Bessho Kazuhiko 別所一彦

… Alternative Names

別所一彦ベツシヨカズヒコ

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Researcher Number	80423169
Other IDs
Affiliation (Current)	2025: 滋慶医療科学大学, 医療管理学研究科, 教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 大阪大学, 医学系研究科, 准教授 2016 – 2018: 大阪大学, 医学系研究科, 講師 2017: 大阪大学, 医学(系)研究科(研究院), 助教 2017: 大阪大学, 医学(系)研究科(研究院), 講師 2015: 大阪大学, 医学(系)研究科(研究院), 講師 … More 2014: 大阪大学, 医学(系)研究科(研究院), 助教 2010: Osaka University, 医学(系)研究科(研究院), 助教 2009: Osaka University, 医学系研究科, 助教 2008: Osaka University, 大学院・歯学研究科, 助教 Less
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Pediatrics
Keywords	Principal Investigator 胆道閉鎖症 / 胆汁うっ滞 / エピジェネティクス / ゲノム解析 / 双胎 / コピー数多型解析 / 一塩基多型 / コピー数解析 / 全エクソーム解析 / エクソーム解析 … More / 一卵性双生児 / 国際情報交換 / 腸内細菌叢 / 肝細胞増殖因子 / 肝再生 / パラビオーシス / 胆管結紮 / 核内受容体 / 胆汁酸トランスポーター … More Except Principal Investigator 胆汁鬱滞 / KLB / FGFR4 / 胆道閉鎖症 / microdisection / HNF4α / SPRY2 / 胆汁酸合成 / FGF19 / CYP7A1 / 胆汁うっ滞 Less

Genetic predisposition to biliary atresia by comprehensive genomic analyses on monozygotic twins with unilateral onsetPrincipal Investigator
- Principal Investigator
  
  Bessho Kazuhiko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka University
Investigation of aberrant regulation of bile acid, glucose, and lipid metabolism under chronic cholestatic state in pediatric liver disease.
- Principal Investigator
  
  KONDOU Hiroki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kindai University
  Osaka University
The role of intestinal flora in the pathogenesis of biliary atresiaPrincipal Investigator
- Principal Investigator
  
  Bessho Kazuhiko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
胆汁うっ滞肝における胆汁酸トランスポーターの発現解析と肝細胞増殖因子による制御Principal Investigator
- Principal Investigator
  
  別所一彦
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University

All 2021 2019 2018 2017 2016 2015 2014 2009 2008 Other

All Journal Article Presentation Book

[Book] Introduction to Biliary Atresia2021
- Author(s)
  Bessho K, Satomura Y
- Total Pages
  361
- Publisher
  SpringerLink
- ISBN
  9789811621598
- Data Source
  KAKENHI-PROJECT-18K07844
[Journal Article] Total bile acid concentration in duodenal fluid is a useful preoperative screening marker to rule out biliary atresia.2018
- Author(s)
  Fukuoka T, Bessho K, Tachibana M, Satomura Y, Konishi A, Yasuda K, Kimura T, Hasegawa Y, Ueno T, Miyoshi Y, Ozono K
- Journal Title
  
  Journal of pediatric gastroenterology and nutrition
  
  Volume: 67 Issue: 3 Pages: 383-387
- DOI
  10.1097/mpg.0000000000002037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07844
[Journal Article] Total Bile Acid Concentration in duodemal fluid Is a Useful Preoperative Screening Marker to Rule Out Biliary Atresia2018
- Author(s)
  Tomoya Fukuoka, Kazuhiko Bessho, Makiko Tachibana, Yoshinori Satomura, Akiko Konishi, Kie Yasuda, Takeshi Kimura, Yasuhiro Hasegawa, Takehisa Ueno, Yoko Miyoshi, and Keiichi Ozono
- Journal Title
  
  Journal of Pediatric Gastroenterology and Nutrition
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461609
[Journal Article] Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates.2017
- Author(s)
  Carey AN, Zhang W, Setchell KD, Simmons JE, Shi T, Lages CS, Mullen M, Carroll K, Karns R, Bessho K, Sheridan R, Zhao X, Weber SN, Miethke AG
- Journal Title
  
  Pediatr Res.
  
  Volume: 印刷中 Issue: 1 Pages: 122-132
- DOI
  10.1038/pr.2017.78
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461609
[Journal Article] Circulating tricarboxylic acid cycle metabolite levels in citrin-deficient children with metabolic adaptation, with and without sodium pyruvate treatment.2017
- Author(s)
  Nagasaka H, Komatsu H, Inui A, Nakacho M, Morioka I, Tsukahara H, Kaji S, Hirayama S, Miida T, Kondou H, Ihara H, Yagi M, Kizaki Z, Bessho K, Kodama T, Iijima K, Saheki T, Yorifuji T, Honda A
- Journal Title
  
  Mol. Genet. Metab.
  
