NAKAHATA Shingo 中畑新吾

… Alternative Names

NAKAHATA Singo 中畑新吾

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Researcher Number	80437938
Other IDs	https://orcid.org/0000-0002-4944-5807
Affiliation (Current)	2025: 鹿児島大学, 医歯学域ヒトレトロウイルス学系, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 鹿児島大学, 医歯学域ヒトレトロウイルス学系, 教授 2021: 鹿児島大学, 総合科学域総合研究学系, 教授 2018 – 2020: 宮崎大学, 医学部, 准教授 2017 – 2018: 宮崎大学, 医学部, 講師 2007 – 2016: University of Miyazaki, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / Tumor biology / Virology Except Principal Investigator Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related / Basic Section 56040:Obstetrics and gynecology-related / Medical genome science / Tumor biology / Basic Section 50010:Tumor biology-related / Biological Sciences
Keywords	Principal Investigator 成人T細胞白血病 / ATL / PI3K/AKT / NDRG2 / 腸内細菌叢 / PTEN / 癌 / CADM1 / ヒトT 細胞白血病ウイルス1 型 / 成人T細胞白血病(ATL) … More / 成人T細胞白血病・リンパ腫 / HTLV-1 / 成人T細胞白血病リンパ腫 / オートファジー / 低酸素ストレス / 低酸素 / AKT / リン酸化 / SCYL2 / 阻害剤 / 低酸素応答 / リン酸化修飾 / がん / PI3K/Akt / ゲノム / 遺伝子 / ウイルス / 白血病 … More Except Principal Investigator HTLV-1 / ATL / NDRG2 / 成人T細胞白血病 / ATLL / 癌 / AMPK / PKM1/M2 / 代謝異常 / Walbrug効果 / ピルビン酸キナーゼ(PK) / がん代謝 / Walburg効果 / がん代謝異常 / ピルビン酸キナーゼ(PKM) / 代謝 / COVID-19 / ELISPOTアッセイ / 妊婦スクリーニング / 先天性サイトメガロウイルス感染症 / CMV IgG avidity / サイトメガロウイルス / 感染 / 重複感染症 / 日和見感染 / ゲノム解析 / 糞線虫 / 腸内細菌 / 糞線虫症 / ペルー / 感染症 / client protein / HTLV1 / sythethic lethality / PP2A / アルギニンメチル化 / HSP90 / PRMT5 / EBL / バイオマーカー / 牛白血病 / BLV / Nox / NADPH oxidase(Nox) / NADPH oxidase (Nox) / すい臓がん / HLV-1 / 活性酸素 / 分子腫瘍学 / NADDPH oxidase(Nox) / 腸内細菌叢 / ゲノム異常 / リン酸化異常 / 感染防御 / NIK / NF-kB / PTEN / ZEB1 / TCF8 / IgSF4 / CADM1 / TSLC1 / TCF8/ZEB1 / ゲノム / 遺伝子 / BCL11B / 成人T細胞白血病(ATL) / TCF8(ZEB1) / TSLC1/CADM1/IgSF4 / EVIl / アセチル化修飾 / Integrin / 接着因子 / 転写因子 / がん幹細胞 / GATA-2 / ITGB4 / ITGA6 / EVI1 Less

Study on immune evasion strategy and mechanism of the promotion of carcinogenesis of HTLV-1-infected cellsPrincipal Investigator
- Principal Investigator
  
  中畑新吾
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kagoshima University
Mechanism of adult T-cell leukaemia pathogenesis dependent on metabolic abnormalities caused by NDRG2 deficiency.
- Principal Investigator
  
  森下和広
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  University of Miyazaki
低侵襲・効率的な胎内サイトメガロウイルス感染症診断のための新たなアルゴリズム開発
- Principal Investigator
  
  金子政時
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  University of Miyazaki
Elucidation of the mechanism of adult T-cell leukemia (ATL) development based on gut microbiota analysisPrincipal Investigator
- Principal Investigator
  
  Nakahata Shingo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kagoshima University
  University of Miyazaki
Comparative analysis of tumorigenesis by HTLV-1 and BLV
- Principal Investigator
  
  Tani Chikako
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  University of Miyazaki
Dysregulation of stress signaling leading to oncogenesis by NDRG2-deficicency
- Principal Investigator
  
  Morishita Kazuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  University of Miyazaki
Comparative genomic analysis of high frequent ATL development due to HTLV-1 superinfection in Peru
- Principal Investigator
  
  Morishita Kazuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical genome science
- Research Institution
  University of Miyazaki
Analysis of the mechanism of hypoxia stress response in adult t-cell leukemia (ATL)Principal Investigator
- Principal Investigator
  
  Nakahata Shingo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  University of Miyazaki
The study on the regulatory mechanism of NADPH oxidase (Nox) 5alpha and 4 redox signaling involved in cancer development
- Principal Investigator
  
  Kamata Tohru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Miyazaki
Analysis of ATL development dependent on abnormalities of intestinal flora
- Principal Investigator
  
  Morishita Kazuhiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Miyazaki
Analysis of ATL leukemogenesis through breakage of defense mechanism of HTLV-1 infection
- Principal Investigator
  
  Kazuhiro Morishita
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Miyazaki
Elucidation of the molecular mechanism involved in dysregulation of PTEN phosphorylation and its physiological role in cancersPrincipal Investigator
- Principal Investigator
  
  Nakahata Shingo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  University of Miyazaki
NDRG2 inactivation and PI3K/Akt pathway activation in cancersPrincipal Investigator
- Principal Investigator
  
  NAKAHATA Shingo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  University of Miyazaki
Molecular analysis of leukemogenesis of adult-T cell leukemia by genomic abnormalities
- Principal Investigator
  
  MORISHITA Kazuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Miyazaki
Evi1遺伝子群による細胞接着を介した白血病幹細胞維持機構の解明
- Principal Investigator
  
  MORISHITA Kazuhiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Miyazaki
Functional analysis of the Zinc finger E-box binding homeobox 1 (ZEB1/TCF8) gene in the multi-step leukemogenesis of adult T-cell leukemia/lymphomaPrincipal Investigator
- Principal Investigator
  
  NAKAHATA Shingo (NAKAHATA Singo)
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  University of Miyazaki

[Book] ATLL発症機構解析研究の進歩2015
- Author(s)
  中畑新吾、森下和広
- Total Pages
  6
- Publisher
  血液内科７１巻　科学評論社
- Data Source
  KAKENHI-PROJECT-25430113
[Book] 成人T細胞白血病/リンパ腫(ATLL)発症の分子機構2015
- Author(s)
  中畑新吾、森下和広
- Total Pages
  4
- Publisher
  日本臨床　日本臨床社
- Data Source
  KAKENHI-PROJECT-25430113
[Book] Annual Review 血液(ATLの発症機構)2010
- Author(s)
  中畑新吾、森下和広
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19790344
[Book] TCF8遺伝子発現抑制による成人T細胞白血病・リンパ腫発症機構2008
- Author(s)
  中畑新吾, 森下和広
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-19790344
[Book] 血液フロンティ18巻(TCF8遺伝子発現抑制による成人T細胞白血病・リンパ腫発症機構)2008
- Author(s)
  中畑新吾、森下和広
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-19790344
[Journal Article] Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review.2023
- Author(s)
  Nakahata S, Enriquez-Vera D, Jahan MI, Sugata K, Satou Y.
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 10 Pages: 1543-1543
- DOI
  10.3390/biom13101543
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07172, KAKENHI-PROJECT-21K08494
[Journal Article] Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma.2020
- Author(s)
  Nakahata S, Syahrul C, Nakatake A, Sakamoto K, Yoshihama M, Nishikata I, Ukai Y, Matsuura T, Kameda T, Shide K, Kubuki Y, Hidaka T, Kitanaka A, Ito A, Takemoto S, Nakano N, Saito M, Iwanaga M, Sagara Y, Mochida K, Amano M, Maeda K, Sueoka E, Okayama A, Utsunomiya A, Shimoda K, Watanabe T, Morishita K.
- Journal Title
  
