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Ohkawa Kazuyoshi  大川 和良

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OHKAWA Kazuyoshi  大川 和良

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Researcher Number 80432540
Affiliation (Current) 2025: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 肝胆膵内科 主任部長
Affiliation (based on the past Project Information) *help 2010: Osaka University, 肝胆膵内科, 副部長
2009: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses, 肝胆膵内科, 副部長
2007 – 2008: Osaka University, Graduate School of Medicine, Assistant professor
2006: 大阪大学, 医学系研究科, 寄附講座助手
Review Section/Research Field
Principal Investigator
Gastroenterology
Except Principal Investigator
Gastroenterology
Keywords
Principal Investigator
Relaxed-circular (RC) HBV DNA / HBV mutation / Hepatitis B virus (HBV) / 環状2本鎖(RC)HBV DNA / HBV変異 / B型肝炎ウイルス(HBV) / B型劇症肝疾患 / 薬剤耐性変異ウイルス / 核酸アナログ / インターフェロン-γ … More / HBV増殖活性 / 活動性B型肝炎発症 / 無症候性HBVキャリア / B型肝炎ウイルス変異 / B型肝炎ウイルス複製 / B型肝炎 / 肝臓学 … More
Except Principal Investigator
自己消化 / 代謝疾患 / 肝臓 / GFP-LC3 / 非アルコール性脂肪性肝炎 / 脂肪肝 / 酵素抗体法 / LC3 / マウス / MCD / NASH / オートファジー Less
  • Research Projects

    (3 results)
  • Research Products

    (50 results)
  • Co-Researchers

    (3 People)
  •  Mechanisms for hepatitis B virus replication and mutagenesis : investigations using virus-expressing mouse system.Principal Investigator

    • Principal Investigator
      OHKAWA Kazuyoshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  非アルコール性脂肪性肝疾患と肝硬変におけるオートファジーの解析とその意義の解明

    • Principal Investigator
      TAKEHARA Tetsuo
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Hepatitis B virus mutations affecting synthesis of relaxed-circular viral DNA : Relation to disease severityPrincipal Investigator

    • Principal Investigator
      OHKAWA Kazuyoshi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University

All 2010 2009 2008 2007 2006

All Journal Article Presentation

  • [Journal Article] Improved diagnosis of well-differentiated hepatocellular carcinoma with Gd-EOB-DTPA-enhanced MRI and Sonazoid contrast-enhanced ultrasonography.2010

    • Author(s)
      Kawada N, Ohkawa K, et al.
    • Journal Title

      Hepatol Res 40

      Pages: 930-6

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Prior splenic irradiation reduces hematologic adverse events during chemotherapy in pancreatic tail cancer : a report of a patient with liver cirrhosis.2010

    • Author(s)
      Ohkawa K, et al.
    • Journal Title

      Clin J Gasroenterol

      Volume: 3 Pages: 337-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Fatal exacerbation of type B chronic hepatitis triggered by changes in relaxed circular viral DNA synthesis and virion secretion.2010

    • Author(s)
      Ohkawa K, et al.
    • Journal Title

      Biochem Biophys Res Commun 394

      Pages: 87-93

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Alterations in hepatitis B virus nucleotide sequences in a chronic virus carrier from immunotolerant to immunoactive phase.2010

    • Author(s)
      Ohkawa K, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 394 Pages: 574-80

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Alterations in hepatitis B virus nucleotide sequences in a chronic virus carrier from immunotolerant to immunoactive phase.2010

    • Author(s)
      Ohkawa K, et al.
    • Journal Title

      Biochem Biophys Res Commun 394

      Pages: 574-80

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Prior splenic irradiation reduces hematologic adverse events during chemotherapy in pancreatic tail cancer : a report of a patient with liver cirrhosis.2010

    • Author(s)
      Ohkawa K, et al.
    • Journal Title

      Clin J Gasroenterol 3

      Pages: 337-42

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Improved diagnosis of well-differentiated hepatocellular carcinoma with Gd-EOB-DTPA-enhanced MRI and Sonazoid contrast-enhanced ultrasonography.2010