  Volume: 120 Issue: 3 Pages: 207-212
- DOI
  10.1016/j.ymgme.2016.12.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K00849, KAKENHI-PROJECT-15K09595, KAKENHI-PROJECT-26461609, KAKENHI-PROJECT-15K08624, KAKENHI-PROJECT-26461644
[Journal Article] Impact of Donor-Specific Antibodies on Graft Fibrosis After Pediatric Living Donor Liver Transplantation for Biliary Atresia.2016
- Author(s)
  Ueno T, Zenitani M, Yamanaka H, Tanaka N, Uehara S, Tazuke Y, Bessho K, Okuyama H.
- Journal Title
  
  Transplant Proc.
  
  Volume: 48 Issue: 4 Pages: 1095-1099
- DOI
  10.1016/j.transproceed.2016.02.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461609
[Journal Article] Disseminated Metastatic Tissue Calcification After Orthotopic Liver Transplantation: A Case Report2016
- Author(s)
  Deguchi K, Ueno T, Matsuura R, Yamanaka H, Nara K, Uehara S, Tazuke Y, Bessho K, Okuyama H.
- Journal Title
  
  Transplant Proc
  
  Volume: 48 Issue: 1 Pages: 251-254
- DOI
  10.1016/j.transproceed.2015.12.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461609
[Journal Article] Reply: To PMID 244932872015
- Author(s)
  Mourya R, Bessho K, Shivakumar P, Bezerra JA
- Journal Title
  
  Hepatology
  
  Volume: 61 Issue: 2 Pages: 732-3
- DOI
  10.1002/hep.27231
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461609
[Journal Article] Natural killer cells promote long-term hepatobiliary inflammation in a low-dose rotavirus model of experimental biliary atresia.2015
- Author(s)
  Squires JE, Shivakumar P, Mourya R, Bessho K, Walters S, Bezerra JA
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 5 Pages: 1-15
- DOI
  10.1371/journal.pone.0127191
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461609
[Journal Article] Complications and Quality of Life in Long-Term Survivors of Biliary Atresia with Their Native Livers2015
- Author(s)
  Bessho K
- Journal Title
  
  J Pediatr
  
  Volume: 167 Issue: 6 Pages: 1202-1206
- DOI
  10.1016/j.jpeds.2015.08.041
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461609
[Journal Article] Gene expression signature for biliary atresia and a role for Interleukin-8 in pathogenesis of experimental disease2014
- Author(s)
  Bessho K, Mourya R, Shivakumar P, Walters S, Magee JC, Jegga AG, Rao M and Bezerra JA
- Journal Title
  
  Hepatology
  
  Volume: 60 Issue: 1 Pages: 211-23
- DOI
  10.1002/hep.27045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461609
[Journal Article] Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism.2009
- Author(s)
  Bessho K, Etani Y, Ichimori H, Miyoshi Y, Namba N, Yoneda A, Ooue T, Chihara T, Morii E, Aoki T, Murakami M, Mushiake S, Ozono K
- Journal Title
  
  European Journal of Pediatrics 169
  
  Pages: 215-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790726
[Journal Article] Increased type 3 iodothyronine deiodinase activity in a relapsed hemangioma following treatment for diffuse infantile hepatic hemangiomas with consumptive hypothyroidism
- Author(s)
  Kazuhiko Bessho, et.al.
- Journal Title
  
