MIZUTANI Eiji 水谷英二

Researcher Number	80443034
Other IDs
Affiliation (Current)	2019: 東京大学, 医科学研究所, 特任准教授
Affiliation (based on the past Project Information) *help	2015 – 2017: 東京大学, 医科学研究所, 特任研究員 2014 – 2015: 山梨大学, 総合研究部, 助教 2012 – 2013: 山梨大学, 医学工学総合研究部, 助教 2008: The Institute of Physical and Chemical Research, ゲノム・リプログラミング研究チーム, 研究員 2007: The Institute of Physical and Chemical Research, ゲノム・リプログラミング研究チーム, 研究員
Review Section/Research Field	Principal Investigator Applied animal science / Integrative animal science Except Principal Investigator Applied animal science / Integrative animal science
Keywords	Principal Investigator 核移植 / 発生工学 / クローン / 初期胚発生 / ライブセルイメージング / イメージング / 胚性幹細胞 / 初期化 / 加齢 / 生殖細胞 … More Except Principal Investigator クローン / 核移植 / 絶滅動物 / 染色体 / 絶滅危惧種 / 発生工学 / 卵子 / 精子 / 核移植絶滅動物 Less

Feasibility Study for the generation of live cell from extinct or endangered animal
- Principal Investigator
  
  若山照彦
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Integrative animal science
- Research Institution
  University of Yamanashi
Analysis of individual chromosome dynamics in living embryo and establishment of next generation embryo manipulation technique by chromosome transferPrincipal Investigator
- Principal Investigator
  
  MIZUTANI EIJI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  The University of Tokyo
Searching for prerequisites for full term development of cloned embryos based on the live cell imaging analysisPrincipal Investigator
- Principal Investigator
  
  MIZUTANI Eiji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied animal science
- Research Institution
  University of Yamanashi
Feasibility Study for the generation of live cell from extinct or endangered animal
- Principal Investigator
  
  WAKAYAMA Teruhiko
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  University of Yamanashi
  The Institute of Physical and Chemical Research
The effect of donor cell characteristic to the ability of nuclear transfer embryonic stem cell lines.Principal Investigator
- Principal Investigator
  
  MIZUTANI Eiji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied animal science
- Research Institution
  The Institute of Physical and Chemical Research

All 2017 2016 2015 2014 2013 2012 2008 2007

All Journal Article Presentation Book

[Book] Treatment of donor cell/embryo with different approaches to improve development after nuclear transfer.2015
- Author(s)
  Mizutani E, Wakayama S, Wakayama T.
- Publisher
  Methods Mol Biol.
- Data Source
  KAKENHI-PROJECT-23248048
[Book] Nuclear transfer in the mouse oocyte.2013
- Author(s)
  Mizutani E, Ogura A, Wakayama T.
- Publisher
  Methods Mol Biol.
- Data Source
  KAKENHI-PROJECT-23248048
[Book] Cloning of Mice In “Principles of Cloning Second edition”. (Ed. Cibelli J. Gurdon J. Wilmut I. Jaenisch R. Lanza R. West MD. Campbell KHS)2013
- Author(s)
  Mizutani, E. Kishigami S. and Wakayama T.
- Publisher
  Academic press, San Diego, USA,
- Data Source
  KAKENHI-PROJECT-23248048
[Book] Nuclear transfer in the mouse oocyte In "Mammalian Oocyte Regulation" Ed. by Hayden Homer2013
- Author(s)
  Mizutani E. Ogura A. and Wakayama T.
- Publisher
  Humana press, USA
- Data Source
  KAKENHI-PROJECT-23248048
[Journal Article] The Number of Point Mutations in Induced Pluripotent Stem Cells and Nuclear Transfer Embryonic Stem Cells Depends on the Method and Somatic Cell Type Used for Their Generation.2017
- Author(s)
  Araki R, Mizutani E, Hoki Y, Sunayama M, Wakayama S, Nagatomo H, Kasama Y, Nakamura M, Wakayama T, Abe M.
- Journal Title
  
  Stem Cells
  
  Volume: 35 Pages: 1189-1196
- DOI
  10.1002/stem.2601
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H02593, KAKENHI-PROJECT-26506006, KAKENHI-PROJECT-17K15359
[Journal Article] Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months.2017
- Author(s)
  Sayaka Wakayama, Yuko Kamada, Kaori Yamanaka, Takashi Kohda, Hiromi Suzuki, Toru Shimazu,
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 1 Pages: 201701425-201701425
- DOI
  10.1073/pnas.1701425114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26506032, KAKENHI-PROJECT-17K15359, KAKENHI-PROJECT-16J07536, KAKENHI-PROJECT-16H02478, KAKENHI-PROJECT-16H02593
[Journal Article] Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation.2017
- Author(s)
  Yagi M, Kishigami S, Tanaka A, Semi K, Mizutani E, Wakayama S, Wakayama T, Yamamoto T, Yamada Y.
- Journal Title
  
