OHSHIMA Hiroshi 大島寛史

Researcher Number	80433209
Affiliation (based on the past Project Information) *help	2009 – 2014: University of Shizuoka, 食品栄養科学部, 教授 2006 – 2007: 静岡県立大学, 食品栄養科学部, 教授
Review Section/Research Field	Principal Investigator Eating habits, studies on eating habits
Keywords	Principal Investigator 生活習慣病 / コレステロール / ozone / chronic inflammation / metabolic syndrome / reactive oxygen and nitrogen species / cholesterol / オゾン / 慢性炎症 / メタボリック症候群 … More / 活性酸素・窒素酸化物 / アルデヒド / オゾン酸化コレステロール / 健康と食生活 / ミエロペルオキシダーゼ / 好中球 / オゾン酸化 / 分析科学 / 栄養学 / 炎症 / 脂質 Less

Ozone-oxidized cholesterols as biomarkers for metabolic syndrome and life-style related diseasesPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  University of Shizuoka
Elucidations of the mechanisms for the formation of cholesterol-ozonolysis products in inflamed tissues, their biological activities and involvement in disease developmentPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  University of Shizuoka
Identification of inflammation-mediated oxidized cholesterols as novel biomarkers of the metabolic syndromePrincipal Investigator
- Principal Investigator
  
  OHSHIMA Hiroshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  University of Shizuoka

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] 酸化ストレスの医学2014
- Author(s)
  大島寛史。三好規之、伴野勧
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-24300257
[Book] CANCER AND INFLAMMATION MECHANISMS　Chemical, Biological and Clibical Asdpects2014
- Author(s)
  Hiraku Y, Kawanishi S, Ohshima H
- Total Pages
  383
- Publisher
  John Wiley & Sons
- Data Source
  KAKENHI-PROJECT-24300257
[Book] 基礎生化学-健康・疾病とのつながり-2013
- Author(s)
  永井竜児、大島寛史(編)
- Total Pages
  259
- Publisher
  アイ・ケイコーポレーション
- Data Source
  KAKENHI-PROJECT-24300257
[Book] 抗ストレス食品の開発と展望II2012
- Author(s)
  大島寛史, ら
- Total Pages
  295
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21300280
[Book] Inflammation Induced Carcinogenesis and Chemoprevention. Chemoprevention of Cancer and DNA Damage by Dietary Factors2009
- Author(s)
  Ohshima H., Miyoshi N., et al.
- Publisher
  WILEY-BLACKWELL
- Data Source
  KAKENHI-PROJECT-21300280
[Book] Inflammation Induced Carcinogenesis and Chemoprevention2008
- Author(s)
  Ohshima, H., Tomono, S., Lai, Y-L., Miyoshi, N
- Publisher
  Knasmuller,S.DeMarini,D.M.,Johnson,IT.& Gerhauser(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Book] がん予防『酸化ストレスの医学』2008
- Author(s)
  大島寛史, 三好規之
- Publisher
  診断と治療社(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Book] Inflammation Induced Carcinogenesis and Chemoprevention.2008
- Author(s)
  H. Ohshima, S. Tomono, Y-L. Lai, and N. Miyoshi
- Publisher
  Knasmuller, S. DeMarini, D.M., Johnson, I.T. & Gerhauser(in press)
- Data Source
  KAKENHI-PROJECT-18509001
[Book] がん予防『酸化ストレスの医学』2008
- Author(s)
  大島寛史, 三好規之
- Publisher
  診断と治療社(印刷中)
- Data Source
  KAKENHI-PROJECT-18509001
[Book] 三好規之ら、がん予防と酸化ストレス、酸化ストレスの医学2008
- Author(s)
  大島寛史
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitric-oxide-mediated cyclooxygenase 2 activation2015
- Author(s)
  Wada S, Matsushita Y, Tazawa H, Aoi, W Naito Y, HIgashi H, Ohshima H, Yoshikawa T
- Journal Title
  
  Free Radic Res
  
  Volume: 49 Issue: 3 Pages: 269-278
- DOI
  10.3109/10715762.2014.997230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-25450175
[Journal Article] Comprehensive analysis of the lipophilic reactive carbonyls present in biological specimens by LC/ESI-MS/MS2015
- Author(s)
  Tomono S, Miyoshi N, Ohshima H
- Journal Title
  
  J Chromatogrphy B
  
  Volume: 988 Pages: 149-156
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300257
[Journal Article] Implications of cholesterol autoxidation products in the pathogenesis of inflammatory diseases2014
- Author(s)
  Miyoshi N, Iuliano L, Tomono S, Ohshima H.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 446 Issue: 3 Pages: 702-708
- DOI
  10.1016/j.bbrc.2013.12.107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-24700838, KAKENHI-PROJECT-25560057
[Journal Article] Cytotoxic Effects of Secosterols and Their Derivatives on Several Cultured Cells2013
- Author(s)
  Tomono S
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 77 Issue: 3 Pages: 651-653
- DOI
  10.1271/bbb.120758
- NAID
  10031164790
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650486, KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-24700838
[Journal Article] Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low density lipoprotein.2013
- Author(s)
  Miyoshi N, Iwasaki N, Tomono S, Higashi T, Ohshima H.
- Journal Title
  
  Free Radic.Biol.Med.
  