  Journal of European Pediatrics (投稿中)(確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790726
[Presentation] 大阪大学医学部附属病院小児科・小児外科における胆道閉鎖症成人患者の現状と成人診療科への移行の問題点2019
- Author(s)
  里村宜紀，別所一彦，大沼真輔，和田珠希，福岡智哉，安田紀恵，木村武司，橘真紀子，三善陽子，上野豪久，大薗恵一
- Organizer
  第21回　大阪肝移植研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07844
[Presentation] 超音波検査にて胆嚢の萎縮を認めず診断の遅れた胆道閉鎖症の2例2018
- Author(s)
  福岡智哉，別所一彦，大沼真輔，和田珠希，里村宜紀，安田紀恵，木村武司，橘真紀子，上野豪久，三善陽子，大薗恵一
- Organizer
  第45回　胆道閉鎖症研究会
- Data Source
  KAKENHI-PROJECT-18K07844
[Presentation] Biliary Atresia, how to improve the outcomes.2018
- Author(s)
  Bessho K
- Organizer
  Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07844
[Presentation] 胆道閉鎖症の診断における十二指腸液採取と肝胆道シンチグラフィの有用性に対する検討2017
- Author(s)
  福岡智哉，橘真紀子，里村宜紀，安田紀恵，長谷川泰浩，別所一彦，三善陽子，大薗恵一
- Organizer
  第30回近畿小児科学会
- Place of Presentation
  大阪
- Year and Date
  2017-03-12
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] 現在の移植医療の問題点2017
- Author(s)
  別所一彦
- Organizer
  第9回日本小児栄養消化器肝臓学会卒後教育セミナー
- Place of Presentation
  川崎
- Year and Date
  2017-01-14
- Invited
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] The role of immune response and gene variations in the etiology of biliary atresia.2017
- Author(s)
  Bessho K
- Organizer
  The 54 Annual Congress of the Japanese Society of Pediatric Surgery and the 7th International Sendai Symposium on Biliary Atresia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] 胆道閉鎖症の遺伝的素因について2017
- Author(s)
  別所一彦
- Organizer
  BA brain storming
- Place of Presentation
  東京
- Year and Date
  2017-01-09
- Invited
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] 大阪大学医学部附属病院における小児肝移植適応決定のプロセス2016
- Author(s)
  別所一彦
- Organizer
  第3回小児がん拠点病院放射線技師研修会
- Place of Presentation
  大阪
- Year and Date
  2016-02-27
- Invited
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] 胆道閉鎖症の診断における十二指腸液採取と肝胆道シンチグラフィの有用性に対する検討2016
- Author(s)
  福岡智哉，橘真紀子，里村宜紀，小西暁子，安田紀恵，木村武司，倉川佳世、長谷川泰浩，別所一彦，三善陽子，大薗恵一
- Organizer
  第43回日本小児栄養消化器肝臓学会
- Place of Presentation
  つくば
- Year and Date
  2016-09-16
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] Dissociation Between Clinical Evaluation and PELD Score in The Setting of Pediatric Living-Related Liver Transplantation in JAPAN: A 18 Year Single Center Experience.2016
- Author(s)
  Bessho K, Hasegawa Y, Fukuda H, Hagiwara K, Ueno T, Miyoshi Y, Kondou H, Mushiake S, Okuyama H, Ozono K.
- Organizer
  The International Liver Congress 2016
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] 肝組織像からPFIC3が疑われ、遺伝子検査にて診断確定した2歳男児の1例.2016
- Author(s)
  里村宜紀，小西暁子，安田紀恵，長谷川泰浩，別所一彦，三善陽子，大薗恵一
- Organizer
  第33回日本小児肝臓研究会
- Place of Presentation
  岐阜
- Year and Date
  2016-07-02
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] 生体肝移植・これからの課題肝移植後のグラフト線維化と小児生体肝移植後抗ドナー抗体の影響　胆道閉鎖症に対する生体肝移植後の検討2016
- Author(s)
  上野豪久, 田中夏美, 銭谷昌弘, 山中宏晃, 高間勇一, 田附裕子, 別所一彦, 奥山宏臣
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] 胆道閉鎖症患者の肝臓では胆汁酸生合成律速酵素CYP7A1の抑制機構の破綻が起きている2015
- Author(s)
  長谷川泰浩, 近藤宏樹, 別所一彦, 川井正信, 安田紀恵, 上野豪久, 里村宜紀, 小西暁子, 木村武司, 倉川佳世, 三善陽子, 道上敏美, 大薗恵一
- Organizer
  第42回日本小児栄養消化器肝臓学会
- Place of Presentation
  広島
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] 胆道閉鎖症患者の肝臓では胆汁酸生合成律速酸素CYP7A1の抑制機構の破綻が起きている2015
- Author(s)
  長谷川泰浩, 近藤宏樹, 別所一彦, 川井正信, 安田紀恵, 上野豪久, 里村宜紀, 小西暁子, 木村武司, 倉川佳世, 三善陽子, 道上敏美, 大薗恵一
- Organizer
  第32回日本小児肝臓研究会
- Place of Presentation
  鳥取
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] Phenotyping of patients with biliary atresia towards personalized therapy2015
- Author(s)
  Bessho K
- Organizer
  The second joint meeting of Japan-Taiwan-Korean Pediatric Societies of Pediatric Gastroenterology, Hepatology and Nutrition
- Place of Presentation
  東京
- Year and Date
  2015-11-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] 胆道閉鎖症の動物モデル　–その有用性と限界点-2015
- Author(s)
  別所一彦
- Organizer
  第42回日本小児栄養消化器肝臓学会
- Place of Presentation
  広島
- Year and Date
  2015-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] A case of chronic rejection after liver transplantation for acute liver failure2015
- Author(s)
  Zenitani S, Bessho K, Kondou H, Hasegawa Y, Yasuda K, Konishi A, Satomura Y, Miyoshi Y, Ueno T, Ozono K
- Organizer
  11th Asian Society for Pediatric Research
- Place of Presentation
  大阪
- Year and Date
  2015-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] Gene Expression Signature for Biliary Atresia and a Role for IL-8 in the Pathogenesis of Experimental Disease2015
- Author(s)
  別所一彦
- Organizer
  第32回小児肝臓研究会
- Place of Presentation
  鳥取大学
- Year and Date
  2015-07-25
- Invited
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] Gene Expression Signature for Biliary Atresia and a Role for IL-8 in the Pathogenesis of Experimental Disease.2014
- Author(s)
  Bessho K, Mourya R, Shivakumar P, Walters S, Magee JC, Jegga AG, Rao M and Bezerra JA
- Organizer
  BARD-Berlin
- Place of Presentation
  Berlin, Germany
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] Introduction, Recent progress in biliary atresia in the world.2014
- Author(s)
  Bessho K
- Organizer
  2014 PAS/ASPR Joint Meeting
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2014-05-04
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] Dysregulation of Cholesterol 7 alpha-hydroxylase (CYP7A1) is involved in the abnormal bile acid synthesis in livers from biliary atresia (BA) children2014
- Author(s)
  Hasegawa Y, Kondou H, Bessho K, Kawai M, Nakao K, Ueno T, Satomura Y, Konishi A, Kimura T, Ikeda K, Tachibana M, Miyoshi Y, Michigami T, Ozono K
- Organizer
  The Liver Meeting 2014
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2014-11-10
- Data Source
  KAKENHI-PROJECT-26461609
[Presentation] Alagille症候群における高コレステロール血症に関する検討2009
- Author(s)
  清原由起、別所一彦、村上真理、橘真紀子長谷川泰浩、山田寛之、三善陽子、虫明聡太郎
- Organizer
  日本小児肝臓研究会
- Place of Presentation
  中野サンプラザ
- Year and Date
  2009-07-20
- Data Source
  KAKENHI-PROJECT-20790726
[Presentation] Three Pediatric Patients with Fever-induced Recurrent Severe Hypertra nsaminasemia and Coagulopathv with Transient Hepatic Steatosis2008
- Author(s)
  Kazuhiko Bessho, et.al.
- Organizer
  World Congress of Pediatric Gastroenterology, Hepatology and Nutrition
- Place of Presentation
  Iguassu Falls, Brazil
- Year and Date
  2008-08-19
- Data Source
  KAKENHI-PROJECT-20790726