  Haematologica
  
  Volume: 105 Issue: 2 Pages: 1-1
- DOI
  10.3324/haematol.2019.234096
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05248, KAKENHI-PROJECT-17H03581, KAKENHI-PROJECT-17H03594, KAKENHI-PROJECT-17H04600, KAKENHI-PROJECT-17K09931, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20K08715
[Journal Article] Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2low ATL and various cancer cells.2020
- Author(s)
  Ichikawa T, Shanab O, Nakahata S, Shimosaki S, Manachai N, Ono M, Iha H, Shimoda K, Morishita K
- Journal Title
  
  Biochim Biophys Acta Mol Cell Res
  
  Volume: 1867 Issue: 2 Pages: 118615-118615
- DOI
  10.1016/j.bbamcr.2019.118615
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03581, KAKENHI-PROJECT-17H04600, KAKENHI-PROJECT-17K09931, KAKENHI-PROJECT-18K07238
[Journal Article] CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.2019
- Author(s)
  Suekane A, Saito Y, Nakahata S, Ichikawa T, Ogoh H, Tsujikawa K, Morishita K.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 429-429
- DOI
  10.1038/s41598-018-36796-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07238, KAKENHI-PROJECT-17H03581
[Journal Article] Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.2019
- Author(s)
  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 509 Issue: 1 Pages: 82-82
- DOI
  10.1016/j.bbrc.2018.12.066
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07238, KAKENHI-PROJECT-17H03581
[Journal Article] The regulation of NDRG2 expression during ATLL development after HTLV-1 infection.2019
- Author(s)
  Ichikawa T, Nakahata S, Fujii M, Iha H, Shimoda K, Morishita K.
- Journal Title
  
  Biochim Biophys Acta Mol Basis Dis
  
  Volume: 1865 Issue: 10 Pages: 2633-2646
- DOI
  10.1016/j.bbadis.2019.07.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07238, KAKENHI-PROJECT-17H03581, KAKENHI-PROJECT-17H04600, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-16K09822, KAKENHI-PROJECT-17K09931
[Journal Article] Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB.2019
- Author(s)
  Sarkar B, Nishikata I, Nakahata S, Ichikawa T, Shiraga T, Saha HR, Fujii M, Tanaka Y, Shimoda K, Morishita K.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 3491-3491
- DOI
  10.1038/s41598-019-39424-7
- NAID
  120006825908
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07238, KAKENHI-PROJECT-16K07120, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-16K09822, KAKENHI-PROJECT-17K09931, KAKENHI-PROJECT-17H03581, KAKENHI-PROJECT-17H04600
[Journal Article] Suppression of GPR56 expression by pyrrole-imidazole polyamide represents a novel therapeutic drug for AML with high EVI1 expression2018
- Author(s)
  Saha Hasi Rani、Kaneda-Nakashima Kazuko、Shimosaki Shunsuke、Suekane Akira、Sarkar Bidhan、Saito Yusuke、Ogoh Honami、Nakahata Shingo、Inoue Kentaro、Watanabe Takayoshi、Nagase Hiroki、Morishita Kazuhiro
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-018-32205-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-17H03602, KAKENHI-PROJECT-17H03581
[Journal Article] BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation2017
- Author(s)
  Permatasari H., Nakahata S., Ichikawa T., Morishita K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 490 Issue: 3 Pages: 1086-1092
- DOI
  10.1016/j.bbrc.2017.06.172
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03581
[Journal Article] The loss of NDRG2 expression improves depressive behavior through increased phosphorylation of GSK3β.2015
- Author(s)
  Ichikawa T, Nakahata S, Tamura T, Manachai N, Morishita K.
- Journal Title
  
  Cell Signal.
  
  Volume: 27 Pages: 2087-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15087
[Journal Article] The loss of NDRG2 expression improves depressive behavior through increased phosphorylation of GSK3β. Cell Signal.2015
- Author(s)
  Ichikawa T, Nakahata S, Tamura T, Manachai N, Morishita K.
- Journal Title
  
  Cell Signal
  
  Volume: 27 Issue: 10 Pages: 2087-98
- DOI
  10.1016/j.cellsig.2015.07.012
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08310, KAKENHI-PROJECT-25430113, KAKENHI-PROJECT-25293081
[Journal Article] Loss of NDRG2 enhanced activation of the NF-κB pathway by PTEN and NIK phosphorylation for ATL and other cancer development.2015
- Author(s)
  Ichikawa T, Nakahata S, Fujii M, Iha H, Morishita K.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 12841-12841
- DOI
  10.1038/srep12841
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08310, KAKENHI-PROJECT-15K15087, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-25430113, KAKENHI-PROJECT-25293081
[Journal Article] Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.2014
- Author(s)
  Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, Morishita K.
- Journal Title
  
  Nat Commun
  
  Volume: in press Issue: 1 Pages: 3393-3393
- DOI
  10.1038/ncomms4393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-24591407, KAKENHI-PROJECT-24591928, KAKENHI-PUBLICLY-25118720, KAKENHI-PROJECT-25293081, KAKENHI-PROJECT-25430113, KAKENHI-PROJECT-25860242, KAKENHI-PROJECT-26430130
[Journal Article] Development of a complete human anti-human transferrin receptor C antibody as a novel marker of oral dysplasia and oral cancer.2014
- Author(s)
  5.Nagai K, Nakahata S, Shimosaki S, Tamura T, Kondo Y, Baba T, Taki T, Taniwaki M, Kurosawa G, Sudo Y, Okada S, Sakoda S, Morishita K
- Journal Title
  
  Cancer Med.
  
  Volume: 3 Issue: 4 Pages: 18-26
- DOI
  10.1002/cam4.267
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25118720, KAKENHI-PROJECT-25293081, KAKENHI-PROJECT-25430113
[Journal Article] PP2A inactivation by ROS accumulation2014
- Author(s)
  Nakahata S, Morishita K.
- Journal Title
  
  Blood.
  
  Volume: 124 Issue: 14 Pages: 2163-5
- DOI
  10.1182/blood-2014-08-594093
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25118720, KAKENHI-PROJECT-25293081, KAKENHI-PROJECT-25430113
[Journal Article] Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR562013
- Author(s)
  Saito Y., Kaneda K., Suekane A., Ichihara E., Nakahata S., Yamakawa N., Nagai K., Mizuno N., Kogawa K., Miura I., Itoh H., and Morishita K..
- Journal Title
  
  Leukemia
  
  Volume: 27 Issue: 8 Pages: 1637-1649
- DOI
  10.1038/leu.2013.75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590113, KAKENHI-PUBLICLY-25118720, KAKENHI-PROJECT-25293081, KAKENHI-PUBLICLY-23118523, KAKENHI-PUBLICLY-23121522
[Journal Article] Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma2012
- Author(s)
  Nakahata S, Saito Y, Marutsuka K, Hidaka T, Maeda K, Hatakeyama K, Shiraga T, Goto A, Takamatsu N, Asada Y, Utsunomiya A, Okayama A, Kubuki Y, Shimoda K, Ukai Y, Kurosawa G, Morishita K
- Journal Title
  
  Leukemia
  
  Volume: Jan;26 (6) Issue: 6 Pages: 1238-46
- DOI
  10.1038/leu.2011.379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098, KAKENHI-PROJECT-22590532, KAKENHI-PROJECT-23591397
[Journal Article] Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation2011
- Author(s)
  Nishikata I, Nakahata S, Saito Y, Kaneda K, Ichihara E, Yamakawa N, and Morishita K
- Journal Title
  
  Oncogene
  
  Volume: 30 Issue: 40 Pages: 196-207
- DOI
  10.1038/onc.2011.132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098, KAKENHI-PUBLICLY-23118523
[Journal Article] CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression2011
- Author(s)
  Saito Y, Nakahata S, Yamakawa N, Kaneda K, Ichihara A, Suekane A, and Morishita K
- Journal Title
  