  Volume: 60 Pages: 73-79
- DOI
  10.1016/j.freeradbiomed.2013.01.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-24700838, KAKENHI-PROJECT-25560057
[Journal Article] Analysis of N^ε-ethyllysine in human plasma proteins by gas chromatography-negative ion chemical ionization/mass spectrometry as a biomarker for exposure to acetaldehyde and alcohol2012
- Author(s)
  Mabuchi R, Kurita A, Miyoshi N, Yokoyama A, Furuta T, Goda T, Suwa Y, Kan T, Amagai T, Ohshima H
- Journal Title
  
  Alcohol.Clin.Exp.Res.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Analysis of N^ε-ethyllysine in human plasma proteins by gas chromatography-negative ion chemical ionization/mass spectrometry as a biomarker for exposure to acetaldehyde and alcohol2012
- Author(s)
  Mabuchi R., et al.
- Journal Title
  
  Alcohol.Clin.Exp.Res.
  
  Volume: (印刷中) Issue: 6 Pages: 1013-1020
- DOI
  10.1111/j.1530-0277.2011.01705.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21680052, KAKENHI-PROJECT-22350070, KAKENHI-PROJECT-23650486, KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075
[Journal Article] Dysregulation of dimethylargininedimethylaminohydrolase/asymmetric dimethylarginine pathway in rat type II diabetic nephropathy2012
- Author(s)
  Miyoshi N
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 51 Issue: 2 Pages: 143-149
- DOI
  10.3164/jcbn.11-33
- NAID
  130004879298
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650486, KAKENHI-PROJECT-23790747, KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-24700838
[Journal Article] Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells2012
- Author(s)
  Miyoshi, N., Yonemochi, T., Tomono, S., Fukutomi, R., Nakamura, Y., Ohshima, H.
- Journal Title
  
  Anal. Biochem.
  
  Volume: 429(2) Issue: 2 Pages: 124-131
- DOI
  10.1016/j.ab.2012.07.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580129, KAKENHI-PROJECT-23650486, KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-24700838
[Journal Article] Dysregulation of dimethylargininedimethylaminohydrolase/asymmetricdi methylarginine pathway in rat type II diabetic nephropathy2012
- Author(s)
  Lai YL, Aoyama S, Ohata M, Otsuka N, Shiokawa H, Tomono S, Fujiwara Y, Kanazawa H, Miyoshi N, Ohshima H
- Journal Title
  
  J.Clin.Biochem.Nutr.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Analysis of Nε-ethyllysine in human plasma proteins by gas chromatography-negative ion chemical ionization/mass spectrometry as a biomarker for exposure to acetaldehyde and alcohol2012
- Author(s)
  Mabuchi R, Kurita A, Miyoshi N, Yokoyama A, Furuta T, Goda T, Suwa Y, Kan T, Amagai T, Ohshima H
- Journal Title
  
  Alcohol. Clin. Exp. Res.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] The enhancement of the oral bioavailability of γ-tocotrienol in mice by γ-cyclodextrin inclusion2011
- Author(s)
  Miyoshi N, Wakao Y, Tomono S, Tatemichi M, Yano T, Ohshima H
- Journal Title
  
  J.Nutr.Biochem.
  
  Volume: 22 Issue: 12 Pages: 1121-1126
- DOI
  10.1016/j.jnutbio.2010.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin2011
- Author(s)
  Miyoshi N, Nagasawa T, Mabuchi R, Yasui Y, Wakabayashi K, Tanaka T, Ohshima H
- Journal Title
  
  Cancer Prev.Res.
  
  Volume: 4 Pages: 924-934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases2011
- Author(s)
  Lai YL, Tomono S, Miyoshi N, Ohshima H
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 50 Issue: 1 Pages: 84-89
- DOI
  10.3164/jcbn.11-31
- NAID
  130004466675
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280, KAKENHI-PROJECT-24300257
[Journal Article] A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine2011
- Author(s)
  Tomono S, Miyoshi N, Ito M, Higashi T, Ohshima H
- Journal Title
  
  J. Chromatogr. B
  
  Volume: 879 Issue: 26 Pages: 2802-2802
- DOI
  10.1016/j.jchromb.2011.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280, KAKENHI-PROJECT-21680052, KAKENHI-PROJECT-23650486
[Journal Article] Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde : Implications for vascular and neurodegenerative diseases.2011
- Author(s)
  Lai Y-L, Tomono S, Miyoshi N, Ohshima H.
- Journal Title
  
  J.Clin.Biochem.Nutr.
  
  Volume: (印刷中)
- NAID
  130004466675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin.2011
- Author(s)
  Miyoshi N, Nagasawa T, Mabuchi R, Yasui Y, Wakabayashi K, Tanaka T, Ohshima H.
- Journal Title
  
  Cancer Prev.Res.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] The enhancement of the oral bioavailability of Y-tocotorienol in mice by Y-cyclodextrin inclusion.2011
- Author(s)
  Miyoshi N, Wakao Y, Tomono S, Tatemichi M, Yano T, Ohshima H.
- Journal Title
  
  J Nutr.Biochem.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway.2011
- Author(s)
  Tomono S, Miyoshi N, Shiokawa H, Iwabuchi T, Aratani Y, Higashi T, Nukaya H, Ohshima H.
- Journal Title
  
  J.Lipid Res.
  
  Volume: 52 Pages: 87-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway2011
- Author(s)
  Tomono S, Miyoshi N, Shiokawa H, Iwabuchi T, Aratani Y, Higashi T, Nukaya H, Ohshima H
- Journal Title
  
  J. Lipid Res.
  
  Volume: 52 Issue: 1 Pages: 87-97
- DOI
  10.1194/jlr.m006775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Inhibition of L-Arginine Metabolizing Enzymes by L-Arginine-derived Advanced Glycation End Products.2010
- Author(s)
  Lai Y-L, Aoyama S, Nagai R, Miyoshi N, Ohshima H.
- Journal Title
  
  J Clin Biochem Nutr.
  
  Volume: 46 Pages: 177-185
- NAID
  130004466608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Ingested Nitrate and Nitrite : Beneficial to Human Health?2010
- Author(s)
  Ohshima H, Miyoshi N.
- Journal Title
  
  Genes Environm.
  
