YAMASHITA Tetsuo 山下哲生

… Alternative Names

山下哲生ヤマシタテツオ

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Researcher Number	80444727
Other IDs
Affiliation (Current)	2025: 香川大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 香川大学, 医学部, 助教 2011 – 2017: 香川大学, 医学部, 助教 2007 – 2008: Kagawa University, 医学部, 助教
Review Section/Research Field	Principal Investigator Functional biochemistry Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / General physiology / Medical pharmacy
Keywords	Principal Investigator フラボプロテイン / 基質結合部位 / ユビキノン / 反応機構 / 電子伝達系 / ミトコンドリア / 結晶構造解析 / 薬剤標的分子 / 酵素の触媒機構 / 阻害剤 … More / 共結晶 / X線結晶構造解析 / ユビキノン結合部位 / NADH dehydrogenase / 国際情報交換 / エネルギー代謝 / NADH脱水素酵素 / 活性酸素 / 国際情報交換(アメリカ) / 酸化還元酵素 / キノン還元反応 / 酵素 … More Except Principal Investigator カルシウム / 細胞間接着 / 血管内皮細胞 / RNA干渉法 / マイクロアレイ解析 / インスリン分解酵素 / 貯蔵部作動性カルシウム流入 / 遺伝子発現 / プロテイナーゼ活性化型受容体１ / 老化 / インスリン抵抗性 / 受容体 / 凝固因子 / 廊下 / 腸内細菌 / プレバイオティクス / probiotics / breastfeeding / colorectal cancer / IBD / ミルクオリゴ糖 / 炎症性発癌 / プロバイオティクス / 炎症性腸疾患 / 母乳 / AIF / ＡＩＦ / 分子機序 / 膜結合様式 / カスパーゼ非依存性細胞死 / ミトコンドリア / 細胞死 / アシルグルクロナイド / siRNA / 反応性代謝物 / 代謝酵素 / トランスポーター / 肝毒性 / 薬物動態・代謝学 Less

Elucidation and regulation of the senescence-accelerating function of coagulation system
- Principal Investigator
  
  平野勝也
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kagawa University
New therapeutic strategy for inflammatory bowel disease and inflammatory carcinogenesis from breast milk-derived probiotics
- Principal Investigator
  
  Kurahara Lin
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kagawa University
Study on the reaction mechanism of type II NADH dehydrogenase by structural and biochemical analyses of the enzyme-inhibitor interaction.Principal Investigator
- Principal Investigator
  
  Yamashita Tetsuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagawa University
The structural insight into ROS suppression mechanism of type II NADH dehydrogenase (NDH-2)Principal Investigator
- Principal Investigator
  
  YAMASHITA Tetsuo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagawa University
Involvement of metabolic enzymes and transporters in diclofenac-induced liver injury
- Principal Investigator
  
  IWAKI Masahiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kinki University
Induction mechanism of AIF-related cell death
- Principal Investigator
  
  KOSAKA Hiroaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kagawa University
Analysis of ubiquinone reduction mechanism of mitochondrial single-subunit NADH quinone oxidoreductasePrincipal Investigator
- Principal Investigator
  
  YAMASHITA Tetsuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagawa University

All 2024 2023 2022 2021 2018 2015 2014 2012 2011 2007 Other

All Journal Article Presentation

[Journal Article] Therapeutic Effect of Proteinase-Activated Receptor-1 Antagonist on Colitis-Associated Carcinogenesis2024
- Author(s)
  Li Xiaodong、Kurahara Lin-Hai、Zhao Zhixin、Zhao Feiyan、Ishikawa Ryo、Ohmichi Kiyomi、Li Gaopeng、Yamashita Tetsuo、Hashimoto Takeshi、Hirano Mayumi、Sun Zhihong、Hirano Katsuya
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: XXX Issue: 1 Pages: 105-131
- DOI
  10.1016/j.jcmgh.2024.04.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11699
[Journal Article] Lactulose modulates the structure of gut microbiota and alleviates colitis-associated tumorigenesis2022
- Author(s)
  1.Hiraishi K, Zhao F, Kurahara LH*, Li X, Yamashita T, Hashimoto T, Matsuda Y, Sun Z, Zhang H, Hirano K
- Journal Title
  
