SHIMIZU Tetsuya 清水哲哉

Researcher Number	80435651
Affiliation (based on the past Project Information) *help	2008: 独立法人理化学研究所, 研究技術開発室 2007 – 2008: 独立法人理化学研究所, 研究技術開発室, 研究員 2006 – 2007: 独立行政法人理化学研究所, 研究技術開発室, 協力研究員
Review Section/Research Field	Principal Investigator Structural biochemistry Except Principal Investigator Bioproduction chemistry/Bioorganic chemistry
Keywords	Principal Investigator X線結晶解析 / タンパク質と酵素 / 構造生物学 / X線結晶構造解析 Except Principal Investigator NMR / 動力学計算 / 熱化学実験 / 安定誘導体の合成 / 多糖 / 酵素反応遷移状態配座 … More / エンド型グリコシダーゼ / 化学合成 / 遷移状態アナログ / 硫黄置換誘導体 / 基質アナログ / エンドポリガラクツロナーゼ / セルラーゼ / エンドグリコシダーゼ / 複合体形成 / 基質ミミック / 反応機構 / endo型グリコシダーゼ Less

A reaction mechanism elucidation study based on many sugar-endo Type glycosidase complex analysi
- Principal Investigator
  
  HASHIMOTO Masaru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Hirosaki University
エンドポリガラクツロナーゼの超原子分解能結晶を用いた酵素反応の直接観察Principal Investigator
- Principal Investigator
  
  清水哲哉
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research

All 2009 2008 2007

All Journal Article Presentation

[Journal Article] Expression, purify- cation and analyses of glycosylation and disulfide bonds of Stereum purpureu endopolygalacturonase I in Pichia pastoris2009
- Author(s)
  S. Ogawa, T. Shimizu, H. Ohki, T. Araya, T. Okuno, K. Miyairi
- Journal Title
  
  Protein Expression and Purification 65
  
  Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Expression, purification and analyses of glycosylation and disulfide bonds of Stereum purpureum endopolygalacturonase I in Pichia pastoris2009
- Author(s)
  S. Ogawa, T. Shimizu, H. Ohki, T. Araya, T. Okuno, K. Mivairi
- Journal Title
  
  Protein Expression and Purification 65
  
  Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Synthesis of D-trigalacturonic acid methylglycoside2008
- Author(s)
  Yamamoto, K., Sato, Y., Ishimori, A., Miyairi, K., Okuno, T., Nemoto, N., Shimizu, H., Kidokoro, S., Hashimoto, M
- Journal Title
  
  Biosci. Biotech. Biochem 72(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Synthesis of D-trigalacturonic acid methylglycoside2008
- Author(s)
  Yamamoto, K., Sato, Y., Ishimori, A., Miyairi, K., Okuno, T., Nemoto, N., Shimizu, H.,Kidnknro. S., Hashimoto. M.
- Journal Title
  
  Biosci. Biotech. Biochem 71
  
  Pages: 1230-1235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] New glycosylation method Part III : Study of microwave effects at low temperatures to control reaction pathways and reduce byproducts2008
- Author(s)
  H. Shimizu, Y. Yoshimura, H. Hinou ; S. -I. Nishimura
- Journal Title
  
  Tetrahedron 64
  
  Pages: 10091-10096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Chemical and enzymatic synthesis of neoglycolipids in the presence of cyclodextrins2008
- Author(s)
  Nagashima I.,Shimizu H., et.al.
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 3413-3418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] 結合の角度から分子の立体構造を決める、液晶NMR法2008
- Author(s)
  清水弘樹
- Journal Title
  
  化学と生物 46
  
  Pages: 648-652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Chemical and enzymatic synthesis of neoglycolipids in the presence of cvclodextrins2008
- Author(s)
  I. Nagashima, H. Shimizu, T. Matsushita, S. -I. Nishimura
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 3413-3418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Synthesis of D-trigalacturonic acid methylglycoside2008
- Author(s)
  Yamamoto, K., Sato, Y., Ishimori, A., Miyairi, K., Okuno, T., Nemoto, N.,Shimizu, H., Kidokoro, S., Hashimoto, M.
- Journal Title
  
  Biosci. Biotech. Biochem 71
  
  Pages: 1230-1235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Expression, purification, and analyses of glycosylation and disulfide bonds of Stereum purpreum endopolygalacturonase I in Pichia pastoris2008
- Author(s)
  Ogawa, S., Shimizu, T., Ohki, H., Araya, T., Okuno, T., Miyairi, K.
- Journal Title
  