  Volume: 32 Pages: 43-52
- NAID
  10026643559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Inhibitation of L-Arginine Metabolizing Enzymes by L-Arginine-derived Advanced Glycation End Products2010
- Author(s)
  Lai Y-L, Aoyama S, Nagai R, Miyoshi N, Ohshima H.
- Journal Title
  
  J.Clin.Biochem.Nutr. 46
  
  Pages: 177-185
- NAID
  130004466608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Formation of cholesterol ozonolysis products through an ozone-free mechanism mediated by the myeloperoxidase-H_2O_2-chloride system. Biochem2009
- Author(s)
  Tomono S, Miyoshi N, Sato K, Ohba Y, Ohshima H
- Journal Title
  
  Biophys. Res. Commun
  
  Volume: 383 Issue: 2 Pages: 222-222
- DOI
  10.1016/j.bbrc.2009.03.155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Formation of cholesterol ozonolysis products through an ozone-free mechanism mediated by the myeloperoxidase-H_2O_2-chloride system2009
- Author(s)
  Tomono S, Miyoshi N, Sato K, Ohba Y, Ohshima H
- Journal Title
  
  Biochem.Biophys.Res.Commun. 383
  
  Pages: 222-227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters2008
- Author(s)
  Sawa, T., Ohshima, et. al.
- Journal Title
  
  Cancer Letters (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters2008
- Author(s)
  Sawa, T., Ohshima, H., et. al.
- Journal Title
  
  Cancer Letters (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Geographic Distribution of Liver and Stomach Cancers in Thailand in Relation to Estimated Dietary Intake of Nitrate, Nitrite, and Nitrosodimethylamine2008
- Author(s)
  Mitacek, E. J., Ohshima, H., et. al.
- Journal Title
  
  Nutrition and Cancer 60(2)
  
  Pages: 196-203
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Geographic Distribution of Liver and Stomach Cancers in Thailand in Relation to Estimated Dietary Intake of Nitrate, Nitrite, and Nitrosodimethylamine.2008
- Author(s)
  E. J. Mitacek, K. D. Brunnemann, M. Suttajit, L. S. Caplan, C. E. Gagna, K. Bhothisuwan, S. Siriamornpun, C. F. Hummel, H. Ohshima, R. Roy, and N. Martin
- Journal Title
  
  Nutrition and Cancer 60
  
  Pages: 196-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters.2008
- Author(s)
  Sawa, T., Mounawar, M., Tatemichi, M., Gilibert, I., Katoh, T. & Ohshima, H.
- Journal Title
  
  Cancer Letters (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Geographic Distribution of Liver and Stomach Cancers in Thailand in Relation to Estimated Dietary Intake of Nitrate,Nitrite,and Nitrosodimethylamine2008
- Author(s)
  Mitacek, E.J., Ohshima, H., et. al.
- Journal Title
  
  Nutrition and Cancer 60
  
  Pages: 196-203
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Inflammation Induced Carcinogenesis and Chemoprevention2008
- Author(s)
  H. Ohshima, S. Tomono, Y-L. Lai, N. Miyoshi
- Journal Title
  
  Inflammation Induced Carcinogenesis and Chemoprevention (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerate sarcoma development in Trp53+/-mice2007
- Author(s)
  Tazawa, H., Ohshima, H., et. al.
- Journal Title
  
  Carcinogenesis 28(1)
  
  Pages: 191-198
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Oxidative and nitrative stress caused by subcutaneous implantation of aforeign body accelerate sarcoma development in Trp53+/- mice2007
- Author(s)
  Tazawa, H., Tatemichi, M., Sawa, T., Gilibert, I., Ma, N., Hiraku, Y., Donehower, L. A., Ohgaki, H., Kawanishi, S.&Ohshima, H
- Journal Title
  
  Carcinogenesis. 28(1)
  
  Pages: 191-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerate sarcoma development in Trp53+/- mice2007
- Author(s)
  Tazawa, H., Ohshima, H., et. al.
- Journal Title
  
  Carcinogenesis 28(1)
  
  Pages: 191-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerate sarcoma development in Trp53+/- mice2007
- Author(s)
  Tazawa, H., Ohshima, H., et al.
- Journal Title
  
  Carcinogenesis 28(1)
  
  Pages: 198-198
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] 8-Nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species : formation, occurrence and implications in inflammation and carcinogenesis2006
- Author(s)
  Ohshima, H., Sawa, T., Akaike, T.
- Journal Title
  
  Antioxidants ＆ Redox Signaling 8(5-6)
  
  Pages: 1033-1033
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Analysis of urinary 8-nitroguanine, a marker of nitrative nucleic acid damage, by high-performance liquid chromatography-electrochemical detection coupled with immunoaffinity purification : Association with cigarette smoking2006
- Author(s)
  Sawa, T., Ohshima, H., et al.
- Journal Title
  
  Free Radic. Biol. Med. 40(4)
  
  Pages: 711-711
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Differences in oxidative stress dependence between gastric adenocarcinoma subtypes2006
- Author(s)
  Bancel, B., Ohshima, H., et al.
- Journal Title
  
  World J. Gastroenterol 12(7)
  
  Pages: 1005-1005
- Data Source
  KAKENHI-PROJECT-18509001
[Journal Article] Nitrative DNA damage in inflammation and its possible role in carcinogenesis2006
- Author(s)
  Sawa, T., Ohshima, H.
- Journal Title
  
  Nitric Oxide : Biol. ＆ Chem. 14(2)
  
