美、豊島拓斗、小金正空、井澤　涼、樋坂章博
- Organizer
  次世代を担う若手のための創薬・医療薬理シンポジウム2023
- Data Source
  KAKENHI-PROJECT-21K06797
[Presentation] SGLT2阻害剤による心保護作用のメカニズム解明のための脂肪組織の抗炎症及び代謝シフトに関する検討2023
- Author(s)
  豊島拓斗、小金正空、樋坂章博、佐藤洋美
- Organizer
  第148回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-21K06797
[Presentation] Role of astrocytes in building tumor microenvironment around metastatic brain tumors.2022
- Author(s)
  Sato H, Goto M, Kato K, Sato K, Okawa T, Kikuchi M, Usuki K, Tanaka H, Matsumoto C, Akita H, Hisaka A.
- Organizer
  The 24th Japan-Korea Joint Seminar on Pharmacology
- Invited
- Data Source
  KAKENHI-PROJECT-21K06797
[Presentation] 脂肪細胞におけるSGLT2阻害薬の代謝調節および抗炎症作用の連関2022
- Author(s)
  小金正空、豊島拓斗、加藤大皓、後藤杏子、樋坂章博、佐藤洋美
- Organizer
  第142回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-21K06797
[Presentation] cGAMP導入がアストロサイトのグルタミン酸関連物質の代謝フラックスに与える影響2022
- Author(s)
  菊池望恵、吉友葵、後藤杏子、白根大貴、田中浩揮、秋田英万、樋坂章博、佐藤洋美
- Organizer
  生体機能と創薬シンポジウム2022
- Data Source
  KAKENHI-PROJECT-21K06797
[Presentation] Investigation of Adipose Tissue Inflammation to Elucidate the Mechanism of Cardioprotective Effects of SGLT2 Inhibitors.2022
- Author(s)
  Toyoshima T, Kogane M, Kikuchi M, Hisaka A, Sato H
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06797
[Presentation] SGLT2阻害薬Dapagliflozinが脂肪細胞のメタボロームに与える影響2021
- Author(s)
  小金正空、豊島拓斗、後藤杏子、樋坂章博、佐藤洋美
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K06797
[Presentation] Utilizing Machine Learning in Analysis of Megatrials; A Combined Analysis of the OASIS-5 and -6 Trials Using Individual Patient Data2020
- Author(s)
  Yoshioka H, Sato H, Hisaka A
- Organizer
  Pharmacometrics Japan Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] 血流量変化を活用したFXa阻害薬の抗凝固作用に関するPK-PDモデルの構築2019
- Author(s)
  藤田菜生, 吉岡英樹, 佐藤洋美, 樋坂章博
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2019
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] 機械学習は臨床試験の解析にどの程度使えるのか：複数臨床試験に由来する仮想大規模個人データについて非線形混合効果モデルによる解析との比較2019
- Author(s)
  吉岡英樹, 佐藤洋美, 樋坂章博
- Organizer
  第139回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] 母集団薬物動態解析における機械学習の有用性評価：非線形混合効果モデル(NONMEM)との比較2019
- Author(s)
  吉岡英樹, 佐藤洋美, 畠山浩人, 樋坂章博
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] Utility of Machine Learning in Population Pharmacokinetic or Pharmacodynamic Analysis2019
- Author(s)
  Yoshioka H, Sato H, Hisaka A
- Organizer
  JKPW2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] 複数臨床試験に由来する大規模個人データの統合解析方法の研究：非線形混合効果モデル2018
- Author(s)
  吉岡英樹, 佐藤洋美, 樋坂章博
- Organizer
  第4回次世代を担う若手のためのレギュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] 抗凝固薬の死亡リスクに対する様々な出血評価基準の有用性の解析 -直接経口第Xa因子阻害剤の大規模臨床試験のモデル基盤メタ・アナリシス-2018
- Author(s)
  吉岡英樹, 佐藤洋美, 樋坂章博
- Organizer
  第18回国際薬理学・臨床薬理学会議(WCP2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] Simulation study comparing non-linear mixed-effect modeling and machine learning: efficient integration of individual patient-level data from multiple clinical trials2018
- Author(s)
  Hideki Yoshioka, Hiromi Sato, Akihiro Hisaka
- Organizer
  情報計算化学生物学会(CBI)2018年会
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] Integrated use of in vitro and In vivo data for systetematic prediction of drug-drug interactions caused by inhibitions of multiple CYP species by Markov Chain Monte Carlo Method.2018
- Author(s)
  Hozuki S, Yshioka H, Sato H, Hisaka A.
- Organizer
  ASCPT2018 Meeting
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] 平成 29 年度人工知能等関連研究支援プログラム千葉大学 AI 研究会（第 1 回）2018
- Author(s)
  佐藤洋美, 保月静香, 吉岡英樹, 浅野聡志, 樋坂章博
- Organizer
  異種情報を統合したモデル解析のデータ駆動型最適化
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] 臨床試験早期における薬効予測を指向したSGLT2阻害薬6剤の尿糖排泄量とHbA1c変化のモデル基盤メタアナリシス2018
