Mukohara Toru 向原徹

… Alternative Names

MUKOHARA Toru 向原徹

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Researcher Number	80435718
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 東病院, 科長
Affiliation (based on the past Project Information) *help	2018 – 2024: 国立研究開発法人国立がん研究センター, 東病院, 科長 2017: 国立研究開発法人国立がん研究センター, その他部局等, 研究員 2016: 神戸大学, 医学部附属病院, 特命准教授 2015: 神戸大学, 医学部附属病院, 准教授 2013: 神戸大学, 医学部附属病院, 特命准教授 … More 2012 – 2013: 神戸大学, 医学部附属病院, 准教授 2009 – 2011: Kobe University, 医学部附属病院, 特命准教授 2008: Kobe University, 医学部・附属病院, 特命准教授 2007: 国立がんセンター, 研究員 2006 – 2007: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 機能診断開発部, 研究員 Less
Review Section/Research Field	Principal Investigator Applied pharmacology / Medical pharmacy / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 58060:Clinical nursing-related / Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 50:Oncology and related fields / Applied pharmacology
Keywords	Principal Investigator 個別化治療 / PI3K / 3D培養 / HER2 / 分子標的治療 / チロシンキナーゼ / 乳がん / 乳癌 / 体腔液 / CTC … More / 分子標的薬 / 循環細胞中がん細胞（CTC） / 循環血液中癌細胞 / 薬効試験 / 初代培養 / 脂肪幹細胞 / トラスツズマブ / PDX / 3次元培養 / キナーゼ阻害薬 / MET / 胃癌 / 胃がん / シグナル伝達 / PIK3CA / 癌 / IGF-IR … More Except Principal Investigator 乳がん / 自己管理 / 継続支援 / がん患者 / QOL / TROP2 / HER3 / HER2 / 脳転移 / 家族性乳がん・卵巣がん / 新規生殖細胞突然変異 / スプライシング異常 / 5’非翻訳領域に位置する新規BRCA2変異 / 家族性乳癌・卵巣癌症候群（HBOC） / 意義不明変異（VUS） / BRCA2 / 臨床薬理学 / プロテオーム / 乳癌 / パクリタキセル / プロテオーム解析 / 抗腫瘍効果 / 末梢神経毒性 / 化学療法 Less

A novel germline mutation in the non-coding region of BRCA2 is associated with hereditary breast cancer
- Principal Investigator
  
  Ohashi Akihiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan
乳がん脳転移症例におけるHER3等治療標的の探索
- Principal Investigator
  
  古川孝広
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Japanese Foundation for Cancer Research
  National Cancer Center Japan
Effectiveness and functioning of an online support program to help female cancer patients manage their health and illness
- Principal Investigator
  
  水野道代
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58060:Clinical nursing-related
- Research Institution
  University of Tsukuba
3D co-culture of breast cancer in malignant effusion and CTC with adipose stem cellsPrincipal Investigator
- Principal Investigator
  
  Mukohara Toru
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Development of ex-vivo sensitivity test for anti-cancer drugs using 3D primary culture and patient-derived xenograftPrincipal Investigator
- Principal Investigator
  
  Mukohara Toru
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  National Cancer Center Japan
  Kobe University
individualization of anti-kinase drugs for Asian cancers using genomic and proteomic analysisPrincipal Investigator
- Principal Investigator
  
  MUKOHARA Toru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kobe University
Establishment of the optimal administration method for anticancer agents by proteomics and metabolomics
- Principal Investigator
  
  MINAMI Hironobu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kobe University
Mechanism of PI3K activation and individualized anti-kinase therapy in gastric cancerPrincipal Investigator
- Principal Investigator
  
  MUKOHARA Toru
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kobe University
Comprehensive research for individualized use of anti-ErbB2 monoclonal antibodies in breast cancerPrincipal Investigator
- Principal Investigator
  
