Okamura Toshimitsu 岡村敏充

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OKAMURA Toshimitsu 岡村敏充

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Researcher Number	80443068
Other IDs
Affiliation (Current)	2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所先進核医学基盤研究部, 主任研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所先進核医学基盤研究部, 主任研究員 2021 – 2023: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所先進核医学基盤研究部, 主任研究員 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所先進核医学基盤研究部, 主任研究員(任常) 2019: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所先進核医学基盤研究部, 研究員(任常) 2016 – 2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所標識薬剤開発部, 研究員(任常) … More 2015: 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 2011 – 2014: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 2008 – 2009: National Institute of Radiological Sciences, 分子イメージング研究センター, 研究員 Less
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator PET / 放射性医薬品 / イメージング / PET薬剤 / 心筋 / グリンパティックシステム / 排出システム / 脳 / チオシアン酸イオン / NADPHオキシダーゼ … More / 酸化 / NOX / ＰＥＴ / レドックス / トランスポータ / ＰＥＴ薬剤 / 分子イメージング / プリン / 異物排出トランスポータ / グルタチオン抱合体 Less

心筋における排出トランスポータ活性の定量測定を目的とするPETトレーサの開発Principal Investigator
- Principal Investigator
  
  岡村敏充
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
脳から老廃物を排出するグリンパティックシステムの非侵襲的定量評価法の開発Principal Investigator
- Principal Investigator
  
  岡村敏充
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Development of a noninvasive and quantitative method for measuring the efflux rate of thiocyanate from the brain and elucidation of its efflux mechanismPrincipal Investigator
- Principal Investigator
  
  OKAMURA Toshimitsu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Development of PET tracers for measuring the activity of NADPH oxidase in the brainPrincipal Investigator
- Principal Investigator
  
  Okamura Toshimitsu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of PET probes for imaging of redox status in the brainPrincipal Investigator
- Principal Investigator
  
  Okamura Toshimitsu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
Imaging of the function of efflux transporters in peripheral tissuesPrincipal Investigator
- Principal Investigator
  
  OKAMURA Toshimitsu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
Development of probes and methods for noninvasive and quantitative assessment of efflux systems in the brainPrincipal Investigator
- Principal Investigator
  
  OKAMURA Toshimitsu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences

[Book] PET and SPECT of Neurobiological Systems2020
- Author(s)
  Toshimitsu Okamura, Tatsuya Kikuchi, and Ming-Rong Zhang
- Total Pages
  1144
- Publisher
  Springer
- ISBN
  9783030531751
- Data Source
  KAKENHI-PROJECT-19K08241
[Journal Article] Improved synthesis of 6-bromo-7-[11C]methylpurine for clinical use2024
- Author(s)
  Okamura Toshimitsu、Kikuchi Tatsuya、Ogawa Masanao、Zhang Ming-Rong
- Journal Title
  
  EJNMMI Radiopharmacy and Chemistry
  
  Volume: 9 Issue: 1
- DOI
  10.1186/s41181-024-00240-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07785
[Journal Article] 11C-Labeled Radiotracer for Noninvasive and Quantitative Assessment of the Thiocyanate Efflux System in the Brain2022
- Author(s)
  Okamura Toshimitsu、Tsukamoto Satoshi、Okada Maki、Kikuchi Tatsuya、Aizawa Ryutaro、Wakizaka Hidekatsu、Nengaki Nobuki、Ogawa Masanao、Ishii Hideki、Zhang Ming-Rong
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 33 Issue: 9 Pages: 1654-1662
- DOI
  10.1021/acs.bioconjchem.2c00277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03635, KAKENHI-PROJECT-19K08241
[Journal Article] Kinetics and metabolism of apocynin in the mouse brain assessed with positron-emission tomography2018
- Author(s)
  Okamura Toshimitsu、Okada Maki、Kikuchi Tatsuya、Wakizaka Hidekatsu、Zhang Ming-Rong
- Journal Title
  
  Phytomedicine
  
  Volume: 38 Pages: 84-89
- DOI
  10.1016/j.phymed.2017.05.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10302
[Journal Article] A 11C-labeled 1,4-dihydroquinoline derivative as a potential PET tracer for imaging of redox status in mouse brain2015
- Author(s)
  Okamura Toshimitsu, Okada Maki, Kikuchi Tatsuya, Wakizaka Hidekatsu, Zhang Ming-Rong
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 35 Issue: 12 Pages: 1930-1936
- DOI
  10.1038/jcbfm.2015.132
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461895
[Journal Article] Imaging of Activity of Multidrug Resistance-Associated Protein 1 in the Lungs2013
- Author(s)
  Toshimitsu Okamura, Tatsuya Kikuchi, Maki Okada, Hidekatsu Wakizaka, and Ming-Rong Zhang
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: (in press) Issue: 3 Pages: 335-340
- DOI
  10.1165/rcmb.2012-0275ma
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791468
[Journal Article] Reactivity of 6-Halopurine Analogs with Glutathione as a Radiotracer for Assessing Function of Multidrug Resistance-Associated Protein 12009
- Author(s)
  Okamura, T.;Kikuchi, T.;Fukushi, K.; Irie, T.
- Journal Title
  