  Protein Expression and Purification 65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] New glycosylation method Part III : Study of microwave effects at low temperatures to control reaction pathways and reduce byproductsq2008
- Author(s)
  H. Shimizu, et.al.
- Journal Title
  
  Tetrahedron 64
  
  Pages: 10091-10096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 難溶性糖脂質に対する糖転移酵素反応のシクロデキストリン効果Part22009
- Author(s)
  清水弘樹
- Organizer
  日本農芸化学会2009年度
- Place of Presentation
  福岡
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] ペプチド固相反応適応合成および不凍活性2009
- Author(s)
  清水弘樹, 他
- Organizer
  第43回高分子学会北海道支部研究発表会
- Place of Presentation
  札幌
- Year and Date
  2009-02-03
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] マイクロ波固相合成装置の開発と、ペプチド合成研究2009
- Author(s)
  清水弘樹
- Organizer
  日本農芸化学会2009年度
- Place of Presentation
  福岡
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] リンゴ銀葉病菌由来エンドポリガラクツロナーゼIのC末端領域は自己の活性を阻害する2009
- Author(s)
  小川俊、宇藤憲則、大木肇、清水哲哉、奥野、宮入一夫
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] リンゴ銀葉病菌由来エンドポリガラクツロナーゼ1のC末端領域は自己の活性を阻害する2009
- Author(s)
  小川俊、宇藤憲則、大木肇、清水哲哉、奥野智旦、宮入一夫
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] ペプチド固相反応適応型マイクロ波合成反応装置の開発と利用研究2009
- Author(s)
  清水弘樹、長島生、松下隆彦、西村紳一郎、為野強士、秋元正寿
- Organizer
  第43回高分子学会北海道支部研究発表会
- Place of Presentation
  札幌
- Year and Date
  2009-02-03
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 環状不凍糖タンパク質の合成および不凍活性2009
- Author(s)
  清水弘樹, 他
- Organizer
  第43回高分子学会北海道支部研究発表会
- Place of Presentation
  札幌
- Year and Date
  2009-02-03
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Shutter-less continuous rotation data collection from protein crystals with the X-ray CMOS detector2008
- Author(s)
  Kazuya Hasegawa, Kunio hirata, Tetsuya Shimizu, Takashi Kumasaka, and Masaki Yamamoto
- Organizer
  第21回国際結晶学会議
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Practical study of nonthermal microwave effects applying to oligosaccharide syntheses2008
- Author(s)
  H. Shimizu, T. Matsushita, S. -I. Nishimura
- Organizer
  GCMEA 2008 MAJIC : 1st Global Conference on Microwave Energy Applications
- Place of Presentation
  Otsu Shiga, Japan
- Year and Date
  2008-08-06
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] リンゴ銀葉病菌由来Endopoly alacturonaseIの欠失C末端44残基の機能解析2008
- Author(s)
  小川俊, 大木肇, 清水哲哉, 奥野智旦, 宮入一夫
- Organizer
  日本応用糖質科学会2008年度大会
- Place of Presentation
  沖縄
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Cyclodextrin effects for synthesis of neoglycolipids by glycosyltransferases2008
- Author(s)
  H. Shimizu, I. Nagashima, T. Matsushita, S. -I. Nishimura
- Organizer
  24th International Carbohydrate Symposium
- Place of Presentation
  Oslo, Norway
- Year and Date
  2008-07-27
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Manipulating Proteinmicrocrystal with optical tweezersbased on lensed fiber probes2008
- Author(s)
  Takaaki Hikima, Tetsuya Shimizu and Masaki Yamamoto
- Organizer
  第21回国際結晶学会議
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Ultra-high resolution structure of endopolygalacturonase determined by X-rayand neutron diffraction2008
- Author(s)
  Tetsuya Shimizu, Toru Nakatsu, Nobutaka Shimizu, Mamoru Sato, Kauo Kurihara, Kazuo Miyairi, Toshikatsu Okuno, Nobuo Niimura, Hiroaki Kato
- Organizer
  第21回国際結晶学会議
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 機能性食品開発や創薬を指向した糖鎖の応用-マイクロ波を利用した効率的合成法の開発を背景に-2008
- Author(s)
  清水弘樹, 他
- Organizer
  HiNTセミナー20085
- Place of Presentation
  札幌
- Year and Date
  2008-08-26
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] マイクロ波を活用した糖鎖・糖ペプチド合成研究2008
- Author(s)
  清水弘樹, 他
- Organizer
  第50回天然有機化合物討論会
- Place of Presentation
  福岡
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Ultra-high resolution structure of endolygalaturonase determined by X-ray and neutron diffraction2008
- Author(s)
  清水哲哉
- Organizer
  第21回国際結晶学会議
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Remodeling of Mouse Notch-1 Glycopeptide : Synthesis and Strue tural Characterization of Glycosylated Epidermar Growth Factor-Like Reneats 122008
- Author(s)
  K. H. Shimizu, N. Fujitani, H. Shimizu, S. -I. Nishimura
- Organizer
  24th International Carbohydrate Symposium
- Place of Presentation
  Oslo, Norway
- Year and Date
  2008-07-31
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 難溶性擬似糖脂質の水溶液中での酵素反応を可能とするシクロデキストリンの効果2008
- Author(s)
  清水弘樹、長島生、松下隆彦、西村紳一郎
- Organizer
  第28回日本糖質学会年会
- Place of Presentation
  つくば
- Year and Date
  2008-08-19
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] リンゴ銀葉病菌由来Endopolygalacturonase Iの欠失C末端44残基の機能解析2008
- Author(s)
  小川俊, 大木肇, 清水哲哉, 奥野智旦, 宮入一夫
- Organizer
  日本応用糖質科学会2008年度大会
- Place of Presentation
  沖縄
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] ペプチド固相合成に特化させたマイクロ波利用合成装置の開発とその利用研究2008
- Author(s)
  清水弘樹, 他
- Organizer
  平成20年度第二回合同学術講演会
- Place of Presentation
  帯広
- Year and Date
  2008-11-09
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 機能性食品開発や創薬を指向した糖鎖の応用-マイクロ波を利用した効率的合成法の開発を背景に-2008
- Author(s)
  清水弘樹
- Organizer
  HiNTセミナー2008-5
- Place of Presentation
  札幌
- Year and Date
  2008-08-26
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] X線結晶構造解析によるリンゴ銀葉病菌由来エンドポリガラクツロナーゼIの基質認識機構解明2007
- Author(s)
  清水哲哉
- Organizer
  日本結晶学会2007年年会
- Place of Presentation
  東京
- Year and Date
  2007-12-02
- Data Source
  KAKENHI-PROJECT-18870029