  Nutrients
  
  Volume: 14(3) Issue: 3 Pages: 649-649
- DOI
  10.3390/nu14030649
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11699
[Journal Article] Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors2018
- Author(s)
  Yamashita Tetsuo, Inaoka Daniel Ken, Shiba Tomoo, Oohashi Takumi, Iwata So, Yagi Takao, Kosaka Hiroaki, Miyoshi Hideto, Harada Shigeharu, Kita Kiyoshi, Hirano Katsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2427-2427
- DOI
  10.1038/s41598-018-20775-6
- NAID
  120006532084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17420, KAKENHI-PROJECT-15K07005
[Presentation] 腸炎関連発がんに対する希少糖D-アロースの治療効果2023
- Author(s)
  倉原琳、李小東、李高鵬、山下哲生、橋本剛、神鳥和代、平野勝也
- Organizer
  第65回日本平滑筋学会
- Data Source
  KAKENHI-PROJECT-21K11699
[Presentation] 炎症性大腸腫瘍モデルにおける希少糖D-アロースの腫瘍抑制効果2021
- Author(s)
  倉原琳、平石敬三、李小東、山下哲生、橋本剛、平野勝也
- Organizer
  第73回日本生理学会中国四国地方会
- Data Source
  KAKENHI-PROJECT-21K11699
[Presentation] 競合および混合阻害剤との共結晶構造解析により明らかとなった出芽酵母由来Type II NADH脱水素酵素のユビキノン結合部位2018
- Author(s)
  山下哲生，稲岡健ダニエル，志波智生，大橋匠，岩田想，矢木隆雄，三芳秀，原田繁春，北潔，平野勝也
- Organizer
  日本農芸化学会中四国支部第51回講演会
- Data Source
  KAKENHI-PROJECT-15K07005
[Presentation] 出芽酵母由来Type II NADH dehydrogenase (NDH-2)のユビキノン競合阻害剤との高分解能複合体構造解析2015
- Author(s)
  大橋拓未、稲岡ダニエル健、山下哲生、志波智生、岩田想、原田繁春、北潔
- Organizer
  日本生体エネルギー研究会　第41回討論会
- Place of Presentation
  東京大学医学部1号館講堂
- Year and Date
  2015-12-23
- Data Source
  KAKENHI-PROJECT-15K07005
[Presentation] Apoptosis-inducing factor依存的細胞死の制御機構の解析2014
- Author(s)
  山下哲生、橋本剛、五十嵐淳介、平野勝也、小阪博昭
- Organizer
  第55回（平成26年度）日本生化学会中国・四国支部例会
- Place of Presentation
  愛媛大学　城北キャンパス
- Year and Date
  2014-06-07
- Data Source
  KAKENHI-PROJECT-25840036
[Presentation] Apoptosis-inducing factor依存的細胞死の制御機構の解析2014
- Author(s)
  山下哲生、橋本剛、五十嵐淳介、小坂博昭
- Organizer
  第５５回日本生化学会中国四国支部例会
- Place of Presentation
  愛媛大学城北キャンパス
- Data Source
  KAKENHI-PROJECT-23590260
[Presentation] Apoptosis-inducing factor (AIF)の膜への結合様式の解析2014
- Author(s)
  山下哲生、橋本剛、五十嵐淳介、小坂博昭
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学
- Data Source
  KAKENHI-PROJECT-23590260
[Presentation] Apoptosis-inducing factor (AIF)の膜への結合様式の解析2014
- Author(s)
  山下哲生、橋本剛、五十嵐淳介、小坂博昭
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス
- Data Source
  KAKENHI-PROJECT-25840036
[Presentation] 酵母シングルサブユニットＮＡＤＨ-キノン酸化還元酵素における活性酸素の生成抑制機構2012
- Author(s)
  山下　哲生
- Organizer
  第89回日本生理学会
- Place of Presentation
  長野県松本文化会館（長野）
- Data Source
  KAKENHI-PROJECT-23590260
[Presentation] 酵母Type II NADH脱水素酵素（NDH-2）において活性酸素の生成が負に制御される分子機構の解析2011
- Author(s)
  山下　哲生
- Organizer
  日本生体エネルギー研究会　第３７回討論会
- Place of Presentation
  京都産業大学（京都）
- Data Source
  KAKENHI-PROJECT-23590260
[Presentation] 酵母シングルサブユニット・ＮＡＤＨ-キノン酸化還元酵素の反応機構：活性酸素の生成抑制機構の解析2011
- Author(s)
  山下　哲生
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会議場（京都）
- Data Source
  KAKENHI-PROJECT-23590260
[Presentation] 酵母シングルサブユニット・NADH-キノン酸化還元酵素(Ndi1)のキノン還元部位の解析2007
- Author(s)
  山下哲生、楊宇、小木曾(中丸)映子、三芳秀人、矢木(松野)明美、矢木隆雄、小坂博昭
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-19870016
[Presentation] 酵母シングルサブユニット・NADH-キノン酸化還元酵素(Ndi1)のキノン還元部位の解析2007
- Author(s)
  山下哲生、楊宇、小木曾(中丸)映子、三芳秀人、矢木(松野)明美、矢木隆雄、小坂博昭
- Organizer
  日本生体エネルギー研究会第33回討論会
- Place of Presentation
  山口
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-19870016
[Presentation] ミトコンドリアNADH脱水素酵素（NDH-2）においてThr239残基は活性酸素の生成を抑制する
- Author(s)
  山下　哲生
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590260
[Presentation] 酵母type II NADH脱水素酵素（Ndi1）の活性酸素の生成抑制機構の解析
- Author(s)
  山下　哲生
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590260
[Presentation] 大腸菌発現系を用いたApoptosis-inducing factor (AIF)と生体膜との相互作用の解析
- Author(s)
  山下哲生、橋本剛、五十嵐淳介、平野勝也、小阪博昭
- Organizer
  日本生体エネルギー研究会　第４０回討論会
- Place of Presentation
  愛媛大学　城北キャンパス
- Year and Date
  2014-12-11 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25840036