  Leukemia
  
  Volume: 25 Issue: 6 Pages: 921-931
- DOI
  10.1038/leu.2011.36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098, KAKENHI-PUBLICLY-23118523
[Journal Article] NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma.2010
- Author(s)
  Furuta, H., Kondo, Y., Nakahata, S., Hamasaki, M., Sakoda, S., Morishita, K
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 391 Pages: 1785-1791
- URL
  http://dx.doi.org/10.1016/j.bbrc.2009.12.156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098
[Journal Article] Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-β1-mediated growth suppression in adult T-cell leukemia/lymphoma2010
- Author(s)
  Nakahata, S., Yamazaki, H., Nakauchi, H., Morishita, K
- Journal Title
  
  Oncogene
  
  Volume: 29 Issue: 29 Pages: 4157-4159
- DOI
  10.1038/onc.2010.172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098, KAKENHI-PROJECT-22659058
[Journal Article] Downregulation of CDKN1A in adult T-cell leukemia/lymphoma despite overexpression of CDKN1A in human T-lymphotropic virus 1-infected cell lines2010
- Author(s)
  Watanabe, M., Nakahata, S., Hamasaki, M., Saito, Y., Kawano, Y., Hidaka, T., Yamashita, K., Umeki, K., Taki, T., Taniwaki, M., Okayama, A., Morishita, K
- Journal Title
  
  J. Virol
  
  Volume: 84 Issue: 14 Pages: 6966-6977
- DOI
  10.1128/jvi.00073-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098
[Journal Article] Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma2010
- Author(s)
  S.Nakahata
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 4157-4169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098
[Journal Article] Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma.2010
- Author(s)
  Nakahata S
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 4157-4169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790344
[Journal Article] Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to GF-b-mediated growth suppression in adult T-cell leukemia/lympho ma.2010
- Author(s)
  Nakahata S, Yamazaki S, Nakauchi H, Morishita K.
- Journal Title
  
  Oncogene. 29
  
  Pages: 4157-4169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790344
[Journal Article] Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma2009
- Author(s)
  Nakahata, S
- Journal Title
  
  Genes, Chromosomes & Cancer 48
  
  Pages: 768-776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098
[Journal Article] Alteration of enhancer of polycomb 1 at 10p11. 2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma2009
- Author(s)
  Nakahata, S., Saito, Y., Hamasaki, M., Hidaka, T., Arai, Y., Taki, T., Taniwaki, M., Morishita, K
- Journal Title
  
  Genes, Chromosomes & Cancer
  
  Volume: 48 Issue: 9 Pages: 768-776
- DOI
  10.1002/gcc.20681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098
[Journal Article] Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma.2008
- Author(s)
  Hidaka T*, Nakahata S*, Hatakeyama K*, Hamasaki M, Yamashita K, Kohno T, Arai Y, Taki T, Nishida K, Okayama A, Asada Y, Yamaguchi R, Tsubouchi H, Yokota J, Taniwaki M, Higashi Y, Morishita K.
- Journal Title
  
  Blood 112
  
  Pages: 383-393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790344
[Journal Article] 特集「TCF8遺伝子発現抑制による成人T細胞白血病・リンパ腫発症機構」2008
- Author(s)
  中畑新吾
- Journal Title
  
  血液フロンティア医薬ジャーナル社(大阪) 18
  
  Pages: 65-72
- Data Source
  KAKENHI-PROJECT-19790344
[Journal Article] Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma2008
- Author(s)
  Hidaka T, Nakahata S, Hatakeyama K
- Journal Title
  
  Blood 112
  
  Pages: 383-393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790344
[Journal Article] Down-regulation TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lympof ihoma.2008
- Author(s)
  Hidaka T, Nakahata S, Hatakeyama K, Hamasaki M, Yamashita K, Kohno T, Arai Y, Taki T, Nishida K, Okayama A, Asada Y, Yamaguchi R, Tsubouchi H, Yokota J, Taniwaki M, Higashi Y, Morishita K.
- Journal Title
  