  MUKOHARA Toru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kobe University
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
プロテオーム解析を用いた乳がんに対する受容体型チロシンキナーゼ阻害薬治療の個別化Principal Investigator
- Principal Investigator
  
  向原徹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2022 2020 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Effectiveness of an online support program to help female cancer patients manage their health and illness: Protocol for a randomized controlled trial2022
- Author(s)
  Mizuno M, Chiba I, Mukohara T, Kondo M, Maruo K, Ohigashi T, Naruo M, Asano Y, Onishi T, Tanabe H, Muta R, Mishima S, Okano S, Yuda M, Hosono A, Ueda Y, Bando H, Itagaki H, Ferrans CE, Akimoto T
- Journal Title
  
  Contemp Clin Trials Commun
  
  Volume: 30 Pages: 101035-101035
- DOI
  10.1016/j.conctc.2022.101035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08190, KAKENHI-PROJECT-23K20344
[Journal Article] Impacts of clinicopathological factors on efficacy of trastuzumab deruxtecan in patients with HER2-positive metastatic breast cancer2022
- Author(s)
  Nakajima Hiromichi、Harano Kenichi、Nakai Tokiko、Kusuhara Shota、Nakao Takehiro、Funasaka Chikako、Kondoh Chihiro、Matsubara Nobuaki、Naito Yoichi、Hosono Ako、Mitsunaga Shuichi、Ishii Genichiro、Mukohara Toru
- Journal Title
  
  The Breast
  
  Volume: 61 Pages: 136-144
- DOI
  10.1016/j.breast.2022.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07342
[Journal Article] Hybrid double-spiral microfluidic chip for RBC-lysis-free enrichment of rare cells from whole blood2022
- Author(s)
  Shirai Kentaro、Guan Guofeng、Meihui Tan、Xiaoling Peng、Oka Yuma、Takahashi Yusuke、Bhagat Ali Asgar S.、Yanagida Masatoshi、Iwanaga Shigeki、Matsubara Nobuaki、Mukohara Toru、Yoshida Tomokazu
- Journal Title
  
  Lab on a Chip
  
  Volume: 22 Issue: 22 Pages: 4418-4429
- DOI
  10.1039/d2lc00713d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07342
[Journal Article] Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells2020
- Author(s)
  Fujimoto Yumi、Morita Tomoko Yamamori、Ohashi Akihiro、Haeno Hiroshi、Hakozaki Yumi、Fujii Masanori、Kashima Yukie、Kobayashi Susumu S.、Mukohara Toru
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 21762-21762
- DOI
  10.1038/s41598-020-78646-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07342, KAKENHI-PROJECT-19K23930, KAKENHI-PROJECT-19K23929, KAKENHI-PROJECT-16K21746
[Journal Article] 3D Culture Represents Apoptosis Induced by Trastuzumab Better than 2D Monolayer Culture2018
- Author(s)
  Tatara T, Mukohara T, Tanaka R, Shimono Y, Funakoshi Y, Imamura Y, Toyoda M, Kiyota N, Hirai M, Kakeji Y, Minami H.
- Journal Title
  
  Ａｎｔｉｃａｎｃｅｒ　Ｒｅｓ
  
  Volume: 38 Issue: 5 Pages: 2831-2839
- DOI
  10.21873/anticanres.12528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08588, KAKENHI-PROJECT-16H05415
[Journal Article] Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer2015
- Author(s)
  Imamura Y, Mukohara T, Shimono Y, Funakoshi Y, Chayahara N, Toyoda M, Kiyota N, Takao S, Kono S, Nakatsura T, Minami H
- Journal Title
  