  Nature
  
  Volume: 548 Pages: 224-227
- DOI
  10.1038/nature23286
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02593, KAKENHI-PROJECT-15H04605, KAKENHI-PROJECT-15H04721, KAKENHI-PROJECT-15J05792
[Journal Article] Agarose capsules as new tools for protecting denuded mouse oocytes/embryos during handling and freezing-thawing and supporting embryonic development in vivo2017
- Author(s)
  Nagatomo H, Yao T, Araki Y, Mizutani E, Wakayama T.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 17960-17960
- DOI
  10.1038/s41598-017-18365-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15359, KAKENHI-PROJECT-16H02593, KAKENHI-PROJECT-15H04605
[Journal Article] Effect of Long-Term Exposure of Donor Nuclei to the Oocyte Cytoplasm on Production of Cloned Mice Using Serial Nuclear Transfer.2016
- Author(s)
  Wakayama S, Tanabe Y, Nagatomo H, Mizutani E, Kishigami S, Wakayama T.
- Journal Title
  
  Cell Reprogramming
  
  Volume: 18 Pages: 382-389
- DOI
  10.1089/cell.2016.0026
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H02593, KAKENHI-PROJECT-26506006
[Journal Article] Generation of cloned mice and nuclear transfer embrionic stem cell lines from urine-derived cells2016
- Author(s)
  Mizutani E, Torikai K, Wakayama S, Nagatomo H, Ohinata Y, Kishigami S, Wakayama T.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 23808-23808
- DOI
  10.1038/srep23808
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23248048, KAKENHI-PROJECT-16H02593, KAKENHI-PROJECT-15H04605, KAKENHI-PROJECT-25712030, KAKENHI-PROJECT-26506006
[Journal Article] Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly.2015
- Author(s)
  Ishiuchi T, Enriquez-Gasca R, Mizutani E, Boskovic A, Ziegler-Birling C, Rodriguez-Terrones D, Wakayama T, Vaquerizas JM, Torres-Padilla ME
- Journal Title
  
  Nature Struct Mol Biol.
  
  Volume: 22 Pages: 662-671
- DOI
  10.1038/nsmb.3066
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23248048
[Journal Article] Generation of cloned mice from adult neurons by direct nuclear transfer.2015
- Author(s)
  Mizutani E, Oikawa M, Kassai H, Inoue K, Shiura H, Hirasawa R, Kamimura S, Matoba S, Ogonuki N, Nagatomo H, Abe K, Wakayama T, Aiba A, Ogura A.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 92(3) 81 Pages: 1-11
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24780277
[Journal Article] Generation of Cloned Mice from Adult Neurons by Direct Nuclear Transfer.2015
- Author(s)
  Mizutani E, Oikawa M, Kassai H, Inoue K, Shiura H, Hirasawa R, Kamimura S, Matoba S, Ogonuki N, Nagatomo H, Abe K, Wakayama T, Aiba A, Ogura A.
- Journal Title
  
  Biol Reprod.
  
  Volume: 92 Pages: 81-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23248048
[Journal Article] RNA sequencing-based identification of aberrant imprinting in cloned mice2014
- Author(s)
  Okae H, Matoba S, Nagashima T, Mizutani E, Inoue K, Ogonuki N, Chiba H, Funayama R, Tanaka S, Yaegashi N, Nakayama K, Sasaki H, Ogura A, Arima T.
- Journal Title
  
  Hum. Mol. Genet.,
  
  Volume: 23 Pages: 992-1001
- DOI
  10.1093/hmg/ddt495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390385, KAKENHI-PROJECT-23500507, KAKENHI-PUBLICLY-24116503, KAKENHI-PROJECT-24700951, KAKENHI-PROJECT-24780277, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112009, KAKENHI-PLANNED-25112010
[Journal Article] Successful serial recloning in the mouse over multiple generations2013
- Author(s)
  Wakayama S, Kohda T, Obokata H, Tokoro M, Li C, Terashita Y, Mizutani E, Nguyen VT, Kishigami S, Ishino F, Wakayama T.
- Journal Title
  
  Cell Stem Cell.
  
  Volume: 12 Pages: 293-297
- DOI
  10.1016/j.stem.2013.01.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07319, KAKENHI-PLANNED-20062015, KAKENHI-PROJECT-21688020, KAKENHI-PROJECT-23221010, KAKENHI-PROJECT-23248048, KAKENHI-PROJECT-23580416, KAKENHI-PROJECT-24780277, KAKENHI-ORGANIZER-25112001
[Journal Article] Fluorescence cell imaging and manipulation using conventional halogen lamp microscopy2012
- Author(s)
  Mizutani E, et al.
- Journal Title
  
  Dev Biol.
  