  Pages: 91-91
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] KK-Ayマウスにおける山薬および有効成分ジオスゲニンの血中トリグリセライド低下作用2014
- Author(s)
  三好規之、佐々木香、三浦信司、大島寛史
- Organizer
  日本農芸化学会2014
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 植物ホルモン様ペプチドleginsulinの動物細胞に対する機能性解析2014
- Author(s)
  坂野太研、伴野勧、大島寛史、三好規之、
- Organizer
  日本農芸化学会2014
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Global analysis of reactive carbonyls formed in neuronal PC-12 cells by exposed to amyloid-beta2014
- Author(s)
  Susumu Tomono, Misa Nagasawa, Noriyuki Miyoshi, Hiroshi Ohshima.
- Organizer
  SFRR-international 2014
- Place of Presentation
  Kyoto,Japan
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Denaturation of cellular proteins induced by secosterol aldehydes2014
- Author(s)
  Noriyuki Miyoshi, Susumu Tomono, Hiroshi Ohshima.
- Organizer
  SFRR-international 2014
- Place of Presentation
  Kyoto,Japan
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] ob/obマウス糞便に含まれる起炎症性分子の探索2014
- Author(s)
  眞田峻佑、大島寛史、三好規之
- Organizer
  日本農芸化学会2014
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 青大豆に含まれる植物ホルモン様ペプチドleginsulinの解析2013
- Author(s)
  坂野太研、三好規之、池本裕之、今井伸二郎、大島寛史
- Organizer
  JSoFF 2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Search as novel diagnostic biomarkers for fecal small molecules responsible for metabolic syndrome in ob/ob mice2013
- Author(s)
  Shunsuke Sanada, Shoko Hirukawa, Noriyuki Miyoshi, Hiroshi Ohshima.
- Organizer
  静岡健康・長寿学術フォーラム
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Cholesterol aldehydes: The mechanisms of their formation and pahological roles in oxidative stress related-disorders2013
- Author(s)
  Noriyuki Miyoshi, Susumu Tomono, Hiroshi Ohshima.
- Organizer
  3rd European Network for Oxysterol Research
- Place of Presentation
  Swansea, UK
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] LC/ESI-MS/MSによる肥満・糖尿病モデルマウス（ob/ob）血漿中アルデヒドの網羅的解析Comprehensive analysis of aldehydes in obese/diabetes ob/ob mice plasma using LC/ESI-MS/MS2013
- Author(s)
  伴野勧、長澤美沙、村田晴美、眞田峻介、三好規之、大島寛史
- Organizer
  第85回日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Identification of carcinogenic compounds formed by chronic ethanol feeding in feces of mice2013
- Author(s)
  Shoko Hirukawa, Shunsuke Sanada, Noriyuki Miyoshi, Hiroshi Ohshima.
- Organizer
  静岡健康・長寿学術フォーラム
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 食後の血中脂質に対するヤムイモおよびその含有成分ジオスゲニンの効果2013
- Author(s)
  三好規之、平田隼、新井英一、大島寛史
- Organizer
  日本農芸化学会2013
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Conprehensive analytical method for lipophilic reactive carbonyl compounds in biological samples2013
- Author(s)
  Susumu Tomono, Noriyuki Miyoshi, Hiroshi Ohshima.
- Organizer
  SFRR-Europe 2013 Conference
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] ob/obマウス糞便抽出物の分析によるメタボリック症候群新規診断バイオマーカーの探索2013
- Author(s)
  眞田峻佑、蛭川頌子、大島寛史、三好規之
- Organizer
  日本農芸化学会2013
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 飲酒によって変動するマウス糞便中化合物の探索2013
- Author(s)
  蛭川頌子、眞田峻佑、大島寛史、三好規之
- Organizer
  日本農芸化学会2013
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 神経細胞様分化PC-12へのamyloid-β曝露によって生成されるアルデヒド類の網羅的解析Comprehensive analysis of aldehydes formed in neuronal differenciated PC-12 cells by exposureto amyloid-β2013
- Author(s)
  長澤美沙、伴野勧、三好規之、大島寛史
- Organizer
  第85回日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Acetaldehyde-modification of dehydrogenase/reductase member 2 decrease its binding to Mdm22013
- Author(s)
  Yuji Yamada, Aya Kurita, Susumu Tomono, Noriyuki Miyoshi, Hiroshi Ohshima.
- Organizer
  静岡健康・長寿学術フォーラム
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] がん予防食品因子イソチオシアネート結合タンパク質の網羅的探索法2012
- Author(s)
  三好規之、米持巧、伴野勧、中村宜督、大島寛史
- Organizer
  第85回日本生化学会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 肥満モデルマウスKK-Ayにおける山薬およびジオスゲニンの大腸発がん予防分子機構解析2012
- Author(s)
  三好規之、長澤友樹、田中卓二、若林敬二、大島寛史
- Organizer
  がん予防学会2012
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Dehydrogenase/reductase member 2 (DHRS2)におけるアセトアルデヒド修飾はMdm2との結合を減少させる2012
- Author(s)
  山田雄司、三好規之、大島寛史
- Organizer
  第71回日本癌学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] オゾン酸化コレステロール : 生成機構、生理活性および生活習慣病発症における役割2012
- Author(s)
  大島寛史、伴野勧、頼盈伶、三好規之
- Organizer
  第65回日本酸化ストレス学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] ヒトがん細胞におけるイソチオシアネート結合分子の網羅的解析2012
- Author(s)
  米持巧、中村宜督、大島寛史、三好規之
- Organizer
  第17回日本フードファクター学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 糖尿病モデルラット肝におけるDNA付加体の網羅的解析2012
- Author(s)
  三好規之、松田知成、大島寛史
- Organizer
  第71回日本癌学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 飲酒およびアセトアルデヒド曝露のバイオマーカーとしてのタンパク質中Nε-エチルリジンの有用性2012
- Author(s)
  Ryota Mabuchi, Noriyuki Miyoshi, Akira Yokoyama, Yoshihide Suwa, Kiyonari Kuriki, Toshinao Goda, Takashi Amagai, Hiroshi Ohshima
- Organizer
  日本環境変異原学会第41回大会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] LC-ESI-MS/MSを用いた脂質過酸化物由来アルデヒド化合物の網羅的解析法の開発2012
- Author(s)
  伴野勧、村田晴美、大畑美幸、三好規之、大島寛史
- Organizer
  第85回日本生化学会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] がん予防食品因子イソチオシアネート結合タンパク質の探索2012
- Author(s)
  三好規之、米持巧、中村宜督、大島寛史
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 日本のヤマイモ類及びその植物ステロイド成分によるマウス大腸発がんの予防2012
- Author(s)
  Hiroshi Ohshima, Tomoki Nagasawa, Natsuko Asai, Noriyuki Miyoshi, Keiji Wakabayashi, Takuji Tanaka
- Organizer
  The 1st International Conference on Pharma-Food