  Blood. 112
  
  Pages: 383-393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790344
[Patent] PTENのリン酸化抑制剤又は脱リン酸化剤2010
- Inventor(s)
  森下和広、中畑新吾、濱崎誠
- Industrial Property Rights Holder
  宮崎大学、宮崎県産業支援財団
- Filing Date
  2010-03-26
- Overseas
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 腸内細菌叢と成人T細胞白血病の関連性の解析2021
- Author(s)
  千葉のどか、中畑新吾、山田拓司
- Organizer
  日本バイオインフォマティクス学会
- Data Source
  KAKENHI-PROJECT-19K07693
[Presentation] Cell adhesion molecule 1 (CADM1) is an attractive target for the diagnosis and treatment of adult T-cell leukemia/lymphoma.2019
- Author(s)
  Tomonaga Ichikawa, Ayako Nakatake, Bidhan Sarker, Shingo Nakahata, Kuniyo Sakamoto, Shunsuke Shimosaki, Ichiro Nishikata, Toshiyuki Shiraga, Kazuhiro Morishita
- Organizer
  19th INTERNATIONAL CONFERENCE ON HUMAN RETROVIROLOGY
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] 1.Toward the practical application of novel diagnostic tests and development of early detection markers for Adult T-Cell Leaukemia/Lymphoma in HTLV-1-carriers by host-parasite interaction in Peru.2019
- Author(s)
  Shingo Nakahata, Eiji Nagayasu, Kazuhiro Morishita, Hruhiko Maruyama, Yutaka Suzuki, Masao Iwanaga, Yuetsu Tanaka, Martin Montes, Eduardo Gotuzzo.
- Organizer
  19th International Conference On Human Retrovirology
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] Analysis of the molecular mechanism of metabolism and tumorigenesis through the loss of tumor suppressor gene NDRG22019
- Author(s)
  Tomonaga Ichikawa, Shingo Nakahata, Mitsuru Futakuchi, Kazuhiro Morishita.
- Organizer
  第78回日本癌学会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] PRMT5 inhibition is synthetic lethal with loss of NDRG2 through the suppression of HSP90A in ATL2019
- Author(s)
  Tomonaga Ichikawa, Obeid Shanab, Shingo Nakahata, Masaya Ono, Hidekatsu Iha, and Kazuhiro Morishita.
- Organizer
  第81回日本血液学会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Anti-transferrin receptor1(TFR1)antibody is a promising drug candidate for the treatment of adult T-cell leukemia/lymphoma2019
- Author(s)
  Shingo Nakahata, Shunsuke Shimosaki, Tomonaga Ichikawa, Takuro Kameda, Tomonori Hidaka, Yoko Kubuki, Gene Kurosawa, Kazuya Shimoda, Kazuhiro Morishita
- Organizer
  19th INTERNATIONAL CONFERENCE ON HUMAN RETROVIROLOGY
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] ATLにおけるCADM1発現の機能とその臨床的意義2019
- Author(s)
  中畑新吾、Chilmi Syahrul、Yanuar Fauzi、市川朝永、森下和広
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] 2.ペルーにおける糞線虫重複感染によるATLL発症機構解明とその発症予防・治療法の開発を目指して2019
- Author(s)
  森下和広、中畑新吾、長安英治、丸山治彦、鈴木穣、岩永正子、田中勇悦、Martin Montes、Eduardo Gotuzzo
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] The inhibition of EZH2 suppresses ATL development through the up-regulation of novel tumor suppressor gene2019
- Author(s)
  Tomonaga Ichikawa, Shingo Nakahata, Kazuhiro Morishita.
- Organizer
  第92回日本生化学会.
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Down-regulation of p47 induces high expression of CADM1 via the NF-κB pathway in adult T-cell leukemia/lymphoma2019
- Author(s)
  中畑新吾、Bidhan Sarkar、西片一郎、市川朝永、藤井雅寛、伊波英克、森下和広
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Development of a therapeutic antibody targeting CADM1 for the treatment of ATLL2019
- Author(s)
  Syahrul Chilmi、中畑新吾、市川朝永、松浦正、黒澤仁、森下和広
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] Toward the practical application of novel diagnostic tests and development of early detection markers for Adult T-Cell Leaukemia/Lymphoma in HTLV-1-carriers by host-parasite interaction in peru2019
- Author(s)
  Shingo Nakahata, Eiji Nagayasu, Kazuhiro Morishita, Hruhiko Maruyama, Yutaka Suzuki, Masao Iwanaga, Yuetsu Tanaka, Martin Montes, Eduardo Gotuzzo
- Organizer
  19th INTERNATIONAL CONFERENCE ON HUMAN RETROVIROLOGY
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] ATLにおけるCADM1発現の機能とその臨床的意義2019
- Author(s)
  中畑新吾、Chilmi Syahrul、Yanuar Fauzi、市川朝永、森下和広
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] ATLLにおける可溶性CADM1の産生機序2019
- Author(s)
  吉浜麻生、中畑新吾、市川朝永、森下和広
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Development of a therapeutic antibody targeting CADM1 for the treatment of ATLL2019
- Author(s)
  Syahrul Chilmi、中畑新吾、市川朝永、松浦正、黒澤仁、森下和広
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Toward the practical application of novel diagnostic tests and development of early detection markers for Adult T-Cell Leaukemia/Lymphoma in HTLV-1-carriers by host-parasite interaction in peru2019
- Author(s)
  Shingo Nakahata, Eiji Nagayasu, Kazuhiro Morishita, Hruhiko Maruyama, Yutaka Suzuki, Masao Iwanaga, Yuetsu Tanaka, Martin Montes, Eduardo Gotuzzo
- Organizer
  19th INTERNATIONAL CONFERENCE ON HUMAN RETROVIROLOGY
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] ATLLにおける可溶性CADM1の産生機序2019
- Author(s)
  吉浜麻生、中畑新吾、市川朝永、森下和広
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] がん抑制遺伝子NDRG2発現低下によるJak/STAT情報伝達系活性化機構2019
- Author(s)
  市川朝永、中畑新吾、尾野雅哉、中武彩子、阪本訓代、森下和広
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] ATLにおける可溶型CADM1の産生亢進機構2019
- Author(s)
  吉浜麻生, 中畑新吾, 市川朝永, 森下和広
- Organizer
  第78回日本癌学会.
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Cell adhesion molecule 1 (CADM1) is an attractive target for the diagnosis and treatment of adult T-cell leukemia/lymphoma.2019
- Author(s)
  Tomonaga Ichikawa, Ayako Nakatake, Bidhan Sarker, Shingo Nakahata, Kuniyo Sakamoto, Shunsuke Shimosaki, Ichiro Nishikata, Toshiyuki Shiraga, Kazuhiro Morishita
- Organizer
  19th INTERNATIONAL CONFERENCE ON HUMAN RETROVIROLOGY
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] EZH2 overexpression in ATL promotes epigenetic silencing of tumor suppressor gene NDRG2.2019
- Author(s)
  Tomonaga Ichikawa, Shingo Nakahata, and Kazuhiro Morishita.
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] 新規がん抑制遺伝子ＮＤＲＧ2欠損マウスにおける脂質代謝異常および腫瘍形成機能の解析2018
- Author(s)
  市川朝永、中畑新吾、山口良二、二口充、森下和広
- Organizer
  先端モデル動物支援プラットフォーム
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] トランスフェリン受容体抗体はモガムリズマブ治療難治性のATLLの増殖抑制に有効である.2018
- Author(s)
  中畑新吾、下崎俊介、市川朝永、亀田拓郎、日高智徳、久冨木庸子、黒澤仁、下田和哉、森下和広.
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] ATLにおけるオートファジーによるNF-κB負の制御因子p47の不活化は、NF-κBシグナルを増強しCADM1高発現をもたらす2018
- Author(s)
  中畑新吾、Bidhan Sarkar、西片一郎、市川朝永、藤井雅寛、井上純一郎、伊波英克、下田和哉、森下和広
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K07120
[Presentation] Identification of novel antisense RNAs in the genome of bovine leukemia virus (BLV).2018
- Author(s)
  Shingo Nakahata, Chikako Tani, Tomonaga Ichikawa, Hirohisa Mekata, Kazuhiro Morishita
- Organizer
  第30回世界牛病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Identification of novel antisense RNAs in the genome of bovine leukemia virus (BLV).2018
- Author(s)
  Shingo Nakahata, Chikako Tani, Tomonaga Ichikawa, Hirohisa Mekata, Kazuhiro Morishita.
- Organizer
  第30回世界牛病学会2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] EZH2 overexpression in ATL promotes epigenetic silencing of tumor suppressor gene NDRG2.2018
- Author(s)
  Tomonaga Ichikawa, Shingo Nakahata, and Kazuhiro Morishita.
- Organizer
  The 9th JSH International Symposium
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] アルギニンメチル化転移酵素PRMT5異常活性によるATL発症機構の解析.2018
- Author(s)
  市川朝永、Obeid Shanab、中畑新吾、尾野雅哉、伊波英克、中武彩子、阪本訓代、森下和広
- Organizer
  第5回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] トランスフェリン受容体抗体はモガムリズマブ治療難治性のATLLの増殖抑制に有効である.2018
- Author(s)
  中畑新吾、下崎俊介、市川朝永、亀田拓郎、日高智徳、久冨木庸子、黒澤仁、下田和哉、森下和広.
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] HTLV-1 infection in Peru and Japan2018
- Author(s)
  森下和広、中畑新吾、長安英治、丸山治彦、鈴木穣、岩永正子、田中勇悦、Martin Montes、Eduardo Gotuzzo
- Organizer
  第18回日秘国際医学シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] ATLにおけるオートファジーによるNF-κB負の制御因子p47の不活化は、NF-κBシグナルを増強しCADM1高発現をもたらす.2018
- Author(s)
  中畑新吾、Bidhan Sarkar、西片一郎、市川朝永、藤井雅寛、井上純一郎、伊波英克、下田和哉、森下和広.
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] High efficacy of anti-TFR1 antibody against the growth of mogamulizmab-resistant ATLL cells2018
- Author(s)
  Shingo Nakahata, Shunsuke Shimosaki, Tomonaga Ichikawa, Takuro Kameda, Tomonori Hidaka, Yoko Kubuki, Gene Kurosawa, Kazuya Shimoda, Kazuhiro Morishita.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Short-form of BCL11B contributes to tumorigenesis of adult T-cell leukemia/lymphoma.2018
- Author(s)
  Happy Kurnia Permatasari, Shingo Nakahata, Tomonaga Ichikawa, Kotaro Shide, Takuro Kameda, Kazuya Shimoda, Masaya Ono, Kazuhiro Morishita.
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] アルギニンメチル化転移酵素PRMT5異常活性によるATL発症機構の解析.2018
- Author(s)
