Mizuno Yusuke 水野祐介

… Alternative Names

MIZUNO Yusuke 水野祐介

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Researcher Number	80433192
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 附属病院, 准教授
Affiliation (based on the past Project Information) *help	2025: 横浜市立大学, 附属病院, 准教授 2015 – 2023: 横浜市立大学, 附属病院, 准教授 2015: 横浜市立大学, 大学病院, 准教授 2013 – 2014: 横浜市立大学, 医学部, 講師 2012: 横浜市立大学, 附属病院, 講師 … More 2011: 横浜市立大学, 医学部, 講師 2010: 横浜市立大学, 医学部・麻酔科, 講師 2008 – 2010: Yokohama City University, 医学部, 助教 2009: 横浜市立大学, 大学院・医学研究科, 助教 2007: Yokohama City University, 医学研究科, 助教 2006: 横浜市立大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Anesthesiology Except Principal Investigator Anesthesiology / Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Medical Physics/Radiological Technology
Keywords	Principal Investigator 肺高血圧 / 肺高血圧症 / ROCK / 血管平滑筋 / protein kinase D / 血管収縮 / カルシウム / 核酸医薬 / protein kinase d / PKC … More / protain kinase D / アクチン / 平滑筋 / actin / MYPT1 / Protein kinase D / MSC / ＭＳＣ / ＶＰＡＣ２ / VPAC2アゴニスト / 間葉系幹細胞 / VIP / VPAC2 / 肺血管平滑筋 / pulmonary hypertension / CPI-17 / ＭＬＣＫ / desensitization / リン酸化 / MLCK / エレクトロポレーション / H0-1 / PACAP/VIP / レンチウイルスベクター / プラスミドベクター / HO-1 / PACAP / 遺伝子治療 / siRNA / Rho-kinase / シグナル伝達 / 低酸素性肺血管収縮 … More Except Principal Investigator 肺高血圧 / 肺高血圧症 / 肺高血圧クライシス / arginase / 一酸化窒素合成酵素 / 内皮細胞 / 一酸化窒素 / 肺血管抵抗 / ＶＰＡＣ２ / VPAC2 / ＶＩＰ / PACAP / VIP / レンチウイルス / 右心肥大 / β adrenergic 作用 / vasopressin / DPC / 診療群分類包括評価（DPC） / 診療群分類包括評価 / 陽性変力変時作用薬 / 血管収縮薬 / 超音波ドプラー測定 / Windlessel 3要素model / インピーダンス測定 / 肺動脈コンプライアンス / Windkessel model / windkessel / モノクロタリン / Windkessel / インピーダンス / 間質系幹細胞 / drug delivery / microRNA / 臍帯血由来間葉系幹細胞 / miRNA / exosome / 間葉系幹細胞 / 平滑筋 / 内皮由来一酸化窒素合成酵素 / arginine / eNOS / ＰＲＭＴ２ / ＤＤＡＨ１ / 内因性NOS阻害物質 / ＡＤＡＭ / 一酸化窒素合成酵素阻害物質 / DDAH / ADMA / 心拍出量 / lentivirus / pumonary hypertension / ＰＡＣＡＰ / 心臓神経 / PAC1 / 右室肥大 / インターベンショナルラジオロジー / 国際放射線防護委員会 / 診断参考レベル / 皮膚透過線量 / 蛍光ガラス線量計 / 医療被ばく / インターベンショナル・ラジオロジー / プラスミドベクター / 心肥大 / 遺伝子治療 / 心臓神経叢 / PACAP/VIP / ニューロン / 細胞内Ga濃度 / エリスロポイエチン / 細胞内Ca濃度 / 細胞内カルシウム濃度 / イオンチャネル / エリスロポエチン / 神経保護 Less

肺高血圧症におけるフェロトーシスとprotein kinase Dの役割の解明Principal Investigator
- Principal Investigator
  
  水野祐介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Yokohama City University
Multifaceted approaches for pulmonary hypertensive crisis
- Principal Investigator
  