  J Med Chem 52
  
  Pages: 7284-7288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790920
[Journal Article] Noninvasive and quantitative assessment of the function of multidrug resistance-associated protein 1 in the living brain2009
- Author(s)
  Toshimitsu Okamura
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism 29
  
  Pages: 504-511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790920
[Journal Article] Reactivity of 6-Halopurine Analogs with Glutathione as a Radiotracer for Assessing Function of Multidrug Resistance-Associated Protein 12009
- Author(s)
  Toshimitsu Okamura
- Journal Title
  
  Journal of medicinal chemistry 52
  
  Pages: 7284-7288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790920
[Journal Article] Noninvasive and quantitative assessment of the function of multidrug resistance-associated protein 1 in the living brain2009
- Author(s)
  Okamura, T.;Kikuchi, T.;Okada, M.; Toramatsu, C.; Fukushi, K.;Takei, M.; Irie, T.
- Journal Title
  
  J Cereb Blood Flow Metab 29
  
  Pages: 504-511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790920
[Presentation] Effects of solvents on the yield of 6-bromo-7-[11C]methylpurine2023
- Author(s)
  Toshimitsu Okamura, Tatsuya Kikuchi, Ming-Rong Zhang
- Organizer
  25th International Symposium on Radiopharmaceutical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07785
[Presentation] 脳内のNIS活性イメージングプローブの開発2022
- Author(s)
  岡村敏充, 塚本智史, 岡田真希, 菊池達矢, 相澤竜太郎, 脇坂秀克, 念垣信樹, 小川政直, 石井英樹, 張明栄
- Organizer
  第62回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08241
[Presentation] チオシアネート排出系を定量評価するためのPETトレーサの開発2021
- Author(s)
  岡村敏充、岡田真希、脇坂秀克、菊池達矢、張明栄
- Organizer
  第61回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08241
[Presentation] 脳内のチオシアン酸イオンの排出システムを定量評価するためのプローブの開発2020
- Author(s)
  岡村敏充、小川政直、菊池達矢、張明栄
- Organizer
  第60回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08241
[Presentation] 脳内NADPHオキシダーゼ活性イメージングプローブの開発2018
- Author(s)
  岡村敏充 , 岡田真希 , 菊池達矢 , 脇坂秀克 , 張明栄
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K10302
[Presentation] Evaluation of kinetics of acetovanillone in the brain by PET2017
- Author(s)
  Toshimitsu Okamura, Maki Okada, Tatsuya Kikuchi, Hidekatsu Wakizaka, Ming-Rong Zhang
- Organizer
  22nd International symposium on radiopharmaceutical science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10302
[Presentation] アポシニンの脳内動態の評価および代謝物分析2016
- Author(s)
  岡村敏充, 岡田真希, 脇坂秀克, 菊池達矢, 張明栄
- Organizer
  第56回日本核医学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-16K10302
[Presentation] Development of a Tracer for Imaging Activity of NADPH oxidase in the Brain2014
- Author(s)
  Okamura T, Okada M, Wakizaka H, and Zhang MR
- Organizer
  First Adriatic Symposium on Biophysical Approaches in Biomedical Studies
- Place of Presentation
  Split
- Year and Date
  2014-08-25
- Data Source
  KAKENHI-PROJECT-25461895
[Presentation] 酸化還元状態イメージング用分子プローブの開発2014
- Author(s)
  岡村敏充, 岡田真希, 脇坂秀克, 菊池達矢, 張明栄
- Organizer
  第54回日本核医学会学術総会
- Place of Presentation
  大阪市
- Year and Date
  2014-11-06
- Data Source
  KAKENHI-PROJECT-25461895
[Presentation] 肺組織における薬剤排出トランスポータ機能測定用分子プローブの開発研究2012
- Author(s)
  岡村敏充、菊池達矢、岡田真希、張明栄、脇坂秀克
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学札幌キャンパス、札幌市
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-23791468
[Presentation] Evaluation of a purine derivative for imaging of the efflux transporter (ABCC1) in the lung2011
- Author(s)
  Okamura, Toshimitsu
- Organizer
  19th International Symposium on Radiopharmaceutical Sciences
- Place of Presentation
  アムステルダム
- Data Source
  KAKENHI-PROJECT-23791468
[Presentation] 肺における異物排出ポンプ機能の測定を目的とするPETプローブの開発2011
- Author(s)
  岡村　敏充
- Organizer
  第51回日本核医学会学術総会
- Place of Presentation
  つくば市
- Data Source
  KAKENHI-PROJECT-23791468
[Presentation] 肺における異物排出ポンプ機能の測定を目的とするPETプローブの開発2011
- Author(s)
  岡村敏充、菊池達矢, 岡田真希, 張明栄, 脇坂秀克
- Organizer
  第51回日本核医学会学術総会
- Place of Presentation
  つくば国際会議場、つくば市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23791468
[Presentation] Evaluation of a purine derivative for imaging of the efflux transporter (ABCC1) in the lung2011
- Author(s)
  Toshimitsu Okamura, Tatsuya Kikuchi, Maki Okada, Hidekatsu Wakizaka
- Organizer
  the 19th International Symposium on Radiopharmaceutical Sciences
- Place of Presentation
  VU University Medical Center, Amsterdam, the Netherlands
- Year and Date
  2011-08-28
- Data Source
  KAKENHI-PROJECT-23791468
[Presentation] Evaluation of the conversion rate of 6-halogenopurine derivatives as a probe for assessing mrpl function2009
- Author(s)
  Okamura, T., et, al.
- Organizer
  18th International Symposium on Radiopharmaceutical Sciences
- Place of Presentation
  Shaw Conference Centre, Edmonton
- Year and Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-20790920
[Presentation] Evaluation of the conversion rate of 6-halogenopurine derivatives as a probe for assessing mrpl function2009
- Author(s)
  Toshimitsu Okamura
- Organizer
  18th International Symposium on Radiopharmaceutical Sciences
- Place of Presentation
  カナダエドモントン
- Year and Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-20790920
[Presentation] 6-Bromo-7-[11C]- methylpurine is a Specific Probe for the ABC Transporter Mrp1, but not for Mrp2, Pgp, and Bcrp2009
- Author(s)
  Okamura, T., et, al.
- Organizer
  Annual Congress of the European Association of Nuclear Medicine
- Place of Presentation
  Barcelona International Convention Center, Barcelona.
- Year and Date
  2009-10-13
- Data Source
  KAKENHI-PROJECT-20790920
[Presentation] A PET Probe for Quantitatively Assessing the Efflux Transport Function of Multidrug Resistance-Associated Protein 1 in the Brain2008
- Author(s)
  Okamura, T., et, al.
- Organizer
  World Molecular Imaging Congress
- Place of Presentation
  The Acropolis Convention Center, Nice
- Year and Date
  2008-09-13
- Data Source
  KAKENHI-PROJECT-20790920
[Presentation] A PET Probe for Quantitatively Assessing the Efflux Transport Function of Multidrug Resistance-Associated Protein 1 in the Brain2008
- Author(s)
  Toshimitsu Okamura
- Organizer
  World Molecular Imaging Congress (WMIC)
- Place of Presentation
  仏蘭西ニース
- Year and Date
  2008-09-13
- Data Source
  KAKENHI-PROJECT-20790920