  市川朝永、Obeid Shanab、中畑新吾、尾野雅哉、伊波英克、中武彩子、阪本訓代、森下和広
- Organizer
  第5回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] EZH2 overexpression in ATL promotes epigenetic silencing of tumor suppressor gene NDRG22018
- Author(s)
  Tomonaga Ichikawa, Shingo Nakahata, and Kazuhiro Morishita.
- Organizer
  The 9th JSH International Symposium.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Overexpression of EZH2 confers ATL development through the suppression of tumor suppressor gene NDRG2.2018
- Author(s)
  Tomonaga Ichikawa, Shingo Nakahata, Kazuhiro Morishita.
- Organizer
  第80回日本血液学会.
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] Overexpression of EZH2 confers ATL development through the suppression of tumor suppressor gene NDRG2.2018
- Author(s)
  Tomonaga Ichikawa, Shingo Nakahata, Kazuhiro Morishita.
- Organizer
  第80回日本血液学会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] ATLにおけるオートファジーによるNF-κB負の制御因子p47の不活化は、NF-κBシグナルを増強しCADM1高発現をもたらす.2018
- Author(s)
  中畑新吾、Bidhan Sarkar、西片一郎、市川朝永、藤井雅寛、井上純一郎、伊波英克、下田和哉、森下和広.
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] Maintenance of HSP90A by PRMT5 arginine methylation by NDRG2-deficient ATLL and other cancers2018
- Author(s)
  Kazuhiro Morishita1 , Tomonaga Ichikawa1 , Shingo Nakahata1 , Masaya Ono
- Organizer
  11th AACR-JCA Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] High efficacy of anti-TFR1 antibody against the growth of mogamulizmab-resistant ATLL cells.2018
- Author(s)
  Shingo Nakahata, Shunsuke Shimosaki, Tomonaga Ichikawa, Takuro Kameda, Tomonori Hidaka, Yoko Kubuki, Gene Kurosawa, Kazuya Shimoda, Kazuhiro Morishita.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] Identification of novel antisense RNAs in the genome of bovine leukemia virus (BLV)2018
- Author(s)
  Shingo Nakahata, Chikako Tani, Tomonaga Ichikawa, Hirohisa Mekata, Kazuhiro Morishita
- Organizer
  第30回世界牛病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07203
[Presentation] Short-form of BCL11B contributes to tumorigenesis of adult T-cell leukemia/lymphoma.2018
- Author(s)
  Happy Kurnia Permatasari, Shingo Nakahata, Tomonaga Ichikawa, Kotaro Shide, Takuro Kameda, Kazuya Shimoda, Masaya Ono, Kazuhiro Morishita.
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Arginine methylation of HSP90A by protein arginine methyltransferase PRMT5 promotes development of adult T-cell leukemia.2018
- Author(s)
  Tomonaga Ichikawa, Obeid Shanab, Shingo Nakahata, Masaya Ono, Hidekatsu Iha, and Kazuhiro Morishita
- Organizer
  第77回日本癌学会.
- Data Source
  KAKENHI-PROJECT-17H04600
[Presentation] Arginine methylation of HSP90A by protein arginine methyltransferase PRMT5 promotes development of adult T-cell leukemia.2018
- Author(s)
  Tomonaga Ichikawa, Obeid Shanab, Shingo Nakahata, Masaya Ono, Hidekatsu Iha, and Kazuhiro Morishita.
- Organizer
  第77回日本癌学会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] ATLにおけるNDRG2発現低下は細胞ストレス応答異常に関与する2017
- Author(s)
  中畑新吾、市川朝永、斎藤祐介、滝智彦、谷脇雅史、森下和広
- Organizer
  第4回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-16K07120
[Presentation] Short-from of BCL11B contributes to tumorigenesis of adult T-cell leukemia2017
- Author(s)
  Happy Permatasari,　中畑新吾,　市川朝永,　齋藤祐介,　滝智彦,　谷脇雅史,　森下和広
- Organizer
  平成29年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Down-regulation of p47 induces high expression of CADM1 via the NF-kB pathway in adult T-cell leukemia2017
- Author(s)
  Bidhan Sarkar,　西片一朗,　中畑新吾,　市川朝永,　藤井雅寛,　伊波英克,　森下和広
- Organizer
  平成29年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] アルギニンメチル化によるHSP90A活性調節機構の解析2017
- Author(s)
  市川朝永,　Obeid Shanab,　中畑新吾,　伊波英克,　尾野雅哉,　中武彩子,　阪本訓代,　森下和広
- Organizer
  平成29年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] 新規がん抑制遺伝子NDRG2によるがん進展および転移の分子機構の解明2017
- Author(s)
  市川朝永、田村知丈、中畑新吾、二口充、森下和広.
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] 成人T細胞白血病(ATL)に対するアルギニンメチル化転移酵素PRMT5阻害による抗腫瘍効果の検討2017
- Author(s)
  市川朝永、Obeid Shanab、中畑新吾、伊波英克、尾野雅哉、中武彩子、阪本訓代、森下和広
- Organizer
  第4回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] Synthetic lethality of PRMT5 inhibition in NDRG2-deficient adult T-cell leukemia through HSP90A dysfunction2017
- Author(s)
  Tomonaga Ichikawa, Obeid Shanab, Shingo Nakahata, Shunsuke Shimosaki, Nawin Manachai, Hidekatsu Iha, Kazuya Shimoda, Masaya Ono, Mohammed N. Ismail, Ahmed Y. Nassar and Kazuhiro Morishita. 
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] ATLにおけるNDRG2発現低下は細胞ストレス応答異常に関与する2017
- Author(s)
  中畑新吾、市川朝永、斎藤祐介、滝智彦、谷脇雅史、森下和広
- Organizer
  第4回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-17H03581
[Presentation] ATLLにおけるNDRG2発現低下はPI3K/AKTシグナルの恒常的活性化を介して低酸素抵抗性を来す2016
- Author(s)
  中畑新吾、市川朝永、斎藤祐介、滝智彦、谷脇雅史、森下和広
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K07120
[Presentation] NDRG2 down-regulation induces hypoxic resistance via activation of PI3K/AKT signaling in ATLL.2016
- Author(s)
  Singo Nakahata, Tomonaga Ichikawa, Yusuke saito, Tomokiko Taki, Masafumi Taniwaki, Kazuhiro Morishita
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K07120
[Presentation] NDRG2 regulates the cell growth response to hypoxia via control of the PI3K/AKT pathway.2016
- Author(s)
  Shingo Nakahata, Tomonaga Ichikawa, Yusuke Saito, Tomohiko Taki, Masafumi Taniwaki, Kazuhiro Morishita.
- Organizer
  The 5th JCA-AACR Special Joint Conference
- Place of Presentation
  千葉県浦安市
- Year and Date
  2016-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07120
[Presentation] HTLV-1感染によるがん抑制遺伝子NDRG2発現調節機構の解析2015
- Author(s)
  市川朝永、中畑新吾、中武彩子、森永樹、森下和広
- Organizer
  第二回HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所講堂（東京都港区）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] 成人T細胞白血病に対する抗トランスフェリン受容体抗体治療薬の開発2015
- Author(s)
  下崎俊介、黒澤仁、張黎臨、須藤幸夫、黒澤和良、中畑新吾、市川朝永、森下和広
- Organizer
  第二回HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所講堂 (東京都港区）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-15K15087
[Presentation] Proteosomal degradation of p47 by HTLV-1 Tax and p47 promoter methylation enhanced CADM1 expression in ATLL cells2015
- Author(s)
  Ichiro Nishikawa, Shingo Nakahata, Tomonaga Ichikawa, Masahiro Fujii, Hidekatsu Iha, Yuetsu Tanaka, Kazuhiro Morishita
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学大会・合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K15087
[Presentation] Down-regulation of NDRG2 plays an important role in ATLL leukemogenesis via the PTEN-mediated PI3K/AKT signaling pathway.2015
- Author(s)
  中畑新吾、市川朝永、齋藤祐介、新井康仁、滝智彦、谷脇雅史、森下和広
- Organizer
  44th International Society for Experimental Hematology Annual Scientific Meeting
- Place of Presentation
  国立京都国際会議場
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430113
[Presentation] ATL細胞におけるCADM1高発現はP47発現阻害に働くHTLV1 Taxとプロモーターメチル化に依存する2015
- Author(s)
  森下和広、西片一朗、中畑新吾、市川朝永、藤井雅寛、伊波英克、田中勇悦
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] Dysregulation of hypoxia response by NDRG2 down-regulation in ATL2015
- Author(s)
  中畑新吾、市川朝永、斎藤祐介、滝智彦、谷脇雅史、森下和広
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15K15087
[Presentation] 成人T細胞白血病に対する抗hTfR抗体を用いた医薬品の開発に関する研究2015
- Author(s)
  下崎俊介、中畑新吾、市川朝永、森下和広、黒澤仁、黒澤良和、張黎臨、須藤幸夫
- Organizer
  第22回技術・研究発表交流会
- Place of Presentation
  宮崎市民プラザ (宮崎県宮崎市）
- Year and Date
  2015-09-30
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] NDRG2発現低下がAKT情報伝達系の亢進を介して抗うつ状態を改善する2015
- Author(s)
  市川朝永、中畑新吾、田村知丈、Nawin　Manachai、森下和広
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学大会・合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] ATL細胞におけるCADM1高発現はP47発現阻害に働くHTLV1 Taxとプロモーターメチル化に依存する2015
- Author(s)
  森下和広、西片一朗、中畑新吾、市川朝永、藤井雅寛、伊波英克、田中勇悦
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市)
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K15087
[Presentation] Down-regulation of NDRG2 plays an important role in ATLL leukemogenesis via the PTEN-mediated PI3K/AKT signaling pathway.2015
- Author(s)
  Shingo Nakahata, Tomonaga Ichikawa, Yusuke Saito, Yasuhito Arai, Tomohiko Taki, Masafumi Taniwaki, Kazuhiro Morishita
- Organizer
  44th Annual Scientific Meeting of The Society for Hematology and Stem Cells (ISEH 2015)
- Place of Presentation
  国立京都国際会館（京都府左京区）
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] NDRG2発現低下がPTENおよびNIKリン酸化によってNF-κB活性が促進されATLLを発症する2015
- Author(s)
  市川朝永、中畑新吾、藤井雅寛、伊波英克、森下和広
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市)
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K15087
[Presentation] HTLV-1感染によるがん抑制遺伝子NDRG2発現調節機構の解析2015
- Author(s)
  市川朝永、中畑新吾、中武彩子、森永樹、森下和広
- Organizer
  第二回HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所講堂 (東京都港区）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-15K15087