- Author(s)
  石川彩夏、佐藤洋美、吉岡英樹、樋坂章博．
- Organizer
  第138回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] Induction of intestinal Cyp3a by intake of calcitriol, an active form of vitamin D, in rats breed with vitamin D free diet.2018
- Author(s)
  Hisaka A, Takatsu T, Sato H.
- Organizer
  ASCPT2018 Meeting
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] A new integration method of in vitro and in vivo information for systematic prediction of drug-drug interactions caused by inhibitions of multiple CYP species2017
- Author(s)
  Hozuki S, Yoshioka H, Sato H, Hisaka A.
- Organizer
  第33回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] モデル基盤メタ・アナリシスに基づく第Xa因子阻害剤の至適用量の推定2017
- Author(s)
  吉岡英樹、畠山浩人、佐藤洋美、樋坂章博
- Organizer
  第39回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] イミキモド誘発乾癬モデルマウスにおける掻破行動解析および掻痒誘発関連因子の探索2017
- Author(s)
  大石信雄、岩田紘樹、小林典子、藤本和子、佐藤洋美、樋坂章博、山浦克典
- Organizer
  2017年日本免疫毒性学会　第24回年会
- Data Source
  KAKENHI-PROJECT-15K08666
[Presentation] Noticeable induction of intestinal Cyp3a via vitamin D receptor in rats breed with vitamin D free diet2017
- Author(s)
  Sato H, Ochiai M, Takatsu T, Hisaka A.
- Organizer
  第33回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] アゾール系抗真菌薬の阻害するCYP分子種の検討2017
- Author(s)
  佐藤洋美、保月静香、吉岡英樹、柴田侑裕、樋坂章博
- Organizer
  第38回日本臨床薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08436
[Presentation] トリコスタチンAはエピジェネティック調節により腎細胞がんの代謝を変化させる．2017
- Author(s)
  佐藤洋美, 藤原拓也, 畠山浩人, 加柴達朗, 宇津美秋, 上野光一, 樋坂章博.
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K19161
[Presentation] トリコスタチンＡによる腎細胞がんのスニチニブ感受性増強と代謝調節の関与．2016
- Author(s)
  佐藤洋美, 加柴達朗, 藤原拓也, 宇津美秋, 樋坂章博．
- Organizer
  第10回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  前橋
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15K19161
[Presentation] Cotreatment of trichostain A enhances cytotoxic effects of sunitinib in human renal cell carcinoma cells.2016
- Author(s)
  加柴達朗、佐藤洋美、宇津美秋、柴田侑裕、藤原拓也、樋坂章博．
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K19161
[Presentation] Topical application of DP1 agonist effectively prevents pruritus induced by long-term treatment of glucocorticoids in allergic contact dermatitis mice.2015
- Author(s)
  Ayaka Funakoshi, Katsunori Yamaura, Seiji Onuma, Riho Tanaka, Misako Takei, Naotomo Kambe, Hiromi Sato, Akihiro Hisaka.
- Organizer
  8th World Congress on Itch.
- Place of Presentation
  Nara Kasugano International Forum IRAKA, Nara, Japan
- Year and Date
  2015-09-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08666
[Presentation] Combined treatment of trichostatin A enhances cytotoxic effects of sunitinib on renal cell carcinoma cells.2015
- Author(s)
  Sato,H.,Kashiba,T.,Uzu,M.,Fujiwara,T.,Shibata,Y.,Suzuki,R.,Yamaura,K.,Hisaka,A.
- Organizer
  American Association for Cancer Research ANNUAL MEETING 2015
- Place of Presentation
  Philadelphia, PA, USA
- Year and Date
  2015-04-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19161
[Presentation] 創薬および医療におけるモデリング・シミュレーションの活用2014
- Author(s)
  樋坂章博
- Organizer
  千葉大学未来医療教育研究機構シンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-07-26
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 臨床を予測するためのモデリングの挑戦2014
- Author(s)
  樋坂章博
- Organizer
  第4回　杉山特別研究室（理研）公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-09-25
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] レギュラトリーサイエンスにおけるモデリング＆シミュレーションの役割2014
- Author(s)
  樋坂章博
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-25670070
[Presentation] Science Based Management of Drug Interactions2013
- Author(s)
  Hisaka A
- Organizer
  The First International Conference of Sugiyama Laboratory