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] LC-MS/MSを用いたSIRT1活性測定法の開発2012
- Author(s)
  富岡三貴、伴野勧、三好規之、大島寛史
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] ジオスゲニンおよび山薬による食後高トリグリセライド血症の抑制効果2012
- Author(s)
  平田隼、三好規之、新井英一、大島寛史
- Organizer
  第17回日本フードファクター学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Dehydrogenase/reductase member 2 のアセトアルデヒド修飾はMdm2結合活性を低下させる2012
- Author(s)
  山田雄司、三好規之、伴野勧、大島寛史
- Organizer
  第85回日本生化学会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 大腸がんHCT116細胞におけるがん予防成分イソチオシアネートの標的タンパク質探索2011
- Author(s)
  米持巧、三好規之、中村宜督、大島寛史
- Organizer
  日本農芸化学会2011
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 食品成分イソチオシアネートの標的タンパク質探索法の開発2011
- Author(s)
  三好規之、米持巧、中村宜督、大島寛史
- Organizer
  日本農芸化学会2011
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] ヤムイモ(山薬)およびその有効成分ジオスゲニンによる大腸発がんの化学予防2011
- Author(s)
  三好規之、長澤友樹、浅井奈津子、田中卓二、若林敬二、野口博司、大島寛史
- Organizer
  第4回食品薬学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Analysis of N^e-ethyllysine in human plasma proteins as a biomarker for exposure to acetaldehyde and alcohol2011
- Author(s)
  馬渕良太、三好規之、横山顕、諏訪芳秀、栗木清典、合田敏尚、雨谷敬史、大島寛史
- Organizer
  日本環境変異原学会第40回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Development of a comprehensive analytical method for identification of isothiocyanates-binding proteins2011
- Author(s)
  Miyoshi N, Yonemochi T, Nakamura Y, Ohshima H
- Organizer
  2011 International conference on Food Factors
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] エステル型secosterol類のヒトLDLコレステロールからの検出と細胞毒性2011
- Author(s)
  伴野勧、岩崎希、三好規之、大島寛史
- Organizer
  第75回日本生化学会中部支部例会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Identification of target proteins responsible for chemopreventive activities of isothiocyanates in human colon cancer HCT116 cells2011
- Author(s)
  Yonemochi T, Nakamura Y, Ohshima H, Miyoshi N
- Organizer
  2011 International conference on Food Factors
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 肥満マウスKK-A^yにおける山薬およびジオスゲニンのaberrant crypt foci形成抑制2011
- Author(s)
  長澤友樹、三好規之、田中卓二、武藤倫弘、若林敬二、大島寛史
- Organizer
  第18回日本がん予防学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Secosterol型コレステロール酸化物の生体内生成機構と生理活性2011
- Author(s)
  三好規之、伴野勧、瀬盈伶、東達也、荒谷康昭、大島寛史
- Organizer
  第64回日本酸化ストレス学会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] イソチオシアネート結合タンパク質の網羅的探索法の開発2011
- Author(s)
  米持巧、中村宜督、加藤陽二、大島寛史、三好規之
- Organizer
  第20回フードサイエンスフォーラム
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 新規糖化反応後期生成物:N^W-(carboxyethyl) arginine (CEA)の免疫化学的な血中濃度の測定2011
- Author(s)
  永井竜児、島崎智子、三好規之、大島寛史、永井美芽
- Organizer
  84回日本生化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Anti-obesity effects of Chinese yam sanyaku and its constituent diosgenin in type II diabetic KK-A^y mice fed a high-fat diet2011
- Author(s)
  Asai N, Ohata M, Miyoshi N, Kanazawa H, Ohshima H
- Organizer
  2011 International conference on Food Factors
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 糖尿病モデルマウス腎臓での糖化反応と血管拡張因子NOの産生阻害2011
- Author(s)
  三好規之、大畑美幸、浅井奈津子、頼盈伶、金澤寛明、大島寛史
- Organizer
  第11回日本NO学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Chemopreventive effects of freeze-dried yams and its constituent dios genin on mouse colon carcinogenesis2011
- Author(s)
  Miyoshi N, Nagasawa T, Tanaka T, Wakabayashi K, Noguchi H, Ohshima H
- Organizer
  4th International Conference of Health and Longevity Sciences
- Place of Presentation
  静岡
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] ヒト肝がん細胞HepG2におけるHep27タンパク質のアセトアルデヒド修飾2011
- Author(s)
  山田雄司、栗田亜也、馬渕良太、伴野勧、三好規之、大島寛史
- Organizer
  84回日本生化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] ヤムイモ成分による大腸がんの化学予防2010
- Author(s)
  長澤友樹、馬渕良太、三好規之、田中卓二、大島寛史
- Organizer
  第17回日本がん予防学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] ミエロペルオキシダーゼによるsecosterol型コレステロール酸化物の生成2010
- Author(s)
  伴野勧, 三好規之, 荒谷康昭, 大島寛史
- Organizer
  第63回日本酸化ストレス学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 乳がんのリスクマーカーとしての尿中のカテコールエストロゲン-DNA付加体の分析2010
- Author(s)
  戸井口恭子、三好規之、東達也、糠谷東雄、高橋智、若林敬二、大島寛史
- Organizer
  第39回日本環境変異原学会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] ヤム類およびヤムイモ成分ジオスゲニンはAOM/DSS誘発マウス大腸発がんを抑制する2010
- Author(s)
  三好規之、長澤友樹、安井由美子、田中卓二、大島寛史
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] ミエロペルオキシダーゼによるsecosterol型コレステロール酸化物の生成2010
- Author(s)
  伴野勧、三好規之、荒谷康昭、大島寛史
- Organizer
  第63回日本酸化ストレス学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Secosterol-A, an oxidized cholesterol metabolite, may contribute to atherosclerosis and neurodegenerative diseases through inhibition of eNOS and nNOS2010
- Author(s)
  Lai Y-L, Tomono S, Miyoshi N, Ohshima H.
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] アセトアルデヒドを消去する食品及び食品成分の探索2010
- Author(s)
  鈴木啓子、三好規之、糠谷東雄、大島寛史
- Organizer
  第54回日本食品科学工学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] エステル型コレステロールのオゾン酸化物のHL-60細胞に対する細胞毒性作用2010
- Author(s)
  岩崎希, 三好規之, 伴野勧, 大島寛史
- Organizer
  第63回日本酸化ストレス学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Secosterol型コレステロール酸化物のLC-MS/MSによる高感度検出法の開発2010
- Author(s)
  三好規之、伊藤萌、伴野勧、東達也、大島寛史
- Organizer
  第63回日本酸化ストレス学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] エステル型コレステロールのオゾン酸化物のHL-60細胞に対する細胞毒性作用2010
- Author(s)
  岩崎希、三好規之、伴野勧、大島寛史
- Organizer
  第63回日本酸化ストレス学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Alteration in activity and expression of renal NOS and dimethylarginine dimethylaminohydrolase in type 2 diabetic rats2010