1. Kurahara Lin (00341438)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. IWAKI Masahiro (30140346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KOSAKA Hiroaki (60158897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. OHIRA Tetsuya (50448031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KITAMURA Akihiko (80450922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KITA Kiyoshi (90134444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. HARADA Shigeharu (80156504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. SHIBA Tomoo (80401206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. Inaoka Daniel K (10623803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 川瀬篤史 (80411578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 平石敬三 (60896413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 松田陽子 (20363187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 平野勝也 (80291516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 橋本剛 (80380153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMASHITA Tetsuo 山下 哲生

山下 哲生 ヤマシタ テツオ

Research Projects

Research Products

Co-Researchers

Elucidation and regulation of the senescence-accelerating function of coagulation system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New therapeutic strategy for inflammatory bowel disease and inflammatory carcinogenesis from breast milk-derived probiotics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the reaction mechanism of type II NADH dehydrogenase by structural and biochemical analyses of the enzyme-inhibitor interaction.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The structural insight into ROS suppression mechanism of type II NADH dehydrogenase (NDH-2)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of metabolic enzymes and transporters in diclofenac-induced liver injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction mechanism of AIF-related cell death

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of ubiquinone reduction mechanism of mitochondrial single-subunit NADH quinone oxidoreductasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Therapeutic Effect of Proteinase-Activated Receptor-1 Antagonist on Colitis-Associated Carcinogenesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lactulose modulates the structure of gut microbiota and alleviates colitis-associated tumorigenesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 腸炎関連発がんに対する希少糖D-アロースの治療効果2023

Author(s)

Organizer

Data Source

[Presentation] 炎症性大腸腫瘍モデルにおける希少糖D-アロースの腫瘍抑制効果2021

Author(s)

Organizer

Data Source

[Presentation] 競合および混合阻害剤との共結晶構造解析により明らかとなった出芽酵母由来Type II NADH脱水素酵素のユビキノン結合部位2018

Author(s)

Organizer

Data Source

[Presentation] 出芽酵母由来Type II NADH dehydrogenase (NDH-2)のユビキノン競合阻害剤との高分解能複合体構造解析2015

Author(s)

Organizer

Place of Presentation

Year and Date

YAMASHITA Tetsuo 山下哲生

山下哲生ヤマシタテツオ