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Meta-analysis of Ethnic Differences in Oral Clearance between Western and Japanese: Comparison among Various Clearance Pathways2013
- Author(s)
  Hisaka A, Matsunami R, Suzuki H
- Organizer
  American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition
- Place of Presentation
  San Antonio, USA
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Quantification of Cytochrome P450s and Nuclear Receptors in Primary 3D-Culture Mouse Hepatocyte by LC-MS/MS2012
- Author(s)
  Sasaki Y, Hisaka A, Suzuki H
- Organizer
  1st HD Physiology International Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] CYPの発現量の個人間変動モテ□リング(講演)2011
- Author(s)
  樋坂章博
- Organizer
  CBI学会第314回研究講演会
- Place of Presentation
  東京
- Year and Date
  2011-01-20
- Data Source
  KAKENHI-PROJECT-21659145
[Presentation] Significance of intestinal metabolism for various substrate drugs of CYP3A42011
- Author(s)
  Hisaka A, Tsukihashi A, Suzuki H
- Organizer
  International Symposium on BA/BE of Oral Drugs Products
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] Discrimination of hepatic and intestinal contributions to drug-drug interaction mediated by inhibition of CYP3A42011
- Author(s)
  Koh, S, Hisaka A,, Mori A, Suzuki H
- Organizer
  26th JSSX meeting
- Place of Presentation
  Hiroshima, Japan
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] Selective Degradation of CYP3A4 in Human Liver Microsome2011
- Author(s)
  Sasaki Y, Hisaka A, Suzuki H
- Organizer
  4th AP-ISSX
- Place of Presentation
  Tainan, Taiwan
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 薬物間相互作用はどこまで予測できるか(特別講演)2011
- Author(s)
  樋坂章博
- Organizer
  第16回長崎クリニカルファーマシー研究会
- Place of Presentation
  長崎
- Year and Date
  2011-03-19
- Data Source
  KAKENHI-PROJECT-21659145
[Presentation] 経口クリアランスの人種差の有意性:遺伝子変異と試験間変動の寄与2011
- Author(s)
  松波梨花, 樋坂章博, その他
- Organizer
  第4回日本ファーマコメトリクス研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 個人間変動と人種差をどのように定量化すべきか2011
- Author(s)
  樋坂章博
- Organizer
  東京大学薬学部医薬品評価科学第10回IC「薬物動態・薬効予測とレギュラトリーサイエンス」
- Place of Presentation
  東京(講演)(招待講演)
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 経口クリアランスの人種差の臨床的意義:代謝消失経路による解析2011
- Author(s)
  松波梨花, 樋坂章博, 大津洋, 鈴木洋史
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Calculation of Unambiguous Intestinal Availability from Drug-drug Interaction2011
- Author(s)
  Hisaka A, Tsukihashi A, Suzuki H
- Organizer
  4th APISSX
- Place of Presentation
  Tainan, Taiwan
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] Prediction of Clearance Changes of Drugs that are Substrates of Major Cytochrome P450 Enzymes Caused by Drug-Drug Interaction or Single Nucleotide Polymorphism2011
- Author(s)
  Hisaka A, Ohno Y, Yamaguchi R, Ueno M, Ito K, Suzuki H
- Organizer
  17th North American ISSX Meeting
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] True and false in significant ethnic differences ; how should we evaluate them in Asian drug development (Symposium)2011
- Author(s)
  Hisaka A
- Organizer
  26th JSSX meeting
- Place of Presentation
  Hiroshima(招待講演)
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 薬物間相互作用予測におけるPISCSの活用2011
- Author(s)
  樋坂章博
- Organizer
  CBI学会第322回研究講演会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-12-05
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] PISCS (pharmacokinetic interaction significance classification system) : to ward seamless drug-interaction alert (symposium)2010
- Author(s)
  Hisaka A
- Organizer
  Pharmaceutical sciences world_ congress (PSWC 2010)
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] Nappによるモデリンクとシミュレーションの紹介(シンポジスト)2010
- Author(s)
  樋坂章博
- Organizer