  Oncol Rep
  
  Volume: 33 Issue: 4 Pages: 1837-1843
- DOI
  10.3892/or.2015.3767
- NAID
  120005758024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23501268, KAKENHI-PUBLICLY-25130707, KAKENHI-PROJECT-15K08588, KAKENHI-PROJECT-26460627, KAKENHI-PROJECT-15K14381
[Journal Article] Regulation of MET kinase inhibitor resistance by copy number of MET in gastric carcinoma cells2014
- Author(s)
  Funakoshi Y, Mukohara T, Ekyalongo RC, Tomioka H, Kataoka Y, Yohei Shimono, Chayahara N, Toyoda M, Kiyota N, Fujiwara Y, Minami H
- Journal Title
  
  Oncol Res
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590639
[Journal Article] Regulation of MET kinase inhibitor resistance by copy number of MET　in gastric carcinoma cells2014
- Author(s)
  Yohei Funakoshi, Toru Mukohara, Roudy Chiminch Ekyalongo, Hideo Tomioka, Yu Kataoka, Yohei Shimono, Naoko Chayahara, Masanori Toyoda, Naomi Kiyota, Yutaka Fujiwara, Hironobu Minami
- Journal Title
  
  Oncology Research
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590639
[Journal Article] Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line2013
- Author(s)
  Yohei Funakoshi, Toru Mukohara, Hideo Tomioka, Roudy Chiminch Ekyalongo, Yu Kataoka, Yumiko Inui, Yuriko Kawamori, Masanori Toyoda, Naomi Kiyota, Yutaka Fujiwara,Hironobu Minami
- Journal Title
  
  Investigational New Drugs
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590639
[Journal Article] Mechanisms of acquired resistance to insulin-like growth factor 1 receptor inhibitor in MCF-7 breast cancer cell line.2013
- Author(s)
  Ekylongo RC, Mukohara T, Kataoka Y, Kiyota N, Fujiwara Y, Minami H.
- Journal Title
  
  Invest New Drugs
  
  Volume: 31 Pages: 293-303
- Data Source
  KAKENHI-PROJECT-23590640
[Journal Article] Excessive MET signaling causes acquired resistance to and addiction to MET inhibitors in MKN45 gastric cancer cell line2013
- Author(s)
  Funakoshi Y, Mukohara T, Tomioka H, Ekyalongo RC, Kataoka Y, Inui Y, Kawamori Y, Toyoda M, Kiyota N, Fujiwara Y, Minami H
- Journal Title
  
  Investigational New Drugs
  
  Volume: 31 Pages: 1158-1168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590639
[Journal Article] Mechanisms of acquired resistance to insulin-like growth factor 1 receptor inhibitor in MCF-7 breast cancer cell line2013
- Author(s)
  Ekylongo RC, Mukohara T, Kataoka Y, Kiyota N, Fujiwara Y, Minami H
- Journal Title
  
  Invest New Drugs
  
  Volume: 31 Pages: 293-303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590640
[Journal Article] Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line2013
- Author(s)
  Funakoshi Y, Mukohara T, Tomioka H, Ekyalongo RC, Kataoka Y, Inui Y, Kawamori Y, Toyoda M, Kiyota N, Fujiwara Y, Minami H
- Journal Title
  
  Invest New Drugs
  
  Volume: 31 (5) Pages: 1158-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590640
[Journal Article] Inhibition of mTOR-S6K signal is necessary to enhance fluorouracil-induced apoptosis in HER2-amplified gastric cancer cells2012
- Author(s)
  Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H
- Journal Title
  
  Int J Oncol
  
  Volume: 41 Pages: 551-558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590639
[Journal Article] Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks2012
- Author(s)
  Kataoka Y, Mukohara T, Tomioka H, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, and Minami H
- Journal Title
  
  Invest New Drugs
  
  Volume: 30 Pages: 1352-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590639
[Journal Article] Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification2012
- Author(s)
  Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H
- Journal Title
  
  Int J Oncol
  
  Volume: 41 Pages: 551-558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590640
[Journal Article] Inhibition of mTOR-S6K signal is necessary to enhance fluorouracil-induced apoptosis in HER2-amplified gastric cancer cells2012
- Author(s)
  Hideo Tomioka, Toru Mukohara, Yu Kataoka, Roudy Chminch Ekyalongo, Yohei Funakoshi, Yasuo Imai, Naomi Kiyota, Yutaka Fujiwara, Hironobu Minami
- Journal Title
  
