SHIMA Haruko 嶋晴子

Researcher Number	80424167
Affiliation (based on the past Project Information) *help	2016 – 2017: 慶應義塾大学, 医学部(信濃町), 助教 2009 – 2015: Keio University, 医学部, 助教 2011 – 2012: 独立行政法人国立がん研究センター, 研究所, 特任研究員
Review Section/Research Field	Principal Investigator Pediatrics Except Principal Investigator Pediatrics
Keywords	Principal Investigator 白血病幹細胞 / チロシンキナーゼ阻害薬 / CML / 小児CML / チロシンキナーゼ阻害剤 / フローサイトメトリー / 小児慢性骨髄性白血病 / Glis2 / MOZ-TIF2 / 低酸素 … More / 細胞周期 / NOGマウス / M-CSFR / 急性骨髄性白血病 / 白血病 / ニッチ / 造血幹細胞 … More Except Principal Investigator トランスクリプトーム解析 / エピゲノム解析 / IKZF1遺伝 / 慢性骨髄性白血 / ゲノム解析 / IKZF1遺伝子 / フィラデルフィア染色体陽性急性リンパ性白血病 / 慢性骨髄性白血病 / 白血病 / リン酸化 / プロテオーム / 生体分子 / 癌 / 小児腫瘍学 Less

Flow cytometric analysis to predict prognosis in children with chronic-phase CML treated with imatinibPrincipal Investigator
- Principal Investigator
  
  Shima Haruko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University
Genome- and gene expression-based drug discovery for pediatric Philadelphia chromosome positive leukemia
- Principal Investigator
  
  SHIMADA HIROYUKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University
Regulation of leukemia stem cells in MOZ-TIF2 AMLPrincipal Investigator
- Principal Investigator
  
  SHIMA Haruko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  National Cancer Center Japan
Proteomic analysis of phosphorylation in leukemic cells
- Principal Investigator
  
  SHIMADA Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University
Leukemic stem cell in humanized mouse bone marrow nichePrincipal Investigator
- Principal Investigator
  
  SHIMA Haruko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University

All 2017 2015 2014 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Flow cytometric analysis as an additional predictive tool of treatment response in children with chronic-phase chronic myeloid leukemia treated with imatinib2017
- Author(s)
  Shima Haruko、Kiyokawa Nobutaka、Miharu Masashi、Tanizawa Akihiko、Kurosawa Hidemitsu、Watanabe Akihiro、Ito Masaki、Tono Chikako、Yuza Yuki、Muramatsu Hideki、Hotta Noriko、Okada Masahiko、Hamamoto Kazuko、Kajiwara Ryosuke、Saito Akiko M、Horibe Keizo、Mizutani Shuki、Adachi Souichi、Ishii Eiichi、Shimada Hiroyuki
- Journal Title
  
  Pediatric Blood & Cancer
  
  Volume: 64 Issue: 9
- DOI
  10.1002/pbc.26478
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461594
[Journal Article] Flow cytometric analysis as an additional predictive tool of treatment response in children with chronic-phase chronic myeloid leukemia treated with imatinib.2017
- Author(s)
  Shima H, Kiyokawa N, Miharu M, Tanizawa A, Kurosawa H, Watanabe A, Ito M, Tono C, Yuza Y, Muramatsu H, Hotta N, Okada M, Hamamoto K, Kajiwara R, Saito AM, Horibe K, Mizutani S, Adachi S, Ishii E, Shimada H.
- Journal Title
  
  Pediatr Blood and Cancer.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461594
[Journal Article] 骨髄系腫瘍の幹細胞とその標的分子2012
- Author(s)
  嶋晴子,北林一生
- Journal Title
  
  血液フロンティア
  
  Volume: 22巻 Pages: 53-60
- Data Source
  KAKENHI-PROJECT-23791206
[Journal Article] 骨髄系腫瘍の幹細胞とその標的分子2012
- Author(s)
  嶋晴子、北林一生
- Journal Title
  
  血液フロンティア
  
  Volume: Vol. 22 Pages: 53-60
- Data Source
  KAKENHI-PROJECT-23791206
[Journal Article] MOZ-TIF2白血病における白血病幹細胞の生成機構2011
- Author(s)
  嶋晴子、北林一生
- Journal Title
  
  血液内科 62巻、1号
  
  Pages: 409-414
- NAID
  40019064537
- Data Source
  KAKENHI-PROJECT-21791008
[Journal Article] 幹細胞生物学からみたAML治療の新たな方向性2011
- Author(s)
  嶋晴子、北林一生
- Journal Title
  