[Presentation] ATLにおけるNDRG2発現低下による低酸素応答の異常調節2015
- Author(s)
  中畑新吾、市川朝永、齋藤祐介、滝智彦、谷脇雅史、森下和広
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂、他
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25430113
[Presentation] NDRG2は口腔癌の発癌およびリンパ節転移に関与する癌抑制遺伝子の候補である2015
- Author(s)
  田村知丈、市川朝永、中畑新吾、近藤雄大、馬場貴、長井健太郎、田川友梨、山本晃士、二口充、山下善弘、
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] ATLにおけるNDRG2発現低下による低酸素応答の異常調節2015
- Author(s)
  中畑新吾、市川朝永、齋藤祐介、滝智彦、谷脇雅史、森下和広
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学大会・合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] ATLにおけるNDRG2発現低下による低酸素応答の異常調節2015
- Author(s)
  中畑新吾、市川朝永、齋藤祐介、滝智彦、谷脇雅史、森下和広
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25430113
[Presentation] NDRG2はPI3Kシグナル伝達系の負のフィードバック因子として働く―低酸素ストレス抵抗性への関与2015
- Author(s)
  中畑新吾、市川朝永、齋藤祐介、森下和広
- Organizer
  第二回HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所講堂（東京都港区）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] NDRG2はPI3Kシグナル伝達系の負のフィードバック因子として働く―低酸素ストレス抵抗性への関与2015
- Author(s)
  中畑新吾、市川朝永、齋藤祐介、森下和広
- Organizer
  第二回HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所講堂 (東京都港区）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-15K15087
[Presentation] Proteosomal degradation of p47 by HTLV-1 Tax and p47 promoter methylation enhanced CADM1 expression in ATLL cells2015
- Author(s)
  Ichiro Nishikawa, Shingo Nakahata, Tomonaga Ichikawa, Masahiro Fujii, Hidekatsu Iha, Yuetsu Tanaka, Kazuhiro Morishita
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学大会・合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] 成人T細胞白血病に対する抗トランスフェリン受容体抗体治療薬の開発2015
- Author(s)
  下崎俊介、黒澤仁、張黎臨、須藤幸夫、黒澤和良、中畑新吾、市川朝永、森下和広
- Organizer
  第二回HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所講堂（東京都港区）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] Dysregulation of hypoxia response by NDRG2 down-regulation in ATL2015
- Author(s)
  中畑新吾、市川朝永、斎藤祐介、滝智彦、谷脇雅史、森下和広
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] NDRG2発現低下がPTENおよびNIKリン酸化によってNF-κB活性が促進されATLLを発症する2015
- Author(s)
  市川朝永、中畑新吾、藤井雅寛、伊波英克、森下和広
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] NDRG2はPI3Kシグナル伝達系の負のフィードバック因子として働く―低酸素ストレス抵抗性への関与2015
- Author(s)
  中畑新吾、市川朝永、齋藤祐介、森下和広
- Organizer
  第２回HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-25430113
[Presentation] NDRG2はPPA2を介してNIK活性を制御し、恒常的NF-ｋB活性を抑制する2014
- Author(s)
  市川朝永、中畑新吾、藤井雅寛、伊波英克、森下和広
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] NDRG2 plays a pivotal role in ATLL leukaemogenesis by regulating the PTEN-mediated PI3K/AKT signalling pathway.2013
- Author(s)
  Shingo Nakahata, Tomonaga Ichikawa, Yusuke Saito, Yasuhito Arai, Tomohiko Taki, Masafumi Taniwaki, Kazuhiro Morishita
- Organizer
  16th International Conference on Human Retrovirology: HTLV and Related Viruses.
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-25430113
[Presentation] ATLにおけるNDRG2発現低下はPTEN不活性化に伴う恒常的なPI3K情報伝達系活性化を導く2013
- Author(s)
  中畑新吾、市川朝永、斎藤祐介、新井康仁、滝智彦、谷脇雅史、森下和広
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  ロイトン札幌、さっぽろ芸文館、札幌市教育文化会館
- Data Source
  KAKENHI-PROJECT-25430113
[Presentation] 癌細胞におけるNDRG2の不活性化はPTENの恒常的なリン酸化を促し、PI3K/AKT経路の活性化を引き起こす2013
- Author(s)
  中畑新吾、市川朝永、斎藤祐介、新井康仁、滝智彦、谷脇雅史、森下和広
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25430113
[Presentation] NDRG2, a novel regulator of phosphorylation of PTEN at S380/T382/T383, works as a tumor suppressor.2012
- Author(s)
  中畑新吾
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23701061
[Presentation] ATLにおけるNDRG2発現低下はPTEN不活性化に伴う恒常的なPI3K情報伝達系活性化を導く。2012
- Author(s)
  中畑新吾
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23701061
[Presentation] ATLLにおけるNDRG2発現低下はPTEN不活性化に伴う恒常的なPI3K情報伝達系活性化を導く。2012
- Author(s)
  中畑新吾
- Organizer
  第5回HTLV-1研究会
- Place of Presentation
  東京大学医科学研究所
- Data Source
  KAKENHI-PROJECT-23701061
[Presentation] ATL における NDRG2 発現低下は PTEN 不活性化に伴う恒常的な PI3K情報伝達系活性化を導く2012
- Author(s)
  中畑新吾
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23701061
[Presentation] NDRG2, a novel regulator ofphosphorylation of PTEN atS380/T382/T383, works as a tumor suppressor.2012
- Author(s)
  中畑新吾
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23701061
[Presentation] DRG2, a novel regulator ofphosphorylation of PTEN atS380/T382/T383, works as a tumorsuppressor.2012
- Author(s)
  中畑新吾
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市教育文化会館
- Data Source
  KAKENHI-PROJECT-23701061
[Presentation] NDRG2, a novel regulator of phosphorylation of PTEN at S380/T382/T383, works as a tumor suppressor.2012
- Author(s)
  中畑新吾
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市教育文化会館
- Data Source
  KAKENHI-PROJECT-23701061
[Presentation] ATLL における NDRG2 発現低下は PTEN 不活性化に伴う恒常的な PI3K情報伝達系活性化を導く2012
- Author(s)
  中畑新吾
- Organizer
  第5回 HTLV-1研究会
- Place of Presentation
  東京大学医科学研究所
- Data Source
  KAKENHI-PROJECT-23701061
[Presentation] T細胞特異的TSLC1 TgマウスはATL様病態を示す2011
- Author(s)
  市川朝永、中畑新吾、山口良二、西片一朗、森下和広
- Organizer
  第4回HTLV-1研究会
- Place of Presentation
  東京都文京区
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 癌抑制遺伝子NDRG2の炎症反応制御機構2011
- Author(s)
  市川朝永、中畑新吾、近藤雄大、長井健太郎、迫田隅男、森下和広
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] NDRG2は成人T細胞白血病リンパ腫においてがん抑制遺伝子として働く2011
- Author(s)
  中畑新吾、市川朝永、齋藤祐介、新井康仁、滝智彦、谷脇雅史、森下和広
- Organizer
  第4回HTLV-1研究会
- Place of Presentation
  東京都文京区
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 成人T細胞白血病におけるがん抑制遺伝子候補NDRG2の同定2011
- Author(s)
  中畑新吾、市川朝永、齋藤祐介、新井康仁、滝智彦、谷脇雅史、森下和広
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] Promoter methylation and down-regulation of ZEB1 are associated with low expression of CDKNIA in ATL-cells2010
- Author(s)
  Nakahata, S., Watanabe, M., Saito, Y., Morishita, K
- Organizer
  69th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  大阪市
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] Promoter methylation and down-regulation of ZEB1 are associated with low expression of CDKN1A in ATL cells2010
- Author(s)
  Nakahata, S.
- Organizer
  第33回日本分子生物学会年会/第83回日本生化学会大会合同大会
- Place of Presentation
  神戸市中央区
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 成人T細胞白血病細胞におけるCDKN1A遺伝子の転写はプロモーターのメチル化とZEB1発現低下により抑制される2010
- Author(s)
  中畑新吾
- Organizer
  第73回日本血液学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] 成人T細胞白血病におけるCDKN1A遺伝子の転写はプロモーターのメチル化とZEB1発現低下により抑制される2010
- Author(s)
  Nakahata, S.
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜市西区
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] Promoter methylation and down-regulation of ZEB1 are associated with low expression of CDKNIA in ATL-cells2010
- Author(s)
  中畑新吾
- Organizer
  69th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  大阪市北区
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 成人T細胞白血病細胞におけるCDKN1A遺伝子の転写はプロモーターのメチル化とZEB1 発現低下により抑制される2010
- Author(s)
  中畑新吾
- Organizer
  第73回日本血液学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] ATL細胞におけるCDKN1A遺伝子の転写はプロモーターのメチル化とZEB1発現低下により抑制される2010
- Author(s)
  渡邊正明, 中畑新吾, 齋藤祐介, 森下和広
- Organizer
  第3回HTLV-1研究会・合同班会議
- Place of Presentation
  東京都港区
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] CADM1特異抗体を用いたATLL(成人T細胞白血病・リンパ腫)診断・治療法の開発2010
- Author(s)
  眞鍋香澄, 高松尚文, 丸塚浩助, 日高智徳, 中畑新吾, 前田宏一, 齋藤祐介, 濱崎誠, 一ノ瀬孝子, 岩田喬子, 畠山金太, 鵜飼由範, 岡山昭彦, 黒沢仁, 浅田祐士郎, 宇都宮與, 森下和広
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 成人T細胞白血病におけるCDKN1A遺伝子の転写はプロモーターのメチル化とZEB1発現低下により抑制される2010
- Author(s)
  中畑新吾, 渡邊正明, 濱崎誠, 齋藤祐介, 河野洋平, 森下和広
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] Promoter methytation and down-regulation of ZEB1 are associated with low expression of CDKN1A in ATL cells2010
- Author(s)
  中畑新吾
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] ATL細胞におけるCDKN1A遺伝子の転写はプロモーターのメチル化とZEB1発現低下により抑制される2010
- Author(s)
  中畑新吾
- Organizer
  第3回HTLV-1研究会・合同斑会議
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] Promoter methylation and down-regulation of ZEB1 are associated with low expression of CDKN1A in ATL cells2010
- Author(s)
  中畑新吾
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] Promoter methylation and down-regulation of ZEB1 are associated with low expression of CDKNIA in ATL cells2010
- Author(s)
  Nakahata, S.
- Organizer
  69th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  大阪市北区
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] Promoter methylation and down-regulation of ZEB1 are associated with low expression of CDKN1A in ATL cells2010
- Author(s)
  Nakahata, S., Watanabe, M., Saito, Y., Morishita, K
- Organizer
  第33回日本分子生物学会年会/第83回日本生化学会大会合同大会
- Place of Presentation
  神戸市
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 成人T細胞白血病・リンパ腫(ATLL)のTSLC1/IgSF4による診断応用2009