  渡辺至
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Yokohama City University
Protein kinase Dの肺高血圧症への関与解明と核酸医薬による制御Principal Investigator
- Principal Investigator
  
  水野祐介
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Yokohama City University
重症肺高血圧モデルラットを用いた肺動脈コンプライアンスの検討および治療戦略の確立
- Principal Investigator
  
  菅原陽
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Yokohama City University
Role of protein kinase D in vasoconstrictionPrincipal Investigator
- Principal Investigator
  
  MIZUNO Yusuke
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Yokohama City University
Exosome of mesenchymal stem cells for the treatment of pulmonary hypertension with microRNA.
- Principal Investigator
  
  WATANABE Itaru
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Yokohama City University
Inhibitory effect of arginase on pulmonary hypertension
- Principal Investigator
  
  Shinbori Nobuhiro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Yokohama City University
Treatment for PH with VPAC2 agonist vectorPrincipal Investigator
- Principal Investigator
  
  MIZUNO Yusuke
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Yokohama City University
Role of VPAC2 receptor in monocrotaline-induced pulmonary hypertensionin in rats
- Principal Investigator
  
  KAWAKAMI Hiromasa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Yokohama City University
Effect of endogenous NOS inhibitor on pulmonary arterial pressure
- Principal Investigator
  
  Shinbori Nobuhiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Yokohama City University
Usege of lentiviral vector for treatment of pulmonary hypertension
- Principal Investigator
  
  WATANABE Itaru
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yokohama City University
calcium sensitization in pulmoary hypertensionPrincipal Investigator
- Principal Investigator
  
  MIZUNO Yusuke
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yokohama City University
Involvement of VIP Signaling in Right Cardiac Hypertrophy
- Principal Investigator
  
  WATANABE Itaru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yokohama City University
Standardization of patient dosimetry for interventional radiology
- Principal Investigator
  
  MORITAKE Takashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical Physics/Radiological Technology
- Research Institution
  University of Tsukuba
Gene therapy for treatment of pulmonary hypertension using plasmid vectorPrincipal Investigator
- Principal Investigator
  
  MIZUNO Yusuke
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yokohama City University
Novel mechanisms for neuroprotective actions of erythropoietin
- Principal Investigator
  
  ANDOH Tomio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yokohama City University
低酸素性肺血管収縮におけるカルシウム依存性、非依存性収縮の機序解明Principal Investigator
- Principal Investigator
  
  水野祐介
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yokohama City University

All 2024 2021 2014 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Role of protein kinase D1 in vasoconstriction and haemodynamics in rats2024
- Author(s)
  Sugawara Yoh、Mizuno Yusuke、Oku Shinya、Sawada Yuri、Goto Takahisa
- Journal Title
  
  Microvascular Research
  
  Volume: 152 Pages: 104627-104627
- DOI
  10.1016/j.mvr.2023.104627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09225
[Journal Article] Role of VPAC2 receptor in monocrotaline-induced pulmonary hypertension in rats2014
- Author(s)
  Motokazu Koga , Yusuke Mizuno , Itaru Watanabe , Hiromasa Kawakami , Takahisa Goto
- Journal Title
  
  Journal of Applied Physiology
  
  Volume: Vol. 117 no. 4 Issue: 4 Pages: 383-391
- DOI
  10.1152/japplphysiol.00861.2013
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592309
[Journal Article] Involvement of increased protein arginine methyltransferases 2 and decreased dimethylarginine dimethylaminohydrolases in impaired NOS activity in pulmonary hypertension in rats2014
- Author(s)
  Yusuke Mizuno, Nobuhiro Shinbori, Takahisa Goto
- Journal Title
  
  European Journal of Anaesthesiology
  
  Volume: 31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592304
[Journal Article] Precise mapping system of entrance skin dose during endovascular embolization for cerebral aneurysm2011
- Author(s)
  Moritake T, Hayakawa M, MatsumaruY, Takigawa T, Koguchi Y, Miyamoto Y, Mizuno Y, Chida K, Akahane K, TsuboiK, Sakae T, Sakurai H
- Journal Title
  