- Author(s)
  Ohata M, Lai Y-L, Aoyama S, Miyoshi N, Fujiwara A, Kanazawa H, Ohshima H.
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] シクロデキストリン包接によるトコトリエノールのバイオアベイラビリティ向上効果2010
- Author(s)
  矢野友啓、若尾陽平、三好規之、大島寛史
- Organizer
  第62回日本ビタミン学会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Secosterol-A, an oxidized cholesterol metabolite, may contribute toatherosclerosis and neurodegenerative diseases through inhibition of eNOS and nNOS2010
- Author(s)
  Ying-Ling Lai, Susumu Tomono, Noriyuki Miyoshi, Hiroshi Ohshima
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Secosterol型コレステロール酸化物のLC-MS/MSによる高感度検出法の開発2010
- Author(s)
  三好規之, 伊藤萌, 伴野勧, 東達也, 大島寛史
- Organizer
  第63回日本酸化ストレス学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] アセトアルデヒド曝露マーカーとしてのN^ε-ethyllysine を認識するモノクローナル抗体の作製とその応用2009
- Author(s)
  栗田亜也, 馬渕良太, 鈴木あずさ, 三好規之, 大島寛史
- Organizer
  日本環境変異原学会第38回大会
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] ミエロペルオキシターゼによるオゾン酸化コレステロールの生成機構2009
- Author(s)
  伴野勧、三好規之、佐藤和昭、大場好弘、荒谷康昭、大島寛史
- Organizer
  第62回日本酸化ストレス学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] The myeloperoxidase-H_2O_2-chloride system produces cholesterol ozonolysis products via an ozone-free mechanism2009
- Author(s)
  Tomono S, Miyoshi N, Shiokawa H, Ito M, Aratani Y, Ohshima H
- Organizer
  SFRR-Europ Meeting 2009
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] オゾン酸化コレステロールによるeNOS及びnNOS活性の阻害2009
- Author(s)
  頼盈伶, 伴野勧, 三好規之, 大島寛史
- Organizer
  第9回日本NO学会学術集会
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Qunatitative analysis of N^ε-ehyllysine in human plasma proteins by NCI-GC/MS as a biomarker for acetaldehyde exposure2009
- Author(s)
  Mabuchi R, Kurita A, Miyoshi N, Kan T, Amagai T, Ohshima H
- Organizer
  10th International Conference on Environmental Mutagens(ICEM)
- Place of Presentation
  Firenze, Italy
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] ミエロペルオキシターゼによるオゾン酸化コレステロールの生成機構2009
- Author(s)
  伴野勧, 三好規之, 佐藤和昭, 大場好弘, 荒谷康昭, 大島寛史
- Organizer
  第62回日本酸化ストレス学会学術集会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] アセトアルデヒド曝露マーカーとしての核酸付加体の分析2009
- Author(s)
  鈴木あずさ, 馬渕良太, 伴野勧, 栗田亜也, 三好規之, 大島寛史
- Organizer
  日本環境変異原学会第38回大会
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] アセトアルデヒド曝露マーカーとしてのヒト血漿タンパク質中のN^ε-エチルリジンのNCI-GC/MSによる分析2009
- Author(s)
  馬渕良太, 栗田亜也, 鈴木あずさ, 三好規之, 菅敏幸, 雨谷敬史, 大島寛史
- Organizer
  日本環境変異原学会第38回大会
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] The myeloperoxidase-H_2O_2-chloride system produces cholesterol ozonolysis products via an ozone free mechanism2009
- Author(s)
  Susumu Tomono, Noriyuki, Miyoshi, Hidemi, Shiokawa, Megumi, Ito, Yasuaki, Aratani, Hiroshi, Ohshima
- Organizer
  SFRR Europe meeting Rome 2009
- Place of Presentation
  Roma, Italy
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 「ヤムイモ」(山薬)およびその含有成分ジオスゲニンによる大腸がん発がんの予防2009
- Author(s)
  三好規之, 安井由美子, 若尾陽平, 鈴木あずさ, 田中卓二, 大島寛史
- Organizer
  第16回日本がん予防学会(がん予防大会2009)
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 2型糖尿病モデルラットにおけるDDAH活性変動と血中インスリン濃度の関連2009
- Author(s)
  三好規之, 青山沙絵, 頼盈伶, 大塚菜未, 塩川秀美, 大島寛史
- Organizer
  第9回日本NO学会学術集会
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Alterations of activities of enzymes involving in the regulation of nitricoxide biosynthesis in the kidney of OLETF rats, a model for type 2 diabetes mellitus2009
- Author(s)
  Lai Y-L, Aoyama S, Otsuka N, Shiokawa H, Miyoshi N, Ohshima H
- Organizer
  SFRR-Europ Meeting 2009
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] OLETFラット2型糖尿病発症過程におけるNO産生に関わる酵素活性の変動2009
- Author(s)
  頼盈伶, 青山沙絵, 大塚菜未, 塩川秀美, 三好規之, 大島寛史
- Organizer
  第62回日本酸化ストレス学会学術集会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 内因性NOS阻害剤 asymmetric NG, NG-dimethyl-L-arginine(ADMA)に構造的類似する糖化最終産物AGEsのNO産生制御に関わる酵素活性に及ぼす影響2009
- Author(s)
  頼盈伶, 青山沙絵, 永井竜児, 三好規之, 大島寛史
- Organizer
  第9回日本NO学会学術集会
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] オゾン酸化コレステロールによるeNOS及びnNOS活性の阻害2009
- Author(s)
  瀬盈伶、伴野勧、三好規之、大島寛史
- Organizer
  第9回日本NO学会学術集会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] シクロデキストリン包接化によるトコトリエノール生理活性増強効果検証2009
- Author(s)
  若尾陽平, 三好規之, 矢野友啓, 大島寛史
- Organizer
  第19回フードサィエンスフォーラム
- Place of Presentation
  静岡県伊東市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] シクロデキストリン包接化によるトコトリエノール生理活性増強効果2009
- Author(s)
  若尾陽平, 三好規之, 矢野友啓, 大島寛史
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 環境変異原研究におけるバイオマーカー2009
- Author(s)
  大島寛史
- Organizer
  日本環境変異原学会第38回大会
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Cholesterol ozonolysis products as a possible biomarker for metabolic syndrome.2008
- Author(s)
  Tomono S., Iwabuchi T., Yasue Y., Niizuma S., Miyoshi M., Ohshima H.
- Organizer
  International symposium on Biomarkers of Oxidative Stress in Health and Diseases
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] ozonolysis products as a possible biomarker for metabolic syndrome2008
- Author(s)
  Tomono, S., Iwabuchi, T., Yasue, Y., Niizuma, S., Miyoshi, M., Ohshima, H
- Organizer
  International symposium on Biomarkers of Oxidative Stress in Health and Diseases
- Place of Presentation
  (Osaka, Japan), Jan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] Cholesterol ozonolysis products as a possible biomarker for metabolic syndrome2008
- Author(s)
  Tomono, S., Iwabuchi, T., Yasue, Y., Niizuma, S., Miyoshi, M., Ohshima, H
- Organizer