    • Author(s)
      Kawada N, Ohkawa K, et al.
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 930-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Mutations associated with the therapeutic efficacy of adefovir dipivoxiladded to lamivudine in patients with type B chronic hepatitis.2009

    • Author(s)
      Ohkawa K, et al.
    • Journal Title

      Journal of Medical Virology (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Lamivudine-to-entecavir switching treatment in type B chronic hepatitis patients without evidence of lamivudine resistance.2009

    • Author(s)
      Kurashige N, Ohkawa K, et al.
    • Journal Title

      Journal of Gastroenterology 44

      Pages: 864-70

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Factors contributing to antiviral effect of adefovir dipivoxil therapy added to ongoing lamivudine treatment in patients with lamivudine-resistant chronic hepatitis B.2009

    • Author(s)
      Kurashige N, Hiramatsu N, Ohkawa K, et al.
    • Journal Title

      Journal of Gastroenterology 44

      Pages: 601-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Two kinds of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir.2009

    • Author(s)
      Kurashige N, Ohkawa K, et al.
    • Journal Title

      Antivir Ther 14

      Pages: 873-7

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Mutations associated with the therapeutic efficacy of adefovir dipivoxil added to lamivudine in patients resistant to lamivudine with type B chronic hepatitis.2009

    • Author(s)
      Ohkawa K, et al.
    • Journal Title

      J Med Virol 81

      Pages: 798-806

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Lamivudine-to-entecavir switching treatment in type B chronic hepatitis patients without evidence of lamivudine resistance.2009

    • Author(s)
      Kurashige N, Ohkawa K, et al.
    • Journal Title

      J Gastroenterol 44

      Pages: 864-70

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Factors contributing to antiviral effect of adefovir dipivoxil therapy added to ongoing lamivudine treatment in patients with lamivudine-resistant chronic hepatitis2009

    • Author(s)
      Kurashige N, Hiramatsu N, Ohkawa K, et al.
    • Journal Title

      B.J Gastroenterol 44

      Pages: 601-7

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus.2008

    • Author(s)
      Ohkawa K, et al.
    • Journal Title

      J Infect Dis 198

      Pages: 1150-8

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine.2008

    • Author(s)
      Kurashige N, Hiramatsu N, Ohkawa K, et. al.
    • Journal Title

      Hepatology Research (in press)

    • NAID

      10024148320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine.2008

    • Author(s)
      Kurashige N, Hiramatsu N, Ohkawa K, et al.
    • Journal Title

      Hepatol Res 38

      Pages: 450-6

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Early emergence of entecavir-resistant hepatitis B virus in a patient with hepatitis B virus/human immunodeficiency virus coinfection2008

    • Author(s)
      Kanada, A, Takehara, T, Ohkawa, K, et. al.
    • Journal Title

      Hepatol Res (in press)

    • NAID

      10024149003

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus.2008

    • Author(s)
      Ohkawa K, et al.
    • Journal Title

      The Journal of Infectious Diseases 198

      Pages: 1150-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine2008

    • Author(s)
      Kurashige, N, Hiramatsu, N, Ohkawa, K, et. al.
    • Journal Title

      Hepatol Res 38

      Pages: 450-456

    • NAID

      10024148320

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine.2008

    • Author(s)
      Kurashige N, Hiramatsu N, Ohkawa K, et. al.
    • Journal Title

      Hepatology Research 38

      Pages: 450-6

    • NAID

      10024148320

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Early emergence of entecavir-resistant hepatitis B virus in a patient with hepatitis B virus/human immunodeficiency virus coinfection.2008

    • Author(s)
      Kanada A, Takehara T, Ohkawa K, et al.
    • Journal Title

      Hepatol Res 38

      Pages: 622-8

    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Early emergence of entecavir-resistant hepatitis B virus in a patientwith hepatitis B virus/human immunodeficiency virus coinfection.2008