  Radiation Measurements
  
  Volume: 46 Pages: 2103-2106
- URL
  http://dx.doi.org/10.1016/j.radmeas.2011.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21611012
[Journal Article] Altered expression in pituitary adenylate cyclase-activating Polypeptide and its receptors in monocrotaline - induced pulmonary hypertension in rats2011
- Author(s)
  Mizuno Y, Koga M, Irie T, Goto T
- Journal Title
  
  Eur. J. Anaesthesiol
  
  Volume: Vol28 Pages: 67-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591981
[Presentation] 低酸素誘発性肺高血圧クライシス動物モデルにおけるドブタミン単剤投与の有効性の検討2021
- Author(s)
  奥信哉　澤田侑里　水野祐介　菅原陽　後藤隆久
- Organizer
  日本麻酔科学会第６８回
- Data Source
  KAKENHI-PROJECT-17K11058
[Presentation] モノクロタリン誘発肺高血圧症ラットの肺動脈におけるprotein kinase Dの役割の解明2021
- Author(s)
  奥真哉, 長嶺祐介, 菅原陽, 水野祐介, 後藤隆久
- Organizer
  日本心臓麻酔学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11058
[Presentation] モノクロタリン誘発肺高血圧症ラットの肺動脈におけるprotein kinase Dの役割の解明2021
- Author(s)
  奥真哉、長嶺祐介、菅原陽、水野祐介、後藤隆久
- Organizer
  日本心臓麻酔学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09225
[Presentation] 血管作動性腸ペプチド受容体２のモノクロタリン投与肺高血圧ラットにおける役割2014
- Author(s)
  古賀資和、水野祐介、柏木静、渡邊至、後藤隆久
- Organizer
  日本麻酔科学会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-25462446
[Presentation] Involvement of increased protein arginine methyltransferases 2 and decreased dimethylarginine dimethylaminohydrolases in impaired NOS activity in pulmonary hypertension in rats2014
- Author(s)
  Yusuke Mizuno, Nobuhiro Shinbori, Takahisa Goto
- Organizer
  Euroanesthesia
- Place of Presentation
  Stockholm Sweden
- Year and Date
  2014-06-01
- Data Source
  KAKENHI-PROJECT-23592304
[Presentation] Effect of VPAC2 Agonist on Improving Cardiac Output2013
- Author(s)
  Yusuke Mizuno, Motokazu Koga, Shizuka Kashiwagi, Itaru Watanabe, Takahisa Goto
- Organizer
  Experimental Biology
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23592304
[Presentation] Effect of VPAC2 Agonist on Improving Cardiac Output2013
- Author(s)
  Yusuke Mizuno, Motokazu Koga, Shizuka Kashiwagi, Itaru Watanabe, Takahisa Goto
- Organizer
  Experimental Biology
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-24592309
[Presentation] Involvement of PACAP Signaling in Right Cardiac Hypertrophy Induced With Monocrotaline in Rats2012
- Author(s)
  Motokazu Koga, Yusuke Mizuno, Hiromasa Kawakami, Itaru Watanabe, Takahisa Goto
- Organizer
  American Society of Anesthesiologists. Annual nleeting 2012
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2012-10-14
- Data Source
  KAKENHI-PROJECT-21591981
[Presentation] Altered expression in pituitary adenylate cyclase-activating polypeptide and its receptors in monocrotaline-induced pulmonary hypertension in rats2011
- Author(s)
  Yusuke Mizuno, Motokazu Koga, Tomoya, Irie, Kakahisa Goto
- Organizer
  European Society of Anesthesiologists
- Place of Presentation
  Euroanesthesia 2011 Amsterdam Netherlands
- Data Source
  KAKENHI-PROJECT-20591810
[Presentation] Altered expression in pituitary adenylate cyclase-activatin polypeptide and its receptors in monocrotaline-induced pulmonary hypertension in rats2011
- Author(s)
  Yusuke Mizuno
- Organizer
  European society of Anesthesiologysts, Annual Meeting
- Place of Presentation
  Amsterdam RAI Convention Centre, Netherland
- Year and Date
  2011-06-12
- Data Source
  KAKENHI-PROJECT-21591981
[Presentation] HO-1 expression attenuates monocrotaline-induced pulmonary hypertension through toll-like receptor 4 signaling2011
- Author(s)
  水野祐介、川上裕理、古賀資和、後藤隆久
- Organizer
  日本麻酔科学会59回学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20591810
[Presentation] Precise mapping of entrance skin dose during endovascular embolization for cerebral aneurysm to avoid radiation-inducedskin injury2010
- Author(s)
  Moritake T, Hayakawa M, MatsumaruY, Takigawa T, Koguchi Y, Miyamoto Y, Mizuno Y, Chida K, Akahane K, TsuboiK, Sakae T, Sakurai H
- Organizer
  16^<th> International Conference on Solid State Dosimetry, Sydney, Australia
- Data Source
  KAKENHI-PROJECT-21611012
[Presentation] Precise mapping of entrance skin dose during neurointerventional procedure : what isthe most effective method to avoid radiation-induced skin injury?2010
- Author(s)
  Moritake T, Hayakawa M, MatsumaruY, Koguchi Y, Miyamoto Y, Mizuno Y, Chida K, Akahane K, Tsuboi K, Sakae Tand Sakurai H
- Organizer
  56^<th>Annual Meeting Radiation ResearchSociety, Maui, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-21611012
[Presentation] Attenuation of monocrotaline-induced pulmonary hypertension by heme oxygenase-1 involves Toll-like receptor 4 signaling2010
- Author(s)
  Hiromasa Kawakami, Yusuke Mizuno, Motokazu Koga, Takahisa Goto
- Organizer
  European Society of Anesthesiologists
- Place of Presentation
  Euroanesthesia 2010 Helsinki Finland
- Data Source
  KAKENHI-PROJECT-20591810
[Presentation] Altered Expression of VIP/VPAC2 in Hypertrophic Right Ventricle Induced with Monocrotaline in Rats2009
- Author(s)
  Motokazu Koga, Hiromasa Kawakami, Yusuke Mizuno et al.
- Organizer
  American Society of Anesthesiologists Annual meeting 2009
- Place of Presentation
  New Orleans, USA
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21591981