  第3回日本ファーマコメトリクス研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] Development of Population Model for Expression of Cytochrome P450s and Relating Enzymes in Human Liver Microsome2010
- Author(s)
  Sasaki Y, Hisaka A, Suzuki H
- Organizer
  18th International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PROJECT-21659145
[Presentation] Expressions of Hepatic Cytochrome P450 May be Regulated Dynamically and Cooperatively2010
- Author(s)
  Hisaka A, Sasaki Y, Suzuki H
- Organizer
  9th International Meeting of ISSX (2010)
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] ヒトチトクロムP450酵素発現量のLC-MS/MSによる一斉定量分析と薬物代謝活性との関係2009
- Author(s)
  佐々木優, 樋坂章博, 鈴木洋史
- Organizer
  第17回クリニカルファーマシーシンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21659145
[Presentation] 薬物間相互作用の網羅的予測とマネージメント(招待講演)2009
- Author(s)
  樋坂章博, 大野能之, 鈴木洋史
- Organizer
  第30回日本臨床薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21659145
[Presentation] ヒト肝ミクロソーム中のチトクロムP450とNADPHチトクロムP450還元酵素のLC-MS/MSによる発現量一斉解析2009
- Author(s)
  佐々木優, 樋坂章博, 鈴木洋史
- Organizer
  第24回日本薬物動態学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21659145
[Presentation] Systematic prediction of drug-drug interactions mediated by CYP3A4 from in vivo pharmacokinetics ; considerations on intestinal metabolism and transport2007
- Author(s)
  Hisaka A, Ohno Y, Suzuki H.
- Organizer
  4th World Conference on Drug Absorption, Transport and Delivery(WCDATD)
- Place of Presentation
  Tokyo, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590135
[Presentation] Pharmacokinetic analysis with transfer function model2007
- Author(s)
  Hisaka A, Suzuki H
- Organizer
  8th International Society for the Study of Xenobiotics (ISSX) Meeting
- Place of Presentation
  Sendai, Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590135
[Presentation] Pharmacokinetic Analysis with Transfer Function Model2007
- Author(s)
  Hisaka A, Suzuki H.
- Organizer
  8th International Society for the Study of Xenobiotics(ISSX)meeting
- Place of Presentation
  Sendai, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590135
[Presentation] Systematic prediction of drug-drug interactions mediated by CYP3A4 from in vivo pharmacokinetics ; considerations on intestinal metabolism and transport2007
- Author(s)
  Hisaka A, Ohno Y, Suzuki H
- Organizer
  4th World Conference on Drug Absorption,Transport and Delivery (WCDATD)
- Place of Presentation
  Tokyo, Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590135
[Presentation] Systematic Assessment of Intestinal Metabolism and Degree of Inhibition in Drug-drug Interactions Caused by Inhibition of CYP3A4.
- Author(s)
  Nakamura M, Koh S, Hisaka A, Suzuki H
- Organizer
  Annual Meeting of American Society of Clinical Pharmacology and Therapeutics
- Place of Presentation
  New Orleans, USA
- Year and Date
  2015-03-03 – 2015-03-07
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 薬物相互作用予測のための静的モデルと動的モデルの活用
- Author(s)
  樋坂章博
- Organizer
  第35回日本臨床薬理学会学術総会
- Place of Presentation
  松山
- Year and Date
  2014-12-04 – 2014-12-06
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 薬物吸収時の小腸の代謝及び輸送の定量的解析
- Author(s)
  樋坂章博
- Organizer
  第5回　杉山特別研究室（理研）公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2015-02-09 – 2015-02-10
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Estimation of Pediatric Dosages Considering Rapid Development of Physiological Functions after Birth by Approximated Simple Formulae: Implementation and Comparison with Dosages Described in the Labeling
- Author(s)
  Hisaka A, Mayuzumi T, Koshimichi T, Suzuki H
- Organizer
  19th North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25670070