  Volume: (in press) Pages: 56-65
- DOI
  10.1016/j.ydbio.2012.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062015, KAKENHI-PROJECT-22650096, KAKENHI-PROJECT-23248048
[Journal Article] Therapeutic cloning in individual parkinsonian mice.2008
- Author(s)
  Tabar V.、水谷英二(11名中7番目)
- Journal Title
  
  Nature Medicine 14巻4号
  
  Pages: 379-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780213
[Journal Article] Nuclear transfer preserves the nuclear genome of freeze-dried mouse cells.2008
- Author(s)
  小野哲男、水谷英二、李羽中、若山照彦
- Journal Title
  
  The Journal of Reproduction and Development 54巻6号
  
  Pages: 486-91
- NAID
  10024940504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780213
[Journal Article] Production of healthy cloned mice from bodies frozen at -20 degrees C for 16 years.2008
- Author(s)
  若山清香、水谷英二(7名中4番目)
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America 105巻45号
  
  Pages: 17318-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780213
[Journal Article] Propagation of senescent mice using nuclear transfer embryonic stem cell lines.2008
- Author(s)
  水谷英二、小野哲男、李羽中、牧-、末次里奈子、若山照彦
- Journal Title
  
  Genesis 46巻9号
  
  Pages: 478-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780213
[Journal Article] Propagation of senescent mice using nuclear transfer embryonic stem cell lines2008
- Author(s)
  Mizutani E
- Journal Title
  
  Genesis 46巻9号
  
  Pages: 478-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780213
[Journal Article] Spindle formation and microtubule organization during first division in reconstructed rat embryos produced by somatic cell nuclear transfer.2007
- Author(s)
  富岡郁夫、水谷英二(7名中2番目)
- Journal Title
  
  Journal of Reproduction and Development 53巻4号
  
  Pages: 835-842
- NAID
  10020003952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780213
[Journal Article] Efficient establishment of mouse embryonic stem cell lines from single blastomeres and polar bodies2007
- Author(s)
  若山清香、水谷英二(7名中6番目)
- Journal Title
  
  Stem Cells 25巻4号
  
  Pages: 986-993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780213
[Presentation] ラット卵細胞質内精子注入法の簡便化の試み2017
- Author(s)
  水谷英二、加藤めぐみ、笠井真理子、中内啓光
- Organizer
  第40回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H04605
[Presentation] マウス2細胞期胚において分配異常を起こした染色体の回収と同定の試み2016
- Author(s)
  柴﨑郁江、鎌田裕子、鳥飼昂平、長友啓明、水谷英二、若山照彦
- Organizer
  109回日本繁殖生物学会
- Place of Presentation
  麻布大学神奈川県
- Year and Date
  2016-09-12
- Data Source
  KAKENHI-PROJECT-16H02593
[Presentation] マウスクローン胚のライブセルイメージングと単一胚移植による解析2013
- Author(s)
  水谷英二、山縣一夫、若山照彦
- Organizer
  第54回日本卵子学会
- Place of Presentation
  学術総合センター (東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24780277
[Presentation] マウスクローン胚のライブセルイメージングと単一胚移植による解析2013
- Author(s)
  水谷英二、山縣一夫、若山照彦
- Organizer
  題54回　日本卵子学会
- Place of Presentation
  東京都　学術総合センター
- Data Source
  KAKENHI-PROJECT-24780277
[Presentation] Live-cell imaging analysis of mouse oocytes injected with freeze-dried spermatozoa.2013
- Author(s)
  水谷英二、若山清香、岸田佳奈、若山照彦
- Organizer
  第10回Annual Conference of Asian Reproductive Biotechnology Society
- Place of Presentation
  ベトナム　ムイネ　シーリンクビーチリゾート
- Data Source
  KAKENHI-PROJECT-24780277
[Presentation] 凍結乾燥精子で受精したマウス初期胚のライブセルイメージング解析2013
- Author(s)
  水谷英二、若山清香、岸田佳奈、若山照彦
- Organizer
  第106回日本繁殖生物学会大会
- Place of Presentation
  東京農工大学農学部府中キャンパス
- Data Source
  KAKENHI-PROJECT-24780277
[Presentation] GENERATION OF CLONED MICE BY DIRECT NUCLEAR TRANSFER FROM ADULT DIFFERENTIATED NEURAL CELLS2012
- Author(s)
  Mizutani E., Kassai H., Wakayama T., Aiba A., Ogura A.
- Organizer
  9th Asian Reproductive Biotechnology Society
- Place of Presentation
  フィリピン　マニラ
- Data Source
  KAKENHI-PROJECT-24780277
[Presentation] 成体マウス脳神経細胞からのクローンマウス作出2012
- Author(s)
  水谷英二、葛西秀俊、若山照彦、饗場篤、小倉淳郎
- Organizer
  第105回　日本繁殖生物学会
- Place of Presentation
  つくば市　筑波大学
- Data Source
  KAKENHI-PROJECT-24780277
[Presentation] ライブセルイメージングによるマウス体細胞クローン胚の解析およびクローン産仔の作出2008
- Author(s)
  水谷英二
- Organizer
  第101 日本繁殖生物学会
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19780213
[Presentation] Retrospective and correlation analysis of the cloned embryos using long-term, six dimensional live-cell imaging2008
- Author(s)
  水谷英二
- Organizer
  5^<th> Asian Reproductive Biotechnology Society
- Place of Presentation
  Kunming, Yunnan, China
- Data Source
  KAKENHI-PROJECT-19780213
[Presentation] Successfully producing cloned mice from somatic cells of aged mice via established ntES cell lines.2008
- Author(s)
  水谷英二
- Organizer
  34^<th> International Embryo Transfer Society
- Place of Presentation
  Denver, Colorado, USA
- Data Source
  KAKENHI-PROJECT-19780213
[Presentation] Successfully producing cloned mice from somatic cells of aged mice viaestablished ntES cell lines.2008
- Author(s)
  Eiji Mizutani
- Organizer
  34th International Embryo Transfer Society
- Place of Presentation
  Denver, Colorado, USA
- Data Source
  KAKENHI-PROJECT-19780213
[Presentation] Retrospective and correlation analysis of the cloned embryos using lone-term, six dimensional live-cell imaging2008
- Author(s)
  Mizutani E
- Organizer
  5^<th> Asian Eeproductive Biotechnology Society
- Place of Presentation
  Kunming, Yunnan, China
- Data Source
  KAKENHI-PROJECT-19780213
[Presentation] 高齢マウス体細胞からの胚性幹細胞の樹立と体細胞クローン個体作出2007
- Author(s)
  水谷英二
- Organizer
  第100回日本繁殖生物学会
- Place of Presentation
  東京大学農学部
- Year and Date
  2007-10-20
- Data Source
  KAKENHI-PROJECT-19780213
[Presentation] Successfully producing cloned mice from somatic cells of aged mice viaestablished ntES cell lines.2007
- Author(s)
  Eiji Mizutani
- Organizer
  4th Asian Reproductive Biotechnology Society
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-19780213
[Presentation] Successfully producing cloned mice from somatic cells of aged mice via established ntES cell lines.2007
- Author(s)
  水谷英二
- Organizer
  4^<th> Asian Reproductive Biotechnology Society
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-19780213