1. WATANABE Itaru (20534142)

# of Collaborated Projects: 9 results

# of Collaborated Products: 5 results
2. KAWAKAMI Hiromasa (90407958)

# of Collaborated Projects: 9 results

# of Collaborated Products: 5 results
3. 古賀資和 (00637233)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. BABA Yasuko (80453041)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. Shinbori Nobuhiro (60404993)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 菅原陽 (00596413)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
7. ANDOH Tomio (00193110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ECHIGO Noriyuki (00363797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAMIYA Yoshitaka (90381491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MORITAKE Takashi (50450432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. SAKAE Takeji (60162278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. CHIDA Koichi (20323123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. MATSUMARU Yuji (70323300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. HAYAKAWA Mikito (80450229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. Miura Norikazu (50448677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 新井悠介 (30828554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mizuno Yusuke 水野 祐介

MIZUNO Yusuke 水野 祐介

Research Projects

Research Products

Co-Researchers

肺高血圧症におけるフェロトーシスとprotein kinase Dの役割の解明Principal Investigator

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Protein kinase Dの肺高血圧症への関与解明と核酸医薬による制御Principal Investigator

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Role of protein kinase D in vasoconstrictionPrincipal Investigator

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Treatment for PH with VPAC2 agonist vectorPrincipal Investigator

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calcium sensitization in pulmoary hypertensionPrincipal Investigator

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Mizuno Yusuke 水野祐介

MIZUNO Yusuke 水野祐介