1. SUZUKI Hiroshi (80206523)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
2. Sato Hiromi (30506887)

# of Collaborated Projects: 4 results

# of Collaborated Products: 32 results
3. ITO Kousei (30323405)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. KANDA Yoshinobu (30334379)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YOSHIDA Haruhiko (60240305)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HONMA Masashi (60401072)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MIURA Shougo (90529182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MIYAGAWA Kiyoshi (40200133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YAMAMOTO Takehito (00376469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. IKEBUCHI Yuki (20645725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KUSUHARA Hiroyuki (00302612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MAEDA Kazuya (00345258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKADA Tappei (90376468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUGAWARA Yasuhiko (90313155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Yamaura Katsunori (10543069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 畠山浩人 (70504786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. OISHI nobuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

HISAKA Akihiro 樋坂 章博

樋口 章博 ヒサカ アキヒロ

Research Projects

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Co-Researchers

Significance of ketone body metabolic shift in diabetes and long-term prognosis prediction

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Model based meta-analysis and establishment of PBPK model for appropriate use of factor Xa inhibitor

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Expression of precipitating factors of pruritus found in humans in an imiquimodinduced psoriasis mouse model

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Epigenetic regulation shifted cellular metabolism of cancer cells, which contributed to potentiate drug sensitivity of antiangiogenic agents.

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Development of Micro-blood-sampling Method for Pharmacokinetic Analysis in Clinical StudiesPrincipal Investigator

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Comprehensive analysis of the factors regulating the disposition of small molecules at organ and tissue levels

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Research on Drug-Induced Liver Injury Associated with MetabolicActivation by CYPPrincipal Investigator

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Physiological situation based prediction of the adverse effects associated with molecularly-targeted drugs.

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抗血小板薬の標的酵素あるいは受容体の修飾を検出するバイオマーカーによる薬効評価Principal Investigator

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Establishment of quantitative prediction method for the individual variabilities in hematologic toxicity of anti-cancer agents

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Systematic analysis of intestinal absorption process considering drug transportation across membranesPrincipal Investigator

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[Book] 代謝酵素,トランスポーターによる薬物間相互作用,個人間変動が薬効、副作用に与える影響の解析:創薬科学の魅力-東京大学大学院薬学系研究科からの発信2010

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[Book] Principles of pharmacokinetics : Predicting human pharmacokinetics in drug discovery. in "Mass Spectrometry in Drug Metabolism and Disposition : Basic Principles and Applications"2010

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HISAKA Akihiro 樋坂章博

樋口章博ヒサカアキヒロ