    • Author(s)
      Kanada A, Takehara T, Ohkawa K, et al.
    • Journal Title

      Hepatology Research 38

      Pages: 622-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Initial viral response is the most powerful predictor of the emergenceof YMDD mutant virus in chronic hepatitis B patients treated withlamivudine.2008

    • Author(s)
      Kurashige N, Hiramatsu N, Ohkawa K, et al.
    • Journal Title

      Hepatology Research 38

      Pages: 450-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Journal Article] Early emergence of entecavir-resistant hepatitis B virus in a patient with hepatitis B virus/human immunodeficiency virus coinfection.2008

    • Author(s)
      Kanada A, Takehara T, Ohkawa K, et. al.
    • Journal Title

      Hepatology Research (in press)

    • NAID

      10024149003

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFNalpha gene to mice. Int J Cancer 2007; 120 : 1252-60.2007

    • Author(s)
      Takehara T, Uemura A, Tatsumi T, Suzuki T, Kimura R, Shiotani A, Ohkawa K, et al.
    • Journal Title

      Int J Cancer 120 (6)

      Pages: 1252-1260

    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Type B fulminant hepatitis is closely associated with a highly mutated hepatitis B virus strain.2007

    • Author(s)
      Kanada A, Takehara T, Ohkawa K, et. al.
    • Journal Title

      Intervirology 50

      Pages: 394-401

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFN alpha gene to mice2007

    • Author(s)
      Takehara, T, Uemura, A, Tatsumi, T, Suzuki, T, Kimura, R, Shiotani, A, Ohkawa, K, et. al.
    • Journal Title

      Int J Cancer 120

      Pages: 1252-60

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Intrahepatic delivery of alpha-galactosylceramide-pulsed dendritic cells suppresses liver tumor2007

    • Author(s)
      Tatsumi T, Takehara T, Yamaguchi S, Sasakawa A, Sakamori R, Ohkawa, K, et. al.
    • Journal Title

      Hepatology 45

      Pages: 22-30

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFNalpha gene to mice.2007

    • Author(s)
      Takehara T, Uemura A, Tatsumi T, Suzuki T, Kimura R, Shiotani A, Ohkawa K, et. al.
    • Journal Title

      Int J Cancer 120

      Pages: 1252-60

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Intrahepatic delivery of alpha-galactosylceramide-pulsed dendritic cells suppresses liver tumor.2007

    • Author(s)
      Tatsumi T, Takehara T, Yamaguchi S, Sasakawa A, Sakamori R, Ohkawa K, et al.
    • Journal Title

      Hepatology 45 (1)

      Pages: 22-30

    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Type B fulminant hepatitis is closely associated with a highly mutated hepatitis B virus strain2007

    • Author(s)
      Kanada, A, Takehara, T, Ohkawa, K, et. al.
    • Journal Title

      Intervirology 50

      Pages: 394-401

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Journal Article] Intrahepatic delivery of a-galatosylceramide pulsed dendritic cells suppresses liver tumor2007

    • Author(s)
      Tatsumi, T, Takehara, T, Yamaguchi, S, Sasakawa, A, Sakamori, R, Ohkawa, K, et. al.
    • Journal Title

      Hepatology 45

      Pages: 22-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Presentation] 長期経過観察を経て肝炎を発症したHBe抗原陽性無症候性HBVキャリアの1症例におけるHBV全塩基配列の経時的変化とその病態的意義についての検討2010

    • Author(s)
      大川和良, ら
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Presentation] 9年間の経過観察を経て肝炎を発症したHBe抗原陽性無症候性HBVキャリアの1症例における各種HBVマーカーならびにHBV全塩基配列の経時的検討2009

    • Author(s)
      大川和良, ら
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-05
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Presentation] ラミブジンからエンテカビルへの切替症例におけるラミブジン非耐性B型慢性肝疾患の治療成績-OLF多施設共同研究2009