  International symposium on Biomarkers of Oxidative Stress in Health and Diseases
- Place of Presentation
  Osaka,Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] Molecular mechanism of cell damage by ozonolysis of cholesterol in HL-60 cells2007
- Author(s)
  Tomono, S., Niiduma, S., Iwabuchi, T., Yasue, Y., Miyoshi, N., Ohshima, H
- Organizer
  Biochemistry and Molecular Biology 2007
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] DNA and protein damage induced by inflammatory oxidnts: role in carcinogenesis2007
- Author(s)
  Ohshima H.
- Organizer
  The 2007 International Symposium on Advanced Bioscience
- Place of Presentation
  Cheongju, Korea
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] Nitrative DNA damage in inflammation and carcinogenesis2007
- Author(s)
  Ohshima, H., Sawa, T., Tazawa, H., Kawanishi, S
- Organizer
  ICoFF2007-International Conference on Food Factors for Health Promotion
- Place of Presentation
  Kyoto,Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] Helicobacter pylori Infection,Oxidative and Nitrative Stress and Stomach Cencer2007
- Author(s)
  Ohshima H., Sawa, T.Tatemichi, M., Bancel, B., Pignatelli, B
- Organizer
  The Keystone Symposium on 'Frontiers in Gastrointestinal Cancer:Molecular Genetics, Inflammation, Early Detection and Therapy'
- Place of Presentation
  Beijing,China
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] Molecular mechanism of selective cytotoxicity by chemopreventive isothiocyanates.2007
- Author(s)
  Miyoshi N., Nakamura Y., Ohshima H.
- Organizer
  International Conference on Food Factors for Health Promotion
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2007-12-27
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] DNA and protein damage induced by inflammatory oxidnts:role in carcinogenesis2007
- Author(s)
  Ohshima, H., Sawa, T., Tazawa, H
- Organizer
  The 2007 International Symposium on Advanced Bioscience
- Place of Presentation
  Cheongju,Korea
- Year and Date
  2007-06-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] オゾン酸化コレステロールによるHレ60細胞の細胞傷害分子機構2007
- Author(s)
  伴野勧, 新妻聖子, 岩渕智恵, 安江祐佳里, 三好規之, 大島寛史
- Organizer
  第80回日本生化学会大会(Biochemistry and Molecular Biology2007)
- Place of Presentation
  横浜市(パシフィコ横浜)
- Year and Date
  2007-12-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] The role of nitrative DNA damage in inflammation-associated carcinogenesis2007
- Author(s)
  Ohshima H.
- Organizer
  The 1st International Conference on Nitric Oxide(NO)and Cancer
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] Nitrative DNA damage in inflammation and carcinogenesis2007
- Author(s)
  Ohshima, H., Sawa, T., Tazawa, H., Kawanishi, S
- Organizer
  Invited speaker at the ICoF F2007
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] Helicobacter pylori Infection, Oxidative and Nitrative Stress and Stomach Cancer2007
- Author(s)
  Ohshima, H., Sawa, T., Tatemichi, M., Bancel, B., Pignatelli, B
- Organizer
  Invited speaker at the Keystone Symposium on `Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy'
- Place of Presentation
  Beijing, China
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] Nitrative DNA damage in inflammation and carcinogenesis2007
- Author(s)
  Ohshima H.
- Organizer
  ICoFF2007・International Conference on Food Factors for Health Promotion
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] Molecular mechanism of selective cytotoxicity by chemopreventive isothiocyanates2007
- Author(s)
  Miyoshi, N., Nakamura, Y., Ohshima, H
- Organizer
  International Conference on Food Factors for Health Promotion
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] Helicobacter pylori Infection, Oxidative and Nitrative Stress and Stomach Cancer.2007
- Author(s)
  Ohshima H.
- Organizer
  The Keystone Symposium on 'Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy'
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] The role of nitrative DNA damage in inflammation-associated carcinogenesis2007
- Author(s)
  Ohshima, H., Sawa, T., Tazawa, H., Kawanishi, S
- Organizer
  Invited speaker at the 1st International Conference on Nitric Oxide (NO) and Cancer
- Place of Presentation
  Paris, France
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] オゾン酸化コレステロールによるHL-60細胞の細胞傷害分子機構2007
- Author(s)
  伴野勧, 新妻聖子, 岩渕智恵, 安江祐佳里, 三好規之, 大島寛史
- Organizer
  第80回日本生化学会大会(Biochemistry and Molecular Biology 2007)
- Place of Presentation
  横浜市(パシフィコ横浜)
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] The role of nitrative DNA damage in inflammation-associated2007
- Author(s)
  Ohshima, H., Sawa, T., Tazawa, H., Kawanishi, S
- Organizer
  The 1st International Conference on Nitric Oxide(NO)and Cancer
- Place of Presentation
  Paris,France
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] DNA and protein damage induced by inflammatory oxidnts: role in carcinogenesis2007
- Author(s)
  Ohshima, H., Sawa, T., Tazawa, H
- Organizer
  Invited speaker at the 2007 International Symposium on Advanced Bioscience
- Place of Presentation
  Cheongju, Korea
- Year and Date
  2007-06-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18509001
[Presentation] 多層ナノチューブ肺内投与によって生じる活性カルボニル化合物の網羅的解析
- Author(s)
  伴野勧、三好規之、徐結荀、津田洋幸、大島寛史
- Organizer
  第67回日本酸化ストレス学会
- Place of Presentation
  同志社大学、京都市
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24300257