  International Journal of Oncology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590639
[Journal Article] Eribulin mesylate in patients with refractory cancers:a phase I study2012
- Author(s)
  Mukohara T, Nagai S, Mukai H, Namiki M, Minami H.
- Journal Title
  
  Invest New Drugs
  
  Volume: 30 (5) Pages: 1926-1933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590640
[Journal Article] Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks2012
- Author(s)
  Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, Minami H
- Journal Title
  
  Invest New Drugs
  
  Volume: 30 (4) Pages: 1352-1360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590640
[Journal Article] Foretinib (GSK1363089) inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks2011
- Author(s)
  Yu Kataoka, Toru Mukohara, Hideo Tomioka, Naomi Kiyota, Yutaka Fujiwara, Masakazu Yashiro, Kosei Hirakawa, Hironobu Minami
- Journal Title
  
  Investigational New Drugs
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590639
[Journal Article] Gain of function mutations of PIK3CA is associated with resistance to HER2-targeted agents in HER2-amplified breast cancer cell lines2009
- Author(s)
  Kataoka Y, Mukohara T, Shimada H, Saijo N, Hirai M, Minami H.
- Journal Title
  
  Ann Oncol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790145
[Journal Article] Association between gain-of function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell lines.2009
- Author(s)
  Kataoka Y, Mukohara T, et al
- Journal Title
  