1. KONDOU Hiroki (10373515)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. HONDA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Bessho Kazuhiko 別所 一彦

別所 一彦 ベツシヨ カズヒコ

Research Projects

Research Products

Co-Researchers

Genetic predisposition to biliary atresia by comprehensive genomic analyses on monozygotic twins with unilateral onsetPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of aberrant regulation of bile acid, glucose, and lipid metabolism under chronic cholestatic state in pediatric liver disease.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of intestinal flora in the pathogenesis of biliary atresiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胆汁うっ滞肝における胆汁酸トランスポーターの発現解析と肝細胞増殖因子による制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Introduction to Biliary Atresia2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Total bile acid concentration in duodenal fluid is a useful preoperative screening marker to rule out biliary atresia.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Total Bile Acid Concentration in duodemal fluid Is a Useful Preoperative Screening Marker to Rule Out Biliary Atresia2018

Author(s)

Journal Title

Data Source

[Journal Article] Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating tricarboxylic acid cycle metabolite levels in citrin-deficient children with metabolic adaptation, with and without sodium pyruvate treatment.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of Donor-Specific Antibodies on Graft Fibrosis After Pediatric Living Donor Liver Transplantation for Biliary Atresia.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disseminated Metastatic Tissue Calcification After Orthotopic Liver Transplantation: A Case Report2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reply: To PMID 244932872015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Natural killer cells promote long-term hepatobiliary inflammation in a low-dose rotavirus model of experimental biliary atresia.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Complications and Quality of Life in Long-Term Survivors of Biliary Atresia with Their Native Livers2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene expression signature for biliary atresia and a role for Interleukin-8 in pathogenesis of experimental disease2014

Bessho Kazuhiko 別所一彦

別所一彦ベツシヨカズヒコ