- Author(s)
  眞鍋香澄, 高松尚文, 日高智徳, 中畑新吾, 前田宏一, 濱崎誠, 岩田喬子, 鵜飼由範, 岡山昭彦, 坪内博仁, 黒沢仁, 宇都宮與, 森下和広
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] TCF8は Smad7を抑制しATLのTGF-betal 不能性を解除する2009
- Author(s)
  中畑新吾
- Organizer
  日本分子生物学会第9回春季シンポジウム
- Place of Presentation
  シーガイヤワールドコンベンションセンター(宮崎市)
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 成人T細胞白血病リンパ腫(ATLL)におけるZEB1/TCF8転写抑制はCCNG2及びCDKN1Aの転写抑制をもたらす2009
- Author(s)
  中畑新吾, 浜崎誠, 渡邊正明, 森下和広
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] Down-regulation of CDKN1A transcription by ZEB1/TCF8 inactivation in adult T-cell leukemia.2009
- Author(s)
  中畑新吾
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] 成人T細胞白血病リンパ腫(ATLL)におけるZEB1/TCF8転写抑制はCCNG2及びCDKNIAの転写抑制をもたらす2009
- Author(s)
  中畑新吾
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 成人T細胞白血病リンパ腫(ATLL)におけるZEB1/TCF8転写抑制はCCNG2及びCDKN1Aの転写抑制をもたらす。2009
- Author(s)
  中畑新吾
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] Down-regulation of CDKN1A transcription by ZEB1/TCF8 inactivation in adult T-cell leukemia2009
- Author(s)
  Nakahata, S., Hamasaki, M., Watanabe, M., and Morishita, K
- Organizer
  68th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  横浜市
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] Diagnostic application using TSLC1/IgSF4 antibodies to Adult T cell leukemia/lymphoma(ATLL)2009
- Author(s)
  Manabe, K., Takamatsu, N., Hidaka, T., Nakahata, S., Naeda, K., Hamasaki, M., Iwata, T., Ukai, Y., Okayama, A., Horiuchi, H., Kurosawa, G., Utsunomiya, A., and Morishita, K
- Organizer
  68th Annual Meeting of the JapaneseCancer Association
- Place of Presentation
  横浜市
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] ATLLにおけるZEB1転写抑制はCCNG2及びCDKN1Aの転写抑制を介した細胞増殖すきたす。2009
- Author(s)
  中畑新吾
- Organizer
  第2回HTLV-1研究会・合同斑会議
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] NDRG2 is a candidate tumor suppressor gene in adult-T cell leukemia2009
- Author(s)
  Hamasaki, M., Nakahata, S., Saito, Y., Kawano, Y, Arai, Y, Taki, T., Taniwaki, M., and Morishita, K
- Organizer
  68th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  横浜市
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] ATLLにおけるZEB1転写抑制はCCNG2及びCDKN1Aの転写抑制を介した細胞増殖をきたす2009
- Author(s)
  中畑新吾
- Organizer
  第2回HTLV-1研究会・合同斑会議
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] 成人T細胞白血病リンパ腫(ATLL)におけるZEB1/TCF8転写抑制はCCNG2及びCDKN1Aの転写抑制をもたらす2009
- Author(s)
  中畑新吾
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] Identification and characterlization of tumor suppressor genes in ATL by chromosomal and genetic analyses2009
- Author(s)
  Morishita, K., Taniwaki, M., and Nakahata, S
- Organizer
  68th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  横浜市
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] TCF8はSmad7を抑制しATLのTGF-betal不能性を解除する2009
- Author(s)
  中畑新吾, 濱崎誠, 齋藤祐介, 森下和広
- Organizer
  日本分子生物学会第9回春季シンポジウム
- Place of Presentation
  宮崎市
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 成人T細胞白血病(ATL)におけるZEB1/TCF8不活性化によるCDKN1Aの転写抑制2009
- Author(s)
  中畑新吾
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 口腔扁平上皮癌におけるNDRG2遺伝子の発現とその制御機構の解析2009
- Author(s)
  古田浩史, 近藤雄大, 濱崎誠, 中畑新吾, 迫田隅男, 森下和広
- Organizer
  日本分子生物学会第9回春季シンポジウム
- Place of Presentation
  宮崎市
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] ATLLのTGF-betal不能性はゲノム異常によるTCF8発現低下とSMAD7高発現によりもたらされる2008
- Author(s)
  中畑新吾
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] TCF8はSmad7を抑制しATLのTGF-betal不能性を解除する2008
- Author(s)
  中畑新吾
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-10-12
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] TCF8はSmad7を抑制しATLのTGF-beta1不能性を解除する2008
- Author(s)
  中畑新吾
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-10-12
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] TCF8遺伝子発現低下によるATLL発症機構の解析2008
- Author(s)
  中畑新吾
- Organizer
  第1回HTLV-1研究会・合同斑会議
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2008-08-24
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] TCF8 expression overcomes the resistance to TGFbetal-induced growth in hibition by Smad7 overexpression in ATL2008
- Author(s)
  中畑新吾
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] TCF8遺伝子の発現低下はT細胞分化過程におけるTCF-betalの選択を回避しATLLの発症に関与する2007
- Author(s)
  中畑新吾
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] Downregulation of TCF8 is involved in ATLL development by the escape from TGF-beta1 during T cell differentiation.2007
- Author(s)
  中畑新吾
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] TCF8遺伝子発現低下によるATLL発症機構の解析2007
- Author(s)
  中畑新吾
- Organizer
  第69回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] Downregulation of TCF8 is involved in ATLL development by the escape from TGF-beta1 during T cell differentiation.2007
- Author(s)
  中畑新吾
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] TCF8遺伝子発現低下によるATLL発症機構の解析2007
- Author(s)
  中畑新吾
- Organizer
  第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19790344
[Presentation] がん抑制遺伝子NDRG2によるHTLV-1/Tax誘導性NFκB活性抑制機構の解析
- Author(s)
  市川朝永、中畑新吾、森下和広
- Organizer
  第34回日本炎症・再生医学会.
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] がん抑制遺伝子NDRG2欠損マウスによる4-NQO誘導性口腔がん発症機構の解析
- Author(s)
  田村知丈、市川朝永、中畑新吾、近藤雄大、馬場貴、長井健太郎、山下善弘、森下和広
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] Identification of NDRG2 as a candidate tumor suppressor gene in adult T-cell leukemia
- Author(s)
  中畑新吾
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23701061
[Presentation] がん抑制遺伝子NDRG2欠損マウスによる4-NQO誘導性口腔がん発症機構の解析.
- Author(s)
  市川朝永、田村知丈、中畑新吾、迫田隅男、森下和広
- Organizer
  第86回日本生化学会大会.
- Place of Presentation
  横浜市　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] NDRG2はPP2Aリクルーターとして PTEN及びNIK活性調節に関わる.
- Author(s)
  市川朝永、中畑新吾、藤井雅寛、伊波英克、森下和広
- Organizer
  HTLV-1研究会・シンポジウム
- Place of Presentation
  港区　東京大学医科学研究所
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] 新規がん抑制遺伝子Ndrg2欠損ﾏｳｽはAKT活性の亢進を介して抗うつ状態を改善する
- Author(s)
  市川朝永、中畑新吾、森下和広
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-16 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] ATLやその他のがんにおけるNDRG2発現低下はPTENリン酸化異常をきたし、PI3K/AKT経路を活性化させる
- Author(s)
  中畑新吾、市川朝永、齋藤祐介、滝智彦、谷脇雅史、森下和広
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] NDRG2 S332 phosphorylation is necessary to recruit PP2A to dephosphorylate PTEN in a feedback loop in the PI3K pathway
- Author(s)
  Shingo Nakahata1, Tomonaga Ichikawa1, Yasuhito Arai2, Tomohiko Taki3, Masafumi Taniwaki3,4, Kazuhiro Morishita1
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] ATLやその他のがんにおけるNDRG2発現低下はPTENリン酸化異常を来たし、PI3K/AKT経路を活性化させる。
- Author(s)
  中畑新吾、市川朝永、斎藤祐介、滝智彦、谷脇雅史、森下和広
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25430113
[Presentation] 血中可溶型CADM1/TSLC1測定によるATL診断法の開発.
- Author(s)
  中武彩子、小林行治、西片一朗、中畑新吾、岩永正子、相良康子、北中明、天野正宏、前田宏一、末岡榮三朗、瀬戸口充、岡山昭彦、宇都宮與、下田和哉、渡邊俊樹、森下和広
- Organizer
  HTLV-1研究会・シンポジウム
- Place of Presentation
  港区　東京大学医科学研究所
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] NDRG2は成人T細胞白血病リンパ腫においてがん抑制遺伝子として働く
- Author(s)
  中畑新吾
- Organizer
  第4回HTLV-1研究会・合同斑会議
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-23701061
[Presentation] ATL細胞におけるCADM1高発現はHTLV-1 Taxを含むNF-κB活性化に依存する.
- Author(s)
  西片一朗、市川朝永、中畑新吾、藤井雅寛、伊波英克、白神俊幸、田中勇悦、森下和広
- Organizer
  ６回HTLV-1研究会・シンポジウム.
- Place of Presentation
  港区　東京大学医科学研究所
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] PTENリン酸化異常に伴う白血病、癌発症機構
- Author(s)
  森下和広、中畑新吾、市川朝永
- Organizer
  第87回日本生化学会大会　京都
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-16 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] PI3K系のフィードバックループにおけるNDRG2 Ser332のリン酸化は、PTEN脱リン酸化を誘導するPP2Aリクルートメントに必須である。
- Author(s)
  中畑新吾、市川朝永、新井康仁、滝智彦、谷脇雅史、森下和広
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25430113
[Presentation] PI3Kシグナルによるエンドサイトーシス制御に関与する分子の探索
- Author(s)
  中畑新吾、市川朝永、新井康仁、滝智彦、谷脇雅史、森下和広
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] NDRG2はPPA2と共にHTLV-1感染による活性化PI3K/AKTとNF-ｋB情報伝達を阻害する
- Author(s)
  森下和広、中畑新吾、市川朝永
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] ATLにおける新規PTENキナーゼの同定と機能解析（
- Author(s)
  市川朝永、中畑新吾、森下和広
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2014-08-23 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] 血中可溶性CADM1/TSLC1測定によるATL診断法の開発
- Author(s)
  中武彩子、小林行治、中畑新吾、西片一朗、岩永正子、相良康子、北中明、天野正宏、前田宏一、末岡栄三朗、瀬戸山充、岡山昭彦、宇都宮與、下田和哉、渡邊俊樹、森下和広
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2014-08-23 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25293081
[Presentation] PI3K活性化はNDRG2リン酸化を促進させ、PTENの抑制的リン酸化の解除を誘導する。
- Author(s)
  中畑新吾、市川朝永、斎藤祐介、新井康仁、滝智彦、谷脇雅史、森下和広
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25430113