  Annals of Oncology 21
  
  Pages: 255-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790522
[Presentation] Adipsin enhanced clonogenicity and proliferation of human breast cancer patient-derived xenograft cells.2018
- Author(s)
  Goto H, Shimono Y, Mukohara T, et al.
- Organizer
  American Association for Cancer Research 201８
- Data Source
  KAKENHI-PROJECT-15K08588
[Presentation] 3D culture may better represent trastuzumab resistance associated with PIK3CA mutation than 2D culture2017
- Author(s)
  Takashi Tatara, Toru Mukohara, Rina Tanaka, Yohei Shimono, Masanori Toyoda, Naomi Kiyota, Midori Hirai, Yoshihiro Kakeji, Hironobu Minami
- Organizer
  AACR annual meeting
- Place of Presentation
  Washington DC
- Year and Date
  2017-04-01
- Data Source
  KAKENHI-PROJECT-15K08588
[Presentation] 3D culture may better represent trastuzumab resistance associated with PIK3CA mutation than 2D culture2017
- Author(s)
  Tatara T, Mukohara T, Tanaka R, Shimono Y, Funakoshi Y, Imamura Y, Toyoda M, Kiyota N, Hirai M, Kakeji Y, Minami H.
- Organizer
  American Association for Cancer Research 2017
- Data Source
  KAKENHI-PROJECT-15K08588
[Presentation] Comparison of 2D- and 3D-cultures in in vitro evaluation of trastuzumab in HER2-overexpressing breast cancer cell lines2016
- Author(s)
  Toru Mukohara, Rina Tanaka, Yoshinori Imamura, Tsutomu Nakagawa, Kazuhiro Yamamoto, Naoko Chayahara, Masanori Toyoda, Naomi Kiyota, Midori Hirai, Hironobu Minami
- Organizer
  日本臨床腫瘍学会学術集会
- Place of Presentation
  神戸市
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-15K08588
[Presentation] Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer2015
- Author(s)
  Imamura Y, Mukohara T, Shimono Y, Funakoshi Y, Chayahara N, Toyoda M, Kiyota N, Takao S, Kono S, Nakatsura T, Minami H.
- Organizer
  Aｍｅｒｉｃａｎ　Ａｓｓｏｃｉａｔｉｏｎ　ｆｏｒ　Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ　ａｎｎｕａｌ　ｍｅｅｔｉｎｇ
- Place of Presentation
  Philadelphia
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08588
[Presentation] 乳癌における新規治療標的としてのTyro32013
- Author(s)
  Ekylongo Roudy Chiminch、向原徹、船越洋平、富岡秀夫、片岡優、豊田昌徳、清田尚臣、南博信
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590640
[Presentation] Reversibility of acquired resistance and"addiction"to MET inhibitors2013
- Author(s)
  Funakoshi Y, Mukohara T, Ekyalongo RC, Tomioka H, Kataoka Y, Yohei Shimono, Chayahara N, Toyoda M, Kiyota N, Fujiwara Y, Minami H
- Organizer
  AACR-NCI-EORTC International Conference on "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  ボストン
- Year and Date
  2013-10-20
- Data Source
  KAKENHI-PROJECT-23590639
[Presentation] Excessive MET signaling causes acquired resistance to and addiction to MET inhibitors in MKN45 gastric cancer cell line2013
- Author(s)
  Yohei Funakoshi, Toru Mukohara, Roudy Chiminch Ekyalongo, Hideo Tomioka, Yu Kataoka, Yohei Shimono, Naoko Chayahara, Masanori Toyoda, Naomi Kiyota, Yutaka Fujiwara, Hironobu Minami
- Organizer
  AACR-NCI-EORTC International Conference on "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23590639
[Presentation] Excessive MET signaling causes acquired resistance to and addiction to METinhibitors MET-amplifed cancer cellline2013
- Author(s)
  船越洋平、向原徹、富岡秀夫、Ekylongo Roudy Chiminch、片岡優、豊田昌徳、清田尚美、藤原豊、南博信
- Organizer
  第11回日本臨床腫瘍学会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23590640
[Presentation] Excessive MET signaling causes acquired resistance to and addiction to MET inhibitors in MKN45 gastric cancer cell line2012
- Author(s)
  Funakoshi Y, Mukohara T, Tomioka H, Ekyalonog RC, Kataoka Y, Inui Y, Kawamori Y, Kiyota N, Fujiwara Y, Minami H
- Organizer
  24rh EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Dublin, Ireland
- Data Source
  KAKENHI-PROJECT-23590640
[Presentation] Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line2012
- Author(s)
  Yohei Funakoshi, Toru Mukohara, Hideo Tomioka, Roudy Chiminch Ekyalongo, Yu Kataoka, Yumiko Inui, Yuriko Kawamori, Masanori Toyoda, Naomi Kiyota, Yutaka Fujiwara,Hironobu Minami
- Organizer
  24th EORTC-NCI-AACR Symposium on 'Molecular Targets and Cancer Therapeutics'
- Place of Presentation
  Dublin
- Data Source
  KAKENHI-PROJECT-23590639
[Presentation] Excessive MET signaling causes acquired resistance to and addiction to MET inhibitors in MKN45 gastric cancer cell line2012
- Author(s)
  Funakoshi Y, Mukohara T, Tomioka H, Ekyalongo RC, Kataoka Y, Inui Y, Kawamori Y, Kiyota N, Fujiwara Y, Minami H
- Organizer
  EORTC-NCI-AACR symposium on "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  ダブリン
- Year and Date
  2012-11-07
- Data Source
  KAKENHI-PROJECT-23590639
[Presentation] MCF-7乳癌細胞株におけるinsuylin-like growth factor 1 receptor受容体阻害薬に対する獲得耐性機構2012
- Author(s)
  Ekylongo Roudy Chiminch、向原徹、片岡優、船越洋平、富岡秀夫、清田尚臣、藤原豊、南博信
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590640
[Presentation] Foretinib (GSK1363089) inhibits growth of gastric cancer cell lines through blockade of inter-receptor tyrosine kinase networks2010
- Author(s)
  Mukohara T, Kataoka Y, Tomioka H, Kiyota N, et al.
- Organizer
  22nd EORTC-NCI-AACR symposium on "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  ベルリン(ドイツ)
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21790522
[Presentation] Foretinib (GSK1363089) inhibits growth of gastric cancer cell lines through blockade of inter-receptor tyrosine kinases networks.2010
- Author(s)
  Mukohara T, Kataoka Y, Tomioka H, Kiyota N, Fujiwara Y, Yashiro M, Hirai M, Minami H.
- Organizer
  22^<nd> EORTC-NCI-AACR symposium on "Molecular Targets and Cancer Therapeutics"
- Data Source
  KAKENHI-PROJECT-21790522
[Presentation] Individualized RTK-targeted therapy in breast cancer2009
- Author(s)
  Mukohara T.
- Organizer
  An invited speaker, 24^<th> Nagoya International Cancer Treatment Symposium 2009
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-19790145
[Presentation] PI3K inhibitors overcome resistance to HER2-targeted agents caused by PIK3CA mutations in HER2-amplified breast cancer cell lines.2009
- Author(s)
  Kataoka Y, Mukohara T, et al
- Organizer
  21st EORTC-NCI-AACR symposium on "Molec-ular Targets and Cancer Therapeutics"
- Place of Presentation
  ボストン(米国)
- Year and Date
  2009-11-15
- Data Source
  KAKENHI-PROJECT-21790522