    • Author(s)
      倉繁奈緒、平松直樹、大川和良, ら
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Presentation] エンテカビル治療を施行したB型慢性肝疾患症例における薬剤耐性についての検討2009

    • Author(s)
      大川和良, ら
    • Organizer
      第13回日本肝臓学会大会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Presentation] OLF参加施設におけるB型慢性肝疾患に対する核酸アナログ療法の治療成績2008

    • Author(s)
      倉繁奈緒、平松直樹、大川和良, ら
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      松山
    • Year and Date
      2008-06-06
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Presentation] Supportive activity of precore and preS2 viral genomic changes against replication of lamivudine-resistant hepatitis B virus.2008

    • Author(s)
      大川和良, et al.
    • Organizer
      The 59th Annual Meeting of the American Association for the Study of Liver Diseases.
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-11-02
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Presentation] Supportive activity of precore and preS2 viral genomic changes against replication of lamivudine-resistant hepatitis B virus.2008

    • Author(s)
      Ohkawa K, et al.
    • Organizer
      The 59th Annual Meeting of the AmericanAssociation for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-11-02
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Presentation] OLF参加施設におけるB型慢性肝疾患に対するエンテカビルの治療成績2008

    • Author(s)
      倉繁奈緒、平松直樹、大川和良, ら
    • Organizer
      第12回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Presentation] ラミブジン耐性B型肝炎ウイルス成立機転に対するprecoreならびにpreS2変異の補助的役割2008

    • Author(s)
      大川和良, ら
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      松山
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-20590776
  • [Presentation] VIRAL MUTATIONS AFFECTING EFFICACY OF ADEFOVIR DIPIVOXIL THERAPY ADDED TO ONGOING LAMIVUDINE IN CHRONIC HEPATITIS B2007

    • Author(s)
      大川和良, ら
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Presentation] B型急性肝炎と劇症肝炎におけるB型肝炎ウイルスDNA全塩基配列の比較2007

    • Author(s)
      金田愛衣美、竹原徹郎、大川和良, ら
    • Organizer
      第93回日本消化器病学会総会
    • Place of Presentation
      青森
    • Year and Date
      2007-04-19
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Presentation] ラミブジン耐性B型慢性肝炎に対するアデホビル追加治療におけるウイルス変異の意義2007

    • Author(s)
      大川和良, ら
    • Organizer
      第11回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-19
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Presentation] ラミブジン耐性B型慢性肝疾患に対するアデホビル追加治療における治療効果を規定するウイルス変異の検討2007

    • Author(s)
      大川和良, ら
    • Organizer
      第43回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Presentation] Viral mutations affecting efficacy of adefovir dipivoxil therapy added to ongoing lamivudine in chronic hepatitis B2007

    • Author(s)
      Ohkawa, K, et. al.
    • Organizer
      The 67th annual meeting of Japanese Cancer Association
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Presentation] VIRAL MUTATIONS AFFECTING EFFICACY OF ADEFOVIR DPIVOXIL THERAPY ADDED TO ONGOING LAMIVUDINE IN CHRONIC HEPATITIS B2007

    • Author(s)
      大川和良, ら
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Presentation] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine.2006

    • Author(s)
      Kurashige N, Hiramatsu N, Ohkawa K, et. al.
    • Organizer
      57th meeting of the American Association of the Study of Liver Diseases.
    • Place of Presentation
      Boston
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18599003
  • [Presentation] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in hepatitis B patients treated with lamivudine2006

    • Author(s)
      Kurashige, N, Hiramatsu, N, Ohkawa, K, et. al.
    • Organizer
      The 57th annual meeting of the American Association of the Study of Liver Diseases
    • Place of Presentation
      Boston, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18599003
  • 1.  TAKEHARA Tetsuo (70335355)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 2.  TATSUMI Tomohide (20397699)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  HIRAMATSU Naoki (30362700)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results

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