1. WAKAYAMA Teruhiko (40360672)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. 長友啓明 (30746813)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 岸上哲士 (10291064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 大我政敏 (40644886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 若山清香

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
6. 幸田尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 有馬隆博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 岡江寛明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 八重樫伸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 越後貫成美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 長嶋剛史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 舟山亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小倉淳郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 佐々木裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 大日向康秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 石野史敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 石野知子(金児知子)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 山田泰広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 山縣一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIZUTANI Eiji 水谷 英二

Research Projects

Research Products

Co-Researchers

Feasibility Study for the generation of live cell from extinct or endangered animal

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of individual chromosome dynamics in living embryo and establishment of next generation embryo manipulation technique by chromosome transferPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Searching for prerequisites for full term development of cloned embryos based on the live cell imaging analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Feasibility Study for the generation of live cell from extinct or endangered animal

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of donor cell characteristic to the ability of nuclear transfer embryonic stem cell lines.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Treatment of donor cell/embryo with different approaches to improve development after nuclear transfer.2015

Author(s)

Publisher

Data Source

[Book] Nuclear transfer in the mouse oocyte.2013

Author(s)

Publisher

Data Source

[Book] Cloning of Mice In “Principles of Cloning Second edition”. (Ed. Cibelli J. Gurdon J. Wilmut I. Jaenisch R. Lanza R. West MD. Campbell KHS)2013

Author(s)

Publisher

Data Source

[Book] Nuclear transfer in the mouse oocyte In "Mammalian Oocyte Regulation" Ed. by Hayden Homer2013

Author(s)

Publisher

Data Source

[Journal Article] The Number of Point Mutations in Induced Pluripotent Stem Cells and Nuclear Transfer Embryonic Stem Cells Depends on the Method and Somatic Cell Type Used for Their Generation.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Agarose capsules as new tools for protecting denuded mouse oocytes/embryos during handling and freezing-thawing and supporting embryonic development in vivo2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of Long-Term Exposure of Donor Nuclei to the Oocyte Cytoplasm on Production of Cloned Mice Using Serial Nuclear Transfer.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of cloned mice and nuclear transfer embrionic stem cell lines from urine-derived cells2016

Author(s)

Journal Title

DOI

Data Source

MIZUTANI Eiji 水谷英二