1. MINAMI Hironobu (60450574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. YOSHIDA Masaru (00419475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Ohashi Akihiro (80835249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 桑田健 (00327321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 堀居拓郎 (00361387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 鹿島幸恵 (80831883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 古川孝広 (70444916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 内藤陽一 (90590373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 水野道代 (70287051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 千葉育子 (50863817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大西達也 (70445211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 小田夏実 (40980040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 近藤美紀 (90884148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 浅野美礼 (00273417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 牟田理恵子 (40389937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 田部宏 (80297407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 三島沙織 (00809618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 細野亜古 (00602947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 岡野晋 (90408378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 湯田昌美 (10796923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 秋元哲夫 (10261851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 山下美智代 (90633230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 上田百合 (90617581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. Shimono Yohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

Mukohara Toru 向原 徹

MUKOHARA Toru 向原 徹

Research Projects

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Co-Researchers

A novel germline mutation in the non-coding region of BRCA2 is associated with hereditary breast cancer

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乳がん脳転移症例におけるHER3等治療標的の探索

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Effectiveness and functioning of an online support program to help female cancer patients manage their health and illness

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3D co-culture of breast cancer in malignant effusion and CTC with adipose stem cellsPrincipal Investigator

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Development of ex-vivo sensitivity test for anti-cancer drugs using 3D primary culture and patient-derived xenograftPrincipal Investigator

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individualization of anti-kinase drugs for Asian cancers using genomic and proteomic analysisPrincipal Investigator

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Establishment of the optimal administration method for anticancer agents by proteomics and metabolomics

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Mechanism of PI3K activation and individualized anti-kinase therapy in gastric cancerPrincipal Investigator

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Comprehensive research for individualized use of anti-ErbB2 monoclonal antibodies in breast cancerPrincipal Investigator

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プロテオーム解析を用いた乳がんに対する受容体型チロシンキナーゼ阻害薬治療の個別化Principal Investigator

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[Journal Article] Effectiveness of an online support program to help female cancer patients manage their health and illness: Protocol for a randomized controlled trial2022

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[Journal Article] Impacts of clinicopathological factors on efficacy of trastuzumab deruxtecan in patients with HER2-positive metastatic breast cancer2022

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[Journal Article] Hybrid double-spiral microfluidic chip for RBC-lysis-free enrichment of rare cells from whole blood2022

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Mukohara Toru 向原徹

MUKOHARA Toru 向原徹

[Journal Article] Regulation of MET kinase inhibitor resistance by copy number of MET　in gastric carcinoma cells2014