1. HASHIMOTO Masaru (40212138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. MIYAIRI Kazuo (10003526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. SAITO Minoru (60196011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KIDOKORO Syunichi (80195320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHIMIZU Hiroki (30344716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 32 results
6. 城戸俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SHIMIZU Tetsuya 清水 哲哉

Research Projects

Research Products

Co-Researchers

A reaction mechanism elucidation study based on many sugar-endo Type glycosidase complex analysi

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エンドポリガラクツロナーゼの超原子分解能結晶を用いた酵素反応の直接観察Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Expression, purify- cation and analyses of glycosylation and disulfide bonds of Stereum purpureu endopolygalacturonase I in Pichia pastoris2009

Author(s)

Journal Title

Data Source

[Journal Article] Expression, purification and analyses of glycosylation and disulfide bonds of Stereum purpureum endopolygalacturonase I in Pichia pastoris2009

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of D-trigalacturonic acid methylglycoside2008

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of D-trigalacturonic acid methylglycoside2008

Author(s)

Journal Title

Data Source

[Journal Article] New glycosylation method Part III : Study of microwave effects at low temperatures to control reaction pathways and reduce byproducts2008

Author(s)

Journal Title

Data Source

[Journal Article] Chemical and enzymatic synthesis of neoglycolipids in the presence of cyclodextrins2008

Author(s)

Journal Title

Data Source

[Journal Article] 結合の角度から分子の立体構造を決める、液晶NMR法2008

Author(s)

Journal Title

Data Source

[Journal Article] Chemical and enzymatic synthesis of neoglycolipids in the presence of cvclodextrins2008

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of D-trigalacturonic acid methylglycoside2008

Author(s)

Journal Title

Data Source

[Journal Article] Expression, purification, and analyses of glycosylation and disulfide bonds of Stereum purpreum endopolygalacturonase I in Pichia pastoris2008

Author(s)

Journal Title

Data Source

[Journal Article] New glycosylation method Part III : Study of microwave effects at low temperatures to control reaction pathways and reduce byproductsq2008

Author(s)

Journal Title

Data Source

[Presentation] 難溶性糖脂質に対する糖転移酵素反応のシクロデキストリン効果Part22009

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ペプチド固相反応適応 合成および不凍活性2009

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] マイクロ波固相合成装置の開発と、ペプチド合成研究2009

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] リンゴ銀葉病菌由来エンドポリガラクツロナーゼIのC末端領域は自己の活性を阻害する2009

Author(s)

SHIMIZU Tetsuya 清水哲哉

[Presentation] ペプチド固相反応適応合成および不凍活性2009