1. MORISHITA Kazuhiro (80260321)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. ICHIKAWA Tomonaga (80586230)

# of Collaborated Projects: 4 results

# of Collaborated Products: 76 results
3. NISHIKATA Ichiro (50253844)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. TANIWAKI Masafumi (80163640)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
5. 山川哲生 (60335825)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. KANEDA Kazuko (00533209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Kamata Tohru (40056304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Tani Chikako (60817047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 中尾和貴 (20217657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 尾野雅哉 (00270900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
11. 鈴木穣 (40323646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 金子政時 (40264387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 藤井良宜 (10218985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森下和弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 111 results
15. 堀井明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 岩永正子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 渡辺俊樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 水野憲一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAHATA Shingo 中畑 新吾

NAKAHATA Singo 中畑 新吾

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Study on immune evasion strategy and mechanism of the promotion of carcinogenesis of HTLV-1-infected cellsPrincipal Investigator

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Elucidation of the mechanism of adult T-cell leukemia (ATL) development based on gut microbiota analysisPrincipal Investigator

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Analysis of the mechanism of hypoxia stress response in adult t-cell leukemia (ATL)Principal Investigator

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Elucidation of the molecular mechanism involved in dysregulation of PTEN phosphorylation and its physiological role in cancersPrincipal Investigator

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NDRG2 inactivation and PI3K/Akt pathway activation in cancersPrincipal Investigator

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NAKAHATA Shingo 中畑新吾

NAKAHATA Singo 中畑新吾