1. ZHANG Ming-Rong

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okamura Toshimitsu 岡村 敏充

OKAMURA Toshimitsu 岡村 敏充

Research Projects

Research Products

Co-Researchers

心筋における排出トランスポータ活性の定量測定を目的とするPETトレーサの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳から老廃物を排出するグリンパティックシステムの非侵襲的定量評価法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a noninvasive and quantitative method for measuring the efflux rate of thiocyanate from the brain and elucidation of its efflux mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of PET tracers for measuring the activity of NADPH oxidase in the brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of PET probes for imaging of redox status in the brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Imaging of the function of efflux transporters in peripheral tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of probes and methods for noninvasive and quantitative assessment of efflux systems in the brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] PET and SPECT of Neurobiological Systems2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Improved synthesis of 6-bromo-7-[11C]methylpurine for clinical use2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 11C-Labeled Radiotracer for Noninvasive and Quantitative Assessment of the Thiocyanate Efflux System in the Brain2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kinetics and metabolism of apocynin in the mouse brain assessed with positron-emission tomography2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A 11C-labeled 1,4-dihydroquinoline derivative as a potential PET tracer for imaging of redox status in mouse brain2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Imaging of Activity of Multidrug Resistance-Associated Protein 1 in the Lungs2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reactivity of 6-Halopurine Analogs with Glutathione as a Radiotracer for Assessing Function of Multidrug Resistance-Associated Protein 12009

Author(s)

Okamura Toshimitsu 岡村敏充

OKAMURA Toshimitsu 岡村敏充