  血液内科 62巻、4号
  
  Pages: 98-105
- Data Source
  KAKENHI-PROJECT-21791008
[Journal Article] MOZ-TIF2白血病における白血病幹細胞の生成機構2011
- Author(s)
  嶋晴子, 北林一生
- Journal Title
  
  血液内科
  
  Volume: 62 Pages: 98-105
- NAID
  40019064537
- Data Source
  KAKENHI-PROJECT-21791008
[Journal Article] PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.2010
- Author(s)
  Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I.
- Journal Title
  
  Nature Medicine. Vol.16、No.5
  
  Pages: 580-585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791008
[Journal Article] Acquisition of G(0) state by CD34-positive cord blood cells after bone marrow transplantation.2010
- Author(s)
  Shima H, Takubo K, Tago N, Iwasaki H, Arai F, Takahashi T, Suda T.
- Journal Title
  
  Experimental Hematology. Vol.38、No.12
  
  Pages: 1231-1240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791008
[Journal Article] Acquisition of G_0 state by CD34-positive cord blood cells after bonemarrow transplantation.2010
- Author(s)
  Shima H, Takubo K, Tago N, Iwasaki H, Arai F, Takahashi T,Suda T.
- Journal Title
  
  Experimental Hematology
  
  Volume: 38 Pages: 1231-1240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791008
[Presentation] Interim Analysis of a Multicenter, Prospective Study for Pediatric Chronic Myeloid Leukemia in Chronic Phase: The JPLSG CML-08 Study2015
- Author(s)
  Hiroyuki Shimada
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  オーランド（アメリカ）
- Year and Date
  2015-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461608
[Presentation] 小児フィラデルフィア染色体陽性急性リンパ性白血病（Ph+ALL）におけるIKZF1遺伝子欠失と予後との関連2014
- Author(s)
  嶋田博之、佐藤　篤、河崎裕英、松本公一、加藤　格、児玉祐一、加藤啓輔、工藤寿子、齋藤明子、足立壮一、堀部敬三、水谷修紀、真部淳
- Organizer
  日本造血細胞移植学会総会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-25461608
[Presentation] Roles of Ring1A/B in Stem Cell Potential of MOZ and Other Acute Myeloid Leukemias2012
- Author(s)
  Haruko Shima, Mika Shino, Kazutsune Yamagata, Yukiko Aikawa, Haruhiko Koseki, Issay Kitabayashi
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-23791206
[Presentation] ROLES OF RING1A/B IN STEM CELL POTENTIAL OF MOZ AND OTHER ACUTE MYELOID LEUKEMIAS2012
- Author(s)
  Haruko Shima, Mika Shino, Kazutsune Yamagata, Yukiko Aikawa, Haruhiko Koseki, Issay Kitabayashi.
- Organizer
  International Society for Stem Cell Research 10th Annual Meeting
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23791206
[Presentation] Roles of Ring1A/B in stem cell potential of MOZ and other acute myeloid leukemias2012
- Author(s)
  Haruko Shima, Mika Shino, Kazutsune Yamagata, Yukiko Aikawa, Haruhiko Koseki, Issay Kitabayashi
- Organizer
  International Society for Stem Cell Research 10th Annual Meeting
- Place of Presentation
  横浜
- Year and Date
  2012-06-16
- Data Source
  KAKENHI-PROJECT-23791206
[Presentation] Roles of Ring1A/B on Stem Cell Potential of MOZ and Other Acute Myeloid Leukemias2011
- Author(s)
  Haruko Shima, Mika Shino, Kazutsune Yamagata, Yukiko Aikawa, Haruhiko Koseki, Issay Kitabayashi
- Organizer
  53rd ASH Annual Meeting and Exposition
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-23791206
[Presentation] Essential role of BRPF1/HOX pathway in MOZ-TIF2-induced acute myeloid leukemia2011
- Author(s)
  Haruko Shima, Kazutsune Yamagata, Yukiko Aikawa, Mika Shino, Haruhiko Koseki, Issay Kitabayashi
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-23791206
[Presentation] Phosphoproteomic profiling of leukemia cells2010
- Author(s)
  Yoshihara H, Shimada H, Shima H, Tomita M, Ishihama Y
- Organizer
  15th European Hematology Association congress
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-22591168
[Presentation] Regulation of stem cells in MOZ and other leukemias2010
- Author(s)
  Haruko Shima, Yukiko Aikawa, Kumiko Yamanaka, Takuo Katsumoto, Mika Shino, Akihiko Koseki, Issay Kitabayashi
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21791008
[Presentation] Regulation of stem cells in MOZ and other leukemias2010
- Author(s)
  Haruko Shima
- Organizer
  幹細胞シンポジウム
- Place of Presentation
  淡路(兵庫県)
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21791008
[Presentation] Acquisition of GO state in CD34-positive cord blood cells after bone marrow transplantation2009
- Author(s)
  嶋晴子
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21791008
[Presentation] Acquisition of G0 state in CD34-positive cord blood cells after bone marrow transplantation.2009
- Author(s)
  Haruko Shima, Keiyo Takubo, Naoko Tago, Hiroko Iwasaki, Kentaro Hosokawa, Hiroki Yoshihara, Fumio Arai, Takao Takahashi, Issay Kitabayashi, Toshio Suda.
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21791008
[Presentation] A multicenter, prospective observational study for pediatric CML in CP (JPLSG CML-08):Preliminary analysis 2014
- Author(s)
  Hiroyuki Shimada, Hidemitsu Kurosawa, Akihiro Watanabe, Masaki Ito, Chikako Tono, Haruko Shima, Yuki Yuza, Hideki Muramatsu, Noriko Hotta, Masahiko Okada, Akihiko Tanizawa
- Organizer
  日本小児血液・がん学会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2014-11-28 – 2014-11-30
- Data Source
  KAKENHI-PROJECT-25461608
[Presentation] Flow cytometric analysis as predicting treatment response in pediatric CML-chronic phase (JPLSG CML-08)
- Author(s)
  Haruko Shima, Nobutaka Kiyokawa, Akihiko Tanizawa, Hidemitsu Kurosawa, Akihiro Watanabe, Masaki Ito, Chikako Tono, Yuki Yuza, Hideki Muramatsu, Noriko Hotta, Masahiko Okada, Hiroyuki Shimada
- Organizer
  第56回日本小児血液・がん学会学術集会
- Place of Presentation
  岡山コンベンションセンター（岡山県岡山市）
- Year and Date
  2014-11-28 – 2014-11-30
- Data Source
  KAKENHI-PROJECT-26461594