1. NUKAYA Haruo (00094342)

# of Collaborated Projects: 2 results

# of Collaborated Products: 139 results
2. MIYOSHI Noriyuki (70438191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. GODA Toshinao (70195923)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. HIGASHI Tatsuya (90272963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. TOMONO Susumu (60554011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
6. MASUDA Shuichi (40336657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中村宜督

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHSHIMA Hiroshi 大島 寛史

Research Projects

Research Products

Co-Researchers

Ozone-oxidized cholesterols as biomarkers for metabolic syndrome and life-style related diseasesPrincipal Investigator

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Elucidations of the mechanisms for the formation of cholesterol-ozonolysis products in inflamed tissues, their biological activities and involvement in disease developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of inflammation-mediated oxidized cholesterols as novel biomarkers of the metabolic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 酸化ストレスの医学2014

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[Book] CANCER AND INFLAMMATION MECHANISMS Chemical, Biological and Clibical Asdpects2014

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[Book] 基礎生化学-健康・疾病とのつながり-2013

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[Book] 抗ストレス食品の開発と展望II2012

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[Book] Inflammation Induced Carcinogenesis and Chemoprevention. Chemoprevention of Cancer and DNA Damage by Dietary Factors2009

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[Book] Inflammation Induced Carcinogenesis and Chemoprevention2008

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Description

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[Book] がん予防『酸化ストレスの医学』2008

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Description

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[Book] Inflammation Induced Carcinogenesis and Chemoprevention.2008

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[Book] がん予防『酸化ストレスの医学』2008

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[Book] 三好規之ら、がん予防と酸化ストレス、酸化ストレスの医学2008

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[Journal Article] Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitric-oxide-mediated cyclooxygenase 2 activation2015

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[Journal Article] Comprehensive analysis of the lipophilic reactive carbonyls present in biological specimens by LC/ESI-MS/MS2015

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[Journal Article] Implications of cholesterol autoxidation products in the pathogenesis of inflammatory diseases2014

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DOI

OHSHIMA Hiroshi 大島寛史

[Book] CANCER AND INFLAMMATION MECHANISMS　Chemical, Biological and Clibical Asdpects2014