1. SHIMADA Hiroyuki (80265868)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. KIYOKAWA NOBUTAKA (60195401)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. YOSHIHARA Hiroki (90348706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. ISHIHAMA Yasushi (30439244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. KITABAYASHI Kazuo (20261175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIMA Haruko 嶋 晴子

Research Projects

Research Products

Co-Researchers

Flow cytometric analysis to predict prognosis in children with chronic-phase CML treated with imatinibPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genome- and gene expression-based drug discovery for pediatric Philadelphia chromosome positive leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of leukemia stem cells in MOZ-TIF2 AMLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteomic analysis of phosphorylation in leukemic cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Leukemic stem cell in humanized mouse bone marrow nichePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Flow cytometric analysis as an additional predictive tool of treatment response in children with chronic-phase chronic myeloid leukemia treated with imatinib2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Flow cytometric analysis as an additional predictive tool of treatment response in children with chronic-phase chronic myeloid leukemia treated with imatinib.2017

Author(s)

Journal Title

Data Source

[Journal Article] 骨髄系腫瘍の幹細胞とその標的分子2012

Author(s)

Journal Title

Data Source

[Journal Article] 骨髄系腫瘍の幹細胞とその標的分子2012

Author(s)

Journal Title

Data Source

[Journal Article] MOZ-TIF2白血病における白血病幹細胞の生成機構2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 幹細胞生物学からみたAML治療の新たな方向性2011

Author(s)

Journal Title

Data Source

[Journal Article] MOZ-TIF2白血病における白血病幹細胞の生成機構2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.2010

Author(s)

Journal Title

Data Source

[Journal Article] Acquisition of G(0) state by CD34-positive cord blood cells after bone marrow transplantation.2010

Author(s)

Journal Title

Data Source

[Journal Article] Acquisition of G_0 state by CD34-positive cord blood cells after bonemarrow transplantation.2010

Author(s)

Journal Title

Data Source

[Presentation] Interim Analysis of a Multicenter, Prospective Study for Pediatric Chronic Myeloid Leukemia in Chronic Phase: The JPLSG CML-08 Study2015

Author(s)

Organizer

SHIMA Haruko 嶋晴子